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https://www.readbyqxmd.com/read/28690211/new-perspectives-on-dandruff-and-seborrheic-dermatitis-lessons-we-learned-from-bacterial-and-fungal-skin-microbiota
#1
Luciana Campos Paulino
The human body is inhabited by complex microbial communities, which positively impact different aspects of our health, and might also be related to the development of diseases. Progress in technologies, particularly sequencing methods and bioinformatics tools, has been crucial for the advances in this field. Microbial communities from skin can modulate immune response and protect the host against pathogens, and there are also data supporting their association with several skin conditions; including dandruff and seborrheic dermatitis...
June 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28679382/ethnopharmacological-survey-of-home-remedies-used-for-treatment-of-hair-and-scalp-and-their-methods-of-preparation-in-the-west-bank-palestine
#2
Abdel Naser Zaid, Nidal Amin Jaradat, Ahmad Mustafa Eid, Hamzeh Al Zabadi, Abdulsalam Alkaiyat, Saja Adam Darwish
BACKGROUND: Natural products have many uses and purposes, including those linked to pharmaceutics and cosmetics. The aim of this study was to investigate the use of natural remedies for the treatment of hair and scalp disorders in the West Bank, Palestine. METHODS: An ethnopharmacological survey of herbal remedies and other natural products used in cosmetics and cosmeceuticals was carried out in the West Bank, Palestine. A questionnaire was distributed to 267 herbalists, traditional healers, hairdressers and rural dwellers...
July 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28673550/a-rare-case-of-sterol-c4-methyl-oxidase-deficiency-in-a-young-italian-male-biochemical-and-molecular-characterization
#3
Giulia Frisso, Monica Gelzo, Elena Procopio, Concetta Sica, Maria Pia Lenza, Antonio Dello Russo, Maria Alice Donati, Francesco Salvatore, Gaetano Corso
Inborn defects of cholesterol biosynthesis are metabolic disorders presenting with multi-organ and tissue anomalies. An autosomal recessive defect involving the demethylating enzyme C4-methyl sterol (SC4MOL) has been reported in only 4 patients so far. In infancy, all patients were affected by microcephaly, bilateral congenital cataracts, growth delay, psoriasiform dermatitis, immune dysfunction, and intellectual disability. Herein, we describe a new case of SC4MOL deficiency in which a 19-year-old Italian male was affected by bilateral congenital cataracts, growth delay and learning disabilities, behavioral disorders and small stature, but not microcephaly...
June 27, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28599021/imaging-microscopic-distribution-of-antifungal-agents-in-dandruff-treatments-with-stimulated-raman-scattering-microscopy
#4
Natlaie L Garrett, Bhumika Singh, Andrew Jones, Julian Moger
No abstract text is available yet for this article.
June 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28566909/in-vitro-anti-malassezia-activity-of-castanea-crenata-shell-and-oil-soluble-glycyrrhiza-extracts
#5
Song Hee Han, Min Seok Hur, Min Jung Kim, Won Hee Jung, Minji Park, Jeong Hwan Kim, Hong Ju Shin, Yong Beom Choe, Kyu Joong Ahn, Yang Won Lee
BACKGROUND: A new shampoo with anti-Malassezia properties obtained from various plants is required to provide seborrheic dermatitis patients with a wider range of treatment options. OBJECTIVE: The aim of this study was to obtain in vitro susceptibility profiles of Malassezia restricta and M. globosa, the most important pathogenic organisms in the development of seborrheic dermatitis, to the plant extracts used in commercial anti-dandruff shampoos. METHODS: Minimal inhibitory concentrations (MICs) were determined for eight candidate plant extracts and two plant-derived natural products diluted with Leeming and Notman medium to final concentrations of 0...
