keyword
MENU ▼
Read by QxMD icon Read
search

RIVUR

keyword
https://www.readbyqxmd.com/read/27713802/the-role-of-voiding-cystourethrography-in-the-investigation-of-children-with-urinary-tract-infections
#1
Linda C Lee, Armando J Lorenzo, Martin A Koyle
Urinary tract infections (UTIs) represent a common bacterial cause of febrile illness in children. Of children presenting with a febrile UTI, 25-40% are found to have vesicoureteral reflux (VUR). Historically, the concern regarding VUR was that it could lead to recurrent pyelonephritis, renal scarring, hypertension, and chronic kidney disease. As a result, many children underwent invasive surgical procedures to correct VUR. We now know that many cases of VUR are low-grade and have a high rate of spontaneous resolution...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27666144/reliability-of-grading-of-vesicoureteral-reflux-and-other-findings-on-voiding-cystourethrography
#2
Anthony J Schaeffer, Saul P Greenfield, Anastasia Ivanova, Gang Cui, J Michael Zerin, Jeanne S Chow, Alejandro Hoberman, Ranjiv I Mathews, Tej K Mattoo, Myra A Carpenter, Marva Moxey-Mims, Russell W Chesney, Caleb P Nelson
INTRODUCTION: Voiding cystourethrography (VCUG) is the modality of choice to diagnose vesicoureteral reflux (VUR). Although grading of VUR is essential for prognosis and clinical decision-making, the inter-observer reliability for grading has been shown to vary substantially. The Randomized Intervention for Children with VesicoUreteral Reflux (RIVUR) trial provides a large cohort of children with VUR to better understand the reliability of VCUG findings. OBJECTIVE: To determine the inter-observer consistency of the grade of VUR and other VCUG findings in a large cohort of children with VUR...
September 6, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/26969273/antimicrobial-resistance-and-urinary-tract-infection-recurrence
#3
Caleb P Nelson, Alejandro Hoberman, Nader Shaikh, Ron Keren, Ranjiv Mathews, Saul P Greenfield, Tej K Mattoo, Nathan Gotman, Anastasia Ivanova, Marva Moxey-Mims, Myra A Carpenter, Russell W Chesney
BACKGROUND: The Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial found that recurrent urinary tract infections (rUTI) with resistant organisms were more common in the trimethoprim-sulfamethoxazole prophylaxis (TSP) arm. We describe factors associated with trimethoprim-sulfamethoxazole (TMP-SMX) resistance of rUTIs in RIVUR. METHODS: Children aged 2 to 71 months with first or second UTI (index UTI) and grade I to IV vesicoureteral reflux (VUR) were randomized to TSP or placebo and followed for 2 years...
April 2016: Pediatrics
https://www.readbyqxmd.com/read/26940096/polymorphisms-in-%C3%AE-defensin-encoding-defa1a3-associate-with-urinary-tract-infection-risk-in-children-with-vesicoureteral-reflux
#4
Andrew L Schwaderer, Huanyu Wang, SungHwan Kim, Jennifer M Kline, Dong Liang, Pat D Brophy, Kirk M McHugh, George C Tseng, Vijay Saxena, Evan Barr-Beare, Keith R Pierce, Nader Shaikh, J Robert Manak, Daniel M Cohen, Brian Becknell, John D Spencer, Peter B Baker, Chack-Yung Yu, David S Hains
The contribution of genetic variation to urinary tract infection (UTI) risk in children with vesicoureteral reflux is largely unknown. The innate immune system, which includes antimicrobial peptides, such as the α-defensins, encoded by DEFA1A3, is important in preventing UTIs but has not been investigated in the vesicoureteral reflux population. We used quantitative real-time PCR to determine DEFA1A3 DNA copy numbers in 298 individuals with confirmed UTIs and vesicoureteral reflux from the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) Study and 295 controls, and we correlated copy numbers with outcomes...
