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Katharina Platzbecker, Megan Behua Zhang, Tobias Kurth, Maira Isabella Rudolph, Katharina Eikermann-Haerter, Rami Burstein, Matthias Eikermann, Timothy Houle
Background Migraine has been identified as a risk factor of 30-day hospital readmission after surgery. We aimed to further characterize this association examining pain as a potentially migraine-associated, preventable reason for readmission. Hypothesis Compared to patients with no migraine, surgical patients with migraine are at increased risk of 30-day hospital readmission with an admitting diagnosis specifying pain. Methods This hospital registry study examined 150,710 patients aged 18 years and above, who underwent surgery with general anesthesia and mechanical ventilation between 2007 and 2015 at a tertiary care center and two affiliated community hospitals in Massachusetts, USA...
January 1, 2018: Cephalalgia: An International Journal of Headache
Alexander T Faje, Donald Lawrence, Keith Flaherty, Christine Freedman, Riley Fadden, Krista Rubin, Justine Cohen, Ryan J Sullivan
BACKGROUND: It remains unclear whether high doses of glucocorticoids have a negative impact on the efficacy of checkpoint inhibitors. To control for the potential association between immune-related adverse events (irAEs) and improved survival, this study examined a unique cohort of patients who had the same irAE treated with varying glucocorticoid doses. METHODS: In total, 98 patients with melanoma who had ipilimumab-induced hypophysitis were identified retrospectively in the Partners Healthcare system using an automated electronic medical record query tool...
July 5, 2018: Cancer
Jeffrey Landercasper
No abstract text is available yet for this article.
July 3, 2018: Annals of Surgical Oncology
Hamdi Eryilmaz, Kevin F Dowling, Franklin C Huntington, Anais Rodriguez-Thompson, Thomas W Soare, Lauren M Beard, Hang Lee, Jeffrey C Blossom, Randy L Gollub, Ezra Susser, Ruben C Gur, Monica E Calkins, Raquel E Gur, Theodore D Satterthwaite, Joshua L Roffman
Importance: Presently, 81 countries mandate the fortification of grain products with folic acid to lessen the risk of neural tube defects in the developing fetus. Epidemiologic data on severe mental illness suggest potentially broader effects of prenatal folate exposure on postnatal brain development, but this link remains unsubstantiated by biological evidence. Objective: To evaluate associations among fetal folic acid exposure, cortical maturation, and psychiatric risk in youths...
July 3, 2018: JAMA Psychiatry
Marlene P Freeman, Lina Góez-Mogollón, Kathryn A McInerney, Abigail C Davies, Taylor R Church, Alexandra Z Sosinsky, Olivia B Noe, Adele C Viguera, Lee S Cohen
OBJECTIVE: The goal of this analysis was to examine the effect of benzodiazepine use during pregnancy on maternal and neonatal outcomes in a cohort of women with psychiatric disorders. METHODS: 794 evaluable women from the Massachusetts General Hospital National Pregnancy Registry for Psychiatric Medications were followed across pregnancy (N = 144 exposed to benzodiazepines and N = 650 unexposed). Data obtained through maternal report and medical records included maternal outcomes (cesarean section, preeclampsia) and neonatal outcomes (birth weight, breathing difficulty, feeding difficulty, head circumference, 5-minute Apgar score, muscular and/or extrapyramidal symptoms, NICU admission, prematurity)...
May 29, 2018: General Hospital Psychiatry
Tim Korevaar, Lidia Minguez-Alarcón, Carmen Messerlian, Ralph de Poortere, Paige Williams, Maarten Broeren, Russ Hauser, Irene Souter
BACKGROUND: While overt thyroid disease is a well-known risk factor for infertility, the potential consequences of mild thyroid dysfunction or thyroid autoimmunity remain unknown. While experimental studies suggest a considerable role for thyroid hormone in the physiological mechanisms of ovarian reserve, translation of such findings to studies in humans remains sparse. A potential role for thyroid function in female reproduction is especially relevant when the cause of infertility remains unknown, such as in women with diminished ovarian reserve (DOR) or unexplained infertility...
June 26, 2018: Thyroid: Official Journal of the American Thyroid Association
Alyna T Chien, Sara L Toomey, Dennis Z Kuo, Jeanne Van Cleave, Amy J Houtrow, Megumi J Okumura, Matthew Y Westfall, Carter R Petty, Jessica A Quinn, Karen A Kuhlthau, Mark A Schuster
OBJECTIVE: To identify opportunities to improve care value for children with disabilities (CWD), we examined CWD prevalence within a commercially insured population and compared outpatient care quality and annual health plan spending levels for CWD relative to children with complex medical conditions without disabilities, children with chronic conditions that are not complex, and children without disabling, complex, or chronic conditions. METHODS: Cross-sectional study of 1,118,081 person-years of Blue Cross Blue Shield Massachusetts data for beneficiaries aged 1-19 years old during 2008-2012...
