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https://www.readbyqxmd.com/read/29236221/dpp-4-inhibitor-induced-rheumatoid-arthritis-among-diabetics-a-nested-case-control-study
#1
Niranjan Kathe, Anuj Shah, Qayyim Said, Jacob T Painter
INTRODUCTION: The risk of rheumatoid arthritis (RA) associated with dipeptidyl peptidase-4 inhibitor (DPP-4i) use is unclear. This study assesses the RA risk associated with DPP-4i use among a diabetic cohort initiating second-line therapy. METHODS: This was a nested case-control study, using the adult diabetic population starting second-line antidiabetic therapy from IMS LifeLink Plus® database (2006-2015). Cases were those with two or more RA diagnosis, at least one prescription, and 180 days enrollment prior to the event date (earliest of the two: first RA diagnosis, first RA prescription)...
December 13, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29235900/treatment-and-discharge-patterns-among-patients-hospitalized-with-non-valvular-atrial-fibrillation-transitioning-from-the-inpatient-to-outpatient-setting
#2
Henry J Henk, Feng Cao, Kenneth Tuell, Kwanza Price, Prianka Singh, Jack Mardekian, Kevin Odell, Chad Patel, Wilson Tan, George H Sands, Shalabh Singhal, Jeffrey Trocio, Lien Vo
OBJECTIVE: To evaluate inpatient oral anticoagulant (OAC) treatment, discharge location, and post-discharge OAC treatment for patients hospitalized with non-valvular atrial fibrillation (NVAF). RESEARCH DESIGN AND METHODS: Retrospective study using claims data linked to hospital electronic health records (EHR). Patients (N = 2,484) were hospitalized with a primary (38%) or secondary (62%) diagnosis of AF without evidence of mitral valvular heart disease or valve replacement between January 2009 and September 2013...
December 13, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29235430/prevalence-and-risk-factors-for-delirium-diagnosis-in-patients-followed-in-general-practices-in-germany
#3
Jens Bohlken, Karel Kostev
BACKGROUND: The aim of this study is to identify the prevalence and risk factors of documented delirium in general practices in Germany. METHODS: The present study includes 2,194 patients over the age of 65 years with delirium and 2,194 controls without delirium from a sample of 6,180,042 patients from 1,262 general practices. Multivariate logistic regression models were fitted with delirium as a dependent variable and other disorders and drugs as potential predictors...
December 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29235398/antipsychotic-treatment-of-community-dwelling-and-institutionalised-patients-with-dementia-in-germany
#4
Philipp Hessmann, Richard Dodel, Erika Baum, Matthias J Müller, Greta Paschke, Bernhard Kis, Jan Zeidler, Mike Klora, Jens-Peter Reese, Monika Balzer-Geldsetzer
OBJECTIVE: A restrictive use of antipsychotic drugs in patients with Alzheimer's disease (AD) is recommended due to an increased risk of cerebrovascular events and mortality. We hypothesise that the prescription of antipsychotics is associated with the patients' socio-demographic and clinical status (e.g., dementia severity). METHODS: The prescription of antipsychotics was cross-sectionally evaluated in 272 community-dwelling and 123 institutionalised patients with AD across all severity stages of dementia...
