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https://www.readbyqxmd.com/read/28426321/hansae-vietnam-s-garment-factory-latest-example-of-how-corporate-social-responsibility-has-failed-to-protect-workers
#1
Garrett Brown
A Korean-operated garment factory complex in Vietnam was subject to 26 separate corporate social responsibility (CSR) audits in 2015. However, thorough inspections by two other non-governmental organizations in 2016 found numerous violations of Vietnamese occupational health and safety and labor laws as well as violations of the corporate codes of conduct of the international clothing brands which source apparel from the facility. The 2016 investigations indicate the lack of efficacy of the 2015 CSR audits and call into question whether voluntary CSR programs and audits by for-profit CSR monitoring companies can effectively protect the health, safety and legal rights of workers in global supply chains...
April 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28416602/antigen-receptor-galaxy-a-user-friendly-web-based-tool-for-analysis-and-visualization-of-t-and-b-cell-receptor-repertoire-data
#2
Hanna IJspeert, Pauline A van Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Andrew P Stubbs, Mirjam van der Burg
Antigen Receptor Galaxy (ARGalaxy) is a Web-based tool for analyses and visualization of TCR and BCR sequencing data of 13 species. ARGalaxy consists of four parts: the demultiplex tool, the international ImMunoGeneTics information system (IMGT) concatenate tool, the immune repertoire pipeline, and the somatic hypermutation (SHM) and class switch recombination (CSR) pipeline. Together they allow the analysis of all different aspects of the immune repertoire. All pipelines can be run independently or combined, depending on the available data and the question of interest...
April 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28416601/csreport-a-new-computational-tool-designed-for-automatic-analysis-of-class-switch-recombination-junctions-sequenced-by-high-throughput-sequencing
#3
François Boyer, Hend Boutouil, Iman Dalloul, Zeinab Dalloul, Jeanne Cook-Moreau, Jean-Claude Aldigier, Claire Carrion, Bastien Herve, Erwan Scaon, Michel Cogné, Sophie Péron
B cells ensure humoral immune responses due to the production of Ag-specific memory B cells and Ab-secreting plasma cells. In secondary lymphoid organs, Ag-driven B cell activation induces terminal maturation and Ig isotype class switch (class switch recombination [CSR]). CSR creates a virtually unique IgH locus in every B cell clone by intrachromosomal recombination between two switch (S) regions upstream of each C region gene. Amount and structural features of CSR junctions reveal valuable information about the CSR mechanism, and analysis of CSR junctions is useful in basic and clinical research studies of B cell functions...
April 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28407558/cd11b-regulates-antibody-class-switching-via-induction-of-aid
#4
Seohyun Park, Hyunsub Sim, Hye-In Kim, Daecheol Jeong, Guang Wu, Soo Young Cho, Young Seek Lee, Hyung-Joo Kwon, Keunwook Lee
The integrin CD11b, which is encoded by the integrin subunit alpha M (ITGAM), is primarily expressed on the surface of innate immune cells. Genetic variations in ITGAM are among the strongest risk factors for systemic lupus erythematosus, an autoimmune disease characterized by the presence of autoantibodies. However, the regulatory function of CD11b in the antibody responses remains unclear. Here, we report the induction of CD11b in activated B2 B cells and define its unexpected role in immunoglobulin heavy chain class switch recombination (CSR)...
April 10, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28398571/what-does-the-alcohol-industry-mean-by-responsible-drinking-a-comparative-analysis
#5
N Maani Hessari, M Petticrew
Background: The alcohol industry uses responsible drinking messaging as a central element of its corporate social responsibility (CSR) activities. It has been argued that such messaging is vague, and potentially part of broader CSR activities to protect industry interests at the expense of public health. This study aimed to identify how industry defines responsible drinking, and in what contexts it is used. Methods: This was a qualitative documentary analysis of publicly available documents and web pages, including company web pages, press releases, reports and blogs from a representative selection of alcohol producers, and industry social aspect/public relations organizations; these were compared to health NGOs and Public Health England...
