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Epicardial adipose tissue

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https://www.readbyqxmd.com/read/28296956/equifat-a-novel-scoring-system-for-the-semi-quantitative-evaluation-of-regional-adipose-tissues-in-equidae
#1
Philippa K Morrison, Patricia A Harris, Charlotte A Maltin, Dai Grove-White, Caroline McG Argo
Anatomically distinct adipose tissues represent variable risks to metabolic health in man and some other mammals. Quantitative-imaging of internal adipose depots is problematic in large animals and associations between regional adiposity and health are poorly understood. This study aimed to develop and test a semi-quantitative system (EQUIFAT) which could be applied to regional adipose tissues. Anatomically-defined, photographic images of adipose depots (omental, mesenteric, epicardial, rump) were collected from 38 animals immediately post-mortem...
2017: PloS One
https://www.readbyqxmd.com/read/28279438/relation-of-epicardial-adipose-tissue-radiodensity-to-coronary-artery-calcium-on-cardiac-computed-tomography-in-patients-at-high-risk-for-cardiovascular-disease
#2
Bas T Franssens, Hendrik M Nathoe, Frank L J Visseren, Yolanda van der Graaf, Tim Leiner
Adipose tissue radiodensity detected by computed tomography (CT) is hypothesized to be associated with differences in adipose tissue composition which may contribute to the development of coronary atherosclerosis independent of epicardial adipose tissue volume. The aim of the present study is to quantify the relation between epicardial adipose tissue radiodensity and presence, distribution, and density of coronary artery calcium (CAC) in patients at high risk for cardiovascular disease. A total of 140 patients of the Secondary Manifestations of ARTerial disease (SMART) study underwent cardiac-CT angiography...
February 11, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28268083/epicardial-adipose-tissue-microbial-colonization-and-inflammasome-activation-in-acute-coronary-syndrome
#3
Daniela Pedicino, Anna Severino, Sara Ucci, Francesca Bugli, Davide Flego, Ada F Giglio, Francesco Trotta, Aureliano Ruggio, Claudia Lucci, Antonio Iaconelli, Francesco Paroni Sterbini, Luigi M Biasucci, Maurizio Sanguinetti, Franco Glieca, Nicola Luciani, Massimo Massetti, Filippo Crea, Giovanna Liuzzo
BACKGROUND: Epicardial adipose tissue (EAT) has a close functional and anatomic relationship with epicardial coronary arteries. Accumulating evidence suggests that host microbiome alterations may play a role in several inflammatory/immune disorders, triggering a robust proinflammatory response also involving interleukin-1β (IL-1β) and the NALP3 inflammasome. In the current study, we explore the hypothesis that in patients with non-ST elevation acute coronary syndrome (ACS), EAT contains potentially pro-atherosclerotic bacteria that might elicit inflammasome activation...
February 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28261292/epicardial-fat-thickness-and-oxidative-stress-parameters-in-patients-with-subclinical-hypothyroidism
#4
Ali Aydogdu, Emel Yigit Karakas, Emre Erkus, İbrahim Halil Altıparmak, Emin Savık, Turgay Ulas, Tevfik Sabuncu
INTRODUCTION: Thyroid disorders are known to be a risk factor for cardiovascular diseases. Epicardial fat thickness (EFT) and oxidative stress are also believed to be major risk factors for cardiovascular events. The aim of this study was to evaluate the possible relationship between oxidative stress parameters and EFT in patients with subclinical hypothyroidism (SCH). MATERIAL AND METHODS: A total of 60 individuals (30 patients with SCH and 30 healthy controls) were recruited for the study...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28256566/aberrant-epicardial-adipose-tissue-extracellular-matrix-remodeling-in-patients-with-severe-ischemic-cardiomyopathy-insight-from-comparative-quantitative-proteomics
#5
Ding-Sheng Jiang, Hao-Long Zeng, Rui Li, Bo Huo, Yun-Shu Su, Jing Fang, Qing Yang, Li-Gang Liu, Min Hu, Cai Cheng, Xue-Hai Zhu, Xin Yi, Xiang Wei
There is ample evidence indicating that epicardial adipose tissue (EAT) volume and thickness is positively associated with coronary artery disease (CAD). However, the exact pathological changes in the human EAT after myocardial ischemia remains largely unclear. In the current study, we applied a comparative quantitative proteomics to elucidate the altered biological processes in the EAT of ischemic cardiomyopathy (ICM) patients. A total of 1649 proteins were successfully quantified in our study, among which 165 proteins were significantly changed (ratio <0...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229226/pericoronary-adipose-tissue-ratio-is-a-stronger-associated-factor-of-plaque-vulnerability-than-epicardial-adipose-tissue-on-coronary-computed-tomography-angiography
