keyword
MENU ▼
Read by QxMD icon Read
search

Exit site

keyword
https://www.readbyqxmd.com/read/28815213/identification-of-rab18-as-an-essential-host-factor-for-bk-polyomavirus-infection-using-a-whole-genome-rna-interference-screen
#1
Linbo Zhao, Michael J Imperiale
BK polyomavirus (BKPyV) is a human pathogen first isolated in 1971. BKPyV infection is ubiquitous in the human population, with over 80% of adults worldwide being seropositive for BKPyV. BKPyV infection is usually asymptomatic; however, BKPyV reactivation in immunosuppressed transplant patients causes two diseases, polyomavirus-associated nephropathy and hemorrhagic cystitis. To establish a successful infection in host cells, BKPyV must travel in retrograde transport vesicles to reach the nucleus. To make this happen, BKPyV requires the cooperation of host cell proteins...
July 2017: MSphere
https://www.readbyqxmd.com/read/28798498/non-parametric-regression-in-clustered-multistate-current-status-data-with-informative-cluster-size
#2
Ling Lan, Dipankar Bandyopadhyay, Somnath Datta
Datasets examining periodontal disease records current (disease) status information of tooth-sites, whose stochastic behavior can be attributed to a multistate system with state occupation determined at a single inspection time. In addition, the tooth-sites remain clustered within a subject, and the number of available tooth-sites may be representative of the true PD status of that subject, leading to an 'informative cluster size' scenario. To provide insulation against incorrect model assumptions, we propose a nonparametric regression framework to estimate state occupation probabilities at a given time and state exit/entry distributions, utilizing weighted monotonic regression and smoothing techniques...
January 2017: Statistica Neerlandica
https://www.readbyqxmd.com/read/28795380/peritoneal-dialysis-associated-catheter-infection-caused-by-mycobacterium-abscessus-in-an-elderly-patient-who-was-successfully-treated-with-catheter-removal
#3
Arata Hibi, Takahisa Kasugai, Keisuke Kamiya, Keisuke Kamiya, Chiharu Ito, Satoru Kominato, Ken Mizuguchi, Toshiyuki Miura, Katsushi Koyama
An 89-year-old Japanese man on peritoneal dialysis (PD) was suspected of having a PD-associated catheter infection. He visited the hospital because of the discharge of pus from the exit site of his catheter. Gram staining of the pus showed Gram-positive bacilli, but these were acid-fast bacilli. The rapidly growing nontuberculous mycobacteria, Mycobacterium abscessus, was isolated. PD catheter removal and debridement were immediately performed. The patient received combination antibiotic therapy. His clinical course was good, but he required hemodialysis due to the discontinuation of PD...
August 9, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28794295/foreign-body-reaction-to-dialysis-chatheter-and-peritoneal-fluid-eosinophilia-in-a-child-on-continuous-ambulatory-peritoneal-dialysis
#4
Nuran Cetin, Nadide Melike Sav, Evrim Ciftci, Bilal Yildiz
Foreign body reaction is a tissue response against implanted materials. We described for the first time the eosinophilic peritonitis and foreign body giant cell reaction to dialysis catheter in a nonatopic child on continuous ambulatory peritoneal dialysis. We found tenderness, redness, and swelling without purulent discharge around the peritoneal catheter; increased eosinophil count in cloudy dialysis fluid; and blood and hyperechoic granulomatous formation appearance surrounding the peritoneal catheter on ultrasonography and foreign body giant cell reaction to dialysis catheter in pathologic examination of granulomatous lesionin in our patient...