October 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/26555605/renal-scarring-in-the-randomized-intervention-for-children-with-vesicoureteral-reflux-rivur-trial
#5
RANDOMIZED CONTROLLED TRIAL
Tej K Mattoo, Russell W Chesney, Saul P Greenfield, Alejandro Hoberman, Ron Keren, Ranjiv Mathews, Lisa Gravens-Mueller, Anastasia Ivanova, Myra A Carpenter, Marva Moxey-Mims, Massoud Majd, Harvey A Ziessman
BACKGROUND AND OBJECTIVES: The main objectives of the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial were to evaluate the role of antimicrobial prophylaxis in the prevention of recurrent urinary tract infection (UTI) and renal scarring in children with vesicoureteral reflux (VUR). We present a comprehensive evaluation of renal scarring outcomes in RIVUR trial participants. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This multicenter, randomized, placebo-controlled trial enrolled 607 children aged 2-71 months with grade 1-4 VUR diagnosed after a first or second febrile or symptomatic UTI...
January 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26088078/the-role-of-antimicrobial-prophylaxis-in-the-management-of-children-with-vesicoureteral-reflux-the-rivur-study-outcomes
#6
REVIEW
Ranjiv Mathews, Tej K Mattoo
The role of antimicrobial prophylaxis for the prevention of recurrent urinary tract infections in children with vesicoureteral reflux that was identified following a urinary tract infection has been the source of considerable debate. Prior studies had failed to show a benefit in the prevention of recurrent infection. The National Institutes of Health funded the Randomized Intervention for Vesicoureteral Reflux (RIVUR) study to determine if there was a benefit to the use of prophylaxis. Results of the RIVUR study indicated that there was a 50% reduction in the risk of recurrent urinary tract infection in those children on the prophylaxis arm...
July 2015: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/26055855/risk-factors-for-recurrent-urinary-tract-infection-and-renal-scarring
#7
RANDOMIZED CONTROLLED TRIAL
Ron Keren, Nader Shaikh, Hans Pohl, Lisa Gravens-Mueller, Anastasia Ivanova, Lisa Zaoutis, Melissa Patel, Rachel deBerardinis, Allison Parker, Sonika Bhatnagar, Mary Ann Haralam, Marcia Pope, Diana Kearney, Bruce Sprague, Raquel Barrera, Bernarda Viteri, Martina Egigueron, Neha Shah, Alejandro Hoberman
OBJECTIVES: To identify risk factors for recurrent urinary tract infection (UTI) and renal scarring in children who have had 1 or 2 febrile or symptomatic UTIs and received no antimicrobial prophylaxis. METHODS: This 2-year, multisite prospective cohort study included 305 children aged 2 to 71 months with vesicoureteral reflux (VUR) receiving placebo in the RIVUR (Randomized Intervention for Vesicoureteral Reflux) study and 195 children with no VUR observed in the CUTIE (Careful Urinary Tract Infection Evaluation) study...
July 2015: Pediatrics
https://www.readbyqxmd.com/read/26016296/antibiotic-prophylaxis-in-children-with-vesicoureteric-reflux-has-rivur-answered-all-our-questions
#8
EDITORIAL
C W Teoh, A Awan
No abstract text is available yet for this article.
April 2015: Irish Medical Journal
https://www.readbyqxmd.com/read/25817142/antibiotic-prophylaxis-for-prevention-of-febrile-urinary-tract-infections-in-children-with-vesicoureteral-reflux-a-meta-analysis-of-randomized-controlled-trials-comparing-dilated-to-nondilated-vesicoureteral-reflux
#9
Jose de Bessa, Flavia Cristina de Carvalho Mrad, Evilin Feitosa Mendes, Marcia Carvalho Bessa, Victor Pereira Paschoalin, Ricardo Brianezi Tiraboschi, Zein Mohamed Sammour, Cristiano Mendes Gomes, Luis H Braga, José Murillo Bastos Netto
PURPOSE: The followup and treatment of children with vesicoureteral reflux has been debated for many years. Antibiotic prophylaxis has a role for preventing urinary tract infection in these children. Recent studies and guidelines suggested that prophylaxis has little or no role in preventing urinary tract infection in those children, especially those with low grades (I and II) of reflux. MATERIALS AND METHODS: We analyzed all published randomized, controlled trials comparing antibiotic prophylaxis vs no prophylaxis or placebo in children with vesicoureteral reflux...
