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https://www.readbyqxmd.com/read/28208636/structural-health-monitoring-using-textile-reinforcement-structures-with-integrated-optical-fiber-sensors
#1
Kort Bremer, Frank Weigand, Yulong Zheng, Lourdes Shanika Alwis, Reinhard Helbig, Bernhard Roth
Optical fiber-based sensors "embedded" in functionalized carbon structures (FCSs) and textile net structures (TNSs) based on alkaline-resistant glass are introduced for the purpose of structural health monitoring (SHM) of concrete-based structures. The design aims to monitor common SHM parameters such as strain and cracks while at the same time acting as a structural strengthening mechanism. The sensor performances of the two systems are characterized in situ using Mach-Zehnder interferometric (MZI) and optical attenuation measurement techniques, respectively...
February 10, 2017: Sensors
https://www.readbyqxmd.com/read/28146067/a-review-of-passive-rfid-tag-antenna-based-sensors-and-systems-for-structural-health-monitoring-applications
#2
REVIEW
Jun Zhang, Gui Yun Tian, Adi M J Marindra, Ali Imam Sunny, Ao Bo Zhao
In recent few years, the antenna and sensor communities have witnessed a considerable integration of radio frequency identification (RFID) tag antennas and sensors because of the impetus provided by internet of things (IoT) and cyber-physical systems (CPS). Such types of sensor can find potential applications in structural health monitoring (SHM) because of their passive, wireless, simple, compact size, and multimodal nature, particular in large scale infrastructures during their lifecycle. The big data from these ubiquitous sensors are expected to generate a big impact for intelligent monitoring...
January 29, 2017: Sensors
https://www.readbyqxmd.com/read/28113846/an-integrated-acousto-ultrasonic-structural-health-monitoring-system-for-composite-pressure-vessels
#3
Andrea Bulletti, Pietro Giannelli, Marco Calzolai, Lorenzo Capineri
This paper describes the implementation of a Structural Health Monitoring (SHM) method for mechanical components and structures in composite materials with a focus on Carbon Fiber Overwrapped Pressure Vessels (COPV) used in the aerospace industry. Two flex arrays of PVDF interdigital transducers have been designed, realized and mounted on the COPV to generate guided Lamb waves (mode A0) for damage assessment. We developed a custom electronic instrument capable of performing two functions using the same transducers: passive mode detection of impacts and active mode damage assessment using Lamb waves...
March 23, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28104464/genetic-defects-in-pi3k%C3%AE-affect-b-cell-differentiation-and-maturation-leading-to-hypogammaglobulineamia-and-recurrent-infections
#4
Marjolein Wentink, Virgil Dalm, Arjan C Lankester, Pauline A van Schouwenburg, Liesbeth Schölvinck, Tomas Kalina, Radana Zachova, Anna Sediva, Annechien Lambeck, Ingrid Pico-Knijnenburg, Jacques J M van Dongen, Malgorzata Pac, Ewa Bernatowska, Martin van Hagen, Gertjan Driessen, Mirjam van der Burg
BACKGROUND: Mutations in PIK3CD and PIK3R1 cause activated PI3K-δ syndrome (APDS) by dysregulation of the PI3K-AKT pathway. METHODS: We studied precursor and peripheral B-cell differentiation and apoptosis via flowcytometry. Furthermore, we performed AKT-phosphorylation assays and somatic hypermutations (SHM) and class switch recombination (CSR) analysis. RESULTS: We identified 13 patients of whom 3 had new mutations in PIK3CD or PIK3R1. Patients had low total B-cell numbers with increased frequencies of transitional B cells and plasmablasts, while the precursor B-cell compartment in bone marrow was relatively normal...
