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https://www.readbyqxmd.com/read/28214353/association-of-gastro-oesophageal-reflux-and-chronic-rhinosinusitis-systematic-review-and-meta-analysis
#1
S R Leason, H P Barham, G Oakley, J Rimmer, J M DelGaudio, J M Christensen, R Sacks, R J Harvey
INTRODUCTION: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS). The association of GORD with CRS is systematically assessed from the medical literature. METHODOLOGY: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included...
February 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28198887/femtosecond-two-photon-planar-laser-induced-fluorescence-of-carbon-monoxide-in-flames
#2
Daniel R Richardson, Sukesh Roy, James R Gord
Two-photon, planar laser-induced fluorescence (TP-PLIF) of carbon monoxide was performed in steady and driven flames using femtosecond (fs) laser pulses at 1 kHz. Excitation radiation at 230.1 nm (full-width at half-maximum bandwidth of 270  cm<sup>-1</sup>) was used to pump many rovibrational two-photon transitions in the B<sup>1</sup>∑<sup>+</sup>←X<sup>1</sup>∑<sup>+</sup> system. Visible fluorescence in the range 362-516 nm was captured using an image intensifier and high-speed camera...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28179588/tp53-based-interaction-analysis-identifies-cis-eqtl-variants-for-tp53bp2-fbxo28-and-fam53a-that-associate-with-survival-and-treatment-outcome-in-breast-cancer
#3
Rainer Fagerholm, Sofia Khan, Marjanka K Schmidt, Montserrat García-Closas, Päivi Heikkilä, Jani Saarela, Jonathan Beesley, Maral Jamshidi, Kristiina Aittomäki, Jianjun Liu, H Raza Ali, Irene L Andrulis, Matthias W Beckmann, Sabine Behrens, Fiona M Blows, Hermann Brenner, Jenny Chang-Claude, Fergus J Couch, Kamila Czene, Peter A Fasching, Jonine Figueroa, Giuseppe Floris, Gord Glendon, Qi Guo, Per Hall, Emily Hallberg, Ute Hamann, Bernd Holleczek, Maartje J Hooning, John L Hopper, Agnes Jager, Maria Kabisch, Renske Keeman, Veli-Matti Kosma, Diether Lambrechts, Annika Lindblom, Arto Mannermaa, Sara Margolin, Elena Provenzano, Mitul Shah, Melissa C Southey, Joe Dennis, Michael Lush, Kyriaki Michailidou, Qin Wang, Manjeet K Bolla, Alison M Dunning, Douglas F Easton, Paul D P Pharoah, Georgia Chenevix-Trench, Carl Blomqvist, Heli Nevanlinna
TP53 overexpression is indicative of somatic TP53 mutations and associates with aggressive tumors and poor prognosis in breast cancer. We utilized a two-stage SNP association study to detect variants associated with breast cancer survival in a TP53-dependent manner. Initially, a genome-wide study (n = 575 cases) was conducted to discover candidate SNPs for genotyping and validation in the Breast Cancer Association Consortium (BCAC). The SNPs were then tested for interaction with tumor TP53 status (n = 4,610) and anthracycline treatment (n = 17,828)...
February 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28166807/non-invasive-optical-spectroscopic-monitoring-of-breast-development-during-puberty
#4
Lothar Lilge, Mary Beth Terry, Jane Walter, Dushanthi Pinnaduwage, Gord Glendon, Danielle Hanna, Mai-Liis Tammemagi, Angela Bradbury, Saundra Buys, Mary Daly, Esther M John, Julia A Knight, Irene L Andrulis
BACKGROUND: Tanner staging (TS), a five-stage classification indicating no breast tissue (TS1) to full breast development (TS5), is used both in health research and clinical care to assess the onset of breast development (TS2) and duration in each stage. Currently, TS is measured both visually and through palpation but non-invasive methods will improve comparisons across settings. METHODS: We used optical spectroscopy (OS) measures from 102 girls at the Ontario site of the LEGACY girls study (average age 12 years, range 10...
