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JOURNAL ARTICLE
Hao Liu, Michael Sacks, Natalie T Simonian, Joseph Gorman, Robert Gorman
Development of patient specific models of LV-MV interactions in ischemic mitral regurgitation (IMR) are complicated by the substantial variability and complex etiologies, making it difficult to extract underlying mechanisms. We thus developed a detailed ovine LV-MV finite element model based for the normal and acute post-MI states. The ovine LV FEM model was first extended to incorporate a detailed MV leaflet sub-model with a functionally-equivalent CT structure. The resulting complete LV-MV model was first used to simulate the full cardiac cycle in the normal state to establish baseline responses...
April 23, 2024: Journal of Biomechanical Engineering
#2
Moiz Saeed, Rand Sabanci, Adolfo Martinez, Andrew G Kim, Rohan M Prasad, Christopher Hanson, Michael Kehdi
Left ventricular aneurysms (LVAs) represent a rare yet critical complication arising from late-presenting myocardial infarction (MI). Here, we present the case of an 88-year-old male with chest pressure, elevated troponin, B-type natriuretic peptide, and lactate. The electrocardiogram showed sinus tachycardia and an old right bundle branch block. The patient was started on heparin infusion, but progressively worsening hypotension necessitated transfer to the intensive care unit and the initiation of vasopressors...
March 2024: Curēus
#3
JOURNAL ARTICLE
Min Hu, Xin Zhang, Can Hu, Zhen-Guo Ma, Sha-Sha Wang, Teng Teng, Xiao-Feng Zeng, Qi-Zhu Tang
AIMS: Ischemia/reperfusion (I/R) injury is an important complication of reperfusion therapy for acute myocardial infarction, extremely compromising the cardiac benefits of revascularization, however, specific and efficient treatment for cardiac I/R injury is still lacking. Isthmin-1 (ISM1) is a novel adipokine, and plays indispensable roles in regulating glycolipid metabolism and cell survival. The present study aims to investigate the potential role and molecular mechanism of ISM1 in cardiac I/R injury using gain- and loss-of-function approaches...
April 18, 2024: Cardiovascular Research
#4
Sul Gi Choi, Ji Seok Oh, Hoon Myoung, Mi Hyun Seo
Concomitant chemoradiotherapy (CCRT) treated patients experience various complications. We present a rare case of post-CCRT Bell's palsy and describe its various possible causes, so as to increase awareness among clinicians about Bell's palsy being a CCRT-associated adverse effect. The patient was a 48-year-old man diagnosed with squamous cell carcinoma who presented with post-CCRT Bell's palsy. After radiotherapy for 6 weeks (overall 67.5 Gy) and four rounds of cisplatin chemotherapy, he complained of paralysis of the entire left face...
April 2024: Journal of Dental Anesthesia and Pain Medicine
#5
JOURNAL ARTICLE
Chuanlin Zhang, Xueqin Wang, Jie Mi, Zeju Zhang, Xinyi Luo, Ruiying Gan, Shaoyu Mu
OBJECTIVE: Intensive care unit (ICU)-acquired weakness often occurs in patients with invasive mechanical ventilation (IMV). Early active mobility may reduce ICU-acquired weakness, improve functional status, and reduce disability. The aim of this study was to investigate whether high-intensity early mobility improves post-ICU discharge functional status of IMV patients. METHODS: 132 adult patients in the ICU who were undergoing IMV were randomly assigned into two groups with a ratio of 1 : 1, with one group received high-intensity early mobility (intervention group, IG), while the other group received conventional treatment (control group, CG)...
2024: Critical Care Research and Practice
#6
JOURNAL ARTICLE
Dennis D Kumi, Rohan Gajjar, Joshua T Narh, Edwin Gwira-Tamattey, Muhammad Sana, Nana Yaa Ampaw, Anna Oduro, Samuel M Odoi, Sheriff Dodoo, Setri Fugar
Background The impact of long-term systemic steroid use on electrical and mechanical complications following ST-segment elevation myocardial infarction (STEMI) has not been extensively studied. Methods In a retrospective cohort study of the National Inpatient Sample (NIS) from 2018 to 2020, adults admitted with STEMI were dichotomized based on the presence of long-term (current) systemic steroid (LTCSS) use. The primary outcome was all-cause mortality. Secondary outcomes included a composite of mechanical complications, electrical, hemodynamic, and thrombotic complications, as well as revascularization complexity, length of stay (LOS), and total charge...