January 17, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28088785/the-igh-locus-3-cis-regulatory-super-enhancer-co-opts-aid-for-allelic-transvection
#5
Sandrine Le Noir, Brice Laffleur, Claire Carrion, Armand Garot, Sandrine Lecardeur, Eric Pinaud, Yves Denizot, Jane Skok, Michel Cogné
Immunoglobulin heavy chain (IgH) alleles have ambivalent relationships: they feature both allelic exclusion, ensuring monoallelic expression of a single immunoglobulin (Ig) allele, and frequent inter-allelic class-switch recombination (CSR) reassembling genes from both alleles. The IgH locus 3' regulatory region (3'RR) includes several transcriptional cis-enhancers promoting activation-induced cytidine deaminase (AID)-dependent somatic hypermutation (SHM) and CSR, and altogether behaves as a strong super-enhancer...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28080021/an-ionic-liquid-as-interface-linker-for-tuning-piezoresistive-sensitivity-and-toughness-in-poly-vinylidene-fluoride-carbon-nanotube-composites
#6
Kai Ke, Petra Pötschke, Shanglin Gao, Brigitte Voit
Conductive polymer nanocomposites (CPNCs) have emerged as potential alternatives for metallic foil sensors and semiconductor strain gauges. The simultaneous achievement of high piezoresistive sensitivity and large strain ranges for CPNCs currently presents a great challenge and solving this challenge may extend the applications of CPNCs with self-diagnosis capabilities to many structural health-monitoring (SHM) systems. This paper reports a facile strategy for fabricating highly piezoresistive and tough poly(vinylidene fluoride) (PVDF) based CPNCs by tuning the interactions between the polymer matrix and multiwalled carbon nanotubes (CNT) using an ionic liquid (IL) as an interface linker/modifier...
February 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28069372/rna-exosome-and-non-coding-rna-coupled-mechanisms-in-aid-mediated-genomic-alterations
#7
REVIEW
Brice Laffleur, Uttiya Basu, Junghyun Lim
The eukaryotic RNA exosome is a well-conserved protein complex with ribonuclease activity implicated in RNA metabolism. Various families of non-coding RNAs have been identified as substrates of the complex, underscoring its role as a non-coding RNA processing/degradation unit. However, the role of RNA exosome and its RNA processing activity on DNA mutagenesis/alteration events have not been investigated until recently. B lymphocytes use two DNA alteration mechanisms, class switch recombination (CSR) and somatic hypermutation (SHM), to re-engineer their antibody gene expressing loci until a tailored antibody gene for a specific antigen is satisfactorily generated...
January 7, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28058944/epilepsy-in-hemiplegic-migraine-genetic-mutations-and-clinical-implications
#8
P Prontera, P Sarchielli, S Caproni, C Bedetti, L M Cupini, P Calabresi, C Costa
Objective We performed a systematic review on the comorbidities of familial/sporadic hemiplegic migraine (F/SHM) with seizure/epilepsy in patients with CACNA1A, ATP1A2 or SCN1A mutations, to identify the genotypes associated and investigate for the presence of mutational hot spots. Methods We performed a search in MEDLINE and in the Human Gene Mutation and Leiden Open Variation Databases for mutations in the CACNA1A, ATP1A2 and SCN1A genes. After having examined the clinical characteristics of the patients, we selected those having HM and seizures, febrile seizures or epilepsy...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28012949/cannabidiol-reduces-brain-damage-and-improves-functional-recovery-in-a-neonatal-rat-model-of-arterial-ischemic-stroke
#9
Maria Ceprián, Laura Jiménez-Sánchez, Carlos Vargas, Lorena Barata, Will Hind, Jose Martínez-Orgado
BACKGROUND: and purpose: Currently there is no effective treatment for neonatal arterial ischemic stroke (AIS). Cannabidiol (CBD) is neuroprotective in models of newborn hypoxic-ischemic brain damage and adult stroke. The purpose of this work was to study the protective effect of CBD in a neonatal rat model of AIS. METHODS: Middle Cerebral Artery Occlusion (MCAO) was achieved in neonatal Wistar rats by introducing a nylon filament to the left MCA for 3 h; 15 min after removing the occluder vehicle (MCAO-V) or CBD single dose 5 mg/kg (MCAO-C) were administered i...
December 21, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27999245/tapered-polymer-fiber-sensors-for-reinforced-concrete-beam-vibration-detection
#10
Dong Luo, Zainah Ibrahim, Jianxun Ma, Zubaidah Ismail, David Thomas Iseley
In this study, tapered polymer fiber sensors (TPFSs) have been employed to detect the vibration of a reinforced concrete beam (RC beam). The sensing principle was based on transmission modes theory. The natural frequency of an RC beam was theoretically analyzed. Experiments were carried out with sensors mounted on the surface or embedded in the RC beam. Vibration detection results agreed well with Kistler accelerometers. The experimental results found that both the accelerometer and TPFS detected the natural frequency function of a vibrated RC beam well...
