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https://www.readbyqxmd.com/read/28916462/causation-constructors-and-codes
#1
Jan-Hendrik S Hofmeyr
Relational biology relies heavily on the enriched understanding of causal entailment that Robert Rosen's formalisation of Aristotle's four causes has made possible, although to date efficient causes and the rehabilitation of final cause have been its main focus. Formal cause has been paid rather scant attention, but, as this paper demonstrates, is crucial to our understanding of many types of processes, not necessarily biological. The graph-theoretic relational diagram of a mapping has played a key role in relational biology, and the first part of the paper is devoted to developing an explicit representation of formal cause in the diagram and how it acts in combination with efficient cause to form a mapping...
September 12, 2017: Bio Systems
https://www.readbyqxmd.com/read/28914708/efficacy-of-femiscan-pelvic-floor-therapy-for-the-treatment-of-anal-incontinence
#2
Shimon Segal, Abraham Morse, Purnima Sangal, Nathan Hirsch, Neeraj Kohli
OBJECTIVES: Pelvic floor muscle training can be effective in alleviating anal incontinence; however, women need instruction, motivation, and feedback to gain optimal benefit. The FemiScan Pelvic Floor Therapy System is approved in the United States and European Union for the treatment of urinary incontinence. It uses office electromyography and an in-home programmable device. This study was undertaken to document the effect of FemiScan on anal incontinence symptoms of women who completed a physician-supervised program...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28903461/comparative-genomics-reveals-two-major-bouts-of-gene-retroposition-coinciding-with-crucial-periods-of-symbiodinium-evolution
#3
Bo Song, David Morse, Yue Song, Yuan Fu, Xin Lin, Wenliang Wang, Shifeng Cheng, Wenbin Chen, Xin Liu, Senjie Lin
Gene retroposition is an important mechanism of genome evolution but the role it plays in dinoflagellates, a critical player in marine ecosystems, is not known. Until recently, when the genomes of two coral-symbiotic dinoflagellate genomes, Symbiodinium kawagutii and S. minutum, were released, it has not been possible to systematically study these retrogenes. Here we examine the abundant retrogenes (∼23% of the total genes) in these species. The hallmark of retrogenes in the genome is the presence of DCCGTAGCCATTTTGGCTCAAG, a spliced leader (DinoSL) constitutively trans-spliced to the 5'-end of all nucleus-encoded mRNAs...
August 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28902795/magnetic-resonance-imaging-of-neuroendocrine-tumor-hepatic-metastases-does-hepatobiliary-phase-imaging-improve-lesion-conspicuity-and-interobserver-agreement-of-lesion-measurements
#4
Brian Morse, Daniel Jeong, Kerry Thomas, Dalanda Diallo, Jonathan R Strosberg
OBJECTIVE: The aim of this study was to determine if magnetic resonance imaging (MRI) performed with hepatobiliary phase imaging results in higher lesion conspicuity and produces lesion measurements with higher interobserver agreement than other MRI sequences when imaging neuroendocrine hepatic metastases. METHODS: Patients who had MRIs with both gadoxetate disodium and gadopentetate dimeglumine contrast within a 6-month span were identified, and 23 hepatic lesions were selected...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28900644/properties-of-kinetic-transition-networks-for-atomic-clusters-and-glassy-solids
#5
John W R Morgan, Dhagash Mehta, David J Wales
A database of minima and transition states corresponds to a network where the minima represent nodes and the transition states correspond to edges between the pairs of minima they connect via steepest-descent paths. Here we construct networks for small clusters bound by the Morse potential for a selection of physically relevant parameters, in two and three dimensions. The properties of these unweighted and undirected networks are analysed to examine two features: whether they are small-world, where the shortest path between nodes involves only a small number or edges; and whether they are scale-free, having a degree distribution that follows a power law...