December 13, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29235299/-prescription-regularity-of-famous-veteran-traditional-chinese-medicine-doctor-yu-guoyou-for-treating-gastrointestinal-failure-based-ondata-mining
#5
Qing Wang, Yi-Lian Chen, Guo-Lin Wu, Fu-Lin Xiong, Guo-You Yu
Gastrointestinal failure is a kind of severe systemic inflammatory response, and often complicated with multiple organ dysfunction syndrome. Integrated traditional Chinese and Western medicine have a better curative effect in treating it. This study collected the famous veteran TCM physician Yu Guoyou's 175 prescriptions for treating 89 cases of gastrointestinal failure, calculated the frequency of traditional Chinese medicines and their categories, and analyzed the medication regularity with system clustering method, so as to summarize Yu's frequently used drugs and prescriptions...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29235298/-effect-of-saposhnikoviae-radix-on-pharmacokinetics-and-tissue-distributions-of-active-components-in-tongxie-yaofang-in-rats
#6
Rui-Feng Liang, Wen-Jing Ge, Zheng Wei, Xue-Xia Zhang, Wei-Feng Cui, Xue Liu, Geng-Sheng Li
Tongxie Yaofang (TXYF) is a famous formula that has been used for treating gastrointestinal diseases in traditional Chinese medicine(TCM). Saposhnikoviae Radix is considered as a meridian guiding drug in TXYF and could enhance the effectiveness of prescription. However, the scientific evidence for this effect is still not clear. To reveal the interactions of Saposhnikoviae Radix with other herbs, we conducted this study on the pharmacokinetic profile and tissue distribution of active ingredients of TXYF in rats...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29234842/-patients-with-a-wearable-cardioverter-defibrillator-wcd-prescription-function-and-rehabilitation-support
#7
REVIEW
A Schlitt, M Guha, M Noutsias, H H Klein, H U Klein
Assessment of a permanent risk of life-threatening ventricular arrhythmia in patients with severely reduced left ventricular ejection fraction (LVEF <35%), e. g. after myocarditis, dilated cardiomyopathy, acute myocardial infarction, in patients with postpartum cardiomyopathy or implantable cardioverter-defibrillator (ICD) and cardiac resynchronization treatment plus defibrillator (CRT-D) infection with temporary explantation of the system is a medical challenge. This is time-consuming and unsafe because life-threatening ventricular arrhythmias may occur during the time of risk assessment...
December 12, 2017: Herz
https://www.readbyqxmd.com/read/29234542/demographics-and-sexual-characteristics-of-sex-enhancing-medication-users-study-of-a-web-based-cross-sectional-sample-of-sexually-active-men
#8
Abul-Fotouh Ahmed, Saad Alshahrani, Anthony Morgan, Ahmed H Gabr, Mohamed Abdel-Razik, Abdallah Daoud
Objectives: To evaluate the frequency of sex-enhancing medications (S-EM) use and to investigate the demographics and sexual characteristics of the S-EM users amongst a Saudi Arabian male population. Subjects and methods: A cross-sectional sample of 1176 Saudi Arabian men was recruited using a web-based survey between 1 January and 1 April 2015. The survey included multiple open and closed questions to assess the frequency of S-EM use; and demographics, clinical, and sexual characteristics of S-EM users, as well as their perceptions of S-EM...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29234434/prescription-function-prediction-using-topic-model-and-multilabel-classifiers
#9
Lidong Wang, Yin Zhang, Yun Zhang, Xiaodong Xu, Shihua Cao
Determining a prescription's function is one of the challenging problems in Traditional Chinese Medicine (TCM). In past decades, TCM has been widely researched through various methods in computer science, but none concentrates on the prediction method for a new prescription's function. In this study, two methods are presented concerning this issue. The first method is based on a novel supervised topic model named Label-Prescription-Herb (LPH), which incorporates herb-herb compatibility rules into learning process...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234432/ethanol-extract-of-root-of-prunus-persica-inhibited-the-growth-of-liver-cancer-cell-hepg2-by-inducing-cell-cycle-arrest-and-migration-suppression
#10
Hongchun Shen, Honglian Wang, Li Wang, Lu Wang, Menglian Zhu, Yao Ming, Sha Zhao, Junming Fan, En Yin Lai