February 2024: Curēus
#7
JOURNAL ARTICLE
Ken Nakamura, Shusuke Arai, Kimihiro Kobayashi, Shingo Nakai, Ri Sho, Ai Ishizawa, Daisuke Watanabe, Shuto Hirooka, Eiichi Ohba, Masahiro Mizumoto, Yoshinori Kuroda, Cholsu Kim, Hideaki Uchino, Takao Shimanuki, Tetsuro Uchida
OBJECTIVE: In patients with stable hemodynamic status after an acute coronary syndrome (ACS), coronary artery bypass grafting (CABG) after preoperative investigations can provide outcomes comparable to those of emergency surgery. However, no established guidelines exist regarding the preparation period before surgery. We report the results of the use of an inpatient cardiac rehabilitation program followed by CABG after an ACS to improve post-operative outcomes and prognosis after discharge...
March 4, 2024: BMC Cardiovascular Disorders
#8
Kazuhiro Ueno, Jota Nakano, Shingo Hirao, Tatsuhiko Komiya
INTRODUCTION: Post-myocardial infarction ventricular septal defect (PIVSD) is a life-threatening mechanical complication of acute myocardial infarction (AMI). Delayed elective surgical repair can be considered in patients who respond well to aggressive heart failure therapy. Impella has been reported as a bridge to allow the deferment of surgery for PIVSD. PRESENTATION OF CASE: This report describes our case of a 62-year-old male with PIVSD and cardiogenic shock...
February 17, 2024: International Journal of Surgery Case Reports
#9
JOURNAL ARTICLE
Roberto Scarsini, Rafail A Kotronias, Francesco Della Mora, Leonardo Portolan, Stefano Andreaggi, Stefano Benenati, Federico Marin, Sara Sgreva, Alberto Comuzzi, Caterina Butturini, Gabriele Pesarini, Domenico Tavella, Keith M Channon, Hector M Garcia Garcia, Flavio Ribichini, Adrian P Banning, Giovanni Luigi De Maria
BACKGROUND: Patients with ST-segment-elevation myocardial infarction but no coronary microvascular injury are at low risk of early cardiovascular complications (ECC). We aim to assess whether nonhyperemic angiography-derived index of microcirculatory resistance (NH-IMRangio ) could be a user-friendly tool to identify patients at low risk of ECC, potentially candidates for expedited care pathway and early hospital discharge. METHODS: Retrospective analysis of 2 independent, international, prospective, observational cohorts included 568 patients with ST-segment-elevation myocardial infarction...
March 2024: Circulation. Cardiovascular Interventions
#10
JOURNAL ARTICLE
Jeongmin Shin, Hyun Mi Kang, Sae Yun Kim, Young-Ah Youn, Chang Won Choi, Yun Sil Chang
Blood culture proven sepsis is associated with increased mortality and morbidity. Given the extended hospitalization of very preterm infants, catheter-related blood stream infections (CRBSIs) play a substantial role in sepsis. The reported incidence of CRBSIs in neonates varies from 3.2 to 21.8 CRBSIs per 1000 catheter line days. Moreover, discrepancies in neonatal practices and potential neglect may lead to the unwarranted prolongation of central lines. This study aims to compare two distinct periods (Pre-QI vs...
February 15, 2024: Scientific Reports
#11
JOURNAL ARTICLE
Yunhui Lv, Kai Li, Shuo Wang, Xiaokang Wang, Guangxin Yue, Yangyang Zhang, Xin Lv, Ping Zhao, Shiping Wang, Qi Zhang, Qiuju Li, Jinyan Zhu, Jubo Li, Peng Peng, Yue Li, Jiafei Luo, Xue Zhang, Jianzhong Yang, Baojie Zhang, Xuemin Wang, Min Zhang, Chen Shen, Xin Wang, Miao Wang, Zhen Ye, Yongchun Cui
AIM: Patients with diabetes mellitus have poor prognosis after myocardial ischemic injury. However, the mechanism is unclear and there are no related therapies. We aimed to identify regulators of diabetic myocardial ischemic injury. METHODS AND RESULTS: Mass spectrometry-based, non-targeted metabolomic approach was used to profile coronary sinus blood from diabetic and non-diabetic Bama-mini pigs at 0.5-h post coronary artery ligation. Six metabolites had a |log2 (Fold Change)|> 1...
