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https://www.readbyqxmd.com/read/29141383/-critical-elements-of-cataract-prevention-work-in-china
#1
P Liu, H D Zou, A L Hu, M G He
Surgical treatment of cataract is the emphasis of prevention of blindness in China. In the past ten years, cataract prevention work has made great strides. However, the cataract surgery rate (CSR) in one million people is still far away from the developed countries, and not enough to eliminate the blindness of cataract in our country. The CSR is related to many factors. In this article, the issue of the CSR increase is commented from four aspects, including improving the quantity and quality of cataract surgery, increasing the allocation of ophthalmic resources to primary hospitals, strengthening the cooperation between the urban and backward areas in ophthalmology, and the economic factors...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29136157/depletion-of-recombination-specific-co-factors-by-the-c-terminal-mutant-of-the-activation-induced-cytidine-deaminase-causes-the-dominant-negative-effect-on-class-switch-recombination
#2
Azza Al Ismail, Afzal Husain, Maki Kobayashi, Tasuku Honjo, Nasim A Begum
Activation-induced cytidine deaminase (AID) is essential for class-switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin (Ig) genes. Studies on in vitro mutagenized AID as well as its mutations in human patients with Hyper-IgM (HIGM)-syndrome type II revealed that C-terminal AID mutations were defective in CSR whereas their DNA cleavage and SHM activities remained intact. The C-terminal mutants of AID were speculated to exert the dominant negative effect on wild type WT AID whereas its mechanism remains unknown...
November 10, 2017: International Immunology
https://www.readbyqxmd.com/read/29122947/phosphorylation-promotes-activation-induced-cytidine-deaminase-activity-at-the-myc-oncogene
#3
Yunxiang Mu, Monika A Zelazowska, Kevin M McBride
Activation-induced cytidine deaminase (AID) is a mutator enzyme that targets immunoglobulin (Ig) genes to initiate antibody somatic hypermutation (SHM) and class switch recombination (CSR). Off-target AID association also occurs, which causes oncogenic mutations and chromosome rearrangements. However, AID occupancy does not directly correlate with DNA damage, suggesting that factors beyond AID association contribute to mutation targeting. CSR and SHM are regulated by phosphorylation on AID serine38 (pS38), but the role of pS38 in off-target activity has not been evaluated...
November 9, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29109689/molecular-plasticity-under-ocean-warming-proteomics-and-fitness-data-provides-clues-for-a-better-understanding-of-the-thermal-tolerance-in-fish
#4
Diana Madeira, José E Araújo, Rui Vitorino, Pedro M Costa, José L Capelo, Catarina Vinagre, Mário S Diniz
Ocean warming is known to alter the performance and fitness of marine organisms albeit the proteome underpinnings of species thermal tolerance are still largely unknown. In this 1-month experiment we assessed the vulnerability of the gilt-head sea bream Sparus aurata, taken here as a biological model for some key fisheries species, to ocean warming (control 18°C, nursery ground temperature 24°C and heat wave 30°C). Survival was impaired after 28 days, mainly at 30°C although fishes' condition was unaltered...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29102807/microstructural-cerebral-lesions-are-associated-with-the-severity-of-central-sleep-apnea-with-cheyne-stokes-respiration-in-heart-failure-and-are-modified-by-pap-therapy
#5
Anna Heidbreder, Jens Spießhöfer, Jörg Stypmann, Matthias Boentert, Peter Young, Thomas Duning
This study investigated the association of microstructural cerebral lesions with central sleep apnea with Cheyne-Stokes-respiration (CSA-CSR) in heart failure (HF) patients and the effect of positive airway pressure therapy (PAP) of CSA-CSR on these lesions. PAP-therapy was initiated in patients with HF with midrange and with reduced ejection fraction (NYHA≥II; left ventricular ejection fraction <50%) and proven CSA-CSR. Cerebral magnetic resonance imaging (MRI) scans at 3T including diffusion tensor imaging were obtained before and after 4 months of PAP-therapy...