June 19, 2018: Academic Pediatrics
Patrick C Eschenfeldt, Uri Kartoun, Curtis R Heberle, Chung Yin Kong, Norman S Nishioka, Kenney Ng, Sagar Kamarthi, Chin Hur
BACKGROUND & AIMS: A common limiting factor in the throughput of gastrointestinal endoscopy units is the availability of space for patients to recover post-procedure. This study sought to identify predictors of abnormally long recovery time after colonoscopy performed with procedural sedation. In clinical research, this type of study would be performed using only one regression modeling approach. A goal of this study was to apply various "machine learning" techniques to see if better prediction could be achieved...
2018: PloS One
Jon E Grant, Samuel R Chamberlain
BACKGROUND: Immune dysregulation has been hypothesized to be important in the development and pathophysiology of compulsive disorders such as obsessive compulsive disorder (OCD), which has a high comorbid overlap with trichotillomania (both are OC-related disorders). The role of inflammation in the pathophysiology of trichotillomania has garnered little research to date. METHODS: Individuals with trichotillomania provided saliva sample for analysis of inflammatory cytokines...
June 19, 2018: Neuropsychobiology
Jessica Sheehan Tangren, Wan Ahmad Hafiz Wan Md Adnan, Camille E Powe, Jeffrey Ecker, Kate Bramham, Michelle A Hladunewich, Elizabeth Ankers, S Ananth Karumanchi, Ravi Thadhani
An episode of clinically recovered acute kidney injury (r-AKI) has been identified as a risk factor for future hypertension and cardiovascular disease. Our objective was to assess whether r-AKI was associated with future preeclampsia and other adverse pregnancy outcomes and to identify whether severity of AKI or time interval between AKI and pregnancy was associated with pregnancy complications. We conducted a retrospective cohort study of women who delivered infants between 1998 and 2016 at Massachusetts General Hospital...
June 18, 2018: Hypertension
Crystal M Sun, Joseph H Schwab, Francis J Hornicek
: Dr. Henry Mankin has made a profound impact in the fields of skeletal surgery and orthopaedics. In a career spanning over 50 years, Dr. Mankin conducted extensive research on and provided treatment for numerous patients with Gaucher disease and spinal disorders such as sacral chordomas. Dr. Mankin's prolific career includes many leadership positions in the field of skeletal surgery, including Chief of Orthopaedics at the Hospital for Joint Diseases and at Massachusetts General Hospital. He has touched the lives of over 18,000 patients with bone and soft tissue tumors and undoubtedly shaped the future of skeletal surgery...
June 8, 2018: Spine
Carmen Messerlian, Paige L Williams, Jennifer B Ford, Jorge E Chavarro, Lidia Mínguez-Alarcón, Ramace Dadd, Joseph M Braun, Audrey J Gaskins, John D Meeker, Tamarra James-Todd, Yu-Han Chiu, Feiby L Nassan, Irene Souter, John Petrozza, Myra Keller, Thomas L Toth, Antonia M Calafat, Russ Hauser
Background: The Environment and Reproductive Health (EARTH) Study is an ongoing prospective preconception cohort designed to investigate the impact of environmental, nutritional, and lifestyle factors among both women and men on fertility and pregnancy outcomes. Methods: The EARTH Study recruits women 18 to 45 years and men 18 to 55 years seeking fertility evaluation and treatment at the Massachusetts General Hospital (MGH) Fertility Center, Boston, USA. Women and men are eligible to join either independently or as a couple...
February 2018: Human reproduction open
Clayton B Hess, Daniel J Indelicato, Arnold C Paulino, William F Hartsell, Christine E Hill-Kayser, Stephanie M Perkins, Anita Mahajan, Nadia N Laack, Ralph P Ermoian, Andrew L Chang, Suzanne L Wolden, Victor S Mangona, Young Kwok, John C Breneman, John P Perentesis, Sara L Gallotto, Elizabeth A Weyman, Benjamin V M Bajaj, Miranda P Lawell, Beow Y Yeap, Torunn I Yock
Background/objectives: The Pediatric Proton Consortium Registry (PPCR) was established to expedite proton outcomes research in the pediatric population requiring radiotherapy. Here, we introduce the PPCR as a resource to the oncology community and provide an overview of the data available for further study and collaboration. Design/methods: A multi-institutional registry of integrated clinical, dosimetric, radiographic, and patient-reported data for patients undergoing proton radiation therapy was conceived in May 2010...
