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https://www.readbyqxmd.com/read/28776330/multidimensional-assessment-of-severe-asthma-a-systematic-review-and-meta-analysis
#1
REVIEW
Vanessa L Clark, Peter G Gibson, Grayson Genn, Sarah A Hiles, Ian D Pavord, Vanessa M McDonald
The management of severe asthma is complex. Multidimensional assessment (MDA) of specific traits has been proposed as an effective strategy to manage severe asthma, although it is supported by few prospective studies. We aimed to systematically review the literature published on MDA in severe asthma, to identify the traits included in MDA and to determine the effect of MDA on asthma-related outcomes. We identified 26 studies and classified these based on study type (cohort/cross-sectional studies; experimental/outcome studies; and severe asthma disease registries)...
August 3, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28761563/the-emerging-role-of-the-eosinophil-and-its-measurement-in-chronic-cough
#2
REVIEW
Mahboobeh H Sadeghi, Alyn H Morice
Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastro-oesophageal reflux disease (GORD), and upper airways disease, the inflammatory mechanisms underlying these conditions differ. Recent studies on asthma have increasingly focused on its molecular phenotypes instead of clinical characteristics. Here, we proposed the hypothesis that divides cough into two groups; the eosinophilic and neutrophilic. This division will enhance our ability to recognise the type of airway inflammation which, as a consequence will lead us to more targeted and personalized treatment approaches...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28751897/comparative-agronomic-performance-and-reaction-to-fusarium-wilt-of-lens-culinaris-%C3%A3-l-orientalis-and-l-culinaris-%C3%A3-l-ervoides-derivatives
#3
Mohar Singh, Jai C Rana, Badal Singh, Sandeep Kumar, Deep R Saxena, Ashok Saxena, Aqeel H Rizvi, Ashutosh Sarker
The development of transgressive phenotype in the segregating populations has been speculated to contribute to niche divergence of hybrid lineages, which occurs most frequently at larger genetic distances. Wild Lens species are considered to be more resistant against major biotic and abiotic stresses than that of the cultivated species. In the present study, we assessed the comparative agronomic performance of lentil (Lens culinaris subsp. culinaris) inter-sub-specific (L. culinaris subsp. orientalis) and interspecific (L...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28733768/estimates-of-health-utility-scores-in-chronic-kidney-disease
#4
Nigar Sekercioglu, Bryan Curtis, Sean Murphy, Gord Blackhouse, Brendan Barrett
INTRODUCTION: Coverage decisions in publicly funded healthcare systems require a formal, systematic and transparent assessment process for policies related to distribution of resources. The process is complex and employs multiple types of information, such as clinical effectiveness, costs and health utility scores which are used to produce quality-adjusted life years. The purpose of this study was to create health utility scores for CKD patients within the Canadian population. METHODS: This is a cross-sectional study of CKD patients...
July 21, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28708180/4d-spatiotemporal-evolution-of-combustion-intermediates-in-turbulent-flames-using-burst-mode-volumetric-laser-induced-fluorescence
#5
Benjamin R Halls, Naibo Jiang, Terrence R Meyer, Sukesh Roy, Mikhail N Slipchenko, James R Gord
High-speed (20 kHz rate), volumetric laser-induced-fluorescence imaging of combustion intermediates such as a formaldehyde (CH<sub>2</sub>O) and polycyclic aromatic hydrocarbon (PAH) species is demonstrated for tracking the four-dimensional (4D) evolution of turbulent flames. The third-harmonic, 355 nm output of a burst-mode Nd:YAG laser with a 130 mJ/pulse is expanded to 30 mm diameter for volume illumination of the base region of a methane-hydrogen jet diffusion flame. Eight simultaneous images from different viewing angles are used to collect the resulting fluorescence signal for reconstruction of 200 time-sequential three-dimensional volumes over 10 ms duration...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28702854/gastroesophageal-reflux-disease-and-pulmonary-diseases-associated-with-aspergillosis-is-there-a-connection
#6
Maria N Gamaletsou, David W Denning
INTRODUCTION: We studied the relationship between GORD and allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), or Aspergillus bronchitis. BACKGROUND: Gastroesophageal reflux disease (GORD) is well known to initiate or exacerbate pulmonary inflammatory conditions, inducing bronchial asthma and chronic obstructive lung disease. METHODS: We reviewed four patients referred with elevated Aspergillus serology markers and marked pulmonary symptoms for ABPA, CPA, and Aspergillus bronchitis, and discussed the underlying pathophysiological relationship with GORD...