February 9, 2024: Cardiovascular Diabetology
#12
JOURNAL ARTICLE
Matteo Matteucci, Daniele Ronco, Mariusz Kowalewski, Giulio Massimi, Michele De Bonis, Francesco Formica, Federica Jiritano, Thierry Folliguet, Nikolaos Bonaros, Sandro Sponga, Piotr Suwalski, Andrea De Martino, Theodor Fischlein, Giovanni Troise, Guglielmo Actis Dato, Filiberto Giuseppe Serraino, Shabir Hussain Shah, Roberto Scrofani, Jurij Matija Kalisnik, Andrea Colli, Claudio Francesco Russo, Marco Ranucci, Matteo Pettinari, Adam Kowalowka, Matthias Thielmann, Bart Meyns, Fareed Khouqeer, Jean-Francois Obadia, Udo Boeken, Caterina Simon, Shiho Naito, Andrea Musazzi, Roberto Lorusso
BACKGROUND AND AIMS: Mechanical complications (MCs) are rare but potentially fatal sequelae of acute myocardial infarction (AMI). Surgery, though challenging, is considered the treatment of choice. The authors sought to study early and long-term results of patients undergoing surgical treatment for post-AMI MCs. METHODS: Patients undergone surgical treatment for post-infarction MCs between 2001 through 2019 in 27 centers worldwide were retrieved from the database of CAUTION study...
February 7, 2024: European Heart Journal. Quality of Care & Clinical Outcomes
#13
Bing-Jie Xue, Wen-Zheng Hu, Chong-You Lee, Qing Yang, Li-Xin Jia, Yuan Wang, Yue Huang, Bo-Kang Qiao, Jie Du
Ventricular septal rupture (VSR) is a catastrophic mechanical complication of acute myocardial infarction (AMI) that can result in acute heart failure. Delaying operative intervention frequently leads to cardiogenic shock and multi-organ failure. Here we report a case of massive anterior MI complicated with VSR that was discovered through cardiac Doppler ultrasound and suspected multiple organ hemorrhage. The patient showed signs of rapid cardiogenic shock and eventually died. The morphological changes of VSR and MI were identified during necropsy, and microscopic examinations of the heart, brain, and kidney revealed multiple organ hemorrhage...
February 15, 2024: Heliyon
#14
JOURNAL ARTICLE
Dan Haberman, Rodrigo Estévez-Loureiro, Andrew Czarnecki, Paolo Denti, Pedro Villablanca, Konstantinos Spargias, Doron Sudarsky, Leor Perl, Paul Fefer, Lisa Manevich, Giulia Masiero, Luis Nombela-Franco, Lion Poles, Berenice Caneiro-Queija, Nicolas Bowers, Davide Schiavi, Giuseppe Tarantini, Francesco Melillo, Michael Chrissoheris, Danny Dvir, Francesco Maisano, Maurizio Taramasso, Mony Shuvy
AIMS: Acute mitral regurgitation (MR) in the setting of myocardial infarction (MI) may be the result of papillary muscle rupture (PMR). This condition is associated with high morbidity and mortality. We aim to evaluate the feasibility of transcatheter edge-to-edge mitral valve repair (TEER) in this acute setting. METHODS AND RESULTS: We analysed data from the International Registry of MitraClip in Acute Mitral Regurgitation following acute Myocardial Infarction (IREMMI) of 30 centres in Europe, North America, and the middle east...
February 1, 2024: ESC Heart Failure
#15
JOURNAL ARTICLE
Hakim Lamine, Abdeljelil Farhati, Hela Bouzidi, Syrine Saidane, Ihsen Zairi, Khadija Mzoughi, Sondos Kraeim
INTRODUCTION: Post-infarction ventricular septal defect (PIVSD) is one of the most serious mechanical complications of acute myocardial infarction (AMI). Over the last decade, percutaneous closure is increasingly undertaken, with results similar to cardiac surgery. We present a case of ST-elevated anterior AMI, complicated by apical PIVSD successfully treated with transcatheter closure. CASE REPORT: An 83-year-old man was hospitalized for chest pain occurred 18 hours before, during the night time...