February 6, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28158901/long-term-symptom-control-of-gastro-oesophageal-reflux-disease-12-years-after-laparoscopic-nissen-or-180%C3%A2-anterior-partial-fundoplication-in-a-randomized-clinical-trial
#5
D J Roks, J A Broeders, R J Baigrie
BACKGROUND: Laparoscopic 180° anterior fundoplication has been shown to achieve similar reflux control to Nissen fundoplication, with fewer side-effects, up to 5 years. However, there is a paucity of long-term follow-up data on this technique and antireflux surgery in general. This study reports 12-year outcomes of a double-blind RCT comparing laparoscopic Nissen versus 180° laparoscopic anterior fundoplication for gastro-oesophageal reflux disease (GORD). METHODS: Patients with proven GORD were randomized to laparoscopic Nissen or 180° anterior fundoplication...
February 3, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28158042/high-speed-two-dimensional-synchrotron-white-beam-x-ray-radiography-of-spray-breakup-and-atomization
#6
Benjamin R Halls, Christopher D Radke, Benjamin J Reuter, Alan L Kastengren, James R Gord, Terrence R Meyer
High-speed, two-dimensional synchrotron x-ray radiography and phase-contrast imaging are demonstrated in propulsion sprays. Measurements are performed at the 7-BM beamline at the Advanced Photon Source user facility at Argonne National Laboratory using a recently developed broadband x-ray white beam. This novel enhancement allows for high speed, high fidelity x-ray imaging for the community at large. Quantitative path-integrated liquid distributions and spatio-temporal dynamics of the sprays were imaged with a LuAG:Ce scintillator optically coupled to a high-speed CMOS camera...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28151751/adam-eve-and-the-reflux-enigma-age-and-sex-differences-across-the-gastro-oesophageal-reflux-spectrum
#7
Christine Royston, Karna D Bardhan
INTRODUCTION: We present demographic differences across the gastro-oesophageal reflux disease (GORD) spectrum in a UK District General Hospital. PATIENTS AND METHODS: Data were prospectively collected over 37 years. At endoscopy patients were categorized as: erosive oesophagitis (EO), Barrett's oesophagus (BO) or nonerosive reflux disease (NER). Analysis 1: comparison of EO, BO and NER 1977-2001 when the database for GORD without BO closed. Analysis 2: demographic differences in oesophageal adenocarcinoma (OAC) in total BO population diagnosed 1977-2011...
February 1, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28148574/peroral-endoscopic-myotomy-a-literature-review-and-the-first-uk-case-series
#8
Shraddha Gulati, Andrew Emmanuel, Haruhiro Inoue, Bu'Hussain Hayee, Amyn Haji
Peroral endoscopic myotomy (POEM) is an established treatment for primary achalasia. It has gained endorsement from the American Society for Gastrointestinal Endoscopy with increasing clinical acceptance since the first procedure, performed in Japan in 2008. The first successful POEM in the UK was performed in November 2013 at King's College Hospital and this article presents the first UK case series. Prospective data were collected at 3 and 12-24 months for consecutive patients undergoing POEM. Post-POEM gastro-oesophageal reflux health-related quality of life scale (GORD-HRQoL) score was recorded...
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28135121/robotic-assisted-minimally-invasive-total-esophagogastric-dissociation-for-children-with-severe-neurodisability
#9
Girolamo Mattioli, Francesco Molinaro, Irene Paraboschi, Lorenzo Leonelli, Cinzia Mazzola, Serena Arrigo, Margherita Mancardi, Alessio Pini Prato, Rossella Angotti, Mario Messina, Adrian Bianchi
BACKGROUND: Around 70% of children with neurodisability (ND) present pharyngeal neuromuscular incoordination and severe gastroesophageal reflux disease (GORD). METHODS: This is a pilot study with the Robotic-assisted minimally invasive total esophagogastric dissociation (TOGD). RESULTS: We included 4 patients, 2 males and 2 females, with ND and severe GORD refractory to medical treatment. CONCLUSIONS: Pharmacological management of GORD is often unsuccessful and antireflux surgery is common, but it has a high failure rate with symptom recurrence, requiring re-do surgery...
