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https://www.readbyqxmd.com/read/29155610/seasonal-and-sexual-variation-in-metabolism-thermoregulation-and-hormones-in-the-big-brown-bat-eptesicus-fuscus
#1
Christopher S Richardson, Tim Heeren, Thomas H Kunz
In response to seasonal variation in energy availability and thermal environment, physiological and endocrine mechanisms have evolved in temperate zone animals. Seasonal changes in hormone activity affect metabolism, body temperature, and reproductive activity. We examined the seasonal regulatory role of hormones on basal metabolic rate (BMR) and regulatory nonshivering thermogenesis (RNST) in 98 female and 17 male adult Eptesicus fuscus (big brown bat). We measured BMR, RNST, and plasma levels of thyroid hormone (T3), leptin, and cortisol in bats captured in maternity colonies in eastern Massachusetts from May to August (from arousal from the hibernation phase to the prehibernation phase)...
January 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29153758/will-use-of-patient-portals-help-to-educate-and-communicate-with-patients-with-diabetes
#2
Sara L Jackson, Catherine M DesRoches, Dominick L Frosch, Sue Peacock, Natalia V Oster, Joann G Elmore
OBJECTIVE: Chronic disease management can require daily attention, and increased levels of patient activation and engagement. We examined whether patients with diabetes perceive a greater benefit to having electronic access to their doctors' clinic notes compared to patients without diabetes. We hypothesized that easy electronic access to these notes may help patients with self-care by improving education and communication. METHODS: Survey of patients with and without diabetes in Massachusetts and Pennsylvania about perceptions of potential benefits and risks of reading their visit notes via an electronic patient information portal...
November 8, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29149152/loss-of-efficacy-to-spinal-cord-stimulator-therapy-clinical-evidence-and-possible-causes
#3
Christopher M Aiudi, Roger Y Dunn, Sara M Burns, Sarah A Roth, Arissa Opalacz, Yi Zhang, Lucy Chen, Jianren Mao, Shihab U Ahmed
BACKGROUND: Although spinal cord stimulation (SCS) therapy has been shown to be efficacious in various pain conditions, the ability for SCS therapy to maintain long-term efficacy has been questioned. OBJECTIVE: The purpose of this study was to investigate whether a loss of efficacy (LOE) phenomenon exists with SCS therapy and to investigate if this phenomenon is more apparent in any specific patient population. STUDY DESIGN: A retrospective, observation chart review was conducted to evaluate the patient response to SCS therapy over time...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29146680/the-association-between-patient-experience-factors-and-likelihood-of-30-day-readmission-a-prospective-cohort-study
#4
Jocelyn Carter, Charlotte Ward, Deborah Wexler, Karen Donelan
OBJECTIVE: Hospital readmissions comprise nearly a third of US healthcare expenditures. Fifteen to 20 per cent of this spending is considered to be potentially preventable. Risk prediction models have suboptimal accuracy and typically exclude patient experience data. No studies have explored patient perceptions of the likelihood of readmission during index admission. Our objective was to examine associations between patient perceptions of care during index hospital admission and 30-day readmission...
November 16, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29138126/promoting-secondary-analysis-of-electronic-medical-records-in-china-summary-of-the-plagh-mit-critical-data-conference-and-health-datathon
#5
Peiyao Li, Chen Xie, Tom Pollard, Alistair Edward William Johnson, Desen Cao, Hongjun Kang, Hong Liang, Yuezhou Zhang, Xiaoli Liu, Yong Fan, Yuan Zhang, Wanguo Xue, Lixin Xie, Leo Anthony Celi, Zhengbo Zhang
Electronic health records (EHRs) have been widely adopted among modern hospitals to collect and track clinical data. Secondary analysis of EHRs could complement the traditional randomized control trial (RCT) research model. However, most researchers in China lack either the technical expertise or the resources needed to utilize EHRs as a resource. In addition, a climate of cross-disciplinary collaboration to gain insights from EHRs, a crucial component of a learning healthcare system, is not prevalent. To address these issues, members from the Massachusetts Institute of Technology (MIT) and the People's Liberation Army General Hospital (PLAGH) organized the first clinical data conference and health datathon in China, which provided a platform for clinicians, statisticians, and data scientists to team up and address information gaps in the intensive care unit (ICU)...
