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https://www.readbyqxmd.com/read/28227791/nonlinear-3-d-simulation-of-high-intensity-focused-ultrasound-therapy-in-the-kidney
#1
Visa Suomi, Jiri Jaros, Bradley Treeby, Robin Cleveland, Visa Suomi, Jiri Jaros, Bradley Treeby, Robin Cleveland, Jiri Jaros, Bradley Treeby, Robin Cleveland, Visa Suomi
Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat and kidney...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225795/multicenter-experiences-in-temporal-bone-cancer-surgery-based-on-89-cases
#2
Małgorzata Wierzbicka, Kazimierz Niemczyk, Antoni Bruzgielewicz, Marcin Durko, Janusz Klatka, Tomasz Kopeć, Ewa Osuch-Wójcikiewicz, Wioletta Pietruszewska, Marcin Szymański, Witold Szyfter
OBJECTIVE: To present outcomes of extensive surgery: lateral, subtotal, total petrosectomies in patients with temporal bone invasion resulting from specific primary cancers. STUDY DESIGN: Retrospective case review. SETTING: Four tertiary referral centers. MATERIAL: 89 patients with cancer of the temporal bone treated between January 2006 and December 2010. INTERVENTION: Multidisciplinary team approach including surgical resection, reconstruction, and postoperative radiotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28225319/cone-beam-computed-tomography-and-histological-evaluations-of-a-straight-electrode-array-positioning-in-temporal-bones
#3
Isabelle Mosnier, Charlotte Célérier, Jean-Loup Bensimon, Daniele de Seta, Olivier Sterkers, Yann Nguyen, Daniele Bernardeschi
CONCLUSION: CBCT allows a precise evaluation of the dimensions and of the shape of the cochlear duct that is of primary importance for the choice of the length and the design of the electrode array. This radio-histological study confirms that CBCT is a reliable tool to be used in clinical studies to evaluate the position of straight electrode arrays within the cochlear scala. OBJECTIVE: To validate the reliability of cone beam computed tomography (CBCT) in the evaluation of cochlear anatomy and positioning of a straight electrode array, by comparing radiological images to histological analysis of cochlear implanted temporal bones...
March 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28223015/surgical-management-of-ankyloses-of-the-temporomandibular-joint-by-a-piezoelectric-device
#4
Giuseppe Spinelli, Domenico Valente, Giuditta Mannelli, Mirco Raffaini, Francesco Arcuri
INTRODUCTION: Piezosurgery is commonly used in different field of craniomaxillofacial surgery; since its introduction it has become one of the widely adopted technique for performing osteotomies in orthognathic surgery, distraction osteogenesis and dentoalveolar surgery. Little has been written regarding ultrasonic system for temporomandibular joint surgery (TMJ). In this prospective study we describe the use of piezoelectric device for ankylosis of the TMJ. MATERIALS AND METHODS: We enrolled in this study 19 patients, 10 males and 9 females, mean (SD) age 24...
December 18, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28219414/severe-skull-base-osteomyelitis-caused-by-pseudomonas-aeruginosa-with-successful-outcome-after-prolonged-outpatient-therapy-with-continuous-infusion-of-ceftazidime-and-oral-ciprofloxacin-a-case-report
#5
Cristina Conde-Díaz, Jara Llenas-García, Mónica Parra Grande, Gertrudis Terol Esclapez, Mar Masiá, Félix Gutiérrez
BACKGROUND: Skull base osteomyelitis is an uncommon disease that usually complicates a malignant external otitis with temporal bone involvement. It affects predominantly diabetic and immunocompromised males and has a high mortality rate. Pseudomonas aeruginosa is the most common causative organism. Currently, there is no consensus about the best therapeutic option. Here we describe a case of severe skull base osteomyelitis caused by Pseudomonas aeruginosa with progressive palsy of cranial nerves that was successfully managed with prolonged outpatient continuous infusion of ceftazidime plus oral ciprofloxacin...
February 21, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28216817/turned-in-fasciocutaneous-island-flap-from-face-and-neck-based-on-subdermal-microcirculation-for-reconstruction-of-the-oral-cavity-following-cancer-surgery
#6
Kalpesh Jayantkumar Gajiwala
BACKGROUND: The skin and soft tissues of the face and neck have a rich plexus of dermal-subdermal vessels, which creates the possibility of raising a fasciocutaneous flap based on this vascular supply. A turned in fasciocutaneous island flap (TIFCIF) from an adjacent area of the defect can provide a simple substitute to many complex reconstructive procedures. MATERIALS AND METHODS: Fifteen patients underwent wide excision for oral cancer and upper neck dissection, maintaining bone framework, between August 2010 and June 2014...
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28216507/-a-case-report-for-giant-cholesteatoma-occurred-in-%C3%A2-fronto-parietal-bone
#7
Yu Zhou, Yugang Jiang
Cholesteatoma is a destructive and expanding growth benign tumor, mainly consisting of stratified squamous epithelium. It possesses the capacity of eroding bone and can exist in a nonaggressive state, remaining undetected for years. Once cholesteatoma appeared, it grows relentlessly and threats to invade intra-temporal structures. Most cholesteatomas occurred in the petrous bone and also affected the labyrinth and middle cranial fossa. Here, we report a preliminary wrongly-diagnosed case. The patient was wrongly diagnosed as "sebaceous cyst with infection" by local hospital...
