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https://www.readbyqxmd.com/read/28213837/brief-report-meeting-the-needs-of-medically-hospitalized-adults-with-autism-a-provider-and-patient-toolkit
#1
Jocelyn Carter, Sarabeth Broder-Fingert, Ann Neumeyer, Ann Giauque, Ann Kao, Christiana Iyasere
In an effort to meet the needs of adults with autism spectrum disorder (ASD) while hospitalized, a team of experts and providers from Massachusetts General Hospital (MGH), MGH for Children as well as parents of individuals with ASD was sparked in 2013. This became a multidisciplinary collaborative, the MGH Autism Care Collaborative, to improve adult care for inpatients with ASD. The collaborative was created with three goals in mind: (1) to educate internal medicine adult inpatient providers and staff on the unique needs of adults with ASD when hospitalized; (2) to create ASD specific resources for internal medicine adult inpatient providers; (3) to optimize patient care from admission to discharge among adults with ASD admitted to internal medicine services...
February 17, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28208198/the-pulmonary-embolism-response-team-what-is-the-ideal-model
#2
Josanna Rodriguez-Lopez, Richard Channick
Treatment of patients with intermediate- and high-risk pulmonary embolism (PE) is a controversial area. Many therapeutic options exist, and deciding on appropriate treatment can be difficult. In addition, multiple specialties are often involved in the care of PE patients. To better organize the response to serious PE patients, several hospitals and academic centers across the United States, spearheaded by Massachusetts General Hospital, have created pulmonary embolism response teams (PERTs). The goal of a PERT is to have a single multidisciplinary team of experts in thromboembolic disease, who can respond rapidly to patients with acute PE, and offer consultation with the full spectrum of therapeutic options...
February 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28208140/first-diagnosis-of-atrial-fibrillation-at-the-time-of-stroke
#3
Leila H Borowsky, Susan Regan, Yuchiao Chang, Alison Ayres, Steven M Greenberg, Daniel E Singer
BACKGROUND: Atrial fibrillation (AF) is a major cause of ischemic stroke. Individuals with undiagnosed AF lack the stroke protection afforded by oral anticoagulants. We obtained a contemporary estimate of the percentage of AF patients newly diagnosed at the time of stroke. METHODS: We identified patients admitted to the Massachusetts General Hospital (MGH) from January 1, 2010 to December 31, 2013 with acute ischemic stroke and either previously or newly diagnosed AF using hospital stroke registry data and stroke and AF ICD-9 code searches of hospital databases...
February 17, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28207913/differentiating-residual-symptoms-of-depression-from-adverse-events-among-patients-initiating-treatment-with-an-antidepressant
#4
Marlene P Freeman, Lauren Fisher, Alisabet Clain, Richard Rabbitt, James Pooley, Lee Baer, Maurizio Fava
BACKGROUND: In treated patients with major depressive disorder (MDD), residual symptoms are common and challenging to disentangle from possible antidepressant side effects. Our objective was to prospectively differentiate between rates of residual symptoms and treatment-emergent side effects. METHODS: Participants in an episode of MDD were enrolled in a 6-week trial of an antidepressant. Assessments occurred at baseline and after 6 weeks of treatment, using the Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) and the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire (MGH CPFQ)...
February 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28194567/ultrastructural-characterization-of-mammary-analogue-secretory-carcinoma-of-the-salivary-glands-a-distinct-entity-from-acinic-cell-carcinoma
#5
Julie Guilmette, Gunnlaugur P Nielsen, William C Faquin, Martin Selig, Vânia Nosé, Anthony W S Chi, Peter M Sadow
Mammary analogue secretory carcinoma (MASC) of the salivary glands is a recently described neoplasm of the salivary glands with a characteristic morphology complemented by a specific cytogenetic translocation and gene rearrangements. Although immunophenotypic and cytogenetic differences allow for a more reliable distinction, ultrastructural features can also provide important information about the relationship between MASC, classic acinic cell carcinoma (AciCC), and AciCC intercalated duct cell-predominant variant...
