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https://www.readbyqxmd.com/read/27902664/team-based-learning-improves-staff-nurses-knowledge-of-open-and-closed-chest-cardiac-surgical-resuscitation
#1
Marion E McRae, Alice Chan, Ai Jin Lee, Renee Hulett, Bernice Coleman
BACKGROUND: There are few reports of the use of 1-session team-based learning (TBL) in hospital settings and none to teach cardiac surgical resuscitation (CSR). OBJECTIVE: The aim of this study was to investigate whether 1-session TBL is an effective method to increase nursing knowledge of CSR. METHODS: The participating subjects viewed a PowerPoint presentation about CSR prior to the learning session. Participants completed a 16-item individual readiness assessment test...
January 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/27902421/domain-evolution-in-enzymes-of-the-neopullulanase-subfamily
#2
Andrea Kuchtova, Stefan Janecek
Among the glycoside hydrolases (GHs) classified within the CAZy database, the α-amylase family GH13 containing ~30 different enzyme specificities and more than 37,000 sequences, represents one of the largest GH families. Earlier, based on a characteristic sequence motif in their 5th conserved sequence region (CSR), the two closely related subfamilies, the so-called oligo-1,6-glucosidase and neopullulanase subfamilies were described. Currently the two subfamilies cover several CAZy-defined GH13 subfamilies because the α-amylase family GH13 has officially been divided into 41 subfamilies...
November 1, 2016: Microbiology
https://www.readbyqxmd.com/read/27897229/global-gene-regulation-during-activation-of-immunoglobulin-class-switching-in-human-b-cells
#3
Youming Zhang, David J Fear, Saffron A G Willis-Owen, William O Cookson, Miriam F Moffatt
Immunoglobulin class switch recombination (CSR) to IgE is a tightly regulated process central to atopic disease. To profile the B-cell transcriptional responses underlying the activation of the germinal centre activities leading to the generation of IgE, naïve human B-cells were stimulated with IL-4 and anti-CD40. Gene expression and alternative splicing were profiled over 12 days using the Affymetrix Human Exon 1.0 ST Array. A total of 1,399 genes, forming 13 temporal profiles were differentially expressed...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896626/cheyne-stokes-respiration-during-wakefulness-in-patients-with-chronic-heart-failure
#4
Wolfram Grimm, Karl Kesper, Werner Cassel, Nina Timmesfeld, Olaf Hildebrandt, Ulrich Koehler
PURPOSE: Cheyne-Stokes respiration (CSR) during sleep has been studied extensively in patients with chronic heart failure (CHF). Prevalence and prognostic significance of CSR during wakefulness in CHF, however, are largely unknown. METHODS: CSR during wakefulness with an apnea-hypopnea cut-off ≥5/h and moderate to severe CSR with an apnea-hypopnea cutoff ≥15/h were analyzed using polysomnographic recordings in 267 patients with stable CHF with reduced left ventricular (LV) ejection fraction at our institution...
November 28, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27872163/role-of-autophagy-in-cadmium-induced-testicular-injury
#5
Y-J Wang, J Yan, F Yin, L Li, Y-G Qin, C-Y Meng, R-F Lu, L Guo
The testis is sensitive to cadmium, but studies investigating cadmium-induced testicular injury have not yet clearly revealed the underlying mechanisms. This study aimed to investigate the injurious effects of cadmium on rat testes and the role that autophagy plays in this process. Wistar rats were randomly divided into four groups and intraperitoneally injected with 0.2 (low), 0.4 (middle), and 0.8 mg/kg·body weight (high) cadmium chloride for 5 weeks, while the control rats were injected with equal volume of saline...