September 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28889786/implantable-microphones-as-an-alternative-to-external-microphones-for-cochlear-implants
#6
Alistair Mitchell-Innes, Robert Morse, Richard Irving, Philip Begg
Totally implantable cochlear implants may be able to address many of the problems cochlear implant users have around cosmetic appearances, discomfort, and restriction of activities. The major technological challenges that need to be solved to develop a totally implantable device relate to implanted microphone performance. Previous attempts at implanting microphones for cochlear implants have not performed as well as conventional cochlear implant microphones, and in addition have struggled with extraneous body or surface contact noise...
September 11, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28887958/photoelastic-analysis-of-mandibular-full-arch-implant-supported-fixed-dentures-made-with-different-bar-materials-and-manufacturing-techniques
#7
Danilo Zaparolli, Raniel Fernandes Peixoto, Denise Pupim, Ana Paula Macedo, Marcelo Bighetti Toniollo, Maria da Glória Chiarello de Mattos
PURPOSE: To compare the stress distribution of mandibular full dentures supported with implants according to the bar materials and manufacturing techniques using a qualitative photoelastic analysis. MATERIAL AND METHODS: An acrylic master model simulating the mandibular arch was fabricated with four Morse taper implant analogs of 4.5×6mm. Four different bars were manufactured according to different material and techniques: fiber-reinforced resin (G1, Trinia, CAD/CAM), commercially pure titanium (G2, cpTi, CAD/CAM), cobalt‑chromium (G3, Co-Cr, CAD/CAM) and cobalt‑chromium (G4, Co-Cr, conventional cast)...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28884844/an-open-label-clinical-trial-assessing-the-efficacy-and-safety-of-bend-skincare-anti-aging-formula-on-minimal-erythema-dose-in-skin
#8
Nancy L Morse, Anna-Jean Reid, Marc St-Onge
BACKGROUND/PURPOSE: Sunburn and other health risks associated with excess sun exposure place huge economic burdens on societies, and create discomfort and disease within susceptible individuals. Oral supplements that reduce sunburn may be advantageous. This study evaluated the safety and efficacy of Bend Skincare Anti-Aging Formula to ameliorate sunburn induced with a solar simulator. METHODS: Subjects (n= 28) with Fitzpatrick skin phototypes I, II or III took four capsules daily of the supplement providing 1400 mg of eicosapentaenoic acid (EPA)+ docosahexaenoic acid (DHA), 120 mg of gamma-linolenic acid (GLA), 5 mg of lutein, 2...
September 8, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28884841/sclerostin-antibody-enhances-bone-formation-in-a-rat-model-of-distraction-osteogenesis
#9
Michelle M McDonald, Alyson Morse, Oliver Birke, Nicole Yc Yu, Kathy Mikulec, Lauren Peacock, Aaron Schindeler, Min Liu, Hua Zhu Ke, David G Little
Neutralizing monoclonal sclerostin antibodies are effective in promoting bone formation at a systemic level and in orthopedic scenarios including closed fracture repair. In this study we examined the effects of sclerostin antibody (Scl-Ab) treatment on regenerate volume, density and strength in a rat model of distraction osteogenesis. Surgical osteotomy was performed on 179 Sprague Dawley rats. After 1 week, rats underwent distraction for 2 weeks, followed by 6 weeks for consolidation. Two treatment groups received biweekly subcutaneous Scl-AbIII (a rodent form of Scl-Ab; 25 mg/kg), either from the start of distraction onwards or restricted to the consolidation phase...
September 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28880201/decrease-in-healthcare-utilization-and-costs-for-opioid-users-following-residential-integrated-treatment-for-co-occurring-disorders
#10
Siobhan Morse, Brian E Bride
BACKGROUND: Opioid use results in higher healthcare utilization and costs, particularly among those with co-occurring mental health disorders. Presumably, effective treatment would result in a reduction in healthcare utilization and costs. To date, research has not examined this question. As such, the purpose of this study was to estimate and compare pre- and post-treatment healthcare utilization and costs for individuals receiving residential integrated treatment for co-occurring mental health and opioid use disorders...
