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https://www.readbyqxmd.com/read/28820756/telmesani-radiological-classification-of-the-location-of-the-vertical-segment-of-the-facial-nerve-impact-on-surgical-approach-in-cochlear-implant-surgery
#1
Laila Mohammed Telmesani, Mona Khalid Alrammah
OBJECTIVE: This study was conducted to establish a radiological classification of the location of the vertical segment of the facial nerve (VSFN) and to see if this has implications on the surgical technique needed to access the round window niche (RWN) in cochlear implant (CI) surgery. STUDY DESIGN: Observational case series study. SETTING: Tertiary referral center. PATIENTS: One hundred twenty seven patients underwent CI surgery, and high resolution computed tomography (HRCT) of 140 temporal bones was studied...
August 17, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28819787/flexible-semi-parametric-regression-of-state-occupational-probabilities-in-a-multistate-model-with-right-censored-data
#2
Chathura Siriwardhana, K B Kulasekera, Somnath Datta
Inference for the state occupation probabilities, given a set of baseline covariates, is an important problem in survival analysis and time to event multistate data. We introduce an inverse censoring probability re-weighted semi-parametric single index model based approach to estimate conditional state occupation probabilities of a given individual in a multistate model under right-censoring. Besides obtaining a temporal regression function, we also test the potential time varying effect of a baseline covariate on future state occupation...
August 17, 2017: Lifetime Data Analysis
https://www.readbyqxmd.com/read/28819617/the-antioxidant-effect-of-curcumin-on-cochlear-fibroblasts-in-rat-models-of-diabetes-mellitus
#3
Tengku-Siti-Hajar Haryuna, Delfitri Munir, Ana Maria, Jenny Bashiruddin
INTRODUCTION: The aim of this study was to investigate the potential of curcumin as an antioxidant to increase the expression of superoxide dismutase (SOD) in fibroblasts of the cochlear lateral wall in rat models of diabetes mellitus. MATERIALS AND METHODS: Twenty-four male Wistar rats Rattus norvegicus were randomly divided into six groups: group 1 as the control group; group 2 as the diabetic group; group 3 and 4 as the diabetic groups that received curcumin therapy of 200 and 400 mg/kg b...
July 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28816695/audiological-and-radiological-characteristics-in-incomplete-partition-malformations
#4
Merve Özbal Batuk, Betül Çiçek Çınar, Burçe Özgen, Gonca Sennaroğlu, Levent Sennaroğlu
OBJECTIVE: To compare the audiological and radiological findings of patients with incomplete partition malformations (IPs) and analyze the relationship between the audiological and radiological findings. MATERIALS AND METHODS: The study included 84 patients (168 ears) with IPs as follows: 26 patients with Type I;IP-I (41 ears), 54 patients with Type II;IP-II (108 ears), and 4 patients with Type III;IP-III (8 ears). Remaining 11 ears were diagnosed with other inner ear malformations...
August 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28803051/variations-in-the-labyrinthine-segment-of-facial-nerve-canal-revealed-by-high-resolution-computed-tomography
#5
Aiyan Jin, Peng Xu, Fengqin Qu
OBJECTIVE: To study variations in the labyrinthine segment of fallopian canal and the associated middle and inner ear malformations. METHOD: The high-resolution computed tomography (HRCT) images of the temporal bone in 24 patients with congenital variations in the labyrinthine segment of fallopian canal were analyzed retrospectively. The length of labyrinthine segment of the facial nerve and angle of the first genu of 10 normal subjects were also measured. Based on the original axial images, multi-planar reformation (MPR) and curved-planar reformation (CPR) images of bilateral ossicular chains, inner ear structure and fallopian canal were reconstructed...
August 9, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28802389/cholesteatoma-as-a-complication-of-langerhans-cell-histiocytosis-of-the-temporal-bone-a-nationwide-cross-sectional-analysis
#6
Jonathan C Simmonds, Mark Vecchiotti
OBJECTIVE: To determine if patients with Langerhans Cell Histiocytosis (LCH) of the temporal bone have a higher risk of developing cholesteatoma. METHODS: Review of literature and cross-sectional weighted analysis of patients under 19 with a diagnosis of LCH from the National Inpatient Sample (NIS) and Kids' Inpatient Database (KID) from 2000 to 2013. ICD-9 codes and demographics were analyzed; pairwise comparisons and multivariate analyses were performed. RESULTS: Only seven cases of cholesteatoma after the treatment for LCH of the temporal bone have been documented in the literature...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28799867/endoscope-assisted-repair-of-csf-otorrhea-and-temporal-lobe-encephaloceles-via-keyhole-craniotomy
#7
Pamela C Roehm, Derrick Tint, Norman Chan, Ryan Brewster, Vishad Sukul, Kadir Erkmen
OBJECTIVE Temporal lobe encephaloceles and cerebrospinal fluid otorrhea from temporal bone defects that involve the tegmen tympani and mastoideum are generally repaired using middle fossa craniotomy, mastoidectomy, or combined approaches. Standard middle fossa craniotomy exposes patients to dural retraction, which can lead to postoperative neurological complications. Endoscopic and minimally invasive techniques have been used in other surgeries to minimize brain retraction, and so these methods were applied to repair the lateral skull base...