#6
Ryo Okubo, Rine Nakanishi, Mikihito Toda, Daiga Saito, Ippei Watanabe, Takayuki Yabe, Hideo Amano, Tatsushi Hirai, Takanori Ikeda
This study was designed to clarify the influence of pericoronary adipose tissue (PAT) on plaque vulnerability using coronary computed tomography angiography (CCTA). A total of 103 consecutive patients who underwent CCTA and subsequent percutaneous coronary intervention (PCI) using intravascular ultrasound (IVUS) for coronary artery disease were enrolled. The PAT ratio was calculated as the sum of the perpendicular thickness of the visceral layer between the coronary artery and the pericardium, or the coronary artery and the surface of the heart at the PCI site, divided by the PAT thickness without a plaque in the same vessel...
February 22, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28223054/epicardial-adipose-tissue-removal-potentiates-outward-remodeling-and-arrests-coronary-atherogenesis
#7
Mikaela L McKenney-Drake, Stacey D Rodenbeck, Rebecca S Bruning, Ayeeshik Kole, Kyle W Yancey, Mouhamad Alloosh, Harold S Sacks, Michael Sturek
BACKGROUND: Pericoronary epicardial adipose tissue (cEAT) serves as a metabolic and paracrine organ that contributes to inflammation and is associated with macrovascular coronary artery disease (CAD) development. Although there is a strong correlation in humans between cEAT volume and CAD severity, there remains a paucity of experimental data demonstrating a causal link of cEAT to CAD. The current study tested the hypothesis that surgical resection of cEAT attenuates inflammation and CAD progression...
February 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28191635/the-role-of-epicardial-adipose-tissue-in-cardiac-biology-classic-concepts-and-emerging-roles
#8
Alexios S Antonopoulos, Charalambos Antoniades
Classic concepts about the role of epicardial adipose tissue (EpAT) in heart physiology include its role in cardiac metabolism, the mechanical protection of coronaries, the innervation and possibly cryoprotection of the heart too. Nevertheless, recent evidence has revealed that epicardial adipose tissue regulates multiple aspects of cardiac biology including myocardial redox state, intracellular Ca(2+) cycling, the electrophysiological (EP) and contractile properties of cardiomyocytes, cardiac fibrosis as well as coronary atherosclerosis progression...
February 12, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28183844/association-between-posterior-left-atrial-adipose-tissue-mass-and-atrial-fibrillation
#9
Alexander R van Rosendael, Aukelien C Dimitriu-Leen, Philippe J van Rosendael, Melissa Leung, Jeff M Smit, Antti Saraste, Juhani Knuuti, Rob J van der Geest, Britt W H van der Arend, Erik W van Zwet, Arthur J Scholte, Victoria Delgado, Jeroen J Bax
BACKGROUND: Epicardial adipose tissue located close to the atrial wall can change the electric conduction of the left atrium, potentially leading to atrial fibrillation (AF). The aim of this study was to assess whether an increased atrial adipose tissue mass posterior to the left atrium is related to AF independent of demographical and cardiovascular risk factors. METHODS AND RESULTS: Two hundred patients with AF and 200 patients without AF who underwent computed tomographic angiography were included...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28160962/increased-serum-renalase-in-peritoneal-dialysis-patients-is-it-related-to-cardiovascular-disease-risk
#10
Ebru Gok Oguz, Hadim Akoglu, Gulay Ulusal Okyay, Guner Karaveli Gursoy, Tolga Yildirim, Ozgur Merhametsiz, Tolga Cimen, Basol Canbakan, Ekrem Yeter, M Deniz Ayli
BACKGROUND: Renalase, with possible monoamine oxidase activity, is implicated in degradation of catecholamines; which suggests novel mechanisms of cardiovascular complications in patients with chronic kidney diseases. Epicardial adipose tissue (EAT) has been found to correlate with cardiovascular diseases (CVD) in dialysis patients. The present study aimed to evaluate the association of serum renalase levels with EAT thickness and other CVD risk factors in peritoneal dialysis (PD) patients...