November 2, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29101850/microrna-146a-promotes-ige-class-switch-in-b-cells-via-upregulating-14-3-3%C3%AF-expression
#6
Fei Li, Yi Huang, You-Ying Huang, Yan-Song Kuang, Yong-Jian Wei, Li Xiang, Xing-Ju Zhang, Zheng-Cai Jia, Shan Jiang, Jing-Yi Li, Ying Wan
B cells play a critical role in immune responses both in physiological and pathological conditions, and microRNAs have been shown to play important roles in regulating B cell proliferation and function. MiR-146a has been shown to modulate T cell immunity, but its function in regulating B cell response remains partially understood. Our previous studies indicated that germinal center (GC) B cells are significantly expanded in miR-146a-overexpressing (TG) mice. In this study, we further characterized the roles of miR-146a in regulating humoral immune responses to specific antigens...
November 1, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29098565/immunodeficiency-in-bloom-s-syndrome
#7
Michiel H D Schoenaker, Stefanie S Henriet, Jip Zonderland, Marcel van Deuren, Qiang Pan-Hammarström, Sandra J Posthumus-van Sluijs, Ingrid Pico-Knijnenburg, Corry M R Weemaes, Hanna IJspeert
Bloom's syndrome (BS) is an autosomal recessive disease, caused by mutations in the BLM gene. This gene codes for BLM protein, which is a helicase involved in DNA repair. DNA repair is especially important for the development and maturation of the T and B cells. Since BLM is involved in DNA repair, we aimed to study if BLM deficiency affects T and B cell development and especially somatic hypermutation (SHM) and class switch recombination (CSR) processes. Clinical data of six BS patients was collected, and immunoglobulin serum levels were measured at different time points...
November 2, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29089432/the-csr-system-regulates-escherichia-coli-fitness-by-controlling-glycogen-accumulation-and-energy-levels
#8
Manon Morin, Delphine Ropers, Eugenio Cinquemani, Jean-Charles Portais, Brice Enjalbert, Muriel Cocaign-Bousquet
In the bacterium Escherichia coli, the posttranscriptional regulatory system Csr was postulated to influence the transition from glycolysis to gluconeogenesis. Here, we explored the role of the Csr system in the glucose-acetate transition as a model of the glycolysis-to-gluconeogenesis switch. Mutations in the Csr system influence the reorganization of gene expression after glucose exhaustion and disturb the timing of acetate reconsumption after glucose exhaustion. Analysis of metabolite concentrations during the transition revealed that the Csr system has a major effect on the energy levels of the cells after glucose exhaustion...
October 31, 2017: MBio
https://www.readbyqxmd.com/read/29082655/immediately-restored-full-arch-fixed-prosthesis-on-implants-placed-in-both-healed-and-fresh-extraction-sockets-after-computer-planned-flapless-guided-surgery-a-3-year-follow-up-study
#9
Giampiero Ciabattoni, Alessandro Acocella, Roberto Sacco
BACKGROUND: The treatment of patients by the use of immediate implant placement in post-extractive site is a challenging procedure. PURPOSE: A 3-year clinical and radiological study of post-extractive implants placed using flapless guided surgery and immediately functioning. MATERIALS AND METHODS: Thirty-two patients (23 females and 9 males), aged between 44 and 73 years (a mean age of 59.5) were treated with immediate full arch restorations and flapless implant surgery in fresh extraction and healed sites...
October 29, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29080214/transcription-factor-yy1-can-control-aid-mediated-mutagenesis-in-mice
#10
Kristina Zaprazna, Arindam Basu, Nikola Tom, Vibha Jha, Suchita Hodawadekar, Lenka Radova, Jitka Malcikova, Boris Tichy, Sarka Pospisilova, Michael L Atchison
Activation-induced cytidine deminase (AID) is crucial for controlling the immunoglobulin (Ig) diversification processes of somatic hypermutation (SHM) and class switch recombination (CSR). AID initiates these processes by deamination of cytosine, ultimately resulting in mutations or double strand DNA breaks needed for SHM and CSR. Levels of AID control mutation rates, and off-target non-Ig gene mutations can contribute to lymphomagenesis. Therefore, factors that control AID levels in the nucleus can regulate SHM and CSR, and may contribute to disease...
October 28, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29078815/study-protocol-incentives-for-increased-access-to-comprehensive-family-planning-for-urban-youth-using-a-benefits-card-in-uganda-a-quasi-experimental-study
#11
Afra Nuwasiima, Elly Nuwamanya, Patricia Navvuga, Janet U Babigumira, Francis T Asiimwe, Solomon J Lubinga, Joseph B Babigumira
BACKGROUND: The use of contraception is one of the most cost-effective public health interventions and has the potential to prevent about 30% of maternal and 10% of child deaths in developing countries. Voucher-based initiatives for family planning are an effective and viable means of increasing contraceptive use. In this paper, we present a protocol for a pilot study of a novel incentive, a family planning benefits card (FPBC) program to increase uptake of family planning services among urban poor youth in Uganda while leveraging private sector funding...