August 11, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28799451/radiological-clinical-and-audiological-evaluation-of-jugular-bulb-vestibular-aqueduct-dehiscence
#8
Asli Tanrivermis Sayit, Muzaffer Elmali, Ozgur Kemal, Yuksel Terzi
OBJECTIVE: The aim of this study is to determine the prevalence of jugular bulb-vestibular aqueduct dehiscence (JBVAD) in patients undergoing temporal bone multidetector computed tomography (MDCT) and assess the relationship between JBVAD and hearing loss with the findings of audiometry. METHODS: About 1503 temporal bone MDCT scans were evaluated for the prevalence of JBVAD. Correlation of the imaging findings and audiometric data was performed. Patients were divided into two groups, those with and those without hearing loss, and were statistically compared...
August 11, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28796849/neutrophil-extracellular-traps-and-fibrin-in-otitis-media-analysis-of-human-and-chinchilla-temporal-bones
#9
Patricia A Schachern, Geeyoun Kwon, David E Briles, Patricia Ferrieri, Steven Juhn, Sebahattin Cureoglu, Michael M Paparella, Vladimir Tsuprun
Background: Bacterial resistance in acute otitis can result in bacterial persistence and biofilm formation, triggering chronic and recurrent infections. Objective: To investigate the middle ear inflammatory response to bacterial infection in human and chinchilla temporal bones. Design, Setting, and Participants: Six chinchillas underwent intrabullar inoculations with 0.5 mL of 106 colony-forming units (CFUs) of Streptococcus pneumoniae, serotype 2...
August 10, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28796089/anatomical-relationship-of-the-middle-cranial-fossa-dura-to-surface-landmarks-of-the-temporal-bone
#10
Mohamed A Alhussaini, Jameson K Mattingly, Stephen P Cass
HYPOTHESIS: The suprameatal crest and temporal line provides a reliable landmark to the middle fossa dura. BACKGROUND: Surface anatomy of the temporal bone is used to guide mastoid surgery, but studies investigating these landmarks are limited. The aim of this study was to examine the anatomical relationship of the middle fossa dura to the temporal line. METHODS: Thirty-two fresh hemicephalic temporal bones were prepared by drawing four lines along the mastoid including the suprameatal crest and temporal line (line 2), one line 5 mm superior to line 2 (line 1), and one 5 mm inferior to line 2 (line 3), and at Reid's base line (line 4)...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28796084/surgery-with-or-without-postoperative-radiation-therapy-for-early-stage-external-auditory-canal-squamous-cell-carcinoma-a-meta-analysis
#11
Ryohei Oya, Yukinori Takenaka, Kazuya Takemura, Naoki Ashida, Kotaro Shimizu, Takahiro Kitamura, Yoshifumi Yamamoto, Atsuhiko Uno
OBJECTIVE: External auditory canal squamous cell carcinoma (EACSCC) is a rare disease with no standard treatment supported by high-level evidence. The aim of this study was to investigate EACSCC prognoses according to treatment modality and thus determine the optimal intervention for early-stage disease. DATA SOURCES: PubMed, Scopus, and Ichushi-Web searches of the English and Japanese-language literature published between January 1, 2006 and December 31, 2016 were performed using the key words "external auditory canal cancer" and "temporal bone cancer...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28796083/a-new-slim-modiolar-electrode-array-for-cochlear-implantation-a-radiological-and-histological-study
#12
Matti Iso-Mustajärvi, Hanna Matikka, Frank Risi, Sini Sipari, Teemu Koski, Tytti Willberg, Antti Lehtimäki, Jyrki Tervaniemi, Heikki Löppönen, Aarno Dietz
HYPOTHESIS: To explore the results of a new slim modiolar electrode array (SMA) with respect to intracochlear placement and trauma evaluated by detailed radiologic imaging and histology. BACKGROUND: Hearing and structure preservation is the goal of cochlear implantation for advanced hearing outcomes. Currently, this is most consistently achieved with thin lateral wall electrodes. Modiolar electrodes are located nearer the modiolus and may provide some electrophysiological advantages, but have a greater tendency for causing insertion trauma...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28796082/the-first-reported-case-of-primary-intestinal-type-adenocarcinoma-of-the-middle-ear-and-review-of-the-literature
#13
Marc-Elie Nader, Diana Bell, Lawrence Ginsberg, Franco DeMonte, G Brandon Gunn, Paul W Gidley
OBJECTIVE: Adenocarcinoma of the middle ear is a rare entity that must be distinguished from other adenomatous tumors of the temporal bone. We present the first patient of an intestinal-type adenocarcinoma originating from the middle ear. PATIENTS: A 58-year-old woman presented with an 8-year history of left otorrhea. Her middle ear effusions were quite thick and gummy. She underwent eight sets of pressure-equalization tubes within 3 years. In 2011, her physical examination identified a middle ear mass, and she underwent mastoidectomy...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28789969/tissue-control-of-androgen-action-the-ups-and-downs-of-androgen-receptor-expression
#14
REVIEW
Irene Hunter, Colin W Hay, Bianca Esswein, Kate Watt, Iain J McEwan
The hormone testosterone plays crucial roles during male development and puberty and throughout life, as an anabolic regulator of muscle and bone structure and function. The actions of testosterone are mediated, primarily, through the androgen receptor, a member of the nuclear receptor superfamily. The androgen receptor gene is located on the X-chromosome and receptor levels are tightly controlled both at the level of transcription of the gene and post-translationally at the protein level. Sp1 has emerged as the major driver of expression of the androgen receptor gene, while auto-regulation by androgens is associated with both positive and negative regulation in a possible cell-selective manner...
