keyword
MENU ▼
Read by QxMD icon Read
search

Opioides

keyword
https://www.readbyqxmd.com/read/29909567/paravertebral-blocks-reduce-the-risk-of-postoperative-urinary-retention-in-inguinal-hernia-repair
#1
E Bojaxhi, J Lee, S Bowers, R D Frank, S H Pak, A Rosales, S Padron, R A Greengrass
PURPOSE: Inguinal hernia repair and general anesthesia (GA) are known risk factors for urinary retention. Paravertebral blocks (PVBs) have been utilized to facilitate enhanced recovery after surgery. We evaluate the benefit of incorporating PVBs into our anesthetic technique in a large cohort of ambulatory patients undergoing inguinal hernia repair. METHODS: Records of 619 adults scheduled for ambulatory inguinal hernia repair between 2010 and 2015 were reviewed and categorized based on anesthetic and surgical approach [GA and open (GAO), GA and laparoscopic (GAL), PVB and open (PVBO), and GA/PVB and open (GA/PVBO)]...
June 16, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29909433/pharmacokinetics-of-fentanyl-sublingual-spray-in-opioid-na%C3%A3-ve-participants-results-of-a-phase-1-multiple-ascending-dose-study
#2
Richard L Rauck, D Alexander Oh, Neil Singla, Christian Koch, Neha Parikh, Srinivas Nalamachu, Jin Yu, Steven James
BACKGROUND AND OBJECTIVES: Fentanyl sublingual spray may be a viable alternative to intravenous (IV) opioids for the treatment of acute pain. As patients with acute pain may include those who have limited prior exposure to opioids, this phase 1, open-label, randomized, multiple ascending-dose study was conducted to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability of multiple doses of fentanyl sublingual spray in opioid-naïve participants. This article primarily reports the pharmacokinetics results...
June 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29909354/screening-emergency-department-patients-for-opioid-drug-use-a-qualitative-systematic-review
#3
REVIEW
Preet Kaur Sahota, Siri Shastry, Dana B Mukamel, Linda Murphy, Narisu Yang, Shahram Lotfipour, Bharath Chakravarthy
INTRODUCTION: The opioid drug epidemic is a major public health concern and an economic burden in the United States. The purpose of this systematic review is to assess the reliability and validity of screening instruments used in emergency medicine settings to detect opioid use in patients and to assess psychometric data for each screening instrument. METHODS: PubMed/MEDLINE, PsycINFO, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, Cumulative Index to Nursing and Allied Health Literature and ClinicalTrials...
May 24, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29909262/behavioral-evidence-for-sex-steroids-hypersensitivity-in-castrated-male-canaries
#4
Olesya Shevchouk, Samar Ghorbanpoor, Ed Smith, Philippe Liere, Michael Schumacher, Gregory F Ball, Charlotte A Cornil, Jacques Balthazart
In seasonally breeding songbirds such as canaries, singing behavior is predominantly under the control of testosterone and its metabolites. Short daylenths in the fall that break photorefractoriness are followed by increasing daylengths in spring that activate singing via both photoperiodic and hormonal mechanisms. However, we observed in a group of castrated male Fife fancy canaries maintained for a long duration under a short day photoperiod a large proportion of subjects that sang at high rates. This singing rate was not correlated with variation in the low circulating concentrations of testosterone...
June 14, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29909236/antiepileptic-drugs-as-analgesics-adjuvants-in-inflammatory-pain-current-preclinical-evidence
#5
REVIEW
Tomić Maja, Pecikoza Uroš, Micov Ana, Vučković Sonja, Stepanović-Petrović Radica
Inflammatory pain is the most common type of pain that is treated clinically. The use of currently available treatments (classic analgesics - NSAIDs, paracetamol and opioids) is limited by insufficient efficacy and/or side effects/tolerance development. Antiepileptic drugs (AEDs) are widely used in neuropathic pain treatment, but there is substantial preclinical evidence on their efficacy against inflammatory pain, too. In this review we focus on gabapentinoids (gabapentin and pregabalin) and dibenzazepine AEDs (carbamazepine, oxcarbazepine, and recently introduced eslicarbazepine acetate) and their potential for relieving inflammatory pain...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29908763/acceptability-and-feasibility-of-naloxone-prescribing-in-primary-care-settings-a-systematic-review
#6
REVIEW
Emily Behar, Rita Bagnulo, Phillip O Coffin
Naloxone access through established healthcare settings is critical to responding to the opioid crisis. We conducted a systematic review to assess the acceptability and feasibility of prescribing naloxone to patients in primary care. We queried PubMed, EmBase and CINAHL for US-based, peer-reviewed, full-length, original articles relating to acceptability or feasibility of prescribing naloxone in primary care. Searches yielded 270 unduplicated articles; one analyst reviewed all titles and abstracts. Two analysts independently reviewed eligible articles for study design, study outcome, and acceptability and/or feasibility...
