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https://www.readbyqxmd.com/read/29148010/experimental-study-on-the-chemico-physical-interaction-between-a-two-component-cyanoacrylate-glue-and-the-material-of-piccs
#1
Francesca Di Puccio, Daniela Giacomarro, Lorenza Mattei, Mauro Pittiruti, Giancarlo Scoppettuolo
INTRODUCTION: The use of cyanoacrylate glue as sealant on the exit site of peripherally inserted central catheters (PICCs) may offer some important clinical advantages. However, concerns exist about the potential interaction between cyanoacrylate and the material of the catheter itself. The aim of this study was to investigate the possibility of damage to the catheter secondary to a long-term contact with a two-component skin glue (N-butyl + octyl cyanoacrylate). METHODS: Twelve PICCs of different brands and types were selected (11 made of polyurethane and one made of silicon)...
November 11, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29148002/targeting-zero-catheter-related-bloodstream-infections-in-pediatric-intensive-care-unit-a-retrospective-matched-case-control-study
#2
Daniele G Biasucci, Mauro Pittiruti, Alessandra Taddei, Enzo Picconi, Alessandro Pizza, Davide Celentano, Marco Piastra, Giancarlo Scoppettuolo, Giorgio Conti
INTRODUCTION: The aim of this study was to evaluate the effectiveness and safety of a new three-component 'bundle' for insertion and management of centrally inserted central catheters (CICCs), designed to minimize catheter-related bloodstream infections (CRBSIs) in critically ill children. METHODS: Our 'bundle' has three components: insertion, management, and education. Insertion and management recommendations include: skin antisepsis with 2% chlorhexidine; maximal barrier precautions; ultrasound-guided venipuncture; tunneling of the catheter when a long indwelling time is expected; glue on the exit site; sutureless securement; use of transparent dressing; chlorhexidine sponge dressing on the 7th day; neutral displacement needle-free connectors...
November 8, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29123003/outcomes-of-peritoneal-dialysis-catheter-left-in-place-after-kidney-transplantation
#3
Saúl Pampa-Saico, Fernando Caravaca-Fontán, Víctor Burguera-Vion, Víctor Diéz Nicolás, Estefanía Yerovi-León, Sara Jimenez-Álvaro, Ana Fernández-Rodríguez, Roberto Marcén, Maite Rivera-Gorrín
No clear consensus has been reached regarding the optimal time to remove the peritoneal dialysis catheter (PDC) after kidney transplantation (KT). This retrospective observational study, conducted in a single peritoneal dialysis (PD) unit including all PD patients who received a KT between 1995 - 2015, was undertaken to evaluate the clinical outcomes and potential complications associated with a PDC left in place after KT. Of the 132 PD patients who received a KT, 20 were excluded from the study. Of the remaining, 112 (85%) patients with functioning KT were discharged with their PDC left in place and had it removed in a mean interval of 5 ± 3 months after KT, after achieving optimal graft function...
November 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29122337/study-of-anatomical-variations-of-the-zygomaticofacial-foramen-and-calculation-of-reliable-reference-points-for-operation
#4
A Ferro, S Basyuni, C Brassett, V Santhanam
Dissection on to the facial aspect of the zygoma is common in procedures of the midface for trauma, craniofacial deformity, and cosmesis. These procedures carry the risk of injury to the neurovascular structures that exit from the zygomaticofacial foramen (ZFF). The purpose of this study was to map the ZFF, and to establish reliable reference points from which to identify it before and during operation. We also aimed to compare the anatomy of the ZFF between sexes and among geographical populations. A total of 429 adult skulls from nine geographical sites were used...
November 6, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29116395/correlations-between-sedimentation-sign-dural-sac-cross-sectional-area-and-clinical-symptoms-of-degenerative-lumbar-spinal-stenosis
#5
Sangbong Ko
PURPOSE: In this study, we addressed the correlation between the cross-sectional area (CSA) of the dural sac and the nerve root sedimentation sign (SedSign) and the correlation between the distance of claudication and the CSA of the dural sac or SedSign in patients with lumbar spinal stenosis. We also evaluated the reliability of clinical symptom prediction. METHODS: We checked claudication distance using a questionnaire, and we gauged low back pain when standing, referred pain, and radiating pain using visual analog scale scores...