September 7, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28877610/the-tumor-suppressive-role-of-inhibin-%C3%AE-a-in-diffuse-large-b-cell-lymphoma
#11
Lei Jiang, Ting Si, Mei Yu, Xinli Zeng, Herbert C Morse, Ying Lu, Guifang Ouyang, Jeff X Zhou
INHBA (inhibin βA), a subunit of a ligand of the transforming growth factor-β superfamily, is known to play diverse roles in various solid tumors. However, its role in hematologic malignancies remains unexplored. Here, we investigated the function of INHBA in diffuse large B-cell lymphoma (DLBCL). Both mRNA and protein levels of INHBA were significantly downregulated in primary DLBCL tissues, irrespective of germinal center B-cell-like (GCB) or non-GCB subtype, compared to those in benign tonsils. The low level of INHBA in patients with de novo DLBCL was correlated with reduced overall and progression-free survival...
September 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28875397/boceprevir-and-antiretroviral-pharmacokinetic-interactions-in-hiv-hcv-co-infected-persons-aids-clinical-trials-group-study-a5309s
#12
Jennifer J Kiser, Darlene Lu, Susan L Rosenkranz, Gene D Morse, Robin DiFrancesco, Kenneth E Sherman, Adeel A Butt
OBJECTIVE: The objective of this study was to determine the magnitude of drug interactions between the hepatitis C virus (HCV) protease inhibitor boceprevir (BOC) and antiretroviral (ARV) agents in persons with HIV/HCV co-infection. METHODS: Participants taking two nucleos(t)ide analogs with either efavirenz, raltegravir, or ritonavir-boosted atazanavir, darunavir, or lopinavir underwent intensive pharmacokinetic (PK) sampling for ARV 2 weeks before (week 2) and 2 weeks after initiating BOC (week 6) and for BOC at week 6...
September 5, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28866503/the-topology-toolkit
#13
Julien Tierny, Guillaume Favelier, Joshua A Levine, Charles Gueunet, Michael Michaux
This system paper presents the Topology ToolKit (TTK), a software platform designed for the topological analysis of scalar data in scientific visualization. While topological data analysis has gained in popularity over the last two decades, it has not yet been widely adopted as a standard data analysis tool for end users or developers. TTK aims at addressing this problem by providing a unified, generic, efficient, and robust implementation of key algorithms for the topological analysis of scalar data, including: critical points, integral lines, persistence diagrams, persistence curves, merge trees, contour trees, Morse-Smale complexes, fiber surfaces, continuous scatterplots, Jacobi sets, Reeb spaces, and more...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28865169/a-developmental-based-motivational-intervention-to-reduce-alcohol-and-marijuana-use-among-non-treatment-seeking-young-adults-a-randomized-controlled-trial
#14
Michael D Stein, Celeste M Caviness, Emily F Morse, Kristin R Grimone, Daniel Audet, Debra S Herman, Ethan Moitra, Bradley J Anderson
AIMS: To test the hypothesis that among non-treatment-seeking emerging adults (EA) who both use marijuana and have alcohol binges, a brief, longitudinally-delivered, developmentally-based motivational intervention would show greater reductions in the use of these two substances compared with a health education control condition. DESIGN: Parallel, two group, randomized controlled trial with follow-up interventions conducted at 1, 3, 6, and 9 months and final assessments at 12 and 15 months...
September 2, 2017: Addiction
https://www.readbyqxmd.com/read/28863527/bond-dissociation-energies-of-tisi-zrsi-hfsi-vsi-nbsi-and-tasi
#15
Andrew Sevy, Jason J Sorensen, Thomas D Persinger, Jordan A Franchina, Eric L Johnson, Michael D Morse
Predissociation thresholds have been observed in the resonant two-photon ionization spectra of TiSi, ZrSi, HfSi, VSi, NbSi, and TaSi. It is argued that because of the high density of electronic states at the ground separated atom limit in these molecules, the predissociation threshold in each case corresponds to the thermochemical bond dissociation energy. The resulting bond dissociation energies are D0(TiSi) = 2.201(3) eV, D0(ZrSi) = 2.950(3) eV, D0(HfSi) = 2.871(3) eV, D0(VSi) = 2.234(3) eV, D0(NbSi) = 3...