December 16, 2016: Sensors
https://www.readbyqxmd.com/read/27998928/the-cell-cycle-restricts-activation-induced-cytidine-deaminase-activity-to-early-g1
#11
Qiao Wang, Kyong-Rim Kieffer-Kwon, Thiago Y Oliveira, Christian T Mayer, Kaihui Yao, Joy Pai, Zhen Cao, Marei Dose, Rafael Casellas, Mila Jankovic, Michel C Nussenzweig, Davide F Robbiani
Activation-induced cytidine deaminase (AID) converts cytosine into uracil to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of antibody genes. In addition, this enzyme produces DNA lesions at off-target sites that lead to mutations and chromosome translocations. However, AID is mostly cytoplasmic, and how and exactly when it accesses nuclear DNA remains enigmatic. Here, we show that AID is transiently in spatial contact with genomic DNA from the time the nuclear membrane breaks down in prometaphase until early G1, when it is actively exported into the cytoplasm...
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27973450/airborne-transducer-integrity-under-operational-environment-for-structural-health-monitoring
#12
Mohammad Saleh Salmanpour, Zahra Sharif Khodaei, Mohammad Hossein Aliabadi
This paper investigates the robustness of permanently mounted transducers used in airborne structural health monitoring systems, when exposed to the operational environment. Typical airliners operate in a range of conditions, hence, structural health monitoring (SHM) transducer robustness and integrity must be demonstrated for these environments. A set of extreme temperature, altitude and vibration environment test profiles are developed using the existing Radio Technical Commission for Aeronautics (RTCA)/DO-160 test methods...
December 12, 2016: Sensors
https://www.readbyqxmd.com/read/27957330/evidence-of-perturbed-germinal-center-dynamics-but-preserved-antibody-diversity-in-end-stage-renal-disease
#13
Kristian Assing, Christian Nielsen, Marianne Jakobsen, Alexandra Scholze, Mads Nybo, Grete Soerensen, Sussie Mortensen, Knud Vejen, Torben Barington, Claus Bistrup
INTRODUCTION: End-stage renal disease (ESRD) is associated with increased infectious susceptibility and with reduced vaccine responses consistent with compromised humoral immunity. Whether the compromised humoral immunity is due to reduced antibody diversity (reduced somatic hypermutation [SHM]) or altered germinal center (GC) dynamics is not known. The GC-derived chemokine CXCL13 as well as peripheral T follicular helper cells (pTFH) reflect GC dynamics, but have, similar to SHM, never been characterized in relation to ESRD...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27924834/activation-induced-deaminase-mutational-signature-overlaps-with-cpg-methylation-sites-in-follicular-lymphoma-and-other-cancers
#14
Igor B Rogozin, Artem G Lada, Alexander Goncearenco, Michael R Green, Subhajyoti De, German Nudelman, Anna R Panchenko, Eugene V Koonin, Youri I Pavlov
Follicular lymphoma (FL) is an uncurable cancer characterized by progressive severity of relapses. We analyzed sequence context specificity of mutations in the B cells from a large cohort of FL patients. We revealed substantial excess of mutations within a novel hybrid nucleotide motif: the signature of somatic hypermutation (SHM) enzyme, Activation Induced Deaminase (AID), which overlaps the CpG methylation site. This finding implies that in FL the SHM machinery acts at genomic sites containing methylated cytosine...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920779/functional-versatility-of-agy-serine-codons-in-immunoglobulin-variable-region-genes
#15
Thiago Detanico, Matthew Phillips, Lawrence J Wysocki
In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ags) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY Ser codons are far more abundant in complementarity-determining regions (CDRs) of IgV-region genes than expected for random codon use or from species-specific codon frequency data. CDR AGY codons are also more abundant than TCN Ser codons. We show that these trends hold even in cartilaginous fishes...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27909816/ecological-and-physical-barriers-shape-genetic-structure-of-the-alpine-porcini-boletus-reticuloceps
#16
Bang Feng, Jian Wei Liu, Jianping Xu, Kuan Zhao, Zai Wei Ge, Zhu L Yang
The Alpine porcini, Boletus reticuloceps, is an ectomycorrhizal mushroom distributed in subalpine areas of Southwest China, central China, and Taiwan Island. This distribution pattern makes it an ideal organism to infer how ectomycorrhizal fungi have reacted to historical tectonic and climatic changes, and to illustrate the mechanism for the disjunction of organisms between Southwest China and Taiwan. In this study, we explored the phylogeographic pattern of B. reticuloceps by microsatellite genotyping, DNA sequencing, ecological factor analysis, and species distribution modeling...
