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https://www.readbyqxmd.com/read/29775152/semi-automated-application-for-estimating-subthalamic-nucleus-boundaries-and-optimal-target-selection-for-deep-brain-stimulation-implantation-surgery
#1
John A Thompson, Salam Oukal, Hagai Bergman, Steven Ojemann, Adam O Hebb, Sara Hanrahan, Zvi Israel, Aviva Abosch
OBJECTIVE Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become standard care for the surgical treatment of Parkinson's disease (PD). Reliable interpretation of microelectrode recording (MER) data, used to guide DBS implantation surgery, requires expert electrophysiological evaluation. Recent efforts have endeavored to use electrophysiological signals for automatic detection of relevant brain structures and optimal implant target location. The authors conducted an observational case-control study to evaluate a software package implemented on an electrophysiological recording system to provide online objective estimates for entry into and exit from the STN...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29765886/reference-value-for-infrapatellar-branch-of-saphenous-nerve-conduction-study-cadaveric-and-clinical-study
#2
Keon-Tae Kim, Yong-Ki Kim, Jung Ro Yoon, Yundam Ko, Myung Eun Chung
Objective: To determine the optimal stimulation and recording site for infrapatellar branch of saphenous nerve (IPBSN) conduction studies by a cadaveric study, and to confirm that obtained location is practically applicable to healthy adults. Methods: Twelve lower limbs from six cadavers were studied. We defined the optimal stimulation site as the point IPBSN exits the sartorius muscle and the distance or ratio were measured on the X- and Y-axis based on the line connecting the medial and lateral poles of the patella...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29762775/combination-superficial-temporal-artery-middle-cerebral-artery-bypass-and-m2-m2-reanastomosis-with-trapping-of-a-stented-distal-middle-cerebral-artery-aneurysm-3-dimensional-operative-video
#3
Jan-Karl Burkhardt, Sonia Yousef, Halima Tabani, Arnau Benet, Roberto Rodriguez Rubio, Michael T Lawton
Distal middle cerebral artery (MCA) aneurysms often have non-saccular morphology and cannot be clipped, requiring revascularization and trapping instead. Combination bypasses are needed when 2 arteries exit the aneurysm, and extracranial-intracranial and intracranial-intracranial bypasses can be used. This video demonstrates a combination bypass used to treat a previously stented distal MCA aneurysm with both a superficial temporal artery (STA)-to-MCA bypass and an M2-to-M2 reanastomosis. This 56-yr-old man presented with distal left-sided MCA aneurysm 2 years earlier and attempted stent-assisted coiling was aborted after the aneurysm was perforated with stenting alone...
May 12, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29762174/reasons-for-non-adherence-to-the-dapivirine-vaginal-ring-results-of-the-mtn-032-aha-study
#4
Elizabeth T Montgomery, Jonathan Stadler, Sarita Naidoo, Ariana Katz, Nicole Laborde, Morgan Garcia, Krishnaveni Reddy, Leila Mansoor, Juliane Etima, Chifundo Zimba, Miria Chitukuta, Lydia Soto-Torres
OBJECTIVE(S): METHODS:: Former ASPIRE participants were stratified by age group (18-21; 22-45) and randomly selected at seven sites in Malawi, South Africa, Uganda and Zimbabwe, 12-17 months after trial exit. Using in-depth interviews or focus group discussions, ring use barriers were explored using structured guides and visual tools including individual-level depictions of dapivirine levels detected in plasma and returned rings. RESULTS: 187 were enrolled; 37% were 18-21 when they began ASPIRE...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29759537/real-time-localization-of-ventricular-tachycardia-origin-from-the-12-lead-electrocardiogram
#5
John L Sapp, Meir Bar-Tal, Adam J Howes, Jonathan E Toma, Ahmed El-Damaty, James W Warren, Paul J MacInnis, Shijie Zhou, B Milan Horáček
OBJECTIVES: The aim of this study was to develop rapid computational methods for identifying the site of origin of ventricular activation from the 12-lead electrocardiogram. BACKGROUND: Catheter ablation of ventricular tachycardia in patients with structural heart disease frequently relies on a substrate-based approach, which may use pace mapping guided by body-surface electrocardiography to identify culprit exit sites. METHODS: Patients undergoing ablation of scar-related VT (n = 38) had 12-lead electrocardiograms recorded during pacing at left ventricular endocardial sites (n = 1,012) identified on 3-dimensional electroanatomic maps and registered to a generic left ventricular endocardial surface divided into 16 segments and tessellated into 238 triangles; electrocardiographic data were reduced for each lead to 1 variable, consisting of QRS time integral...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759434/pulmonary-vein-re-isolation-as-a-routine-strategy-regardless-of-symptoms-the-pressure-randomized-controlled-trial
#6
Moloy Das, Gareth J Wynn, Yawer Saeed, Sean Gomes, Maureen Morgan, Christina Ronayne, Laura J Bonnett, Johan E P Waktare, Derick M Todd, Mark C S Hall, Richard L Snowdon, Simon Modi, Dhiraj Gupta
OBJECTIVES: The goal of this study was to determine whether a strategy of early re-isolation of pulmonary vein (PV) reconnection in all patients, regardless of symptoms, would reduce the recurrence of atrial fibrillation (AF) and improve quality of life. BACKGROUND: Lasting pulmonary vein isolation (PVI) remains elusive. PV reconnection is strongly linked to the recurrence of arrhythmia. METHODS: A total of 80 patients with paroxysmal AF were randomized 1:1 after contact force-guided PVI to receive either standard care or undergo a repeat electrophysiology study after 2 months regardless of symptoms (repeat study)...