May 2015: Journal of Urology
https://www.readbyqxmd.com/read/25558811/the-rivur-trial-a-factual-interpretation-of-our-data
#10
EDITORIAL
Tej K Mattoo, Myra A Carpenter, Marva Moxey-Mims, Russell W Chesney
Vesicoureteral reflux (VUR) increases the risk of urinary tract infection (UTI) and renal scarring. Many prospective studies have evaluated the role of antimicrobial prophylaxis in the prevention of recurrent UTI and renal scarring in children with VUR. Of these, the RIVUR trial was the largest, randomized, placebo-controlled, double blind, multicenter study, involving 607 children aged 2-72 months with grade I-IV VUR and a first or second symptomatic UTI. The median age of children in the RIVUR trial was 12 months, 92% were female, 91% were randomized after a first UTI, 86% had a febrile index UTI, and 71 (56%) of 126 toilet-trained children had bladder bowel dysfunction...
May 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/25503325/the-rivur-study-a-review-of-its-findings
#11
EDITORIAL
Gabriel Cara-Fuentes, Nirupama Gupta, Eduardo H Garin
BACKGROUND: The conclusion drawn by the authors of the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial is that antimicrobial prophylaxis reduces the risk of recurrent urinary tract infection (UTI)-but not of renal scarring-in patients with vesicoureteral reflux (VUR). RESULTS: A review of the findings showed that the decreased recurrent UTI rate was only present at the end of the 2-year follow-up period and was only slightly increased (12...
May 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/25189165/rivur-trial-offers-confirmatory-evidence-for-a-small-but-real-benefit-of-antibiotics-for-uti-prevention-in-children
#12
COMMENT
Gabrielle Williams, Jonathan Craig
No abstract text is available yet for this article.
December 2014: Evidence-based Medicine
https://www.readbyqxmd.com/read/24841170/paediatrics-antimicrobial-prophylaxis-for-vesicoureteral-reflux-where-will-the-rivur-study-lead-us
#13
COMMENT
Melanie Clyne
No abstract text is available yet for this article.
June 2014: Nature Reviews. Urology
https://www.readbyqxmd.com/read/24795142/antimicrobial-prophylaxis-for-children-with-vesicoureteral-reflux
#14
RANDOMIZED CONTROLLED TRIAL
Alejandro Hoberman, Saul P Greenfield, Tej K Mattoo, Ron Keren, Ranjiv Mathews, Hans G Pohl, Bradley P Kropp, Steven J Skoog, Caleb P Nelson, Marva Moxey-Mims, Russell W Chesney, Myra A Carpenter
BACKGROUND: Children with febrile urinary tract infection commonly have vesicoureteral reflux. Because trial results have been limited and inconsistent, the use of antimicrobial prophylaxis to prevent recurrences in children with reflux remains controversial. METHODS: In this 2-year, multisite, randomized, placebo-controlled trial involving 607 children with vesicoureteral reflux that was diagnosed after a first or second febrile or symptomatic urinary tract infection, we evaluated the efficacy of trimethoprim-sulfamethoxazole prophylaxis in preventing recurrences (primary outcome)...
