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Oncogene

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https://www.readbyqxmd.com/read/29909564/organized-screening-detects-breast-cancer-at-earlier-stage-regardless-of-molecular-phenotype
#1
Claire M B Holloway, Li Jiang, Marlo Whitehead, Jennifer M Racz, Patti A Groome
PURPOSE: Mortality reduction attributable to organized breast screening is modest. Screening may be less effective at detecting more aggressive cancers at an earlier stage. This study was conducted to determine the relative efficacy of screening mammography to detect cancers at an earlier stage by molecular phenotype. METHODS: We identified 2882 women with primary invasive breast cancer diagnosed between January 1, 2008 and December 31, 2012 and who had a mammogram through the Ontario Breast Screening Program in the 28 months before diagnosis...
June 16, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29909347/lncrna-xist-accelerates-cervical-cancer-progression-via-upregulating-fus-through-competitively-binding-with-mir-200a
#2
Hong Zhu, Tao Zheng, Jun Yu, Lixia Zhou, Lei Wang
As one of the commonest gynecological malignancies in the world, cervical cancer brings great threat for public health. Long non-coding RNAs (LncRNAs) have been proved to be closely related to the progression of various cancers, including cervical cancer. As a tumor promoter, lncRNA XIST has been reported in various malignant tumors. In this study, we aim to explore the specific mechanism and biological function of XIST in cervical cancer. At first, the expression levels of XIST were examined in both tissues and cell lines with qRT-PCR...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29908344/nitroxide-radical-containing-nanoparticles-attenuate-tumorigenic-potential-of-triple-negative-breast-cancer
#3
Babita Shashni, Yukio Nagasaki
The critical importance of reactive oxygen species (ROS) as oncogene activators and essential secondary messengers in cancer cell survival have been widely reported. Since oxidative stress has been implicated as being pivotal in various cancers, antioxidant therapy seems an apt strategy to abrogate ROS-mediated cellular processes to attenuate cancers. We therefore synthesized ROS scavenging nitroxide radical-containing nanoparticles (RNPs); pH insensitive RNPO and pH sensitive RNPN , to impede the proliferative and metastatic characteristics of the triple negative breast cancer cell line, MDA-MB-231, both in vitro and in vivo...
May 26, 2018: Biomaterials
https://www.readbyqxmd.com/read/29908282/the-function-and-clinical-significance-of-eif3-in-cancer
#4
REVIEW
Yuting Yin, Jiali Long, Yanqin Sun, Hongmei Li, Enping Jiang, Chao Zeng, Wei Zhu
Abnormal regulation of gene expression is essential for tumorigenesis. Several studies indicate that regulation of oncogene expression and neoplastic transformation are controlled by subunits of eukaryotic translation initiation factors (eIFs). Eukaryotic translation initiation factor 3 (eIF3) is the largest (800 kDa) and the most complex mammalian initiation factor. It is composed of 13 non-identical polypeptides designated as eIF3a-m and plays a pivotal role in protein synthesis that bridges the 43S pre-initiation complex and eIF4F-bound mRNA...
June 13, 2018: Gene
https://www.readbyqxmd.com/read/29908229/mir-1297-suppresses-pancreatic-cancer-cell-proliferation-and-metastasis-by-targeting-mtdh
#5
Zili Chen, Yifei Ma, Yaozhen Pan, Haitao Zhu, Chao Yu, Chengyi Sun
Dysregulation of miR-1297 has been detected in various human cancers, and miR-1297 can function as either an oncogene or tumor suppressor. However, the role of miR-1297 in pancreatic adenocarcinoma has not been previously reported. Here, we investigated miR-1297 expression in pancreatic cancer and the role it plays in the development and metastasis of pancreatic adenocarcinoma. In the present study, MiR-1297 and metadherin (MTDH) expression in pancreatic cancer tissue was detected using quantitative real-time PCR (qRT-PCR) and western blot methods...