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28552438/high-prevalence-of-demodex-spp-infestation-among-patients-with-posterior-blepharitis-correlation-with-age-and-cylindrical-dandruff
#6
D López-Ponce, F Zuazo, C Cartes, D Salinas-Toro, C Pérez-Valenzuela, F Valenzuela, L Traipe-Castro, R O López-Solís
OBJECTIVE: To determine prevalence of Demodex spp. and infestation index (II) by the parasite among patients of different ages with blepharitis and to assess association with occurrence of cylindrical dandruff (CC). MATERIALS AND METHODS: Prospective study including patients diagnosed with posterior blepharitis between 2013 and 2015, without previous acaricide treatment, was conducted by Fundación Oftalmológica Los Andes (Chile). Four eyelashes were randomly extracted from each eyelid for parasite detection...
May 25, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28550716/ex-vivo-measurement-of-scalp-follicular-infundibulum-delivery-of-zinc-pyrithione-and-climbazole-from-an-anti-dandruff-shampoo
#7
Guoqiang Chen, Chengdong Ji, Miao Miao, Kang Yang, Yajun Luo, Michael Hoptroff, Luisa Z Collins, Hans-Gerd Janssen
Efficient delivery of anti-dandruff (AD) actives into the scalp follicular infundibulum as well as onto the scalp surface is critical for the efficacy of AD shampoos. A method involving scalp cyanoacrylate (CA) biopsy sampling, a tailor made cutting device, ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analysis, scanning electron microscopy (SEM) measurement and Raman imaging has been developed for the measurement of delivery of zinc pyrithione (ZPT) and climbazole (CBZ) from an AD shampoo into the scalp follicular infundibulum...
September 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28504468/incubatory-environment-of-the-scalp-impacts-pre-emergent-hair-to-affect-post-emergent-hair-cuticle-integrity
#8
James R Schwartz, James P Henry, Kathy M Kerr, Michael J Flagler, Steve H Page, Nancy Redman-Furey
OBJECTIVES: To determine whether the oxidative stress transmitted to newly grown hair from an unhealthy scalp has physical consequences to the cuticular condition and function. METHODS: A uniquely designed 24-week clinical study included 8 weeks of pretreatment with a cosmetic shampoo and 16 weeks of treatment with either a potentiated zinc pyrithione (ZPT) antidandruff shampoo or a placebo cosmetic shampoo. This clinical design allowed the growth and acquisition of hair samples under conditions of varying but known scalp health as a result of treating a dandruff/seborrheic dermatitis (D/SD) population...
May 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28468620/evaluation-of-therapeutic-potential-of-vb-001-a-leave-on-formulation-for-the-treatment-of-moderate-adherent-dandruff
#9
Anamika Bhattacharyya, Nilu Jain, Sudhanand Prasad, Shilpi Jain, Vishal Yadav, Shamik Ghosh, Shiladitya Sengupta
BACKGROUND: Dandruff is a common scalp condition characterized by excessive scaling and itch. Aberrant colonization of the scalp by commensal Malassezia spp. is a major contributor in the multifactorial etiology of dandruff. Literature based understanding of Malassezia linked pathophysiology of dandruff allowed us to comprehend a strategy to potentiate the efficacy of a known antifungal agent used in dandruff therapy. The aim of this study was to determine the efficacy and skin safety of VB-001 antidandruff leave-on formulation in comparison with marketed antidandruff ZPTO shampoo in patients with moderate adherent dandruff of the scalp...
