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Epicardial adipose tissue

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https://www.readbyqxmd.com/read/27910111/cystatin-c-and-epicardial-adipose-tissue-as-noninvasive-predictors-of-cardiovascular-risk-in-acromegaly
#1
Anna Aulinas, Iris Crespo, David Viladés, Ruben Leta, Eulàlia Urgell, Betina Biagetti, Susan M Webb, Elena Valassi
BACKGROUND: Acromegaly (ACRO) is associated with elevated cardiovascular risk, although the prevalence of coronary artery disease (CAD) is unclear. Increased epicardial adipose tissue (EAT) and elevated cystatin-C (Cys-C) levels are cardiovascular risk factors, also related to the progression of CAD in several populations. AIMS: To measure the severity and extent of CAD in patients with ACRO and to determine whether either EAT or Cys-C reflect higher cardiovascular risk in patients with ACRO than in healthy controls...
November 7, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27903394/-correlation-between-epicardial-adipose-tissue-thickness-and-slow-flow-of-non-obstructive-coronary-artery
#2
Q Wu, B Yang
Objective: To investigate the correlation between epicardial adipose thickness and slow flow of non-obstructive coronary artery. Methods: Clinical data of patients with coronary angiography examination evidenced stenosis<50% in our department from May 2014 to May 2015 were retrospectively analyzed.According to the level of TIMI in angiography, patients were divided into slow blood flow group (TIMI Ⅰ-Ⅱ, n=16) and normal blood flow group (TIMI Ⅲ, n=127). All epicardial adipose thickness was determined by echocardiography and data of biochemical data (fibrinogen, whole blood viscosity at high shear rate, erythrocyte aggregation index, platelet count, and platelet aggregation rate) were also analyzed...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27899941/influence-of-increased-epicardial-adipose-tissue-volume-on-1-year-in-stent-restenosis-in-patients-who-received-coronary-stent-implantation
#3
Ying Zhou, Hua-Wei Zhang, Feng Tian, Jin-Song Chen, Tian-Wen Han, Ya-Hang Tan, Jia Zhou, Tao Zhang, Jing Jing, Yun-Dai Chen
BACKGROUND: Epicardial adipose tissue (EAT) is significantly associated with the formation and composition of coronary atherosclerotic plaque, cardiac events and the clinical prognosis of coronary heart disease. But, whether increased EAT deposition may affect the incidence of in-stent restenosis (ISR) is currently unclear. This study used coronary computed tomography angiography (CCTA) as a mean to investigate whether increased EAT volume was associated with ISR. METHODS: A total of 364 patients who underwent 64-slice CCTA examination for the evaluation of suspected coronary artery disease, and subsequently underwent percutaneous coronary intervention (PCI) for the first time, and then accepted coronary angiography (CA) follow-up for ISR examination in one year, were retrospectively included in this study...
September 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27888013/epicardial-adipose-tissue-in-the-general-middle-aged-population-and-its-association-with-metabolic-syndrome
#4
Álvaro Calabuig, Joaquín Barba, María Jesús Guembe, Javier Díez, Jesús Berjón, Eduardo Martínez-Vila, Pablo Irimia, Estefanía Toledo
INTRODUCTION AND OBJECTIVES: There is currently increasing interest in epicardial adipose tissue (EAT) as a marker of cardiovascular disease. Our purpose was to describe EAT, measured by transthoracic echocardiography, and to assess its association with metabolic syndrome (MS) in the RIVANA population-based study. METHODS: Physical examination was performed in 880 participants aged 45 to 74 years (492 of them with MS according to the harmonized definition). Fasting glucose, high-density lipoprotein cholesterol, triglyceride, and C-reactive protein concentrations were determined in a blood sample...
November 22, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27882550/investigating-interactions-between-epicardial-adipose-tissue-and-cardiac-myocytes-what-can-we-learn-from-different-approaches
#5
REVIEW
Katja Rietdorf, Hilary MacQueen
Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological interventions for their management. More targeted and less invasive therapies would be beneficial. Recently it has become apparent that epicardial adipose tissue plays an important role in normal and pathological cardiac function, and it is now the focus of considerable research...