February 13, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28192645/cytological-molecular-and-clinical-features-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-versus-invasive-forms-of-follicular-variant-of-papillary-thyroid-carcinoma
#6
Liena Zhao, Dora Dias-Santagata, Peter M Sadow, William C Faquin
BACKGROUND: The noninvasive follicular variant of papillary thyroid carcinoma (PTC) has an indolent clinical behavior in comparison with other PTCs, including the invasive follicular variant of papillary thyroid carcinoma (IFVPTC). Recently, the term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was introduced to emphasize the low biological potential of these tumors. This study compares clinical, cytological, and molecular features of NIFTP and IFVPTC...
February 13, 2017: Cancer
https://www.readbyqxmd.com/read/28159496/androgen-deprivation-with-or-without-radiation-therapy-for-clinically-node-positive-prostate-cancer-lin-cc-gray-pj-jemal-a-efstathiou-ja-surveillance-and-health-services-research-program-intramural-research-american-cancer-society-atlanta-ga-ccl-aj-department
#7
Eggener Scott
BACKGROUND: Clinically lymph node-positive (cN+) prostate cancer (PCa) is an often-fatal disease. Its optimal management remains largely undefined given a lack of prospective, randomized data to inform practice. We sought to describe modern practice patterns in the management of cN+PCa and assess the effect of adding radiation therapy (RT) to androgen deprivation therapy (ADT) on survival using the National Cancer Data Base. METHODS: Patients with cN+PCa and without distant metastases diagnosed between 2004 and 2011 were included...
January 31, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28158168/ultrasound-guided-radiofrequency-lesioning-of-the-articular-branches-of-the-femoral-nerve-for-the-treatment-of-chronic-post-arthroplasty-hip-pain
#8
David J Kim, Shiqian Shen, George M Hanna
BACKGROUND: Total hip arthroplasty (THA) is a common surgical treatment for several conditions of the hip. While the majority of patients obtain satisfactory results, many develop chronic post-arthroplasty hip pain that can be difficult to treat. OBJECTIVE: We evaluate the effectiveness of cooled (60°C) radiofrequency lesioning of the articular branches of the femoral nerve (ABFN) as a minimally invasive treatment for patients suffering from chronic post-arthroplasty hip pain...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28157692/bayesian-variable-selection-methods-for-matched-case-control-studies
#9
Josephine Asafu-Adjei, G Tadesse Mahlet, Brent Coull, Raji Balasubramanian, Michael Lev, Lee Schwamm, Rebecca Betensky
Matched case-control designs are currently used in many biomedical applications. To ensure high efficiency and statistical power in identifying features that best discriminate cases from controls, it is important to account for the use of matched designs. However, in the setting of high dimensional data, few variable selection methods account for matching. Bayesian approaches to variable selection have several advantages, including the fact that such approaches visit a wider range of model subsets. In this paper, we propose a variable selection method to account for case-control matching in a Bayesian context and apply it using simulation studies, a matched brain imaging study conducted at Massachusetts General Hospital, and a matched cardiovascular biomarker study conducted by the High Risk Plaque Initiative...
January 31, 2017: International Journal of Biostatistics
https://www.readbyqxmd.com/read/28143416/combination-therapy-with-rituximab-low-dose-cyclophosphamide-and-prednisone-for-idiopathic-membranous-nephropathy-a-case-series
#10
Frank B Cortazar, David E Leaf, Charles T Owens, Karen Laliberte, William F Pendergraft, John L Niles
BACKGROUND: Membranous nephropathy is a common cause of the nephrotic syndrome. Treatment with standard regimens fails to induce complete remission in most patients. We evaluated the efficacy of combination therapy with rituximab, low-dose, oral cyclophosphamide, and an accelerated prednisone taper (RCP) for the treatment of idiopathic membranous nephropathy. METHODS: We analyzed 15 consecutive patients with idiopathic membranous nephropathy treated with RCP at Massachusetts General Hospital...
