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https://www.readbyqxmd.com/read/29332105/the-emergence-of-carbapenem-resistant-klebsiella-pneumoniae-isolates-producing-oxa-48-and-ndm-in-the-southern-asir-province-saudi-arabia
#1
Ibrahim A Al-Zahrani, Bander A Alsiri
To identify the prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) and the most common types of cabapenemases among CRKP in the Southern (Asir) province hospitals, Saudi Arabia. Methods: The cross-sectional study was conducted between late April and September in 2015. A total of 54 Klebsiella pneumoniae (K. pneumoniae) isolates with reduced sensitivity to carbapenems were obtained from various clinical specimens of the 2 largest hospitals in the Southern province. Minimum inhibitory concentrations (MICs) of carbapenems were confirmed using E-test...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29324651/incidence-microbiological-profile-and-risk-factors-of-healthcare-associated-infections-in-intensive-care-units-a-10-year-observation-in-a-provincial-hospital-in-southern-poland
#2
Małgorzata Kołpa, Marta Wałaszek, Agnieszka Gniadek, Zdzisław Wolak, Wiesław Dobroś
Healthcare-associated infections (HAIs) occurring in patients treated in an intensive care unit (ICU) are serious complications in the treatment process. Aetiological factors of these infections can have an impact on treatment effects, treatment duration and mortality. The aim of the study was to determine the prevalence and microbiological profile of HAIs in patients hospitalized in an ICU over a span of 10 years. The active surveillance method was used to detect HAIs in adult patients who spent over 48 h in a general ICU ward located in southern Poland between 2007 and 2016...
January 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29321680/cryptic-transmission-of-st405-escherichia-coli-carrying-bla-ndm-4-in-hospital
#3
Xiaoxia Zhang, Yu Feng, Weilong Zhou, Alan McNally, Zhiyong Zong
Three carbapenem-resistant Escherichia coli were recovered from rectal swabs of different patients in a tertiary hospital and were found carrying bla NDM-4, an uncommon bla NDM variant. Genome sequences of the isolates were obtained using Illumina technology and the long-read MinION sequencer. The isolates belonged to ST405 and phylogenetic group D, a globally distributed lineage associated with antimicrobial resistance. In addition to bla NDM-4, the three isolates carried 14 known resistance genes including the extended-spectrum β-lactamase gene bla CTX-M-15...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320720/simultaneous-emergence-and-rapid-spread-of-three-oxa-23-producing-acinetobacter-baumannii-st208-strains-in-intensive-care-units-confirmed-by-whole-genome-sequencing
#4
Qiong Chen, Jia-Wei Zhou, Jian-Zhong Fan, Sheng-Hai Wu, Li-Hui Xu, Yan Jiang, Zhi Ruan, Yun-Song Yu, Dao-Jun Yu, Xian-Jun Wang
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a common nosocomial bacterial pathogen with limited treatment options. CRAB outbreaks are disastrous for critically ill patients. This study investigated carbapenemase-produced A. baumannii outbreaks in a tertiary hospital. Although multiple outbreaks were suggested by pulse-field gel electrophoresis, the genetic lineages and evolution between these isolates were not clear. To investigate the genomic epidemiology of these outbreaks and to reveal possible transmission routes, whole genome sequences (WGS) were compared and analyzed...
January 8, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29319510/metallo-beta-lactamase-producing-pseudomonas-aeruginosa-in-a-healthcare-setting-in-alexandria-egypt
#5
Amani F Abaza, Soraya A El Shazly, Heba S A Selim, Gehan S A Aly
Pseudomonas aeruginosa has emerged as a major healthcare associated pathogen that creates a serious public health disaster in both developing and developed countries. In this work we aimed at studying the occurrence of metallo-beta-lactamase (MBL) producing P. aeruginosa in a healthcare setting in Alexandria, Egypt. This cross sectional study included 1583 clinical samples that were collected from patients admitted to Alexandria University Students' Hospital. P. aeruginosa isolates were identified using standard microbiological methods and were tested for their antimicrobial susceptibility patterns using single disc diffusion method according to the Clinical and Laboratory Standards Institute recommendations...
