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Fetal restriction

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https://www.readbyqxmd.com/read/28526753/altered-feto-placental-vascularization-feto-placental-malperfusion-and-fetal-growth-restriction-in-mice-with-egfl7-loss-of-function
#1
Lauretta A Lacko, Romulo Hurtado, Samantha Hinds, Michael G Poulos, Jason M Butler, Heidi Stuhlmann
EGFL7 is a secreted, angiogenic factor produced by embryonic endothelial cells. To understand its role in placental development, we established a novel Egfl7 knockout mouse. The mutant mice have gross defects in chorioallantoic branching morphogenesis and placental vascular patterning. Microangiography and 3D imaging revealed patchy perfusion of Egfl7(-/-) placentas marked by impeded blood conductance through sites of narrowed vessels. Consistent with poor feto-placental perfusion, Egfl7 knockout resulted in reduced placental weight and fetal growth restriction...
May 19, 2017: Development
https://www.readbyqxmd.com/read/28522651/pregnancy-and-glomerular-disease-a-systematic-review-of-the-literature-with-management-guidelines
#2
Kimberly Blom, Ayodele Odutayo, Kate Bramham, Michelle A Hladunewich
During pregnancy, CKD increases both maternal and fetal risk. Adverse maternal outcomes include progression of underlying renal dysfunction, worsening of urine protein, and hypertension, whereas adverse fetal outcomes include fetal loss, intrauterine growth restriction, and preterm delivery. As such, pregnancy in young women with CKD is anxiety provoking for both the patient and the clinician providing care, and because the heterogeneous group of glomerular diseases often affects young women, this is an area of heightened concern...
May 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28522033/placenta-directed-gene-therapy-for-fetal-growth-restriction
#3
REVIEW
Tara Krishnan, Anna L David
Fetal growth restriction (FGR) is a serious pregnancy complication affecting ∼8% of all pregnancies. There is no treatment to increase fetal growth in the uterus. Gene therapy presents a promising treatment strategy for FGR, with the use of adenoviral vectors encoding for proteins such as vascular endothelial growth factor (VEGF) and insulin-like growth factor demonstrating improvements in fetal growth, placental function, and neonatal outcome in preclinical studies. Safety assessments suggest no adverse risk to the mother or fetus for VEGF maternal gene therapy; a clinical trial is in development...
May 15, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28520809/antenatal-coffee-and-tea-consumption-and-the-effect-on-birth-outcome-and-hypertensive-pregnancy-disorders
#4
Timothy van der Hoeven, Joyce L Browne, Cuno S P M Uiterwaal, Cornelis K van der Ent, Diederick E Grobbee, Geertje W Dalmeijer
BACKGROUND AND OBJECTIVE: Coffee and tea are commonly consumed during pregnancy. While several of their components, like caffeine, have strong pharmacological effects, the effect on the unborn fetus remains unclear. Caffeine intake has been associated with abortion, preterm birth and fetal growth restriction, but a general consensus on caffeine restriction is still lacking. We aimed to investigate antenatal coffee, tea and caffeine consumption and the effect on birth weight and length, gestational age at birth and hypertensive disorders in pregnancy...
2017: PloS One
https://www.readbyqxmd.com/read/28514879/growth-restriction-identifying-fetuses-at-risk
#5
Heidi K Leftwich, Bethany Stetson, Bethany Sabol, Katherine Leung, Judith U Hibbard, Isabelle Wilkins
PURPOSE: Examine risks of intrauterine growth restriction (IUGR) and composite perinatal outcomes with estimated fetal weights (EFW) 10-20(th)%, and compare outcomes using umbilical artery Doppler (UAD). MATERIALS AND METHODS: Retrospective, cohort evaluating ultrasound (US) EFW 10th-20(th)%, between 2002-2012. Cases were identified with EFW % 10-20. Controls, EFW >20(th)% were obtained for each case, matched by gestational age and US date. Unadjusted and adjusted logistic regression was used for outcomes...