February 1, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28155592/impact-of-cardiopulmonary-bypass-surgery-on-cytokines-in-epicardial-adipose-tissue-comparison-with-subcutaneous-fat
#11
Lukas Mach, Helena Bedanova, Miroslav Soucek, Michal Karpisek, Tomas Konecny, Petr Nemec, Marek Orban
BACKGROUND: Cardiac surgery and cardiopulmonary bypass (CPB) have been shown to stimulate a systemic inflammatory response which has been associated with adverse postoperative outcomes. Adipose tissue, both epicardial (EAT) and subcutaneous (SAT), is a known source of inflammatory cytokines, but its role in the pathophysiology of surgery- and CPB-induced systemic inflammatory response has not been fully elucidated. Therefore, we conducted a study to establish levels of selected cytokines in EAT and SAT prior to and after surgery with CPB...
December 1, 2016: Perfusion
https://www.readbyqxmd.com/read/28144387/from-the-liver-to-the-heart-cardiac-dysfunction-in-obese-children-with-non-alcoholic-fatty-liver-disease
#12
EDITORIAL
Anna Di Sessa, Giuseppina Rosaria Umano, Emanuele Miraglia Del Giudice, Nicola Santoro
In the last decades the prevalence of non-alcoholic fatty liver disease (NAFLD) has increased as a consequence of the childhood obesity world epidemic. The liver damage occurring in NAFLD ranges from simple steatosis to steatohepatitis, fibrosis and cirrhosis. Recent findings reported that fatty liver disease is related to early atherosclerosis and cardiac dysfunction even in the pediatric population. Moreover, some authors have shown an association between liver steatosis and cardiac abnormalities, including rise in left ventricular mass, systolic and diastolic dysfunction and epicardial adipose tissue thickness...
January 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28144263/neutrophil-to-lymphocyte-ratio-as-a-possible-indicator-of-epicardial-adipose-tissue-in-patients-undergoing-hemodialysis
#13
Adalet Ozcicek, Fatih Ozcicek, Gursel Yildiz, Aysu Timuroglu, Levent Demirtas, Mutlu Buyuklu, Ufuk Kuyrukluyildiz, Emin Murat Akbas, Ergun Topal, Kultigin Turkmen
INTRODUCTION: Chronic inflammation is a major risk factor in the pathogenesis of cardiovascular disease in end-stage renal disease (ESRD) patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT was shown in healthy subjects and ESRD patients. In the present study we aimed to investigate the relationship between EAT and inflammation parameters including neutrophil-to-lymphocyte ratio (NLR) in hemodialysis (HD) patients...
February 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28137715/postmenopausal-women-with-greater-paracardial-fat-have-more-coronary-artery-calcification-than-premenopausal-women-the-study-of-women-s-health-across-the-nation-swan-cardiovascular-fat-ancillary-study
#14
Samar R El Khoudary, Kelly J Shields, Imke Janssen, Matthew J Budoff, Susan A Everson-Rose, Lynda H Powell, Karen A Matthews
BACKGROUND: Volumes of paracardial adipose tissue (PAT) and epicardial adipose tissue (EAT) are greater after menopause. Interestingly, PAT but not EAT is associated with estradiol decline, suggesting a potential role of menopause in PAT accumulation. We assessed whether volumes of heart fat depot (EAT and PAT) were associated with coronary artery calcification (CAC) in women at midlife and whether these associations were modified by menopausal status and estradiol levels. METHODS AND RESULTS: EAT and PAT volumes and CAC were measured using electron beam computed tomography scans...