October 27, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29077036/ultra-thin-multi-band-polarization-insensitive-microwave-metamaterial-absorber-based-on-multiple-order-responses-using-a-single-resonator-structure
#12
Yong Zhi Cheng, Zheng Ze Cheng, Xue Song Mao, Rong Zhou Gong
We design an ultra-thin multi-band polarization-insensitive metamaterial absorber (MMA) using a single circular sector resonator (CSR) structure in the microwave region. Simulated results show that the proposed MMA has three distinctive absorption peaks at 3.35 GHz, 8.65 GHz, and 12.44 GHz, with absorbance of 98.8%, 99.7%, and 98.3%, respectively, which agree well with an experiment. Simulated surface current distributions of the unit-cell structure reveal that the triple-band absorption mainly originates from multiple-harmonic magnetic resonance...
October 27, 2017: Materials
https://www.readbyqxmd.com/read/29076466/-a-supraorbital-trans-eyebrow-approach-in-surgery-of-chiasmatic-sellar-and-anterior-cranial-fossa-tumors
#13
A G Alekseev, A A Pichugin, V I Danilov
OBJECTIVE: to analyze 31 resections of chiasmatic-sellar region (CSR) and anterior cranial fossa (ACF) tumors using the supraorbital trans-eyebrow approach (STA). MATERIAL AND METHODS: We analyzed medical histories of 31 patients who underwent tumor resection using STA in the period between October 2013 and April 2017. We analyzed the age and gender of patients, size and location of the tumor, presence of a neurological deficit, vision and olfactory functions before and after surgery, surgery duration, amount of intraoperative blood loss, rate of frontal sinus trephination and nasal liquorrhea, hemorrhagic and ischemic complications after surgery, Simpson grade of tumor resection, patient's condition before and after surgery (Glasgow Outcome Scale and Karnofsky Scale), and degree of patient satisfaction with the cosmetic result of surgery...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29065956/distinct-patterns-of-hyperpnea-during-cheyne-stokes-respiration-implication-for-cardiac-function-in-patients-with-heart-failure
#14
Elisa Perger, Toru Inami, Owen D Lyons, Hisham Alshaer, Stephanie Smith, John S Floras, Alexander G Logan, Michael Arzt, Joaquin Duran Cantolla, Diego Delgado, Michael Fitzpatrick, John Fleetham, Takatoshi Kasai, R John Kimoff, Richard S T Leung, Geraldo Lorenzi Filho, Pierre Mayer, Lisa Mielniczuk, Debra L Morrison, Gianfranco Parati, Sairam Parthasarathy, Stefania Redolfi, Clodagh M Ryan, Frederic Series, George A Tomlinson, Anna Woo, T Douglas Bradley
STUDY OBJECTIVES: In heart failure (HF), we observed two patterns of hyperpnea during Cheyne-Stokes respiration with central sleep apnea (CSR-CSA): a positive pattern where end-expiratory lung volume remains at or above functional residual capacity, and a negative pattern where it falls below functional residual capacity. We hypothesized the negative pattern is associated with worse HF. METHODS: Patients with HF underwent polysomnography. During CSR-CSA, hyperpnea, apnea-hyperpnea cycle, and lung to finger circulation times (LFCT) were measured...