May 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28508694/online-versus-offline-spatiotemporal-image-correlation-stic-m-mode-for-the-evaluation-of-cardiac-longitudinal-annular-displacement-in-fetal-growth-restriction
#6
Jozien C Tanis, Nuruddin Mohammed, Mar Bennasar, Josep Maria Martinez, Bart Bijnens, Fatima Crispi, Eduard Gratacos
PURPOSE: Our first aim was to compare online M-mode with offline spatiotemporal image correlation (STIC) M-mode for assessing longitudinal annular displacement (LAD) in growth restricted fetuses (FGR). Our second aim was to compare LAD measures of FGR cases with controls. MATERIALS AND METHODS: Prospective study including 40 FGR cases (defined estimated fetal weight and birth weight <10(th) centile) and 72 normally grown fetuses matched to cases by gestational age at scan...
May 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28506493/strategies-for-investigating-the-maternal-fetal-interface-in-the-first-trimester-of-pregnancy-what-can-we-learn-about-pathology
#7
Judith E Cartwright, Guy StJ Whitley
The pathologies of the pregnancy complications pre-eclampsia (PE) and fetal growth restriction (FGR) are established in the first trimester of human pregnancy. In a normal pregnancy, decidual spiral arteries are transformed into wide diameter, non-vasoactive vessels capable of meeting the increased demands of the developing fetus for nutrients and oxygen. Disruption of this transformation is associated with PE and FGR. Very little is known of how these first trimester changes are regulated normally and even less is known about how they are compromised in complicated pregnancies...
May 6, 2017: Placenta
https://www.readbyqxmd.com/read/28503744/treatment-using-tadalafil-for-severe-pre-eclampsia-with-fetal-growth-restriction
#8
Hiroaki Tanaka, Michiko Kubo, Masafumi Nii, Sintarou Maki, Takashi Umekawa, Tomoaki Ikeda
For severe pre-eclampsia (PE) with fetal growth restriction (FGR), the only effective treatment is early delivery of the placenta. Clinicians are often forced to end the pregnancy because of maternal indications. We report a case of severe PE with FGR in which the PE was temporarily improved and pregnancy successfully prolonged with tadalafil, a phosphodiesterase 5 inhibitor. A 35-year-old primigravid woman presented at 27 3/7 weeks of gestation with severe PE and FGR. After commencing tadalafil administration, biochemical and angiogenic markers improved...
May 15, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28502262/effects-of-combined-iugr-and-prenatal-stress-on-the-development-of-the-hippocampus-in-a-fetal-guinea-pig-model
#9
A L Cumberland, H K Palliser, P Rani, D W Walker, J J Hirst
Intrauterine growth restriction (IUGR) and maternal stress during pregnancy are two compromises that negatively impact neurodevelopment and increase the risk of developing later life neuropsychiatric disorders such as schizophrenia, depression and behavioural disorders. Neurosteroids, particularly allopregnanolone, are important in protecting the developing brain and promoting many essential neurodevelopmental processes. Individually, IUGR and prenatal stress (PS) reduce myelination and neurogenesis within affected fetal brains, however less information is available on the combined effects of these two disorders on the term fetal brain...
May 15, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28501282/proteinuria-in-preeclampsia-not-essential-to-diagnosis-but-related-to-disease-severity-and-fetal-outcomes
#10
Xin Dong, Wenli Gou, Chunfang Li, Min Wu, Zhen Han, Xuelan Li, Qi Chen
Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality globally and proteinuria can be one of the cardinal features of this disease. However, studies about the association of the amount of proteinuria and the severity of preeclampsia, and perinatal outcomes are limited. Data on 239 women with preeclampsia were retrospectively collected from a university teaching hospital from September 2011 to June 2013 and analysed. Data included all clinical parameters and proteinuria in a 24h urine collection...
