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Sugammadex

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https://www.readbyqxmd.com/read/28811009/the-feasibility-of-sugammadex-for-general-anesthesia-and-facial-nerve-monitoring-in-patients-undergoing-parotid-surgery
#1
I-Cheng Lu, Pi-Ying Chang, Miao-Pei Su, Po-Nien Chen, Hsiu-Ya Chen, Feng-Yu Chiang, Che-Wei Wu
The use of neuromuscular blocking agent (NMBA) during anesthesia may interfere with facial nerve monitoring (FNM) during parotid surgery. Sugammadex has been reported to be an effective and safe reversal of rocuronium-induced neuromuscular block (NMB) during surgery. This study investigated the feasibility and clinical effectiveness of sugammadex for NMB reversal during FNM in Parotid surgery. Fifty patients undergoing parotid surgery were randomized allocated into conventional anesthesia group (Group C, n = 25) and sugammadex group (Group S, n = 25)...
August 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28806470/efficacy-and-safety-of-sugammadex-versus-neostigmine-in-reversing-neuromuscular-blockade-in-adults
#2
REVIEW
Ana-Marija Hristovska, Patricia Duch, Mikkel Allingstrup, Arash Afshari
BACKGROUND: Acetylcholinesterase inhibitors, such as neostigmine, have traditionally been used for reversal of non-depolarizing neuromuscular blocking agents. However, these drugs have significant limitations, such as indirect mechanisms of reversal, limited and unpredictable efficacy, and undesirable autonomic responses. Sugammadex is a selective relaxant-binding agent specifically developed for rapid reversal of non-depolarizing neuromuscular blockade induced by rocuronium. Its potential clinical benefits include fast and predictable reversal of any degree of block, increased patient safety, reduced incidence of residual block on recovery, and more efficient use of healthcare resources...
August 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28802619/sugammadex-efficacy-for-reversal-of-rocuronium-and-vecuronium-induced-neuromuscular-blockade-a-pooled-analysis-of-26-studies
#3
William Joseph Herring, Tiffany Woo, Christopher A Assaid, Robert J Lupinacci, Hendrikus J Lemmens, Manfred Blobner, Karin S Khuenl-Brady
STUDY OBJECTIVE: To summarize and compare efficacy of sugammadex with neostigmine or placebo for reversal of rocuronium- or vecuronium-induced neuromuscular blockade (NMB), and to demonstrate consistency of sugammadex results across various patient populations. DESIGN: Pooled analysis on data from 26 multicenter, randomized, Phase II and III studies. SETTING: Operating room. PATIENTS: 1855 adults undergoing surgery under general anesthesia and receiving rocuronium or vecuronium for NMB...
September 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28794837/use-of-sugammadex-in-lung-cancer-patients-undergoing-video-assisted-thoracoscopic-lobectomy
#4
Hyun Chul Cho, Jong Hwan Lee, Seung Cheol Lee, Sang Yoong Park, Jong Cheol Rim, So Ron Choi
BACKGROUND: This study aimed to retrospectively evaluate the use of sugammadex in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy. METHODS: Data were obtained from medical record review of patients who underwent VATS lobectomy from January 2013 to November 2014. Fifty patients were divided into two groups: the sugammadex group (group S, n = 19) was administered sugammadex 2 mg/kg, while the pyridostigmine group (group P, n = 31) received pyridostigmine 20 mg with glycopyrrolate 0...
August 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28794831/use-of-sugammadex-in-clinical-practice
#5
EDITORIAL
Hee-Pyoung Park
No abstract text is available yet for this article.
August 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28757832/sugammadex-versus-two-doses-of-neostigmine-for-reversal-of-rocuronium-in-gastric-sleeve-surgery
#6
Abdulhamid Alsaeed, Fahad Bamehriz, Sharaf Eldin, Tareq Alzahrani, Abdullah Alharbi, Abdelazeem Eldawlatly
BACKGROUND AND AIM: The aim of this prospective randomized trial is to compare the quality of reversal of rocuronium with either sugammadex (SUG) versus 2.5 mg or 5 mg neostigmine (NEO). PATIENTS AND METHODS: A total of 110 patients with body mass index >40 underwent elective gastric sleeve surgery were enrolled in this study. Exclusion criteria included patients with co-existing muscular and cardiovascular diseases. Patients were randomly allocated to one of the following groups: group A (SUG), Group B (NEO 2...
