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Epicardial adipose tissue

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https://www.readbyqxmd.com/read/28931782/tumor-necrosis-factor-%C3%AE-gene-expression-in-epicardial-adipose-tissue-is-related-to-coronary-atherosclerosis-assessed-by-computed-tomography
#1
Toshiro Kitagawa, Hideya Yamamoto, Takuya Hattori, Kazuhiro Sentani, Shinya Takahashi, Atsuhiro Senoo, Yumiko Kubo, Wataru Yasui, Taijiro Sueda, Yasuki Kihara
AIMS: Tumor necrosis factor (TNF)-α reportedly has key pro-inflammatory properties in both atherosclerosis and adipocytes. To further investigate the biologic impact of epicardial adipose tissue (EAT) on coronary atherosclerosis, we evaluated the relationship between TNF-α gene expression in EAT and clinically-assessed coronary atherosclerosis on computed tomography (CT). METHODS: We studied 47 patients before cardiac surgery (coronary artery bypass grafting [CABG], n=26; non-CABG, n=21), assessing visceral adipose tissue (VAT) area, EAT volume, coronary calcium score (CCS), and the presence of non- and/or partially-calcified coronary plaque (NCP) on CT angiography...
September 20, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28930079/epicardial-adipose-tissue-volume-and-cardiovascular-risk-indices-among-asymptomatic-women-with-and-without-hiv
#2
Suman Srinivasa, Michael T Lu, Kathleen V Fitch, Travis R Hallett, Timothy K O'Malley, Lauren A Stone, Amanda Martin, Alexandra J Coromilas, Tricia H Burdo, Virginia A Triant, Janet Lo, Sara E Looby, Tomas G Neilan, Markella V Zanni
BACKGROUND: Mechanisms underlying the heightened myocardial infarction risk among HIV-infected women (versus non-HIV-infected women) remain unclear. Our objectives were to assess epicardial adipose tissue (EAT) volume and its associations among asymptomatic women with and without HIV. METHODS: Fifty-five HIV-infected and 27 non-HIV-infected women without known cardiovascular disease who underwent cardiac CT and metabolic/immune phenotyping were included. EAT volume derived from CT was compared among women with and without HIV, and within-group EAT associations were assessed...
September 20, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28922364/association-of-epicardial-adipose-tissue-with-serum-level-of-cystatin-c-in-type-2-diabetes
#3
Tomomi Murai, Noriko Takebe, Kan Nagasawa, Yusuke Todate, Riyuki Nakagawa, Rieko Nakano, Mari Hangai, Yutaka Hasegawa, Yoshihiko Takahashi, Kunihiro Yoshioka, Yasushi Ishigaki
OBJECTIVE: Accumulation of epicardial adipose tissue (EAT) is considered to be a cardiovascular risk factor independent from visceral adiposity, obesity, hypertension and diabetes. We explored the parameters related to EAT accumulation, aiming to clarify the novel pathophysiological roles of EAT in subjects with type 2 diabetes (T2DM). METHODS: We examined the laboratory values, including cystatinC, and surrogate markers used for evaluating atherosclerosis. EAT was measured as the sum of the adipose tissue area, obtained by plain computed tomography scans in 208 subjects with T2DM but no history of coronary artery disease...
2017: PloS One
https://www.readbyqxmd.com/read/28919601/relationship-between-echocardiographic-epicardial-adipose-tissue-eat-thickness-and-angiographically-detected-coronary-artery-disease
#4
G R Bhuiyan, G C Roy, M A Siddique, M Rahman, K Ahmed, F Nahar
Epicardial adipose tissue (EAT) is a particular form of visceral adipose tissue deposited around the heart and there is growing evidence about the physiological and metabolic importance of EAT, especially in the association of cardiovascular risk profiles and the pathogenesis of atherosclerotic coronary artery disease. This observational, cross sectional study was done to determine the relationship between echocardiographic epicardial adipose tissue (EAT) thickness and coronary artery disease (CAD). Total 123 patients with established or suspected coronary artery disease admitted for coronary angiogram in the department of Cardiology of Bangabandhu Sheikh Mujib Medical University (BSMMU) from November 2010 to the end of April 2011 were included in this study...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28914752/ct-attenuation-of-pericoronary-adipose-tissue-in-normal-versus-atherosclerotic-coronary-segments-as-defined-by-intravascular-ultrasound
#5
Mohamed Marwan, Michaela Hell, Annika Schuhbäck, Sören Gauss, Daniel Bittner, Tobias Pflederer, Stephan Achenbach
BACKGROUND: The factors influencing genesis of atherosclerosis at specific regions within the coronary arterial system are currently uncertain. Local mechanical factors such as shear stress as well as metabolic factors, including inflammatory mediators released from epicardial fat, have been proposed. We analyzed computed tomographic (CT) attenuation of pericoronary adipose tissue in normal versus atherosclerotic coronary segments as defined by intravascular ultrasound (IVUS). PATIENTS AND METHODS: We evaluated the data sets of 29 patients who were referred for invasive coronary angiography and in whom IVUS of 1 coronary vessel was performed for clinical reasons...
