Manman Zhang, Lei Li, Cheng Li, Aifang Ma, Junzhou Li, Chenyu Yang, Xujun Chen, Peng Cao, Shanshan Li, Yanyan Zhang, Zhiguang Yuchi, Xiangge Du, Chongxi Liu, Xiangjing Wang, Xiaodan Wang, Wensheng Xiang
Bacterial diseases caused substantial yield losses worldwide, with the rise of antibiotic resistance, there is a critical need for alternative antibacterial compounds. Natural products (NPs) from microorganisms have emerged as promising candidates due to their potential as cost-effective and environmentally friendly bactericides. However, the precise mechanisms underlying the antibacterial activity of many NPs, including Guvermectin (GV), remain poorly understood. Here, we sought to explore how GV interacts with Guanosine 5'-monophosphate synthetase (GMPs), an enzyme crucial in bacterial guanine synthesis...
April 10, 2024: International Journal of Biological Macromolecules