June 13, 2018: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/29908100/exosomes-in-cancer-development-and-clinical-applications
#6
REVIEW
Yu-Ling Tai, Ko-Chien Chen, Jer-Tsong Hsieh, Tang-Long Shen
Exosomes participate in cancer progression and metastasis by transferring bioactive molecules between cancer and varied cells in the local and distant microenvironments. Such intercellular cross-talks result in changes in multiple cellular and biological functions in recipient cells. Several hallmarks of cancer have been reportedly impacted by this exosome-mediated cell-to-cell communication, including modulating immune responses, re-programming stromal cells, re-modeling the architecture of extracellular matrix, or even endowing cancer cells with characteristics of drug resistance...
June 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29907857/alterations-of-mtor-signaling-impact-metabolic-stress-resistance-in-colorectal-carcinomas-with-braf-and-kras-mutations
#7
Raphaela Fritsche-Guenther, Christin Zasada, Guido Mastrobuoni, Nadine Royla, Roman Rainer, Florian Roßner, Matthias Pietzke, Edda Klipp, Christine Sers, Stefan Kempa
Metabolic reprogramming is as a hallmark of cancer, and several studies have reported that BRAF and KRAS tumors may be accompanied by a deregulation of cellular metabolism. We investigated how BRAFV600E and KRASG12V affect cell metabolism, stress resistance and signaling in colorectal carcinoma cells driven by these mutations. KRASG12V expressing cells are characterized by the induction of glycolysis, accumulation of lactic acid and sensitivity to glycolytic inhibition. Notably mathematical modelling confirmed the critical role of MCT1 designating the survival of KRASG12V cells...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907771/mir-30-disrupts-senescence-and-promotes-cancer-by-targeting-both-p16-ink4a-and-dna-damage-pathways
#8
Weijun Su, Lixin Hong, Xin Xu, Shan Huang, Denise Herpai, Lisheng Li, Yingxi Xu, Lan Truong, Wen-Yuan Hu, Xiaohua Wu, Changchun Xiao, Wei Zhang, Jiahuai Han, Waldemar Debinski, Rong Xiang, Peiqing Sun
miR-30 is a microRNA frequently overexpressed in human cancers. However, the biological consequence of miR-30 overexpression in cancer has been unclear. In a genetic screen, miR-30 was found to abrogate oncogenic-induced senescence, a key tumor-suppressing mechanism that involves DNA damage responses, activation of p53 and induction of p16INK4A . In cells and mouse models, miR-30 disrupts senescence and promotes cancer by suppressing 2 targets, CHD7 and TNRC6A. We show that while CHD7 is a transcriptional coactivator essential for induction of p16INK4A in senescent cells, TNRC6A, a miRNA machinery component, is required for expression and functionality of DNA damage response RNAs (DDRNAs) that mediate DNA damage responses and p53 activation by orchestrating histone modifications, chromatin remodeling and recruitment of DNA damage factors at damaged sites...
June 15, 2018: Oncogene
https://www.readbyqxmd.com/read/29907679/the-tumour-suppressor-opcml-promotes-axl-inactivation-by-the-phosphatase-ptprg-in-ovarian-cancer
#9
Jane Antony, Elisa Zanini, Zoe Kelly, Tuan Zea Tan, Evdoxia Karali, Mohammad Alomary, Youngrock Jung, Katherine Nixon, Paula Cunnea, Christina Fotopoulou, Andrew Paterson, Sushmita Roy-Nawathe, Gordon B Mills, Ruby Yun-Ju Huang, Jean Paul Thiery, Hani Gabra, Chiara Recchi
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL directly interacts with OPCML, preferentially so when AXL is activated by its ligand Gas6. As a consequence, AXL accumulates in cholesterol-rich lipid domains, where OPCML resides. Here, phospho-AXL is brought in proximity to the lipid domain-restricted phosphatase PTPRG, which de-phosphorylates the RTK/ligand complex...
June 15, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29907296/surface-enhanced-raman-spectroscopy-based-immunosensor-for-ultrasensitive-and-selective-detection-of-wild-type-p53-and-mutant-p53-r175h
#10
Anna Rita Bizzarri, Ilaria Moscetti, Salvatore Cannistraro
p53 is a powerful transcription factor playing a pivotal role in the prevention of cancer development and in maintaining genome integrity. This oncosuppressor is found to be functionally inactivated by mutations in many human tumors. Accordingly, wild type p53 and its oncogenic mutants represent valuable cancer biomarkers for diagnostic and prognostic purposes. We developed a highly sensitive biosensor, based on Surface Enhanced Raman Spectroscopy, for detection of wild type p53 and of p53R175H , which is one of the most frequent tumor-associated mutants of p53...