November 24, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27878751/assessment-of-the-relationship-between-serum-paraoxonase-activity-and-epicardial-adipose-tissue-in-hemodialysis-patients
#6
Emad Abdallah, Samya El-Shishtawy, Nevine Sherif, Ahmed Ali, Omnia El-Bendary
PURPOSE: Paraoxonase-1 (PON-1) is a high-density lipoprotein-associated (HDL) enzyme, which has been shown to reduce susceptibility to low-density lipoprotein (LDL) peroxidation. Epicardial adipose tissue (EAT) is a marker of atherosclerosis. The aim of this study was to determine the relationship between PON-1 activity and EAT in hemodialysis (HD) patients. METHODS: This is a cross-sectional study conducted on 72 (43 males) HD patients with end-stage renal disease...
November 23, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27875723/orosomucoid-as-prognosis-factor-associated-with-inflammation-in-acute-or-nutritional-status-in-chronic-heart-failure
#7
Rosa M Agra, Alfonso Varela-Román, Rocío González-Ferreiro, Juan E Viñuela, Ana Castro-Pais, Ángel Fernández-Trasancos, Esther Díaz-Rodríguez, Ezequiel Álvarez, Marcos C Carreira, Felipe F Casanueva, José R González-Juanatey, Sonia Eiras
BACKGROUND: Inflammation and nutritional state are involved in the pathogenesis of heart failure (HF). OBJECTIVE: To study the contribution of alpha-1-acid-glycoprotein (AGP) to these factors and its prognostic value in acute (AHF) or chronic HF (CHF). METHODS: The observational study has included 147 patients (mean age 70years, 62% men) admitted to a cardiology department for HF and followed-up for an average 326.6±140.8days. Blood AGP values were measured by Enzyme-Linked ImmunoSorbent Assay...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27872327/relation-between-cardiovascular-disease-risk-factors-and-epicardial-adipose-tissue-density-on-cardiac-computed-tomography-in-patients-at-high-risk-of-cardiovascular-events
#8
Bas T Franssens, Hendrik M Nathoe, Tim Leiner, Yolanda van der Graaf, Frank Lj Visseren
BACKGROUND: The radiodensity of epicardial adipose tissue may provide information on cardiovascular risk in addition to epicardial adipose tissue volume. The aim of this study was to quantify the relation between cardiovascular risk factors and the radiodensity of epicardial adipose tissue in patients at high risk of cardiovascular disease. DESIGN: This was a cross-sectional study in 140 patients at high risk of cardiovascular disease. METHODS: Patients from the Secondary Manifestations of ARTerial disease (SMART) cohort study were invited to undergo cardiac computed tomography angiography...
November 21, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27871080/the-association-between-premature-adrenarche-and-cardiovascular-risk-may-be-greater-than-expected
#9
Nurullah Çelik, Hayrullah Alp, Emine Çamtosun, Esma Alp, Sibel Çelik, Erhan Berk
AIM: The aim of this study was to investigate the cardiovascular risk of children with premature adrenarche (PA). METHODS: A total of 75 children (44 with PA and 31 control subjects) aged 6-10 years were included in the study. Their metabolic, anthropometric, and echocardiographic parameters were recorded and compared. RESULTS: Triglyceride, DHEA-SO4, and 17-hydroxyprogesterone levels were significantly higher in the PA group (p = 0.04, p = 0...
November 22, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27864612/secretory-products-from-epicardial-adipose-tissue-from-patients-with-type-2-diabetes-impair-mitochondrial-%C3%AE-oxidation-in-cardiomyocytes-via-activation-of-the-cardiac-renin-angiotensin-system-and-induction-of-mir-208a
#10
Marcel Blumensatt, Pia Fahlbusch, Rebecca Hilgers, Marlies Bekaert, Daniella Herzfeld de Wiza, Payam Akhyari, Johannes B Ruige, D Margriet Ouwens
Secretory products from epicardial adipose tissue (EAT) from patients with type 2 diabetes (T2D) impair cardiomyocyte function. These changes associate with alterations in miRNA expression, including the induction of miR-208a. Recent studies suggest that activation of the cardiac-specific renin-angiotensin system (RAS) may affect cardiac energy metabolism via induction of miR-208a. This study investigated whether cardiomyocyte dysfunction induced by conditioned media (CM) from EAT-T2D involves activation of the RAS/miR-208a pathway...
