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https://www.readbyqxmd.com/read/28727987/associations-of-autoimmunity-immunodeficiency-lymphomagenesis-and-gut-microbiota-in-mice-with-knockins-for-a-pathogenic-autoantibody
#1
Shweta Jain, Jerrold M Ward, Dong-Mi Shin, Hongsheng Wang, Zohreh Naghashfar, Alexander L Kovalchuk, Herbert C Morse
A number of mouse strains transgenic for B-cell receptors specific for nucleic acids or other autoantigens have been generated to understand how autoreactive B cells are regulated in normal and autoimmune mice. Previous studies of nonautoimmune C57BL/6 mice heterozygous for both the IgH and IgL knockins of the polyreactive autoantibody, 564, produced high levels of autoantibodies in a largely Toll-like receptor 7-dependent manner. Herein, we describe studies of mice homozygous for the knockins that also expressed high levels of autoantibodies but, unlike the heterozygotes, exhibited a high incidence of mature B-cell lymphomas and enhanced susceptibility to bacterial infections...
July 17, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28725497/effect-of-screw-perpendicularity-on-compression-in-scaphoid-waist-fractures
#2
Morgan M Swanstrom, Kyle W Morse, Joseph D Lipman, Krystle A Hearns, Michelle G Carlson
Background  Central and perpendicular (PERP) screw orientations have each been described for scaphoid fracture fixation. It is unclear, however, which orientation produces greater compression. Questions/Purposes  This study compares compression in scaphoid waist fractures with screw fixation in both PERP and pole-to-pole (PTP) configurations. PERP orientation was hypothesized to produce greater compression than PTP orientation. Methods  Ten preoperative computed tomography scans of scaphoid waist fractures were classified by fracture type and orientation in the coronal and sagittal planes...
August 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28718468/dna-melting-in-the-presence-of-molecular-crowders
#3
Amar Singh, Navin Singh
We study the opening of double stranded DNA (dsDNA) in the presence of molecular crowders using the Peyrard-Bishop-Dauxois (PBD) model. It is a known fact that about 15-20% of the total volume of a cell is occupied by molecular crowders. The presence of crowders in the model is represented through the potential depth in the Morse potential. Using equilibrium statistical calculations we find the melting profile and the melting probabilities of the chain. We found that the melting temperature, Tm, increases in the presence of a crowder...
July 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28714437/the-pragmatic-utility-of-watson-based-caring-measures
#4
Huda Atiyeh, Muayyad Ahmad, Eman Tariq Alslman, Manar Ali Bani Hani
PURPOSE: This study aims to clarify the caring concept with emphasis on the pragmatic utility of caring measures. METHOD: The Morse et al. (Morse, Hupcey, Mitcham, & Lenz, 1996; Morse, Mitcham, Hupcey, & Tasón, 1996) criteria for concept maturity were used as a framework. A literature review of Watson-based caring concept was undertaken to evaluate the logical, epistemological, linguistical, and pragmatic parameters. RESULTS: The concept of caring as conceptualized by Watson and operationalized through different measures appeared mature...
December 1, 2016: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28710250/near-infrared-1064-nm-laser-modulates-migratory-dendritic-cells-to-augment-the-immune-response-to-intradermal-influenza-vaccine
#5
Kaitlyn Morse, Yoshifumi Kimizuka, Megan P K Chan, Mai Shibata, Yusuke Shimaoka, Shu Takeuchi, Benjamin Forbes, Christopher Nirschl, Binghao Li, Yang Zeng, Roderick T Bronson, Wataru Katagiri, Ayako Shigeta, Ruxandra F Sîrbulescu, Huabiao Chen, Rhea Y Y Tan, Kosuke Tsukada, Timothy Brauns, Jeffrey Gelfand, Ann Sluder, Joseph J Locascio, Mark C Poznansky, Niroshana Anandasabapathy, Satoshi Kashiwagi
Brief exposure of skin to near-infrared (NIR) laser light has been shown to augment the immune response to intradermal vaccination and thus act as an immunologic adjuvant. Although evidence indicates that the NIR laser adjuvant has the capacity to activate innate subsets including dendritic cells (DCs) in skin as conventional adjuvants do, the precise immunological mechanism by which the NIR laser adjuvant acts is largely unknown. In this study we sought to identify the cellular target of the NIR laser adjuvant by using an established mouse model of intradermal influenza vaccination and examining the alteration of responses resulting from genetic ablation of specific DC populations...
