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https://www.readbyqxmd.com/read/28650098/disparities-in-eurotransplant-liver-transplantation-waitlist-outcome-between-patients-with-and-without-exceptional-meld
#1
Andreas Umgelter, Alexander Hapfelmeier, Wouter Kopp, Marieke van Rosmalen, Xavier Rogiers, Markus Guba
BACKGROUND: The sickest-first principle in donor-liver allocation can be implemented by allocating organs to cirrhotic patients with the highest Model of End-stage Liver Disease (MELD) scores. For patients with other risk factors, standard (SE) and non-standard exceptions (NSE) have been developed. We investigated whether this system of matched MELD scores achieves similar outcome on the liver transplant waiting-list for various diagnostic groups in Eurotransplant (ET) countries with MELD-based individual allocation (Belgium, The Netherlands and Germany)...
June 26, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28646389/photodynamic-therapy-controls-of-staphylococcus-aureus-intradermal-infection-in-mice
#2
Palloma Porto Almeida, Ítalo Sousa Pereira, Karine Bitencourt Rodrigues, Lorena Santos Leal, Andressa Souza Marques, Luciano Pereira Rosa, Francine Cristina da Silva, Robson Amaro Augusto da Silva
Infections caused by Staphylococcus aureus lead to skin infections, as well as soft tissues and bone infections. Given the communal resistance to antibiotics developed by strains of this bacterium, photodynamic therapy emerges as a promising alternative treatment to control and cure infections. Females of the Balb/C mice were infected with 10(8) CFU of methicillin-resistant S. aureus (MRSA) and divided into four distinct groups: P-L- (negative control group), P+L- (group exposed only to curcumin), P-L+ (group exposed only to LED incidence of 450 nm, 75 mW/cm(2), and 54 J/cm(2) for 10 min), and P+L+ (group exposed to curcumin followed by 10 min of LED irradiation) (n = 24)...
June 23, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28643420/impact-on-survival-of-warfarin-in-patients-with-pulmonary-arterial-hypertension-receiving-subcutaneous-treprostinil
#3
Mona Ascha, Xuan Zhou, Youlan Rao, Omar A Minai, Adriano R Tonelli
INTRODUCTION: Anticoagulation is a common treatment modality in patients with pulmonary arterial hypertension (PAH). Further studies are needed to appropriately assess the risk / benefit ratio of anticoagulation, particularly in PAH patients receiving PAH-specific therapies. AIMS: We use observational long-term data on PAH patients treated with subcutaneous (SQ) treprostinil from a large open-label study. Patients were followed for up to four years. The use of warfarin and bleeding events were recorded...
June 23, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28642910/influence-of-abutment-design-on-retention-of-metal-copings-cemented-to-implants
#4
Albano Porto da Cunha, Glauco Pereira Moysés, Ana Christina Claro Neves, Rafael Pino Vitti, Flávia Cardoso da Rosa Goulart, Laís Regiane da Siva-Concílio
Objective The study evaluated the influence of abutment design on the retention of implant-cemented metal copings. Material and methods Two abutments of the same system with the same indications, height and the total occlusal convergence, but of different designs were evaluated. Ten RN synOcta abutments (Straumann, Waltham, MA) and ten RN titanium solid abutments (Straumann, Waltham, MA) were tightened to 35 Ncm on 20 implant analogs previously placed in resin blocks. Twenty plastic burnout copings were waxed, included, cast and machined by a single operator...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28639220/emergence-of-rabbit-haemorrhagic-disease-virus-2-in-the-archipelago-of-madeira-portugal-2016-2017
#5
Carina Luísa Carvalho, Sara Silva, Paz Gouveia, Margarida Costa, Elsa Leclerc Duarte, Ana Margarida Henriques, Sílvia Santos Barros, Tiago Luís, Fernanda Ramos, Teresa Fagulha, Miguel Fevereiro, Margarida Dias Duarte
We report the detection of rabbit haemorrhagic disease virus 2 (RHDV2) in the Madeira archipelago, Portugal. Viral circulation was confirmed by RT-qPCR and vp60 sequencing. Epidemiological data revealed the outbreak initiated in October 2016 in Porto Santo affecting wild and domestic rabbits. It was then detected three months later on the island of Madeira. Five haplotypes were identified and a genetic overall similarity of 99.54 to 99.89% was observed between the two viral populations. Unique single nucleotide polymorphisms were recognised in the Madeira archipelago strains, two of which resulting in amino acid substitutions at positions 480 and 570 in the VP60 protein...