January 30, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28128689/symmetry-of-the-arcuate-fasciculus-and-its-impact-on-language-performance-of-patients-with-brain-tumors-in-the-language-dominant-hemisphere
#10
Margit Jehna, Juliane Becker, Karla Zaar, Gord von Campe, Kariem Mahdy Ali, Gernot Reishofer, Franz Payer, Michael Synowitz, Franz Fazekas, Christian Enzinger, Hannes Deutschmann
OBJECTIVE Cerebral damage in frontal, parietal, and temporal brain areas and, probably more importantly, their interconnections can lead to deficits in language. However, neural plasticity and repair allow the brain to partly compensate for neural injury, mediated by both functional and structural changes. In this study, the authors sought to systematically investigate the relationship between language performance in brain tumor patients and structural perisylvian pathways (i.e., the arcuate fasciculus [AF]) using probabilistic fiber tracking on diffusion tensor imaging...
January 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28059341/high-speed-three-dimensional-tomographic-laser-induced-incandescence-imaging-of-soot-volume-fraction-in-turbulent-flames
#11
Terrence R Meyer, Benjamin R Halls, Naibo Jiang, Mikhail N Slipchenko, Sukesh Roy, James R Gord
High-speed, laser-based tomographic imaging of the three-dimensional time evolution of soot volume fraction in turbulent jet diffusion flames is demonstrated to be feasible at rates of 10 kHz or higher. The fundamental output of a burst-mode Nd:YAG laser with 1 J/pulse is utilized for volumetric impulsive heating of soot particles with a laser fluence of 0.1 J/cm<sup>2</sup>, enabling signal-to-noise ratios of ~100:1 in images of the resulting incandescence. The three-dimensional morphology of the soot distribution is captured with a spatial resolution of <1...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28043480/the-integrated-comprehensive-care-program-a-novel-home-care-initiative-after-major-thoracic-surgery
#12
Yaron Shargall, Wael C Hanna, Laura Schneider, Colin Schieman, Christian J Finley, Anna Tran, Shantel Demay, Carolyn Gosse, James M Bowen, Gord Blackhouse, Kevin Smith
The objective of the study was to evaluate the Integrated Comprehensive Care (ICC) program, a novel health system integration initiative that coordinates home care and hospital-based clinical services for patients undergoing major thoracic surgery relative to traditional home care delivery. Methods included a pilot retrospective cohort analysis that compared the intervention cohort (ICC), composed of all patients undergoing major thoracic surgery in the 2012-2013 fiscal year with a control cohort, who underwent surgery in the year before the initiation of ICC...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27960645/combined-therapy-in-children-and-adolescents-with-classical-hodgkin-s-lymphoma-a-report-from-the-sfce-on-mdh-03-national-guidelines
#13
E Seror, J Donadieu, H Pacquement, S Abbou, A Lambilliotte, M Schell, C Curtillet, V Gandemer, M Pasquet, N Aladjidi, P Lutz, C Schmitt, A Deville, O Minckes, J P Vanier, C Armari-Alla, C Thomas, S Gorde-Grosjean, F Millot, P Blouin, N Garnier, C Coze, C Devoldere, Y Reguerre, S Helfre, L Claude, J Clavel, O Oberlin, J Landman-Parker, T Leblanc
Hodgkin's lymphoma (HL) in children and adolescents is highly curable, but children are at risk of long-term toxicity. The MDH-03 guidelines were established in order to decrease the burden of treatment in good-responder patients, and this report should be considered a step toward further optimization of treatment within large collaborative trials. We report the therapy and long-term outcomes of 417 children and adolescents treated according to the national guidelines, which were applied between 2003 and 2007 in France...