June 19, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/23753091/the-rivur-trial-profile-and-baseline-clinical-associations-of-children-with-vesicoureteral-reflux
#15
RANDOMIZED CONTROLLED TRIAL
Myra A Carpenter, Alejandro Hoberman, Tej K Mattoo, Ranjiv Mathews, Ron Keren, Russell W Chesney, Marva Moxey-Mims, Saul P Greenfield
BACKGROUND AND OBJECTIVE: Vesicoureteral reflux (VUR) is diagnosed in ∼30% to 40% of children who have imaging studies after urinary tract infections (UTIs). Our goal is to characterize children enrolled in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial and to compare our study cohort with those from previously published studies. METHODS: RIVUR investigators from 19 pediatric sites in the United States recruited 607 children with grade I through IV VUR...
July 2013: Pediatrics
https://www.readbyqxmd.com/read/22910235/the-rivur-voiding-cystourethrogram-pilot-study-experience-with-radiologic-reading-concordance
#16
MULTICENTER STUDY
Saul P Greenfield, Myra A Carpenter, Russell W Chesney, J Michael Zerin, Jean Chow
PURPOSE: Two reference radiologists independently review voiding cystourethrograms for the National Institutes of Health sponsored RIVUR (Randomized Intervention for Children with Vesicoureteral Reflux) trial for children with vesicoureteral reflux. A pilot study was required from all clinical centers before enrolling patients. MATERIALS AND METHODS: Digital images were reviewed. Responses were compared and discrepancies adjudicated by teleconference to a final assessment...
October 2012: Journal of Urology
https://www.readbyqxmd.com/read/22619135/vesicoureteric-reflux-vur-in-children-where-are-we-now
#17
REVIEW
K Slabbaert, G Bogaert
In 1960 Hodson and Edwards published their landmark paper about the association between chronic pyelonefritis and vesicoureteric reflux (VUR). Since then, the approach for VUR became more important (1). In the last 30 years there have been multiple publications on vesicoureteric reflux (VUR) and discussions at Pediatric Urology meetings with the purpose to give answers to the questions what the best treatment is for VUR, at what age the treatment is advocated, does it prevent for febrile urinary tract infections (UTI's) and does it stop of decreases the risk for reflux nefropathy and renal scars Well known are the International Reflux Study (1981) with a European and an American arm in which the researchers compared medical approaches with surgical approaches to reflux, and the Birmingham Reflux study (1987) which was a prospective trial of operative versus non-operative treatment of severe vesicoureteric reflux in children with five years observation (2)...
May 2012: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/21873693/urinary-tract-infection-clinical-practice-guideline-for-the-diagnosis-and-management-of-the-initial-uti-in-febrile-infants-and-children-2-to-24-months
#18
Kenneth B Roberts
OBJECTIVE: To revise the American Academy of Pediatrics practice parameter regarding the diagnosis and management of initial urinary tract infections (UTIs) in febrile infants and young children. METHODS: Analysis of the medical literature published since the last version of the guideline was supplemented by analysis of data provided by authors of recent publications. The strength of evidence supporting each recommendation and the strength of the recommendation were assessed and graded...
September 2011: Pediatrics
https://www.readbyqxmd.com/read/19674938/commentary-to-controversies-in-the-management-of-vesicoureteral-reflux-the-rationale-for-the-rivur-study-urinary-tract-infections-and-vesicoureteral-reflux-in-childen-what-have-we-learned
#19
COMMENT
https://www.readbyqxmd.com/read/19663037/are-prophylactic-antibiotics-indicated-after-a-urinary-tract-infection
#20
REVIEW
Tej K Mattoo
PURPOSE OF REVIEW: Many children with urinary tract infection (UTI) and urinary tract abnormality such as vesicoureteral reflux (VUR) are given prophylactic antibiotic to prevent recurrence of UTI and permanent kidney damage. Occasionally, children with normal urinary tract receive prophylactic antibiotic to alleviate the patient suffering and family inconvenience associated with recurrent symptomatic UTI. These recommendations are mostly opinion-based and are derived from studies that were not randomized and were done before the current renal imaging modalities became available...
April 2009: Current Opinion in Pediatrics
keyword
keyword
24654
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"