October 31, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29907133/emerging-role-of-lipid-metabolism-alterations-in-cancer-stem-cells
#11
REVIEW
Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li, Bo Xiang
BACKGROUND: Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrence in cancer patients. Stem cells have distinct metabolic properties compared to differentiated cells, and metabolic rewiring contributes to self-renewal and stemness maintenance in CSCs. MAIN BODY: Recent advances in metabolomic detection, particularly in hyperspectral-stimulated raman scattering microscopy, have expanded our knowledge of the contribution of lipid metabolism to the generation and maintenance of CSCs...
June 15, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29906746/linc-pou3f3-is-overexpressed-in-hepatocellular-carcinoma-and-regulates-cell-proliferation-migration-and-invasion
#12
Yichun Li, Yannan Li, Dan Wang, Qingdong Meng
Linc-POU3F3 showed an up-regulated tendency and functioned as tumor promoter in glioma, esophageal cancer and colorectal cancer. There was no report about the expression pattern and clinical value of linc-POU3F3 in hepatocellular carcinoma. Thus, the purpose of our study is to explore the clinical significance and biological role of linc-POU3F3 in hepatocellular carcinoma. Our results suggested that levels of linc-POU3F3 were dramatically increased in hepatocellular carcinoma tissues and cell lines compared with paired normal hepatic tissues and normal hepatic cell line, respectively...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906745/long-noncoding-rna-linc00460-targets-mir-539-mmp-9-to-promote-meningioma-progression-and-metastasis
#13
Hongshun Xing, Shilei Wang, Quancai Li, Yongqian Ma, Peng Sun
Emerging evidence reveal that long noncoding RNAs (lncRNAs) participates in the epigenetic regulation of pathophysiological process. However, the deepgoing role of lncRNAs on meningioma is still unclear. In present study, we investigate the roles of lncRNA LINC00460 in meningeoma tissue and uncover its molecular mechanism. Results revealed that LINC00460 expression level was significantly up-regulated in meningeoma tissues and malignant meningeoma cell lines (IOMM-Lee, CH157-MN). Mechanically, loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906744/microrna-302c-represses-epithelial-mesenchymal-transition-and-metastasis-by-targeting-transcription-factor-ap-4-in-colorectal-cancer
#14
Wenqi Ma, Bailing Liu, Jie Li, Jue Jiang, Ru Zhou, Lili Huang, Xiaopeng Li, Xin He, Qi Zhou
MicroRNAs (miRNAs) contribute to tumorigenesis and progression via acting as tumor suppressors or oncogenes in human cancer. Aberrant expression of miR-302c has been reported in various types of cancer except colorectal cancer (CRC). Thus, our study was aimed to verify the expression of miR-302c and its functional role in CRC. We found a significant reduced expression of miR-302c in CRC tissues compared to tumor-adjacent tissues. Low miR-302c level was remarkably correlated with deeper tumor invasion, lymph node metastasis and advanced TNM stage...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906488/nrf2-activated-expression-of-sulfiredoxin-contributes-to-urethane-induced-lung-tumorigenesis
#15
Murli Mishra, Hong Jiang, Hedy A Chawsheen, Matthieu Gerard, Michel B Toledano, Qiou Wei
Lung cancer is the leading cause of cancer death worldwide. Cigarette smoking and exposure to chemical carcinogens are among the risk factors of lung tumorigenesis. In this study, we found that cigarette smoke condensate and urethane significantly stimulated the expression of sulfiredoxin (Srx) at the transcript and protein levels in cultured normal lung epithelial cells, and such stimulation was mediated through the activation of nuclear related factor 2 (Nrf2). To study the role of Srx in lung cancer development in vivo, mice with Srx wildtype, heterozygous or knockout genotype were subjected to the same protocol of urethane treatment to induce lung tumors...
