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https://www.readbyqxmd.com/read/28618169/ecg-derived-cheyne-stokes-respiration-and-periodic-breathing-in-healthy-and-hospitalized-populations
#1
Adelita Tinoco, Barbara J Drew, Xiao Hu, David Mortara, Bruce A Cooper, Michele M Pelter
BACKGROUND: Cheyne-Stokes respiration (CSR) has been investigated primarily in outpatients with heart failure. In this study we compare CSR and periodic breathing (PB) between healthy and cardiac groups. METHODS: We compared CSR and PB, measured during 24 hr of continuous 12-lead electrocardiographic (ECG) Holter recording, in a group of 90 hospitalized patients presenting to the emergency department with symptoms suggestive of acute coronary syndrome (ACS) to a group of 100 healthy ambulatory participants...
June 15, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28600234/rescsrf-algorithm-to-automatically-extract-cheyne-stokes-respiration-features-from-respiratory-signals
#2
Faizan Javed, Henrik Fox
OBJECTIVE: Cheyne-Stokes respiration (CSR) related features are significantly associated with cardiac dysfunction. Scoring of these features is labor-intensive and time-consuming. To automate the scoring process, an algorithm (ResCSRF) has been developed to extract these features from nocturnal measurement of respiratory signals. METHODS: ResCSRF takes 4 signals (nasal flow, thorax, abdomen and finger oxygen saturation) as input. It first detects CSR cycles and then calculates the respiratory features [cyclelength (CL), lung-to-periphery circulation time (LPCT) and time to peak flow (TTPF)]...
June 5, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28599825/left-ventricular-rotational-and-twist-mechanics-in%C3%A2-the-human-fetal-heart
#3
Ling Li, Mary Craft, Hao H Hsu, Ming Zhang, Berthold Klas, David A Danford, Shelby Kutty
BACKGROUND: The authors investigated left ventricular (LV) rotational indices, twist, and torsion in a large cohort of fetuses using two-dimensional speckle-tracking echocardiography. METHODS: Pregnant women (N = 102) were prospectively recruited for fetal two-dimensional speckle-tracking echocardiography. Because of variable fetal position, ventricular orientation was established using the location of the liver and LV position in relation to the right ventricle...
June 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28574927/altered-functional-connectivity-of-the-periaqueductal-gray-in-chronic-neck-and-shoulder-pain
#4
Cheng-Xin Yu, Bo Li, Ya-Ka Xu, Ting-Ting Ji, Liang Li, Chang-Jiang Zhao, Long Chen, Zhi-Zheng Zhuo
Chronic neck and shoulder pain with cervical spondylotic radiculopathy (CNSP-CSR) is one of the most common clinical chronic pain diseases. This study aimed to investigate the abnormal patterns in functional connectivity (FC) pertaining to the periaqueductal gray matter (PAG) in patients with CNSP-CSR. A seed-based FC analysis was carried out for the right ventrolateral PAG and a correlation analysis was carried out with pain intensity, duration, and the extracted mean z scores. The PAG FC was significantly positively associated with the right orbital inferior frontal gyrus, supramarginal gyrus/postcentral gyrus, putamen, and the left anterior cingulate cortex, and significant negative FC was observed in the right lingual gyrus/occipital cortex in patients with CNSP-CSR...
June 1, 2017: Neuroreport
https://www.readbyqxmd.com/read/28574479/r-loops-in-the-regulation-of-antibody-gene-diversification
#5
REVIEW
Rushad Pavri
For nearly three decades, R loops have been closely linked with class switch recombination (CSR), the process that generates antibody isotypes and that occurs via a complex cascade initiated by transcription-coupled mutagenesis in switch recombination sequences. R loops form during transcription of switch recombination sequences in vitro and in vivo, and there is solid evidence that R loops are required for efficient class switching. The classical model of R loops posits that they boost mutation rates by generating stable and long tracts of single-stranded DNA that serve as the substrate for activation induced deaminase (AID), the enzyme that initiates the CSR reaction cascade by co-transcriptionally mutating ssDNA in switch recombination sequences...
