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https://www.readbyqxmd.com/read/28938612/magnetic-resonance-imaging-tracking-and-assessing-repair-function-of-the-bone-marrow-mesenchymal-stem-cells-transplantation-in-a-rat-model-of-spinal-cord-injury
#1
Hongwu Zhang, Liqin Wang, Shihong Wen, Qingfeng Xiang, Xianhong Xiang, Caixia Xu, Yong Wan, Jingnan Wang, Bin Li, Yiqian Wan, Zhiyun Yang, David Y B Deng
The transplantation of bone marrow mesenchymal stem cells (BMSCs) to repair spinal cord injury (SCI) has become a promising therapy. However, there is still a lack of visual evidence directly implicating the transplanted cells as the source of the improvement of spinal cord function. In this study, BMSCs were labeled with NF-200 promoter and lipase-activated gadolinium-containing nanoparticles (Gd-DTPA-FA). Double labeled BMSCs were implanted into spinal cord transaction injury in rat models in situ, the function recovery was evaluated on 1st, 7th, 14th, 28 th days by MRI, Diffusion Tensor Imaing, CT imaging and post-processing, and histological observations...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937828/the-effects-of-systemic-alfuzosin-and-tamsulosin-hydrochloride-on-choroidal-thickness-and-pupil-diameter-sizes-in-cases-with-benign-prostatic-hyperplasia
#2
Mustafa Dogan, Bunyamin Kutluksaman, Ibrahim Keles, Mustafa Karalar, Ahmet Omer Halat
PURPOSE: To compare the effects of alfuzosin hydrochloride and tamsulosin hydrochloride on choroidal thickness (CT) and pupil diameter (PD) sizes in patients with benign prostatic hyperplasia. SUBJECTS AND METHODS: Sixty-three men patients with newly diagnosis of benign prostatic hyperplasia were randomly assigned to either alfuzosin hydrochloride or to tamsulosin hydrochloride groups in this prospective, randomized, parallel-group clinical trial. Enhanced depth imaging spectral-domain optical coherence tomography, pupillography were obtained at baseline, 1st and 3rd month, and choroidal thicknesses and pupil diameter sizes were compared between the two groups...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937826/choroidal-variations-in-diabetic-macular-edema-fluorescein-angiography-and-optical-coherence-tomography
#3
Xiangning Wang, Shuting Li, Wei Li, Yanjun Hua, Qiang Wu
PURPOSES: To (i) evaluate variations in choroidal thickness (CT) and choroidal volume (CV) in diabetic macular edema (DME), as demonstrated by fluorescein angiography (FA) and enhanced depth-imaging (EDI) optical coherence tomography (OCT) (EDI-OCT) and (ii) correlate these variations with visual acuity. METHODS: This study was a retrospective observational case series of patients with diabetic retinopathy (DR) and DME. The study groups comprised 77 DR patients (n = 87), all of whom underwent color fundus photography, FA, and OCT on the same day...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937510/advancements-in-staging-and-imaging-for-penile-cancer
#4
Sarah R Ottenhof, Andrew R Leone, Simon Horenblas, Philippe E Spiess, Erik Vegt
PURPOSE OF REVIEW: We review recent advancements in staging and imaging of penile cancer, including surveillance after therapy. RECENT FINDINGS: For cN0 patients, the sentinel lymph node biopsy is currently considered the preferred way for invasive staging. It has largely replaced other modalities such as staging inguinal lymphadenectomy. Its diagnostic value increases when combined with other staging modalities such as ultrasound with fine-needle aspiration cytology (US-FNAC) or fluorodeoxyglucose-PET with computed tomography (PET/CT)...
