Maria Cristina Carena, Ileana Badi, Murray Polkinghorne, Ioannis Akoumianakis, Costas Psarros, Elizabeth Wahome, Christos P Kotanidis, Nadia Akawi, Alexios S Antonopoulos, Jagat Chauhan, Rana Sayeed, George Krasopoulos, Vivek Srivastava, Shakil Farid, Nicholas Walcot, Gillian Douglas, Keith M Channon, Barbara Casadei, Charalambos Antoniades
BACKGROUND: Visceral obesity is directly linked to increased cardiovascular risk, including heart failure. OBJECTIVES: This study explored the ability of human epicardial adipose tissue (EAT)-derived microRNAs (miRNAs) to regulate the myocardial redox state and clinical outcomes. METHODS: This study screened for miRNAs expressed and released from human EAT and tested for correlations with the redox state in the adjacent myocardium in paired EAT/atrial biopsy specimens from patients undergoing cardiac surgery...
July 25, 2023: Journal of the American College of Cardiology