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Benzydamine

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https://www.readbyqxmd.com/read/29756749/oral-flurbiprofen-spray-effectively-reduces-postoperative-sore-throat-and-hoarseness-a-prospective-randomized-double-blind-placebo-controlled-study
#1
Togay Muderris, Gunay Tezcan, Mecit Sancak, Fatih Gul, Gokcer Ugur
BACKGROUND: Sore throat and hoarseness are common complications after surgery. Flurbiprofen spray has been successfully used for treatment of oral inflammations, but its effects on postoperative sore throat and hoarseness are unknown. We conducted this study to evaluate the effectiveness of flurbiprofen spray on postoperative sore throat and hoarseness, by comparing it with benzydamine hyrdrochloride spray and placebo. METHODS: One hundred fifty patients who were scheduled to undergo elective ear surgery were enrolled...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29694257/functional-assessment-of-rat-pulmonary-flavin-containing-monooxygenase-activity
#2
Yildiz Yilmaz, Gareth Williams, Nenad Manevski, Markus Walles, Stephan Krähenbühl, Gian Camenisch
1. FMO expression varies extensively between human and commonly used preclinical species such as rat and mouse. The aim of this study was to investigate the pulmonary FMO activity in rat using benzydamine. Furthermore, the contribution of rat lung to the clearance of benzydamine was investigated using an in vivo pulmonary extraction model. 2. Benzydamine N-oxygenation was observed in lung microsomes and lung slices. Thermal inactivation of FMO and CYP inhibition suggested that rat pulmonary N-oxygenation is predominantly FMO mediated while any contribution from CYPs is negligible...
April 25, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29556555/randomized-controlled-trial-to-compare-oral-analgesic-requirements-and-patient-satisfaction-in-using-oral-non-steroidal-anti-inflammatory-drugs-versus-benzydamine-hydrochloride-oral-rinses-after-mandibular-third-molar-extraction-a-pilot-study
#3
Devalina Goswami, Gaurav Jain, Mangesh Mohod, Dalim Kumar Baidya, Ongkila Bhutia, Ajoy Roychoudhury
Background: Third molar extraction is associated with considerable pain and discomfort, which is mostly managed with oral analgesic medication. We assessed the analgesic effect of benzydamine hydrochloride, a topical analgesic oral rinse, for controlling postoperative pain following third molar extraction. Methods: A randomized controlled trial was conducted in 40 patients divided into two groups, for extraction of fully erupted third molar. Groups A received benzydamine hydrochloride mouthwash and group B received normal saline gargle with oral ibuprofen and paracetamol...
February 2018: Journal of Dental Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29492414/comparison-the-pain-relief-of-amitriptyline-mouthwash-with-benzydamine-in-oral-mucositis
#4
Shahla Kakoei, Abbas Pardakhty, Maryam-Al-Sadat Hashemipour, Hasan Larizadeh, Behjat Kalantari, Elaheh Tahmasebi
Statement of the Problem: A significant proportion of patients undergoing chemotherapy or radiotherapy suffer from mucositis. The first symptom of oral mucositis is pain. Severe pain, burning sensation, and discomfort in the oral cavity make it difficult to continue treatment and even continue living in these patients. Purpose: The aim of this study was to evaluate and compare the effect of amitriptyline mouthwash (in two forms of simple and niosomal) as a local anesthetic agent with benzydamine HCl mouthwash in oral mucositis after radiotherapy or chemotherapy...
March 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29377080/topical-benzydamine-hydrochloride-for-prevention-of-postoperative-sore-throat-in-adults-undergoing-tracheal-intubation-for-elective-surgery-a-systematic-review-and-meta-analysis
#5
REVIEW
A Kuriyama, M Aga, H Maeda
Postoperative sore throat has a negative impact on patient satisfaction and recovery. Benzydamine hydrochloride is a non-steroidal anti-inflammatory drug available for topical use. We performed a systematic review and meta-analysis to assess the efficacy and safety of topical application of benzydamine to prevent postoperative sore throat in adults undergoing elective surgery under general anaesthesia. We searched PubMed, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials to identify relevant randomised controlled trials and pooled the data using a random effects model...