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29757379/quiescin-sulfhydryl-oxidase-1-qsox1-glycosite-mutation-perturbs-secretion-but-not-golgi-localization
#7
Ben Horowitz, Gabriel Javitt, Tal Ilani, Yair Gat, David Morgenstern, Frederic A Bard, Deborah Fass
Quiescin sulfhydryl oxidase 1 (QSOX1) catalyzes the formation of disulfide bonds in protein substrates. Unlike other enzymes with related activities, which are commonly found in the endoplasmic reticulum, QSOX1 is localized to the Golgi apparatus or secreted. QSOX1 is upregulated in quiescent fibroblast cells and secreted into the extracellular environment, where it contributes to extracellular matrix assembly. QSOX1 is also upregulated in adenocarcinomas, though the extent to which it is secreted in this context is currently unknown...
May 11, 2018: Glycobiology
https://www.readbyqxmd.com/read/29754387/low-genetic-diversity-and-low-gene-flow-corresponded-to-a-weak-genetic-structure-of-ruddy-breasted-crake-porzana-fusca-in-china
#8
Chaoying Zhu, Peng Chen, Yuqing Han, Luzhang Ruan
The Ruddy-breasted Crake (Porzana fusca) is an extremely poorly known species. Although it is not listed as globally endangered, in recent years, with the interference of climate change and human activities, its habitat is rapidly disappearing and its populations have been shrinking. There are two different life history traits for Ruddy-breasted Crake in China, i.e., non-migratory population in the south and migratory population in the north of China. In this study, mitochondrial control sequences and microsatellite datasets of 88 individuals sampled from 8 sites were applied to analyze their genetic diversity, genetic differentiation, and genetic structure...
May 12, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29752410/identification-and-structural-characterization-of-a-histidinol-phosphate-phosphatase-from-mycobacterium-tuberculosis
#9
Bhavya Jha, Deepak Kumar, Arun Sharma, Abhisek Dwivedy, Ramandeep Singh, Bichitra Kumar Biswal
The absence of a histidine biosynthesis pathway in humans, coupled with histidine essentiality for survival of the important human pathogen Mycobacterium tuberculosis ( Mtb ), underscores the importance of the bacterial enzymes of this pathway as major anti-tuberculosis drug targets. However, the identity of the mycobacterial enzyme that functions as the histidinol phosphate phosphatase (HolPase) of this pathway remains to be established. Here, we demonstrate that the enzyme encoded by the Rv3137 gene, belonging to the inositol monophosphatase (IMPase) family, functions as the Mtb HolPase and specifically dephosphorylates histidinol phosphate...
May 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29751297/tidal-fluxes-of-mercury-and-methylmercury-for-mendall-marsh-penobscot-river-estuary-maine
#10
R R Turner, C P J Mitchell, A D Kopec, R A Bodaly
Tidal marshes are both important sites of in situ methylmercury production and can be landscape sources of methylmercury to adjacent estuarine systems. As part of a regional investigation of the Hg-contaminated Penobscot River and Bay system, the tidal fluxes of total suspended solids, total mercury and methylmercury into and out of a regionally important mesohaline fluvial marsh complex, Mendall Marsh, were intensively measured over several tidal cycles and at two spatial scales to assess the source-sink function of the marsh with respect to the Penobscot River...