June 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29906244/de-novo-lipogenesis-represents-a-therapeutic-target-in-mutant-kras-non-small-cell-lung-cancer
#16
Anju Singh, Christian Ruiz, Kavita Bhalla, John A Haley, Qing Kay Li, George Acquaah-Mensah, Emily Montal, Kuladeep R Sudini, Ferdinandos Skoulidis, Ignacio I Wistuba, Vassiliki Papadimitrakopoulou, John V Heymach, Laszlo G Boros, Edward Gabrielson, Julian Carretero, Kwok-Kin Wong, John D Haley, Shyam Biswal, Geoffrey D Girnun
Oncogenic Kras mutations are one of the most common alterations in non-small cell lung cancer and are associated with poor response to treatment and reduced survival. Driver oncogenes, such as Kras are now appreciated for their ability to promote tumor growth via up-regulation of anabolic pathways. Therefore, we wanted to identify metabolic vulnerabilities in Kras-mutant lung cancer. Using the Kras LSL-G12D lung cancer model, we show that mutant Kras drives a lipogenic gene-expression program. Stable-isotope analysis reveals that mutant Kras promotes de novo fatty acid synthesis in vitro and in vivo...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29905828/mir-149-negative-regulation-of-mafa-is-involved-in-the-arsenite-induced-dysfunction-of-insulin-synthesis-and-secretion-in-pancreatic-beta-cells
#17
Qian Sun, Qianlei Yang, Hui Xu, Junchao Xue, Chao Chen, Xingfen Yang, Xiaohua Gao, Qizhan Liu
Chronic exposure to arsenic, a potent environmental oxidative stressor, is associated with the incidence of diabetes. However, the mechanisms for arsenite-induced reduction of insulin remain largely unclear. After CD1 mice were treated with 20 or 40 ppm arsenite in the drinking water for 12 months, the mice showed reduced fasting insulin levels, a depression in glucose clearance, and lower insulin content in the pancreas. The levels of glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells isolated from arsenite-exposed mice were low compared to those for control mice...
June 14, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29904947/the-nogo-b-receptor-promotes-human-hepatocellular-carcinoma-cell-growth-via-the-akt-signal-pathway
#18
Chengyong Dong, Ying Liu, Keqiu Jiang, Haibo Wang, Weikun Qu, Chi Zhang, Rui Liang, Zhenming Gao, Baofeng Zhao, Qing Miao, Shujuan Shao, Liming Wang
Nogo-B receptor (NgBR) is a type I receptor with a single transmembrane domain and specifically binds to ligand Nogo-B. A previous study demonstrated that NgBR was highly expressed in human breast invasive ductal carcinoma and promoted epithelial-mesenchymal transition in breast tumor cells. Our recent work found that NgBR expression was associated with a poor prognosis in human patients with hepatocellular carcinoma (HCC). Here, we elucidate that the increased expression of NgBR contributes toward the increased cell growth of human HCC cells both in vitro and in vivo...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904939/the-lncrna-tp73-as1-promotes-ovarian-cancer-cell-proliferation-and-metastasis-via-modulation-of-mmp2-and-mmp9
#19
Xiaoqian Wang, Bing Yang, Yuanping She, Yuan Ye
Ovarian cancer is one of the most common gynecologic malignancy with poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators in cancer development. The current study investigated the role of lncRNA P73 antisense RNA 1T (TP73-AS1) in ovarian cancer. Quantitative real-time polymerase chain reaction determined the expression levels of TP-73AS1, matrix metallopeptidases (MMPs) messenger RNA. Cell proliferative ability, cell invasion, and migration were CCK-8 and colony formation, and transwell invasion and migration assays, respectively...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904919/linc00968-functions-as-an-oncogene-in-osteosarcoma-by-activating-the-pi3k-akt-mtor-signaling
#20
Gang Liu, Dongtang Yuan, Peng Sun, Weidong Liu, Peng-Fei Wu, Huan Liu, Guang-Yang Yu
Osteosarcoma is recognized as a malignant tumor in the skeletal system. Long non-coding RNAs (lncRNAs) have been exhibited to play crucial roles in osteosarcoma development. Our current study focused on the biological effects and mechanism of LINC00968 in osteosarcoma pathogenesis. We observed that LINC00968 was dramatically elevated in osteosarcoma cells including U2OS, MG63, Saos-2, SW1353, and 143-B cells compared to human osteoblast cell line hFOB. Silence of LINC00968 inhibited osteosarcoma cell growth and proliferation in vitro...
June 15, 2018: Journal of Cellular Physiology
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