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Conjunctival lymphoma

J J Huang, B Li, Q F Liang, X L Xu, F Gao, Z B Zhang
Objective: We aimed to identify and describe the clinical and histopathologic characteristics of conjunctival neoplasms. Methods: Retrospective case series study. We collected and analyzed the clinical and histopathologic data of the conjunctival neoplastic specimens including the age, gender, and histopathologic diagnosis of all patients obtained from Beijing Tongren Eye Center between October 2003 and October 2015. All the pathology diagnosis results were divided into two categories which were benign and malignant tumors, according to Shields histopathological classification methods and the pathology diagnosis results in our department...
October 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Carol L Shields, Adel E Alset, Nina S Boal, Mairghread G Casey, Austen N Knapp, Jordan A Sugarman, Marisa A Schoen, Phillip S Gordon, Alexzandra M Douglass, Kareem Sioufi, Emil A T Say, Jerry A Shields
PURPOSE: To evaluate frequency of conjunctival tumors in all ages and compare benign versus (vs) malignant counterparts. DESIGN: Retrospective series. METHODS: Setting: Tertiary referral center STUDY POPULATION: 5002 patients OBSERVATION: Clinical features MAIN OUTCOME MEASURE: Differentiation benign from malignant counterparts RESULTS: The tumor was benign (52%), premalignant (18%), or malignant (30%). Malignant tumors included melanoma (12%), squamous cell carcinoma (9%), lymphoma (7%), and others...
October 7, 2016: American Journal of Ophthalmology
Karen L Christopher, Victor M Elner, Hakan Demirci
The authors describe a 39-year-old woman treated with fingolimod for relapsing-remitting multiple sclerosis for 2 years who then developed a bilateral conjunctival mucosa-associated lymphoid tissue lymphoma. Fingolimod treatment for multiple sclerosis has been associated with lymphoma in 3 previously reported cases. This is the first case of ocular adnexal lymphoma presumed to be due to fingolimod. Given that ophthalmologists regularly monitor many patients on fingolimod for fingolimod-associated macular edema and ophthalmic manifestations of multiple sclerosis, the authors hope to alert physicians of the possibility of ocular adnexal lymphoma in these patients...
August 16, 2016: Ophthalmic Plastic and Reconstructive Surgery
Nicholas Cook, Fizza Mushtaq, Christina Leitner, Andrew Ilchyshyn, George T Smith, Ian A Cree
BACKGROUND: Toxicity is rarely considered in the differential diagnosis of conjunctivitis, but we present here a new form of toxic conjunctivitis with unusual clinical features. Between 2010 and 2013, a new clinical presentation of chronic conjunctivitis unresponsive to normal treatment was noted within a Primary Care Ophthalmology Service. METHODS: Retrospective review of case records and histopathology results. RESULTS: A total of 55 adult patients, all females, presented with epiphora and stickiness...
2016: BMC Ophthalmology
Chung-Yu Hsieh, Yi-Ping Liao, Chia-Che Wu, Sheng-Po Yuan, Jennifer Hui-Chun Ho, Rachel Roan, Phui-Ly Liew, Ming-Tang Lai, Feipeng Lee
The aim of the present study was to report a rare case of single-clone, immunoglobulin heavy chain (IgH)-rearranged mucosa-associated lymphoid tissue (MALT) lymphoma in the conjunctiva, with nasal cavity dissemination through the nasolacrimal duct. A 24-year-old female was diagnosed with MALT lymphoma of the nasal cavity at the Department of Otolaryngology, Wan Fang Medical Center, Taipei Medical University (Tapei, Taiwan) in October 2008. A biopsy of the relapsing conjunctival lesion revealed a MALT lymphoma by pathological staining, while a single-clone, IgH-rearranged tumor lesion in the nasal cavity and conjunctiva was confirmed using continuous sinus computed tomography scans and polymerase chain reaction...
August 2016: Oncology Letters
R H Parada-Vásquez, V E Lomas-Guaman, C R León-Roldán
CASE REPORT: A 43-year-old woman presented with a salmon-coloured patch of 0.7mm diameter in the right eye that extended into the lower fornix in the bulbar and tarsal conjunctiva, with irregular edges, and highly vascularised. Incisional biopsy was performed, showing it to be a low-grade conjunctival non-Hodgkin B cell lymphoma (or a mucosa associated lymphoid tissue [MALT] lymphoma). DISCUSSION: The lesion remained stable for 24 months of follow-up, when a relapse of the condition occurred, producing an enlargement of the initial lesion...