September 20, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28937494/high-pitch-coronary-computed-tomographic-angiography-using-the-third-generation-dual-source-computed-tomography-initial-experience-in-patients-with-high-heart-rate
#5
Ruiqi Feng, Jingsong Mao, Xiaofei Liu, Yu Zhao, Jiajie Tong, Liang Zhang
OBJECTIVE: This study aimed to evaluate the feasibility, image quality, and radiation dose of prospectively high-pitch coronary computed tomographic (CT) angiography in patients with high heart rates (HRs) using the third-generation dual-source CT. METHODS: One hundred consecutive patients with sinus rhythm and HR between 70 and 100 beats per minute were enrolled into this study. All patients were divided into 2 groups. Patients in group A (n = 46) were examined with prospectively high-pitch scan mode in which image acquisition was triggered at 30% of the R-R interval...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937491/improved-calcium-scoring-at-dual-energy-computed-tomography-angiography-using-a-high-z-contrast-element-and-novel-material-separation-technique
#6
Jack W Lambert, Yuxin Sun, Karen G Ordovas, Robert G Gould, Sizhe Wang, Benjamin M Yeh
OBJECTIVES: The aim of this study was to compare the accuracy of existing dual-energy computed tomography (CT) angiography coronary artery calcium scoring methods to those obtained using an experimental tungsten-based contrast material and a recently described contrast material extraction process (CMEP). METHODS: Phantom coronary arteries of varied diameters, with different densities and arcs of simulated calcified plaque, were sequentially filled with water, iodine, and tungsten contrast materials and scanned within a thorax phantom at rapid-kVp-switching dual-energy CT...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937286/comparing-subjective-and-objective-image-quality-at-two-different-radiation-exposure-ranges-of-the-paranasal-sinus-ct-examinations-using-a-volumetric-320-row-detector-ct-system
#7
Berhan Pirimoglu, Recep Sade, Muhammed Sedat Sakat, Hayri Ogul, Suat Eren, Mecit Kantarci
OBJECTIVES: To evaluate image quality of protocol including 135 kVp, 5 mAs and 80 kVp, 5 mAs in the paranasal sinus CT examinations using single volumetric 320-row multidetector CT technique. METHODS: From September to December 2016, both of our control group including 135 kVp and 5 mAs and our study group including 80 kVp and 5 mAs paranasal CT protocols were simultaneously performed on 40 patients using single volumetric 320-row multidetector CT device. Image quality for bony structures, air-filled structures and soft tissues were independently assessed for each group by three blinded observers using a 3-point grading scale (0 = not diagnostic, 1 = partially diagnostic, 2 = diagnostic)...
September 21, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28937280/lingual-tonsillolith-prevalence-and-imaging-characteristics-evaluated-on-2244-pairs-of-panoramic-radiographs-and-ct-images
#8
Akira Takahashi, Chieko Sugawara, Keiko Kudoh, Yoshiko Yamamura, Go Ohe, Tetsuya Tamatani, Youji Miyamoto
OBJECTIVES: Lingual tonsilloliths are not as well-known to radiologists than palatine tonsilloliths, although they might be common in clinical practice. The aim of this investigation was to clarify the prevalence and imaging characteristics of lingual tonsilloliths using panoramic radiographs and computed tomography (CT) images. SUBJECTS AND METHODS: This study included 2244 patients without pathology at the base of tongue who underwent panoramic radiography and CT of the maxillofacial region...
September 20, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28936988/reducing-radiation-exposure-with-iterative-reconstruction-an-inter-and-intra-scanner-analysis
#9
Aaron Rohr, Jo Wick, Jacqueline Hill, Carissa Walter, Neville Irani, Shaun Best, Kirk Miller, Ryan Ash
Our purpose in this study was to compare delivered radiation exposure via Computed Tomography Dose Index Volume (CTDIvol) and Dose Length Production (DLP) measurements from computed tomography (CT) examinations performed on scanners with and without image-quality enhancing iterative reconstruction (IR) software. A retrospective analysis was conducted on randomly selected chest, abdomen, and/or pelvis CT examinations from three different scanners from January 1, 2013 to December 31, 2013. CTDIvol and DLP measurements were obtained from two CT scanners with and one CT scanner without IR software...
September 22, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28936892/initial-experience-with-cinematic-rendering-for-chest-cardiovascular-imaging
#10
Steven Rowe, Pamela Johnson, Elliot Fishman
Three-dimensional (3D) computed tomography (CT) with volume rendering (VR) and maximum intensity projection (MIP) is an integral component of CT interpretation for diagnosis and treatment planning of vascular pathology. Cinematic rendering (CR is a new rendering algorithm that incorporates a more advanced lighting model than that used for VR, to create photorealistic 3D CT images. The post-processing tool is not yet widely available and its ultimate clinical utility has yet to be assessed in well-designed studies...