July 14, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28709795/a-biomechanical-comparison-of-extensor-carpi-ulnaris-subsheath-reconstruction-techniques
#6
Sameer K Puri, Kyle W Morse, Krystle A Hearns, Michelle G Carlson
PURPOSE: Several surgical stabilization techniques have been described to address pathological subluxation of the extensor carpi ulnaris (ECU) tendon, with no comparative data available. This study compares ECU stability after subsheath reconstruction, with and without ulnar groove deepening, to stability with an intact subsheath in a cadaveric model. METHODS: Position of the ECU tendon relative to the ulnar groove was measured in 5 human cadaveric specimens with the subsheath intact, sectioned, and after 3 reconstruction scenarios: reconstructed, reconstructed with ulnar groove deepened, and ulnar groove deepened with subsheath sectioned...
July 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28708914/misfit-of-three-different-implant-abutment-connections-before-and-after-cyclic-load-application-an-in-vitro-study
#7
Sergio Alexandre Gehrke, Rafael Arcesio Delgado-Ruiz, Juan Carlos Prados Frutos, María Prados-Privado, Berenice Anina Dedavid, Jose Manuel Granero Marín, José Luiz Calvo Guirado
PURPOSE: This study aimed to evaluate the misfit of three different implant-abutment connections before and after cycling load. MATERIALS AND METHODS: One hundred twenty dental implants and correspondent prefabricated titanium abutments were used. Three different implant-abutment connections were evaluated: Morse taper (MT group), external hexagon (EH group), and internal hexagon (IH group). Forty implants and 40 abutments were used per group. The parameters for the mechanical evaluation were set as: 360,000 cycles, load of 150 N, and frequency of 4 Hz...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28708912/finite-element-analysis-of-bone-stress-in-the-posterior-mandible-using-regular-and-short-implants-in-the-same-context-with-splinted-and-nonsplinted-prostheses
#8
Marcelo Bighetti Toniollo, Ana Paula Macedo, Denise Pupim, Danilo Zaparolli, Maria da Gloria Chiarello de Mattos
PURPOSE: The aim of this study was to compare the bone stress generated by rehabilitation using regular and short-length Morse taper implants (11 and 5 mm, respectively) in the same context and allied with splinted (SP) and nonsplinted (NSP) prostheses in the posterior area of the mandible using finite element analysis. MATERIALS AND METHODS: Three-dimensional geometric models using regular implants (Ø4 × 11 mm) and short implants (Ø4 × 5 mm) were simulated with a left posterior mandible that had the first premolar tooth and all teeth posterior to that premolar removed...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28708909/biomechanical-three-dimensional-finite-element-analysis-of-single-implant-supported-prostheses-in-the-anterior-maxilla-with-different-surgical-techniques-and-implant-types
#9
Fellippo Ramos Verri, Joel Ferreira Santiago, Daniel Augusto Almeida, Victor Eduardo de Souza Batista, Cleidiel Aparecido Araujo Lemos, Caroline Cantieri Mello, Eduardo Piza Pellizzer
PURPOSE: The aim of this study was to use three-dimensional finite element analysis to analyze the stress distribution transferred by single implant-supported prostheses placed in the anterior maxilla using different connections (external hexagon, internal hexagon, or Morse taper), inclinations of the load (0, 30, or 60 degrees), and surgical techniques for placement (monocortical/conventional, bicortical, or bicortical with nasal floor elevation). MATERIALS AND METHODS: Nine models representing a bone block of this region were simulated by computer-aided design software (InVesalius, Rhinoceros, SolidWorks)...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28691474/cone-morse-implant-connection-system-significantly-reduces-bacterial-leakage-between-implant-and-abutment-an-in-vitro-study
#10
A Baj, A Bolzoni, A Russillo, D Lauritano, A Palmieri, F Cura, F J Silvestre, A B Giannì
Osseointegrated implants are very popular dental treatments today in the world. In osseointegrated implants, the occlusal forces are transmitted from prosthesis through an abutment to a dental implant. The abutment is connected to the implant by mean of a screw. A screw is the most used mean for connecting an implant to an abutment. Frequently the screws break and are lost. There is an alternative to screw retained abutment systems: the cone-morse connection (CMC). The CMC, thanks to the absence of the abutment screw, guarantees no micro-gaps, no micro-movements, and a reduction of bacterial leakage between implant and abutment...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28686473/improving-outcomes-for-homeless-people-with-alcohol-disorders-a-multi-program-community-based-approach
#11
Gary A Morse, Mary M York, Nathaniel Dell, Julie Blanco, Chelsea Birchmier
BACKGROUND: Relatively few community-based programs have been found to be helpful for homeless people with alcohol disorders, even though this group represents a high-risk, vulnerable population prone to poor outcomes. AIMS: This study sought to implement and evaluate intensive community-based programs for homeless people with alcohol disorders. METHOD: The project worked closely with a homeless outreach team for referrals, and then provided two different, intensive substance abuse treatment approaches matched to the needs of two subgroups: homeless individuals with alcohol disorders without severe mental illness received community reinforcement approach (CRA) and case management services, while those with alcohol and severe mental illness were assigned to assertive community treatment and integrated dual disorders (ACT/IDDT) services...
