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https://www.readbyqxmd.com/read/28095402/a-general-shear-dependent-model-for-thrombus-formation
#1
Alireza Yazdani, He Li, Jay D Humphrey, George Em Karniadakis
Modeling the transport, activation, and adhesion of platelets is crucial in predicting thrombus formation and growth following a thrombotic event in normal or pathological conditions. We propose a shear-dependent platelet adhesive model based on the Morse potential that is calibrated by existing in vivo and in vitro experimental data and can be used over a wide range of flow shear rates ([Formula: see text]). We introduce an Eulerian-Lagrangian model where hemodynamics is solved on a fixed Eulerian grid, while platelets are tracked using a Lagrangian framework...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28092861/a-deafening-flash-visual-interference-of-auditory-signal-detection
#2
Christopher Fassnidge, Claudia Cecconi Marcotti, Elliot Freeman
In some people, visual stimulation evokes auditory sensations. How prevalent and how perceptually real is this? 22% of our neurotypical adult participants responded 'Yes' when asked whether they heard faint sounds accompanying flash stimuli, and showed significantly better ability to discriminate visual 'Morse-code' sequences. This benefit might arise from an ability to recode visual signals as sounds, thus taking advantage of superior temporal acuity of audition. In support of this, those who showed better visual relative to auditory sequence discrimination also had poorer auditory detection in the presence of uninformative visual flashes, though this was independent of awareness of visually-evoked sounds...
January 13, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28080093/psychometric-properties-of-the-short-inventory-of-problems-sip-with-adjudicated-dui-intervention-participants
#3
David T Morse, Angela A Robertson
We used responses of two large samples of court-ordered participants from a statewide alcohol/driving safety program to investigate factor structure, score reliability, and criterion-related validity of the Short Inventory of Problems (SIP). Exploratory and confirmatory factor analyses, using both item-level and subscore-level data, support a one-factor structure for the SIP. Internal consistency score reliability estimates were consistent across samples and high enough to warrant use for making decisions about individuals...
January 12, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28078111/percutaneous-biliary-drainage-catheter-insertion-in-patients-with-extensive-hepatic-metastatic-tumor-burden
#4
Eun L Langman, Paul V Suhocki, Herbert I Hurwitz, Michael A Morse, Rebecca A Burbridge, Tony P Smith, Charles Y Kim
BACKGROUND: Patients with metastatic disease of the liver can have hyperbilirubinemia due to a number of reasons, including biliary obstruction. The purpose of this study was to analyze patient outcomes after percutaneous biliary drainage (PBD) catheter insertion in patients with extensive hepatic metastatic tumor burden. METHODS: Out of 746 PBD insertions, 44 patients (24 males, 20 females, mean age 57.4 years, range, 34-80 years) had metastatic malignancy with a hepatic tumor burden of greater than 20% parenchymal volume based on pre-procedure computed tomography (CT) or magnetic resonance imaging (MRI)...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28074841/the-mito-damp-cardiolipin-blocks-il-10-production-causing-persistent-inflammation-during-bacterial-pneumonia
#5
Krishnendu Chakraborty, Mahesh Raundhal, Bill B Chen, Christina Morse, Yulia Y Tyurina, Anupriya Khare, Timothy B Oriss, Rachael Huff, Janet S Lee, Claudette M St Croix, Simon Watkins, Rama K Mallampalli, Valerian E Kagan, Anuradha Ray, Prabir Ray
Bacterial pneumonia is a significant healthcare burden worldwide. Failure to resolve inflammation after infection precipitates lung injury and an increase in morbidity and mortality. Gram-negative bacteria are common in pneumonia and increased levels of the mito-damage-associated molecular pattern (DAMP) cardiolipin can be detected in the lungs. Here we show that mice infected with Klebsiella pneumoniae develop lung injury with accumulation of cardiolipin. Cardiolipin inhibits resolution of inflammation by suppressing production of anti-inflammatory IL-10 by lung CD11b(+)Ly6G(int)Ly6C(lo)F4/80(+) cells...
January 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28073541/the-main-nitrate-transporter-of-the-dinoflagellate-lingulodinium-polyedrum-is-constitutively-expressed-and-not-responsible-for-daily-variations-in-nitrate-uptake-rates
#6
Steve Dagenais Bellefeuille, David Morse
Dinoflagellates are unicellular eukaryotes capable of forming spectacular harmful algal blooms (HABs). Eutrophication of coastal waters by fertilizer runoff, nitrate in particular, has contributed to recent increases in the frequency, magnitude and geographic extent of HABs. Although physiological nitrate uptake and assimilation in dinoflagellates have often been measured in the field and in the laboratory, no molecular components involved in nitrate transport have yet been reported. This study reports the first identification and characterization of dinoflagellate nitrate transporters, found in the transcriptome of the bloom-forming Lingulodinium polyedrum...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28072999/-features-and-advances-of-morse-taper-connection-in-oral-implant
#7
C L Tang, S K Zhao, C Huang
Dental implants have been widely accepted as a predictable and reliable tool for dental reconstruction with the development of the economy. The design of implant-abutment connections has influence on mechanical properties and biological characteristics of implants. There are two types of implant-abutment connections, the external and the internal connections. Morse taper connection is one of the internal connections and its conical shape creates significant friction via the high propensity of parallelism between the two structures within the joint space...