January 29, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29259628/relative-efficacy-of-quercetin-compared-with-benzydamine-hydrochloride-in-minor-aphthae-a-prospective-parallel-double-blind-active-control-preliminary-study
#6
Maitreyi Pandya, Anupama N Kalappanavar, Rajeshwari G Annigeri, Dhanya S Rao
Background and Objectives: Recurrent aphthous stomatitis is an inflammatory condition present since ancient era wherein numerous treatment modalities have been tried. But complete eradication of the disease has not been possible and hence newer agents are being introduced. One such agent is a flavonoid named quercetin with proven antioxidant, anti-inflammatory, and ulcer healing properties. Methods: 40 patients with minor aphthous ulcers were divided equally into two groups: A and B...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/29116146/inactivation-mechanism-of-n61s-mutant-of-human-fmo3-towards-trimethylamine
#7
Chongliang Gao, Gianluca Catucci, Silvia Castrignanò, Gianfranco Gilardi, Sheila J Sadeghi
Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies have uncovered a striking correlation between plasma TMAO concentration and cardiovascular disease. Certain mutations within the hFMO3 gene cause defective trimethylamine (TMA) N-oxygenation leading to trimethylaminuria (TMAU) also known as fish-odour syndrome...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28961427/comparison-of-clinical-efficacies-of-preoperatively-initiated-naproxen-sodium-codeine-phosphate-in-combination-diclofenac-potassium-and-benzydamine-hydrochloride-for-pain-edema-and-trismus-after-extraction-of-impacted-lower-third-molar-a-randomized-double-blind
#8
Levent Cigerim, Cennet Neslihan Eroglu
PURPOSE: The aim of this study was to compare the clinical efficacies of naproxen sodium-codeine phosphate in combination, benzydamine hydrochloride, and diclofenac potassium for pain, edema, and trismus after lower third molar extraction. MATERIALS AND METHODS: Ninety healthy volunteers in whom impacted third molar extraction was indicated were randomly distributed into 3 groups. One hour before the tooth-extraction process, patients were administered one of the following drugs: naproxen sodium, 550 mg, and codeine phosphate, 30 mg, in a tablet; diclofenac potassium, 50 mg, in a coated pill; or benzydamine hydrochloride, 50 mg, in a coated pill...
March 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28942587/randomized-control-trial-of-benzydamine-hcl-versus-sodium-bicarbonate-for-prophylaxis-of-concurrent-chemoradiation-induced-oral-mucositis
#9
Imjai Chitapanarux, Tharatorn Tungkasamit, Janjira Petsuksiri, Danita Kannarunimit, Kanyarat Katanyoo, Chakkapong Chakkabat, Jiraporn Setakornnukul, Somying Wongsrita, Naruemon Jirawatwarakul, Chawalit Lertbusayanukul, Patumrat Sripan, Patrinee Traisathit
PURPOSE: The purpose of the study is to compare the efficacy of benzydamine HCl with sodium bicarbonate in the prevention of concurrent chemoradiation-induced oral mucositis in head and neck cancer patients. METHODS: Sixty locally advanced head and neck cancer patients treated with high-dose radiotherapy concurrently with platinum-based chemotherapy were randomly assigned to receive either benzydamine HCl or sodium bicarbonate from the first day of treatment to 2 weeks after the completion of treatment...
March 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28819071/genetic-and-nongenetic-factors-associated-with-protein-abundance-of-flavin-containing-monooxygenase-3-in-human-liver
#10
Meijuan Xu, Deepak Kumar Bhatt, Catherine K Yeung, Katrina G Claw, Amarjit S Chaudhry, Andrea Gaedigk, Robin E Pearce, Ulrich Broeckel, Roger Gaedigk, Deborah A Nickerson, Erin Schuetz, Allan E Rettie, J Steven Leeder, Kenneth E Thummel, Bhagwat Prasad
Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of nucleophilic heteroatom (e.g., N or S )-containing xenobiotics (e.g., amphetamine, sulindac, benzydamine, ranitidine, tamoxifen, nicotine, and ethionamide), as well as endogenous compounds (e.g., catecholamine and trimethylamine). To predict the effect of genetic and nongenetic factors on the hepatic metabolism of FMO3 substrates, we quantified FMO3 protein abundance in human liver microsomes (HLMs; n = 445) by liquid chromatography-tandem mass chromatography proteomics...