June 2, 2017: Genes
https://www.readbyqxmd.com/read/28550350/recent-advances-in-the-study-of-immunodeficiency-and-dna-damage-response
#6
REVIEW
Tomohiro Morio
DNA breaks can be induced by exogenous stimuli or by endogenous stress, but are also generated during recombination of V, D, and J genes (V(D)J recombination), immunoglobulin class switch recombination (CSR). Among various DNA breaks generated, DNA double strand break (DSB) is the most deleterious one. DNA damage response (DDR) is initiated when DSBs are detected, leading to DNA break repair by non-homologous end joining (NHEJ). The process is critically important for the generation of diversity for foreign antigens; and failure to exert DNA repair leads to immunodeficiency such as severe combined immunodeficiency and hyper-IgM syndrome...
May 26, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28539349/sleep-loss-promotes-astrocytic-phagocytosis-and-microglial-activation-in-mouse-cerebral-cortex
#7
Michele Bellesi, Luisa de Vivo, Mattia Chini, Francesca Gilli, Giulio Tononi, Chiara Cirelli
We previously found that Mertk and its ligand Gas6, astrocytic genes involved in phagocytosis, are upregulated after acute sleep deprivation. These results suggested that astrocytes may engage in phagocytic activity during extended wake, but direct evidence was lacking. Studies in humans and rodents also found that sleep loss increases peripheral markers of inflammation, but whether these changes are associated with neuroinflammation and/or activation of microglia, the brain's resident innate immune cells, was unknown...
May 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28535205/a-transcriptional-serenaid-the-role-of-noncoding-rnas-in-class-switch-recombination
#8
William T Yewdell, Jayanta Chaudhuri
During an immune response, activated B cells may undergo class switch recombination (CSR), a molecular rearrangement that allows B cells to switch from expressing IgM and IgD to a secondary antibody heavy chain isotype such as IgG, IgA, or IgE. Secondary antibody isotypes provide the adaptive immune system with distinct effector functions to optimally combat various pathogens. CSR occurs between repetitive DNA elements within the immunoglobulin heavy chain (Igh) locus, termed switch (S) regions, and requires the DNA modifying enzyme activation-induced cytidine deaminase (AID)...
May 23, 2017: International Immunology
https://www.readbyqxmd.com/read/28534802/organ-location-determination-and-contour-sparse-representation-for-multi-organ-segmentation
#9
Siqi Li, Huiyan Jiang, Yu-Dong Yao, Benqiang Yang
Organ segmentation on computed tomography (CT) images is of great importance in medical diagnoses and treatment. This paper proposes organ location determination and contour sparse representation methods (OLD-CSR) for multiorgan segmentation (liver, kidney, and spleen) on abdomen CT images using an extreme learning machine (ELM) classifier. First, a location determination method is designed to obtain location information of each organ, which is used for coarse segmentation. Second, for coarse-to-fine segmentation, a contour gradient and rate change based feature point extraction method is proposed...
May 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28534715/knowledge-attitudes-and-behaviors-related-to-child-safety-restraint-in-citizens-of-shenzhen-municipality-china-and-the-associations-between-these-factors
#10
Shengyuan Liu, Haibin Zhou, Jianping Ma, Changyi Wang, Zhongwei Chen, Sihan Chen, Yingzhou Yang, Xiaoli Liu, Ji Peng, Leilei Duan, Xiao Deng
Objective-A child safety restraint (CSR) is an effective measure to reduce the risk of child injury from traffic collisions. This study aims to explore knowledge, attitudes and behaviors regarding CSR in a Chinese population. Methods-A cross-sectional survey regarding CSR use was conducted from April to May 2014 in Shenzhen Municipality. Respondents were parents who had at least one child 0 to 6 years of age and simultaneously owned a car. These parents provided a self-report of demographic characteristics as well as information about their knowledge, attitudes and behaviors toward CSR use...