July 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28731951/does-sugammadex-administration-affect-postoperative-nausea-and-vomiting-after-laparoscopic-cholecystectomy-a-prospective-double-blind-randomized-study
#7
Ayca Tas Tuna, Onur Palabiyik, Mustafa Orhan, Tugba Sonbahar, Havva Sayhan, Yakup Tomak
BACKGROUND: The aim of this study is to assess the effect of sugammadex on postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy. METHODS: Eighty patients who were scheduled for elective laparoscopic cholecystectomy surgery were enrolled in this prospective study. Patients were randomly assigned to neostigmine (group N) or sugammadex (group S) for neuromuscular antagonism at the end of anesthesia. The incidence of PONV and antiemetic consumption were recorded...
August 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28720838/the-efficacy-and-safety-of-sugammadex-for-reversing-postoperative-residual-neuromuscular-blockade-in-pediatric-patients-a-systematic-review
#8
Guangyu Liu, Rui Wang, Yanhong Yan, Long Fan, Jixiu Xue, Tianlong Wang
The aim of this study is to evaluate the efficacy and safety of sugammadex for reversing neuromuscular blockade in pediatric patients. MEDLINE and other three Databases were searched. Randomized clinical trials were included if they compared sugammadex with neostigmine or placebo in pediatric patients undergoing surgery involving the use of rocuronium or vecuronium. The primary outcome was the time interval from administration of reversal agents to train-of-four ratio (TOFr, T4/T1) > 0.9. Incidences of any drug-related adverse events were secondary outcomes...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28714298/effect-of-sugammadex-on-coagulation-as-detected-by-rotational-thromboelastometry-in-morbidly-obese-patients
#9
Michele Carron, Diana Bertini, Tancredi Prandini, Francesca Fanton, Mirto Foletto, Carlo Ori, Egle Perissinotto, Paolo Simioni
BACKGROUND: Sugammadex, which is used to reverse rocuronium-induced neuromuscular blockade, has a limited and transient effect on activated partial thromboplastin time and prothrombin time. However, no data are available on the effects of sugammadex on coagulation in morbidly obese patients, as assessed by rotational thromboelastometry (ROTEM®). METHODS: Sixty patients received sugammadex 2 mg/kg or 4 mg/kg to reverse moderate or deep rocuronium-induced neuromuscular blockade (n = 30/group) at the end of surgery under desflurane anesthesia...
July 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28701612/sugammadex-to-reverse-neuromuscular-blockade-in-a-child-with-a-past-history-of-cardiac-transplantation
#10
Karen Miller, Brian Hall, Joseph D Tobias
Sugammadex is a novel agent for the reversal of neuromuscular blockade. The speed and efficacy of reversal with sugammadex are significantly faster than acetylcholinesterase inhibitors, such as neostigmine. Sugammadex also has a limited adverse profile when compared with acetylcholinesterase inhibitors, specifically in regard to the incidence of bradycardia. This adverse effect may be particularly relevant in the setting of a heart transplant recipient with a denervated heart. The authors present a case of an 8-year-old child, status postcardiac transplantation, who required anesthetic care for laparoscopy and lysis of intra-abdominal adhesions...
July 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28695993/sugammadex-when-should-we-be-giving-it
#11
EDITORIAL
C R Bailey
No abstract text is available yet for this article.
July 11, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28691986/the-role-of-sugammadex-in-symptomatic-transient-neonatal-myasthenia-gravis-a-case-report
#12
Jamie E Rubin, Radhamangalam J Ramamurthi
We describe the case of a 3-week-old boy with pyloric stenosis who presented for laparoscopic pyloromyotomy in the setting of symptomatic transient neonatal myasthenia gravis. The patient received muscle relaxation with rocuronium, and neuromuscular blockade was successfully reversed with sugammadex with recovery guided by train-of-four monitoring. He was extubated uneventfully without complications. Because sugammadex binds directly to rocuronium rather than interfering with acetylcholine metabolism, it might provide a good option for reversal of neuromuscular blockade in transient neonatal myasthenia gravis...
