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https://www.readbyqxmd.com/read/29024923/a-ghep-isfg-collaborative-study-on-the-genetic-variation-of-38-autosomal-indels-for-human-identification-in-different-continental-populations
#1
R Pereira, C Alves, M Aler, A Amorim, C Arévalo, E Betancor, D Braganholi, M L Bravo, P Brito, J J Builes, G Burgos, E F Carvalho, A Castillo, C I Catanesi, R M B Cicarelli, P Coufalova, P Dario, M E D'Amato, S Davison, J Ferragut, M Fondevila, S Furfuro, O García, A Gaviria, I Gomes, E González, A Gonzalez-Liñan, T E Gross, A Hernández, Q Huang, S Jiménez, L F Jobim, A M López-Parra, M Marino, S Marques, G Martínez-Cortés, V Masciovecchio, D Parra, G Penacino, M F Pinheiro, M J Porto, Y Posada, C Restrepo, T Ribeiro, L Rubio, A Sala, A Santurtún, L S Solís, L Souto, E Streitemberger, A Torres, C Vilela-Lamego, J J Yunis, I Yurrebaso, L Gusmão
A collaborative effort was carried out by the Spanish and Portuguese Speaking Working Group of the International Society for Forensic Genetics (GHEP-ISFG) to promote knowledge exchange between associate laboratories interested in the implementation of indel-based methodologies and build allele frequency databases of 38 indels for forensic applications. These databases include populations from different countries that are relevant for identification and kinship investigations undertaken by the participating laboratories...
September 22, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29019579/epidemiological-study-of-facial-fractures-at-the-oral-and-maxillofacial-surgery-service-santa-casa-de-misericordia-hospital-complex-porto-alegre-rs-brazil
#2
Rodrigo Andrighetti Zamboni, João Carlos Birnfeld Wagner, Maurício Roth Volkweis, Eduardo Luis Gerhardt, Elissa Muller Buchmann, Caren Serra Bavaresco
OBJECTIVES: to investigate the incidence and etiology of face trauma with diagnosis of facial fracture treated at the Buccomaxillofacial Surgery and Traumatology Service of the Santa Casa de Misericórdia Hospital Complex in Porto Alegre. METHODS: we conducted a cross-sectional, retrospective epidemiological study of 134 trauma victims with 153 facial fractures. RESULTS: the male gender was the most affected (86.6%) and the incidence was higher in the age group from 21 to 30 years...
September 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28988345/partial-caries-removal-in-deep-caries-lesions-a-5-year-multicenter-randomized-controlled-trial
#3
M Maltz, B Koppe, J J Jardim, L S Alves, L M de Paula, P M Yamaguti, J C F Almeida, M S Moura, H D Mestrinho
OBJECTIVE: This multicenter randomized controlled clinical trial aimed to compare the outcomes of stepwise excavation (SW) and partial caries removal (PCR) regarding the maintenance of pulp vitality in deep caries lesions over 5 years. METHODS: At baseline, 299 permanent molars with deep caries lesions were randomly assigned to control or test groups. The control group received the stepwise excavation treatment (SW), while the test group received partial caries removal from the pulpal wall followed by restoration in a single session (PCR)...
October 8, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28977232/humanization-in-the-intensive-care-perception-of-family-and-healthcare-professionals
#4
Flavia Feron Luiz, Rita Catalina Aquino Caregnato, Márcia Rosa da Costa
Objective: Understanding perceptions of family members and healthcare professionals about humanization at the Intensive Care Unit (ICU) to direct it to an educational action. Method: Exploratory descriptive and qualitative study conducted in an ICU level 3 of a public hospital in Porto Alegre, RS, Brazil, with fourteen subjects, eight family members and six healthcare professionals. Data collection carried out through semi-structured interviews and focus group. Content Analysis was used...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28977070/cardiovascular-risk-and-bipolar-disorder-factors-associated-with-a-positive-coronary-calcium-score-in-patients-with-bipolar-disorder-type-1
#5
Aline R Wageck, Felipe S Torres, Clarissa S Gama, Dayane S Martins, Ellen Scotton, Ramiro Reckziegel, Monise Costanzi, Regis G Rosa, Flávio Kapczinski, Maurício Kunz
OBJECTIVE: Cardiovascular disease is the leading cause of death in patients with bipolar disorder. The aim of this study was to evaluate the factors associated with positive coronary calcium score (CCS) in individuals with bipolar disorder type 1. METHODS: Patients from the Bipolar Disorder Program at Hospital de Clínicas de Porto Alegre, Brazil, underwent computed tomography scanning for calcium score measurement. Clinical and sociodemographic variables were compared between patients according to their CCS status: negative (CCS = 0) or positive (CCS > 0)...
