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https://www.readbyqxmd.com/read/28801586/identification-of-mega-environments-and-rice-genotypes-for-general-and-specific-adaptation-to-saline-and-alkaline-stresses-in-india
#1
S L Krishnamurthy, P C Sharma, D K Sharma, K T Ravikiran, Y P Singh, V K Mishra, D Burman, B Maji, S Mandal, S K Sarangi, R K Gautam, P K Singh, K K Manohara, B C Marandi, G Padmavathi, P B Vanve, K D Patil, S Thirumeni, O P Verma, A H Khan, S Tiwari, S Geetha, M Shakila, R Gill, V K Yadav, S K B Roy, M Prakash, J Bonifacio, Abdelbagi Ismail, G B Gregorio, Rakesh Kumar Singh
In the present study, a total of 53 promising salt-tolerant genotypes were tested across 18 salt-affected diverse locations for three years. An attempt was made to identify ideal test locations and mega-environments using GGE biplot analysis. The CSSRI sodic environment was the most discriminating location in individual years as well as over the years and could be used to screen out unstable and salt-sensitive genotypes. Genotypes CSR36, CSR-2K-219, and CSR-2K-262 were found ideal across years. Overall, Genotypes CSR-2K-219, CSR-2K-262, and CSR-2K-242 were found superior and stable among all genotypes with higher mean yields...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800755/the-influence-of-3%C3%A2-months-of-physical-exercises-and-verbal-stimulation-on-functional-efficiency-and-use-of-free-time-in-an-older-population-under-institutional-care-study-protocol-for-a-randomized-controlled-trial
#2
Agnieszka Wiśniowska-Szurlej, Agnieszka Ćwirlej-Sozańska, Anna Wilmowska-Pietruszyńska, Natalia Milewska, Bernard Sozański
BACKGROUND: In recent years, there has been a significant change in the demographics of developed countries, including an increase in the number of older people. This aging population and the associated need for medical care and assistance places great strain on health care systems worldwide. In older populations, improved knowledge and understanding of the relationship between moderate exercise and health might result in greater motivation to engage in such activity; thus improving the overall health of this population...
August 11, 2017: Trials
https://www.readbyqxmd.com/read/28796489/rational-modular-rna-engineering-based-on-in-vivo-profiling-of-structural-accessibility
#3
Abigail N Leistra, Paul Amador, Aishwarya Buvanendiran, Alex Moon-Walker, Lydia M Contreras
Bacterial small RNAs (sRNAs) have been established as powerful parts for controlling gene expression. However, development and application of engineered sRNAs has primarily focused on regulating novel synthetic targets. In this work, we demonstrate a rational modular RNA engineering approach that uses in vivo structural accessibility measurements to tune the regulatory activity of a multisubstrate sRNA for differential control of its native target network. Employing the CsrB global sRNA regulator as a model system, we use published in vivo structural accessibility data to infer the contribution of its local structures (substructures) to function and select a subset for engineering...
August 10, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28795591/in-vivo-measurement-of-tri-axial-loading-at-the-head-during-the-rugby-tackle
#4
Ross Jones, Matt Greig
To investigate the anatomical distribution of linear and rotational forces during the tackle scenario, male rugby players performed a total of 48 trials, as ball carrier or tackler. Participants wore headgear accommodating three global positioning system units measuring uniaxial acceleration at the occipital region (OR), left tempero-parietal (LT-PR) and right tempero-parietal region (RT-PR). An additional unit was located at the cervico-thoracic spinal region in a custom vest. There was a significant main effect for tackle condition (P < 0...
August 10, 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/28790320/activation-induced-cytidine-deaminase-targets-suv4-20-mediated-histone-h4k20-trimethylation-to-class-switch-recombination-sites
#5
Virginia C Rodríguez-Cortez, Paloma Martínez-Redondo, Francesc Català-Moll, Javier Rodríguez-Ubreva, Antonio Garcia-Gomez, Ganesh Poorani-Subramani, Laura Ciudad, Henar Hernando, Arantxa Pérez-García, Carlos Company, José M Urquiza, Almudena R Ramiro, Javier M Di Noia, Alejandro Vaquero, Esteban Ballestar
Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID in epigenetic regulation. AID is mutated in hyper-IgM type 2 (HIGM2) syndrome. Here, we investigated the potential role of AID in the acquisition of epigenetic changes. We discovered that AID binding to the IgH locus promotes an increase in H4K20me3...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28777947/aid-invited-to-the-g4-summit
#6
Joseph N Pucella, Jayanta Chaudhuri
In this issue of Molecular Cell, Qiao et al. (2017) use both biochemical and structural approaches to report AID-preferred nucleic acid substrates, illuminating AID targeting mechanisms during CSR and SHM.