November 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29110413/successful-heart-transplantation-in-patients-with-total-artificial-heart-infections
#6
Sarah Taimur, Timothy Sullivan, Mennakshi Rana, Gopi Patel, Julie Roldan, Kimberly Ashley, Sean Pinney, Anelechi Anyanwu, Shirish Huprikar
BACKGROUND: Data are limited on clinical outcomes in patients awaiting heart transplant (HT) with total artificial heart (TAH) infections (TAHIs). METHODS: We retrospectively reviewed all TAH recipients at our center. TAHI was classified as definite if a microorganism was isolated in cultures from the exit site or deep tissues around the TAH, as probable in patients without surgical or microbiologic evidence of infection but no other explanation for persistent or recurrent bloodstream infection (BSI); or possible in patients with clinical suspicion and radiographic findings suggestive of TAHI, but without surgical intervention or microbiologic evidence...
November 7, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29106565/optimum-position-of-transthoracic-intracardiac-line-following-cardiac-surgery
#7
T K Susheel Kumar, Saradha Subramanian, James Benjamin Tansey, Mayte Figueroa, David Zurakowski, Jerry Allen, Samir Shah, Anna Brauninger, Lindsey Bird, Mohammed Ali, Christopher J Knott-Craig
OBJECTIVES: The transthoracic intracardiac line placed in the right atrium provides a convenient access to the central venous system following cardiac surgery. However, it is associated with risks such as migration and bleeding. We conducted a retrospective study to determine whether position of transthoracic line with respect to site of exit from the chest makes a difference in the rate of complications. METHODS: All infants receiving a transthoracic intracardiac line in the right atrium following cardiac surgery between June 2012 and December 2015 were part of the study...
July 4, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29105095/minimally-invasive-technique-for-coxofemoral-luxation-stabilisation-using-transarticular-toggle-system-a-cadaveric-study
#8
U Segal, J Shani, R Joseph
OBJECTIVE: To present a novel, semi-closed, surgical technique for coxofemoral luxation stabilisation using a transarticular toggle rod. STUDY DESIGN: Cadaveric study. MATERIALS AND METHODS: Craniodorsal luxation was generated by transecting the ligamentum teres in 12 coxofemoral joints and was then reduced using a closed technique. Anteversion and inclination angles were measured using fluoroscopic projections. An arthroscope was inserted through a bone tunnel drilled from the third trochanter through the femoral neck...
November 3, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29100052/structural-basis-for-polyproline-mediated-ribosome-stalling-and-rescue-by-the-translation-elongation-factor-ef-p
#9
Paul Huter, Stefan Arenz, Lars V Bock, Michael Graf, Jan Ole Frister, Andre Heuer, Lauri Peil, Agata L Starosta, Ingo Wohlgemuth, Frank Peske, Jiří Nováček, Otto Berninghausen, Helmut Grubmüller, Tanel Tenson, Roland Beckmann, Marina V Rodnina, Andrea C Vaiana, Daniel N Wilson
Ribosomes synthesizing proteins containing consecutive proline residues become stalled and require rescue via the action of uniquely modified translation elongation factors, EF-P in bacteria, or archaeal/eukaryotic a/eIF5A. To date, no structures exist of EF-P or eIF5A in complex with translating ribosomes stalled at polyproline stretches, and thus structural insight into how EF-P/eIF5A rescue these arrested ribosomes has been lacking. Here we present cryo-EM structures of ribosomes stalled on proline stretches, without and with modified EF-P...
November 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29095374/achieving-drug-and-alcohol-abstinence-among-recently-incarcerated-homeless-women-a-randomized-controlled-trial-comparing-dialectical-behavioral-therapy-case-management-with-a-health-promotion-program
#10
Adeline M Nyamathi, Sanghyuk S Shin, Jolene Smeltzer, Benissa E Salem, Kartik Yadav, Maria L Ekstrand, Susan F Turner, Mark Faucette
BACKGROUND: Homeless female ex-offenders (homeless female offenders) exiting jail and prison are at a critical juncture during reentry and transitioning into the community setting. OBJECTIVE: The purpose of the study was to compare the effect of a dialectical behavioral therapy-case management (DBT-CM) program with a health promotion (HP) program on achieving drug and alcohol abstinence among female parolees/probationers residing in the community. METHODS: We conducted a multicenter parallel randomized controlled trial with 130 female parolees/probationers (aged 19-64 years) residing in the community randomly assigned to either DBT-CM (n = 65) or HP (n = 65)...