October 2, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28969719/high-dose-enoxaparin-in-the-treatment-of-abdominal-angiostrongyliasis-in-swiss-mice
#6
A S S Sandri, R Rodriguez, M M Costa, S M Porto, D Schwingel, M I B Vieira
Abdominal angiostrongyliasis (AA) is caused by Angiostrongylus costaricensis, which inhabits mesenteric arteries. There is no drug treatment for AA, and since intestinal infarction due to thrombi is one of the main complications of the disease, the use of anticoagulants may be a treatment option. Thus, we aimed to assess the effect of high doses of enoxaparin on the prevention of ischaemic intestinal lesions and on the survival of mice infected with A. costaricensis. Twenty-four mice were infected with L3 of A...
October 3, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28969568/in-vitro-and-in-silico-activity-of-iridoids-against-leishmania-amazonensis
#7
Gilsane Lino von Poser, Maria Helena Vendruscolo, Gustavo Machado Neves, Luciano Porto Kagami, Luiz Carlos Rodrigues, Maria Luisa Diehl, Simone Cristina Baggio Gnoatto, Sérgio Augusto de Loreto Bordignon, Pedro Roosevelt Torres Romão, Vera Lucia Eifler Lima
BACKGROUND: Leishmaniasis reaches millions of people around the world. The control of the disease is difficult due to the restricted access to the diagnosis and medication and the low adherence to the treatment. Thus, more efficient drugs are need and natural products are good alternatives. Iridoids, natural products with reported leishmanicidal activity, can be exploited for the development of anti-Leishmania drugs. The aim of this study was to isolate and to investigate the in vitro activity of iridoids against Leishmania amazonensis and to compare the activity in silico of these compounds with those reported as active against this parasite...
October 2, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28965663/perceptual-auditory-and-acoustical-analysis-of-the-voices-of-transgender-women
#8
Karine Schwarz, Anna Martha Vaitses Fontanari, Angelo Brandelli Costa, Bianca Machado Borba Soll, Dhiordan Cardoso da Silva, Anna Paula de Sá Villas-Bôas, Carla Aparecida Cielo, Gabriele Rodrigues Bastilha, Vanessa Veis Ribeiro, Maria Elza Kazumi Yamaguti Dorfman, Maria Inês Rodrigues Lobato
Voice is an important gender marker in the transition process as a transgender individual accepts a new gender identity. The objectives of this study were to describe and relate aspects of a perceptual-auditory analysis and the fundamental frequency (F0) of male-to-female (MtF) transsexual individuals. A case-control study was carried out with individuals aged 19-52 years who attended the Gender Identity Program of the Hospital de Clínicas of Porto Alegre. Vocal recordings from the MtF transgender and cisgender individuals (vowel /a:/ and six phrases of Consensus Auditory Perceptual Evaluation Voice [CAPE-V]) were edited and randomly coded before storage in a Dropbox folder...
September 28, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28954142/rape-and-pregnancy-of-girls-aged-up-to-13-years-in-brazil-characteristics-and-implications-in-health-during-gestation-delivery-and-childbirth
#9
Rayone Moreira Costa Veloso Souto, Denise Lopes Porto, Isabella Vitral Pinto, Carlos Cezar Flores Vidotti, Laura Augusta Barufaldi, Mariana Gonçalves de Freitas, Marta Maria Alves da Silva, Cheila Marina de Lima
Sexual violence against children and adolescents is a serious threat to the rights and full health of this age group. This study aims to describe the characteristics of mothers aged up to 13, and analyze the profile of cases of notified rape in this age range and repercussions of this violence during pregnancy and childbirth. It is a comparative study of the characteristics of gestation and childbirth of girls aged up to 13 who have had children, without or with notification of rape, in the Violence & Accidents Vigilance (VIVA) System of the Brazilian Case Registry Database (Sistema de Informação de Agravos de Notificação - SINAN)...
September 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28954056/evolution-of-tobacco-use-indicators-according-to-telephone-surveys-2006-2014
#10
Deborah Carvalho Malta, Sheila Rizzato Stopa, Maria Aline Siqueira Santos, Silvânia Suely Caribé de Araújo Andrade, Tais Porto Oliveira, Elier Broche Cristo, Marta Maria Alves da Silva
The goal of this study was to describe the trend of tobacco-use indicators for adults in Brazilian state capitals. Simple linear regression was used to analyze tobacco-use trends according to data from telephone survey VIGITEL between 2006 and 2014. The prevalence of smokers in Brazil dropped 0.645p.p. per year this period, from 15.6% (2006) to 10.8% (2014). There was a decrease per sex, schooling, major regions, and in most age groups. The prevalence of former smokers dropped from 22.2% (2006) to 21.2% (2014); smoking 20 cigarettes or more per day went from 4...
