Xiangfeng Lai, Seong Hoong Chow, Anton P Le Brun, Benjamin W Muir, Phillip J Bergen, Jacinta White, Heidi H Yu, Jiping Wang, Jill Danne, Jhih-Hang Jiang, Francesca L Short, Mei-Ling Han, Richard A Strugnell, Jiangning Song, Neil R Cameron, Anton Y Peleg, Jian Li, Hsin-Hui Shen
The rapid increase and spread of Gram-negative bacteria resistant to many or all existing treatments threaten a return to the preantibiotic era. The presence of bacterial polysaccharides that impede the penetration of many antimicrobials and protect them from the innate immune system contributes to resistance and pathogenicity. No currently approved antibiotics target the polysaccharide regions of microbes. Here, describe monolaurin-based niosomes, the first lipid nanoparticles that can eliminate bacterial polysaccharides from hypervirulent Klebsiella pneumoniae, are described...
October 5, 2023: Small