May 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28533409/inducible-ctcf-insulator-delays-the-igh-3-regulatory-region-mediated-activation-of-germline-promoters-and-alters-class-switching
#11
Fatima-Zohra Braikia, Chloé Oudinet, Dania Haddad, Zeliha Oruc, Domenico Orlando, Audrey Dauba, Marc Le Bert, Ahmed Amine Khamlichi
Class switch recombination (CSR) plays an important role in adaptive immune response by enabling mature B cells to switch from IgM expression to the expression of downstream isotypes. CSR is preceded by inducible germline (GL) transcription of the constant genes and is controlled by the 3' regulatory region (3'RR) in a stimulus-dependent manner. Why the 3'RR-mediated up-regulation of GL transcription is delayed to the mature B-cell stage is presently unknown. Here we show that mice devoid of an inducible CTCF binding element, located in the α constant gene, display a marked isotype-specific increase of GL transcription in developing and resting splenic B cells and altered CSR in activated B cells...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28515723/different-somatic-hypermutation-levels-among-antibody-subclasses-disclosed-by-a-new-next-generation-sequencing-based-antibody-repertoire-analysis
#12
Kazutaka Kitaura, Hiroshi Yamashita, Hitomi Ayabe, Tadasu Shini, Takaji Matsutani, Ryuji Suzuki
A diverse antibody repertoire is primarily generated by the rearrangement of V, D, and J genes and subsequent somatic hypermutation (SHM). Class-switch recombination (CSR) produces various isotypes and subclasses with different functional properties. Although antibody isotypes and subclasses are considered to be produced by both direct and sequential CSR, it is still not fully understood how SHMs accumulate during the process in which antibody subclasses are generated. Here, we developed a new next-generation sequencing (NGS)-based antibody repertoire analysis capable of identifying all antibody isotype and subclass genes and used it to examine the peripheral blood mononuclear cells of 12 healthy individuals...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28509355/lon-protease-modulates-virulence-traits-in-erwinia-amylovora-by-directly-monitoring-major-regulators-and-indirectly-through-the-rcs-and-gac-csr-regulatory-systems
#13
Jae Hoon Lee, Veronica Ancona, Youfu Zhao
Lon, an ATP-dependent protease in bacteria, influences diverse cellular processes by degrading damaged, misfolded and short-lived regulatory proteins. In this study, we characterized the effects of lon mutation and determined the molecular mechanisms underlying Lon-mediated virulence regulation in Erwinia amylovora, an enterobacterial pathogen of apple. E. amylovora depends on the type III secretion system (T3SS) and the exopolysaccharide (EPS) amylovoran to cause disease. Our results showed that mutation of the lon gene led to overproduction of amylovoran, increased T3SS gene expression and non-motile phenotype...
May 16, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28508466/comparison-of-the-time-taken-for-localised-breast-surgery-pre-and-post-introduction-of-intra-operative-digital-specimen-mammography
#14
Vinicius Carraro do Nascimento, Anita G Bourke
INTRODUCTION: More than half of the patients with an impalpable malignant breast lesion have a mammographically detected and imaged-guided localisation, which can be technically challenging for the breast surgeon. Specimen imaging is used to confirm successful excision of the localised index lesion and has improved the operating list efficiency resulting in a higher number of excisions per surgical list. The aim of this study was to evaluate whether introducing IDSM (intra-operative digital specimen mammography) saved operation time for localised breast surgery...
May 16, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28497846/survival-after-second-and-subsequent-recurrences-in-osteosarcoma-a-retrospective-multicenter-analysis
#15
Elisa Tirtei, Sebastian D Asaftei, Rosaria Manicone, Marilena Cesari, Anna Paioli, Michele Rocca, Stefano Ferrari, Franca Fagioli
PURPOSE: Osteosarcoma (OS) is the most common primary bone tumor. Despite complete surgical removal and intensive chemotherapeutic treatment, 30%-35% of patients with OS have local or systemic recurrence. Some patients survive multiple recurrences, but overall survival after OS recurrence is poor. This analysis aims to describe and identify factors influencing post-relapse survival (PRS) after a second OS relapse. METHODS: This is a retrospective analysis of 60 patients with a second relapse of OS of the extremities in 2 Italian centers between 2003 and 2013...