September 27, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29318906/cefiderocol-a-novel-siderophore-cephalosporin
#6
Justin J Choi, Matthew W McCarthy
The emergence of multidrug-resistant bacterial pathogens has led to a global public health emergency and novel therapeutic options and drug-delivery systems are urgently needed. Cefiderocol is a siderophore cephalosporin antibiotic that has recently been developed to combat a variety of bacterial pathogens, including β-lactam- and carbapenem-resistant organisms. Areas covered: This paper provides an overview of the mutational and plasmid-mediated mechanisms of β-lactam and carbapenem resistance, the biochemical pathways of siderophores in bacterial iron metabolism, and how cefiderocol may be able to provide better targeted antimicrobial therapy that escape these drug-resistant mechanisms...
January 10, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29316517/functional-metagenomics-reveals-a-novel-carbapenem-hydrolyzing-mobile-beta-lactamase-from-indian-river-sediments-contaminated-with-antibiotic-production-waste
#7
Nachiket P Marathe, Anders Janzon, Stathis D Kotsakis, Carl-Fredrik Flach, Mohammad Razavi, Fanny Berglund, Erik Kristiansson, D G Joakim Larsson
Evolution has provided environmental bacteria with a plethora of genes that give resistance to antibiotic compounds. Under anthropogenic selection pressures, some of these genes are believed to be recruited over time into pathogens by horizontal gene transfer. River sediment polluted with fluoroquinolones and other drugs discharged from bulk drug production in India constitute an environment with unprecedented, long-term antibiotic selection pressures. It is therefore plausible that previously unknown resistance genes have evolved and/or are promoted here...
January 6, 2018: Environment International
https://www.readbyqxmd.com/read/29313866/extensively-drug-resistant-arma-producing-acinetobacter-baumannii-in-an-italian-intensive-care-unit
#8
Carla Caio, Gaetano Maugeri, Tiziana Zingali, Floriana Gona, Stefania Stefani, Maria Lina Mezzatesta
We describe the spread of 12 carbapenem-resistant Acinetobacter baumannii isolates in hospitalized patients. All strains showed an extensively drug-resistant phenotype and high-level of aminoglycoside resistance, harboring the ArmA gene and blaoxa-23 downstream of ISAba1 (transposon Tn2008 arrangement) where both were located on the chromosome. These strains carry a class 1 integrone containing the gene cassette aacA4-catB8-aadA1. Molecular analysis revealed that all isolates belonged to the same sequence type (ST) 2 clone...
January 9, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29311072/pharmacokinetics-safety-and-tolerability-of-cefiderocol-a-novel-siderophore-cephalosporin-for-gram-negative-bacteria-in-healthy-subjects
#9
Yutaka Saisho, Takayuki Katsube, Scott White, Hiroyuki Fukase, Jingoro Shimada
Cefiderocol is a novel parenteral siderophore cephalosporin that shows potent efficacy against various Gram-negative bacteria, including carbapenem-resistant strains, in vitro and in preclinical models of infection. The aim of the present study was to evaluate the pharmacokinetics (PK), safety, and tolerability of cefiderocol after both single and multiple dosing by intravenous infusion over 60 min in healthy adult subjects. A single-ascending-dose study at doses of 100, 250, 500, 1000, and 2000 mg was conducted in 40 healthy Japanese males and females (six active and two placebo per cohort)...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29311067/molecular-epidemiology-of-emerging-blaoxa-23-like-and-blaoxa-24-like-carrying-acinetobacter-baumannii-in-taiwan
#10
Shu-Chen Kuo, Wei-Cheng Huang, Tzu-Wen Huang, Hui-Ying Wang, Jui-Fen Lai, Te-Li Chen, Tsai-Ling Lauderdale
Carbapenem-resistant Acinetobacter baumannii (CRAB) has increased significantly in recent decade in Taiwan. This study investigated the molecular epidemiology of CRAB with focus on the mechanisms of resistance and spread in isolates with blaOXA-23-like or blaOXA-24-like All 555 CRAB isolates in our 2002-2010 multi-centered collection were tested for the presence of class A, B and D carbapenemase genes. All isolates with blaOXA-23-like or blaOXA-24-like were subjected to PFGE and 82 isolates (60 blaOXA-23-like and 22 blaOXA-24-like) were selected for MLST to determine sequence type (ST) and clonal group (CG), and detection of additional β-lactamase and aminoglycoside genes...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29310949/antibiotic-resistance-rates-for-pseudomonas-aeruginosa-clinical-respiratory-and-bloodstream-isolates-among-the-veterans-affairs-healthcare-system-from-2009-to-2013
#11
Haley J Appaneal, Aisling R Caffrey, Lan Jiang, David Dosa, Leonard A Mermel, Kerry L LaPlante
Pseudomonas aeruginosa is a major cause of healthcare-associated infections and resistance among isolates is an increasing burden. The study purpose was to describe national resistance rates for clinical P. aeruginosa respiratory and bloodstream cultures and the prevalence of multidrug-resistant (MDR) P. aeruginosa within the Veterans Affairs (VA). MDR was defined as non-susceptibility to at least one drug in at least 3 of the following 5 categories: carbapenems, extended-spectrum cephalosporins, aminoglycosides, and piperacillin/tazobactam...