February 1, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28141582/radiation-shielding-calculation-for-digital-breast-tomosynthesis-rooms-with-an-updated-workload-survey
#11
Kai Yang, Thomas J Schultz, Xinhua Li, Bob Liu
PURPOSE: To present shielding calculations for clinical digital breast tomosynthesis (DBT) rooms with updated workload data from a comprehensive survey and to provide reference shielding data for DBT rooms. METHODS: The workload survey was performed from eight clinical DBT (Hologic Selenia Dimensions) rooms at Massachusetts General Hospital (MGH) for the time period between 10/1/2014 and 10/1/2015. Radiation output related information tags from the DICOM header, including mAs, kVp, beam filter material and gantry angle, were extracted from a total of 310 421 clinical DBT acquisitions from the PACS database...
January 31, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28125073/the-association-between-igf-1-levels-and-the-histologic-severity-of-nonalcoholic-fatty-liver-disease
#12
Laura E Dichtel, Kathleen E Corey, Joseph Misdraji, Miriam A Bredella, Melanie Schorr, Stephanie A Osganian, Brian J Young, Joshua C Sung, Karen K Miller
OBJECTIVES: The mechanisms responsible for the development of nonalcoholic fatty liver disease (NAFLD) and progression to nonalcoholic steatohepatitis (NASH) are incompletely understood. Growing evidence suggests that growth hormone (GH) and insulin-like growth factor-1 (IGF-1) may have roles in the development and progression of NAFLD. We hypothesized that lower serum IGF-1 levels would be associated with increased liver fat accumulation, inflammation, and fibrosis in a group of meticulously phenotyped obese subjects with liver biopsies...
January 26, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28122904/evolution-of-cerebral-microbleeds-after-cranial-irradiation-in-medulloblastoma-patients
#13
Duangnapa Roongpiboonsopit, Hugo J Kuijf, Andreas Charidimou, Li Xiong, Anastasia Vashkevich, Sergi Martinez-Ramirez, Helen A Shih, Corey M Gill, Anand Viswanathan, Jorg Dietrich
OBJECTIVE: To characterize the temporal and spatial pattern of cerebral microbleeds (CMBs) after cranial irradiation in patients with medulloblastoma. METHODS: We retrospectively identified patients with medulloblastoma treated with craniospinal irradiation at the Massachusetts General Hospital between 1999 and 2015. Longitudinal MRI including T2*-weighted gradient-recalled echo (GRE) sequences were reviewed, and the prevalence, spatial pattern, and risk factors associated with CMBs were characterized...
January 25, 2017: Neurology
https://www.readbyqxmd.com/read/28121687/the-impact-of-administrative-burden-on-academic-physicians-results-of-a-hospital-wide-physician-survey
#14
Sandhya K Rao, Alexa B Kimball, Sara R Lehrhoff, Michael K Hidrue, Deborah G Colton, Timothy G Ferris, David F Torchiana
PURPOSE: To determine the characteristics of clinically active academic physicians most affected by administrative burden; the correlation between administrative burden, burnout, and career satisfaction among academic physicians; and the relative value and burden of specific administrative tasks. METHOD: The authors analyzed data from the 2014 Massachusetts General Physicians Organization Survey. Respondents reported the percentage of time they spent on patient-related administrative duties and rated the value and burden associated with specific administrative tasks...
February 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28117243/patient-perceptions-of-integrated-care-and-their-relationship-to-utilization-of-emergency-inpatient-and-outpatient-services
#15
Ashley-Kay Fryer, Mark W Friedberg, Ryan W Thompson, Sara J Singer
BACKGROUND: Patients with multiple chronic conditions have garnered particular attention from policymakers and health service researchers because these patients utilize more services and contribute disproportionally to rising health care expenses. The growing prevalence of patients with multiple chronic conditions has increased the importance of achieving better health care integration for this patient population. Patients may be well positioned to assess integration of their care, but the relationship between patients' perceptions of care integration and use of health services has not been studied...