September 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28895502/characterization-of-the-epicardial-adipose-tissue-in-decellularized-human-scaled-whole-hearts-implications-for-the-whole-heart-tissue-engineering
#6
Payam Akhyari, Fabian Oberle, Joern Huelsmann, Hans Heid, Stefan Lehr, Andreas Barbian, Sentaro Nakanishi, Hug Aubin, Alexander Jenke, Artur Lichtenberg
Whole-organ engineering is an innovative field of regenerative medicine with growing translational perspectives. Recent reports suggest the feasibility of decellularization and repopulation of entire human size hearts. However, little is known about the susceptibility of epicardial adipose tissue (EAT) to decellularization. Here, human size hearts of ovine donors were subjected to perfusion-based decellularization using detergent solutions. Upon basic histological evaluation and total DNA measurement myocardial regions prove largely decellularized while EAT demonstrated cellular remnants, further confirmed by transmission electron microscopy...
September 12, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28877159/association-between-25-hydroxyvitamin-d-and-epicardial-adipose-tissue-in-chinese-non-obese-patients-with-type-2-diabetes
#7
Xiong Chen, Wenjun Wu, Luyin Wang, Yujuan Shi, Feixia Shen, Xuemei Gu, Zhijun Jia
BACKGROUND Epicardial adipose tissue (EAT) is recognized as a useful indicator for type 2 diabetes mellitus (T2DM) and obesity. However, studies on the association between vitamin D status and EAT thickness in type 2 diabetes (T2D) are limited. In this study, we aimed to evaluate the association of vitamin D (Calcifediol) status and EAT thickness (EATT) in Chinese non-obese patients with T2D. MATERIAL AND METHODS A cross-sectional study was performed among 167 non-obese T2D Chinese patients and 82 non-diabetic patients, who are age- and gender-matched during the winter months...
September 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28868898/the-tumour-suppressor-cdkn2a-p16-ink4a-regulates-adipogenesis-and-bone-marrow-dependent-development-of-perivascular-adipose-tissue
#8
Kristiaan Wouters, Yann Deleye, Sarah A Hannou, Jonathan Vanhoutte, Xavier Maréchal, Augustin Coisne, Madjid Tagzirt, Bruno Derudas, Emmanuel Bouchaert, Christian Duhem, Emmanuelle Vallez, Casper G Schalkwijk, François Pattou, David Montaigne, Bart Staels, Réjane Paumelle
The genomic CDKN2A/B locus, encoding p16(INK4a) among others, is linked to an increased risk for cardiovascular disease and type 2 diabetes. Obesity is a risk factor for both cardiovascular disease and type 2 diabetes. p16(INK4a) is a cell cycle regulator and tumour suppressor. Whether it plays a role in adipose tissue formation is unknown. p16(INK4a) knock-down in 3T3/L1 preadipocytes or p16(INK4a) deficiency in mouse embryonic fibroblasts enhanced adipogenesis, suggesting a role for p16(INK4a) in adipose tissue formation...
September 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28856556/association-between-echocardiographic-epicardial-adipose-tissue-and-e-e-ratio-in-obese-adults
#9
Leire Moreno-Galdós, Joaquín Barba-Cosials, Jorge M Núñez-Córdoba
No abstract text is available yet for this article.
August 30, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28852208/assessing-genetic-and-environmental-influences-on-epicardial-and-abdominal-adipose-tissue-quantities-a-classical-twin-study
#10
A L Jermendy, M Kolossvary, Z D Drobni, A D Tarnoki, D L Tarnoki, J Karady, S Voros, H J Lamb, B Merkely, G Jermendy, P Maurovich-Horvat
BACKGROUND/OBJECTIVE: Various adipose tissue compartments play an important role in the development of cardiometabolic diseases. The quantity of different fat compartments is influenced by genetic and environmental factors. The aim of our study was to evaluate the magnitude of genetic and environmental effects on epicardial, subcutaneous and visceral adipose tissue (EAT, SAT and VAT) quantities in a cohort of adult twin pairs. SUBJECTS/METHODS: In this cross-sectional study we investigated adult twins (57 monozygotic [MZ] and 33 dizygotic [DZ] same-gender twin pairs; 180 twin subjects)...