July 4, 2016: Archivos de la Sociedad Española de Oftalmología
Hayyam Kiratli, Salih Uzun, Ali Varan, Canan Akyüz, Diclehan Orhan
Inflammatory myofibroblastic tumor (IMT) is a distinct mesenchymal neoplasm of myofibroblastic spindle cells associated with an inflammatory infiltrate formed by lymphocytes, eosinophils, and plasma cells in a myxoid or collagenous stroma. This tumor has a predilection for children and young adults and most commonly occurs in the lungs, retroperitoneum, abdomen, and pelvis. Ocular and orbital involvement is exceedingly rare. We describe a case of IMT in a 7-year-old girl involving the cornea, conjunctiva, and the anterior orbit treated with crizotinib, resulting in complete tumor remission...
June 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Kwang Meng Cham, Helen Riad
No abstract text is available yet for this article.
May 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
S Cotting-Bodmer, A Moulin, C P Herbort, N Ketterer, M Betz, A Pica, A Schalenbourg
No abstract text is available yet for this article.
April 2016: Klinische Monatsblätter Für Augenheilkunde
Shuchi Gulati, Zélia M Corrêa, Nagla Karim, Stephen Medlin
CONTEXT: Elderly patients with visual loss often have age-related macular degeneration, diabetic retinopathy, glaucoma, and cataract as common causes of visual loss. Other less common etiologies should be considered, especially in those presenting with systemic associations. CASE REPORT: The patient discussed in our review is an 80-year-old female, with a history of diabetic retinopathy and macular degeneration who presented with a sudden deterioration of vision...
January 2016: North American Journal of Medical Sciences
Sultan S Aldrees, Pablo Zoroquiain, Sarah A Alghamdi, Patrick T Logan, Sonia Callejo, Miguel N Burnier
Background. Ocular involvement in mycosis fungoides (MF) cases occurs in one-third of patients with the eyelid being the most frequent site affected; however, conjunctival involvement is rarely reported. Herein, we report a rare case of conjunctival involvement of MF. Case Presentation. A 66-year-old man who was previously diagnosed with MF in 2010 and was treated presented in 2014 complaining of foreign body sensation and redness in both eyes. Slit lamp examination of both eyes showed erythematous conjunctival growth that extended circumferentially...
2016: Case Reports in Ophthalmological Medicine
Michael S Binkley, Susan M Hiniker, Sarah S Donaldson, Richard T Hoppe
PURPOSE: Primary radiation therapy (RT) achieves excellent local control and overall survival when treating localized orbital lymphoma. However, evidence supporting irradiation of partial orbit volumes to spare nearby critical structures is lacking. We sought to investigate outcomes for patients with localized orbital lymphoma treated with partial orbit irradiation. METHODS AND MATERIALS: We retrospectively reviewed patients with orbital lymphoma treated with RT at our institution who met our inclusion criteria: biopsy-confirmed, low-grade lymphoma, localized disease, partial orbit treatment volumes, and follow-up >3months...
July 2016: Practical Radiation Oncology
Marina M Kirkegaard, Peter K Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Santosh G Honavar, Jwu J Khong, Penny A McKelvie, Kaustubh Mulay, Jan U Prause, Elisabeth Ralfkiaer, Lene D Sjö, Peter B Toft, Geeta K Vemuganti, Bradley A Thuro, Jeremy Curtin, Steffen Heegaard
IMPORTANCE: To date, the clinical features of the various subtypes of conjunctival lymphoma (CL) have not been previously evaluated in a large cohort. OBJECTIVE: To characterize subtype-specific clinical features of CL and their effect on patient outcome. DESIGN, SETTING, AND PARTICIPANTS: A retrospective multicenter study was performed. Patient data were collected from January 1, 1980, through December 31, 2010. The dates of the analysis were May 15, 2015, to August 20, 2015...
April 2016: JAMA Ophthalmology
Szu-Ying Tsai, Yu-Chien Shiau, Shan-Ying Wang, Yen-Wen Wu
Herein we present the F-FDG PET/CT findings in conjunctival melanoma as a second primary cancer in a 56-year-old Taiwanese man with a history of small lymphocytic lymphoma/chronic lymphocytic leukemia and nasal cavity carcinoma under remission. The right eye lesion slowly progressed since noted by the patient himself 2 years ago, but he refused biopsy and further treatment including surgery. Either small lymphocytic lymphoma/chronic lymphocytic leukemia or conjunctival melanoma is extremely rare in Asians, left alone in combination with a third malignancy of nasal cavity carcinoma...