July 12, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28701952/a-systematic-review-of-the-immune-regulating-and-anticancer-activities-of-pseudolaric-acid-b
#7
REVIEW
Mei-Lun Liu, Dan Sun, Tan Li, Hong Chen
Cortex pseudolaricis, the root bark of Pseudolarix kaempferi Gord, has been used to treat tinea and other skin diseases for the antimicrobial activities in Traditional Chinese Medicine (TCM). Pseudolaric acid B (PAB) has been identified as the major component responsible for the action of C. pseudolaricis. Recently, PAB has been demonstrated to be used as novel treatments for cancer, immune disorders, inflammatory diseases, and immunosuppression. However, the mechanisms through which PAB exerts its properties are not understood well, and little attention in the literature has been given to review its pharmacological activities before...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28689187/acupuncture-for-the-treatment-of-gastro-oesophageal-reflux-disease-a-systematic-review-and-meta-analysis
#8
Jiajie Zhu, Yu Guo, Shan Liu, Xiaolan Su, Yijie Li, Yang Yang, Liwei Hou, Guishu Wang, Jiaxin Zhang, Jiande Jd Chen, Qingguo Wang, Ruhan Wei, Wei Wei
BACKGROUND: Gastro-oesophageal reflux disease (GORD) is one of the most common diseases presenting to gastroenterology clinics. Acupuncture is widely used as a complementary and alternative treatment for patients with GORD. OBJECTIVE: To explore the effectiveness of acupuncture for the treatment of GORD. METHODS: Four English and four Chinese databases were searched through June 2016. Randomised controlled trials investigating the effectiveness of manual acupuncture or electroacupuncture (MA/EA) for GORD versus or as an adjunct to Western medicine (WM) were selected...
July 8, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/28676124/evaluation-of-rational-nonsteroidal-anti-inflammatory-drugs-and-gastro-protective-agents-use-association-rule-data-mining-using-outpatient-prescription-patterns
#9
Oraluck Pattanaprateep, Mark McEvoy, John Attia, Ammarin Thakkinstian
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) and gastro-protective agents should be co-prescribed following a standard clinical practice guideline; however, adherence to this guideline in routine practice is unknown. This study applied an association rule model (ARM) to estimate rational NSAIDs and gastro-protective agents use in an outpatient prescriptions dataset. METHODS: A database of hospital outpatients from October 1st, 2013 to September 30th, 2015 was searched for any of following drugs: oral antacids (A02A), peptic ulcer and gastro-oesophageal reflux disease drugs (GORD, A02B), and anti-inflammatory and anti-rheumatic products, non-steroids or NSAIDs (M01A)...
July 4, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28653691/corrigendum-a-viral-strategy-for-targeting-and-manipulating-interneurons-across-vertebrate-species
#10
Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu, Michael C Avery, Mohammad S Rashid, Myungin Baek, Amanda L Jacob, Gordon B Smith, Daniel E Wilson, Georg Kosche, Illya Kruglikov, Tomasz Rusielewicz, Vibhakar C Kotak, Todd M Mowery, Stewart A Anderson, Edward M Callaway, Jeremy S Dasen, David Fitzpatrick, Valentina Fossati, Michael A Long, Scott Noggle, John H Reynolds, Dan H Sanes, Bernardo Rudy, Guoping Feng, Gord Fishell
No abstract text is available yet for this article.
June 27, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28653689/addendum-a-viral-strategy-for-targeting-and-manipulating-interneurons-across-vertebrate-species
#11
Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu, Michael C Avery, Mohammad S Rashid, Myungin Baek, Amanda L Jacob, Gordon B Smith, Daniel E Wilson, Georg Kosche, Illya Kruglikov, Tomasz Rusielewicz, Vibhakar C Kotak, Todd M Mowery, Stewart A Anderson, Edward M Callaway, Jeremy S Dasen, David Fitzpatrick, Valentina Fossati, Michael A Long, Scott Noggle, John H Reynolds, Dan H Sanes, Bernardo Rudy, Guoping Feng, Gord Fishell
No abstract text is available yet for this article.