November 21, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27864641/an-open-prospective-single-cohort-multicenter-study-evaluating-the-novel-tapered-conical-connection-implants-supporting-single-crowns-in-the-anterior-and-premolar-maxilla-interim-1-year-results
#6
Alexander Fügl, Werner Zechner, Alessandro Pozzi, Guido Heydecke, Christine Mirzakhanian, Nikolaus Behneke, Alexandra Behneke, Russell A Baer, Robert Nölken, Edward Gottesman, Snjezana Colic
OBJECTIVES: The aim of this multicenter prospective clinical study was to evaluate anodized tapered implants with a conical connection and integrated platform shifting placed in the anterior and premolar maxilla. MATERIALS AND METHODS: The study enrolled patients requiring single-tooth restorations in healed sites of maxillary anterior and premolar teeth. All implants were immediately temporized. Clinical and radiographic evaluations were conducted at implant insertion, 6 months, and 1 year...
November 18, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27863316/is-the-war-really-over-a-20-year-longitudinal-study-on-trajectories-of-suicidal-ideation-and-posttraumatic-stress-symptoms-following-combat
#7
Avigal Snir, Yossi Levi-Belz, Zahava Solomon
Combat stress reaction (CSR) has widespread long-term consequences, including profound psychopathology in the form of posttraumatic stress disorder (PTSD). Studies have established the link between combat, PTSD, and suicidality. However, little is known about the temporal course of suicidal ideation (SI) in general, specifically among war veterans. We aimed to trace the trajectories of SI in the aftermath of war and to explore the role of CSR and PTSD in SI trajectories. Israeli veterans with CSR (n=164) and a matched control group (NCSR, n=111) were assessed, using self-report measures at three points over the course of 20 years...
November 1, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27854362/a-bayesian-cluster-analysis-method-for-single-molecule-localization-microscopy-data
#8
Juliette Griffié, Michael Shannon, Claire L Bromley, Lies Boelen, Garth L Burn, David J Williamson, Nicholas A Heard, Andrew P Cope, Dylan M Owen, Patrick Rubin-Delanchy
Cell function is regulated by the spatiotemporal organization of the signaling machinery, and a key facet of this is molecular clustering. Here, we present a protocol for the analysis of clustering in data generated by 2D single-molecule localization microscopy (SMLM)-for example, photoactivated localization microscopy (PALM) or stochastic optical reconstruction microscopy (STORM). Three features of such data can cause standard cluster analysis approaches to be ineffective: (i) the data take the form of a list of points rather than a pixel array; (ii) there is a non-negligible unclustered background density of points that must be accounted for; and (iii) each localization has an associated uncertainty in regard to its position...
December 2016: Nature Protocols
https://www.readbyqxmd.com/read/27854123/a-retrospective-analysis-of-cardiovascular-outcomes-in-patients-treated-with-asv
#9
Arild Hetland, Kristina H Haugaa, Maria Vistnes, Kristian Hovde Liland, Margareth Olseng, Morten B Jacobsen, Thor Edvardsen
Objectives- The effect of long term adaptive servo-ventilation (ASV) on cardiovascular mortality and admission rates in patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR) has not been much studied. The aim of this study was primarily to investigate whether ASV therapy significantly reduced these parameters. Design- We included 75 CHF patients on optimal medication and CSR ≥25% of sleeping time, in New York Heart Association (NYHA) class II-IV and left ventricular ejection fraction (LVEF) ≤ 45%...