June 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29908442/benzomorphan-skeleton-a-versatile-scaffold-for-different-targets-a-comprehensive-review
#7
REVIEW
Rita Turnaturi, Lucia Montenegro, Agostino Marrazzo, Rosalba Parenti, Lorella Pasquinucci, Carmela Parenti
Despite the fact that the benzomorphan skeleton has mainly been employed in medicinal chemistry for the development of opioid analgesics, it is a versatile structure. Its stereochemistry, as well as opportune modifications at the phenolic hydroxyl group and at the basic nitrogen, play a pivotal role addressing the benzomorphan-based compounds to a specific target. In this review, we describe the structure activity-relationships (SARs) of benzomorphan-based compounds acting at sigma 1 receptor (σ1R), sigma 2 receptor (σ2R), voltage-dependent sodium channel, N-Methyl-d-Aspartate (NMDA) receptor-channel complex and other targets...
June 7, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908137/personality-high-risk-behaviors-and-elevated-risk-of-unintentional-deaths-related-to-drug-poisoning-among-individuals-with-spinal-cord-injury
#8
James S Krause, Yue Cao, Nicole D DiPiro, Emma Cuddy
OBJECTIVE: To identify risk and protective factors for unintentional death related to drug poisoning from prescription medications, including opioid-related deaths, and death due to all other causes among participants with spinal cord injury (SCI). DESIGN: Prospective cohort study. SETTING: Large specialty hospital in the Southeastern United States. PARTICIPANTS: Two cohorts of SCI participants, totaling 3070 adults (>18 years old) with chronic (>1 year) traumatic SCI...
June 13, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29907903/the-chemokine-ccl4-mip-1%C3%AE-evokes-antinociceptive-effects-in-mice-a-role-for-cd4-lymphocytes-and-met-enkephalin
#9
Mario García-Domínguez, Ana Lastra, Alicia R Folgueras, Rafael Cernuda-Cernuda, María Teresa Fernández-García, Agustín Hidalgo, Luis Menéndez, Ana Baamonde
In the present study, we characterize the antinociceptive effects produced by the chemokine CCL4 in mice. The intraplantar administration of very low doses of CCL4 (0.1-3 pg) produced bilateral antinociception assessed by the unilateral hot-plate test (UHP) without evoking chemotactic responses at the injection site. Moreover, the subcutaneous administration of CCL4 (3-100 pg/kg) also yielded bilateral antinociception in the UHP and the paw pressure test and reduced the number of spinal neurons that express Fos protein in response to noxious stimulation...
June 15, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29907621/heroin-use-is-associated-with-aa-type-kidney-amyloidosis-in-the-pacific-northwest
#10
Arjun Sharma, Priyanka Govindan, Mirna Toukatly, Jack Healy, Connor Henry, Steve Senter, Behzad Najafian, Bryan Kestenbaum
BACKGROUND AND OBJECTIVES: AA-type kidney amyloidosis is classically associated with chronic autoimmune or inflammatory disorders. However, some urban centers have reported a high prevalence of injection drug use among patients with kidney AA amyloidosis. Previous reports lack control groups to quantify associations and most predate the opioid epidemic in the United States. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a case-control study of 38 patients with biopsy-confirmed kidney AA amyloidosis and 72 matched control individuals without this condition from two large hospital systems in Seattle, Washington...
June 15, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29907456/state-of-the-art-analgesia-recent-developments-in-pharmacological-approaches-to-acute-pain-management-in-dogs-and-cats-part-1
#11
REVIEW
C A Bradbrook, L Clark
There has been considerable interest in acute pain management over recent years, focusing on pain assessment, pharmacological and non-pharmacological interventions. The evidence base for our clinical decision making and treatment of patients is increasing and becoming more robust. There is still a tendency to base some aspects of pain management on poor quality evidence and this requires further input in years to come. With new literature come new ideas and this review will detail the current knowledge base behind pharmacological management of acute pain in dogs and cats...