July 6, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28690746/-role-of-rocuronium-sugammadex-algorithm-in-suspension-direct-laryngoscopy
#13
Sidi Driss El Jaouhari, Mohamed Meziane, Redouane Ahtil, Mustapha Bensghir, Charki Haimeur
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28679468/pharmacokinetics-of-sugammadex-in-subjects-with-moderate-and-severe-renal-impairment%C3%A2
#14
K Chris Min, Kenneth C Lasseter, Thomas C Marbury, Rebecca E Wrishko, William D Hanley, Dennis G Wolford, Joanna Udo de Haes, Christina Reitmann, David E Gutstein
AIMS: Sugammadex rapidly reverses moderate and deep rocuronium- or vecuronium-induced neuromuscular blockade at doses of 4 mg/kg and 2 mg/kg, respectively. Sugammadex is renally eliminated. This study evaluated the pharmacokinetics of sugammadex in subjects with renal impairment versus those with normal renal function. METHODS: This open-label, two-part, phase 1 study included adults with moderate (creatinine clearance (CLcr) 30. < 50 mL/min) and severe (CLcr < 30 mL/min) renal impairment and healthy controls (CLcr ≥ 80 mL/min)...
July 6, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28640017/reversal-of-vecuronium-induced-neuromuscular-blockade-with-low-dose-sugammadex-at-train-of-four-count-of-four-a-randomized-controlled-trial
#15
László Asztalos, Zoltán Szabó-Maák, András Gajdos, Réka Nemes, Adrienn Pongrácz, Szabolcs Lengyel, Béla Fülesdi, Edömér Tassonyi
BACKGROUND: Rocuronium-induced neuromuscular block that spontaneously recovered to a train-of-four count of four can be reversed with sugammadex 0.5 or 1.0 mg/kg. We investigated whether these doses of sugammadex can also reverse vecuronium at a similar level of block. METHODS: Sixty-five patients were randomly assigned, and 64 were analyzed in this controlled, superiority study. Participants received general anesthesia with propofol, sevoflurane, fentanyl, and vecuronium...
September 2017: Anesthesiology
https://www.readbyqxmd.com/read/28628514/effects-of-dexamethasone-on-sugammadex-reversal-times-of-rocuronium-a-systematic-review-protocol
#16
Cassie R Held, Mackenzie D Sullivan
The objective of the review is to identify the effect of dexamethasone on reversal times of rocuronium when utilizing sugammadex as the reversal agent. The incidence of the prolonged time to extubation in patients who have received concurrent dexamethasone and sugammadex therapies as opposed to those who have not received dexamethasone will also be examined.The proposed PICO question is as follows: In patients undergoing reversal of aminosteroidal neuromuscular blockade with rocuronium, does dexamethasone administration affect sugammadex reversal times, as compared to patients who have not received dexamethasone?...
June 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28591053/use-of-sugammadex-in-a-patient-with-progressive-muscular-atrophy-and-in-a-patient-with-amyotrophic-lateral-sclerosis-case-report
#17
Jae Hwa Yoo, Soon Im Kim, Sun Young Park, Mi Roung Jun, Yong Eun Kim, Hyoung June Kim
INTRODUCTION: We herein present 2 cases involving the combination of rocuronium and sugammadex in patients with motor neuron disease. The patients were a 54-year-old man with progressive muscular atrophy who underwent removal of internal fixators in the arm and leg, and a 66-year-old woman with amyotrophic lateral sclerosis who underwent skin grafting in the left lower leg. General anesthesia was induced with propofol, rocuronium, and remifentanil and maintained with desflurane and remifentanil...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28585399/current-evidence-for-the-use-of-sugammadex-in-children
#18
Joseph D Tobias
No abstract text is available yet for this article.
July 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28580091/effects-of-sugammadex-on-the-coronary-circulation-direct-effects-on-coronary-vessels-or-hypersensitivity-kounis-syndrome
#19
COMMENT
Hong-Seuk Yang, Ha-Jung Kim, Wonuk Koh
No abstract text is available yet for this article.
June 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28552090/deep-neuromuscular-blockade-and-low-insufflation-pressure-during-laparoscopic-hysterectomy
#20
Matias Vested Madsen, Olav Istre, Henrik Halvor Springborg, Anne Kathrine Staehr-Rye, Jacob Rosenberg, Jørgen Lund, Mona Ring Gätke
INTRODUCTION: Establishment of sufficient muscle relaxation is essential in laparoscopic surgery. During laparoscopy, surgeons can experience abdominal contractions in their patients. Deep neuromuscular block (NMB) has the potential to prevent such episodes. In this study, we explored if deep NMB reduces the incidence of sudden abdominal contractions as compared with standard NMB. METHODS: This was a pre-planned secondary analysis of a randomized, controlled study...
May 2017: Danish Medical Journal
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