November 17, 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27853268/kin17-facilitates-multiple-double-strand-break-repair-pathways-that-govern-b-cell-class-switching
#10
Michael X Le, Dania Haddad, Alexanda K Ling, Conglei Li, Clare C So, Amit Chopra, Rui Hu, Jaime F Angulo, Jason Moffat, Alberto Martin
Class switch recombination (CSR) in B cells requires the timely repair of DNA double-stranded breaks (DSBs) that result from lesions produced by activation-induced cytidine deaminase (AID). Through a genome-wide RNAi screen, we identified Kin17 as a gene potentially involved in the maintenance of CSR in murine B cells. In this study, we confirm a critical role for Kin17 in CSR independent of AID activity. Furthermore, we make evident that DSBs generated by AID or ionizing radiation require Kin17 for efficient repair and resolution...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27845410/the-rna-binding-protein-csra-plays-a-central-role-in-positively-regulating-virulence-factors-in-erwinia-amylovora
#11
Veronica Ancona, Jae Hoon Lee, Youfu Zhao
The GacS/GacA two-component system (also called GrrS/GrrA) is a global regulatory system which is highly conserved among gamma-proteobacteria. This system positively regulates non-coding small regulatory RNA csrB, which in turn binds to the RNA-binding protein CsrA. However, how GacS/GacA-Csr system regulates virulence traits in E. amylovora remains unknown. Results from mutant characterization showed that the csrB mutant was hypermotile, produced higher amount of exopolysaccharide amylovoran, and had increased expression of type III secretion (T3SS) genes in vitro...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27843240/choroidal-melanoma-masquerading-as-multifocal-central-serous-chorioretinopathy
#12
Pukhraj Rishi, Ramya Appanraj, Tarun Sharma
A 56 year-old-male presented with diminution of vision in right eye of 2 months duration. His best corrected visual acuity (BCVA) was 20/25. Anterior segment examination was bilaterally normal. Right fundus revealed oval, raised, pigmented lesion in superotemporal quadrant with subfoveal fluid. Fundus fluroscein angiography (FFA) showed multiple pinpoint leakages. Acoustic hollowing on ultrasound (USG) was typical of choroidal melanoma. A high index of suspicion is required for the diagnosis of small choroidal melanoma that could present with multiple focal leaks and subretinal fluid simulating multifocal central serous retinopathy (CSR)...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27836828/the-cataract-situation-in-suriname-an-effective-intervention-programme-to-increase-the-cataract-surgical-rate-in-a-developing-country
#13
Jerrel C Pawiroredjo, Janna Minderhoud, Dennis R A Mans, Herman C I Themen, Anne-Marie T Bueno de Mesquita-Voigt, Michael R Siban, Cindy M Forster-Pawiroredjo, Annette C Moll, Ruth M A van Nispen, Hans Limburg
AIMS: To provide an overview of cataract data in Suriname and to describe and evaluate a programme to control cataract blindness in a developing country. DESIGN: Evaluation of hospital data and findings from a population-based cross-sectional survey. METHODS: The implementation of a new cataract surgical intervention programme was described and retrospectively evaluated by analysing the number of cataract operations and other related indicators at the Suriname Eye Centre (SEC) in the period 2006-2014...
November 11, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27836054/clinical-phenotypes-of-hyper-igm-syndromes
#14
M Teresa de la Morena
The primary immunodeficiency (PID) diseases comprise a heterogeneous group of inherited disorders of immune function. Technical advancements in whole-genome, whole-exome, and RNA-sequencing have seen the explosion of genetic discoveries in the field of PIDs. The present review aims to focus on a group of immunodeficiency disorders associated with elevated levels of IgM (hyper IgM; HIGM) and provides a clinical differential diagnosis. Most patients present for evaluation of immunodeficiency due to recurrent infections, and laboratory studies show either a clear isolated elevation of serum immunoglobulin M (IgM) with low or absent IgG, IgA, and IgE...
November 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27835756/regulated-localization-of-an-aid-complex-with-e2a-pax5-and-irf4-at-the-igh-locus
#15
Jannek Hauser, Christine Grundström, Ramesh Kumar, Thomas Grundström
Activation-induced cytidine deaminase (AID) is the key mutagenic enzyme that initiates somatic hypermutation (SH) and class switch recombination (CSR) by deaminating cytosine to uracil. The targeting of AID and therefore SH and CSR to Ig genes is a central process of the immune system, but the trans-acting factors mediating the specific targeting have remained elusive. Here we show that defective calmodulin inhibition of the transcription factor E2A after activation of the B cell receptor (BCR) leads to reduced BCR, IL4 plus CD40 ligand stimulated CSR to IgE and instead CSR to other Ig classes...