July 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28794039/the-ul21-tegument-protein-of-herpes-simplex-virus-type-1-is-differentially-required-for-the-syncytial-phenotype
#5
Akua Sarfo, Jason Starkey, Erica Mellinger, Dan Zhang, Pooja Chadha, Jillian Carmichael, John W Wills
The initial goal of this study was to re-examine the requirement of UL21 for herpes simplex virus 1 (HSV-1) replication. Previous studies suggested that UL21 is dispensable for replication in cell cultures, but a recent report on HSV-2 challenges those findings. As was done for the HSV-2 study, a UL21-null virus was made and propagated on complementing cells to discourage selection of compensating mutations. This HSV-1 mutant was able to replicate in non-complementing cells, even at a low MOI, though a reduction in titer was observed...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28790835/subcutaneous-gentamicin-injection-around-the-cuff-in-treatment-of-resistant-exit-site-infection-in-peritoneal-dialysis-patients-a-pilot-study
#6
Oguzhan Sıtkı Dizdar, Ozerhan Ozer, Selahattin Erdem, Ali Ihsan Gunal
BACKGROUND/PURPOSE: One of the most common complications of the peritoneal dialysis (PD) is the infection of the exit site of the peritoneal catheter. The aim of the present study was to evaluate the efficacy of the subcutaneous gentamicin injection around the cuff as a part of routine treatment of the resistant exit site infection (ESI). METHODS: If the exit site remains infected after a 2-week systemic antibiotics treatment, it is defined as resistant ESI. In these cases, systemic antibiotics were discontinued and a subcutaneous 40-mg gentamicin injection was administered around the external cuff of the PD catheter every 3 days...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28772071/systemic-delivery-of-folate-peg-sirna-lipopolyplexes-with-enhanced-intracellular-stability-for-in-vivo-gene-silencing-in-leukemia
#7
Dian-Jang Lee, Eva Kessel, Taavi Lehto, Xueying Liu, Naoto Yoshinaga, Kärt Padari, Ying-Chen Chen, Susanne Kempter, Satoshi Uchida, Joachim O Rädler, Margus Pooga, Ming-Thau Sheu, Kazunori Kataoka, Ernst Wagner
Protection of small interfering RNA (siRNA) against degradation and targeted delivery across the plasma and endosomal membranes to the final site of RNA interference are major aims for the development of siRNA therapeutics. Targeting for folate receptor (FR)-expressing tumors, we optimized siRNA polyplexes by co-formulating a folate-PEG-oligoaminoamide (for surface shielding and targeting) with one of three lipo-oligoaminoamides (optionally tyrosine-modified, for optimizing stability and size) to generate ~ 100 nm targeted lipopolyplexes (TLPs), which self-stabilize by cysteine disulfide crosslinks...
August 3, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28762670/radiological-tenckhoff-catheter-insertion-for-peritoneal-dialysis-a-cost-effective-approach
#8
James Lee, Nigel Mott, Usman Mahmood, John Clouston, Kara Summers, Pauline Nicholas, Pedro Henrique França Gois, Dwarakanathan Ranganathan
INTRODUCTION: Radiological insertion of Tenckhoff catheters can be an alternative option for peritoneal dialysis access creation, as compared to surgical catheter insertion. This study will review the outcomes and complications of radiological Tenckhoff catheter insertion in a metropolitan renal service and compare costs between surgical and radiological insertion. METHODS: Data were collected prospectively for all patients who had a Tenckhoff catheter insertion for peritoneal dialysis (PD) under radiological guidance at our hospital from May 2014 to November 2016...
August 1, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28760687/evaluation-of-transporters-in-drug-development-current-status-and-contemporary-issues
#9
REVIEW
Sue-Chih Lee, Vikram Arya, Xinning Yang, Donna A Volpe, Lei Zhang
Transporters govern the access of molecules to cells or their exit from cells, thereby controlling the overall distribution of drugs to their intracellular site of action. Clinically relevant drug-drug interactions mediated by transporters are of increasing interest in drug development. Drug transporters, acting alone or in concert with drug metabolizing enzymes, can play an important role in modulating drug absorption, distribution, metabolism and excretion, thus affecting the pharmacokinetics and/or pharmacodynamics of a drug...
July 28, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28754694/remodeling-of-er-exit-sites-initiates-a-membrane-supply-pathway-for-autophagosome-biogenesis
#10
Liang Ge, Min Zhang, Samuel J Kenny, Dawei Liu, Miharu Maeda, Kota Saito, Anandita Mathur, Ke Xu, Randy Schekman
Autophagosomes are double-membrane vesicles generated during autophagy. Biogenesis of the autophagosome requires membrane acquisition from intracellular compartments, the mechanisms of which are unclear. We previously found that a relocation of COPII machinery to the ER-Golgi intermediate compartment (ERGIC) generates ERGIC-derived COPII vesicles which serve as a membrane precursor for the lipidation of LC3, a key membrane component of the autophagosome. Here we employed super-resolution microscopy to show that starvation induces the enlargement of ER-exit sites (ERES) positive for the COPII activator, SEC12, and the remodeled ERES patches along the ERGIC A SEC12 binding protein, CTAGE5, is required for the enlargement of ERES, SEC12 relocation to the ERGIC, and modulates autophagosome biogenesis...