June 21, 2017: Virus Genes
https://www.readbyqxmd.com/read/28624933/influence-of-food-consumption-patterns-and-galician-lifestyle-on-human-gut-microbiota
#6
María Castro-Penalonga, Paula Roca-Saavedra, Jose Manuel Miranda, Jose Julio Porto-Arias, Carolina Nebot, Alejandra Cardelle-Cobas, Carlos Manuel Franco, Alberto Cepeda
The proportion of different microbial populations in the human gut is an important factor that in recent years has been linked to obesity and numerous metabolic diseases. Because there are many factors that can affect the composition of human gut microbiota, it is of interest to have information about what is the composition of the gut microbiota in different populations in order to better understand the possibilities for improving nutritional management. A group of 31 volunteers were selected according to established inclusion and exclusion criteria and were asked about their diet history, lifestyle patterns, and adherence to the Southern European Atlantic Diet...
June 17, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28623670/feasibility-and-safety-of-right-and-left-heart-catheterization-via-an-antecubital-fossa-vein-and-the-radial-artery-in-patients-with-heart-failure
#7
Domenico D'Amario, Francesco Burzotta, Antonio M Leone, Italo Porto, Giampaolo Niccoli, Cristina Aurigemma, Aureliano Ruggio, Josip A Borovac, Massimo Massetti, Carlo Trani, Filippo Crea
OBJECTIVES: Heart failure is the leading cause of hospitalization among patients older than 65 years of age. A significant proportion of patients require heart catheterization for diagnostic, therapeutic, and prognostic purposes. To determine the feasibility and safety of full arm-arm catheterization access, we aimed to compare this approach with other established catheterization approaches. METHODS AND RESULTS: In this retrospective cohort study, a total of 493 consecutive patients with heart failure requiring right and left heart catheterization were studied and analyzed...
June 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28611787/lack-of-diuretic-efficiency-but-not-low-diuresis-early-in-an-acutely-decompensated-heart-failure-episode-is-associated-with-increased-180-day-mortality
#8
João Pedro Ferreira, Nicolas Girerd, Pedro Bettencourt Medeiros, Miguel Bento Ricardo, Tiago Almeida, Alexandre Rola, Faiez Zannad, Patrick Rossignol, Irene Aragão
INTRODUCTION: The assessment of the amount of urine produced by the dose of administered diuretic has been proposed as the main signal of interest in diuretic responsiveness - diuretic efficiency (DE). The main aim of our study is to determine if a low DE is associated with 180-day all-cause mortality (ACM). METHODS: During a 3-year period, we retrospectively studied patients with acutely decompensated heart failure (ADHF) and respiratory insufficiency admitted to the emergency room of a tertiary university hospital in Porto, Portugal...
February 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28609270/a-prospective-study-comparing-two-embryo-transfer-soft-catheters
#9
Emily De Conto, Artur K Schuster, Vanessa K Genro, Rita Chapon, Daniela S da Silva, João Sabino Cunha-Filho
OBJECTIVES: To compare reproductive outcomes using two different soft catheters i.e. Set TDT® and Cook® Sydney IVF. The primary outcome was defined as a positive β-human chorionic gonadotropin (β-hCG) test. METHODS: Our prospective study recruited 68 patients undergoing in vitro fertilization cycles in a private fertility clinic in Porto Alegre, Brazil, between January 2014 and April 2016. They were divided into two groups according to the catheter that would be used for the embryo transfer, and the groups were matched by age...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28606322/peripheral-and-placental-immune-responses-in-goats-after-primoinfection-with-neospora-caninum-at-early-mid-and-late-gestation
#10
Wagnner José Nascimento Porto, Pilar Horcajo, Pomy de Cássia Peixoto Kim, Javier Regidor-Cerrillo, Elton Amorim Romão, Gema Álvarez-García, Emanuela Polimeni de Mesquita, Rinaldo Aparecido Mota, Luis Miguel Ortega-Mora
Neospora caninum can cause reproductive failure in goats. However, the pathogenesis of neosporosis in this domestic species remains largely unknown. We recently demonstrated that the outcome of experimental infection by N. caninum in pregnant goats is highly dependent on the time of gestation, during which infection occurs. In the present study, we examined the peripheral and placental immune responses in these groups of goats infected with 10(6) tachyzoites of the Nc-Spain7 isolate at early (G1, at day 40 of gestation, dg), mid (G2, 90 dg) and late (G3, 120 dg) gestation, together with a group of non-infected goats as a control group (G4)...