November 8, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27827407/the-aca%C3%A2-s-cost-sharing-reduction-plans-a-key-to-affordable-health-coverage-for-millions-of-u-s-workers
#16
Jon Gabel, Heidi Whitmore, Matthew Green, Adrienne Call, Sam Stromberg, Rebecca Oran
Issue: Without the cost-sharing reductions (CSRs) made available by the Affordable Care Act, health plans sold in the marketplaces may be unaffordable for many lowincome people. CSRs are available to households earning between 100 percent and 250 percent of the federal poverty level that choose a silver-level marketplace plan. In 2016, about 7 million people received cost-sharing reductions that substantially lowered their deductibles, copayments, coinsurance, and out-of-pocket limits. Goal: To examine variations in consumer cost-sharing reductions between silver-level plans with CSRs to traditional marketplace plans and to employer-based insurance...
October 2016: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/27824972/single-implant-survival-more-than-30-years-of-clinical-experience
#17
Torsten Jemt
PURPOSE: The aim of this study was to report long-term clinical survival of single implants provided with turned and moderately rough surfaces in routine practice. MATERIALS AND METHODS: All patients consecutively treated at a specialist center with single-crown implants from 1982 to 2013 were included. For all these patients, data on implant failure and last examination at the clinic were collected, and thereafter cumulative survival rates (CSR) were calculated for patients treated in the maxilla or mandible with turned or moderately rough surfaces, respectively...
November 2016: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/27819773/prognosis-of-thymectomy-in-myasthenia-gravis-patients-with-thymus-hyperplasia
#18
Jing Yang, Chanchan Liu, Tao Li, Chengyan Li
PURPOSE: To compare the post-thymectomy prognosis in different conditions of myasthenia gravis (MG) patients with thymus hyperplasia. MATERIALS AND METHODS: Collecting medical record and carrying out the follow-up study of one hundred and twenty three myasthenia gravis patients with thymus hyperplasia who have underwent thymectomy during the period between 2003 and 2013. Dividing into different groups based on gender, age of onset, duration of disease and Myasthenia Gravis Association of America (MGFA) clinical classification to analyze different prognosis in different groups...
November 7, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27819710/transparency-of-chemical-risk-assessment-data-under-reach
#19
Ellen Ingre-Khans, Marlene Ågerstrand, Anna Beronius, Christina Rudén
The REACH regulation requires EU manufacturers and importers of substances to register information on the hazard and risk of their substances with the European Chemicals Agency (ECHA). Risk management of the substances is based on the provided information. It is known that conclusions on hazard and risk are influenced by expert judgements as well as potential conflict of interests. Thus, it is important that hazard and risk assessments are transparent and can be evaluated by a third party. The aim of this study is to scrutinize the transparency, i...
November 7, 2016: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/27818991/percutaneous-device-to-narrow-the-coronary-sinus-shifting-paradigm-in-the-treatment-of-refractory-angina-a-review-of-the-literature
#20
Daniela Benedetto, Masieh Abawi, Pieter R Stella, Freek Nijhoff, Maxime D M Lakemeier, Friso Kortlandt, Pieter A Doevendans, Pierfrancesco Agostoni
Refractory angina pectoris is defined as a chronic debilitating condition characterized by the presence of chronic anginal symptoms due to a severe obstructive and/or diffuse coronary artery disease that cannot be controlled by the combination of medical therapy and/or revascularization (percutaneous or surgical). In addition, the presence of myocardial ischemia as a cause of the symptoms must have been documented. The coronary sinus reducer (CSR) is a recently introduced percutaneous device to treat patients with severe anginal symptoms refractory to optimal medical therapy and not amenable to conventional revascularization...
2016: Frontiers in Cardiovascular Medicine
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