2018: Frontiers in Oncology
Axana Rodriguez-Torres, Meredith Murphy, Christina Kourkoulis, Kristin Schwab, Alison M Ayres, Charles J Moomaw, Soo Young Kwon, Jimmy V Berthaud, M Edip Gurol, Steven M Greenberg, Anand Viswanathan, Christopher D Anderson, Matthew Flaherty, Michael L James, Lee Birnbaum, Gene Yong Sung, Gunjan Parikh, Amelia K Boehme, Douglas Mayson, Kevin N Sheth, Chelsea Kidwell, Sebastian Koch, Michael Frankel, Carl D Langefeld, Fernando D Testai, Daniel Woo, Jonathan Rosand, Alessandro Biffi
OBJECTIVE: To clarify whether recurrence risk for intracerebral hemorrhage (ICH) is higher among black and Hispanic individuals and whether this disparity is attributable to differences in blood pressure (BP) measurements and their variability. METHODS: We analyzed data from survivors of primary ICH enrolled in 2 separate studies: (1) the longitudinal study conducted at Massachusetts General Hospital (n = 759), and (2) the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) study (n = 1,532)...
July 3, 2018: Neurology
Masako Nishiwaki, Miho Takayama, Hiroyoshi Yajima, Morihiro Nasu, Joel Park, Jian Kong, Nobuari Takakura
To investigate the acupuncture sensations elicited by the Japanese style of acupuncture, penetrating acupuncture and skin-touch placebo needles were randomly administered at various insertion depths (5 and 10 mm for the penetrating needles and 1 and 2 mm for the placebo needles) at LI4 to 50 healthy subjects. Among the 12 acupuncture sensations in the Massachusetts General Hospital Acupuncture Sensation Scale (MASS), "heaviness" was the strongest and most frequently reported sensation with the 10 mm needles, but not with the 5 mm needles...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Jean-Michel Dayer
Long-term cell cultures developed early in the twentieth century allowed identification in their supernatants of biological mediators subsequently defined as migration factors, interferons, lymphokines, monokines, cytokines and interleukins. In rheumatology, early in the 1930s, synovial cell cultures revealed two major distinct populations, i.e. synovial fibroblasts and monocyte-macrophages. Discovery of the interstitial collagenase (MMP-1) and its role in tissue destruction, such as in rheumatoid arthritis (RA), raised the question of the cellular source for this enzyme...
May 30, 2018: Arthritis Research & Therapy
Anil Can, Robert F Rudy, Victor M Castro, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T Weiss, Rose Du
BACKGROUND AND PURPOSE: Both low serum calcium and magnesium levels have been associated with the extent of bleeding in patients with intracerebral hemorrhage, suggesting hypocalcemia- and hypomagnesemia-induced coagulopathy as a possible underlying mechanism. We hypothesized that serum albumin-corrected total calcium and magnesium levels are associated with ruptured intracranial aneurysms. METHODS: The medical records of 4701 patients, including 1201 prospective patients, diagnosed at the Brigham and Women's Hospital and Massachusetts General Hospital between 1990 and 2016 were reviewed and analyzed...
July 2018: Stroke; a Journal of Cerebral Circulation
Feiby L Nassan, Jorge E Chavarro, Lidia Mínguez-Alarcón, Paige L Williams, Cigdem Tanrikut, Jennifer B Ford, Ramace Dadd, Melissa J Perry, Russ Hauser, Audrey J Gaskins
OBJECTIVE: We examined associations of residential distance to major roadways, as a proxy for traffic-related air pollution exposures, with sperm characteristics and male reproductive hormones. DESIGN: The cohort included 797 men recruited from Massachusetts General Hospital Fertility Center between 2000 and 2015 to participate in fertility research studies. MATERIALS AND METHODS: Men reported their residential addresses at enrollment and provided 1-6 semen samples and a blood sample during follow-up...
June 2018: International Journal of Hygiene and Environmental Health
David M Wang, Stefan Kraft, Pooyan Rohani, George F Murphy, Robert J Besaw, Pritesh S Karia, Frederick C Morgan, Chrysalyne D Schmults
Importance: Although the lip is considered a high-risk location in cutaneous squamous cell carcinoma (cSCC), it has not been established whether this risk stems from vermilion or cutaneous locations or both. Objective: To compare differences in risks of recurrence, metastasis, and death from cSCCs on the vermilion vs cutaneous lip. Design, Setting, and Participants: Retrospective cohort study of 303 patients with 310 primary cSCCs of the lip (138 cutaneous, 172 vermilion) diagnosed between 2000 and 2015 at 2 academic tertiary care centers in Boston, Massachusetts...
June 1, 2018: JAMA Dermatology
Ebrahim Haroon, Alexander W Daguanno, Bobbi J Woolwine, David R Goldsmith, Wendy M Baer, Evanthia C Wommack, Jennifer C Felger, Andrew H Miller
BACKGROUND: One third of patients with major depressive disorder (MDD) fail to respond to currently available antidepressant medications. Inflammation may contribute to treatment non-response through effects on neurotransmitter systems relevant to antidepressant efficacy. In post-hoc analyses, increased concentrations of inflammatory markers prior to treatment predict poor antidepressant response. However, limited data exists on whether depressed patients with multiple failed treatment trials in their current episode of depression exhibit increased inflammation...
May 19, 2018: Psychoneuroendocrinology
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