January 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/27864479/epicardial-adipose-tissue-and-cardiovascular-outcome-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention
#11
Maximilian Tscharre, Christina Hauser, Miklos Rohla, Matthias K Freynhofer, Johann Wojta, Kurt Huber, Thomas W Weiss
AIMS: We investigated the association between epicardial adipose tissue (EAT) thickness and cardiovascular outcomes in a cohort of high-risk patients with acute coronary syndrome undergoing percutaneous coronary intervention. METHODS: Of 1198 patients undergoing percutaneous coronary intervention, transthoracic echocardiography was performed in 438 patients during the index hospitalization. EAT thickness was measured in the parasternal long-axis view perpendicularly on the free wall of the right ventricle at end-systole in three consecutive cardiac cycles and then averaged...
November 18, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/27852304/echocardiographic-epicardial-fat-thickness-is-a-predictor-for-target-vessel-revascularization-in-patients-with-st-elevation-myocardial-infarction
#12
Jin-Sun Park, You-Hong Lee, Kyoung-Woo Seo, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk, Joon-Han Shin
BACKGROUND: The amount of epicardial adipose tissue (EAT) has been demonstrated to correlate with the severity of coronary artery disease (CAD) and the CAD activity. The aim of this study is to assess the impact of EAT on long term clinical outcomes in patients with ST elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). METHODS: We analyzed the data and clinical outcomes of 761 patients (614 males, 57 ± 12 year-old) with STEMI who underwent successful primary PCI from 2003 to 2009...
November 16, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27816807/tobacco-smoking-and-cytokine-levels-in-human-epicardial-adipose-tissue-impact-of-smoking-cessation
#13
Lukas Mach, Helena Bedanova, Miroslav Soucek, Michal Karpisek, Petr Nemec, Marek Orban
BACKGROUND & AIMS: Epicardial adipose tissue (EAT) is a source of a number of cytokines which could act in the pathogenesis of coronary artery disease (CAD). The potential relationship between known cardiovascular risk factors, such as smoking, dyslipidaemia or diabetes mellitus and EAT humoral signalling, has not been fully elucidated. Therefore, we designed and conducted a cross-sectional study to determine whether selected cardiovascular risk factors are linked to levels of cytokines in epicardial and subcutaneous adipose tissue (SAT)...
October 13, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27816522/soluble-cd14-inhibits-contractile-function-and-insulin-action-in-primary-adult-rat-cardiomyocytes
#14
Sabrina Overhagen, Marcel Blumensatt, Pia Fahlbusch, Daniella Herzfeld de Wiza, Heidi Müller, Bujar Maxhera, Payam Akhyari, D Margriet Ouwens
Epicardial adipose tissue (EAT) from patients with type 2 diabetes (T2D) is characterized by monocyte infiltrations and displays an elevated release of the monocyte marker soluble cluster of differentiation 14 (sCD14) versus EAT from patients without T2D. We propose that an increased abundance of sCD14 in EAT from patients with T2D may impair the function and insulin sensitivity of the adjacent cardiomyocytes. To examine this, primary adult rat cardiomyocytes were incubated with increasing concentrations of sCD14 in the presence and absence of the co-receptor lipopolysaccharide (LPS), and analyzed for effects on determinants of contractile function, activation of inflammation signalling and insulin action...
November 3, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27803039/an-igf1r-dependent-pathway-drives-epicardial-adipose-tissue-formation-after-myocardial-injury
#15
Lior Zangi, Marcela S Oliveira, Lillian Y Ye, Qing Ma, Nishat Sultana, Yoav Hadas, Elena Chepurko, Daniela Später, Bin Zhou, Wei Leong Chew, Wataru Ebina, Maryline Abrial, Qing-Dong Wang, William T Pu, Kenneth R Chien
BACKGROUND: -Epicardial adipose tissue (EAT) volume and coronary artery disease are strongly associated, even after accounting for overall body mass. Despite its pathophysiological significance, the origin and paracrine signaling pathways that regulate EAT's formation and expansion are unclear. METHODS: -We used a novel modified mRNA (modRNA)-based screening approach to probe the effect of individual paracrine factors on epicardial progenitors in the adult heart...