Liver cancer is the second most lethal cancer and hepatocellular carcinoma (HCC) is the primary cancer subgroup. However, the current chemotherapy agents remain ineffective and present wide side effects for advanced HCC patient. In this study, we investigated the antitumor role of ethanol extract of root of peach tree (Prunus persica (L.) Batsch and hereafter designated as TSG in short of its Chinese name), which is an important ingredient in Chinese medicine prescription, in liver cancer cell HepG2. By cell viability assay, we showed that addition of TSG in the culture medium inhibited the cell growth of HepG2 cells in a dose and time-dependent way...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234429/effects-of-jiawei-shaoyao-gancao-decoction-and-its-drug-containing-serum-on-proliferation-apoptosis-and-ultrastructure-of-human-adenomyosis-foci-cells
#11
Yu-Yan Zeng, Kun-Yin Li
Objective: The present study aimed to investigate the effects of Jiawei Shaoyao-Gancao Decoction (JSGD) and its drug-containing serum (CDS) on the proliferation, apoptosis, and ultrastructure of human adenomyosis foci cells. Methods: Primary cultures of human adenomyosis foci cells were prepared from hard uterine lesions of adenomyosis patients. The cells were treated with JSGD (10 and 20 mg/ml), CDS, and mifepristone (MIF) for 24 or 48 h. Cell proliferation was detected using CCK-8 assay, cell apoptosis was measured by flow cytometry, and the cell ultrastructure was observed by transmission electron microscopy (TEM)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234393/reduced-mlh3-expression-in-the-syndrome-of-gan-shen-yin-deficiency-in-patients-with-different-diseases
#12
Juan Du, Maofeng Zhong, Dong Liu, Shufang Liang, Xiaolin Liu, Binbin Cheng, Yani Zhang, Zifei Yin, Yuan Wang, Changquan Ling
Traditional Chinese medicine formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess the characteristic genes of gan-shen Yin deficiency constitution in different diseases. Fifty primary liver cancer (PLC) patients, 94 hypertension (HBP) patients, and 100 diabetes mellitus (DM) patients were enrolled and classified into gan-shen Yin deficiency group and non-gan-shen Yin deficiency group according to the body constitution questionnaire to assess the clinical manifestation of patients...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234380/compression-of-the-fourth-ventricle-using-a-craniosacral-osteopathic-technique-a-systematic-review-of-the-clinical-evidence
#13
REVIEW
Anna Żurowska, Roksana Malak, Anna Kołcz-Trzęsicka, Włodzimierz Samborski, Małgorzata Paprocka-Borowicz
Compression of the fourth ventricle (CV4) is a well-known osteopathic procedure, utilized by osteopaths, osteopathic physicians, craniosacral therapists, physical therapists, and manual therapists as part of their healthcare practice based on some evidence suggesting impact on nervous system functions. The main objective of the study was to identify randomized controlled trials (RCTs) assessing the clinical benefits of CV4 and to show the evidence supporting clinical prescriptions, guides, and advice in treating...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234355/treatment-of-community-acquired-pneumonia-are-all-countries-treating-children-in-the-same-way-a-literature-review
#14
REVIEW
Daniele Donà, Dora Luise, Liviana Da Dalt, Carlo Giaquinto
Background: Pneumonia represents an important threat to children's health in both developed and developing countries. In the last 10 years, many national and international guidelines on the treatment of pediatric CAP have been published, in order to optimize the prescription of antibiotics and limit their cost and side effects. However, the practical implementation of these guidelines is still limited. Main Text: We analyzed the current recommendations for the therapy of pediatric community-acquired pneumonia (CAP) that all converge on the identification of aminopenicillins and beta-lactams as the optimal treatment for CAP...
2017: International Journal of Pediatrics
https://www.readbyqxmd.com/read/29233851/incremental-shuttle-walk-test-to-assess-and-prescribe-exercise-for-subjects-with-bronchiectasis-hallway-versus-treadmill
#15
Cristiane S Oliveira, Anderson José, Crislaine O Santos, Cristiane H Y de Oliveira, Thiago C O Carvalho, Rejane A S de Castro, Jessyca P R Selman, Anderson A de Camargo, Simone Dal Corso
INTRODUCTION: The incremental shuttle walk test was initially developed to be carried out in a hallway (ISWT-H) but has been modified to be performed on a treadmill (ISWT-T). However, it is still unknown whether performance on ISWT-H and ISWT-T are similar in patients with bronchiectasis. In this study, we compared the performance, physiological responses, and perception of effort between the ISWT-T with a handrail and ISWT-H for subjects with bronchiectasis. We also sought to estimate and compare the prescription for training intensity with both tests...