April 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/28501276/diagnosis-of-preeclampsia-and-fetal-growth-restriction-with-the-sflt-1-plgf-ratio-diagnostic-accuracy-of-the-automated-immunoassay-kryptor%C3%A2
#11
Lisa Antonia Dröge, Alice Höller, Laura Ehrlich, Stefan Verlohren, Wolfgang Henrich, Frank Holger Perschel
OBJECTIVE: We aimed to characterize the diagnostic accuracy of the Kryptor® assay for sFlt-1 and PlGF in maternal serum samples of uneventful singleton pregnancies and subjects with preeclampsia (PE) and PE-related outcomes such as fetal growth restriction (FGR). Longitudinal reference ranges of the sFlt-1 and PlGF level in the course of normal pregnancies were generated. METHODS: A cohort of subjects with PE and PE-related outcomes including FGR in the third trimester was compared to a cohort of women with uneventful outcome...
April 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/28500823/aflatoxin-exposure-during-pregnancy-maternal-anemia-and-adverse-birth-outcomes
#12
Laura E Smith, Andrew J Prendergast, Paul C Turner, Jean H Humphrey, Rebecca J Stoltzfus
AbstractPregnant women and their developing fetuses are vulnerable to multiple environmental insults, including exposure to aflatoxin, a mycotoxin that may contaminate as much as 25% of the world food supply. We reviewed and integrated findings from studies of aflatoxin exposure during pregnancy and evaluated potential links to adverse pregnancy outcomes. We identified 27 studies (10 human cross-sectional studies and 17 animal studies) assessing the relationship between aflatoxin exposure and adverse birth outcomes or anemia...
April 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28500672/telomere-length-and-fetal-programming-a-review-of-recent-scientific-advances
#13
Valerie E Whiteman, Anjali Goswami, Hamisu M Salihu
We sought to synthesize a comprehensive literature review comprising recent research linking fetal programming to fetal telomere length. We also explored the potential effects fetal telomere length shortening has on fetal phenotypes. Utilizing the PubMed database as our primary search engine, we retrieved and reviewed 165 articles of published research. The inclusion criteria limited the articles to those that appeared within the last ten years, were pertinent to humans, and without restriction to language of publication...
May 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28493842/mesenchymal-stem-cell-infiltration-during-neoplastic-transformation-of-the-human-prostate
#14
W Nathaniel Brennen, Baohui Zhang, Ibrahim Kulac, L Nelleke Kisteman, Lizamma Antony, Hao Wang, Alan K Meeker, Angelo M De Marzo, Isla P Garraway, Samuel R Denmeade, John T Isaacs
Mesenchymal Stem Cells (MSCs) have been identified in prostate cancer, raising the critical question of their physical and temporal source. Therefore, MSCs were quantified and characterized in benign and malignant prostate tissue representing different disease states and a wide range of age groups from fetal development through adult death using analytical and functional methodologies. In contrast to lineage-restricted Mesenchymal Progenitor Cells (MPCs) found in normal prostate tissue, MSCs with tri-lineage differentiation potential (adipogenesis, osteogenesis, and chondrogenesis) are identified in prostate tissue from a subset of men with prostate cancer, consistent with an influx of more stem-like progenitors (i...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28490449/enhanced-insulin-secretion-and-insulin-sensitivity-in-young-lambs-with-placental-insufficiency-induced-intrauterine-growth-restriction
#15
Leticia E Camacho, Xiaochuan Chen, William W Hay, Sean W Limesand
Intrauterine growth restriction (IUGR) is associated with persistent metabolic complications, but information is limited for IUGR infants. We determined glucose-stimulated insulin secretion (GSIS) and insulin sensitivity in young lambs with placental insufficiency-induced IUGR. Lambs with hyperthermia-induced IUGR (n=7) were compared to control lambs (n=8). GSIS was measured at 8±1 days of age, and at 15±1 days body weight-specific glucose utilization rates were measured with radiolabeled D-glucose during a hyperinsulinemic-euglycemic clamp (HEC)...