August 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28605483/vedolizumab-in-pediatric-inflammatory-bowel-disease-a-retrospective-multi-center-experience-from-the-paediatric-ibd-porto-group-of-espghan
#11
Oren Ledder, Amit Assa, Arie Levine, Johanna C Escher, Lissy de Ridder, Frank Ruemmele, Neil Shah, Ron Shaoul, Victorien M Wolters, Astor Rodrigues, Holm H Uhlig, Carsten Posovsky, Kaija-Leena Kolho, Christian Jakobsen, Shlomi Cohen, Dror S Shouval, Tim de Meij, Javier Martin-de-Carpi, Lisa Richmond, Jiri Bronsky, Mira Friedman, Dan Turner
Background: Vedolizumab, an anti-integrin antibody, has proven to be effective in adults with Inflammatory Bowel Disease (IBD), but the data in pediatrics are limited. We describe the short-term effectiveness and safety of vedolizumab in a European multi-center pediatric IBD cohort. Method: Retrospective review of children (2-18 years) treated with vedolizumab from 19 centers affiliated with the Paediatric IBD Porto group of ESPGHAN. Primary outcome was week 14 corticosteroid-free remission (CFR)...
June 9, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28597752/withdrawal-of-long-term-epoprostenol-therapy-in-pulmonary-arterial-hypertension-pah
#12
George Calcaianu, Mihaela Calcaianu, Matthieu Canuet, Irina Enache, Romain Kessler
Once initiated for pulmonary arterial hypertension (PAH), epoprostenol treatment usually needs to be delivered for an indefinite duration. It is possible that some participants could be transitioned from epoprostenol to oral therapies. We retrospectively evaluated eight PAH participants transitioned from epoprostenol to PAH oral drugs. The criteria for epoprostenol withdrawal were: (1) persistent improvement of clinic and hemodynamic status; (2) stable dose of epoprostenol for the last three months; and (3) the participant's preference for oral therapy after evaluation of risk-benefit...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28588751/protein-tolerance-to-standard-and-high-protein-meals-in-patients-with-liver-cirrhosis
#13
Octavio Campollo, Dirk Sprengers, Gitte Dam, Hendrik Vilstrup, Neil McIntyre
AIM: To investigate the plasma amino acid response and tolerance to normal or high protein meals in patients with cirrhosis. METHODS: The plasma amino acid response to a 20 g mixed protein meal was compared in 8 biopsy-proven compensated cirrhotic patients and 6 healthy subjects. In addition the response to a high protein meal (1 g/kg body weight) was studied in 6 decompensated biopsy-proven cirrhotics in order to evaluate their protein tolerance and the likelihood of developing hepatic encephalopathy (HE) following a porto-caval shunt procedure...
May 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28577050/anticonvulsive-activity-of-1s-verbenone-involving-rna-expression-of-bdnf-cox-2-and-c-fos
#14
Cynthia Germoglio Farias de Melo, Paula Regina Rodrigues Salgado, Diogo Vilar da Fonsêca, Renan Marinho Braga, Marcelo Ricardo Dutra Caldas Filho, Ingrid Eulália Vieira de Farias, Hilzeth de Luna Freire Pessôa, Eleonidas Moura Lima, Ian Porto Gurgel do Amaral, Damião Pergentino de Sousa, Reinaldo Nóbrega de Almeida
(1S)-(-)-verbenone (VRB) is a monoterpene present in the essential oils of many plants which has shown therapeutic effect; however, its anticonvulsant activity has not yet been evaluated. The present work sought to investigate the anticonvulsant activity of VRB using pilocarpine and pentylenetetrazole-induced seizure testing; seeking also probable mechanisms of action. VRB caused no significant changes in motor coordination. Also, no significant data was observed in the pilocarpine-induced seizure tests. In the PTZ-induced seizures test, VRB showed anticonvulsant activity at doses of 200 mg/kg i...
June 2, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28572055/estrogen-regulates-spatially-distinct-cardiac-mitochondrial-subpopulations
#15
Rogério Faustino Ribeiro Junior, Paula Lopes Rodrigues, Elis Aguiar Morra, Karoline Sousa Ronconi, Patrícia Ribeiro Do Val Lima, Marcella Leite Porto, Maylla Ronacher Simões, Dalton Valentim Vassallo, Suely Gomes Figueiredo, Ivanita Stefanon
Increased susceptibility to permeability transition pore (mPTP) is a significant concern to decreased cardiac performance in postmenopausal females. The goal of this study was to assess the effects of estrogen deficiency on the two spatially distinct mitochondrial subpopulations from left ventricle: subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria (IFM) based on: morphology, membrane potential, oxidative phosphorylation, mPTP and reactive oxygen species production. Female rats (8weeks old) that underwent bilateral ovariectomy were randomly assigned to receive daily treatment with placebo (OVX), estrogen replacement (OVX+E2) and Sham for 60days...