August 3, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28777017/how-to-take-arms-against-central-apneas-in-heart-failure
#7
Chiara Borrelli, Alberto Aimo, Gianluca Mirizzi, Claudio Passino, Giuseppe Vergaro, Michele Emdin, Alberto Giannoni
Introduction Despite being a risk mediator in several observational studies, central apneas are currently orphan of treatment in heart failure. After the neutral effects on survival of two randomized controlled trials (RCTs) based on the use of positive airway pressure (the CANPAP and SERVE-HF trials), two alternative hypotheses have been formulated: 1) Periodic breathing/Cheyne-Stokes respiration (PB/CSR) in HF is protective. Indeed, the Naughton's hypothesis assumes that hyperventilation leads to increased cardiac output, lung volume, oxygen storage and reduced muscle sympathetic nerve activity and central apnea to respiratory muscle rest and hypoxia-induced erythropoiesis...
August 4, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28757211/aid-recognizes-structured-dna-for-class-switch-recombination
#8
Qi Qiao, Li Wang, Fei-Long Meng, Joyce K Hwang, Frederick W Alt, Hao Wu
Activation-induced cytidine deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. Mechanisms of AID targeting and catalysis remain elusive despite its critical immunological roles and off-target effects in tumorigenesis. Here, we produced active human AID and revealed its preferred recognition and deamination of structured substrates. G-quadruplex (G4)-containing substrates mimicking the mammalian immunoglobulin switch regions are particularly good AID substrates in vitro...
August 3, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28756415/cognitive-behavioural-therapy-and-return-to-work-intervention-for-patients-on-sick-leave-due-to-common-mental-disorders-a-randomised-controlled-trial
#9
Sigrid Salomonsson, Fredrik Santoft, Elin Lindsäter, Kersti Ejeby, Brjánn Ljótsson, Lars-Göran Öst, Martin Ingvar, Mats Lekander, Erik Hedman-Lagerlöf
OBJECTIVES: Common mental disorders (CMDs) cause great individual suffering and long-term sick leave. Cognitive-behavioural therapy (CBT) effectively treats CMDs, but sick leave is not reduced to the same extent as psychiatric symptoms. Research results regarding return-to-work interventions (RTW-Is) and their effect on sick leave are inconclusive. The aim of this study was to evaluate CBT, a RTW-I and combined CBT and RTW-I (COMBO) for primary care patients on sick leave due to CMDs...
July 29, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28754858/melphalan-modifies-the-bone-microenvironment-by-enhancing-osteoclast-formation
#10
Ryan C Chai, Michelle M McDonald, Rachael L Terry, Nataša Kovačić, Jenny M Down, Jessica A Pettitt, Sindhu T Mohanty, Shruti Shah, Gholamreza Haffari, Jiake Xu, Matthew T Gillespie, Michael J Rogers, John T Price, Peter I Croucher, Julian M W Quinn
Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor development. Dormant MM cells can be reactivated after melphalan treatment; however, it is unclear whether melphalan treatment increases osteoclast formation to modify the endosteal niche.Melphalan treatment of mice for 14 days decreased bone volume and the endosteal bone surface, and this was associated with increases in osteoclast numbers...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28751913/cumulative-success-rate-of-short-and-ultrashort-implants-supporting-single-crowns-in-the-posterior-maxilla-a-3-year-retrospective-study
#11
Giorgio Lombardo, Jacopo Pighi, Mauro Marincola, Giovanni Corrocher, Miguel Simancas-Pallares, Pier Francesco Nocini
AIM: To determine cumulative success rate (CSR) of short and ultrashort implants in the posterior maxilla restored with single crowns. PATIENTS AND METHODS: We performed a retrospective study in 65 patients with 139 implants. 46 were ultrashort and 93 short. Implants were placed with a staged approach and restored with single crowns. Success rate, clinical and radiographic outcomes, and crown-to-implant ratio (CIR) were assessed after three years. Statistical analysis was performed by descriptive and inferential statistics...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28736352/the-effect-of-biocomposite-screws-on-bone-regeneration-in-a-rat-osteoporosis-model
#12
Je Hoon Jeong, Eun-Sun Jin, Ji Yeon Kim, Bora Lee, JoongKee Min, Sang Ryong Jeon, Minsu Lee, Kyoung Hyo Choi
INTRODUCTION: The aim of this study was to evaluate the efficacy of biocomposite screws used in ovariectomy (OVX) induced osteoporotic rats. METHODS: Twenty-four female Wistar rats (250-300g, 12 weeks old) were divided into 4 groups; Sham group (control), OVX-induced osteoporosis group (OVX), OVX and biodegradable (PLGA (poly-lactic-co-glycolic acid) without ß-TCP (tricalcium phosphate) screw insertion group (OVX/BSR), OVX and biocomposite (PLGA with ß-TCP) screw insertion group (OVX/CSR)...