December 1, 2016: Mycorrhiza
https://www.readbyqxmd.com/read/27816871/a-new-omnidirectional-shear-horizontal-wave-transducer-using-face-shear-d24-piezoelectric-ring-array
#17
Hongchen Miao, Qiang Huan, Qiangzhong Wang, Faxin Li
The non-dispersive fundamental shear horizontal (SH0) wave in plate-like structures is of practical importance in non-destructive testing (NDT) and structural health monitoring (SHM). Theoretically, an omnidirectional SH0 transducer phased array system can be used to inspect defects in a large plate in the similar manner to the phased array transducers used in medical B-scan ultrasonics. However, very few omnidirectional SH0 transducers have been proposed so far. In this work, an omnidirectional SH0 wave piezoelectric transducer (OSH-PT) was proposed, which consists of a ring array of twelve face-shear (d24) trapezoidal PZT elements...
February 2017: Ultrasonics
https://www.readbyqxmd.com/read/27814386/convex-grooves-in-staggered-herringbone-mixer-improve-mixing-efficiency-of-laminar-flow-in-microchannel
#18
Tae Joon Kwak, Young Gyu Nam, Maria Alejandra Najera, Sang Woo Lee, J Rudi Strickler, Woo-Jin Chang
The liquid streams in a microchannel are hardly mixed to form laminar flow, and the mixing issue is well described by a low Reynolds number scheme. The staggered herringbone mixer (SHM) using repeated patterns of grooves in the microchannel have been proved to be an efficient passive micro-mixer. However, only a negative pattern of the staggered herringbone mixer has been used so far after it was first suggested, to the best of our knowledge. In this study, the mixing efficiencies from negative and positive staggered herringbone mixer patterns as well as from opposite flow directions were tested to investigate the effect of the micro-structure geometry on the surrounding laminar flow...
2016: PloS One
https://www.readbyqxmd.com/read/27799928/evaluation-of-the-antigen-experienced-b-cell-receptor-repertoire-in-healthy-children-and-adults
#19
Hanna IJspeert, Pauline A van Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J Driessen, Andrew P Stubbs, Mirjam van der Burg
Upon antigen recognition via their B cell receptor (BR), B cells migrate to the germinal center where they undergo somatic hypermutation (SHM) to increase their affinity for the antigen, and class switch recombination (CSR) to change the effector function of the secreted antibodies. These steps are essential to create an antigen-experienced BR repertoire that efficiently protects the body against pathogens. At the same time, the BR repertoire should be selected to protect against responses to self-antigen or harmless antigens...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27744360/chronic-signs-of-memory-b-cell-activation-in-patients-with-beh%C3%A3-et-s-disease-are-partially-restored-by-anti-tumour-necrosis-factor-treatment
#20
Tim B van der Houwen, P Martin van Hagen, Wilhemina M C Timmermans, Sophinus J W Bartol, King H Lam, Jasper H Kappen, Menno C van Zelm, Jan A M van Laar
OBJECTIVES: Behçet's disease (BD), an auto-inflammatory vasculitis with oro-genital ulcerations, skin lesions and uveitis, is regarded as T cell mediated. A successful trial with rituximab suggests an additive role for B cells in the pathogenesis. Therefore, we studied B cell abnormalities in BD patients and the effect of TNF-blocking therapy. METHODS: B cells in blood (n = 36) and tissue (n = 6) of BD patients were analysed with flow cytometry and/or immunohistochemistry and compared with healthy controls (n = 22)...
January 2017: Rheumatology
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