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https://www.readbyqxmd.com/read/23844954/a-buprenorphine-education-and-training-program-for-primary-care-residents-implementation-and-evaluation
#1
Hillary V Kunins, Nancy L Sohler, Angela Giovanniello, Devin Thompson, Chinazo O Cunningham
BACKGROUND: Although substance use disorders are highly prevalent, resident preparation to care for patients with these disorders is frequently insufficient. With increasing rates of opioid abuse and dependence, and the availability of medication-assisted treatment, one strategy to improve resident skills is to incorporate buprenorphine treatment into training settings. METHODS: In this study, esidency faculty delivered the BupEd education and training program to 71 primary care residents...
2013: Substance Abuse
https://www.readbyqxmd.com/read/23755239/frequency-of-regulatory-t-cells-in-the-peripheral-blood-of-patients-with-pulmonary-tuberculosis-from-shanxi-province-china
#2
Hui Pang, Qin Yu, Buping Guo, Yi Jiang, Li Wan, Jun Li, Yanjun Wu, Kanglin Wan
BACKGROUND: Tuberculosis (TB) is a disease caused by the chronic and continuous infection of the pathogen Mycobacterium tuberculosis (M. tuberculosis). M. tuberculosis is an intracellular bacterial pathogen and is eliminated mainly through CD4(+) effector Th cells. M. tuberculosis induces regulatory T lymphocytes (Tregs) that mediate immune suppression by cell-to-cell contact or by secreting cytokines such as transforming growth factor-β (TGF-β). To understand the role of regulatory T-cells in the pathogenesis of TB, we have measured the in vivo frequency of regulatory T-cells and associated in vivo cytokine production in pulmonary tuberculosis patients...
2013: PloS One
https://www.readbyqxmd.com/read/21924375/edwardsiella-tarda-virulence-mechanisms-of-an-emerging-gastroenteritis-pathogen
#3
REVIEW
Ka Yin Leung, Bupe A Siame, Byron J Tenkink, Rebecca J Noort, Yu-Keung Mok
Human Edwardsiella tarda infections often manifest as gastroenteritis, but can become systemic and potentially lethal. E. tarda uses virulence factors that include type III and type VI secretion systems, quorum sensing, two-component systems, and exoenzymes to gain entry into and survive within the host. Better understanding of interactions between these factors will lead to the development of novel antimicrobials against E. tarda and other enterics.
January 2012: Microbes and Infection
https://www.readbyqxmd.com/read/20971679/type-vi-secretion-regulation-crosstalk-and-intracellular-communication
#4
REVIEW
Ka Yin Leung, Bupe A Siame, Heather Snowball, Yu-Keung Mok
Pathogens use type VI secretion systems (T6SSs) to transport proteins into the environment or host cells in response to external stimuli. T6SSs are tightly regulated together with other virulence determinants such as type III secretion systems, quorum sensing (QS), and flagella synthesis. Five pathogens (Salmonella enterica, Edwardsiella tarda, Aeromonas hydrophila, Vibrio cholerae, and Pseudomonas aeruginosa) are examined for crosstalk proteins (global regulators) that connect T6SSs to other virulence determinants...
February 2011: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/19838129/pregnancy-contraceptive-use-and-hiv-acquisition-in-hptn-039-relevance-for-hiv-prevention-trials-among-african-women
#5
Stewart E Reid, James Y Dai, Jing Wang, Bupe N Sichalwe, Godspower Akpomiemie, Frances M Cowan, Sinead Delany-Moretlwe, Jared M Baeten, James P Hughes, Anna Wald, Connie Celum
BACKGROUND: Biomedical HIV prevention trials enroll sexually active women at risk of HIV and often discontinue study product during pregnancy. We assessed risk factors for pregnancy and HIV acquisition, and the effect of pregnancy on time off study drug in HIV Prevention Trials Network 039. METHODS: A total of 1358 HIV negative, herpes simplex virus type 2-seropositive women from South Africa, Zambia, and Zimbabwe were enrolled and followed for up to 18 months. RESULTS: A total of 228 pregnancies occurred; time off study drug due to pregnancy accounted for 4% of woman-years of follow-up among women...