August 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28843368/echocardiographic-epicardial-adipose-tissue-thickness-is-associated-with-symptomatic-coronary-vasospasm-during-provocative-testing
#11
Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Yukina Hirata, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Masataka Sata
BACKGROUND: Epicardial adipose tissue (EAT) is the ectopic visceral fat surrounding the heart, which plays an important role in atherosclerosis of the coronary arteries via endothelial damage. Several studies have also suggested that vasospasm with angina (VSA) causes endothelial dysfunction in the coronary arteries. The aim of this study was to evaluate the thickness of EAT in the anterior interventricular groove (EAT-AIG) using echocardiography in patients who had no obstructive coronary artery disease and were suspected of having VSA...
August 23, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28838916/association-of-epicardial-adipose-tissue-and-high-risk-plaque-characteristics-a-systematic-review-and-meta-analysis
#12
REVIEW
Nitesh Nerlekar, Adam J Brown, Rahul G Muthalaly, Andrew Talman, Thushan Hettige, James D Cameron, Dennis T L Wong
BACKGROUND: Epicardial adipose tissue (EAT) is hypothesized to alter atherosclerotic plaque composition, with potential development of high-risk plaque (HRP). EAT can be measured by volumetric assessment (EAT-v) or linear thickness (EAT-t). We performed a systematic review and random-effects meta-analysis to assess the association of EAT with HRP and whether this association is dependent on the measurement method used. METHODS AND RESULTS: Electronic databases were systematically searched up to October 2016...
August 23, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28837682/cardiac-computed-tomography-derived-epicardial-fat-volume-and-attenuation-independently-distinguish-patients-with-and-without-myocardial-infarction
#13
Amir Abbas Mahabadi, Bastian Balcer, Iryna Dykun, Michael Forsting, Thomas Schlosser, Gerd Heusch, Tienush Rassaf
BACKGROUND AND OBJECTIVE: Epicardial adipose tissue (EAT) volume is associated with coronary plaque burden and adverse events. We aimed to determine, whether CT-derived EAT attenuation in addition to EAT volume distinguishes patients with and without myocardial infarction. METHODS AND RESULTS: In 94 patients with confirmed or suspected coronary artery disease (aged 66.9±14.7years, 61%male) undergoing cardiac CT imaging as part of clinical workup, EAT volume was retrospectively quantified from non-contrast cardiac CT by delineation of the pericardium in axial images...
2017: PloS One
https://www.readbyqxmd.com/read/28821297/differential-expression-of-osteopontin-and-osteoprotegerin-mrna-in-epicardial-adipose-tissue-between-patients-with-severe-coronary-artery-disease-and-aortic-valvular-stenosis-association-with-hdl-subclasses
#14
María Luna-Luna, David Cruz-Robles, Nydia Ávila-Vanzzini, Valentín Herrera-Alarcón, Jesús Martínez-Reding, Sergio Criales-Vera, Julio Sandoval-Zárate, Jesús Vargas-Barrón, Carlos Martínez-Sánchez, Armando Roberto Tovar-Palacio, José Manuel Fragoso, Elizabeth Carreón-Torres, Gilberto Vargas-Alarcón, Óscar Pérez-Méndez
BACKGROUND: Previous studies suggest a relationship of the epicardial adipose tissue (EAT) with progression and calcification of the atherosclerotic plaque; however, it is unknown if this tissue expresses genes that may participate on these processes and if the expression of these genes is regulated by high-density lipoprotein (HDL) subclasses. METHODS: To explore this possibility, we determined the mRNA expression by qPCR of a pro-calcifying gene (osteopontin (OPN)), and two anti-calcifying genes (osteoprotegerin (OPG) and osteonectin (ON)), in biopsies of EAT obtained from 15 patients with coronary artery disease (CAD) determined by angiography, and 15 patients with diagnostic of aortic valve stenosis but without CAD as control group...
August 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28817459/relation-between-epicardial-fat-and-subclinical-atherosclerosis-in-asymptomatic-individuals
#15
Rami M Abazid, Osama A Smettei, Mohammad Obadah Kattea, Sawsan Sayed, Hanaa Saqqah, Adel M Widyan, Maksymilian P Opolski
PURPOSE: Excessive quantity of epicardial adipose tissue (EAT) is considered a risk factor for coronary artery disease (CAD). There are limited data, however, on the relationship between the quality of EAT and CAD. We investigated the association between the density and volume of EAT and subclinical CAD defined by positive coronary artery calcification (CAC), using computed tomography (CT). MATERIALS AND METHODS: We reviewed 609 consecutive CT scans of patients with a mild to moderate risk for CAD to assess the EAT volume, which was measured manually by tracing the parietal pericardial sac on axial images...
