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https://www.readbyqxmd.com/read/29057748/dosimetry-and-prescription-in-liver-radioembolization-with-90y-microspheres-3d-calculation-of-tumor-to-liver-ratio-from-global-99mtc-maa-spect-information
#1
Fernando Mañeru, Dolores Abós, Laura Bragado, Naiara Fuentemilla, Fernando Caudepón, Santiago Pellejero, Santiago Miquelez, Anastasio Rubio, Elena Goñi, Araceli Hernández-Vitoria
Dosimetry in liver radioembolization with <sup>90</sup>Y microspheres is a fundamental tool, both for the optimization of each treatment and for improving knowledge of the treatment effects in the tissues. Different options are available for estimating the administered activity and the tumor/organ dose, among them the so-called partition method. The key factor in the partition method is the tumor/normal tissue activity uptake ratio (T/N), which is obtained by a Single-Photon Emission Computed Tomography (SPECT) scan during a pre-treatment simulation...
October 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29057665/medications-for-substance-use-disorders-sud-emerging-approaches
#2
Eduardo R Butelman, Mary Jeanne Kreek
Substance use disorders are a group of chronic relapsing disorders of the brain, which have massive public health and societal impact. In some disorders (e.g., heroin/prescription opioid addictions) approved medications have a major long-term benefit. For other substances (e.g., cocaine, amphetamines and cannabis) there are no approved medications, and for alcohol there are approved treatments, which are not in wide usage. Approved treatments for tobacco use disorders are available, and novel medications are also under study...
October 21, 2017: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/29057158/preventing-identifying-and-treating-prescription-drug-misuse-among-active-duty-service-members
#3
Rosalie Liccardo Pacula, Sarah B Hunter, Allison J Ober, Karen Chan Osilla, Raffaele Vardavas, Janice C Blanchard, David DeVries, Emmanuel F Drabo, Kristin J Leuschner, Warren Stewart, Jennifer Walters
Prescription drug misuse (PDM) is of critical concern for the military because of its potential impact on military readiness, the health and well-being of military personnel, and associated health care costs. The purpose of this study is to summarize insights gleaned from a series of activities that the RAND Corporation undertook for the Deputy Assistant Secretary of Defense for Readiness to address this important health and military readiness issue. The authors completed a review of U.S. Department of Defense policies and a comprehensive literature review of clinical guidelines and the empirical literature on the prevention and treatment of PDM and conducted individual face-to-face interviews with 66 health and behavioral health care providers at nine medical treatment facilities across three regions within the contiguous United States to identify best practices in the prevention, identification, and treatment of PDM and the extent to which those practices are known and followed...
January 2017: Rand Health Quarterly
https://www.readbyqxmd.com/read/29057030/substance-use-in-rural-central-appalachia-current-status-and-treatment-considerations
#4
Lara Moody, Emily Satterwhite, Warren K Bickel
The burden of substance use and especially the unmatched rates of overdoses in rural Central Appalachia highlight the need for innovative approaches to curb the initiation to drug misuse and to address current substance use disorders. Effective substance use interventions involve a thorough understanding of the region. In Central Appalachia, many of the barriers to treatment are shared with other rural and impoverished areas, including a lack of access to health care and lack of health care providers with specialized training...
April 2017: Rural Mental Health
https://www.readbyqxmd.com/read/29056537/male-partner-reproductive-coercion-among-women-veterans
#5
Elian A Rosenfeld, Elizabeth Miller, Xinhua Zhao, Florentina E Sileanu, Maria K Mor, Sonya Borrero
BACKGROUND: Male partner reproductive coercion is defined as male partners' attempts to promote pregnancy through interference with women's contraceptive behaviors and reproductive decision making. Male partners may try to promote pregnancy through birth control sabotage such as taking away or destroying their partners' contraceptives, refusing to wear condoms, and/or verbally pressuring their partners to abstain from contraceptive use. Reproductive coercion is associated with an elevated risk for unintended pregnancy...
October 19, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29055881/fitbit-charge-hr-wireless-heart-rate-monitor-validation-study-conducted-under-free-living-conditions
#6
Alexander Wilhelm Gorny, Seaw Jia Liew, Chuen Seng Tan, Falk Müller-Riemenschneider
BACKGROUND: Many modern smart watches and activity trackers feature an optical sensor that estimates the wearer's heart rate. Recent studies have evaluated the performance of these consumer devices in the laboratory. OBJECTIVE: The objective of our study was to examine the accuracy and sensitivity of a common wrist-worn tracker device in measuring heart rates and detecting 1-min bouts of moderate to vigorous physical activity (MVPA) under free-living conditions...
October 20, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29055868/rescue-medications-in-epilepsy-patients-a-family-perspective
#7
Marina Gaínza-Lein, Robert Benjamin, Coral Stredny, Marlee McGurl, Kush Kapur, Tobias Loddenkemper
PURPOSE: The aim of this study was to analyze pre-hospital seizure rescue medication (RM) use in a pediatric epilepsy population, caregiver knowledge and comfort, and prescription patterns. METHOD: Cross-sectional observational study based on surveys to families of pediatric patients with epilepsy and based on medical chart review. RESULTS: One hundred (92.6%) out of 114 families answered the questionnaire. Fifty-five patients were females (55%), with a median (IQR) age of 11 (6-14) years...