December 6, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29310399/blaoxa-23-like-and-blatem-rather-than-blaoxa-51-like-contributed-to-a-high-level-of-carbapenem-resistance-in-acinetobacter-baumannii-strains-from-a-teaching-hospital-in-xi-an-china
#12
Lei Han, Jine Lei, Jiru Xu, Shaoshan Han
Acinetobacter baumannii is one of the major threats in clinical infections due to its antibiotic resistance ability. It shows increasing resistance to carbapenems, mainly due to β-lactamase mediated mechanisms. The aim of this study was to investigate carbapenem resistance (CR) profiles and analyze β-lactamases genes composition of clinical A. baumannii strains from a teaching hospital in Xi'an. The resistance patterns to imipenem and meropenem were checked for 51 clinical A. baumannii strains. The existence of 15 β-lactamases genes was detected by polymerase chain reaction (PCR), and the positive genes were sequenced...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29309610/carbapenem-resistant-acinetobacter-baumannii-st294-harbouring-the-oxa-72-carbapenemase-from-a-captive-grey-parrot
#13
Peter Klotz, Lisa Jacobmeyer, Ivonne Stamm, Ursula Leidner, Yvonne Pfeifer, Torsten Semmler, Ellen Prenger-Berninghoff, Christa Ewers
No abstract text is available yet for this article.
December 21, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29307962/monotherapy-versus-combination-therapy-against-nonbacteremic-carbapenem-resistant-gram-negative-infections-a-retrospective-observational-study
#14
Abdul Ghafur, Vidyalakshmi Devarajan, T Raja, Jose Easow, M A Raja, Sankar Sreenivas, Balasubramaniam Ramakrishnan, S G Raman, Dedeepiya Devaprasad, Balaji Venkatachalam, Ramesh Nimmagadda
Background: Superiority of colistin-carbapenem combination therapy (CCCT) over colistin monotherapy (CMT) against carbapenem-resistant Gram-negative bacterial (CRGNB) infections is not conclusively proven. Aim: The aim of the current study was to analyze the effectiveness of both strategies against CRGNB nonbacteremic infections. Design: This was a retrospective observational cohort study. Subjects and Methods: Case record analysis of patients who had CRGNB nonbacteremic infections identified over a period of 4 years (January 2012-December 2015) was done by medical record review at a tertiary care center in India...
December 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29307769/molecular-epidemiology-of-carbapenem-resistant-acinetobacter-baumannii-isolates-from-a-korean-hospital-that-carry-blaoxa-23
#15
Hyejin Jeon, Shukho Kim, Mi Hyun Kim, Se Yeon Kim, Donghyuk Nam, Sung Chan Park, Sue-Hyun Park, Hanna Bae, Hyeon-Jeong Lee, Jae Hyun Cho, Won-Kil Lee, Yoo Chul Lee, Sang Hwa Lee, Min Sang Shin, Je Chul Lee
To elucidate the epidemicity of carbapenem-resistant Acinetobacter baumannii (CRAB), we investigated the antimicrobial susceptibility, the genetic basis of antimicrobial resistance, and the ability to form biofilms of 147 CRAB isolates collected between 2013 and 2015 from a Korean hospital based on sequence types (STs). Six different STs were identified: ST191 (n=47) and ST208 (n=36) were clones that had already been identified in the study hospital, whereas ST229 (n=28), ST369 (n=18), ST357 (n=17), and ST552 (n=1) were previously unknown...