September 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28951582/expert-consensus-document-advances-in-the-physiological-assessment-and-diagnosis-of-gerd
#11
REVIEW
Edoardo Savarino, Albert J Bredenoord, Mark Fox, John E Pandolfino, Sabine Roman, C Prakash Gyawali
GERD is a common condition worldwide. Key mechanisms of disease include abnormal oesophagogastric junction structure and function, and impaired oesophageal clearance. A therapeutic trial of acid-suppressive PPI therapy is often the initial management, with endoscopy performed in the setting of alarm symptoms and to exclude other conditions. If symptoms persist and endoscopy does not reveal evidence of GERD, oesophageal function tests are performed, including oesophageal manometry and ambulatory reflux monitoring...
September 27, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28891938/time-course-of-the-phenotype-of-blood-and-bone-marrow-monocytes-and-macrophages-in-the-lung-after-cigarette-smoke-exposure-in-vivo
#12
Camila Oliveira da Silva, Andréa Monte-Alto-Costa, Mariana Renovato-Martins, Filipe Jorge Viana Nascimento, Samuel Dos Santos Valença, Vincent Lagente, Luís Cristóvão Pôrto, Tatiana Victoni
Alveolar macrophages play a central role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Monocytes are recruited from blood during inflammation and then mature into alveolar macrophages. The aim of this study was to investigate the effect of cigarette smoke (CS) at different times in lung macrophages and monocytes from blood and bone marrow in mice. Male mice (C57BL/6, n = 45) were divided into groups: control, CS 5 days, CS 14 days and CS 30 days. Five days' CS exposure induced a pronounced influx of neutrophils and macrophages in the lung associated with increased levels of keratinocyte chemoattractant (KC), tumor necrosis factor-α (TNF-α), nitric oxide (NO) and matrix metalloproteinase (MMP)-12...
September 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28886998/propolis-reversed-cigarette-smoke-induced-emphysema-through-macrophage-alternative-activation-independent-of-nrf2
#13
Marina Valente Barroso, Isabella Cattani-Cavalieri, Lycia de Brito-Gitirana, Alain Fautrel, Vincent Lagente, Martina Schmidt, Luís Cristóvão Porto, Bruna Romana-Souza, Samuel Santos Valença, Manuella Lanzetti
Chronic obstructive pulmonary disease (COPD) is an incurable and progressive disease. Emphysema is the principal manifestation of COPD, and the main cause of this condition is cigarette smoke (CS). Natural products have shown antioxidant and anti-inflammatory properties that can prevent acute lung inflammation and emphysema, but there are few reports in the literature regarding therapeutic approaches to emphysema. We hypothesized that supplementation with natural extracts would repair lung damage in emphysema caused by CS exposure...
August 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28886473/strategies-for-injury-prevention-in-brazilian-football-perceptions-of-physiotherapists-and-practices-of-premier-league-teams
#14
Maurício Couto Meurer, Marcelo Faria Silva, Bruno Manfredini Baroni
OBJECTIVES: To describe the physiotherapists perceptions and the current practices for injury prevention in elite football (soccer) clubs in Brazil. DESIGN: Cross-sectional study. SETTING: Group of Science in Sports & Exercise, Federal University of Healthy Sciences of Porto Alegre (Brazil). PARTICIPANTS: 16 of the 20 football clubs involved in the Brazilian premier league 2015. MAIN OUTCOME MEASURES: Physiotherapists answered a structured questionnaire...
July 25, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28882417/derivation-and-validation-model-for-hospital-hypoglycemia
#15
Javier Ena, Antonio Zapatero Gaviria, Marta Romero-Sánchez, Juana Carretero-Gómez, Francisco Javier Carrasco-Sánchez, José Vicente Segura-Heras, Ana Belkis Porto-Perez, Patricia Vázquez-Rodriguez, Concepción González-Becerra, Ricardo Gómez-Huelgas
BACKGROUND: An objective and simple prognostic model for hospitalized patients with hypoglycemia could be helpful in guiding initial intensity of treatment. METHODS: We carried out a derivation rule for hypoglycemia using data from a nationwide retrospective cohort study of patients with diabetes or hyperglycemia carried out in 2014 (n=839 patients). The rule for hypoglycemia was validated using a second data set from a nationwide retrospective cohort study carried out in 2016 (n=561 patients)...