November 1, 2016: Circulation
https://www.readbyqxmd.com/read/27798236/lamin-b1-contributes-to-the-proper-timing-of-epicardial-cell-migration-and-function-during-embryonic-heart-development
#16
Joseph R Tran, Xiaobin Zheng, Yixian Zheng
Lamin proteins form a meshwork beneath the nuclear envelope and contribute to many different cellular processes. Mutations in lamins cause defective organogenesis in mouse models and human diseases that affect adipose, brain, skeletal muscle, and the heart. In vitro cell culture studies have shown that lamins help maintain nuclear shape and facilitate cell migration. However, whether these defects contribute to improper tissue building in vivo requires further clarification. By studying the heart epicardium during embryogenesis, we show that Lb1 null epicardial cells exhibit an in vivo and in vitro migratory delay...
October 19, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27790354/assosiation-of-epicardial-and-pericardial-fat-thickness-with-coronary-artery-disease
#17
Fereshteh Ghaderi, Ali Eshraghi, Alireza Sepehri Shamloo, Sareh Mousavi
INTRODUCTION: Visceral adipose tissue is a known important risk factor for coronary artery disease (CAD). While some studies have suggested relationship between epicardial fat thickness (EFT) and CAD, there are no adequate studies for pericardial fat thickness (PFT). The aim of this study was to determine the association of EFT and PFT with CAD. METHODS: This cross-sectional study was conducted on patients who were candidates for elective coronary artery angiography, referred to Emam Reza Hospital, Mashhad, Iran during Jan 2014-2016...
September 2016: Electronic Physician
https://www.readbyqxmd.com/read/27781958/metalloproteinases-activity-in-epicardial-adipose-tissue-of-patients-with-coronary-artery-disease
#18
Gabriela Berg, Verónica Miksztowicz, Celina Morales, Magalí Barchuk, Graciela López, Ricardo Póveda, Ricardo Gelpi, Laura Schreier, Miguel Rubio
BACKGROUND: Epicardial adipose tissue (EAT) is a visceral adipose tissue (AT) surrounding and infiltrating myocardium and coronary arteries. Increased EAT may represent a chronic inflammatory injury and represent a link with coronary artery disease (CAD). Metalloproteinases (MMPs) are involved in expansion of AT. OBJECTIVE: to evaluate MMP-2 and -9 behavior in EAT from coronary artery disease patients. METHODS: In EAT and subcutaneous AT (SAT) from patients undergoing coronary artery bypass graft (CABG, n=30) or valve replacement (No CABG, n=18), MMP-2 and -9 activity and localization, inflammatory cells and vascular endothelial growth factor (VEGF) levels were determined...
October 24, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27754052/os-14-09-epicardial-fat-thickness-and-neutrophil-to-lymphocyte-ratio-are-increased-in-the-non-dipper-pattern
#19
Kyoung Im Cho, Jung Ho Heo, Hyun Soo Kim, Sung Il Im, Tae Joon Cha
OBJECTIVE: Epicardial fat tissue reflects visceral adiposity and inflammation, and neutrophil to lymphocyte ratio (NLR) has been investigated as important inflammatory marker in cardiovascular disease. We aimed to investigate the relationship of echocardiographic epicardial fat thickness (EFT) and NLR with diurnal blood pressure (BP) changes in patients with recently diagnosed essential hypertension. DESIGN AND METHOD: A total of 647 hypertensive patients underwent echocardiography and 24-hours ambulatory BP monitoring...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27733727/epicardial-adipose-tissue-as-a-predictor-for-the-development-of-non-calcified-coronary-plaque
#20
Koichi Kaikita
No abstract text is available yet for this article.
October 12, 2016: Journal of Atherosclerosis and Thrombosis
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