January 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28216124/the-pattern-and-degree-of-capsular-fibrous-sheaths-surrounding-cochlear-electrode-arrays
#8
Reuven Ishai, Barbara S Herrmann, Joseph B Nadol, Alicia M Quesnel
An inflammatory tissue reaction around the electrode array of a cochlear implant (CI) is common, in particular at the electrode insertion region (cochleostomy) where mechanical trauma often occurs. However, the factors determining the amount and causes of fibrous reaction surrounding the stimulating electrode, especially medially near the perimodiolar location, are unclear. Temporal bone (TB) specimens from patients who had undergone cochlear implantation during life with either Advanced Bionics (AB) Clarion (TM) or HiRes90K(TM) (Sylmar, CA, USA) devices that have a half-band and a pre-curved electrode, or Cochlear (TM) Nucleus (Sydney, Australia) device that have a full-band and a straight electrode were evaluated...
February 16, 2017: Hearing Research
https://www.readbyqxmd.com/read/28215222/nf-%C3%AE%C2%BAb-as-a-therapeutic-target-in-inflammatory-associated-bone-diseases
#9
T-H Lin, J Pajarinen, L Lu, A Nabeshima, L A Cordova, Z Yao, S B Goodman
Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue homeostasis. In the skeletal system, inflammation is closely associated with many bone disorders including fractures, nonunions, periprosthetic osteolysis (bone loss around orthopedic implants), and osteoporosis. Acute inflammation is a critical step for proper bone-healing and bone-remodeling processes. On the other hand, chronic inflammation with excessive proinflammatory cytokines disrupts the balance of skeletal homeostasis involving osteoblastic (bone formation) and osteoclastic (bone resorption) activities...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28212886/primary-ameloblastoma-of-the-temporal-bone
#10
Andro Košec, Jakov Ajduk, Mihael Ries, Robert Trotić
Ameloblastoma is a locally aggressive tumor derived from odontogenic epithelium. Although benign, its clinical behavior can often exhibit malignant characteristics. It is marked by slow and persistent growth with infiltration of adjacent tissues. Almost 70% occur in the mandible in patients older than 30 years. Recurrence of ameloblastoma from inadequate treatment is frequent. Because of its slow growth, recurrences can present decades after primary surgery. A primary ameloblastoma in an area outside the mandibular, maxillary, and infratemporal fossa regions has not been described in detail to date, with only 1 possible case mentioned in the literature...
January 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28207625/a-three-dimensional-geometric-morphometric-study-to-quantify-temporal-bone-growth-and-its-consequences-for-the-success-of-implanting-bone-anchored-hearing-devices
#11
Sebastian Schilde, Stefan K Plontke, Torsten Rahne
OBJECTIVE: A computed tomography (CT)-based morphological-investigation to describe temporal bone growth and to devise a predictive test of the likely success of Bonebridge implantation into the growing mastoid region of the temporal bone in young patients. STUDY DESIGN: Retrospective cross-sectional study. SETTING: University Hospital Halle (Saale), Germany. PATIENTS: Two cohorts participated. This first, of patients aged less than 21 years, comprised 42 men, and 33 women patients...
February 15, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28207578/the-impact-of-a-cochlear-implant-electrode-array-on-the-middle-ear-transfer-function
#12
David Pazen, Andreas Anagiotos, Maike Nünning, Antoniu-Oreste Gostian, Magdalene Ortmann, Dirk Beutner
OBJECTIVES: As a treatment for partial deafness with residual hearing in the lower frequency range, the combined acoustic and electric stimulation of the cochlea has become widespread. Acoustic stimulation is provided by a hearing aid's airborne sound and the electric stimulation by a cochlear implant electrode array, which may be inserted through the round window or a cochleostomy. To take advantage of that concept, it is essential to preserve residual hearing after surgery. Therefore, the intracochlear electrode array should not compromise the middle ear vibration transmission...
February 15, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28195997/development-and-validation-of-the-cochlear-implant-surgical-competency-assessment-instrument
#13
Thomas Balkany, Kaming Lo, Howard Francis, Simon Angeli, Michael Novak, William Luxford, Rodney Lusk, Heather Strader
OBJECTIVE: We present a new instrument for evaluation of cochlear implant (CI) surgical skills and review its validation process. METHODS: An instrument to assess CI surgical competency incorporated results of structured surveys of comprehensiveness sent to 30 international CI experts and US trainees. One-hundred evaluations of 28 residents, fellows, and practicing CI surgeons were completed. Surgical skills were evaluated by four experienced neurotologists (two raters per subject) using two temporal bones per subject...