December 12, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29233498/proton-pump-inhibitors-and-cardiovascular-events-a-systematic-review
#16
REVIEW
Timothy P Shiraev, Andrew Bullen
BACKGROUND: Proton pump inhibitors (PPIs) are a commonly prescribed medication that recent data has linked to an increased risk of cardiovascular morbidity and all cause morbidity. The current study sought to perform a systematic review to investigate the link between PPIs and morbidity and mortality METHODS: A systematic review was carried out as per the PRISMA guidelines, with information databases including Pubmed, Medline, and the Cochrane Review Database. English-language studies of all types published from January 1990 to October 2016 were considered...
November 20, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29233441/professional-and-pre-professional-pharmacy-students-perceptions-of-team-based-learning-tbl-at-a-private-research-intensive-university
#17
Danielle M Miller, Karen Khalil, Olivia Iskaros, Jenny A Van Amburgh
BACKGROUND AND PURPOSE: Pharmacy students need to develop critical thinking and problem-solving skills as well as be a valuable team member. The use of team based learning (TBL) fosters effective team collaboration, enables continuous active and self-directed learning, and requires both individual and team accountability. The purpose was to evaluate pharmacy students' perceptions and experiences related to TBL in different years of the pharmacy curriculum. EDUCATIONAL ACTIVITY AND SETTING: Two classes, Introduction to the Profession of Pharmacy (intro), a required course, and Self-Care/Non-Prescription Medications (self-care), an elective course, utilize the TBL approach...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233414/teaching-drug-utilization-review-skills-via-a-simulated-clinical-decision-making-exercise
#18
Cortney M Mospan, Katelyn M Alexander
BACKGROUND: Drug utilization review (DUR) is a central role of the pharmacist, especially within the community pharmacy setting. Previous literature has shown risk of "alert fatigue", supporting the necessity of pharmacists to utilize a step-wise approach in evaluation of drug therapy during the verification process. Many students are intimidated by this process, and may lack verification practice or experience until their first day as a licensed pharmacist. EDUCATIONAL ACTIVITY AND SETTING: An innovative skills-based laboratory exercise was developed for third-year pharmacy students to develop DUR skills...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233397/assessment-of-student-pharmacists-ethical-decision-making
#19
Jaclyn R Myers, Mary E Kiersma, Kimberly S Plake
INTRODUCTION: In previous research, investigators have expressed concern about the ethical ambivalence of pharmacists in decision-making. The objectives of this study were to examine student pharmacists': 1) attitudes and responses regarding specific common ethical situations and 2) perceived level of difficulty in making ethical decisions. METHODS: A self-administered 38-item survey was given to second and third year student pharmacists at Purdue University. The survey comprised five sections, including: 1) attitudes towards common ethical situations, 2) responses to specific ethical scenarios, 3) emergency lending, 4) perceived level of difficulty in resolving ethical dilemmas, and 5) demographics...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233368/faculty-perception-of-team-based-learning-over-multiple-semesters
#20
Clark D Kebodeaux, Golden L Peters, Paul M Stranges, Jamie L Woodyard, Scott Martin Vouri
INTRODUCTION: Perspectives from faculty regarding team-based learning (TBL) are not well understood. Previous studies describe faculty preference for TBL due to increased student interaction despite requiring increased time for design. The perception of changes in faculty workload over multiple semesters has not been measured. This research evaluates faculty workload and perceived student engagement after implementing TBL in a required non-prescription medication course over multiple semesters...
November 2017: Currents in Pharmacy Teaching & Learning
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