November 14, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29136189/serum-omega-3-fatty-acids-and-treatment-outcomes-among-women-undergoing-assisted-reproduction
#6
Y-H Chiu, A E Karmon, A J Gaskins, M Arvizu, P L Williams, I Souter, B R Rueda, R Hause, J E Chavarro
STUDY QUESTION: Are serum polyunsaturated fatty acids (PUFA) concentrations, including omega-3 (ω3-PUFA) and omega-6 (ω6-PUFA), related to ART outcomes? SUMMARY ANSWER: Serum levels of long-chain ω3-PUFA were positively associated with probability of live birth among women undergoing ART. WHAT IS KNOWN ALREADY: Intake of ω3-PUFA improves oocyte and embryo quality in animal and human studies. However, a recent cohort study found no relation between circulating ω3-PUFA levels and pregnancy rates after ART...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29129576/cardiometabolic-outcomes-and-mortality-in-medically-treated-primary-aldosteronism-a-retrospective-cohort-study
#7
Gregory L Hundemer, Gary C Curhan, Nicholas Yozamp, Molin Wang, Anand Vaidya
BACKGROUND: Mineralocorticoid receptor (MR) antagonists are the recommended medical therapy for primary aldosteronism. Whether this recommendation effectively reduces cardiometabolic risk is not well understood. We aimed to investigate the risk of incident cardiovascular events in patients with primary aldosteronism treated with MR antagonists compared with patients with essential hypertension. METHODS: We did a cohort study using patients from a research registry from Brigham and Women's Hospital, Massachusetts General Hospital, and their affiliated partner hospitals...
November 9, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29124043/activities-of-daily-living-measured-by-the-harvard-automated-phone-task-track-with-cognitive-decline-over-time-in-non-demented-elderly
#8
Gad A Marshall, Sarah L Aghjayan, Maria Dekhtyar, Joseph J Locascio, Kamal Jethwani, Rebecca E Amariglio, Keith A Johnson, Reisa A Sperling, Dorene M Rentz
Background: Impairment in activities of daily living is a major burden to both patients and caregivers. Mild impairment in instrumental activities of daily living is often seen at the stage of mild cognitive impairment. The field of Alzheimer's disease is moving toward earlier diagnosis and intervention and more sensitive and ecologically valid assessments of instrumental or complex activities of daily living are needed. The Harvard Automated Phone Task, a novel performance-based activities of daily living instrument, has the potential to fill this gap...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29122155/rituximab-hypersensitivity-evaluation-desensitization-and-potential-mechanisms
#9
Johnson T Wong, Aidan Long
BACKGROUND: Rituximab (Rituxan) hypersensitivity (RITS) can be severe and limits the ability to further administer the treatment. Understanding its pattern and desensitization may permit administration in difficult cases. OBJECTIVE: Analyze RITS patient characteristics, hypersensitivity pattern, and desensitization outcomes to optimize management. METHODS: Twenty-five patients with RITS were referred to the Allergy/Immunology Unit at Massachusetts General Hospital over 5 1/2 years...
November 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29121693/short-term-results-of-eluvia%C3%A2-paclitaxel-eluting-stent-in-external-iliac-and-femoropopliteal-lesions
#10
Maxime Elens, Robert Verhelst, Julien Possoz, Stefano Mastrobuoni, Valerie Lacroix, Parla Astarci
INTRODUCTION: The aim of this study was to independently evaluate the real-world performances of Eluvia™ paclitaxel drug-eluting stents (DES) (Boston Scientific, Marlborough, Massachusetts) for the treatment of external iliac and femoropopliteal artery lesions. MATERIALS AND METHODS: We prospectively collected, and retrospectively reviewed, data for all patients who underwent an endovascular treatment with an Eluvia™ DES for the treatment of an external iliac or femoropopliteal lesion...