January 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28068564/distinct-patterns-of-increased-translocator-protein-in-posterior-cortical-atrophy-and-amnestic-alzheimer-s-disease
#8
William C Kreisl, Chul Hyoung Lyoo, Jeih-San Liow, Joseph Snow, Emily Page, Kimberly J Jenko, Cheryl L Morse, Sami S Zoghbi, Victor W Pike, R Scott Turner, Robert B Innis
We sought to determine whether patients with posterior cortical atrophy (PCA) demonstrate a pattern of binding to translocator protein 18 kDa, a marker of microglial activation, that is distinct from that in patients with amnestic presentation of Alzheimer's disease (AD). Eleven PCA patients, 11 amnestic AD patients, and 15 age-matched controls underwent positron emission tomography with (11)C-PBR28 to measure translocator protein 18 kDa. PCA patients showed greater (11)C-PBR28 binding than controls in occipital, posterior parietal, and temporal regions...
December 16, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/28068275/influence-of-indexed-abutments-on-the-fracture-resistance-of-internal-conical-dental-implants
#9
Karla Zancopé, Caio César Dias Resende, Lucas Nascimento Tavares, Flávio Domingues das Neves
The aim of this study was to evaluate the influence of abutments with a prosthetic index on the fracture resistance of Morse taper dental implants. Morse taper implants were divided into 2 groups (n = 5 per group): a group with an indexed implant and a nonindexed abutment (solid Morse taper universal post; WIS group), and a group with an indexed implant and an indexed abutment (WIP group). Both groups were subjected to bending tests for fracture strength until 5 mm of displacement or implant fracture occurred...
January 2017: General Dentistry
https://www.readbyqxmd.com/read/28067863/dynamic-features-of-the-highly-excited-vibrational-states-of-the-hocl-non-integrable-system-based-on-the-dynamic-potential-and-lyapunov-exponent-approaches
#10
Aixing Wang, Chao Fang, Yibao Liu
In this article the dynamic features of the highly excited vibrational states of the hypochlorous acid (HOCl) non-integrable system are studied using the dynamic potential and Lyapunov exponent approaches. On the condition that the 3:1 resonance between the H-O stretching and H-O-Cl bending modes accompany the 2:1 Fermi resonance between the O-Cl stretching and H-O-Cl bending modes, it is found that the dynamic potentials of the highly excited vibrational states vary regularly with different Polyad numbers (P numbers)...
January 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28060911/resting-energy-expenditure-in-adults-with-becker-s-muscular-dystrophy
#11
Matthew F Jacques, Paul Orme, Jonathon Smith, Christopher I Morse
PURPOSE: The purpose of this study was: 1) To compare Resting energy expenditure (REE) in adult males with Becker's Muscular Dystrophy (BeMD, n = 21, 39 ±12 years) and healthy controls (CTRL, n = 12, 37 ±12 years) 2) Determine whether other physiological parameters correlate with REE in BeMD, and 3) Compare current prediction methods of REE with measured REE. METHODS: REE was calculated via indirect calorimetry using continuous, expired gas analysis following an overnight fast...
2017: PloS One
https://www.readbyqxmd.com/read/28060252/transduction-transplantation-mouse-model-of-myeloproliferative-neoplasm
#12
Thanh Kim Nguyen, Sarah J Morse, Angela G Fleischman
Transduction-transplantation is a quick and efficient way to model human hematologic malignancies in mice. This technique results in expression of the gene of interest in hematopoietic cells and can be used to study the gene's role in normal and/or malignant hematopoiesis. This protocol provides a detailed description on how to perform transduction-transplantation using calreticulin (CALR) mutations recently identified in myeloproliferative neoplasm (MPN) as an example. In this protocol whole bone marrow cells from 5-flurouracil (5-FU) treated donor mice are transduced with a retrovirus encoding mutant CALR and transplanted into lethally irradiated syngeneic hosts...
December 22, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28049858/high-throughput-phenotyping-of-maize-leaf-physiological-and-biochemical-traits-using-hyperspectral-reflectance
#13
Craig R Yendrek, Tiago Tomaz, Christopher M Montes, Youyuan Cao, Alison M Morse, Patrick J Brown, Lauren M McIntyre, Andrew D B Leakey, Elizabeth A Ainsworth
High-throughput, noninvasive field phenotyping has revealed genetic variation in crop morphological, developmental, and agronomic traits, but rapid measurements of the underlying physiological and biochemical traits are needed to fully understand genetic variation in plant-environment interactions. This study tested the application of leaf hyperspectral reflectance (λ = 500-2,400 nm) as a high-throughput phenotyping approach for rapid and accurate assessment of leaf photosynthetic and biochemical traits in maize (Zea mays)...