May 8, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29750191/structures-of-monomeric-and-oligomeric-forms-of-the-toxoplasma-gondii-perforin-like-protein-1
#11
Tao Ni, Sophie I Williams, Saša Rezelj, Gregor Anderluh, Karl Harlos, Phillip J Stansfeld, Robert J C Gilbert
Toxoplasma and Plasmodium are the parasitic agents of toxoplasmosis and malaria, respectively, and use perforin-like proteins (PLPs) to invade host organisms and complete their life cycles. The Toxoplasma gondii PLP1 ( Tg PLP1) is required for efficient exit from parasitophorous vacuoles in which proliferation occurs. We report structures of the membrane attack complex/perforin (MACPF) and Apicomplexan PLP C-terminal β-pleated sheet (APCβ) domains of Tg PLP1. The MACPF domain forms hexameric assemblies, with ring and helix geometries, and the APCβ domain has a novel β-prism fold joined to the MACPF domain by a short linker...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29746497/peritoneal-dialysis-related-peritonitis-caused-by-pseudomonas-species-insight-from-a-post-millennial-case-series
#12
Wanhong Lu, Bonnie Ching-Ha Kwan, Kai Ming Chow, Wing-Fai Pang, Chi Bon Leung, Philip Kam-To Li, Cheuk Chun Szeto
BACKGROUND: Pseudomonas peritonitis is a serious complication of peritoneal dialysis (PD). However, the clinical course of Pseudomonas peritonitis following the adoption of international guidelines remains unclear. METHODS: We reviewed the clinical course and treatment response of 153 consecutive episodes of PD peritonitis caused by Pseudomonas species from 2001 to 2015. RESULTS: Pseudomonas peritonitis accounted for 8.3% of all peritonitis episodes...
2018: PloS One
https://www.readbyqxmd.com/read/29733329/effectiveness-of-a-chlorhexidine-dressing-on-silver-coated-external-ventricular-drain-associated-colonization-infection-a-prospective-single-blinded-randomized-controlled-clinical-trial-evdai-study
#13
Michel Roethlisberger, Giusi Moffa, Urs Fisch, Benedikt Wiggli, Stephan Schoen, Christopher Kelly, Severina Leu, Davide Croci, Daniel W Zumofen, Nadine Cueni, Danica Nogarth, Marianne Schulz, Heiner C Bucher, Maja Weisser-Rohacek, Morten-Goetz Wasner, Andreas F Widmer, Luigi Mariani
Background: Observational studies have shown that dressings containing chlorhexidine gluconate (CHX) lower the incidence external ventricular drain (EVD) associated infections (EVDAI). This prospective, randomized controlled trial (RCT) studies the efficacy of CHX-containing dressings in reducing bacterial colonization, which represents an important risk factor for infectious complications. Methods: In this single-site, prospective, double-blinded RCT, patients aged ≥18 undergoing emergency EVD placement were randomly given either a CHX- or an otherwise identical control dressing at the skin exit wound of the EVD...
May 4, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29722286/new-insertion-support-device-assisted-the-accurate-placement-of-tunneled-cuffed-catheter-first-experience-of-10-cases
#14
Toshiaki Ohara, Kazufumi Sakurama, Satoshi Hiramatsu, Toshimasa Karai, Toshiaki Sato, Yuta Nishina
INTRODUCTION: The tunneled cuffed catheter is used in hemodialysis patients for whom an arteriovenous fistula or arteriovenous graft is not suitable or for bridging usage of them. Accurate placement of a tunneled cuffed catheter is necessary for safe hemodialysis, but placement is sometimes difficult because of individual body differences. We developed a new device to support accurate placement of the tunneled cuffed catheter. In this study, we report our first clinical experience of the device...
