keyword
https://read.qxmd.com/read/38493008/effects-of-the-covid-19-pandemic-on-gestational-diabetes-in-castilla-la-mancha-spain
#21
JOURNAL ARTICLE
Dulce M ª Calderón Vicente, Amparo Marco Martínez, Inés Gómez García, Rosa Quílez Toboso, Iván Quiroga López, Manolo Delgado Rey, Javier Gargallo Vaamonde, María Olmos Alemán, Raquel Miralles Moragrega, César Gonzalvo Díaz, Javier González López
SUBJECT-MATTER: To assess the effect of the 2019 coronavirus (COVID-19) pandemic on gestational diabetes (GDM). MATERIAL AND METHODS: In this retrospective, multicentre, non-interventional study carried out in Castilla-La Mancha, Spain, we compared 663 women with GDM exposed to the pandemic (pandemic group), with 622 women with GDM seen one year earlier (pre-pandemic group). The primary endpoint was a Large for Gestational Age (LGA) newborn as an indicator of poor GDM control...
March 15, 2024: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/38492741/-neurodevelopment-and-neuroprotection-in-young-children
#22
JOURNAL ARTICLE
Stéphane Marret, Alexandra Chadie, Jean-Baptiste Muller, Clément Chollat
In France, the most pessimistic estimates put the prevalence of neurodevelopmental disorders (NDD) at 15% of births. The two largest populations of newborns at highest risk of NDD are premature babies and babies born into siblings with one or more infants who already have an autism spectrum disorder or another NDD. The high prevalence of these disorders justifies a health promotion policy, centred on the child and his or her family. Prevention is based on the early identification of high-risk factors, by informing families and training pregnancy and early childhood professionals, and implementing perinatal prevention protocols for high-risk newborns (antenatal corticosteroid therapy and magnesium sulfate for women at risk of preterm delivery before 32 weeks, developmental care, therapeutic hypothermia for full-term infants with early neonatal encephalopathy presumed to be anoxic)...
March 14, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38492280/the-most-common-congenital-malformations-in-dogs-literature-review-and-practical-guide
#23
REVIEW
Marina Vilela Estevam, Gilson Helio Toniollo, Maricy Apparicio
Congenital malformations can affect almost 7% of canine newborns. The increase of commercial dog breeding and inbreeding used to maintain the striking characteristics of each breed, the appearance of malformations has become increasingly common, especially in brachycephalic dogs. The causes are diverse, and include genetic, nutritional, iatrogenic, and infectious factors, often making it difficult to establish a cause-consequence relationship. The high mortality associated with malformations comes not only from the fact that some are incompatible with life, but also because even if many undergo surgical treatment or correction, they require specific management, monitoring, and clinical treatment for an indefinite period of time...
March 13, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38492030/clinical-course-and-peculiarities-of-parechovirus-and-enterovirus-central-nervous-system-infections-in-newborns-a-single-center-experience
#24
JOURNAL ARTICLE
Giacomo Brisca, Tommaso Bellini, Mattia Pasquinucci, Marcello Mariani, Marta Romanengo, Isabella Buffoni, Domenico Tortora, Alessandro Parodi, Elena Fueri, Alessio Mesini, Jessica Tibaldi, Emanuela Piccotti, Luca Antonio Ramenghi, Andrea Moscatelli
Parechovirus (HpEV) and Enterovirus (EV) infections in children mostly have a mild course but are particularly fearsome in newborns in whom they may cause aseptic meningitis, encephalitis, and myocarditis. Our study aimed to describe the clinical presentations and peculiarities of CNS infection by HpEV and EV in neonates. This is a single-center retrospective study at Istituto Gaslini, Genoa, Italy. Infants aged ≤ 30 days with a CSF RTq-PCR positive for EV or HpEV from January 1, 2022, to December 1, 2023, were enrolled...
March 16, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38491917/ethical-considerations-in-the-use-of-rhd-positive-blood-products-in-trauma
#25
JOURNAL ARTICLE
Jay R Malone
BACKGROUND: Prehospital and early in-hospital use of low titer group O whole blood (LTOWB) for life-threatening bleeding has been independently associated with improved survival compared to component therapy. However, when RhD-positive blood products are administered to RhD-negative females of childbearing potential (FCP), there is a small future risk of hemolytic disease of the fetus and newborn (HDFN). This raises important ethical questions that must be explored in order to justify the use of RhD-positive blood products, including LTOWB, both in clinical practice and research...