October 2016: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27904862/risk-factors-for-barrett-s-oesophagus
#14
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Globally, the incidence of OAC is rising. Furthermore, the prognosis regarding the morbidity and mortality of OAC is bleak, with an estimated 5-year survival of 10-15%. Hence, detection of the premalignant phase is paramount. Endoscopy and biopsy sampling is the mainstay of diagnosis. Patients may present with symptoms of gastro-oesophageal reflux disease (GORD) or be completely asymptomatic...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27889625/cortical-interneuron-specification-the-juncture-of-genes-time-and-geometry
#15
REVIEW
Rachel C Bandler, Christian Mayer, Gord Fishell
A fundamental question in developmental neuroscience is how hundreds of diverse cell types are generated to form specialized brain regions. The ganglionic eminences (GEs) are embryonic brain structures located in the ventral telencephalon that produce many inhibitory GABA (γ-Aminobutyric acid)-ergic cell types, including long-range projection neurons and local interneurons (INs), which disperse widely throughout the brain. While much has been discovered about the origin and wiring of these cells, a major question remains: how do neurons originating in the GEs become specified during development as one differentiated subtype versus another? This review will cover recent work that has advanced our knowledge of the mechanisms governing cortical interneuron subtype specification, particularly progenitors' spatial origin, birthdates, lineage, and mode of division...
November 24, 2016: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/27846485/human-brains-teach-us-a-surprising-lesson
#16
Melissa McKenzie, Gord Fishell
No abstract text is available yet for this article.
October 7, 2016: Science
https://www.readbyqxmd.com/read/27845421/rs2735383-located-at-a-microrna-binding-site-in-the-3-utr-of-nbs1-is-not-associated-with-breast-cancer-risk
#17
Jingjing Liu, Ivona Lončar, J Margriet Collée, Manjeet K Bolla, Joe Dennis, Kyriaki Michailidou, Qin Wang, Irene L Andrulis, Monica Barile, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Carl Blomqvist, Bram Boeckx, Natalia V Bogdanova, Stig E Bojesen, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Jenny Chang-Claude, Shou-Tung Chen, Georgia Chenevix-Trench, Ching Y Cheng, Ji-Yeob Choi, Fergus J Couch, Angela Cox, Simon S Cross, Katarina Cuk, Kamila Czene, Thilo Dörk, Isabel Dos-Santos-Silva, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Graham G Giles, Gord Glendon, Mark S Goldberg, Anna González-Neira, Pascal Guénel, Christopher A Haiman, Ute Hamann, Steven N Hart, Mikael Hartman, Sigrid Hatse, John L Hopper, Hidemi Ito, Anna Jakubowska, Maria Kabisch, Daehee Kang, Veli-Matti Kosma, Vessela N Kristensen, Loic Le Marchand, Eunjung Lee, Jingmei Li, Artitaya Lophatananon, Jan Lubinski, Arto Mannermaa, Keitaro Matsuo, Roger L Milne, Susan L Neuhausen, Heli Nevanlinna, Nick Orr, Jose I A Perez, Julian Peto, Thomas C Putti, Katri Pylkäs, Paolo Radice, Suleeporn Sangrajrang, Elinor J Sawyer, Marjanka K Schmidt, Andreas Schneeweiss, Chen-Yang Shen, Martha J Shrubsole, Xiao-Ou Shu, Jacques Simard, Melissa C Southey, Anthony Swerdlow, Soo H Teo, Daniel C Tessier, Somchai Thanasitthichai, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-Chen Tseng, Celine Vachon, Robert Winqvist, Anna H Wu, Drakoulis Yannoukakos, Wei Zheng, Per Hall, Alison M Dunning, Douglas F Easton, Maartje J Hooning, Ans M W van den Ouweland, John W M Martens, Antoinette Hollestelle
NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27836394/pre-and-postoperative-neurocognitive-deficits-in-brain-tumor-patients-assessed-by-a-computer-based-screening-test
#18
Markus Hoffermann, Lukas Bruckmann, Kariem Mahdy Ali, Karla Zaar, Alexander Avian, Gord von Campe
Neurocognitive assessment becomes increasingly important in neuro-oncology. The presence and degree of neurocognitive deficits in patients with brain tumors appear to be important not only as outcome measures but also in treatment planning and as possible prognostic markers for tumor-progression. Common screening methods for neurocognitive deficits are often insufficient in uncovering subtle changes or harbor the risk of being observer-dependent and time-consuming. We present data of brain tumor patients screened by a computer-based neurocognitive assessment tool before and after surgery...