November 2017: Nursing Research
https://www.readbyqxmd.com/read/29093437/coupling-fission-and-exit-of-rab6-vesicles-at-golgi-hotspots-through-kinesin-myosin-interactions
#11
Stéphanie Miserey-Lenkei, Hugo Bousquet, Olena Pylypenko, Sabine Bardin, Ariane Dimitrov, Gaëlle Bressanelli, Raja Bonifay, Vincent Fraisier, Catherine Guillou, Cécile Bougeret, Anne Houdusse, Arnaud Echard, Bruno Goud
The actin and microtubule cytoskeletons play important roles in Golgi structure and function, but how they are connected remain poorly known. In this study, we investigated whether RAB6 GTPase, a Golgi-associated RAB involved in the regulation of several transport steps at the Golgi level, and two of its effectors, Myosin IIA and KIF20A participate in the coupling between actin and microtubule cytoskeleton. We have previously shown that RAB6-Myosin IIA interaction is critical for the fission of RAB6-positive transport carriers from Golgi/TGN membranes...
November 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29093024/phosphorylation-of-multiple-sites-within-an-acidic-region-of-alcadein-%C3%AE-is-required-for-kinesin-1-association-and-golgi-exit-of-alcadein-%C3%AE-cargo
#12
Yuriko Sobu, Keiko Furukori, Kyoko Chiba, Angus C Nairn, Masataka Kinjo, Saori Hata, Toshiharu Suzuki
Alcadein α (Alcα) is a major cargo of kinesin-1 that is subjected to anterograde transport in neuronal axons. Two tryptophan- and aspartic acid-containing (WD) motifs located in its cytoplasmic domain directly bind the tetratricopeptide repeat (TPR) motifs of kinesin light chain (KLC), which activate kinesin-1 and recruit kinesin-1 to Alcα cargo. We found that phosphorylation of three serine residues in the acidic region located between the two WD motifs is required for interaction with KLC. Phosphorylation of these serine residues may alter the disordered structure of the acidic region to induce the direct association with KLC...
November 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29091964/interaction-between-the-flagellar-pocket-collar-and-the-hook-complex-via-a-novel-microtubule-binding-protein-in-trypanosoma-brucei
#13
Anna Albisetti, Célia Florimond, Nicolas Landrein, Keni Vidilaseris, Marie Eggenspieler, Johannes Lesigang, Gang Dong, Derrick Roy Robinson, Mélanie Bonhivers
Trypanosoma brucei belongs to a group of unicellular, flagellated parasites that are responsible for human African trypanosomiasis. An essential aspect of parasite pathogenicity is cytoskeleton remodelling, which occurs during the life cycle of the parasite and is accompanied by major changes in morphology and organelle positioning. The flagellum originates from the basal bodies and exits the cell body through the flagellar pocket (FP) but remains attached to the cell body via the flagellum attachment zone (FAZ)...
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29090661/patent-foramen-ovale-closure-with-gore-helex-or-cardioform-septal-occluder-vs-antiplatelet-therapy-for-reduction-of-recurrent-stroke-or-new-brain-infarct-in-patients-with-prior-cryptogenic-stroke-design-of-the-randomized-gore-reduce-clinical-study
#14
Scott E Kasner, Lars Thomassen, Lars Søndergaard, John F Rhodes, Coby C Larsen, Joth Jacobson
Rationale The utility of patent foramen ovale (PFO) closure for secondary prevention in patients with prior cryptogenic stroke is uncertain despite multiple randomized trials completed to date. Aims The Gore REDUCE Clinical Study (REDUCE) aims to establish superiority of patent foramen ovale closure in conjunction with antiplatelet therapy over antiplatelet therapy alone in reducing the risk of recurrent clinical ischemic stroke or new silent brain infarct in patients who have had a cryptogenic stroke. Methods and design This controlled, open-label trial randomized 664 subjects with cryptogenic stroke at 63 multinational sites in a 2:1 ratio to either antiplatelet therapy plus patent foramen ovale closure (with GORE® HELEX® Septal Occluder or GORE® CARDIOFORM Septal Occluder) or antiplatelet therapy alone...
December 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29090277/temperature-and-osmotic-stress-dependence-of-the-thermodynamics-for-binding-linker-histone-h1-0-its-carboxyl-domain-h1-0-c-or-globular-domain-h1-0-g-to-b-dna
#15
V R Machha, C G Mikek, S Wellman, E A Lewis
Linker histones (H1) are the basic proteins in higher eukaryotes that are responsible for the final condensation of chromatin. In contrast to the nucleosome core histone proteins, the role of H1 in compacting DNA is not clearly understood. In this study ITC was used to measure the binding constant, enthalpy change, and binding site size for the interactions of H1(0), or its C-terminal (H1(0)-C) and globular (H1(0)-G) domains to highly polymerized calf-thymus DNA at temperatures from 288 K to 308 K. Heat capacity changes, ΔCp, for these same H1(0) binding interactions were estimated from the temperature dependence of the enthalpy changes...