October 13, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29055572/prescription-of-antibiotics-does-it-alter-the-outcome-for-patients-who-have-fractures-of-the-angle-of-the-mandible
#8
D Hammond, S Parmar, J Whitty, M McPhillips, R Wain
We retrospectively studied 708 consecutive patients at the Queen Elizabeth Hospital, Birmingham, to find out whether one of the four antibiotic protocols in use conferred any advantage (or disadvantage) on a patient who had a fractured angle of the mandible, and there was none. However, the time from initial injury until the time of the first dose of antibiotic was important. Clinically, if patients waited more than 72hours after the injury before the first dose of antibiotic was given, they had a three times higher rate of postoperative infection than patients who were given their first dose between 24 and 72hours after the injury...
October 18, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29055288/osteoinductive-effects-of-cyplexinol-in-the-management-of-osteoporosis-a-case-series
#9
Daniel Tripodi
Aims • A case study was conducted on a subject with a history of documented bone loss and the observed outcome of bone mineral density (BMD) changes when utilizing supplementation with Cyplexinol, a natural bone morphogenetic protein complex. Method and Results • A case of osteoporosis was reviewed with pertinent medical history and dual energy X-ray absorptiometry history described both pre- and postsupplementation. Results demonstrated a significant change in bone density parameter for the individual when the bone support supplement, Cyplexinol, was used...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055246/comparative-analysis-of-multiple-representative-components-in-the-herb-pair-astragali-radix-curcumae-rhizoma-and-its-single-herbs-by-uplc-qqq-ms
#10
Gang Yin, Xiaolan Cheng, Weiwei Tao, Yu Dong, Yong Bian, Wenhua Zang, Decai Tang
The herb-pair, Astragali Radix (AR) and Curcumae Rhizoma (CR), often occurs in traditional herbal prescriptions used for cancer treatment in Asian areas. In clinical application, the AR-CR herb pair was often produced by different preparation methods or with raw materials from different sources, which raised a challenge for quality control of the herb-pair medicines. In this paper, ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method (UPLC-QQQ-MS) was applied for the first time to simultaneously determine 17 main bioactive components for quality control of AR-CR herb pair...
October 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29054493/association-of-prescription-drug-monitoring-program-use-with-opioid-prescribing-and-health-outcomes-a-comparison-of-program-users-and-non-users
#11
Richard A Deyo, Sara E Hallvik, Christi Hildebran, Miguel Marino, Rachel Springer, Jessica M Irvine, Nicole O'Kane, Joshua Van Otterloo, Dagan A Wright, Gillian Leichtling, Lisa M Millet, Jody Carson, Wayne Wakeland, Dennis McCarty
Prescription drug monitoring programs (PDMPs) are a response to the prescription opioid epidemic, but their impacts on prescribing and health outcomes remain unclear, with conflicting reports. We sought to determine if prescriber use of Oregon's prescription drug monitoring program (PDMP) led to fewer high-risk opioid prescriptions or overdose events. We conducted a retrospective cohort study from October, 2011 through October, 2014, using statewide PDMP data, hospitalization registry, and vital records. Early PDMP registrants (n=927) were matched with clinicians who never registered during the study period, using baseline prescribing metrics in a propensity score...
October 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29054380/toxicity-and-efficacy-of-re-irradiation-of-high-grade-glioma-in-a-phase-i-dose-and-volume-escalation-trial
#12
Søren Møller, Per Munck Af Rosenschöld, Junia Costa, Ian Law, Hans Skovgaard Poulsen, Svend Aage Engelholm, Silke Engelholm
INTRODUCTION: The purpose of this study was to evaluate the safety and efficacy of PET and MRI guided re-irradiation of recurrent high-grade glioma (HGG) and to assess the impact of radiotherapy dose, fractionation and irradiated volume. MATERIAL AND METHODS: Patients with localized, recurrent HGG (grades III-IV) and no other treatment options were eligible for a prospective phase I trial. Gross tumor volumes for radiotherapy were defined using T1-contrast enhanced MRI and (18)F-fluoro-ethyl tyrosine PET...
October 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29054274/seventeen-year-nationwide-trends-in-antihypertensive-drug-use-in-denmark
#13
Jens Sundbøll, Kasper Adelborg, Kathryn E Mansfield, Laurie A Tomlinson, Morten Schmidt
Recent trends in use of antihypertensive drugs are unknown. From Danish nationwide prescription data, we obtained information on primary care use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, diuretics, aldosterone receptor antagonists, and calcium channel blockers. During 1999 to 2015, the use of antihypertensive drugs per 1,000 inhabitants/day increased from 184 to 379 defined daily doses (DDD), corresponding to a rise in the prevalence proportion of users from ≈20% to ≈35%...