July 7, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28680745/vaccination-targeting-human-her3-alters-the-phenotype-of-infiltrating-t-cells-and-responses-to-immune-checkpoint-inhibition
#12
Takuya Osada, Michael A Morse, Amy Hobeika, Marcio A Diniz, William R Gwin, Zachary Hartman, Junping Wei, Hongtao Guo, Xiao-Yi Yang, Cong-Xiao Liu, Kensuke Kaneko, Gloria Broadwater, H Kim Lyerly
Expression of human epidermal growth factor family member 3 (HER3), a critical heterodimerization partner with EGFR and HER2, promotes more aggressive biology in breast and other epithelial malignancies. As such, inhibiting HER3 could have broad applicability to the treatment of EGFR- and HER2-driven tumors. Although lack of a functional kinase domain limits the use of receptor tyrosine kinase inhibitors, HER3 contains antigenic targets for T cells and antibodies. Using novel human HER3 transgenic mouse models of breast cancer, we demonstrate that immunization with recombinant adenoviral vectors encoding full length human HER3 (Ad-HER3-FL) induces HER3-specific T cells and antibodies, alters the T cell infiltrate in tumors, and influences responses to immune checkpoint inhibitions...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28679428/using-participatory-methods-to-design-an-mhealth-intervention-for-a-low-income-country-a-case-study-in-chikwawa-malawi
#13
Rebecca Laidlaw, Diane Dixon, Tracy Morse, Tara K Beattie, Save Kumwenda, Grant Mpemberera
BACKGROUND: mHealth holds the potential to educate rural communities in developing countries such as Malawi, on issues which over-burdened and under staffed health centres do not have the facilities to address. Previous research provides support that mHealth could be used as a vehicle for health education campaigns at a community level; however the limited involvement of potential service users in the research process endangers both user engagement and intervention effectiveness. METHODS: This two stage qualitative study used participatory action research to inform the design and development of an mHealth education intervention...
July 5, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28668028/accelerating-self-consistent-field-theory-of-block-polymers-in-a-variable-unit-cell
#14
Akash Arora, David C Morse, Frank S Bates, Kevin D Dorfman
Self-consistent field theory (SCFT) is one of the most widely used tools to study the equilibrium phase behavior of block polymers. We have extended an existing version of the Anderson-mixing iteration scheme to solve the highly nonlinear SCFT equations while simultaneously optimizing the unit-cell dimensions. This improved scheme substantially increases the computational efficiency compared to existing schemes.
June 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28662343/effect-of-chronic-%C3%AE-hydroxybutyrate-ghb-administration-on-ghb-toxicokinetics-and-ghb-induced-respiratory-depression
#15
Bridget L Morse, Gurkishan S Chadha, Melanie A Felmlee, Kristin E Follman, Marilyn E Morris
BACKGROUND: γ-hydroxybutyrate (GHB) has a high potential for illicit use; overdose of this compound results in sedation, respiratory depression and death. Tolerance to the hypnotic/sedative and electroencephalogram effects of GHB occurs with chronic GHB administration; however, tolerance to respiratory depression has not been evaluated. GHB toxicodynamic effects are mediated predominantly by GABAB receptors. Chronic treatment may affect monocarboxylate transporters (MCTs) and alter the absorption, renal clearance and brain uptake of GHB...
June 29, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28657965/fatty-liver-disease-in-hiv-common-underappreciated-and-understudied
#16
Caryn G Morse
No abstract text is available yet for this article.