May 10, 2017: Tumori
https://www.readbyqxmd.com/read/28493692/uptake-kinetics-and-subcellular-compartmentalization-explain-lethal-but-not-sublethal-effects-of-cadmium-in-two-closely-related-amphipod-species
#16
Lena Jakob, Daria S Bedulina, Denis V Axenov-Gribanov, Michael Ginzburg, Zhanna M Shatilina, Yulia A Lubyaga, Ekaterina V Madyarova, Anton N Gurkov, Maxim A Timofeyev, Hans-O Pörtner, Franz J Sartoris, Rolf Altenburger, Till Luckenbach
Eulimnogammarus cyaneus and Eulimnogammarus verrucosus, closely related amphipod species endemic to Lake Baikal, differ with respect to body size (10- to 50-fold lower fresh weights of E. cyaneus) and cellular stress response (CSR) capacity, potentially causing species-related differences in uptake, internal sequestration, and toxic sensitivity to waterborne cadmium (Cd). We found that, compared to E. verrucosus, Cd uptake rates, related to a given exposure concentration, were higher, and lethal concentrations (50%; LC50) were 2...
June 1, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28487533/spatial-and-temporal-patterns-of-commercial-citrus-trees-affected-by-phyllosticta-citricarpa-in-florida
#17
Katherine E Hendricks, Mary Christman, Pamela D Roberts
Citrus black spot (CBS) caused by Phyllosticta citricarpa, is the most recent introduction of an exotic citrus pathogen into Florida and has been a challenge to control to date. Understanding the dispersal pattern of the disease within affected groves is vital in developing effective control strategies to limit the spread of the disease. The spatial pattern of CBS-affected trees was studied in two commercial 'Valencia' orange groves over three consecutive citrus seasons. Cluster analyses based on nearest-neighbor distance (F, G and J-functions) and pairwise distances between points (Ripley's K function, Besag's L function and the pair correlation function, g) were used to test the hypothesis of complete spatial randomness (CSR) of CBS infected trees within the groves...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28482797/association-of-cumulative-social-risk-with-mortality-and-adverse-cardiovascular-disease-outcomes
#18
Sebhat Erqou, Justin B Echouffo-Tcheugui, Kevin E Kip, Aryan Aiyer, Steven E Reis
BACKGROUND: Quantifying the cumulative effect of social risk factors on cardiovascular disease (CVD) risk can help to better understand the sources of disparities in health outcomes. METHOD AND RESULTS: Data from the Heart Strategies Concentrating on Risk Evaluation (HeartSCORE) study were used to create an index of cumulative social risk (CSR) and quantify its association with incident CVD and all-cause mortality. CSR was defined by assigning a score of 1 for the presence of each of 4 social factors: i) racial minority status (Black race), ii) single living status, iii) low income, and iv) low educational level...
May 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28472438/the-impact-of-chronic-sleep-restriction-on-neuronal-number-and-volumetric-correlates-of-the-dorsal-respiratory-nuclei-in-a-rat-model
#19
Ali-Mohammad Kamali, Fatemeh Karimi, Saied Karbalay-Doust, Mohammad Nami, Ali Noorafshan
Study Objectives: Sleep restriction can result in a range of neurophysiological consequences in the brain including some brain stem nuclei. This study aimed to evaluate the effects of chronic sleep restriction (CSR) on quantitative aspects of brain stem respiratory centers using stereological methods. Methods: Male rats were randomly assigned into experimental group (CSR through a modified multiple platform apparatus), corresponding apparatus-control group (grid-floor control) and cage controls...
May 2, 2017: Sleep
https://www.readbyqxmd.com/read/28470132/value-based-hr-practices-i-deals-and-clinical-error-control-with-csr-as-a-moderator
#20
Tuan Luu, Chris Rowley, Sununta Siengthai, Vo Thanh Thao
Purpose Notwithstanding the rising magnitude of system factors in patient safety improvement, "human factors" such as idiosyncratic deals (i-deals) which also contribute to the adjustment of system deficiencies should not be neglected. The purpose of this paper is to investigate the role of value-based HR practices in catalyzing i-deals, which then influence clinical error control. The research further examines the moderating role of corporate social responsibility (CSR) on the effect of value-based HR practices on i-deals...
May 8, 2017: International Journal of Health Care Quality Assurance
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