June 27, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28600380/cohort-profile-the-nordic-antireflux-surgery-cohort-nordasco
#12
John Maret-Ouda, Karl Wahlin, Miia Artama, Nele Brusselaers, Martti Färkkilä, Elsebeth Lynge, Fredrik Mattsson, Eero Pukkala, Pål Romundstad, Laufey Tryggvadóttir, My von Euler-Chelpin, Jesper Lagergren
PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. PARTICIPANTS: Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964-2014 (with various start and end years in different countries)...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28516204/a-novel-dynamic-statistical-model-for-predicting-patient-satisfaction-with-fundoplication-based-on-pre-operative-symptom-patterns
#13
B L Woodham, R Meng, R H Roberts
BACKGROUND: Fundoplication provides excellent control of gastro-oesophageal reflux disease (GORD), but there remain a number of unsatisfied patients who have proven difficult to identify pre-operatively. We hypothesised that pre-operative symptom patterns can predict of the risk of post-operative dissatisfaction. METHODS: Pre-operative symptoms and post-operative satisfaction were measured using standardised questionnaires along with routine investigations. These data were used to calculate our novel pre-operative risk of dissatisfaction (PROD) score...
May 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28506663/cough-associated-with-gastro-oesophageal-reflux-disease-gord-japanese-experience
#14
REVIEW
Akio Niimi
Differences in the aetiology as well as patient background of chronic cough have been recognised among US, UK, and Japan. One of the marked differences has been the prevalence of gastro-oesophageal reflux disease (GORD), which has been one of the top three causes in Western countries. It was indeed uncommon or rare in Japan, but, with the increasing prevalence of GOR itself, chronic cough associated with GORD seems to have become more common. In this article, cough associated with GORD will be reviewed based on literature and our Japanese experience...
May 12, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28449828/hypertension-canada-s-2017-guidelines-for-diagnosis-risk-assessment-prevention-and-treatment-of-hypertension-in-adults
#15
Alexander A Leung, Stella S Daskalopoulou, Kaberi Dasgupta, Kerry McBrien, Sonia Butalia, Kelly B Zarnke, Kara Nerenberg, Kevin C Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Sheldon W Tobe, Marcel Ruzicka, Kevin D Burns, Michel Vallée, G V Ramesh Prasad, Steven E Gryn, Ross D Feldman, Peter Selby, Andrew Pipe, Ernesto L Schiffrin, Philip A McFarlane, Paul Oh, Robert A Hegele, Milan Khara, Thomas W Wilson, S Brian Penner, Ellen Burgess, Praveena Sivapalan, Robert J Herman, Simon L Bacon, Simon W Rabkin, Richard E Gilbert, Tavis S Campbell, Steven Grover, George Honos, Patrice Lindsay, Michael D Hill, Shelagh B Coutts, Gord Gubitz, Norman R C Campbell, Gordon W Moe, Jonathan G Howlett, Jean-Martin Boulanger, Ally Prebtani, Gregory Kline, Lawrence A Leiter, Charlotte Jones, Anne-Marie Côté, Vincent Woo, Janusz Kaczorowski, Luc Trudeau, Ross T Tsuyuki, Swapnil Hiremath, Denis Drouin, Kim L Lavoie, Pavel Hamet, Jean C Grégoire, Richard Lewanczuk, George K Dresser, Mukul Sharma, Debra Reid, Scott A Lear, Gregory Moullec, Milan Gupta, Laura A Magee, Alexander G Logan, Janis Dionne, Anne Fournier, Geneviève Benoit, Janusz Feber, Luc Poirier, Raj S Padwal, Doreen M Rabi
Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis, assessment, prevention, and treatment of hypertension. This year, we introduce 10 new guidelines. Three previous guidelines have been revised and 5 have been removed. Previous age and frailty distinctions have been removed as considerations for when to initiate antihypertensive therapy. In the presence of macrovascular target organ damage, or in those with independent cardiovascular risk factors, antihypertensive therapy should be considered for all individuals with elevated average systolic nonautomated office blood pressure (non-AOBP) readings ≥ 140 mm Hg...