August 16, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28810263/association-between-c1q-tnf-related-protein-1-levels-in-human-plasma-and-epicardial-adipose-tissues-and-congestive-heart-failure
#16
Ying Yang, Si Liu, Rong-Yi Zhang, Hui Luo, Ling Chen, Wen-Feng He, Rong Lei, Mu-Rong Liu, Hou-Xiang Hu, Mao Chen
BACKGROUND/AIMS: C1q and tumour necrosis factor-related protein 1 (CTRP1) possesses anti-atherogenic and anti-inflammatory effects. This study investigated whether the CTRP1 levels in the plasma and epicardial adipose tissue (EAT) were associated with congestive heart failure (CHF) and to disclose possible molecular mechanisms. METHODS: Plasma and tissue samples were obtained from subjects with or without CHF. Plasma levels of CTRP1 were measured by ELISA. The mRNA levels of CTRP1 and inflammatory cytokines were detected by RT-PCR...
August 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28796027/heart-fat-in-hiv-marker-or-mediator-of-risk
#17
Jonathan Buggey, Chris T Longenecker
PURPOSE OF REVIEW: The review aims to summarize the literature describing the clinical impact of cardiac fat depots in patients with HIV infection. RECENT FINDINGS: People living with HIV (PLHIV) have accelerated rates of cardiovascular disease, and are prone to the development of ectopic fat deposition. Specifically, PLHIV have higher volumes of epicardial and intracardiac fat quantified by noninvasive imaging. Higher volumes of epicardial fat may be related to antiretroviral therapy duration and chronic inflammation, independently of other measures of body adiposity such as BMI...
August 8, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28766048/association-of-epicardial-adipose-tissue-with-coronary-spasm-and-coronary-atherosclerosis-in-patients-with-chest-pain-analysis-of-data-collated-by-the-korean-women-s-chest-pain-registry-korose
#18
Mi-Na Kim, Hack-Lyoung Kim, Seong-Mi Park, Mi Seung Shin, Cheol Woong Yu, Myung-A Kim, Kyung-Soon Hong, Wan-Joo Shim
Epicardial adipose tissue (EAT) represents a cardio-metabolic risk factor; it secretes several adipokines related to coronary atherosclerosis. However, the precise relationship between EAT and coronary vasospasm is unknown. This study aimed to investigate the relationship between EAT and coronary vasospasm using data from the KoRean wOmen'S chest pain rEgistry (koROSE). This study included 551 patients (female/male = 366/185; mean age = 60.2 ± 10.2 years) who presented with chest pain at an outpatient clinic, and who subsequently underwent echocardiography and coronary angiography...
August 1, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28765757/vagal-response-in-cryoballoon-ablation-of-atrial-fibrillation-and-autonomic-nervous-system-utility-of-epicardial-adipose-tissue-location
#19
Satoshi Yanagisawa, Yasuya Inden, Yoshiaki Mizutani, Aya Fujii, Yosuke Kamikubo, Yasunori Kanzaki, Monami Ando, Junya Funabiki, Yosuke Murase, Masaki Takenaka, Noriaki Otake, Tetsuyoshi Hattori, Rei Shibata, Toyoaki Murohara
BACKGROUND: Mechanism and effects of vagal response (VR) during cryoballoon ablation procedure on the cardiac autonomic nervous system (ANS) are unclear. The present study aimed to evaluate the relationship between VR during cryoballoon catheter ablation for atrial fibrillation and ANS modulation by evaluating epicardial adipose tissue (EAT) locations and heart rate variability (HRV) analysis. METHODS: Forty-one patients with paroxysmal atrial fibrillation (11 with VR during the procedure and 30 without VR) who underwent second-generation cryoballoon ablation were included...
August 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28762019/epicardial-adipose-tissue-as-a-metabolic-transducer-role-in-heart-failure-and-coronary-artery-disease
#20
REVIEW
Vaibhav B Patel, Saumya Shah, Subodh Verma, Gavin Y Oudit
Obesity and diabetes are strongly associated with metabolic and cardiovascular disorders including dyslipidemia, coronary artery disease, hypertension, and heart failure. Adipose tissue is identified as a complex endocrine organ, which by exerting a wide array of regulatory functions at the cellular, tissue and systemic levels can have profound effects on the cardiovascular system. Different terms including "epicardial," "pericardial," and "paracardial" have been used to describe adipose tissue deposits surrounding the heart...
July 31, 2017: Heart Failure Reviews
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