March 16, 2024: Transfusion
https://read.qxmd.com/read/38491449/the-footprint-of-sars-cov-2-infection-in-neonatal-late-sepsis
#26
JOURNAL ARTICLE
Zahra Jamali, Najmeh Mohammadpour, Reza Sinaei, Maedeh Jafari, Fatemeh Sabzevari, Mohammad Hasannejad
BACKGROUND: Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging. METHOD: In this cross-sectional study, which has been done from September 2020 to December 2022, 145 hospitalized neonates suspected to late-onset sepsis alongside routine sepsis workup, were also evaluated for severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, by nasopharyngeal real-time polymerase chain reaction (RT-PCR) or serological tests...
March 16, 2024: BMC Pediatrics
https://read.qxmd.com/read/38490905/an-ongoing-problem-rhesus-hemolytic-disease-of-the-newborn-a-decade-of-experience-in-a-single-centre
#27
JOURNAL ARTICLE
Cansu Yilmaz Yegit, Beril Yasa, Elmas Zeynep Ince, Tugba Sarac Sivrikoz, Asuman Coban
BACKGROUND: The objectives were to evaluate the descriptive features of newborns with a diagnosis of Rhesus (Rh) hemolytic disease, to determine the morbidity and mortality rates, to evaluate the treatment methods and the factors affecting treatment requirements and clinical outcomes during a ten-year period at a tertiary center. METHODS: Newborn infants who had a positive direct Coombs test and/or had a history of intrauterine transfusion (IUT) due to Rh hemolytic disease were included...
March 7, 2024: Pediatrics and Neonatology
https://read.qxmd.com/read/38490698/neonatal-arterial-thrombosis-an-arcane-covid-sequelae
#28
JOURNAL ARTICLE
Aishwarya Vijay, Swathi Shenoy, Seema Pavaman Sindgikar
We describe a case of a term neonate with a swollen right arm and weakened pulses, diagnosed with arterial thromboembolism in the right axillary and brachial arteries. Treatment involved heparin, followed by enoxaparin, resulting in significant improvement. Maternal SARS-CoV-2 infection during pregnancy was considered as a potential factor, supported by the newborn's reactive COVID antibodies. The authors hypothesise a potential correlation between neonatal thrombosis and maternal SARS-CoV-2 infection during pregnancy...
March 15, 2024: BMJ Case Reports
https://read.qxmd.com/read/38490554/responses-to-incremental-nutrient-supply-on-energy-and-protein-metabolism-in-pre-weaning-dairy-calves
#29
JOURNAL ARTICLE
L Amado, L N Leal, H Berends, P van Keulen, J Martín-Tereso, W J J Gerrits
Recently reviewed development objectives and feeding practices in young dairy calves require an adaptation of nutrient recommendations set for milk replacer (MR) composition. Nutrient requirements of calves younger than 21 d of age, and those of calves fed with high levels of milk replacer are insufficiently quantified. The efficiency at which macronutrients are utilized, particularly protein, substantially diminishes with age, and there is little data for the first weeks of life. In addition, in older (pre-)ruminants, protein and energy can be simultaneously limiting for protein gain...
March 13, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38490341/comprehensive-metabolomics-analysis-reveals-novel-biomarkers-and-pathways-in-falsely-suspected-glutaric-aciduria-type-1-newborns
#30
JOURNAL ARTICLE
Essa M Sabi, Maha AlMogren, Rajaa Sebaa, Khalid M Sumaily, Reem AlMalki, Ahmad Mujammami, Anas Abdel Rahman
BACKGROUND: Glutaric aciduria type-1 (GA-1) is a rare metabolic disorder due to glutaryl coenzyme A dehydrogenase deficiency, causing elevated levels of glutaryl-CoA and its derivatives. GA-1 exhibits symptoms like macrocephaly, developmental delays, and movement disorders. Timely diagnosis through genetic testing and newborn screening is crucial. However, in some cases, transiently elevated level of glutarylcarnitine (C5DC) challenges accurate diagnosis, highlighting the need for alternative diagnostic methods, like mass spectrometry-based untargeted metabolomics, to identify additional biomarkers for distinguishing falsely suspected GA-1 from healthy newborns...