August 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28858813/tactile-morse-code-using-locational-stimulus-identification
#16
Michael Walker, Kyle Brandon Reed
This research investigated several haptic interfaces designed to reduce mistakes in Morse code reception. Results concluded that a bimanual setup, discriminating dots/dashes by left/right location, reduced the amount of errors to only 56.6% of the errors compared to a unimanual setup that used temporal discrimination to distinguish dots and dashes.
August 24, 2017: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28854647/chemical-degradation-of-tmr-multilure-dispensers-for-fruit-fly-detection-weathered-under-california-climatic-conditions
#17
Roger I Vargas, Steven K Souder, Joseph G Morse, Elizabeth E Grafton-Cardwell, David R Haviland, John N Kabashima, Ben A Faber, Bruce Mackey, Eddie Nkomo, Peter J Cook, John D Stark
Degradation models for multilure fruit fly trap dispensers were analyzed to determine their potential for use in large California detection programs. Solid three-component male lure TMR (trimedlure [TML], methyl eugenol [ME], raspberry ketone [RK]) dispensers impregnated with DDVP (2, 2-dichlorovinyl dimethyl phosphate) insecticide placed inside Jackson traps were weathered during summer (8 wk) and winter (12 wk) in five citrus-growing areas. Additionally, TMR wafers without DDVP, but with an insecticidal strip, were compared to TMR dispensers with DDVP...
August 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28852823/a-proteomic-portrait-of-dinoflagellate-chromatin-reveals-abundant-rna-binding-proteins
#18
Mathieu Beauchemin, David Morse
Dinoflagellate chromatin is unique among eukaryotes, as the chromosomes are permanently condensed in a liquid crystal state instead of being packed in nucleosomes. However, how it is organized is still an unsolved mystery, in part due to the lack of a comprehensive catalog of dinoflagellate nuclear proteins. Here, we report the results of CHromatin Enrichment for Proteomics (CHEP) followed by shotgun mass spectrometry sequencing of the chromatin-associated proteins from the dinoflagellate Lingulodinum polyedra...
August 29, 2017: Chromosoma
https://www.readbyqxmd.com/read/28837562/interventions-to-address-unequal-gender-and-power-relations-and-improve-self-efficacy-and-empowerment-for-sexual-and-reproductive-health-decision-making-for-women-living-with-hiv-a-systematic-review
#19
Jennifer L Robinson, Manjulaa Narasimhan, Avni Amin, Sophie Morse, Laura K Beres, Ping Teresa Yeh, Caitlin Elizabeth Kennedy
BACKGROUND: Many women living with HIV experience gendered power inequalities, particularly in their intimate relationships, that prevent them from achieving optimal sexual and reproductive health (SRH) and exercising their rights. We assessed the effectiveness of interventions to improve self-efficacy and empowerment of women living with HIV to make SRH decisions through a systematic review. METHODS AND FINDINGS: We included peer-reviewed articles indexed in PubMed, PsycINFO, CINAHL, Embase, and Scopus published through January 3, 2017, presenting multi-arm or pre-post intervention evaluations measuring one of the following outcomes: (1) self-efficacy, empowerment, or measures of SRH decision-making ability, (2) SRH behaviors (e...
2017: PloS One
https://www.readbyqxmd.com/read/28825934/delineating-among-parenting-confidence-parenting-self-efficacy-and-competence
#20
Ashlee J Vance, Debra H Brandon
This article examined the concepts of parenting self-efficacy, parenting confidence, and competence. Using Morse's method of concept delineation, a literature review of each concept was conducted to uncover commonalities, distinctions, and measurement overlaps between concepts and provide conceptual boundaries. Findings revealed that parenting confidence and parenting self-efficacy describe a parents' internal attribution or beliefs about their ability to engage in parenting behaviors. Both terms have similar antecedents, attributes, and consequences, whereas competence is a concept that should be used as an objective measure by someone other than the parent to assess parenting quality...
August 18, 2017: ANS. Advances in Nursing Science
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