November 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29110569/beliefs-about-smoking-related-lung-cancer-risk-among-low-socioeconomic-individuals-the-role-of-smoking-experience-and-interpersonal-communication
#11
Mesfin Awoke Bekalu, Sara Minsky, Kasisomayajula Viswanath
INTRODUCTION: Previous research has documented that smoking prevalence is generally high among low socioeconomic groups and that tobacco industries continue to target these population groups. However, little research has investigated the beliefs of individuals with low socioeconomic position (SEP) about the association between smoking and cancer risks. In this study, we examined beliefs about smoking-related lung cancer risk and the role of smoking experience, mass media exposure and health-related interpersonal communication among a sample of low SEP population...
November 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/29103103/heroin-use-is-associated-with-ruptured-saccular-aneurysms
#12
Anil Can, Victor M Castro, Yildirim H Ozdemir, Sarajune Dagen, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T Weiss, Rose Du
While cocaine use is thought to be associated with aneurysmal rupture, it is not known whether heroin use increases the risk of rupture in patients with non-mycotic saccular aneurysms. Our goal was to investigate the association between heroin and cocaine use and the rupture of saccular non-mycotic aneurysms. The medical records of 4701 patients with 6411 intracranial aneurysms, including 1201 prospective patients, diagnosed at the Brigham and Women's Hospital and Massachusetts General Hospital between 1990 and 2016 were reviewed and analyzed...
November 4, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29097016/volumetric-mri-analysis-of-plexiform-neurofibromas-in-neurofibromatosis-type-1-comparison-of-two-methods
#13
Wenli Cai, Seth M Steinberg, Miriam A Bredella, Gina Basinsky, Bhanusupriya Somarouthu, Scott R Plotkin, Jeffrey Solomon, Brigitte C Widemann, Gordon J Harris, Eva Dombi
OBJECTIVES: Plexiform neurofibromas (PNs) are complex, histologically benign peripheral nerve sheath tumors that are challenging to measure by simple line measurements. Computer-aided volumetric segmentation of PN has become the recommended method to assess response in clinical trials directed at PN. Different methods for volumetric analysis of PN have been developed. The goal of this study is to test the level of agreement in volume measurements and in interval changes using two separate methods of volumetric magnetic resonance imaging analysis...
October 30, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29084312/effect-of-patient-navigation-and-financial-incentives-on-smoking-cessation-among-primary-care-patients-at-an-urban-safety-net-hospital-a-randomized-clinical-trial
#14
Karen E Lasser, Lisa M Quintiliani, Ve Truong, Ziming Xuan, Jennifer Murillo, Cheryl Jean, Lori Pbert
Importance: While the proportion of adults who smoke cigarettes has declined substantially in the past decade, socioeconomic disparities in cigarette smoking remain. Few interventions have targeted low socioeconomic status (SES) and minority smokers in primary care settings. Objective: To evaluate a multicomponent intervention to promote smoking cessation among low-SES and minority smokers. Design, Setting, and Participants: For this prospective, unblinded, randomized clinical trial conducted between May 1, 2015, and September 4, 2017, adults 18 years and older who spoke English, smoked 10 or more cigarettes per day in the past week, were contemplating or preparing to quit smoking, and had a primary care clinician were recruited from general internal medicine and family medicine practices at 1 large safety-net hospital in Boston, Massachusetts...
October 30, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29078988/gestational-weight-gain-and-pre-pregnancy-body-mass-index-associated-with-second-generation-antipsychotic-drug-use-during-pregnancy
#15
Marlene P Freeman, Alexandra Z Sosinsky, Lina Goez-Mogollon, Gina M Savella, Danna Moustafa, Adele C Viguera, Lee S Cohen
BACKGROUND: Obesity during pregnancy is the most common high-risk obstetric condition, resulting in increased rates of adverse maternal and neonatal outcomes. Individuals with psychiatric disorders have a higher risk of obesity than the general population, but data regarding implications of obesity in women with psychiatric disorders are sparse. OBJECTIVE: The objective of this study was to assess pre-pregnancy weights and gestational weight gain in women who were exposed to second-generation antipsychotics (SGAs) during pregnancy compared to controls...