March 13, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38490241/evaluation-of-cerebral-autoregulation-of-oxygen-by-nirs-method-during-postnatal-transition-period-in-term-and-late-preterm-newborns-without-resuscitation-requirement
#31
JOURNAL ARTICLE
Omer Ertekin, Mehmet Buyuktiryaki, Sehribanu Isik, Nilufer Okur, Serife Suna Oguz
BACKGROUND: Pulse oximetry is commonly used to monitor arterial oxygen saturation and heart rate during the transition period and reference intervals have been determined. However, the effect of the change in arterial oxygen saturation on tissue oxygenation does not seem to be the same. So, a non-invasive method for monitoring cerebral or regional tissue oxygenation will be potentially useful for vulnerable infants. This study aims to evaluate the effectiveness of cerebral autoregulation in the first 10 min after delivery in term and late preterm newborns without resuscitation requirement...
February 7, 2024: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38490048/immature-porcine-cortical-bone-mechanical-properties-and-composition-change-with-maturation-and-displacement-rate
#32
JOURNAL ARTICLE
Emily Szabo, Jay Bensusan, Ozan Akkus, Clare Rimnac
Computational models of mature bone have been used to predict fracture; however, analogous study of immature diaphyseal fracture has not been conducted due to sparse experimental mechanical data. A model of immature bone fracture may be used to aid in the differentiation of accidental and non-accidental trauma fractures in young, newly ambulatory children (0-3 years). The objective of this study was to characterize the evolution of tissue-level mechanical behavior, composition, and microstructure of maturing cortical porcine bone with uniaxial tension, Raman spectroscopy, and light microscopy as a function of maturation...
March 6, 2024: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/38490047/dose-dependent-increase-in-risk-of-bleeding-and-bleeding-complications-in-relation-to-ssri-use-at-delivery
#33
JOURNAL ARTICLE
Malin Öndemark, Lennart Nordström, Pelle G Lindqvist
INTRODUCTION: Depression during pregnancy is a severe state that increases the risk of suicide, as well as adverse newborn outcomes. Selective serotonin re-uptake inhibitors (SSRIs) are effective for the treatment of depression, but increase the risk of bleeding complications at delivery. Knowledge on the dose dependency of this association is lacking. METHODS: A hospital-based cohort study of all women who gave birth at Karolinska University Hospital in Stockholm over the 5-year period from 2007 to 2011, with or without SSRI use, was undertaken...
March 2, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38489727/vaginal-delivery-of-triplets-after-emergency-transvaginal-cerclage-a-case-report-and-literature-review
#34
JOURNAL ARTICLE
Tong Zou, Yi-Cheng Wu, Qiang Yao
RATIONALE: To report a peculiar case of vaginal delivery of a triplet after emergency transvaginal cerclage and to find a way to optimize some extreme situations encountered in clinical practice after evaluating feasibility. PATIENT CONCERNS: A 33-year-old gravida 6, para 0050 woman at 21 + 6 weeks of gestation was referred to the obstetric department for opening of the cervical canal. An emergency McDonald cerclage was performed at 22 weeks of gestation after a comprehensive assessment, and the pregnancy ended with vaginal delivery at 24 + 6 weeks of gestation...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489714/lipid-emulsion-treatment-for-local-anesthetic-systemic-toxicity-in-pediatric-patients-a-systematic-review
#35
JOURNAL ARTICLE
Soo Hee Lee, Sunmin Kim, Ju-Tae Sohn
BACKGROUND: Local anesthetic systemic toxicity (LAST) is rare, but fatal; the current widely used treatment is lipid emulsion (LE). The goal of this study was to analyze and review case reports on LE treatment for LAST in pediatric patients. METHODS: We performed a systematic review using case reports on LE treatment for LAST in pediatric patients, searching PubMed and Scopus databases to March 2023 using the following keywords: ("local anesthetic toxicity" OR "local anesthetic systemic toxicity" OR LAST") AND ("newborn" OR "infant" OR "child" OR "children" OR "adolescent" OR "pediatric") AND ("lipid emulsion" OR "Intralipid")...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489687/spontaneous-uterine-rupture-with-amniotic-sac-protrusion-during-the-third-trimester-of-a-unicornuate-uterus-pregnancy-a-rate-case-report
#36
JOURNAL ARTICLE
Yin Yin, Linlin Wang, Zhihong Shi, Yuxin Ma, Juan Yina