April 7, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28388622/an-experimental-test-of-csr-theory-using-a-globally-calibrated-ordination-method
#6
Yuanzhi Li, Bill Shipley
Can CSR theory, in conjunction with a recently proposed globally calibrated CSR ordination ("StrateFy"), using only three easily measured leaf traits (leaf area, specific leaf area and leaf dry matter content) predict the functional signature of herbaceous vegetation along experimentally manipulated gradients of soil fertility and disturbance? To determine this, we grew 37 herbaceous species in mixture for five years in 24 experimental mesocosms differing in factorial levels of soil resources (stress) and density-independent mortality (disturbance)...
2017: PloS One
https://www.readbyqxmd.com/read/28388279/investigation-of-aid-dicer-and-drosha-expressions-in-patients-with-chronic-lymphocytic-leukemia
#7
Metin Yusuf Gelmez, Ender Coskunpinar, Basak Saracoglu, Gunnur Deniz, Melih Aktan
Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. Cytogenetic lesions such as del13q14, del11q22.3, and del17p13 are identified in 50-60% of patients. Activation-induced cytidine deaminase (AID) plays a central role in somatic hyper mutation (SHM) and class switch recombination (CSR) and functions on Ig genes, but also target non-Ig genes, and over-expression of AID can lead to point mutations or translocations in non-Ig genes such as IgH/Myc translocation. Dicer and Drosha, which have a role in activation process of miRNA, also act in a double-strand DNA break (DSB) repair mechanism...
April 7, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28384250/development-of-closed-loop-supply-chain-network-in-terms-of-corporate-social-responsibility
#8
Ali Pedram, Payam Pedram, Nukman Bin Yusoff, Shahryar Sorooshian
Due to the rise in awareness of environmental issues and the depletion of virgin resources, many firms have attempted to increase the sustainability of their activities. One efficient way to elevate sustainability is the consideration of corporate social responsibility (CSR) by designing a closed loop supply chain (CLSC). This paper has developed a mathematical model to increase corporate social responsibility in terms of job creation. Moreover the model, in addition to increasing total CLSC profit, provides a range of strategic decision solutions for decision makers to select a best action plan for a CLSC...
2017: PloS One
https://www.readbyqxmd.com/read/28381520/melamine-induces-ca-2-sensing-receptor-activation-and-elicits-apoptosis-in-proximal-tubular-cells
#9
Allen J Yiu, Cliff-Lawrence Ibeh, Sanjit K Roy, Bidhan C Bandyopadhyay
Melamine causes renal tubular cell injury through inflammation, fibrosis and apoptosis. While melamine effects the rise in intracellular Ca(2+) concentration ([Ca(2+)]i), reactive oxygen species (ROS) production, and pro-apoptotic pathway activation, the mechanism of upstream Ca(2+) signaling is unknown. Since melamine has some structural similarities with L-amino acids, which endogenously activates Ca(2+)-sensing receptors (CSR), we examined the effect of melamine on CSR-induced Ca(2+) signaling and apoptotic cell death...
April 5, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28379619/blood-pressure-lowering-efficacy-of-renin-inhibitors-for-primary-hypertension
#10
REVIEW
Vijaya M Musini, Kendra Ak Lawrence, Patricia M Fortin, Ken Bassett, James M Wright
BACKGROUND: Hypertension is a chronic condition associated with an increased risk of mortality and morbidity. Renin is the enzyme responsible for converting angiotensinogen to angiotensin I, which is then converted to angiotensin II. Renin inhibitors are a new class of drugs that decrease blood pressure (BP) by preventing the formation of both angiotensin I and angiotensin II. OBJECTIVES: To quantify the dose-related BP lowering efficacy of renin inhibitors compared to placebo in the treatment of primary hypertension...