March 2016: Clinical Nuclear Medicine
H Höh, S Armbrust, T Decker, U Holland, S Balschat
MEDICAL HISTORY: In February 2007, a 13-year old boy presented with a livid tumour in the lower conjunctival fornix of the left eye. OPHTHALMOLOGICAL FINDINGS: The tumor was salmon-coloured, bulging and elastic and filled the whole lower conjunctival fornix of the left eye. There was no other pathological finding in the left eye. Uncorrected visual acuity was 20/20. Intraocular pressure was 12 mmHg. The eye was fully motile. TREATMENT: Incisional biopsy was performed in February 2007...
January 2016: Klinische Monatsblätter Für Augenheilkunde
Joshua Duncan, Yingxin Chen, Deborah Fuchs, Carlos Cantu, Mingwu Wang
PURPOSE: Conjunctival lymphoma rarely can have atypical clinical presentations. The authors report a case of conjunctival follicular lymphoma that presented solely as bilateral chronic follicular conjunctivitis. This case underscores that the pathological characteristics of conjunctival follicles can only be determined by histopathologic examination. METHODS: The patient underwent conjunctival scraping and biopsy after clinical history and examination failed to reveal the etiology of his chronic, symptomatic, follicular conjunctivitis...
March 2016: Cornea
S Labrador Velandia, E García Lagarto, M A Saornil, C García Álvarez, R Cuello, P Diezhandino
CLINICAL CASE: The case is presented of a 43 year-old male patient with chronic follicular conjunctivitis, negative bacterial serology, and refractory to local treatment. The incisional biopsy performed showed to be consistent with reactive lymphoid hyperplasia. A year later, a new incisional biopsy showed follicular lymphoma, with no systemic involvement, and he was treated with local radiotherapy. DISCUSSION: When a chronic follicular conjunctivitis is refractory to treatment, it is essential to perform an incisional biopsy to establish the histopathological diagnosis that can range from chronic inflammation, reactive lymphoid hyperplasia to lymphoma...
February 2016: Archivos de la Sociedad Española de Oftalmología
P L Müller, K U Loeffler, F G Holz, H-P Fischer, M C Herwig
An 82-year-old male patient presented with a salmon-pink colored conjunctival tumor of the left eye. A circumscribed, dense and whitish portion was detected by clinical examination. The histophological and immunhistochemical examination of the biopsy tissue revealed a CD20+ marginal zone lymphoma of the conjunctiva with amyloid deposits. Extranodal marginal zone lymphoma at this site is the most common lymphoma of the ocular adnexa and accounts for 5-10% of malignant diseases. An association with amyloid production is very rare and according to the current state of knowledge has no known impact on the outcome...
July 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Hiroki Takahashi, Yoshihiko Usui, Shunichiro Ueda, Naoyuki Yamakawa, Aiko Sato-Otsubo, Yusuke Sato, Seishi Ogawa, Hiroshi Goto
PURPOSE: We identified the genomic signature of ocular adnexal lymphoproliferative disorders (LPDs), especially ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma, IgG4-related ophthalmic disease (IgG4-ROD), reactive lymphoid hyperplasia (RLH), and diffuse large B-cell lymphoma (DLBCL). METHODS: We included 52 subjects with ocular adnexal LPDs (13 orbital MALT lymphomas, 16 conjunctival MALT lymphomas, 13 IgG4-RODs, 4 RLHs, and 6 DLBCLs) who had been treated at the Tokyo Medical University Hospital from 2008 to 2012...
June 2015: Investigative Ophthalmology & Visual Science
Min Joung Lee, Namju Kim, Ji-Young Choe, Sang In Khwarg, Yoon Kyung Jeon, Ho-Kyung Choung, Ji Eun Kim
This study aims to analyze clinical and pathological characteristics of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) accompanying IgG4-positive cells. Fifty patients with a diagnosis of primary non-conjunctival ocular adnexal EMZL were enrolled in this study. The number of IgG4-positive cells and the ratio of IgG/IgG4 were evaluated by immunohistochemistry in the biopsy specimens. The patients were divided into two groups based on the absolute number and the ratio of IgG4-positive cells (IgG4-posivite vs IgG4-negative groups)...
2015: PloS One
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