November 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28760731/hepatic-flavin-containing-monooxygenase-3-enzyme-suppressed-by-type-1-allergy-produced-nitric-oxide
#11
Tadatoshi Tanino, Toru Bando, Akira Komada, Yukie Nojiri, Yuna Okada, Yukari Ueda, Eiichi Sakurai
Flavin-containing monooxygenases (FMOs) are major mammalian non-cytochrome P450 oxidative enzymes. T helper 2 cell-activated allergic diseases produce excess levels of nitric oxide (NO) that modify the functions of proteins. However, it remains unclear whether allergy-induced NO affects the pharmacokinetics of drugs metabolized by FMOs. This study investigated alterations of hepatic microsomal FMO1 and FMO3 activities in type 1 allergic mice and further examined the interaction of FMO1 and FMO3 with allergy-induced NO...
November 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28442642/vaginal-delivery-of-benzydamine-hydrochloride-through-liposomes-dispersed-in-mucoadhesive-gels
#12
Fatmanur Tuğcu-Demiröz
Liposomal vaginal drug delivery systems are important strategy in the treatment of both topical and systemic diseases. The aim of this study was to develop a vaginal delivery system for benzydamine hydrochloride (BNZ) loaded liposomes dispersed into mucoadhesive gels. The delivery system was also designed for a once a day dosage and to obtain controlled release of the BNZ. For this purpose BNZ containing gel formulations using hydroxypropyl methylcellulose (HPMC) K100M and Carbopol(®) 974P, which are composed of polymers that show promising potential as mucoadhesive vaginal delivery systems, were developed...
July 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28429885/intravenous-self-administration-of-benzydamine-a-non-steroidal-anti-inflammatory-drug-with-a-central-cannabinoidergic-mechanism-of-action
#13
Riccardo Avvisati, Maria Meringolo, Emiliana Stendardo, Elisa Malavasi, Silvia Marinelli, Aldo Badiani
Benzydamine (BZY) is a non-steroidal anti-inflammatory drug used for the topical treatment of inflammations of the oral and vaginal mucosae. Virtually nothing is known about the central pharmacological actions of BZY. Yet there are reports of voluntary systemic overdosage of BZY in drug addicts, resulting in a euphoric, hallucinatory state. In the present study, we investigated the reinforcing properties of BZY in a rat self-administration paradigm. We found that BZY has a powerful reinforcing effect and that this effect is greatly facilitated in animals that already had substance experience, having previously self-administered heroin and cocaine, indicating cross sensitization between BZY and other common drugs of abuse...
March 2018: Addiction Biology
https://www.readbyqxmd.com/read/28352949/from-prescription-only-rx-to-over-the-counter-otc-status-in-germany-2006-2015-pharmacological-perspectives-on-regulatory-decisions
#14
Eva Barrenberg, Edeltraut Garbe
PURPOSE: Little is known about the extent of switches from prescription-only (Rx) to over-the-counter (OTC) status in Europe and about the pharmacological properties of the switched substances. The objectives of this study were to provide an overview of the substances that were switched from Rx to OTC status in Germany between 2006 and 2015 and to assess their pharmacological properties. METHODS: Session minutes of the German Expert Advisory Committee for Prescription-Only Issues, changes to the German Ordinance on Prescription-Only Medicines and the Summary of Product Characteristics of the switched substances were analysed...
July 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28258069/marmoset-flavin-containing-monooxygenase-3-in-the-liver-is-a-major-benzydamine-and-sulindac-sulfide-oxygenase
#15
Shotaro Uehara, Makiko Shimizu, Yasuhiro Uno, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki
Common marmosets (Callithrix jacchus) are potentially primate models for preclinical drug metabolism studies because there are similarities in the molecular characteristics of cytochrome P450 enzymes between this species and humans. However, characterization of non-cytochrome P450 enzymes has not been clarified in marmosets. Here, we report characterization of flavin-containing monooxygenases FMO1-FMO5 identified in marmoset tissues. Marmoset FMO forms shared high amino acid sequence identities (93%-95%) and phylogenetic closeness with human homologous FMO forms...