January 21, 2017: Healthcare
https://www.readbyqxmd.com/read/28109989/low-glycemic-index-treatment-for-seizure-control-in-angelman-syndrome-a-case-series-from-the-center-for-dietary-therapy-of-epilepsy-at-the-massachusetts-general-hospital
#16
Olivia R Grocott, Katherine S Herrington, Heidi H Pfeifer, Elizabeth A Thiele, Ronald L Thibert
The low glycemic index treatment, a dietary therapy that focuses on glycemic index and reduced carbohydrate intake, has been successful in reducing seizure frequency in the general epilepsy population. Epilepsy is a common feature of Angelman syndrome and seizures are often refractory to multiple medications, especially in those with maternal deletions. Dietary therapy has become a more frequently used option for treating epilepsy, often in combination with other antiepileptic drugs, due to its efficacy and favorable side effect profile...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28108154/collaborative-design-of-a-health-care-experience-survey-for-persons-with-disability
#17
Lisa I Iezzoni, Holly Matulewicz, Sarah A Marsella, Kimberley S Warsett, Dennis Heaphy, Karen Donelan
BACKGROUND: When assessing results of health care delivery system reforms targeting persons with disability, quality metrics must reflect the experiences and perspectives of this population. OBJECTIVE: For persons with disability and researchers to develop collaboratively a survey that addresses critical quality questions about a new Massachusetts health care program for persons with disability dually-eligible for Medicare and Medicaid. METHODS: Persons with significant physical disability or serious mental health diagnoses participated fully in all research activities, including co-directing the study, co-moderating focus groups, performing qualitative analyses, specifying survey topics, cognitive interviewing, and refining survey language...
January 8, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28104099/coexisting-systemic-infections-in-patients-who-present-with-a-fall
#18
Alex Blair, Farrin A Manian
BACKGROUND: Although the causes of falls are legion, infectious disease-related factors are not commonly reported in the published literature. We investigated the characteristics of patients presenting to the hospital because of a fall and who were subsequently found to have a coexisting systemic infection (CSI). MATERIALS AND METHODS: This was a retrospective study performed at Massachusetts General Hospital, using the electronic database of adult patients receiving care during the period January 1, 2000 through December 31, 2014...
January 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28103841/a-two-site-two-arm-34-week-double-blind-parallel-group-randomized-controlled-trial-of-reduced-nicotine-cigarettes-in-smokers-with-mood-and-or-anxiety-disorders-trial-design-and-protocol
#19
Sophia I Allen, Jonathan Foulds, Gladys N Pachas, Susan Veldheer, Corinne Cather, Nour Azzouz, Shari Hrabovsky, Ahmad Hameed, Jessica Yingst, Erin Hammett, Jennifer Modesto, Nicolle M Krebs, Junjia Zhu, Jason Liao, Joshua E Muscat, John Richie, A Eden Evins
BACKGROUND: The U.S. Food and Drug Administration can set standards for cigarettes that could include reducing their nicotine content. Such a standard should improve public health without causing unintended serious consequences for sub-populations. This study evaluates the effect of progressive nicotine reduction in cigarettes on smoking behavior, toxicant exposure, and psychiatric symptoms in smokers with comorbid mood and/or anxiety disorders using a two-site, two-arm, double-blind, parallel group, randomized controlled trial (RCT) in four phases over 34 weeks...
January 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28101451/laparoscopic-vs-open-donor-nephrectomy-lessons-learnt-from-single-academic-center-experience
#20
Georgios Tsoulfas, Polyxeni Agorastou, Dicken S C Ko, Martin Hertl, Nahel Elias, A B Cosimi, Tatsuo Kawai
AIM: To compare laparoscopic and open living donor nephrectomy, based on the results from a single center during a decade. METHODS: This is a retrospective review of all living donor nephrectomies performed at the Massachusetts General Hospital, Harvard Medical School, Boston, between 1/1998 - 12/2009. Overall there were 490 living donors, with 279 undergoing laparoscopic living donor nephrectomy (LLDN) and 211 undergoing open donor nephrectomy (OLDN). Demographic data, operating room time, the effect of the learning curve, the number of conversions from laparoscopic to open surgery, donor preoperative glomerular filtration rate and creatinine (Cr), donor and recipient postoperative Cr, delayed graft function and donor complications were analyzed...
January 6, 2017: World Journal of Nephrology
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