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https://www.readbyqxmd.com/read/29054049/individual-variability-in-clinical-effect-and-tolerability-of-opioid-analgesics-importance-of-drug-interactions-and-pharmacogenetics
#1
REVIEW
Vigdis Solhaug, Espen Molden
BACKGROUND: As pain is often a comorbid condition, many patients use opioid analgesics in combination with several other drugs. This implies a generally increased risk of drug interactions, which along with inherent pharmacogenetic variability and other factors may cause differences in therapeutic response of opioids. AIM: To provide an overview of interactions and pharmacogenetic variability of relevance for individual differences in effect and tolerability of opioid analgesics, which physicians and other healthcare professionals should be aware of in clinical practice...
October 17, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29054032/constipation-and-other-common-symptoms-reported-by-women-and-men-in-methadone-and-buprenorphine-maintenance-treatment
#2
Paul S Haber, Mahmoud Elsayed, David Espinoza, Nicholas Lintzeris, Anne-Sophie Veillard, Richard Hallinan
BACKGROUND: Opioid substitution treatment (OST) is often continued long-term and, therefore, opioid-associated symptoms are of interest. Symptoms associated with methadone maintenance treatment (MMT) in men are well described, but there are fewer reports concerning symptoms associated with buprenorphine maintenance treatment (BMT) and very few reports among women. METHOD: Recipients of BMT (n=113) and MMT (n=184), non-opioid users (n=105) and opioid users not receiving OST (n=87) completed the Patient Assessment of Constipation (PAC-SYM) and a general symptom checklist...
October 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29053731/determination-of-%C3%AE-%C3%AE-and-%C3%AE%C2%BA-opioid-receptors-in-forebrain-cortex-of-rats-exposed-to-morphine-for-10-days-comparison-with-animals-after-20-days-of-morphine-withdrawal
#3
Hana Ujcikova, Martina Hlouskova, Kristina Cechova, Katerina Stolarova, Lenka Roubalova, Petr Svoboda
BACKGROUND: Chronic exposure of mammalian organism to morphine results in adaption to persistent high opioid tone through homeostatic adjustments. Our previous results indicated that in the frontal brain cortex (FBC) of rats exposed to morphine for 10 days, such a compensatory adjustment was detected as large up-regulation of adenylylcyclases I (8-fold) and II (2.5-fold). The other isoforms of AC (III-IX) were unchanged. Importantly, the increase of ACI and ACII was reversible as it disappeared after 20 days of morphine withdrawal...
2017: PloS One
https://www.readbyqxmd.com/read/29053268/synthesis-pharmacology-and-molecular-modeling-studies-on-6-desoxo-n-methylmorphinans-as-potent-%C3%A2%C2%B5-opioid-receptor-agonists
#4
Maria Dumitrascuta, Tanila Ben Haddou, Elena Guerrieri, Stefan M Noha, Lea Schläfer, Helmut Schmidhammer, Mariana Spetea
Position 6 of the morphinan skeleton plays a key role on the µ-opioid receptor (MOR) activity in vitro and in vivo. We describe the consequence of the 6-carbonyl group deletion in N-methylmorphinan-6-ones 1-4 on ligand-MOR interaction, signaling and antinociception. While 6-desoxo compounds 1a, 2a and 4a show similar profiles to their 6-keto counterparts, the 6-desoxo-14-benzyloxy substituted 3a displays significantly increased MOR binding and agonist potency, and a distinct binding mode than its analogue 3...
October 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29052693/medicare-formulary-coverage-restrictions-for-prescription-opioids-2006-to-2015
#5
Elizabeth A Samuels, Joseph S Ross, Sanket S Dhruva
No abstract text is available yet for this article.
October 10, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29052613/dynorphin-counteracts-orexin-in-the-paraventricular-nucleus-of-the-thalamus-cellular-and-behavioral-evidence
#6
Alessandra Matzeu, Marsida Kallupi, Olivier George, Paul Schweitzer, Rémi Martin-Fardon
The orexin (Orx) system plays a critical role in drug addiction and reward-related behaviors. The dynorphin (Dyn) system promotes depressive-like behavior and plays a key role in the aversive effects of stress. Orx and Dyn are co-released and have opposing functions in reward and motivation in the ventral tegmental area (VTA). Previous studies suggested that OrxA transmission in the posterior paraventricular nucleus of the thalamus (pPVT) participates in cocaine-seeking behavior. This study determined whether Orx and Dyn interact in the pPVT...