May 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28247977/burning-mouth-syndrome-a-systematic-review-of-treatments
#16
REVIEW
Y F Liu, Y Kim, T Yoo, P Han, J C Inman
Burning mouth syndrome (BMS) is a chronic oral pain syndrome that primarily affects peri- and postmenopausal women. It is characterized by oral mucosal burning and may be associated with dysgeusia, paresthesia, dysesthesia, and xerostomia. The etiology of the disease process is unknown, but is thought to be neuropathic in origin. The goal of this systematic review was to assess the efficacy of the various treatments for BMS. Literature searches were conducted through PubMed, Web of Science, and Cochrane Library databases, which identified 22 randomized controlled trials...
April 2018: Oral Diseases
https://www.readbyqxmd.com/read/28195065/effect-of-econazole-and-benzydamine-on-sensory-neurons-in-culture
#17
S Mathivanan, R de la Torre-Martinez, C Wolf, G Mangano, L Polenzani, C Milanese, A Ferrer-Montiel
Econazole is an anti-mycotic agent widely used for the treatment of cutaneous fungal infections, and for the therapy of vaginal candidiasis. Topical application of this azole is generally safe, although some patients have complained of mild burning sensation/cutaneous irritation and itching, especially when administered intravaginally. The underlying mechanisms responsible of these adverse effects are poorly understood, though they suggest excitation of cutaneous nociceptor terminals. We report that exposure of primary cultures of rat nociceptors to econazole augments neuronal excitability...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28145791/human-plasma-metabolic-profiles-of-benzydamine-a-flavin-containing-monooxygenase-probe-substrate-simulated-with-pharmacokinetic-data-from-control-and-humanized-liver-mice
#18
Miho Yamazaki-Nishioka, Makiko Shimizu, Hiroshi Suemizu, Megumi Nishiwaki, Marina Mitsui, Hiroshi Yamazaki
1. Benzydamine is used clinically as a nonsteroidal anti-inflammatory drug in oral rinses and is employed in preclinical research as a flavin-containing monooxygenase (FMO) probe substrate. In this study, plasma concentrations of benzydamine and its primary N-oxide and N-demethylated metabolites were investigated in control TK-NOG mice, in humanized-liver mice, and in mice whose liver cells had been ablated with ganciclovir. 2. Following oral administration of benzydamine (10 mg/kg) in humanized-liver TK-NOG mice, plasma concentrations of benzydamine N-oxide were slightly higher than those of demethyl benzydamine...
February 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28137602/identification-of-human-flavin-containing-monooxygenase-3-substrates-by-a-colorimetric-screening-assay
#19
Gianluca Catucci, Isabelle Polignano, Debora Cusumano, Claudio Medana, Gianfranco Gilardi, Sheila J Sadeghi
Human hepatic flavin-containing monooxygenase 3 is a phase I drug-metabolizing enzyme that is responsible for the oxidation of a variety of drugs and xenobiotics. This work reports on a high throughput rapid colorimetric assay for the screening of substrates or inhibitors of this enzyme. The method is based on the competition of two substrates for access to the active site of hFMO3 whereby the enzymatic product of the first drug converts nitro-5-thiobenzoate (TNB, yellow) to 5,5'-dithiobis (2-nitrobenzoate) (DTNB, colourless)...
April 1, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28054999/interaction-between-dna-and-drugs-having-protonable-basic-groups-characterization-through-affinity-constants-drug-release-kinetics-and-conformational-changes
#20
Liliana P Alarcón, Yolima Baena, Rubén H Manzo
This paper reports the in vitro characterization of the interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups through the determination of the affinity constants, the reversibility of the interaction, and the effect on the secondary structure of the macromolecule. Affinity constants of the counterionic condensation DNA-drug were in the order of 10⁶. The negative electrokinetic potential of DNA decreased with the increase of the proportion of loading drugs. The drugs were slowly released from the DNA-drug complexes and had release kinetics consistent with the high degree of counterionic condensation...
January 4, 2017: Scientia Pharmaceutica
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