February 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27836010/inheritance-of-deleterious-mutations-at-both-brca1-and-brca2-in-an-international-sample-of-32-295-women
#19
Timothy R Rebbeck, Tara M Friebel, Nandita Mitra, Fei Wan, Stephanie Chen, Irene L Andrulis, Paraskevi Apostolou, Norbert Arnold, Banu K Arun, Daniel Barrowdale, Javier Benitez, Raanan Berger, Pascaline Berthet, Ake Borg, Saundra S Buys, Trinidad Caldes, Jonathan Carter, Jocelyne Chiquette, Kathleen B M Claes, Fergus J Couch, Cezary Cybulski, Mary B Daly, Miguel de la Hoya, Orland Diez, Susan M Domchek, Katherine L Nathanson, Katarzyna Durda, Steve Ellis, D Gareth Evans, Lenka Foretova, Eitan Friedman, Debra Frost, Patricia A Ganz, Judy Garber, Gord Glendon, Andrew K Godwin, Mark H Greene, Jacek Gronwald, Eric Hahnen, Emily Hallberg, Ute Hamann, Thomas V O Hansen, Evgeny N Imyanitov, Claudine Isaacs, Anna Jakubowska, Ramunas Janavicius, Katarzyna Jaworska-Bieniek, Esther M John, Beth Y Karlan, Bella Kaufman, KConFab Investigators, Ava Kwong, Yael Laitman, Christine Lasset, Conxi Lazaro, Jenny Lester, Niklas Loman, Jan Lubinski, Siranoush Manoukian, Gillian Mitchell, Marco Montagna, Susan L Neuhausen, Heli Nevanlinna, Dieter Niederacher, Robert L Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Sue Kyung Park, Marion Piedmonte, Paolo Radice, Christine Rappaport-Fuerhauser, Matti A Rookus, Caroline Seynaeve, Jacques Simard, Christian F Singer, Penny Soucy, Melissa Southey, Dominique Stoppa-Lyonnet, Grzegorz Sukiennicki, Csilla I Szabo, Mariella Tancredi, Manuel R Teixeira, Soo-Hwang Teo, Mary Beth Terry, Mads Thomassen, Laima Tihomirova, Marc Tischkowitz, Amanda Ewart Toland, Aleksandra Toloczko-Grabarek, Nadine Tung, Elizabeth J van Rensburg, Danylo Villano, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N Weitzel, Jamal Zidan, Kristin K Zorn, Lesley McGuffog, Douglas Easton, Georgia Chenevix-Trench, Antonis C Antoniou, Susan J Ramus
BACKGROUND: Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations in both BRCA1 and BRCA2 are rare, and the consequences of transheterozygosity are poorly understood. METHODS: From 32,295 female BRCA1/2 mutation carriers, we identified 93 TH (0.3 %). "Cases" were defined as TH, and "controls" were single mutations at BRCA1 (SH1) or BRCA2 (SH2). Matched SH1 "controls" carried a BRCA1 mutation found in the TH "case"...
November 11, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27828437/1-khz-two-dimensional-coherent-anti-stokes-raman-scattering-2d-cars-for-gas-phase-thermometry
#20
Joseph D Miller, Mikhail N Slipchenko, Jason G Mance, Sukesh Roy, James R Gord
Two-dimensional gas-phase coherent anti-Stokes Raman scattering (2D-CARS) thermometry is demonstrated at 1 kHz in a heated jet. A hybrid femtosecond/picosecond CARS configuration is used in a two-beam phase-matching arrangement with a 100-femtosecond pump/Stokes pulse and a 107-picosecond probe pulse. The femtosecond pulse is generated using a mode-locked oscillator and regenerative amplifier that is synchronized to a separate picosecond oscillator and burst-mode amplifier. The CARS signal is spectrally dispersed in a custom imaging spectrometer and detected using a high-speed camera with image intensifier...
October 31, 2016: Optics Express
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