October 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29051703/buprenorphine-naloxone-maintenance-therapy-an-observational-retrospective-report-on-the-effect-of-dose-on-18%C3%A2-months-retention-in-an-office-based-treatment-program
#7
Theodore V Parran, A G Mace, Yael J Dahan, Christopher A Adelman, Mykola Kolganov
CONTEXT AND OBJECTIVE: Buprenorphine has been available with few reports of the dose range necessary to adequately maintain patients. We report on the effect of 8 mg/d versus 16 mg/d of buprenorphine on long-term patient retention in office-based opioid maintenance (OBOMT). DESIGN SETTING AND PARTICIPANTS: Case series, at an urban hospital-based primary care clinic providing OBOMT to 157 opiate-dependent, low socioeconomic status, uninsured, nonhomeless patients...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/29051663/%C3%AE%C2%BA-casein-as-a-source-of-short-chain-bioactive-peptides-generated-by-lactobacillus-helveticus
#8
Katarzyna Skrzypczak, Waldemar Gustaw, Dominik Szwajgier, Emilia Fornal, Adam Waśko
This paper explores the ability of Lactobacillus helveticus strains to release sequences of short biologically active peptides (containing 2-10 amino acid residues) from casein. The proteolytic enzymes of the tested strains exhibit different patterns of cleavage of CN fractions. The modification of κ-casein (κ-CN) with pyrrolidone carboxylic acid inhibits the proteolytic activity of strains L. helveticus 141 and the reference strain (DSMZ 20075), while the modification with phosphothreonine inhibits enzymes of all the tested bacteria...
October 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29051174/overprescribing-is-major-contributor-to-opioid-crisis
#9
EDITORIAL
Martin A Makary, Heidi N Overton, Peiqi Wang
No abstract text is available yet for this article.
October 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29051173/don-t-demonise-prescription-opioids
#10
Bob Roehr
No abstract text is available yet for this article.
October 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29051156/how-inappropriate-prescribing-prompted-the-opioid-addiction-ravaging-small-town-america
#11
Michael McCarthy
No abstract text is available yet for this article.
October 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29050999/chemical-capture-of-impala-aepyceros-melampus-a-review-of-factors-contributing-to-morbidity-and-mortality
#12
REVIEW
Gareth E Zeiler, Leith C R Meyer
OBJECTIVE: To review the factors that contribute to morbidity and mortality of impala undergoing chemical capture, and discuss how they are potentially mitigated. DATABASES USED: PubMed, Science Direct, Google Scholar and Onderstepoort Veterinary Academic Hospital records. CONCLUSIONS AND CLINICAL RELEVANCE: Impala are an important species of antelope in Africa and are often captured during management procedures, veterinary interventions and research projects...
May 18, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29050538/evaluation-of-the-head-and-neck-cancer-patient-population-and-the-incidence-of-hospitalization-at-an-academic-medical-center
#13
Lindsay A Hazelden, Matthew J Newman, Stephanie Shuey, Julie M Waldfogel, Victoria T Brown
Purpose Patients with head and neck cancer are at risk for disease- and treatment-related toxicities that may be severe enough to require hospitalization. The risk factors associated with hospitalization in these patients are not well defined. Methods We conducted a single-center, retrospective observational study of patients with head and neck cancer receiving chemotherapy at an academic medical center infusion clinic in a one-year period. The primary objective was to characterize the head and neck cancer population at an academic medical center...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29050061/-perioperative-anaphylaxia-on-drugs
#14
Wolfgang Pfützner, Hinnerk Wulf
The diagnostic evaluation of perioperative anaphylaxia is of great importance for the medical care of the affected persons in the context of renewed interventions in general anesthesia. The most frequent triggers include muscle relaxants, antibiotics, latex and analgesics of the type of the cyclooxygenase inhibitors, but other perioperatively administered drugs such as opioids, anesthetics, benzodiazepines, dyes, disinfectants and even corticosteroids or drug additives may also be the cause in rare cases. The most important aim is therefore the identification of the responsible drug, for which a near-time allergological diagnosis should be carried out within the first 4 weeks to 6 months after the reaction...