April 2010: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/19640849/hypoxia-up-regulates-cd36-expression-and-function-via-hypoxia-inducible-factor-1-and-phosphatidylinositol-3-kinase-dependent-mechanisms
#6
Bupe R Mwaikambo, Chun Yang, Sylvain Chemtob, Pierre Hardy
Neovascular and degenerative diseases of the eye are leading causes of impaired vision and blindness in the world. Hypoxia or reduced oxygen tension is considered central to the pathogenesis of these disorders. Although the CD36 scavenger receptor features prominently in ocular homeostasis and pathology, little is known regarding its modulation by hypoxia. Herein we investigated the role and regulation of CD36 by hypoxia and by the major hypoxia effector, hypoxia-inducible factor (HIF)-1. In vivo, hypoxia markedly induced CD36 mRNA in corneal and retinal tissue...
September 25, 2009: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/18978343/the-role-of-lysophosphatidic-acid-receptor-lpa1-in-the-oxygen-induced-retinal-ganglion-cell-degeneration
#7
Chun Yang, Josiane Lafleur, Bupe R Mwaikambo, Tang Zhu, Carmen Gagnon, Sylvain Chemtob, Adriana Di Polo, Pierre Hardy
PURPOSE: Although previous studies have demonstrated that hypoxia induces retinal ganglion cell (RGC) apoptosis and that transient retinal ischemia upregulates the expression of lysophosphatidic acid (LPA) receptors, it remains to be determined whether LPA(1) receptor mediates RGC degeneration during retinopathy of prematurity (ROP). By using an immortalized RGC line (RGC-5), primary neonatal RGC cultures, and oxygen-induced retinopathy (OIR) to model ROP, the authors explored whether LPA(1) receptor induces RGC degeneration and the potential mechanisms thereof...
March 2009: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/18812768/genetic-ablation-of-cd36-induces-age-related-corneal-neovascularization
#8
Bupe R Mwaikambo, Florian Sennlaub, Huy Ong, Sylvain Chemtob, Pierre Hardy
PURPOSE: Corneal avascularity is tightly regulated by a balance between angiogenic and antiangiogenic factors (angiogenic privilege). In the current study, we tested the hypothesis that the CD36+/+ antiangiogenic receptor contributes toward the maintenance of corneal avascularity. METHODS: Corneas of CD36 wild-type (CD36) and knockout (CD36) mice aged 4, 16, 52, and 78 weeks were histologically evaluated for corneal haze and neovascularization (NV). Quantitative real-time polymerase chain reaction was performed on corneal tissue from CD36+/+ and CD36-/- mice aged 4 and 52 weeks to examine the effect of CD36 deficiency on expression of relevant angiogenic factors...
October 2008: Cornea
https://www.readbyqxmd.com/read/18046016/lymphocytic-microparticles-inhibit-angiogenesis-by-stimulating-oxidative-stress-and-negatively-regulating-vegf-induced-pathways
#9
Chun Yang, Bupe R Mwaikambo, Tang Zhu, Carmen Gagnon, Josiane Lafleur, Swathi Seshadri, Pierre Lachapelle, Jean-Claude Lavoie, Sylvain Chemtob, Pierre Hardy
Recent studies have demonstrated that lymphocyte-derived microparticles (LMPs) impair endothelial cell function. However, no data currently exist regarding the contribution of LMPs in the regulation of angiogenesis. In the present study, we investigated the effects of LMPs on angiogenesis in vivo and in vitro and demonstrated that LMPs strongly suppressed aortic ring microvessel sprouting and in vivo corneal neovascularization. In vitro, LMPs considerably diminished human umbilical vein endothelial cell survival and proliferation in a concentration-dependent manner...
February 2008: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/17003426/activation-of-cd36-inhibits-and-induces-regression-of-inflammatory-corneal-neovascularization
#10
Bupe R Mwaikambo, Florian Sennlaub, Huy Ong, Sylvain Chemtob, Pierre Hardy
PURPOSE: This study was undertaken to investigate the role of the antiangiogenic receptor CD36 during inflammatory corneal neovascularization (CNV). METHODS: In a murine model of inflammatory CNV, CD36 expression was evaluated by RT-PCR and immunofluorescence. Mice subjected to CNV were treated topically (thrice daily) with CD36 functionally neutralizing antibodies against the oxidized low-density lipoprotein (oxLDL) and thrombospondin (TSP)-1 sites (clones JC63...