September 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936888/dual-energy-ct-applications-in-pancreatic-pathologies
#11
Elizabeth George, Jeremy R Wortman, Urvi P Fulwadhva, Jennifer W Uyeda, Aaron D Sodickson
Dual energy CT is a technology that is gaining widespread acceptance, particularly for its abdominopelvic applications. Pancreatic pathologies are an ideal application for the many advantages offered by dual energy post-processing. This article reviews the current literature on dual energy CT pancreatic imaging, specifically in the evaluation of pancreatic adenocarcinoma, other solid and cystic pancreatic neoplasms, and pancreatitis. The advantages in characterization and quantification of enhancement, detection of subtle lesions, and potential reduction of imaging phases and contrast usage are reviewed...
September 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936780/ct-based-spect-attenuation-correction-and-assessment-of-infarct-size-results-from-a-cardiac-phantom-study
#12
Alexander Stephan Kroiss, Stephan Gerhard Nekolla, Georg Dobrozemsky, Thomas Grubinger, Barry Lynn Shulkin, Markus Schwaiger
RATIONALE: Myocardial perfusion SPECT is a commonly performed, well established, clinically useful procedure for the management of patients with coronary artery disease. However, the attenuation of photons from myocardium impacts the quantification of infarct sizes. CT-Attenuation Correction (AC) potentially resolves this problem. This contention was investigated by analyzing various parameters for infarct size delineation in a cardiac phantom model. METHODS: A thorax phantom with a left ventricle (LV), fillable defects, lungs, spine and liver was used...
September 21, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28936756/clinical-utility-of-mri-brain-in-children-with-non-traumatic-coma
#13
Jatinder Khipal, Naveen Sankhyan, Sunit C Singhi, Pratibha Singhi, Niranjan Khandelwal
OBJECTIVES: To determine characteristics that help identify children with acute encephalopathy who benefit from an MRI (magnetic resonance imaging) of the brain. The secondary objective was to determine the adverse events associated with the MRI procedure. METHODS: In this single center, prospective, observational study. Children (2 mo - 12 y) presenting with impaired consciousness were screened. Those with acute non-traumatic encephalopathy (Glasgow Coma Score of 12 or less) undergoing their first in-patient MRI brain were included...
September 22, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28936704/extraction-of-the-subpleural-lung-region-from-computed-tomography-images-to-detect-interstitial-lung-disease
#14
Tae Iwasawa, Yuma Iwao, Tamiko Takemura, Koji Okudela, Toshiyuki Gotoh, Tomohisa Baba, Takashi Ogura, Mari S Oba
PURPOSE: To quantify lesions in the subpleural lung region (SubPL) on computed tomography (CT) images and to evaluate whether they are useful for detecting interstitial lung disease (ILD). MATERIALS AND METHODS: The subjects were 40 patients with idiopathic pulmonary fibrosis (IPF) diagnosed by multidisciplinary methods and 35 age-matched patients without ILDs. The lungs and SubPL were extracted from CT images using a Gaussian histogram normalized correlation system and evaluated for the mean CT attenuation value (CTmean) and the percentage of high attenuation area (%HAA), exceeding -700 Hounsfield units...
September 21, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28936631/the-hourglass-sign
#15
REVIEW
Aina Venkatasamy, Tri Thai Huynh, Bénédicte Caron, Francis Veillon
The Hourglass sign is a useful imaging clue for diagnosing diaphragmatic ruptures with viscera herniation on multidetector CT, with a sensitivity ranging from 16% to 63% and a specificity around 98%-100%. This sign is also commonly found in the literature under the name "Collar sign," first described in 1995 by Worthy et al. It refers to the waistlike constriction of the herniated structure at the site of the diaphragmatic rupture.
September 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28936605/sex-determination-of-a-tunisian-population-by-ct-scan-analysis-of-the-skull
#16
Malek Zaafrane, Mehdi Ben Khelil, Ines Naccache, Ekbel Ezzedine, Frédéric Savall, Norbert Telmon, Najla Mnif, Moncef Hamdoun
It is widely accepted that the estimation of biological attributes in the human skeleton is more accurate when population-specific standards are applied. With the shortage of such data for contemporary North African populations, it is duly required to establish population-specific standards. We present here the first craniometric standards for sex determination of a contemporary Tunisian population. The aim of this study was to analyze the correlation between sex and metric parameters of the skull in this population using CT scan analysis and to generate proper reliable standards for sex determination of a complete or fragmented skull...