January 29, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28124603/epicardial-adipose-tissue-another-tassel-in-the-complex-fabric-of-atherosclerosis
#15
Nikolaos Alexopoulos, Paolo Raggi
Atherosclerosis affects the majority of adult individuals in industrialized nations and it is beginning to affect even traditionally spared populations. The classic view has been that the precipitating events are intraluminal. However, good evidence supports the possibility that at least part of the atherosclerosis burden may be the consequence of extra-luminal noxious stimuli. Additionally, the epidemic of obesity, insulin resistance and diabetes mellitus has generated a strong interest in the potential role of visceral adipose tissue as an extra-luminal promoter of atherosclerosis...
January 24, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28124506/liraglutide-causes-large-and-rapid-epicardial-fat-reduction
#16
Gianluca Iacobellis, Mahshid Mohseni, Suzy D Bianco, Pritisheel K Banga
OBJECTIVE: Epicardial adipose tissue (EAT), the visceral fat depot of the heart, is a modifiable cardiovascular risk factor and emerging therapeutic target. Liraglutide, an analog of glucagon-like peptide-1, is indicated for the treatment of type 2 diabetes mellitus. Liraglutide has recently been shown to reduce cardiovascular risk. Nevertheless, whether liraglutide could reduce EAT is unknown. METHODS: To test the hypothesis, a 6-month randomized, open-label, controlled study was performed in 95 type 2 diabetic subjects with body mass index (BMI) ≥27 kg/m(2) and hemoglobinA1c ≤8% on metformin monotherapy...
February 2017: Obesity
https://www.readbyqxmd.com/read/28117619/looking-beyond-ectopic-fat-amount-a-smart-method-to-quantify-epicardial-adipose-tissue-density
#17
Bénédicte Gaborit, Anne Dutour
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28116519/medium-chain-fatty-acids-modulate-myocardial-function-via-a-cardiac-odorant-receptor
#18
Nikolina Jovancevic, A Dendorfer, M Matzkies, M Kovarova, J C Heckmann, M Osterloh, M Boehm, L Weber, F Nguemo, J Semmler, J Hescheler, H Milting, E Schleicher, L Gelis, H Hatt
Several studies have demonstrated the expression of odorant receptors (OR) in various human tissues and their involvement in different physiological and pathophysiological processes. However, the functional role of ORs in the human heart is still unclear. Here, we firstly report the functional characterization of an OR in the human heart. Initial next-generation sequencing analysis revealed the OR expression pattern in the adult and fetal human heart and identified the fatty acid-sensing OR51E1 as the most highly expressed OR in both cardiac development stages...
March 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28115810/epicardial-adiposity-is-associated-with-microalbuminuria-in-patients-with-essential-hypertension
#19
Mujgan Tek Ozturk, Fatma Ayerden Ebinç, Gülay Ulusal Okyay, Aysun Akbal Kutlugün
BACKGROUND: Measurement of epicardial adipose tissue (EAT) is suggested as a novel cardiometabolic risk factor. Microalbuminuria is a marker of endothelial dysfunction and is associated with an increased risk for cardiovascular disease in patients with systemic hypertension. The aim of this study was to investigate the relationship of echocardiographic epicardial adipose tissue (EAT) thickness and microalbuminuria in hypertensive patients. METHODS: 75 essential hypertensive patients were included into the study...
January 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28096344/atrial-natriuretic-peptide-regulates-adipose-tissue-accumulation-in-adult-atria
#20
Nadine Suffee, Thomas Moore-Morris, Patrick Farahmand, Catherine Rücker-Martin, Gilles Dilanian, Magali Fradet, Daigo Sawaki, Geneviève Derumeaux, Pascal LePrince, Karine Clément, Isabelle Dugail, Michel Puceat, Stéphane N Hatem
The abundance of epicardial adipose tissue (EAT) is associated with atrial fibrillation (AF), the most frequent cardiac arrhythmia. However, both the origin and the factors involved in EAT expansion are unknown. Here, we found that adult human atrial epicardial cells were highly adipogenic through an epithelial-mesenchymal transition both in vitro and in vivo. In a genetic lineage tracing the WT1(CreERT2+/-)Rosa(tdT+/-) mouse model subjected to a high-fat diet, adipocytes of atrial EAT derived from a subset of epicardial progenitors...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
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