June 6, 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29907226/paravertebral-block-associated-with-decreased-opioid-use-and-less-nausea-and-vomiting-after-reduction-mammaplasty
#12
David D Rivedal, Harry S Nayar, Jacqueline S Israel, Glen Leverson, Andrew J Schulz, Tamara Chambers, Ahmed M Afifi, Jocelyn M Blake, Samuel O Poore
BACKGROUND: In light of data finding that postoperative pain, nausea, and vomiting worsen outcomes, a renewed emphasis has been placed on optimizing the perioperative period. Use of preoperative paravertebral block (PVB) has been shown to reduce opioid administration and postoperative nausea and vomiting (PONV) in many surgical populations, though its role in reduction mammaplasty remains undefined. Therefore, we seek to evaluate PVB as an adjunct to general anesthesia (GA) for reduction mammaplasty...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907211/comparison-of-dexmedetomidine-versus-propofol-on-hemodynamics-in-surgical-critically-ill-patients
#13
Ya-Fei Chang, Anne Chao, Po-Yuan Shih, Yen-Chun Hsu, Chen-Tse Lee, Yu-Wen Tien, Yu-Chang Yeh, Lee-Wei Chen
BACKGROUND: Sedation with dexmedetomidine and propofol may cause hypotension or bradycardia. This study aimed to compare the effects of dexmedetomidine and propofol on hemodynamics and clinical outcomes in surgical intensive care unit (ICU) patients after major abdominal surgery. MATERIALS AND METHODS: Enrolled patients were randomly allocated to the dexmedetomidine or propofol group. Cardiac index was measured using a continuous noninvasive cardiac output monitor on the basis of chest bioreactance...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907207/utilization-and-effectiveness-of-multimodal-discharge-analgesia-for-postoperative-pain-management
#14
Karishma Desai, Ian Carroll, Steven M Asch, Tina Seto, Kathryn M McDonald, Catherine Curtin, Tina Hernandez-Boussard
BACKGROUND: Although evidence-based guidelines recommend a multimodal approach to pain management, limited information exists on adherence to these guidelines and its association with outcomes in a generalized population. We sought to assess the association between discharge multimodal analgesia and postoperative pain outcomes in two diverse health care settings. METHODS: We evaluated patients undergoing four common surgeries associated with high pain in electronic health records from an academic hospital (AH) and Veterans Health Administration (VHA)...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906316/interventions-for-the-reduction-of-prescribed-opioid-use-in-chronic-non-cancer-pain
#15
REVIEW
Phyllis B Whitehead
No abstract text is available yet for this article.
June 2018: Research in Nursing & Health
https://www.readbyqxmd.com/read/29905915/network-research-experiences-in-new-york-and-eastern-europe-lessons-for-the-southern-us-in-understanding-hiv-transmission-dynamics
#16
REVIEW
Samuel R Friedman, Leslie Williams, April M Young, Jennifer Teubl, Dimitrios Paraskevis, Evangelia Kostaki, Carl Latkin, Danielle German, Pedro Mateu-Gelabert, Honoria Guarino, Tetyana I Vasylyeva, Britt Skaathun, John Schneider, Ania Korobchuk, Pavlo Smyrnov, Georgios Nikolopoulos
PURPOSE: This paper presents an overview of different kinds of risk and social network methods and the kinds of research questions each can address. RECENT FINDINGS: It also reviews what network research has discovered about how network characteristics are associated with HIV and other infections, risk behaviors, preventive behaviors, and care, and discusses some ways in which network-based public health interventions have been conducted. Based on this, risk and social network research and interventions seem both feasible and valuable for addressing the many public health and social problems raised by the widespread use of opioids in the US South...
June 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29905879/health-care-utilization-for-chronic-pain-in-low-income-settings
#17
Andrea K Newman, Shweta Kapoor, Beverly E Thorn
Background: Chronic pain is a serious health problem with high rates of health care utilization (HCU). Many patients become stymied in a perpetual cycle of unsuccessful attempts to find relief from suffering through frequent health care visits. Especially within low-income populations, the burdens of health care services are especially unpleasant due to significant financial costs, barriers to transportation, and high levels of stress. This study aimed to examine factors associated with HCU for chronic pain in low-income settings...
June 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29905842/opioid-prescribing-and-polypharmacy-in-children-with-chronic-musculoskeletal-pain
#18
Sabrina Gmuca, Rui Xiao, Pamela F Weiss, David D Sherry, Andrea M Knight, Jeffrey S Gerber
Objective: Thirty percent of adults with fibromyalgia receive an opioid, but the prevalence of opioid prescribing in pediatric chronic musculoskeletal pain is unknown. The aims of this study were to determine the prevalence of and factors associated with opioid exposure and polypharmacy among children with chronic musculoskeletal pain. Methods: In this retrospective cohort study using health care claims data from 2000 to 2013, the index date was the first ICD-9 code 729...
June 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29905651/depression-in-chronic-pain-might-opioids-be-responsible
#19
Graham Mazereeuw, Mark D Sullivan, David N Juurlink
No abstract text is available yet for this article.
June 13, 2018: Pain
https://www.readbyqxmd.com/read/29905648/changes-ii-pain-intensity-following-discontinuation-of-long-term-opioid-therapy-for-chronic-non-cancer-pain
#20
Sterling McPherson, Crystal Lederhos Smith, Steven K Dobscha, Benjamin J Morasco, Michael I Demidenko, Thomas H A Meath, Travis I Lovejoy
Little is known about changes in pain intensity that may occur following discontinuation of long-term opioid therapy (LTOT). The objective of this study was to characterize pain intensity following opioid discontinuation over 12 months. This retrospective VA administrative data study identified N=551 patients nationally who discontinued LTOT. Data over 24 months (12 months prior to and following discontinuation) were abstracted from VA administrative records. Random effects regression analyses examined changes in 0-10 pain numeric rating scale scores over time, while growth mixture models delineated pain trajectory sub-groups...
June 13, 2018: Pain
keyword
keyword
24699
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"