May 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29720700/in-silico-assessment-of-the-conduction-mechanism-of-the-ryanodine-receptor-1-reveals-previously-unknown-exit-pathways
#15
Leonard P Heinz, Wojciech Kopec, Bert L de Groot, Rainer H A Fink
The ryanodine receptor 1 is a large calcium ion channel found in mammalian skeletal muscle. The ion channel gained a lot of attention recently, after multiple independent authors published near-atomic cryo electron microscopy data. Taking advantage of the unprecedented quality of structural data, we performed molecular dynamics simulations on the entire ion channel as well as on a reduced model. We calculated potentials of mean force for Ba2+ , Ca2+ , Mg2+ , K+ , Na+ and Cl- ions using umbrella sampling to identify the key residues involved in ion permeation...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29712846/ribosome-protection-by-antibiotic-resistance-atp-binding-cassette-protein
#16
Weixin Su, Veerendra Kumar, Yichen Ding, Rya Ero, Aida Serra, Benjamin Sian Teck Lee, Andrew See Weng Wong, Jian Shi, Siu Kwan Sze, Liang Yang, Yong-Gui Gao
The ribosome is one of the richest targets for antibiotics. Unfortunately, antibiotic resistance is an urgent issue in clinical practice. Several ATP-binding cassette family proteins confer resistance to ribosome-targeting antibiotics through a yet unknown mechanism. Among them, MsrE has been implicated in macrolide resistance. Here, we report the cryo-EM structure of ATP form MsrE bound to the ribosome. Unlike previously characterized ribosomal protection proteins, MsrE is shown to bind to ribosomal exit site...
April 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29710837/mechanism-of-the-dual-activities-of-human-cyp17a1-and-binding-to-anti-prostate-cancer-drug-abiraterone-revealed-by-a-novel-v366m-mutation-causing-17-20-lyase-deficiency
#17
Mónica Fernández-Cancio, Núria Camats, Christa E Flück, Adam Zalewski, Bernhard Dick, Brigitte M Frey, Raquel Monné, Núria Torán, Laura Audí, Amit V Pandey
The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. In a 46, XY patient with female external genitalia, together with a loss of function mutation S441P, we identified a novel missense mutation V366M at the catalytic center of CYP17A1 which preferentially impaired 17,20 lyase activity. Kinetic experiments with bacterially expressed proteins revealed that V366M mutant enzyme can bind and metabolize pregnenolone to 17OH-pregnenolone, but 17OH-pregnenolone binding and conversion to dehydroepiandrosterone (DHEA) was impaired, explaining the patient’s steroid profile...
April 29, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29707549/percutaneous-endoscopic-cervical-discectomy-a-technical-review
#18
REVIEW
Javier Quillo-Olvera, Guang-Xun Lin, Jin-Sung Kim
The treatment of cervical disc herniations has evolved in the last 2 decades. While the anterior cervical discectomy and fusion continues being the gold standard for the treatment of radicular pain triggered by cervical disc herniation, other surgical approaches have been developed. Percutaneous endoscopic cervical discectomy has demonstrated the ability to decompress the exiting nerve root and dural sac correctly and encouraging clinical outcomes has been reported in the literature. One of the most important advantages offered by the endoscopic technique is the capability to resolve the patient's symptoms without the need for interbody fusion...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29705911/drilling-through-anteromedial-portal-with-a-femoral-aiming-device-ensures-a-sufficient-length-and-a-proper-graft-position-and-prevents-posterior-wall-breakage-during-anterior-cruciate-ligament-reconstruction
#19
Hasan Bombaci, Faruk Aykanat
OBJECTIVE: The aim of this study was to evaluate the characteristics of the femoral tunnel (FT) which was drilled through the AM portal by using a femoral aimer device and AP stability of the knee. METHODS: Thirty-eight patients, with the mean age 29.6 (range: 20-43) years, were evaluated after ACL reconstruction. The mean follow-up time was 31.9 (range: 16-57) months. The FT was drilled using a femoral aimer with different offset according to the graft size measured, through the AM portal...
April 28, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29705415/rapid-baso-apical-translocation-of-mycobacterium-avium-ssp-paratuberculosis-in-mammary-epithelial-cells-in-the-presence-of-escherichia-coli
#20
D G G Schwarz, F M Shoyama, L L Oliveira, S Sreevatsan, M A S Moreira
Infection of mammary gland cells with bacterial pathogens begins with adhesion, invasion, and persistence within the cells or systemic distribution. Some bacteria, such as Escherichia coli, are known to causes bovine mastitis, resulting in acute proinflammatory responses in the mammary tissue. Mycobacterium avium ssp. paratuberculosis (MAP), the etiological agent of paratuberculosis, is able to spread to distant organs after crossing intestinal cells, reaching the mammary gland and potentially being released in milk, infecting calves during suckling...
April 25, 2018: Journal of Dairy Science
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