September 21, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29078965/investigation-of-the-phenomenon-of-propagated-sensation-along-the-channels-in-the-upper-limb-following-administration-of-acupuncture-and-mock-laser
#16
Shohreh Razavy, Marcus Gadau, Shi Ping Zhang, Fu Chun Wang, Sergio Bangrazi, Christine Berle, Mahrita Harahap, Tie Li, Wei Hong Li, Christopher Zaslawski
BACKGROUND: Similar to De Qi psychophysical responses, propagated sensation along the channels (PSC) is considered an important phenomenon in traditional Chinese acupuncture. In acupuncture clinical trials, different acupuncture manipulation techniques are used to enhance the propagation of sensation along the channels to facilitate an optimum therapeutic result. AIM: To examine and compare the PSC reported by participants in a clinical trial following the administration of acupuncture and inactive mock laser...
October 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29078865/effectiveness-safety-and-predictors-of-response-to-botulinum-toxin-type-a-in-refractory-masticatory-myalgia-a-retrospective-study
#17
Shehryar N Khawaja, Steven J Scrivani, Nicole Holland, David A Keith
PURPOSE: Masticatory muscle pain disorders respond well to conservative therapy; however, in some patients the pain becomes refractory. Botulinum toxin type A (BoT-A) therapy has been shown to be an effective modality in the management of refractory headache disorders. Conversely, there are conflicting reports in the literature regarding the efficacy, safety, and predictors of therapeutic response to BoT-A therapy for management of refractory masticatory muscle pain. MATERIALS AND METHODS: We performed a retrospective chart review of patients who underwent at least 2 injection cycles of 100 U of BoT-A for refractory masticatory myalgia in the Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, between May 2012 and June 2016...
November 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29077936/urinary-concentrations-of-3-diethylcarbamoyl-benzoic-acid-dcba-a-major-metabolite-of-n-n-diethyl-m-toluamide-deet-and-semen-parameters-among-men-attending-a-fertility-center
#18
Thalia R Segal, Lidia Mínguez-Alarcón, Yu-Han Chiu, Paige L Williams, Feiby L Nassan, Ramace Dadd, María Ospina, Antonia M Calafat, Russ Hauser
STUDY QUESTION: Are specific gravity (SG)-adjusted urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA) associated with semen parameters among men attending an academic fertility center? SUMMARY ANSWER: Our study did not demonstrate any association between SG-adjusted urinary DCBA concentrations and semen parameters among men attending an academic fertility center. WHAT IS KNOWN ALREADY: N,N-Diethyl-m-toluamide (DEET) is the most common active ingredient in consumer insect repellents...
October 25, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29072783/living-alone-and-discharge-to-skilled-nursing-facility-care-after-hospitalization-in-older-adults
#19
Daniel E Lage, Michael C Jernigan, Yuchiao Chang, David C Grabowski, John Hsu, Joshua P Metlay, Sachin J Shah
BACKGROUND/OBJECTIVES: Community-based older adults are increasingly living alone. When they become ill, they might need greater support from the healthcare system than would those who live with others. There also has been a growing concern about the high use of postacute care such as skilled nursing facility (SNF) care and the level of variation in this use between hospitals and regions. Our objective was to examine whether living alone contributed to the risk of being discharged to a SNF...
October 26, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29069090/the-meld-plus-a-generalizable-prediction-risk-score-in-cirrhosis
#20
Uri Kartoun, Kathleen E Corey, Tracey G Simon, Hui Zheng, Rahul Aggarwal, Kenney Ng, Stanley Y Shaw
BACKGROUND AND AIMS: Accurate assessment of the risk of mortality following a cirrhosis-related admission can enable health-care providers to identify high-risk patients and modify treatment plans to decrease the risk of mortality. METHODS: We developed a post-discharge mortality prediction model for patients with a cirrhosis-related admission using a population of 314,292 patients who received care either at Massachusetts General Hospital (MGH) or Brigham and Women's Hospital (BWH) between 1992 and 2010...
2017: PloS One
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