January 22, 2024: Annales de Cardiologie et D'angéiologie
#16
REVIEW
Adivitch Sripusanapan, Panat Yanpiset, Sirawit Sriwichaiin, Natthaphat Siri-Angkul, Siriporn C Chattipakorn, Nipon Chattipakorn
Myocardial infarction (MI) and its associated complications including ventricular arrhythmias and heart failure are responsible for a significant incidence of morbidity and mortality worldwide. The ensuing cardiomyocyte loss results in neurohormone-driven cardiac remodeling, which leads to chronic heart failure in MI survivors. Ivabradine is a heart rate modulation agent currently used in treatment of chronic heart failure with reduced ejection fraction. The canonical target of ivabradine is the hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in cardiac pacemaker cells...
January 17, 2024: Acta Physiologica
#17
JOURNAL ARTICLE
Marta Lorente-Ros, Subrat Das, Aaqib Malik, Francisco Jose Romeo, Jose S Aguilar-Gallardo, Maya Fakhoury, Amisha Patel
BACKGROUND: Chronic kidney disease (CKD) and end-stage renal disease (ESRD) have been associated with worse outcomes after transcatheter aortic valve replacement (TAVR). With TAVR indications extending to a wider range of patient populations, it is important to understand the current implications of chronic renal insufficiency on clinical outcomes. We aim to determine the impact of CKD and ESRD on in-hospital outcomes after TAVR. METHODS: We queried the National Inpatient Sample for TAVR performed between 2016 and 2020 using International Classification of Diseases-10th Revision codes...
January 3, 2024: BMC Cardiovascular Disorders
#18
JOURNAL ARTICLE
Daniel Willie-Permor, Marcos Real, Sina Zarrintan, Ann C Gaffey, Mahmoud B Malas
BACKGROUND: It is not uncommon for patients requiring vascular surgery, and in particular aortic surgery, to have increased requirements for blood transfusion. However, studies examining the effects of perioperative transfusion for thoracic endovascular aortic repair (TEVAR) are limited. Using large multicenter data, we aimed to study the impact of perioperative blood transfusion on 30-day mortality and complications after TEVAR. METHODS: A total of 9,263 patients who underwent TEVAR were included in this retrospective study from the multicenter Vascular Quality Initiative cohort spanning 2010-2022...
December 26, 2023: Annals of Vascular Surgery
#19
REVIEW
Mehdi Shadmand, Jacob Lautze, Ali Mehdirad Md
Takotsubo cardiomyopathy or stress cardiomyopathy (SCM), was first described in 1990 and initially, it was thought to be only associated with short-term complications and mortality with a benign long-term prognosis comparable to a healthy population. However recent investigations have proven otherwise and have shown SCM patients might have comparable long-term morbidity and mortality to ST-elevation myocardial infarction (STEMI) patients. Many emotional, or physical stressors can trigger SCM, and have been able to describe an interplay of neurohormonal and inflammatory mechanisms as the pathophysiology of this disease...
December 27, 2023: Heart Failure Reviews
#20
JOURNAL ARTICLE
Daniele Ronco, Matteo Matteucci, Justine Mafalda Ravaux, Mariusz Kowalewski, Giulio Massimi, Federica Torchio, Cinzia Trumello, Shiho Naito, Nikolaos Bonaros, Michele De Bonis, Dario Fina, Adam Kowalówka, Marek Deja, Federica Jiritano, Giuseppe Filiberto Serraino, Jurij Matija Kalisnik, Carlo De Vincentiis, Marco Ranucci, Theodor Fischlein, Claudio Francesco Russo, Massimiliano Carrozzini, Udo Boeken, Nikolaos Kalampokas, Michele Golino, Roberto De Ponti, Matteo Pozzi, Jean-François Obadia, Matthias Thielmann, Roberto Scrofani, Stefania Blasi, Giovanni Troise, Carlo Antona, Andrea De Martino, Giosuè Falcetta, Guglielmo Actis Dato, Paolo Severgnini, Andrea Musazzi, Roberto Lorusso
OBJECTIVES: Post-acute myocardial infarction mechanical complications (post-AMI MCs) represent rare but life-threatening conditions, including free-wall rupture, ventricular septal rupture and papillary muscle rupture. During the coronavirus disease-19 (COVID-19) pandemic, an overwhelming pressure on healthcare systems led to delayed and potentially suboptimal treatments for time-dependent conditions. As AMI-related hospitalizations decreased, limited information is available whether higher rates of post-AMI MCs and related deaths occurred in this setting...
December 5, 2023: Interdiscip Cardiovasc Thorac Surg
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