May 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28448241/prediction-of-breast-and-prostate-cancer-risks-in-male-brca1-and-brca2-mutation-carriers-using-polygenic-risk-scores
#16
Julie Lecarpentier, Valentina Silvestri, Karoline B Kuchenbaecker, Daniel Barrowdale, Joe Dennis, Lesley McGuffog, Penny Soucy, Goska Leslie, Piera Rizzolo, Anna Sara Navazio, Virginia Valentini, Veronica Zelli, Andrew Lee, Ali Amin Al Olama, Jonathan P Tyrer, Melissa Southey, Esther M John, Thomas A Conner, David E Goldgar, Saundra S Buys, Ramunas Janavicius, Linda Steele, Yuan Chun Ding, Susan L Neuhausen, Thomas V O Hansen, Ana Osorio, Jeffrey N Weitzel, Angela Toss, Veronica Medici, Laura Cortesi, Ines Zanna, Domenico Palli, Paolo Radice, Siranoush Manoukian, Bernard Peissel, Jacopo Azzollini, Alessandra Viel, Giulia Cini, Giuseppe Damante, Stefania Tommasi, Paolo Peterlongo, Florentia Fostira, Ute Hamann, D Gareth Evans, Alex Henderson, Carole Brewer, Diana Eccles, Jackie Cook, Kai-Ren Ong, Lisa Walker, Lucy E Side, Mary E Porteous, Rosemarie Davidson, Shirley Hodgson, Debra Frost, Julian Adlard, Louise Izatt, Ros Eeles, Steve Ellis, Marc Tischkowitz, Andrew K Godwin, Alfons Meindl, Andrea Gehrig, Bernd Dworniczak, Christian Sutter, Christoph Engel, Dieter Niederacher, Doris Steinemann, Eric Hahnen, Jan Hauke, Kerstin Rhiem, Karin Kast, Norbert Arnold, Nina Ditsch, Shan Wang-Gohrke, Barbara Wappenschmidt, Dorothea Wand, Christine Lasset, Dominique Stoppa-Lyonnet, Muriel Belotti, Francesca Damiola, Laure Barjhoux, Sylvie Mazoyer, Mattias Van Heetvelde, Bruce Poppe, Kim De Leeneer, Kathleen B M Claes, Miguel de la Hoya, Vanesa Garcia-Barberan, Trinidad Caldes, Pedro Perez Segura, Johanna I Kiiski, Kristiina Aittomäki, Sofia Khan, Heli Nevanlinna, Christi J van Asperen, Tibor Vaszko, Miklos Kasler, Edith Olah, Judith Balmaña, Sara Gutiérrez-Enríquez, Orland Diez, Alex Teulé, Angel Izquierdo, Esther Darder, Joan Brunet, Jesús Del Valle, Lidia Feliubadalo, Miquel Angel Pujana, Conxi Lazaro, Adalgeir Arason, Bjarni A Agnarsson, Oskar Th Johannsson, Rosa B Barkardottir, Elisa Alducci, Silvia Tognazzo, Marco Montagna, Manuel R Teixeira, Pedro Pinto, Amanda B Spurdle, Helene Holland, Jong Won Lee, Min Hyuk Lee, Jihyoun Lee, Sung-Won Kim, Eunyoung Kang, Zisun Kim, Priyanka Sharma, Timothy R Rebbeck, Joseph Vijai, Mark Robson, Anne Lincoln, Jacob Musinsky, Pragna Gaddam, Yen Y Tan, Andreas Berger, Christian F Singer, Jennifer T Loud, Mark H Greene, Anna Marie Mulligan, Gord Glendon, Irene L Andrulis, Amanda Ewart Toland, Leigha Senter, Anders Bojesen, Henriette Roed Nielsen, Anne-Bine Skytte, Lone Sunde, Uffe Birk Jensen, Inge Sokilde Pedersen, Lotte Krogh, Torben A Kruse, Maria A Caligo, Sook-Yee Yoon, Soo-Hwang Teo, Anna von Wachenfeldt, Dezheng Huo, Sarah M Nielsen, Olufunmilayo I Olopade, Katherine L Nathanson, Susan M Domchek, Christa Lorenchick, Rachel C Jankowitz, Ian Campbell, Paul James, Gillian Mitchell, Nick Orr, Sue Kyung Park, Mads Thomassen, Kenneth Offit, Fergus J Couch, Jacques Simard, Douglas F Easton, Georgia Chenevix-Trench, Rita K Schmutzler, Antonis C Antoniou, Laura Ottini
Purpose BRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We investigated-for the first time to our knowledge-associations of common genetic variants with breast and prostate cancer risks for male carriers of BRCA1/ 2 mutations and implications for cancer risk prediction. Materials and Methods We genotyped 1,802 male carriers of BRCA1/2 mutations from the Consortium of Investigators of Modifiers of BRCA1/2 by using the custom Illumina OncoArray...