July 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735018/safety-and-feasibility-of-direct-mri-guided-transperineal-prostate-biopsy-using-a-novel-mri-safe-robotic-device
#13
Mark W Ball, Ashley E Ross, Kamyar Ghabili, Chunwoo Kim, Changhan Jun, Doru Petrisor, Li Pan, Jonathan I Epstein, Katarzyna J Macura, Dan S Stoianovici, Mohamad E Allaf
OBJECTIVE: To evaluate safety and feasibility in a first in human trial of direct MRI-guided prostate biopsy using a novel robotic device. METHODS: MrBot is an MRI-safe robotic device constructed entirely of nonconductive, nonmetallic, and nonmagnetic materials, developed by our group. A safety and feasibility clinical trial was designed to assess the safety and feasibility of direct MRI-guided biopsy with MrBot and determine its targeting accuracy. Men with elevated PSA, prior negative prostate biopsy and cancer suspicious region (CSR) on MRI were enrolled in the study...
July 19, 2017: Urology
https://www.readbyqxmd.com/read/28724724/brct-domain-protein-brit1-influences-class-switch-recombination
#14
Wei-Feng Yen, Ashutosh Chaudhry, Bharat Vaidyanathan, William T Yewdell, Joseph N Pucella, Rahul Sharma, Yulong Liang, Kaiyi Li, Alexander Y Rudensky, Jayanta Chaudhuri
DNA double-strand breaks (DSBs) serve as obligatory intermediates for Ig heavy chain (Igh) class switch recombination (CSR). The mechanisms by which DSBs are resolved to promote long-range DNA end-joining while suppressing genomic instability inherently associated with DSBs are yet to be fully elucidated. Here, we use a targeted short-hairpin RNA screen in a B-cell lymphoma line to identify the BRCT-domain protein BRIT1 as an effector of CSR. We show that conditional genetic deletion of BRIT1 in mice leads to a marked increase in unrepaired Igh breaks and a significant reduction in CSR in ex vivo activated splenic B cells...
July 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28713427/a-three-year-retrospective-study-on-survival-of-ceramic-veneered-zirconia-y-tzp-fixed-dental-prostheses-performed-in-private-practices
#15
Veronika Norström Saarva, Göran Bjerkstig, Anders Örtorp, Per Svanborg
OBJECTIVES: The aim of this retrospective study was to evaluate the three-year clinical outcome for ceramic-veneered zirconia fixed dental prostheses (FDPs). METHODS: All patients who were treated with ceramic-veneered zirconia FDPs, in three private practices in Sweden, during the period June 2003 to April 2007 were included. Case records from 151 patients, treated with a total of 184 zirconia FDPs (692 units), were analysed for clinical data. All complications noted in the charts were registered and compared to definitions for success and survival and statistical analysis was performed using the Kaplan-Meier method and a Cox regression model...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28711304/comparing-reach-chemical-safety-assessment-information-with-practice-a-case-study-of-polymethylmethacrylate-pmma-in-floor-coating-in-the-netherlands
#16
Ton Spee, Daan Huizer
On June 1st, 2007 the European regulation on Registration, Evaluation and Restriction of Chemical substances (REACH) came into force. Aim of the regulation is safe use of chemicals for humans and for the environment. The core element of REACH is chemical safety assessment of chemicals and communication of health and safety hazards and risk management measures throughout the supply chain. Extended Safety Data Sheets (Ext-SDS) are the primary carriers of health and safety information. The aim of our project was to find out whether the actual exposure to methyl methacrylate (MMA) during the application of polymethylmethacrylate (PMMA) in floor coatings as assessed in the chemical safety assessment, reflect the exposure situations as observed in the Dutch building practice...