October 2006: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/16757036/evaluation-of-methods-for-the-isolation-detection-and-quantification-of-cyanobacterial-hepatotoxins
#11
REVIEW
Titus A M Msagati, Bupe A Siame, Deborah D Shushu
Cyanobacterial hepatotoxins such as microcystins and nodularins have been responsible for the poisoning of both animals and humans who ingest or come into contact with toxic blooms. They are extremely stable in water due to their stable chemical structure and can tolerate radical changes in water chemistry, including pH and salinity. Different methods for the extraction and detection of these compounds have been reported. Extraction methods utilizing both aqueous and organic solvent systems have been reported...
July 20, 2006: Aquatic Toxicology
https://www.readbyqxmd.com/read/16415498/inflammatory-lipid-mediators-in-ischemic-retinopathy
#12
REVIEW
Pierre Hardy, Martin Beauchamp, Florian Sennlaub, Fernand Jr Gobeil, Bupe Mwaikambo, Pierre Lachapelle, Sylvain Chemtob
Ischemic proliferative retinopathy develops in various retinal disorders, including retinal vein occlusion, diabetic retinopathy and retinopathy of prematurity. Ischemic retinopathy remains a common cause of visual impairment and blindness in the industrialized world due to relatively ineffective treatment. Oxygen-induced retinopathy (OIR) is an established model of retinopathy of prematurity associated with vascular cell injury culminating in microvascular degeneration, which precedes an abnormal neovascularization...
2005: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/16170615/fungi-aflatoxins-fumonisin-bl-and-zearalenone-contaminating-sorghum-based-traditional-malt-wort-and-beer-in-botswana
#13
David O Nkwe, Joanne E Taylor, Bupe A Siame
Brewing and consumption of traditional beer have social-economic significance in most African countries including Botswana. Traditional sorghum malt, wort, and beer samples were collected from three villages around Gaborone, Botswana. Forty-six malt samples were analyzed for fungi on three different media and developing colonies were subcultured for identification. Rhizopus, Fusarium, Mucor, and Aspergillus were the most common genera isolated. Out of the 46 malt samples, 72% contained Rhizopus stolonifer, 63% Fusarium verticillioides (syn...
September 2005: Mycopathologia
https://www.readbyqxmd.com/read/15850712/new-insights-into-the-retinal-circulation-inflammatory-lipid-mediators-in-ischemic-retinopathy
#14
REVIEW
Pierre Hardy, Martin Beauchamp, Florian Sennlaub, Fernand Gobeil, Lise Tremblay, Bupe Mwaikambo, Pierre Lachapelle, Sylvain Chemtob
Ischemic proliferative retinopathy develops in various retinal disorders, including retinal vein occlusion, diabetic retinopathy and retinopathy of prematurity. Ischemic retinopathy remains a common cause of visual impairment and blindness in the industrialized world due to relatively ineffective treatment. Oxygen-induced retinopathy (OIR) is an established model of retinopathy of prematurity associated with vascular cell injury culminating in microvascular degeneration, which precedes an abnormal neovascularization...
May 2005: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/15131178/development-of-a-bacteriophage-phage-replication-assay-for-diagnosis-of-pulmonary-tuberculosis
#15
COMPARATIVE STUDY
Ruth McNerney, Bupe S Kambashi, Juliana Kinkese, Ruth Tembwe, Peter Godfrey-Faussett
Successful infection and replication of bacteriophages is indicative of the presence of viable bacteria. We describe here the development of a bacteriophage replication assay for the detection of Mycobacterium tuberculosis by using mycobacteriophage D29. Optimization of phage inoculate and incubation times allowed highly sensitive detection of M. bovis BCG. Fewer than 10 CFU (100 CFU/ml) were detected. No false-positive results were observed in negative samples. Application of the assay to 496 sputum specimens in the National Reference Laboratory of Zambia produced sensitivity, specificity, and positive and negative predictive values of 44...
May 2004: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/14717358/fungi-aflatoxins-and-cyclopiazonic-acid-associated-with-peanut-retailing-in-botswana
#16
Fingani A Mphande, Bupe A Siame, Joanne E Taylor
Peanuts are important food commodities, but they are susceptible to fungal infestation and mycotoxin contamination. Raw peanuts were purchased from retail outlets in Botswana and examined for fungi and mycotoxin (aflatoxins and cyclopiazonic acid) contamination. Zygomycetes were the most common fungi isolated; they accounted for 41% of all the isolates and were found on 98% of the peanut samples. Among the Zygomycetes, Absidia corymbifera and Rhizopus stolonifer were the most common. Aspergillus spp. accounted for 35% of all the isolates, with Aspergillus niger being the most prevalent (20...
January 2004: Journal of Food Protection
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