May 10, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28490370/behavioral-interventions-to-promote-adequate-sleep-among-women-protocol-for-a-systematic-review-and-meta-analysis
#16
Lydi-Anne Vézina-Im, Jennette Palcic Moreno, Theresa A Nicklas, Tom Baranowski
BACKGROUND: Short and poor sleep have been associated with adverse health outcomes in adults, such as overweight/obesity and type 2 diabetes, especially among women. Women therefore represent an important target for interventions aimed at improving sleep and such interventions have been advocated to enhance maternal, fetal, and infant health. This systematic review will assess the efficacy or effectiveness of behavioral interventions aimed at promoting adequate sleep among women. The primary outcomes will be changes in sleep duration and/or sleep quality from baseline to post-intervention and to the last available follow-up measured either through self-reports or objectively...
May 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28489914/mir-27a-and-mir-449b-polymorphisms-associated-with-a-risk-of-idiopathic-recurrent-pregnancy-loss
#17
HyungChul Rah, Ki Wha Chung, Ki Han Ko, Eun Sun Kim, Jung Oh Kim, Jung Hyun Sakong, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
OBJECTIVE: MicroRNAs (miRNAs) regulate gene expression during the peri-implantation period. The purpose of this study was to investigate whether genetic polymorphisms in the four miRNAs associated with fetal or placental development play roles in the development of idiopathic recurrent pregnancy loss (RPL) in Korean females. STUDY DESIGN: A case-control study involving 225 controls and 387 women with at least two consecutively recurrent pregnancy losses between 1999 and 2012 was performed...
2017: PloS One
https://www.readbyqxmd.com/read/28486599/antenatal-blockade-of-nmda-receptors-by-memantine-reduces-the-susceptibility-to-diabetes-induced-by-a-high-fat-diet-in-rats-with-intrauterine-growth-restriction
#18
Xiao-Ting Huang, Shao-Jie Yue, Chen Li, Jia Guo, Yan-Hong Huang, Jian-Zhong Han, Dan-Dan Feng, Zi-Qiang Luo
Intrauterine growth retardation (IUGR) is closely related to the later development of type 2 diabetes in adulthood. Excessive activation of glutamate receptors causes excitatory neurotoxicity, which is primarily mediated by N-methyl-D-aspartate receptors (NMDARs), resulting in neuronal injury or death. Inhibition of NMDARs enhances the GSIS and survival of islet cells in type 2 diabetic mouse and human islets. Here, we examined whether antenatal blockade of NMDARs by Memantine could decrease the risk of diabetes induced by a high-fat (HF) diet at adulthood in IUGR rats...
May 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28484595/fetal-and-neonatal-programming-of-postnatal-growth-and-feed-efficiency-in-swine
#19
REVIEW
Yun Ji, Zhenlong Wu, Zhaolai Dai, Xiaolong Wang, Ju Li, Binggen Wang, Guoyao Wu
Maternal undernutrition or overnutrition during pregnancy alters organ structure, impairs prenatal and neonatal growth and development, and reduces feed efficiency for lean tissue gains in pigs. These adverse effects may be carried over to the next generation or beyond. This phenomenon of the transgenerational impacts is known as fetal programming, which is mediated by stable and heritable alterations of gene expression through covalent modifications of DNA and histones without changes in DNA sequences (namely, epigenetics)...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28483844/perinatal-outcomes-in-multifetal-pregnancy-following-fetal-reduction
#20
Neda Razaz, Tehila Avitan, Joseph Ting, Tracy Pressey, K S Joseph
BACKGROUND: There is currently insufficient evidence regarding the prognosis of multifetal pregnancy following elective fetal reduction to twin or singleton pregnancy. We compared perinatal outcomes in pregnancies with and without fetal reduction. METHODS: We used data on all stillbirths and live births in British Columbia, Canada, from 2009 to 2013. We compared outcomes of multifetal pregnancies with fetal reduction (to twin or singleton pregnancy) with outcomes of pregnancies without fetal reduction...
May 8, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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