August 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28782544/congenital-amusics-use-a-secondary-pitch-mechanism-to-identify-lexical-tones
#15
Oliver Bones, Patrick C M Wong
Amusia is a pitch perception disorder associated with deficits in processing and production of both musical and lexical tones, which previous reports have suggested may be constrained to fine-grained pitch judgements. In the present study speakers of tone-languages, in which lexical tones are used to convey meaning, identified words present in chimera stimuli containing conflicting pitch-cues in the temporal fine-structure and temporal envelope, and which therefore conveyed two distinct utterances. Amusics were found to be more likely than controls to judge the word according to the envelope pitch-cues...
August 4, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28777742/dramatic-response-of-ctnnb1-and-vegfr-2-mutant-temporal-bone-squamous-cell-carcinoma-to-bevacizumab-in-combination-with-pemetrexed
#16
Lai Wei, Lizhi Wang, Ziye Liu, Meiyi Wang, Weili Lu, Dewei Zhao, Bin Yang, Xuejun Kong, Yan Ding, Zhiqiang Wang
High recurrence rates and poor survival rates for late stage/advanced temporal bone squamous cell carcinoma with the standard treatments continues to be a significant challenge to otolaryngologists. Targeted therapy for temporal bone squamous cell carcinoma after relapse has not been reported. Here we present a 58-year-old man who was diagnosed with recurrent temporal bone squamous cell carcinoma and treated with a regimen developed using whole exome sequencing. Somatic mutations in genes encoding catenin beta 1 and vascular endothelial growth factor receptor 2 were identified in the patient's tumor sample compared to the normal tissue...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28777229/the-modified-rambo-transcanal-approach-for-cochlear-implantation-in-charge-syndrome
#17
Cameron C Wick, Amy M Moore, Daniel E Killeen, Brandon Isaacson
OBJECTIVE: CHARGE syndrome is associated with a variety of temporal bone anomalies and deafness. The lack of surgical landmarks and facial nerve irregularities make cochlear implantation in this population a challenging endeavor. This study aims to describe a safe and efficacious transcanal approach for cochlear implantation that obviates the need to perform a mastoidectomy and facial recess. PATIENTS: Three children with profound hearing loss secondary to CHARGE syndrome...
August 2, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28774486/histopathology-of-tympanic-membranes-from-patients-with-ventilation-tubes
#18
Mehmet Faruk Oktay, Hasan Deniz Tansuker, Hisaki Fukushima, Michael M Paparella, Patricia A Schachern, Sebahattin Cureoglu
OBJECTIVE: To evaluate the histopathologic changes in tympanic membranes (TMs) with ventilation tubes (VTs). METHODS: In this retrospective human temporal bone study our overall study group included 4 subgroups of TMs from deceased donors as follows: 24 with a history of VT insertion for chronic otitis media with effusion (COME-VT); 5 with a history of VT insertion for Meniere's disease (MD-VT); 33 without a history of VT insertion for chronic otitis media with effusion (COME); and 14 without a history of VT insertion for Meniere's disease (MD)...
July 31, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28764209/mastoid-osteoma-of-temporal-bone-a-rare-case-report
#19
Rahul Kumar Singh, Amit Goyal, Amit Kumar, Gaurav Kataria, Amber Kesarwani
Osteomas of the temporal bone are rare entity with incidence of 0.1% - 1% of all benign tumours of skull. They are slow growing benign lesion of temporal bone. We report a rare case of mastoid osteoma of size more than 5 cm. A 40-year-old female patient presented to us with left post auricular bony swelling of size greater than 5 cm. Diagnosis of mastoid osteoma was made after relevant investigations including High Resolution Computed Tomography (HRCT) temporal bone. Complete surgical excision was done with good cosmetic outcome without recurrence...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28753225/review-of-dynamic-contrast-enhanced-mri-technical-aspects-and-applications-in-the-musculoskeletal-system
#20
REVIEW
Parvinder Sujlana, Jan Skrok, Laura M Fayad
Although postcontrast imaging has been used for many years in musculoskeletal imaging, dynamic contrast enhanced (DCE) MRI is not routinely used in many centers around the world. Unlike conventional contrast-enhanced sequences, DCE-MRI allows the evaluation of the temporal pattern of enhancement in the musculoskeletal system, perhaps best known for its use in oncologic applications (such as differentiating benign from malignant tumors, evaluating for treatment response after neoadjuvant chemotherapy, and differentiating postsurgical changes from residual tumor)...
July 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
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