April 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28371086/immediate-implant-and-rehabilitation-based-on-all-on-4-concept-in-patients-with-generalized-aggressive-periodontitis-a-medium-term-prospective-study
#11
Sha Li, Ping Di, Yu Zhang, Ye Lin
BACKGROUND: Aggressive periodontitis renders a great challenge to the conventional implant due to the risks of infection and ongoing marginal bone loss (MBL). A study about full-arch immediate implant and restoration in patients with advanced generalized aggressive periodontitis (GAP) was not read, even though the All-on-4 concept has been proven to be predictable for edentulous patients. PURPOSE: This prospective study aimed to evaluate the feasibility and medium-term outcomes of immediate implant and rehabilitation based on the All-on-4 concept in patients with advanced GAP via clinical and radiographic analyses...
April 3, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28369716/corporate-social-responsibility-and-conflicts-of-interest-in-the-alcohol-and-gambling-industries-a-post-political-discourse
#12
Ben Baumberg Geiger, Valentina Cuzzocrea
The corporate pursuit of social goals - known as Corporate Social Responsibility or 'CSR' - has been subject to critique on a number of grounds. However, a hitherto underexplored potential consequence of CSR has been suggested in a recent paper by C. Garsten and K. Jacobsson ('Post-Political Regulation: Soft Power and Post-political Visions in Global Governance' (2013), Critical Sociology 39: 421-37). They suggest that CSR is part of an international trend towards 'post-political' governance discourses, where an emphasis on different actors' common goals obscures conflicts of interest, subverting the open political conflict necessary for a well-functioning democracy...
March 28, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28369649/functional-anatomy-of-the-immunoglobulin-heavy-chain-3%C3%AE-super-enhancer-needs-not-only-core-enhancer-elements-but-also-their-unique-dna-context
#13
Sandrine Le Noir, François Boyer, Sandrine Lecardeur, Mylène Brousse, Zeliha Oruc, Jeanne Cook-Moreau, Yves Denizot, Michel Cogné
Cis-regulatory elements feature clustered sites for transcription factors, defining core enhancers and have inter-species homology. The mouse IgH 3΄ regulatory region (3'RR), a major B-cell super-enhancer, consists of four of such core enhancers, scattered throughout more than 25 kb of packaging 'junk DNA', the sequence of which is not conserved but follows a unique palindromic architecture which is conserved in all mammalian species. The 3'RR promotes long-range interactions and potential IgH loops with upstream promoters, controlling class switch recombination (CSR) and somatic hypermutation (SHM)...
March 22, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28365234/chart-stimulated-recall-as-a-learning-tool-for-improving-radiology-residents-reports
#14
Naila Nadeem, Abdul Mueed Zafar, Sonia Haider, Rukhsana W Zuberi, Muhammad Nadeem Ahmad, Vijayanadh Ojili
RATIONALE AND OBJECTIVES: Workplace-based assessments gauge the highest tier of clinical competence. Chart-stimulated recall (CSR) is a workplace-based assessment method that complements chart audit with an interview based on the residents' notes. It allows evaluation of the residents' knowledge and heuristics while providing opportunities for feedback and self-reflection. We evaluated the utility of CSR for improving the radiology residents' reporting skills. MATERIALS AND METHODS: Residents in each year of training were randomly assigned to an intervention group (n = 12) or a control group (n = 13)...
March 29, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28337059/cataract-surgical-rate-in-yemen-2012
#15
Saleh A Al-Akily, Mutahar Y AlShaer, Mahfouth A Bamashmus, Abdulmoghni O AlBarrag, Tawfik K Alkhatib, Hisham A Al-Akhlee
OBJECTIVE: To determine cataract surgical rate (CSR) in 2012 (01 January to 31 December 2012) in 22 Governorates of Yemen in order to identify the needs to reduce cataract related blindness. METHODS: A standardized questionnaire was sent to the 184 eye units in governmental, university, military, private and charity clinics and hospitals in Yemen. RESULTS: The response rate to the questionnaire was 80.7%, and the collected data are summarized...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28334057/esthetic-and-patient-centered-outcomes-of-single-implants-a-retrospective-study
#16
Björn Gjelvold, Bruno Ramos Chrcanovic, Ingrid Collin Bagewitz, Jenö Kisch, Tomas Albrektsson, Ann Wennerberg
PURPOSE: The aims of this clinical study were to retrospectively evaluate implant survival, patient satisfaction, and radiographic, clinical, and esthetic outcomes following single-implant treatment. MATERIALS AND METHODS: Eighty-seven patients, with a total of 126 implants (XiVE S, Dentsply Implants), who received single implant-retained crowns between 2004 and 2011 were retrospectively evaluated. Implant survival, marginal bone levels (MBL), changes in implant/mesial tooth vertical relationship, pink esthetic score (PES), white esthetic score (WES), patient assessment of the esthetics (visual analog scale), and oral health impact profile (OHIP-14) were evaluated...