January 4, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29305547/evaluation-of-the-amplidiag-carbar-vre-kit-for-the-accurate-detection-of-carbapenemase-producing-bacteria
#16
Saoussen Oueslati, Delphine Girlich, Laurent Dortet, Thierry Naas
As carbapenemase-producing Gram-negative bacilli (CP-GNB) (Enterobacteriaceae, Pseudomonadaceae and Acinetobacter spp.) are becoming a major public health issue, there is an urgent need for accurate and fast diagnostic tests. Amplidiag® Carba-R+VRE assay is a multiplex nucleic acid-based in-vitro diagnostic test intended for the detection of CP-GNB and vancomycin resistant enterococci (VRE) from cultured colonies.We have evaluated its ability to detect carbapenemases genes in 100 well-characterized GNB, and in 200 consecutive enterobacterial isolates with reduced susceptibility to carbapenems and that were referred to the French National Reference Center for carbapenem-resistance...
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29305537/triton-x-100-and-increased-volume-of-test-bacteria-in-cim-enhanced-the-detection-of-carbapenemase-producing-acinetobacter-baumannii-complex
#17
Minxue Liu, Qifei Song, Lijuan Wu, Mengjiao Li, Zhixing Chen, Mei Kang, Yi Xie
Acinetobacter baumannii complex (A. baumannii complex) has become a public health threat due to its ability to cause outbreaks of infections and acquire resistance to almost all antibiotics including carbapenem by producing carbapenemases (1, 2).….
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29303020/risk-factors-outcomes-and-genotypes-of-carbapenem-nonsusceptible-klebsiella-pneumoniae-bloodstream-infection-a-three-year-retrospective-study-in-a-large-tertiary-hospital-in-northern-china
#18
Si-Han Zheng, Sheng-Ji Cao, Hui Xu, Dan Feng, Li-Ping Wan, Guang-Jie Wang, Xiao-Guang Xiao
OBJECTIVE: To investigate the independent risk factors, outcomes and genotypes associated with carbapenem-non-susceptible K. pneumoniae bloodstream infections (BSIs) in northern China from 2014 to 2016. METHODS: Over a three-year period, a total of 289 K. pneumoniae BSI patients were identified. Medical records were extracted to obtain the clinical information. Polymerase chain reactions (PCRs) were performed to analyse the multilocus sequence typing (MLST) types, Klebsiella pneumoniae carbapenemase (KPC) and metallo-β-lactamases (MBL) genes, for replicon typing of the 10 randomly selected carbapenem-non-susceptible K...
January 5, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29301193/antibiotic-resistance-of-acinetobacter-spp-isolates-from-the-river-danube-susceptibility-stays-high
#19
Clemens Kittinger, Alexander Kirschner, Michaela Lipp, Rita Baumert, Franz Mascher, Andreas H Farnleitner, Gernot E Zarfel
Acinetobacter spp. occur naturally in many different habitats, including food, soil, and surface waters. In clinical settings, Acinetobacter poses an increasing health problem, causing infections with limited to no antibiotic therapeutic options left. The presence of human generated multidrug resistant strains is well documented but the extent to how widely they are distributed within the Acinetobacter population is unknown. In this study, Acinetobacter spp. were isolated from water samples at 14 sites of the whole course of the river Danube...
December 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29300717/notes-from-the-field-investigation-of-carbapenemase-producing-carbapenem-resistant-enterobacteriaceae-among-patients-at-a-community-hospital-kentucky-2016
#20
Sae-Rom Chae, Anna Q Yaffee, Mark K Weng, D Cal Ham, Kimberly Daniels, Amanda B Wilburn, Kimberly A Porter, Andrea H Flinchum, Sandra Boyd, Alicia Shams, Maroya S Walters, Alexander Kallen
No abstract text is available yet for this article.
January 5, 2018: MMWR. Morbidity and Mortality Weekly Report
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