October 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29049548/multimodal-analgesia-in-outpatient-head-and-neck-surgery-a-feasibility-and-safety-study
#15
Justin Oltman, Oleg Militsakh, Mark D'Agostino, Brittany Kauffman, Robert Lindau, Andrew Coughlin, William Lydiatt, Daniel Lydiatt, Russell Smith, Aru Panwar
Importance: Perioperative analgesia strategies that rely solely on narcotics may contribute to adverse effects and concerns about opioid abuse or dependence. Multimodal analgesia protocols incorporating nonnarcotic agents may reduce the need for postoperative narcotic use. Objective: To evaluate the feasibility and safety of a multimodal analgesia protocol for outpatient head and neck surgical procedures and to identify the association of the multimodal analgesia protocol with postoperative pain perception scores and patient satisfaction...
October 19, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29049522/ten-steps-the-federal-government-should-take-now-to-reverse-the-opioid-addiction-epidemic
#16
Andrew Kolodny, Thomas R Frieden
No abstract text is available yet for this article.
October 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29049469/the-effectiveness-of-injectable-extended-release-naltrexone-vs-daily-buprenorphine-naloxone-for-opioid-dependence-a-randomized-clinical-noninferiority-trial
#17
Lars Tanum, Kristin Klemmetsby Solli, Zill-E-Huma Latif, Jurate Šaltyte Benth, Arild Opheim, Kamni Sharma-Haase, Peter Krajci, Nikolaj Kunøe
Importance: To date, extended-release naltrexone hydrochloride has not previously been compared directly with opioid medication treatment (OMT), currently the most commonly prescribed treatment for opioid dependence. Objective: To determine whether treatment with extended-release naltrexone will be as effective as daily buprenorphine hydrochloride with naloxone hydrochloride in maintaining abstinence from heroin and other illicit substances in newly detoxified individuals...
October 18, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29049282/behavioral-intervention-to-reduce-opioid-overdose-among-high-risk-persons-with-opioid-use-disorder-a-pilot-randomized-controlled-trial
#18
Phillip Oliver Coffin, Glenn-Milo Santos, Tim Matheson, Emily Behar, Chris Rowe, Talia Rubin, Janelle Silvis, Eric Vittinghoff
OBJECTIVE: The United States is amidst an opioid epidemic, including synthetic opioids that may result in rapid death, leaving minimal opportunity for bystander rescue. We pilot tested a behavioral intervention to reduce the occurrence of opioid overdose among opioid dependent persons at high-risk for subsequent overdose. MATERIALS AND METHODS: We conducted a single-blinded randomized-controlled trial of a repeated dose motivational interviewing intervention (REBOOT) to reduce overdose versus treatment as usual, defined as information and referrals, over 16 months at the San Francisco Department of Public Health from 2014-2016...
2017: PloS One
https://www.readbyqxmd.com/read/29049278/illicit-drug-use-illicit-drug-use-disorders-and-drug-overdose-deaths-in-metropolitan-and-nonmetropolitan-areas-united-states
#19
Karin A Mack, Christopher M Jones, Michael F Ballesteros
PROBLEM/CONDITION: Drug overdoses are a leading cause of injury death in the United States, resulting in approximately 52,000 deaths in 2015. Understanding differences in illicit drug use, illicit drug use disorders, and overall drug overdose deaths in metropolitan and nonmetropolitan areas is important for informing public health programs, interventions, and policies. REPORTING PERIOD: Illicit drug use and drug use disorders during 2003-2014, and drug overdose deaths during 1999-2015...
October 20, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29049124/surgery-induced-opioid-dependence-adding-fuel-to-the-fire
#20
Lauren K Dunn, Marcel E Durieux, Edward C Nemergut, Bhiken I Naik
No abstract text is available yet for this article.
November 2017: Anesthesia and Analgesia
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