February 10, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28195746/thermal-variations-of-operative-microscopes-in-otology
#14
T Edward Imbery, Alex J Tampio, Brian D Nicholas
Objectives (1) Measure temperature variations achieved by common otomicroscopes. (2) Raise awareness about possible thermal injury during otologic procedures with the advent of newer, high-powered otomicroscopes. (3) Describe optical technology that aims to reduce the potential for thermal injury. Methods A variety of otomicroscopes, with different light sources (ranging from 100W halogen to 300W xenon), were studied. Temperatures were recorded from human auricular skin with a noncontact infrared thermometer at various microscope light intensities and with use of irrigation...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28194509/fetal-facial-nerve-course-in-the-ear-region-revisited
#15
Zhe Wu Jin, Kwang Ho Cho, Hiroshi Abe, Yukio Katori, Gen Murakami, Jose Francisco Rodríguez-Vázquez
PURPOSE: The aim of this study was to re-examine the structures that determine course of the facial nerve (FN) in the fetal ear region. MATERIALS AND METHODS: We used sagittal or horizontal sections of 28 human fetuses at 7-8, 12-16, and 25-37 weeks. RESULTS: The FN and the chorda tympani nerve ran almost parallel until 7 weeks. The greater petrosal nerve (GPN) ran vertical to the distal FN course due to the trigeminal nerve ganglion being medial to the geniculate ganglion at 7 weeks...
February 14, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28193299/otolaryngology-outreach-to-komfo-anokye-teaching-hospital-a-medical-and-educational-partnership
#16
B Waller, R Larsen-Reindorf, M Duah, J Opoku-Buabeng, B M Edwards, D Brown, J Moyer, M Prince, G J Basura
BACKGROUND: Medical and educational partnerships between high- and low-resourced countries provide opportunities to have a long-term meaningful impact on medical training and healthcare delivery. METHODS: An otolaryngology partnership between Komfo Anokye Teaching Hospital in Kumasi, Ghana, and the University of Michigan Department of Otolaryngology/Head and Neck Surgery has been undertaken to enhance healthcare delivery at both institutions. RESULTS: A temporal bone dissection laboratory, with the equipment to perform dedicated otological surgery, and academic platforms for clinical and medical education and residency training have been established...
February 14, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28192381/plasmacytoma-of-the-temporal-bone-a-great-imitator-report-of-seven-cases-and-comprehensive-review-of-the-literature
#17
Alex D Sweeney, Jacob B Hunter, S Vincent Rajkumar, John I Lane, Dragan Jevremovic, Matthew L Carlson
OBJECTIVES: To describe the clinical presentation, radiological features, and outcome of patients with plasmacytoma of the temporal bone. METHODS: Multicenter retrospective case series of all patients diagnosed with plasmacytoma of the temporal bone between 1990 and 2015. Comprehensive literature review of all previously published cases. RESULTS: A total of seven patients (average age, 57.3 yr; 57% women) met inclusion criteria. Three (43%) had a known history of multiple myeloma (MM)...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28191763/electrical-cell-substrate-impedance-spectroscopy-can-monitor-age-grouped-human-adipose-stem-cell-variability-during-osteogenic-differentiation
#18
Rachel C Nordberg, Jianlei Zhang, Emily H Griffith, Matthew W Frank, Binil Starly, Elizabeth G Loboa
Human adipose stem cells (hASCs) are an attractive cell source for bone tissue engineering applications. However, a critical issue to be addressed before widespread hASC clinical translation is the dramatic variability in proliferative capacity and osteogenic potential among hASCs isolated from different donors. The goal of this study was to test our hypothesis that electrical cell-substrate impedance spectroscopy (ECIS) could track complex bioimpedance patterns of hASCs throughout proliferation and osteogenic differentiation to better understand and predict variability among hASC populations...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28188849/endocytosis-contributes-to-bmp2-induced-smad-signalling-and-neuronal-growth
#19
Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeffe
Bone morphogenetic protein 2 (BMP2) is a neurotrophic factor which induces the growth of midbrain dopaminergic (DA) neurons in vitro and in vivo, and its neurotrophic effects have been shown to be dependent on activation of BMP receptors (BMPRs) and Smad 1/5/8 signalling. However, the precise intracellular cascades that regulate BMP2-BMPR-Smad-signalling-induced neurite growth remain unknown. Endocytosis has been shown to regulate Smad 1/5/8 signalling and differentiation induced by BMPs. However, these studies were carried out in non-neural cells...
February 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28182776/prospects-and-limitations-of-improving-skeletal-growth-in-a-mouse-model-of-spondyloepiphyseal-dysplasia-caused-by-r992c-p-r1192c-substitution-in-collagen-ii
#20
Machiko Arita, Jolanta Fertala, Cheryl Hou, James Kostas, Andrzej Steplewski, Andrzej Fertala
Skeletal dysplasias form a group of skeletal disorders caused by mutations in macromolecules of cartilage and bone. The severity of skeletal dysplasias ranges from precocious arthropathy to perinatal lethality. Although the pathomechanisms of these disorders are generally well defined, the feasibility of repairing established aberrant skeletal tissues that developed in the presence of mutant molecules is currently unknown. Here, we employed a validated mouse model of spondyloepiphyseal dysplasia (SED) that enables temporal control of the production of the R992C (p...
2017: PloS One
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