July 17, 2017: AIDS
https://www.readbyqxmd.com/read/28654570/fear-and-risk-of-falling-activities-of-daily-living-and-quality-of-life-assessment-when-older-adults-receive-emergency-department-care
#17
Tuğba Çinarli, Zeliha Koç
BACKGROUND: Falls tend to create fear and concern in older adults who also seek care in emergency departments (EDs) at high rates. AIM: The purposes of this study were to (a) describe risk and fear of falling in older adults seeking care in the ED and (b) explore relationships between risk and fear of falling with activities of daily living and quality of life. METHODS: The study was conducted in the ED of Ondokuz Mayis University Hospital in Samsun, Turkey...
July 2017: Nursing Research
https://www.readbyqxmd.com/read/28651792/racial-and-ethnic-differences-in-contraception-use-and-obstetric-outcomes-a-review
#18
REVIEW
Andrea V Jackson, Lin-Fan Wang, Jessica Morse
In the United States, racial and ethnic minority women experience higher rates of contraceptive non-use, failure, unintended pregnancy, and lower use of long-acting reversible contraception (LARC), compared to whites. Simultaneously researchers have found that unintended pregnancy is associated with poor pregnancy outcomes and pregnancy behaviors, including pre-term birth and late initiation of prenatal care, respectively. Due to the association of pregnancy intention and obstetrical outcomes, public health efforts have focused on the increase in contraception use among these populations as a way to decrease poor pregnancy outcomes...
June 23, 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28650483/disease-model-discovery-from-3-328-gene-knockouts-by-the-international-mouse-phenotyping-consortium
#19
Terrence F Meehan, Nathalie Conte, David B West, Julius O Jacobsen, Jeremy Mason, Jonathan Warren, Chao-Kung Chen, Ilinca Tudose, Mike Relac, Peter Matthews, Natasha Karp, Luis Santos, Tanja Fiegel, Natalie Ring, Henrik Westerberg, Simon Greenaway, Duncan Sneddon, Hugh Morgan, Gemma F Codner, Michelle E Stewart, James Brown, Neil Horner, Melissa Haendel, Nicole Washington, Christopher J Mungall, Corey L Reynolds, Juan Gallegos, Valerie Gailus-Durner, Tania Sorg, Guillaume Pavlovic, Lynette R Bower, Mark Moore, Iva Morse, Xiang Gao, Glauco P Tocchini-Valentini, Yuichi Obata, Soo Young Cho, Je Kyung Seong, John Seavitt, Arthur L Beaudet, Mary E Dickinson, Yann Herault, Wolfgang Wurst, Martin Hrabe de Angelis, K C Kent Lloyd, Ann M Flenniken, Lauryl M J Nutter, Susan Newbigging, Colin McKerlie, Monica J Justice, Stephen A Murray, Karen L Svenson, Robert E Braun, Jacqueline K White, Allan Bradley, Paul Flicek, Sara Wells, William C Skarnes, David J Adams, Helen Parkinson, Ann-Marie Mallon, Steve D M Brown, Damian Smedley
Although next-generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies are still limited by a lack of knowledge of the functions and pathobiological mechanisms of most genes. To address this challenge, the International Mouse Phenotyping Consortium is creating a genome- and phenome-wide catalog of gene function by characterizing new knockout-mouse strains across diverse biological systems through a broad set of standardized phenotyping tests...
June 26, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28640610/the-role-of-denitrification-in-stormwater-detention-basin-treatment-of-nitrogen
#20
Natalie R Morse, Lauren E McPhillips, James P Shapleigh, M Todd Walter
The nitrogen (N) cycling dynamics of four stormwater basins, two often saturated sites ("Wet Basins") and two quick draining sites ("Dry Basins"), were monitored over a ∼ 1-year period. This study paired stormwater and greenhouse gas monitoring with microbial analyses to elucidate the mechanisms controlling N treatment. Annual dissolved inorganic N (DIN) mass reductions (inflow minus outflow) were greater in the Dry Basin than in the Wet Basin, 2.16 vs 0.75 g N m(-2) yr(-1), respectively. The Dry Basin infiltrated a much larger volume of water and thus had greater DIN mass reductions, even though incoming and outgoing DIN concentrations were statistically the same for both sites...
July 6, 2017: Environmental Science & Technology
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