July 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28442495/aspirin-prevents-nf-%C3%AE%C2%BAb-activation-and-cdx2-expression-stimulated-by-acid-and-bile-salts-in-oesophageal-squamous-cells-of-patients-with-barrett-s-oesophagus
#17
Xiaofang Huo, Xi Zhang, Chunhua Yu, Edaire Cheng, Qiuyang Zhang, Kerry B Dunbar, Thai H Pham, John P Lynch, David H Wang, Robert S Bresalier, Stuart J Spechler, Rhonda F Souza
OBJECTIVE: In previous studies using oesophageal squamous cells from patients with Barrett's oesophagus (normal oesophageal squamous (NES)-B cells) and from patients without Barrett's oesophagus (NES-G cells), we showed that acid and bile salts induced caudal-related homeobox transcription factor 2 (CDX2) expression only in NES-B cells. CDX2, a transcription factor required to form intestinal epithelium, is a target of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling, which can be inhibited by aspirin...
April 25, 2017: Gut
https://www.readbyqxmd.com/read/28441928/canadian-stroke-best-practice-recommendations-telestroke-best-practice-guidelines-update-2017
#18
Dylan Blacquiere, M Patrice Lindsay, Norine Foley, Colleen Taralson, Susan Alcock, Catherine Balg, Sanjit Bhogal, Julie Cole, Marsha Eustace, Patricia Gallagher, Antoinette Ghanem, Alexander Hoechsmann, Gary Hunter, Khurshid Khan, Alier Marrero, Brian Moses, Kelley Rayner, Andrew Samis, Elisabeth Smitko, Marilyn Vibe, Gord Gubitz, Dariush Dowlatshahi, Stephen Phillips, Frank L Silver
Every year, approximately 62,000 people with stroke and transient ischemic attack are treated in Canadian hospitals. The 2016 update of the Canadian Stroke Best Practice Recommendations Telestroke guideline is a comprehensive summary of current evidence-based and consensus-based recommendations appropriate for use by all healthcare providers and system planners who organize and provide care to patients following stroke across a broad range of settings. These recommendations focus on the use of telemedicine technologies to rapidly identify and treat appropriate patients with acute thrombolytic therapies in hospitals without stroke specialized expertise; select patients who require to immediate transfer to stroke centers for Endovascular Therapy; and for the patients who remain in community hospitals to facilitate their care on a stroke unit and provide remote access to stroke prevention and rehabilitation services...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28425716/reactions-of-n2o5-with-salty-and-surfactant-coated-glycerol-interfacial-conversion-of-br-to-br2-mediated-by-alkylammonium-cations
#19
Michael A Shaloski, Joseph R Gord, Sean Staudt, Sarah L Quinn, Timothy H Bertram, Gilbert M Nathanson
Gas-liquid scattering and product-yield experiments are used to investigate reactions of N2O5 with glycerol containing Br(-) and surfactant ions. N2O5 oxidizes Br(-) to Br2 for every solution tested: 2.7 M NaBr, 0.03 M tetrahexylammonium bromide (THABr), 0.03 M THABr + 0.5 M NaBr, 0.03 M THABr + 0.5 M NaCl, 0.03 M THABr + 0.01 M sodium dodecyl sulfate (SDS), and 0.01 M cetyltrimethylammonium bromide (CTABr). N2O5 also reacts with glycerol itself to produce mono- and dinitroglycerin. Surface tension measurements indicate that 0...
May 5, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28414346/mixture-fraction-measurements-with-femtosecond-laser-electronic-excitation-tagging
#20
Benjamin R Halls, Naibo Jiang, James R Gord, Paul M Danehy, Sukesh Roy
Tracer-free mixture-fraction measurements were demonstrated in a jet using femtosecond-laser electronic-excitation tagging. Measurements were conducted across a turbulent jet at several downstream locations both in a pure-nitrogen jet exiting into an air-nitrogen mixture and in a jet containing an air-nitrogen mixture exiting into pure nitrogen. The signal was calibrated with known concentrations of oxygen in nitrogen. The spatial resolution of the measurement was ∼180  μm. The measurement uncertainty ranged from 5% to 15%, depending on the mixture fraction and location within the beam, under constant temperature and pressure conditions...
April 10, 2017: Applied Optics
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