September 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29053647/efficacy-of-different-methods-used-for-dry-socket-prevention-and-risk-factor-analysis-a-systematic-review
#14
M Taberner-Vallverdú, M-Á Sánchez-Garcés, C Gay-Escoda
BACKGROUND: Dry socket is one of the most common complications that develops after the extraction of a permanent tooth, and its prevention is more effective than its treatment. OBJECTIVES: Analyze the efficacy of different methods used in preventing dry socket in order to decrease its incidence after tooth extraction. MATERIAL AND METHODS: A Cochrane and PubMed-MEDLINE database search was conducted with the search terms "dry socket", "prevention", "risk factors", "alveolar osteitis" and "fibrynolitic alveolitis", both individually and using the Boolean operator "AND"...
October 20, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29052816/depressive-symptoms-predict-anti-tumor-necrosis-factor-therapy-noncompliance-in-patients-with-inflammatory-bowel-disease
#15
Alexis Calloway, Robin Dalal, Dawn B Beaulieu, Caroline Duley, Kimberly Annis, Lawrence Gaines, Chris Slaughter, David A Schwartz, Sara Horst
BACKGROUND: Noncompliance in use of anti-tumor necrosis factor (anti-TNF) therapy in patients with moderate-to-severe inflammatory bowel disease (IBD) can be a factor in medication failure. Few studies have evaluated the contribution of depressive symptoms to medication noncompliance in anti-TNF therapies. METHODS: A retrospective chart review was performed in a single-center tertiary care IBD center for patients with Crohn's disease and ulcerative colitis starting anti-TNF therapy over a 2-year period...
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29052741/-regional-differences-of-adhd-diagnosis-rates-in-health-insurance-data-from-2005-to-2015-methodological-considerations-and-results
#16
REVIEW
Thomas G Grobe
BACKGROUND AND OBJECTIVES: Attention deficit hyperactivity disorders (ADHD) are among the most common mental disorders in children and adolescents. For a number of years there has been evidence of regional differences in Germany. This article provides current results on the frequency of diagnosis and treatment and also discusses methodological aspects. MATERIALS AND METHODS: The analysis is based on routine data of a statutory health insurance company including annual diagnoses and drug prescriptions from 2005 to 2015 of at least 1...
October 20, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29052693/medicare-formulary-coverage-restrictions-for-prescription-opioids-2006-to-2015
#17
Elizabeth A Samuels, Joseph S Ross, Sanket S Dhruva
No abstract text is available yet for this article.
October 10, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29052257/utility-of-reproductive-life-plans-in-identification-of-potentially-teratogenic-medication-use-a-pilot-study
#18
Natalie DiPietro Mager, Caitlin Mills, April Snelling
BACKGROUND: Teratogenic medications increase risks of miscarriage, fetal death, and/or birth defects. It is important to identify whether women of childbearing potential are taking these medications and to minimize exposure to these agents through change in drug therapy before conception and/or use of effective contraception to prevent conception. OBJECTIVE: To determine the utility of reproductive life plans as tools to identify women using potentially teratogenic medications...
October 20, 2017: Birth
https://www.readbyqxmd.com/read/29052109/assessments-of-opportunities-to-improve-antibiotic-prescribing-in-an-emergency-department-a-period-prevalence-survey
#19
Tristan T Timbrook, Aisling R Caffrey, Anais Ovalle, Maya Beganovic, William Curioso, Melissa Gaitanis, Kerry L LaPlante
INTRODUCTION: Approximately 30% of all outpatient antimicrobials are inappropriately prescribed. Currently, antimicrobial prescribing patterns in emergency departments (ED) are not well described. Determining inappropriate antimicrobial prescribing patterns and opportunities for interventions by antimicrobial stewardship programs (ASP) are needed. METHODS: A retrospective chart review was performed among a random sample of non-admitted, adult patients who received an antimicrobial prescription in the ED from January 1 to December 31, 2015...
October 19, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29052092/a-72-h-intervention-for-improvement-of-the-rate-of-optimal-antibiotic-therapy-in-patients-with-bloodstream-infections
#20
R Murri, F Taccari, T Spanu, T D'Inzeo, I Mastrorosa, F Giovannenze, G Scoppettuolo, G Ventura, C Palazzolo, M Camici, S Lardo, B Fiori, M Sanguinetti, R Cauda, M Fantoni
Antimicrobial stewardship programs are implemented to optimize the use of antibiotics and control the spread of antibiotic resistance. Many antimicrobial stewardship interventions have demonstrated significant efficacy in reducing unnecessary prescriptions of antibiotics, the duration of antimicrobial therapy, and mortality. We evaluated the benefits of a combination of rapid diagnostic tests and an active re-evaluation of antibiotic therapy 72 h after the onset of bloodstream infection (BSI). All patients with BSI from November 2015 to November 2016 in a 1100-bed university hospital in Rome, where an Infectious Disease Consultancy Unit (Unità di Consulenza Infettivologica, UDCI) is available, were re-evaluated at the bedside 72 h after starting antimicrobial therapy and compared to two pre-intervention periods: the UDCI was called by the ward physician for patients with BSI and the UDCI was called directly by the microbiologist immediately after a pathogen was isolated from blood cultures...
October 19, 2017: European Journal of Clinical Microbiology & Infectious Diseases
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