July 28, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28747464/lethal-digenic-mutations-in-the-k-channels-kir4-1-kcnj10-and-slack-kcnt1-associated-with-severe-disabling-seizures-and-neurodevelopmental-delay
#11
Sonia Majed Hasan, Ameera Balobaid, Alessandro Grottesi, Omar Dabbagh, Marta Cenciarini, Rifaat Rawashdeh, Afaf Al-Sagheir, Cecilia Bove, Lara Macchioni, Mauro Pessia, Mohammed Al-Owain, Maria Cristina D'Adamo
A 2-year-old boy presented profound developmental delay, failure to thrive, ataxia, hypotonia and tonic-clonic seizures that caused the death of the patient. Targeted and whole-exome sequencing revealed two heterozygous missense variants: a novel mutation in KCNJ10 gene that encodes for the inwardly-rectifying K(+) channel Kir4.1 and another previously characterized mutation in KCNT1 that encodes for the Na(+)-activated K(+) channel known as Slo2.2 or SLACK. The objectives of this study were to perform the clinical and genetic characterization of the proband and his family and to examine the functional consequence of the Kir4...
July 26, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28747320/microscopic-analysis-of-reconstituted-copii-coat-polymerization-and-sec16-dynamics
#12
Hirohiko Iwasaki, Tomohiro Yorimitsu, Ken Sato
COPII coat and the small GTPase Sar1 mediate protein export from the endoplasmic reticulum (ER) via specialized domains known as the ER exit sites. The peripheral ER protein Sec16 has been proposed to organize ER exit sites. However, it remains unclear how these molecules drive COPII coat polymerization. Here, we characterized the spatiotemporal relationships between the COPII components during their polymerization using fluorescence microscopy combined with an artificial planar membrane. We demonstrated that Sar1 dissociates from the membrane shortly after the COPII coat recruitment, and Sar1 is then no longer required for the COPII coat to bind to the membrane...
July 26, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28747291/dental-blogs-podcasts-and-associated-social-media-descriptive-mapping-and-analysis
#13
Julia Melkers, Diana Hicks, Simone Rosenblum, Kimberley R Isett, Jacqueline Elliott
BACKGROUND: Studies of social media in both medicine and dentistry have largely focused on the value of social media for marketing to and communicating with patients and for clinical education. There is limited evidence of how dental clinicians contribute to and use social media to disseminate and access information relevant to clinical care. OBJECTIVE: The purpose of this study was to inventory and assess the entry, growth, sources, and content of clinically relevant social media in dentistry...
July 26, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28746877/phospho-rasputin-stabilization-by-sec16-is-required-for-stress-granule-formation-upon-amino-acid-starvation
#14
Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S Sinsimer, Elizabeth R Gavis, Christian Behrends, Catherine Rabouille
Most cellular stresses induce protein translation inhibition and stress granule formation. Here, using Drosophila S2 cells, we investigate the role of G3BP/Rasputin in this process. In contrast to arsenite treatment, where dephosphorylated Ser142 Rasputin is recruited to stress granules, we find that, upon amino acid starvation, only the phosphorylated Ser142 form is recruited. Furthermore, we identify Sec16, a component of the endoplasmic reticulum exit site, as a Rasputin interactor and stabilizer. Sec16 depletion results in Rasputin degradation and inhibition of stress granule formation...