May 3, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28403264/a-retrospective-review-of-treatment-results-for-patients-with-central-centrifugal-cicatrical-alopecia
#10
Ariana Eginli, Emily Dothard, Courtney W Bagayoko, Karen Huang, Alyssa Daniel, Amy J McMichael
<p>INTRODUCTION: Central centrifugal cicatricial alopecia (CCCA) is a form of scarring alopecia primarily affecting women of African descent on the crown of the scalp. Limited data exists regarding evidence-based treatment for CCCA.</p> <p>OBJECTIVE: To examine photos of subjects with CCCA before and after treatment in order to evaluate results of treatment and compare results of different treatment regimens.</p> <p>METHODS: Photographs of 15 subjects with CCCA before and after treatment were evaluated by two blinded investigators who assigned disease severity scores to photographs based on a published scale: Central Scalp Alopecia Photographic Scale in African American Women...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28393697/targeting-malassezia-species-for-novel-synthetic-and-natural-antidandruff-agents
#11
Letizia Angiolella, Simone Carradori, Cristina Maccallini, Gustavo Giusiano, Claudiu T Supuran
Malassezia spp. are lipophilic yeasts not only present in the normal skin microflora, but also responsible of skin-related diseases (pityriasis versicolor, seborrheic/atopic dermatitis and dandruff) as well as systemic fungal infections in humans and animals. Their treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance and several side effects. These drawbacks have prompted the research toward novel synthetic and natural derivatives/nanomaterials targeting other pivotal enzymes/pathways such as carbonic anhydrase (MgCA) and lipases, alone or in combination, in order to improve the eradication rate of this fungus...
April 4, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28383830/-how-i-treat-%C3%A2-dandruff-using-a-shampoo-with-a-sulfate-free-tensio-active
#12
REVIEW
P Reygagne, G E Piérard, G Loussouarn, N Le Nôtre, S Ziane
A new formulation of an anti-dandruff shampoo containing a surfactant devoid of a sulfate-type anionic part has been assessed in vivo in 41 subjects. Introducing a welltried agent, the 0.5 % piroctone olamine confers to this shampoo a high anti-dandruff efficacy, a reduction in the density in Malassezia spp, as well as a good remanence after shampoo. In addition, piroctone olamine appears to influence the sebum rheology by reducing the hair greasing.
September 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28375586/a-dissociation-in-judgements-of-confidence-in-people-with-dandruff-based-on-self-reports-compared-to-reports-from-other-observers
#13
A Godbehere, L McDonald, F Baines, C A M Sutherland, T J Andrews
OBJECTIVE: It is not clear how well evaluations made by other people correspond with self-evaluations of esteem or confidence. To address this question, we compared measurements of confidence in participants with and without dandruff. METHODS: Participants with dandruff were significantly different from healthy control participants on a quality of life measure of scalp dermatitis, but not on self-evaluations of esteem or confidence. To determine whether there were differences in the evaluation of confidence by others, both groups of participants were videoed while they prepared for or gave a presentation in an interview scenario...
April 4, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28343756/inhibition-of-malassezia-globosa-carbonic-anhydrase-with-phenols
#14
Yeganeh Entezari Heravi, Silvia Bua, Alessio Nocentini, Sonia Del Prete, Ali Akbar Saboury, Hassan Sereshti, Clemente Capasso, Paola Gratteri, Claudiu T Supuran
A panel of 22 phenols was investigated as inhibitors of the β-class carbonic anhydrase (CAs, EC 4.2.1.1) from the fungal parasite Malassezia globosa (MgCA), a validated anti-dandruff drug target. The displayed inhibitory activities were compared to the ones previously reported against the off-target widely distributed human (h) isoforms hCA I and II. All tested phenols possessed a better efficacy in inhibiting MgCA than the clinically used sulfonamide acetazolamide, with KIs in the range of 2.5 and 65.0μM...
March 18, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28280911/-physiology-of-the-scalp
#15
REVIEW
R Rukwied
BACKGROUND: Human scalp reveals a remarkable difference to hairy skin of other body regions. The structure of the scalp offers effective protection against water loss and contributes to thermoregulation due to significant vascularization. The scalp is innervated by the trigeminus nerve. OBJECTIVES: The majority of the population complain about "sensitive" scalp. However, sensory, regional, ethnic or pathologic parameters contributing to "sensitive" scalp are largely unknown...