October 18, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29060172/monitoring-of-nocturnal-central-sleep-apnea-in-heart-failure-patients-using-noncontact-respiratory-differences
#15
Rami N Khushaba, Jeff Armitstead, Klaus Schindhelm
Monitoring of respiration patterns allows the early detection of various breathing disorders and may better identify those at risk for adverse acute outcomes in a variety of clinical settings. In this paper, we report on the use of SleepMinder (SM), a bedside non-contact Doppler-based biomotion recording sensor, to monitor remotely the nocturnal respiration patterns of 50 patients with systolic Heart failure (HF) while undergoing a lab based Polysomnography (PSG) test. A new respiration rate (RR) monitoring algorithm was developed based on the collected overnight radar signals...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29052558/cesarean-section-rate-in-singleton-primiparae-and-related-factors-in-beijing-china
#16
Geng Song, Yu-Mei Wei, Wei-Wei Zhu, Hui-Xia Yang
BACKGROUND: The cesarean section rate (CSR) has been a main concern worldwide. The present study aimed to investigate the CSR in Beijing, China, and to analyze the related factors of CS delivery. METHODS: An observational study was conducted in 15 medical centers in Beijing using a systemic cluster sampling method. In total, 15,194 pregnancies were enrolled in the study between June 20, 2013 and November 30, 2013. Independent t-tests and Pearson's Chi-square test were used to examine differences between two groups, and related factors of the CSR were examined by multivariable logistic regression...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29045727/short-term-thermal-photosynthetic-responses-of-c4-grasses-are-independent-of-the-biochemical-subtype
#17
Balasaheb V Sonawane, Robert E Sharwood, Susanne von Caemmerer, Spencer M Whitney, Oula Ghannoum, Christine Raines
C4 photosynthesis evolved independently many times, resulting in multiple biochemical pathways; however, little is known about how these different pathways respond to temperature. We investigated the photosynthetic responses of eight C4 grasses belonging to three biochemical subtypes (NADP-ME, PEP-CK, and NAD-ME) to four leaf temperatures (18, 25, 32, and 40 °C). We also explored whether the biochemical subtype influences the thermal responses of (i) in vitro PEPC (Vpmax) and Rubisco (Vcmax) maximal activities, (ii) initial slope (IS) and CO2-saturated rate (CSR) derived from the A-Ci curves, and (iii) CO2 leakage out of the bundle sheath estimated from carbon isotope discrimination...
October 16, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29042055/mechanism-underlying-the-suppressor-activity-of-retinoic-acid-on-il4-induced-ige-synthesis-and-its-physiological-implication
#18
Goo-Young Seo, Jeong-Min Lee, Young-Saeng Jang, Seung Goo Kang, Sung-Il Yoon, Hyun-Jeong Ko, Geun-Shik Lee, Seok-Rae Park, Cathryn R Nagler, Pyeung-Hyeun Kim
The present study extends an earlier report that retinoic acid (RA) down-regulates IgE Ab synthesis in vitro. Here, we show the suppressive activity of RA on IgE production in vivo and its underlying mechanisms. We found that RA down-regulated IgE class switching recombination (CSR) mainly through RA receptor α (RARα). Additionally, RA inhibited histone acetylation of germ-line ε (GL ε) promoter, leading to suppression of IgE CSR. Consistently, serum IgE levels were substantially elevated in vitamin A-deficient (VAD) mice and this was more dramatic in VAD-lecithin:retinol acyltransferase deficient (LRAT(-/-)) mice...
October 3, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28994753/genome-wide-analysis-of-hdac-inhibitor-mediated-modulation-of-micrornas-and-mrnas-in-b-cells-induced-to-undergo-class-switch-dna-recombination-and-plasma-cell-differentiation
#19
Helia N Sanchez, Tian Shen, Dawn Garcia, Zhao Lai, Paolo Casali, Hong Zan
Antibody responses are accomplished through several critical B cell-intrinsic processes, including somatic hypermutation (SHM), class-switch DNA recombination (CSR), and plasma cell differentiation. In recent years, epigenetic modifications or factors, such as histone deacetylation and microRNAs (miRNAs), have been shown to interact with B-cell genetic programs to shape antibody responses, while the dysfunction of epigenetic factors has been found to lead to autoantibody responses. Analyzing genome-wide miRNA and mRNA expression in B cells in response to epigenetic modulators is important for understanding the epigenetic regulation of B-cell function and antibody response...
September 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28982036/do-individuals-respond-to-cost-sharing-subsidies-in-their-selections-of-marketplace-health-insurance-plans
#20
Thomas DeLeire, Andre Chappel, Kenneth Finegold, Emily Gee
The Affordable Care Act (ACA) provides assistance to low-income consumers through both premium subsidies and cost-sharing reductions (CSRs). Low-income consumers' lack of health insurance literacy or information regarding CSRs may lead them to not take-up CSR benefits for which they are eligible. We use administrative data from 2014 to 2016 on roughly 22 million health insurance plan choices of low-income individuals enrolled in ACA Marketplace coverage to assess whether they behave in a manner consistent with being aware of the availability of CSRs...
September 20, 2017: Journal of Health Economics
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