January 2017: Plant Physiology
https://www.readbyqxmd.com/read/28048872/we-fg-bra-10-radiodosimetry-of-a-novel-alpha-particle-therapy-targeted-to-uveal-melanoma-absorbed-dose-to-organs-in-mice
#14
Christopher J Tichacek, Narges K Tafreshi, Mikalai M Budzevich, Epifanio Ruiz, Thaddeus J Wadas, Mark L McLaughlin, Eduardo G Moros, David L Morse
PURPOSE: The melanocortin-1 receptor (MC1R) is expressed in 94% of uveal melanomas and is described as an ideal target for this untreatable disease. MC1RL is a high affinity MC1R specific peptidomimetic ligand that can serve as a scaffold for therapeutic conjugates such as alpha particle emitting isotopes. The purpose of this study was to assess normal tissue distribution and risk as a result of using the DOTA chelator conjugated to MC1RL to deliver (225) Ac: MC1RL-DOTA-(225) Ac. METHODS: 17 non-tumor bearing BALB/c mice were intravenously injected with the novel MC1RL-DOTA-(225) Ac radiopharmaceutical with an average initial administered activity of 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047853/su-c-204-03-dft-calculations-of-the-stability-of-dota-based-radiopharmaceuticals
#15
A R Khabibullin, A Karolak, M M Budzevich, L M Woods, M V Martinez, M L McLaughlin, D L Morse
PURPOSE: Application of the density function theory (DFT) to investigate the structural stability of complexes applied in cancer therapy consisting of the 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelated to Ac225, Fr221, At217, Bi213, and Gd68 radio-nuclei. METHODS: The possibility to deliver a toxic payload directly to tumor cells is a highly desirable aim in targeted alpha particle therapy. The estimation of bond stability between radioactive atoms and the DOTA chelating agent is the key element in understanding the foundations of this delivery process...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045752/a-64-year-old-woman-with-an-atrophic-plaque-on-the-thigh-answer
#16
Meredith O Morse, Alejandro A Gru, Jessica Kaffenberger
No abstract text is available yet for this article.
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28045750/a-64-year-old-woman-with-an-atrophic-plaque-on-the-thigh-question
#17
Meredith O Morse, Alejandro A Gru, Jessica Kaffenberger
No abstract text is available yet for this article.
January 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28039082/intraoperative-cerebral-oxygenation-oxidative-injury-and-delirium-following-cardiac-surgery
#18
Marcos G Lopez, Pratik Pandharipande, Jennifer Morse, Matthew S Shotwell, Ginger L Milne, Mias Pretorius, Andrew D Shaw, L Jackson Roberts, Frederic T Billings
BACKGROUND: Delirium affects 20-30% of patients after cardiac surgery and is associated with increased mortality and persistent cognitive decline. Hyperoxic reperfusion of ischemic tissues increases oxidative injury, but oxygen administration remains high during cardiac surgery. We tested the hypothesis that intraoperative hyperoxic cerebral reperfusion is associated with increased postoperative delirium and that oxidative injury mediates this association. METHODS: We prospectively measured cerebral oxygenation with bilateral oximetry monitors in 310 cardiac surgery patients, quantified intraoperative hyperoxic cerebral reperfusion by measuring the magnitude of cerebral oxygenation above baseline after any ischemic event, and assessed patients for delirium twice daily in the ICU following surgery using the confusion assessment method for ICU (CAM-ICU)...
December 27, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28028592/the-quantification-of-short-chain-chlorinated-paraffins-in-sediment-samples-using-comprehensive-two-dimensional-gas-chromatography-with-%C3%AE-ecd-detection
#19
Alina M Muscalu, Dave Morse, Eric J Reiner, Tadeusz Górecki
The analysis of persistent organic pollutants in environmental samples is a challenge due to the very large number of compounds with varying chemical and physical properties. Chlorinated paraffins (CPs) are complex mixtures of chlorinated n-alkanes with varying chain lengths (C10 to C30) and degree of chlorination (30 to 70% by weight). Their physical-chemical properties make these compounds persistent in the environment and able to bioaccumulate in living organisms. Comprehensive two-dimensional gas chromatography (GC × GC) coupled with micro-electron capture detection (μECD) was used to separate and quantify short-chain chlorinated paraffins (SCCP) in sediment samples...
December 27, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28007719/evaluation-of-the-medication-fall-risk-score
#20
Cyrus Yazdani, Scott Hall
PURPOSE: Results of a study evaluating the predictive validity of a fall screening tool in hospitalized patients are reported. METHODS: Administrative claims data from two hospitals were analyzed to determine the discriminatory ability of the "medication fall risk score" (RxFS), a medication review fall-risk screening tool that is designed for use in conjunction with nurse-administered tools such as the Morse Fall Scale (MFS). Through analysis of data on administered medications and documented falls in a population of adults who underwent fall-risk screening at hospital admission over a 15-month period (n = 33,058), the predictive value of admission MFS scores, alone or in combination with retrospectively calculated RxFS-based risk scores, was assessed...
January 1, 2017: American Journal of Health-system Pharmacy: AJHP
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