May 29, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28559699/pulmonary-hypertension-in-patients-with-hepatic-cirrhosis-and-portal-hypertension-an-echographic-study
#16
Adriana V Gurghean, Ioana A Tudor
AIM OF THE STUDY: The aim of the study is to determine the frequency of pulmonary hypertension in patients with hepatic cirrhosis and portal hypertension, to determine the possibility of an accurate ultrasound diagnosis of the characteristics of this complication. METHOD: 347 patients with liver cirrhosis consecutively hospitalized at Coltea Clinical Hospital were screened. 61 were excluded because of other possible causes of portal or pulmonary hypertension. All patients were investigated clinically and by abdominal and cardiac ultrasonography...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28559064/endoscopic-third-ventriculostomy-for-the-treatment-of-hydrocephalus-in-a-paediatric-population-with-myelomeningocele
#17
Joana Rei, Josué Pereira, Carina Reis, Sérgio Salvador, Rui Vaz
BACKGROUND: Hydrocephalus develops in up to 90% of patients born with myelomeningocele. Although Endoscopic Third Ventriculostomy (ETV) is currently considered the preferred treatment for obstructive hydrocephalus, its results have been inconsistent in patients with myelomeningocele. This study focuses on clinical and radiological outcomes of ETV in children with hydrocephalus related to myelomeningocele. METHODS: Medical records of 18 paediatric patients with myelomeningocele submitted to ETV from 1998 to 2015, at the Centro Hospitalar S...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28544631/spermatozoa-from-males-with-reduced-fecundity-exhibit-differential-dna-methylation-patterns
#18
M Laqqan, S Tierling, Y Alkhaled, C Lo Porto, E F Solomayer, M Hammadeh
Infertility affects 10-15% of couples, and approximately 50% of cases are linked to male factor infertility. The purpose of this study was to evaluate the DNA methylation patterns in spermatozoa from males who are suffering from a reduction in fecundity. Thirty samples were subjected to 450K arrays as a screening study to evaluate the variation in sperm DNA methylation levels between cases and controls groups, and then four CpG sites (cg05799088, cg07227024, cg16338278, and cg08408433) underwent to deep bisulfite sequencing to validate the observed methylation differences in 111 samples (56 proven fertile males as 'controls' and 55 males suffering from a reduction in fecundity as 'cases')...
May 23, 2017: Andrology
https://www.readbyqxmd.com/read/28538800/effect-of-aqueous-extract-of-the-leaves-of-baccharis-trimera-on-the-proliferation-of-hepatocytes-after-partial-hepatectomy-in-rats
#19
Sonia Oliveira Lima, Maria Bernadete Galrão de Almeida Figueiredo, Vanessa Rocha de Santana, Danillo Primo Andrade Santana, Matheus de Souza Nogueira, Erick Sobral Porto, Renata Lima Batalha de Andrade, Jessica Macêdo Santos, Ricardo Luiz Cavalcanti de Albuquerque, Juliana Cordeiro Cardoso
Purpose: To evaluate the effect of aqueous extract of Baccharis trimera leaves on the proliferative capacity of the liver after partial hepatectomy (PH) in rats. Methods: Twenty Wistar rats weighing between 300 and 450g were divided into two groups: control (HP) and test (HP100-rats that received the aqueous extract of Baccharis trimera for four days at a dose of 100 mg / kg / day). On the fifth day, animals from both groups underwent resection of 70% of the liver...
April 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28534139/pulmonary-emphysema-cross-linking-with-pulmonary-fibrosis-and-vice-versa-a-non-usual-experimental-intervention-with-elastase-and-bleomycin
#20
Isabella Cattani-Cavalieri, Adriane Graça Reis, Emanuel Kennedy-Feitosa, Vanessa Pinho-Ribeiro, Manuella Lanzetti, Lycia Brito Gitirana, Bruna Romana-Souza, Luis Cristóvão Porto, Samuel Santos Valença
Elastase (PPE) is usually used for emphysema models, whereas bleomycin (BLM) is used for fibrosis models. The aim of this study was to investigate the effect of BLM in PPE-induced emphysema, as well as the effect of PPE in BLM-induced fibrosis. C57BL/6 mice were divided into five groups: control, PPE, BLM, PPE + BLM, and BLM + PPE. Mice received saline, PPE (3 U/mouse), or BLM (20 U/kg) by intranasal instillation. Mice from the BLM and BLM + PPE groups received BLM on day 0 and saline or PPE on day 21, respectively...
May 23, 2017: Inflammation
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