September 21, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28936568/distracting-injury-defined-does-an-isolated-hip-fracture-constitute-a-distracting-injury-for-clearance-of-the-cervical-spine
#17
Ryan Lindborg, Amani Jambhekar, Vincent Chan, Daniel Laskey, James Rucinski, Bashar Fahoum
OBJECTIVES: As the population within the USA ages, the number of hip fractures seen yearly in the emergency department is expected to rise. According to the NEXUS criteria, many of these patients receive computerized tomographic scan (CT) evaluation of the cervical spine because a hip fracture may constitute a distracting injury. The objective of this study is to determine if an isolated hip fracture constitutes a distracting injury which requires imaging of the cervical spine. METHODS: Data were prospectively collected on 158 trauma patients with isolated hip fractures between April 1, 2015 and March 9, 2016...
September 21, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28935898/pd-l1-is-an-activation-independent-marker-of-brown-adipocytes
#18
Jessica R Ingram, Michael Dougan, Mohammad Rashidian, Marko Knoll, Edmund J Keliher, Sarah Garrett, Scott Garforth, Olga S Blomberg, Camilo Espinosa, Atul Bhan, Steven C Almo, Ralph Weissleder, Harvey Lodish, Stephanie K Dougan, Hidde L Ploegh
Programmed death ligand 1 (PD-L1) is expressed on a number of immune and cancer cells, where it can downregulate antitumor immune responses. Its expression has been linked to metabolic changes in these cells. Here we develop a radiolabeled camelid single-domain antibody (anti-PD-L1 VHH) to track PD-L1 expression by immuno-positron emission tomography (PET). PET-CT imaging shows a robust and specific PD-L1 signal in brown adipose tissue (BAT). We confirm expression of PD-L1 on brown adipocytes and demonstrate that signal intensity does not change in response to cold exposure or β-adrenergic activation...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935854/comparison-of-helical-tomotherapy-and-direct-tomotherapy-in-bilateral-whole-breast-irradiation-in-a-case-of-bilateral-synchronous-grade-1-and-stage-1-breast-cancer
#19
Valentina Lancellotta, Martina Iacco, Elisabetta Perrucci, Claudio Zucchetti, Anna Concetta Dipilato, Lorenzo Falcinelli, Isabella Palumbo, Cynthia Aristei
BACKGROUND Synchronous bilateral breast cancer is rare. A case is presented where whole breast irradiation (WBI) was planned after breast conserving surgery in a patient with synchronous bilateral breast cancer. A comparison was made between the feasibility of helical tomotherapy and direct tomotherapy. CASE REPORT A 60-year-old woman was found to have bilateral breast nodules on routine mammographic screening, resulting in bilateral lumpectomy and sentinel lymph node biopsy. Histopathology showed a 6 mm diameter invasive ductal carcinoma in the right breast (Grade 1, hormone receptor positive, HER2 negative) and an 8mm diameter tubular carcinoma in the left breast (Grade 1, hormone receptor positive, HER2 negative)...
September 22, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28935835/total-body-pet-maximizing-sensitivity-to-create-new-opportunities-for-clinical-research-and-patient-care
#20
Simon R Cherry, Terry Jones, Joel S Karp, Jinyi Qi, William Moses, Ramsey Badawi
Positron emission tomography (PET) is widely considered as the most sensitive technique available for non-invasively studying physiology, metabolism and molecular pathways in the living human being. However, the utility of PET, being a photon deficient modality, remains constrained by factors including low signal-to-noise ratio (SNR), long imaging times and concerns regarding radiation dose. Two developments offer the potential to dramatically increase the effective sensitivity of PET. First by increasing the geometric coverage to encompass the entire body, sensitivity can be increased by a factor of ~40 for total-body imaging or a factor of ~4-5 for imaging a single organ such as the brain or heart...
September 21, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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