September 4, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28878301/epa-dha-6-1-prevents-angiotensin-ii-induced-hypertension-and-endothelial-dysfunction-in-rats-role-of-nadph-oxidase-and-cox-derived-oxidative-stress
#16
Zahid Rasul Niazi, Grazielle C Silva, Thais Porto Ribeiro, Antonio J León-González, Mohamad Kassem, Abdur Mirajkar, Azhar Alvi, Malak Abbas, Faraj Zgheel, Valérie B Schini-Kerth, Cyril Auger
Eicosapentaenoic acid:docosahexaenoic acid (EPA:DHA) 6:1, an omega-3 polyunsaturated fatty acid formulation, has been shown to induce a sustained formation of endothelial nitric oxide (NO) synthase-derived NO, a major vasoprotective factor. This study examined whether chronic intake of EPA:DHA 6:1 prevents hypertension and endothelial dysfunction induced by angiotensin II (Ang II) in rats. Male Wister rats received orally corn oil or EPA:DHA 6:1 (500 mg kg(-1) per day) before chronic infusion of Ang II (0...
September 7, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28843061/cross-cultural-adaptation-and-validation-of-the-karitane-parenting-confidence-scale-of-maternal-confidence-assessment-for-use-in-brazil
#17
Lívia W Pereira, Juliana R Bernardi, Salete de Matos, Clecio H da Silva, Marcelo Z Goldani, Vera L Bosa
OBJECTIVES: To transculturally adapt and validate the Karitane Parenting Confidence Scale to the Brazilian Portuguese language and culture and verify the combination of the results with the maternal sociodemographic characteristics. METHODOLOGY: This is a validation and transcultural adaptation nestled in a longitudinal and observational study in Porto Alegre, RS, Brazil, assessing mother-infant pairs from different gestational and perinatal environments. The original authors authorized the translation into Brazilian Portuguese, unified version creation, back-translation, analysis by specialists, final version implementation, and acceptance...
August 23, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28832818/-sex-workers-and-public-health-intersections-vulnerabilities-and-resistance
#18
Alexandra Oliveira, Luís Fernandes
Since the 19th century with syphilis and most recently with AIDS, sex workers have been seen as a means for disease transmission and a public health problem that requires intervention. However, researchers have shown that in Western countries, HIV rates in people involved in commercial sex are low, except for in specific groups, such as intravenous drug users. Moreover, the risks faced by sex workers due to stigmatization and other forms of violence have been put into evidence. Based on an urban ethnography with street sex workers carried out in Porto (Portugal), between 2004 and 2005, this article discusses the social, labor, and legal vulnerabilities affecting people involved in commercial sex and how these interfere with their health...
April 2017: Salud Colectiva
https://www.readbyqxmd.com/read/28803786/distribution-of-hla-a-b-and-drb1-antigenic-groups-and-haplotypes-from-the-brazilian-bone-marrow-donor-registry-redome
#19
Leandro Torres, Luis Fernando da Silva Bouzas, Alexandre Almada, Luis Cristovão Moraes de Sobrino Porto, Eliana Abdelhay
To improve assistance for patients awaiting a bone marrow transplant from an unrelated donor, it is important to genetically characterize the Brazilian volunteer bone marrow donors registry (REDOME). Our objective was to describe the antigenic groups and haplotype frequencies of HLA-A, HLA-B and HLA-DRB1 in the five regions of Brazil and by self-reported ethnicity groups using the REDOME data. Our study included 3,038,286 individuals. HLA antigenic groups and haplotype frequencies were estimated using an Expectation-Maximization (EM) algorithm...
August 10, 2017: Human Immunology
https://www.readbyqxmd.com/read/28793129/clinical-characteristics-of-women-with-gestational-diabetes-comparison-of-two-cohorts-enrolled-20-years-apart-in-southern-brazil
#20
COMPARATIVE STUDY
Angela Jacob Reichelt, Letícia Schwerz Weinert, Livia Silveira Mastella, Vanessa Gnielka, Maria Amélia Campos, Vânia Naomi Hirakata, Maria Lúcia Rocha Oppermann, Sandra Pinho Silveiro, Maria Inês Schmidt
CONTEXT AND OBJECTIVE: The prevalence and characteristics of gestational diabetes mellitus (GDM) have changed over time, reflecting the nutritional transition and changes in diagnostic criteria. We aimed to evaluate characteristics of women with GDM over a 20-year interval. DESIGN AND SETTING: Comparison of two pregnancy cohorts enrolled in different periods, in university hospitals in Porto Alegre, Brazil: 1991 to 1993 (n = 216); and 2009 to 2013 (n = 375). METHODS: We applied two diagnostic criteria to the cohorts: International Association of Diabetes and Pregnancy Study Groups (IADPSG)/World Health Organization (WHO); and National Institute for Health and Care Excellence (NICE)...
July 2017: São Paulo Medical Journal, Revista Paulista de Medicina
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