June 4, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28708921/outcomes-assessment-of-treating-completely-edentulous-patients-with-a-fixed-implant-supported-profile-prosthesis-utilizing-a-graftless-approach-part-1-clinically-related-outcomes
#17
Fawaz Alzoubi, Edmond Bedrossian, Allen Wong, Douglas Farrell, Chan Park, Thomas Indresano
PURPOSE: To assess outcomes of treating completely edentulous patients with a fixed implant-supported profile prosthesis utilizing a graftless approach for the maxilla and for the mandible, with emphasis on clinically related outcomes, specifically implant and prosthesis survival. MATERIALS AND METHODS: This was a retrospective study with the following inclusion criteria: completely edentulous patients rehabilitated with a fixed implant-supported profile denture utilizing a graftless approach...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28695998/co-surgeons-in-breast-reconstructive-microsurgery-what-do-they-bring-to-the-table
#18
Nicholas T Haddock, Samar Kayfan, Ronnie A Pezeshk, Sumeet S Teotia
INTRODUCTION: Current research within other surgical specialties suggests that a co-surgeon approach may reduce operative times and complications associated with complex bilateral procedures, possibly leading to improved patient and surgical outcomes. We sought to evaluate the role of the co-surgery team and its development in free flap breast reconstruction. METHODS: A retrospective review of free-flap breast reconstruction by two surgeons from 2011 to 2016 was conducted...
July 11, 2017: Microsurgery
https://www.readbyqxmd.com/read/28693426/evolution-gene-expression-profiling-and-3d-modeling-of-csld-proteins-in-cotton
#19
Yanpeng Li, Tiegang Yang, Dandan Dai, Ying Hu, Xiaoyang Guo, Hongxia Guo
BACKGROUND: Among CESA-like gene superfamily, the cellulose synthase-like D (CSLD) genes are most similar to cellulose synthase genes and have been reported to be involved in tip-growing cell and stem development. However, there has been no genome-wide characterization of this gene subfamily in cotton. We thus sought to analyze the evolution and functional characterization of CSLD proteins in cotton based on fully sequenced cotton genomes. RESULTS: A total of 23 full-length CSLD proteins were identified in Gossypium raimondii, Gossypium arboreum and Gossypium hirsutum...
July 10, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28689860/the-expression-pattern-of-hsp70-plays-a-critical-role-in-thermal-tolerance-of-marine-demersal-fish-multilevel-responses-of-paralichthys-olivaceus-and-its-hybrids-p-%C3%A2-olivaceus-%C3%A2-%C3%A2-%C3%A3-p-%C3%A2-dentatus-%C3%A2-to-chronic-and-acute-heat-stress
#20
Yifan Liu, Daoyuan Ma, Chunyan Zhao, Zhizhong Xiao, Shihong Xu, Yongshuang Xiao, Yanfeng Wang, Qinghua Liu, Jun Li
Ocean warming has multifaceted impacts on marine organisms. This study investigated the different responses of Paralichthys olivaceus and the hybrids (P. olivaceus ♀ × P. dentatus ♂) to chronic and acute heat stress. By comparing their survival, behavioural and histological changes, we found that the hybrids possess a better thermal tolerance with a higher cumulative survival rate (CSR), relatively fewer behavioural changes and less gill damage. Moreover, we analysed the relationship between thermal tolerance and the hsp70 expression pattern and found that thermal tolerant species (the hybrids) exhibited higher threshold induction temperature, shorter durations, stronger magnitudes and a delay in hsp70 expression...
June 23, 2017: Marine Environmental Research
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