March 9, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28226316/clinical-evidence-of-increase-in-hair-growth-and-decrease-in-hair-loss-without-adverse-reactions-promoted-by-the-commercial-lotion-ecohair%C3%A2
#16
María Rosario Alonso, Claudia Anesini
BACKGROUND/AIMS: Hair exerts protection, sensory functions, thermoregulation, and sexual attractiveness. Hair loss (alopecia) is caused by several diseases, drug intake, hormone imbalance, stress, and infections (Malassesia furfur). Drugs usually used in alopecia produce irreversible systemic and local side effects. An association of extracts of Coffea arabica and Larrea divaricata (ECOHAIR®) is successfully being commercialized in Argentina for hair growth. The aim of this study was to provide scientific support for the efficacy and innocuousness of ECOHAIR® in patients with noncicatricial alopecia during a 3-month treatment...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28183164/estrogenic-activity-of-zinc-pyrithione-an-in-vivo-and-in-vitro-study
#17
Seung Jun Kwack, Kyung Sik Yoon, Nam Hee Youn, Hyun Gyung Gu
Objectives: Zinc pyrithione is commonly used to prevent dandruff and seborrheic dermatitis. Many consumers are exposed daily to high doses of zinc pyrithione, causing serious concerns about its toxicity. The reproductive and developmental toxicities were previously reported in pregnant rats. However, the estrogenic activity of zinc pyrithione at varying degrees of exposure has been rarely studied. Thus, we performed an uterotrophic assay, E-screen assay, and gene expression profiling to assess the estrogenic activity of zinc pyrithione...
February 9, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28149788/prevalence-of-ocular-demodicosis-among-patients-at-tertiary-care-center-bangkok-thailand
#18
Ngamjit Kasetsuwan, Kitchaporn Kositphipat, Mathu Busayarat, Pawanrat Threekhan, Kanok Preativatanyou, Atchara Phumee, Padet Siriyasatien
AIM: To determine the prevalence of ocular demodicosis by both microscopic examination and molecular detection among patients at King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok. METHODS: One hundred individuals were enrolled in the study and were divided into five age groups. The meibomian gland dysfunction (MGD) score and qualities of cylindrical dandruff (CD) were also determined. Demodex mite infestations of eyelash samples were screened by both microscopic examination and semi-nested polymerase chain reaction (PCR)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28149170/effectiveness-of-five-antidandruff-cosmetic-formulations-against-planktonic-cells-and-biofilms-of-dermatophytes
#19
Renan Martins Dos Santos, Marcus Vinícius Dias-Souza
This study aimed to investigate the in vitro antifungal effectiveness of five different formulations against dandruff and ringworm dermatophytes. Candida albicans was also included in our assays. Fungal susceptibility tests were performed with planktonic cells and biofilms of reference strains. Microbiological and physicochemical quality parameters were assessed for all formulations. Our data indicated that the formulations were effective against the dermatophytes strains, and to our knowledge, the effectiveness of cosmetic formulations against fungal biofilms is shown for the first time...
February 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28111598/the-mpeg-pcl-copolymer-for-selective-fermentation-of-staphylococcus-lugdunensis-against-candida-parapsilosis-in-the-human-microbiome
#20
Ming-Shan Kao, Yanhan Wang, Shinta Marito, Stephen Huang, Wan-Zhen Lin, Jon A Gangoiti, Bruce A Barshop, Choi Hyun, Woan-Ruah Lee, James A Sanford, Richard L Gallo, Yuping Ran, Wan-Tzu Chen, Chun-Jen Huang, Ming-Fa Hsieh, Chun-Ming Huang
Many human skin diseases, such as seborrheic dermatitis, potentially occur due to the over-growth of fungi. It remains a challenge to develop fungicides with a lower risk of generating resistant fungi and non-specifically killing commensal microbes. Our probiotic approaches using a selective fermentation initiator of skin commensal bacteria, fermentation metabolites or their derivatives provide novel therapeutics to rein in the over-growth of fungi. Staphylococcus lugdunensis (S. lugdunensis) bacteria and Candida parapsilosis (C...
August 2016: Journal of microbial & biochemical technology
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