RATIONALE: Uterine rupture is an obstetrical emergency associated with severe maternal and fetal mortality. It is rare in the unscarred uterus of a primipara. PATIENT CONCERNS: A 25-year-old woman in her 38th week of gestation presented with slight abdominal pain of sudden onset 10 hours before. An emergency cesarean section was done. After surgery, the patient and the infant survived. DIAGNOSES: With slight abdominal pain of clinical signs, ultrasound examination showed that the amniotic sac was found in the peritoneal cavity with a rupture of the uterine fundus...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489291/perceived-progress-toward-scale-of-14-maternal-newborn-child-health-and-nutrition-mnchn-assets-at-subnational-level-in-burkina-faso-ethiopia-india-kenya-and-nigeria
#37
JOURNAL ARTICLE
Patricia S Coffey, Sadaf Khan, Elan Ebeling, Cyril Engmann
Inequitable coverage of evidence-based MNCHN interventions is particularly pronounced in low and middle income countries where access and delivery of these interventions can vary dramatically at the subnational level. We conducted health system assessments in nine subnational geographies in five countries (Burkina Faso, Ethiopia, India, Kenya and Nigeria) to explore progress toward scale of 14 evidence-based MNCHN interventions (iron-folic acid, oxytocin, magnesium sulfate, misoprostol; 7.1% chlorhexidine for umbilical cord care, neonatal resuscitation, kangaroo mother care, community regimen for the treatment of possible severe bacterial infection; amoxicillin dispersible tablets, multiple micronutrient supplements, balanced energy protein supplementation, early and exclusive breastfeeding, feeding of small and sick newborns, and management of severe and moderate acute malnutrition in children less than five years old)...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38489107/sex-differences-in-autistic-youth-born-extremely-preterm
#38
JOURNAL ARTICLE
Tyler C McFayden, Clare Harrop, Kyle Roell, Robert M Joseph, Rebecca C Fry, T Michael O'Shea
PURPOSE: To evaluate sex differences in autistic traits in youth born extremely preterm (EP; 23-27 weeks) who were later diagnosed with autism spectrum disorder (ASD) at 10-years. METHOD: A longitudinal cohort design from the Extremely Low Gestational Age Newborn Study (ELGAN) followed N = 857 EP infants from birth through 10-years. EP infants later diagnosed with ASD (N = 61, 20 females) participated in the study. Group differences were evaluated via inferential and Bayesian statistics (values > 1 suggest evidence for alternate hypothesis) on ASD screeners (M-CHAT at 2-years, SCQ and SRS-2 at 10-years), and gold-standard diagnostic measures (ADOS-2, ADI-R) at 10-years...
March 15, 2024: Journal of Autism and Developmental Disorders
https://read.qxmd.com/read/38488981/influenza-a-virus-pb1-f2-induces-affective-disorder-by-interfering-synaptic-plasticity-in-hippocampal-dentate-gyrus
#39
JOURNAL ARTICLE
Saiying Wang, Haijun Zhang, Rui Liu, Peijun Han, Qi Yang, Caiyan Cheng, Yue Chen, Zheng Rong, Chang Su, Fei Li, Gaofei Wei, Minggao Zhao, Le Yang
Influenza A virus (IAV) infection, which leads to millions of new cases annually, affects many tissues and organs of the human body, including the central nervous system (CNS). The incidence of affective disorders has increased after the flu pandemic; however, the potential mechanism has not been elucidated. PB1-F2, a key virulence molecule of various influenza virus strains, has been shown to inhibit cell proliferation and induce host inflammation; however, its role in the CNS has not been studied. In this study, we constructed and injected PB1-F2 into the hippocampal dentate gyrus (DG), a region closely associated with newborn neurons and neural development, to evaluate its influence on negative affective behaviors and learning performance in mice...
March 15, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38488905/which-is-the-optimal-choice-for-neonates-formula-or-breast-milk
#40
JOURNAL ARTICLE
Yueqi Hu, Xing Wu, Li Zhou, Jikai Liu
The incidence of prematurity has been increasing since the twenty-first century. Premature neonates are extremely vulnerable and require a rich supply of nutrients, including carbohydrates, proteins, docosahexaenoic acid (DHA), arachidonic acid (ARA) and others. Typical breast milk serves as the primary source for infants under six months old to provide these nutrients. However, depending on the individual needs of preterm infants, a more diverse and intricate range of nutrients may be necessary. This paper provides a comprehensive review of the current research progress on the physical and chemical properties, biological activity, function, and structure of breast milk, as well as explores the relationship between the main components of milk globular membrane and infant growth...
March 15, 2024: Natural Products and Bioprospecting
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