December 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29084198/distinct-kinetics-of-serine-and-threonine-dephosphorylation-are-essential-for-mitosis
#16
Jamin B Hein, Emil P T Hertz, Dimitriya H Garvanska, Thomas Kruse, Jakob Nilsson
Protein phosphatase 2A (PP2A) in complex with B55 regulatory subunits reverses cyclin-dependent kinase 1 (Cdk1) phosphorylations at mitotic exit. Interestingly, threonine and serine residues phosphorylated by Cdk1 display distinct phosphorylation dynamics, but the biological significance remains unexplored. Here we demonstrate that the phosphothreonine preference of PP2A-B55 provides an essential regulatory element of mitotic exit. To allow rapid activation of the anaphase-promoting complex/cyclosome (APC/C) co-activator Cdc20, inhibitory phosphorylation sites are conserved as threonines while serine substitutions delay dephosphorylation and Cdc20 activation...
October 30, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/29074312/understanding-the-patient-experience-with-carcinoid-syndrome-exit-interviews-from-a-randomized-placebo-controlled-study-of-telotristat-ethyl
#17
Lowell Anthony, Claire Ervin, Pablo Lapuerta, Matthew H Kulke, Pamela Kunz, Emily Bergsland, Dieter Hörsch, David C Metz, Janice Pasieka, Nick Pavlakis, Marianne Pavel, Martyn Caplin, Kjell Öberg, John Ramage, Emily Evans, Qi Melissa Yang, Shanna Jackson, Karie Arnold, Linda Law, Dana B DiBenedetti
PURPOSE: Telotristat ethyl, an oral tryptophan hydroxylase inhibitor, is intended to treat carcinoid syndrome by reducing serotonin production. Telotristat ethyl was evaluated in TELESTAR, a Phase III study for patients who had carcinoid syndrome with at least 4 bowel movements (BMs) per day and who were receiving somatostatin analogue therapy. This interview substudy was conducted to provide insight into the patient experience in TELESTAR and to help understand whether reductions in BM frequency (the primary end point) and other symptoms were clinically meaningful...
October 23, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29065867/the-relative-risk-of-second-primary-cancers-in-austria-s-western-states-a-retrospective-cohort-study
#18
Oliver Preyer, Nicole Concin, Andreas Obermair, Hans Concin, Hanno Ulmer, Willi Oberaigner
BACKGROUND: Cancer survivors are at risk of developing a second primary cancer (SPC) later in life because of persisting effects of genetic and behavioural risk factors, the long-term sequelae of chemotherapy, radiotherapy and the passage of time. This is the first study with Austrian data on an array of entities, estimating the risk of SPCs in a population-based study by calculating standardized incidence ratios (SIRs). METHODS: This retrospective cohort study included all invasive incident cancer cases diagnosed within the years 1988 to 2005 being registered in the Tyrol and Vorarlberg Cancer Registries...
October 24, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29055293/the-diffusion-of-a-ga-atom-on-gaas-001-%C3%AE-2-2-%C3%A3-4-local-superbasin-kinetic-monte-carlo
#19
Yangzheng Lin, Kristen A Fichthorn
We use first-principles density-functional theory to characterize the binding sites and diffusion mechanisms for a Ga adatom on the GaAs(001)β2(2 × 4) surface. Diffusion in this system is a complex process involving eleven unique binding sites and sixteen different hops between neighboring binding sites. Among the binding sites, we can identify four different superbasins such that the motion between binding sites within a superbasin is much faster than hops exiting the superbasin. To describe diffusion, we use a recently developed local superbasin kinetic Monte Carlo (LSKMC) method, which accelerates a conventional kinetic Monte Carlo (KMC) simulation by describing the superbasins as absorbing Markov chains...
October 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29046348/d1-asn-298-in-photosystem-ii-is-involved-in-a-hydrogen-bond-network-near-the-redox-active-tyrosine-yz-for-proton-exit-during-water-oxidation
#20
Ryo Nagao, Hanayo Ueoka-Nakanishi, Takumi Noguchi
In photosynIn photosynthetic water oxidation, two water molecules are converted into one oxygen molecule and four protons at the Mn4CaO5 cluster in photosystem II (PSII) via the S-state cycle. Efficient proton exit from the catalytic site to the lumen is essential for this process. However, the exit pathways of individual protons through the PSII proteins remain to be identified. In this study, we examined the involvement of a hydrogen-bond network near the redox-active tyrosine YZ in proton transfer during the S-state cycle...
October 18, 2017: Journal of Biological Chemistry
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