March 23, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28321166/outcomes-of-gastrointestinal-defect-closure-with-an-over-the-scope-clip-system-in-a-multicenter-experience-an-analysis-of-a-successful-suction-method
#17
Hideki Kobara, Hirohito Mori, Shintaro Fujihara, Noriko Nishiyama, Taiga Chiyo, Takayoshi Yamada, Masao Fujiwara, Keiichi Okano, Yasuyuki Suzuki, Masayuki Murota, Yoshitaka Ikeda, Makoto Oryu, Mohamed AboEllail, Tsutomu Masaki
AIM: To demonstrate the clinical outcomes of a multicenter experience and to suggest guidelines for choosing a suction method. METHODS: This retrospective study at 5 medical centers involved 58 consecutive patients undergoing over-the-scope clips (OTSCs) placement. The overall rates of technical success (TSR), clinical success (CSR), complications, and procedure time were analyzed as major outcomes. Subsequently, 56 patients, excluding two cases that used the Anchor device, were divided into two groups: 14 cases of simple suction (SS-group) and 42 cases using the Twin Grasper (TG-group)...
March 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28320524/seasonally-related-effects-on-natural-organic-matter-characteristics-from-source-to-tap-in-korea
#18
S H So, I H Choi, H C Kim, S K Maeng
In this study, natural organic matter (NOM) characteristics were investigated over three years of monthly monitoring to determine the effect of seasonal variations on NOM levels from source to tap. Liquid chromatography with organic carbon detection (LC-OCD) was used to determine NOM characteristics and the level of reduction of biodegradable dissolved organic carbon (BDOC). The average dissolved organic matter concentration in the source water (Lake Paldang, Korea) was not significantly different between summer and winter...
March 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28314626/cerebral-hemodynamic-effects-of-cheyne-stokes-respiration-in-a-patient-with-stroke
#19
R C Nogueira, R B Panerai, M J Teixeira, T G Robinson, E Bor-Seng-Shu
INTRODUCTION: Cheyne-Stokes respiration (CSR) and central sleep apnea (CSA) are common in patients with heart failure and/or stroke. We aim to describe the cerebrovascular effects of CSR during the acute phase of stroke in a heart failure patient. CASE REPORT: A 74-year-old male with previous dilated cardiomyopathy had sudden onset of right hemiparesis and aphasia. A transcranial Doppler was performed with continuous measurement of blood pressure (BP) (Finometer) and end-tidal CO2 (nasal capnography)...
March 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28306346/risk-factors-for-central-serous-chorioretinopathy-multivariate-approach-in-a-case-control-study
#20
Irini Chatziralli, Stamatina A Kabanarou, Efstratios Parikakis, Alexandros Chatzirallis, Tina Xirou, Panagiotis Mitropoulos
PURPOSE: The purpose of this prospective study was to investigate the potential risk factors associated independently with central serous retinopathy (CSR) in a Greek population, using multivariate approach. MATERIALS AND METHODS: Participants in the study were 183 consecutive patients diagnosed with CSR and 183 controls, matched for age. All participants underwent complete ophthalmological examination and information regarding their sociodemographic, clinical, medical and ophthalmological history were recorded, so as to assess potential risk factors for CSR...
March 17, 2017: Current Eye Research
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