July 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28734185/primary-small-cell-neuroendocrine-carcinoma-of-the-breast-a-case-report-and-review-of-the-literature
#15
Abigail Tremelling, Selyne Samuel, Mary Murray
INTRODUCTION: Primary small cell neuroendocrine carcinoma of the breast (SCNCB) is a very uncommon type of breast cancer. Histology and morphology are virtually indistinguishable from small cell neuroendocrine carcinomas of the lung (SCNCL), mandating a search for a primary site elsewhere in the body. There is no standard approach to treatment as there are only a limited number of cases reported in the literature. This report summarizes a case of primary SCNCB and presents a review of the literature...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28733771/a-national-study-of-veterans-treatment-court-participants-who-benefits-and-who-recidivates
#16
Jack Tsai, Andrea Finlay, Bessie Flatley, Wesley J Kasprow, Sean Clark
Although there are now over 400 veterans treatment courts (VTCs) in the country, there have been few studies on participant outcomes in functional domains. Using national data on 7931 veterans in the Veterans Affairs (VA) Veterans Justice Outreach program across 115 VA sites who entered a VTC from 2011 to 2015, we examined the housing, employment, income, and criminal justice outcomes of VTC participants; and identified veteran characteristics predictive of outcomes. VTC participants spent an average of nearly a year in the program and 14% experienced a new incarceration...
July 21, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/28727709/transforaminal-percutaneous-endoscopic-discectomy-and-foraminoplasty-after-lumbar-spinal-fusion-surgery
#17
Jian-Jun Wu, Hui-Zhen Chen, Changkun Zheng
BACKGROUND: The most common causes of pain following lumbar spinal fusions are residual herniation, or foraminal fibrosis and foraminal stenosis that is ignored, untreated, or undertreated. The original surgeon may advise his patient that nothing more can be done in his opinion that the nerve was visually decompressed by the original surgery. Post-operative imaging or electrophysiological assessment may be inadequate to explain all the reasons for residual or recurrent symptoms. Treatment of failed lumbar spinal fusions by repeat traditional open revision surgery usually incorporates more extensive decompression causing increased instability and back pain...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727280/two-novel-effectors-of-trafficking-and-maturation-of-the-yeast-plasma-membrane-h-atpase
#18
Yosef Geva, Jonathan Crissman, Eric C Arakel, Natalia Gómez-Navarro, Silvia G Chuartzman, Kyle R Stahmer, Blanche Schwappach, Elizabeth A Miller, Maya Schuldiner
The endoplasmic reticulum (ER) is the entry site of proteins into the endomembrane system. Proteins exit the ER via COPII vesicles in a selective manner, mediated either by direct interaction with the COPII coat or aided by cargo receptors. Despite the fundamental role of such receptors in protein sorting, only a few have been identified. To further define the machinery that packages secretory cargo and targets proteins from the ER to Golgi membranes, we used multiple systematic approaches, which revealed two uncharacterized proteins that mediate the trafficking and maturation of Pma1, the essential yeast plasma membrane proton ATPase...
July 20, 2017: Traffic
https://www.readbyqxmd.com/read/28724148/integrative-medicine-in-residency-feasibility-and-effectiveness-of-an-online-program
#19
Patricia Lebensohn, Benjamin Kligler, Audrey J Brooks, Raymond Teets, Michele Birch, Paula Cook, Victoria Maizes
BACKGROUND AND OBJECTIVES: Online curricular interventions in residency have been proposed to address challenges of time, cost, and curriculum consistency. This study is designed to determine the feasibility and effectiveness of a longitudinal, multisite online curriculum in integrative medicine (IMR) for residents. METHODS: Residents from eight family medicine programs undertook the 200-hour online IMR curriculum. Their medical knowledge (MK) scores at completion were compared to a control group from four similar residency programs...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28721206/a-bipedal-mammalian-model-for-spinal-cord-injury-research-the-tammar-wallaby
#20
Norman R Saunders, Katarzyna M Dziegielewska, Sophie C Whish, Lyn A Hinds, Benjamin J Wheaton, Yifan Huang, Steve Henry, Mark D Habgood
Background: Most animal studies of spinal cord injury are conducted in quadrupeds, usually rodents. It is unclear to what extent functional results from such studies can be translated to bipedal species such as humans because bipedal and quadrupedal locomotion involve very different patterns of spinal control of muscle coordination. Bipedalism requires upright trunk stability and coordinated postural muscle control; it has been suggested that peripheral sensory input is less important in humans than quadrupeds for recovery of locomotion following spinal injury...
2017: F1000Research
keyword
keyword
24646
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"