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https://www.readbyqxmd.com/read/29473501/a-novel-finding-macrophages-involved-inflammation-participated-in-the-acute-aortic-dissection-complicated-with-acute-lung-injury
#1
Z Wu, Z Wang, P Xu, M Zhang, L Cheng, B Gong
BACKGROUND: The pathogenesis of acute aortic dissection (AAD) complicated with acute lung injury (ALI) is still not well defined. OBJECTIVE: We aim to investigate the roles of macrophages-derived matrix metalloproteinase 9 (MMP9) in the pathogenesis of AAD complicated with ALI and factors involves in the recruitment of macrophages. METHOD: This study included three parts: (i) determination of serum MMPs , AngII and MCP-1 in AAD complicated with/without ALI patients, nonruptured chronic aortic aneurysm patients or healthy volunteers using ELISA method...
February 22, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29465408/how-should-i-treat-a-bioresorbable-vascular-scaffold-edge-restenosis-and-intra-scaffold-dissection
#2
Christian Oliver Fallesen, Lisbeth Antonsen, Per Thayssen, Lisette Okkels Jensen, Pil Hyung Lee, Seung-Whan Lee, Seung-Jung Park, Elisabetta Moscarella, Giosafat Spitaleri, Salvatore Brugaletta
No abstract text is available yet for this article.
February 20, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29461983/corticosterone-impairs-flexible-adjustment-of-spatial-navigation-in-an-associative-place-reward-learning-task
#3
Silviu I Rusu, Jan V Lankelma, Jadin C Jackson, Laura A Van Mourik-Donga, Marian Joëls, Cyriel M A Pennartz
Cognitive challenges are often accompanied by a discharge of stress hormones, which in turn modulate multiple brain areas. Among these, the medial temporal lobe and the prefrontal cortex are critically involved in high-order cognitive functions such as learning, memory, and decision-making. Previous studies assessing the effects of corticosterone on spatial memory found an increase or a decrease in performance depending on the timing of stress hormone discharge relative to the behavioral task. Most of these studies, however, made use of aversively motivated behaviors, whereas less is known about corticosteroid effects on flexible learning during reward-driven spatial navigation...
February 14, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29456457/effect-of-ovarian-cancer-ascites-on-skov-3-cells-proteome-new-proteins-associated-with-aggressive-phenotype-in-epithelial-ovarian-cancer
#4
Alfredo Toledo-Leyva, Julio César Villegas-Pineda, Sergio Encarnación-Guevara, Dolores Gallardo-Rincón, Patricia Talamás-Rohana
Background: Epithelial ovarian cancer is the second most lethal gynecological cancer worldwide. Ascites can be found in all clinical stages, however in advanced disease stages IIIC and IV it is more frequent and could be massive, associated with worse prognosis. Due to the above, it was our interest to understanding how the ascites of ovarian cancer patients induces the mechanisms by which the cells present in it acquire a more aggressive phenotype and to know new proteins associated to this process...
2018: Proteome Science
https://www.readbyqxmd.com/read/29455053/the-becoming-of-methadone-in-kenya-how-an-intervention-s-implementation-constitutes-recovery-potential
#5
Tim Rhodes
This analysis treats the recent introduction of methadone treatment in Kenya as a case of 'evidence-making intervention'. Using 30 qualitative interviews with people in receipt of methadone treatment in Nairobi, Kenya, methadone's becoming is treated as an effect of its narrative and material implementations. The interviews are shown to enact a narrative of methadone recovery potential towards normalcy beyond addiction. Such recovery potential is materialised in practice through social interactions wherein methadone's embodied effects are seen to be believed...
February 10, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29450504/association-of-adenotonsillectomy-with-blood-pressure-among-hypertensive-and-nonhypertensive-children-with-obstructive-sleep-apnea
#6
Cho-Hsueh Lee, Kun-Tai Kang, Shuenn-Nan Chiu, I-Sheng Chang, Wen-Chin Weng, Pei-Lin Lee, Wei-Chung Hsu
Importance: Hypertension in childhood may continue into adulthood and lead to adverse cardiovascular outcomes. Evidence suggests that adenotonsillectomy for childhood obstructive sleep apnea (OSA) may be associated with blood pressure (BP) improvement. However, how adenotonsillectomy is associated with BP in hypertensive and nonhypertensive children with OSA remains unclear. Objective: To investigate disparities in BP changes after adenotonsillectomy in hypertensive and nonhypertensive children with OSA...
February 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29445392/how-many-parathyroid-glands-can-be-identified-during-thyroidectomy-evidence-based-data-for-medical-experts
#7
Elisabeth Gschwandtner, Rudolf Seemann, Claudia Bures, Lejla Preldzic, Eduard Szucsik, Michael Hermann
Background: The purpose of this study is to provide guidance for medical experts regarding malpractice claims on permanent hypoparathyroidism by analyzing the number of parathyroid glands (PGs) identified during thyroidectomy and the clinical outcome. Methods: Parathyroid findings were documented in a standardized protocol for 357 patients undergoing thyroidectomy and treated by a single specialized surgeon. The resected thyroid was routinely dissected for accidentally removed PGs with consecutive autotransplantation and the pathological report also described unintentionally resected PGs...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29445338/synaptic-homeostasis-and-allostasis-in-the-dentate-gyrus-caused-by-inflammatory-and-neuropathic-pain-conditions
#8
Rui-Rui Wang, Yan Wang, Su-Min Guan, Zhen Li, Saurabh Kokane, Fa-Le Cao, Wei Sun, Chun-Li Li, Ting He, Yan Yang, Qing Lin, Jun Chen
It has been generally accepted that pain can cause imbalance between excitation and inhibition (homeostasis) at the synaptic level. However, it remains poorly understood how this imbalance (allostasis) develops in the CNS under different pain conditions. Here, we analyzed the changes in both excitatory and inhibitory synaptic transmission and modulation of the dentate gyrus (DG) under two pain conditions with different etiology and duration. First, it was revealed that the functions of the input-output (I/O) curves for evoked excitatory postsynaptic currents (eEPSCs) following the perforant path (PP) stimulation were gained under both acute inflammatory and chronic neuropathic pain conditions relative to the controls...
2018: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/29443050/a-co-culture-method-to-investigate-the-crosstalk-between-x-ray-irradiated-caco-2-cells-and-pbmc
#9
Gabriele Babini, Jacopo Morini, Sofia Barbieri, Giorgio Baiocco, Giovanni Battista Ivaldi, Marco Liotta, Paola Tabarelli de Fatis, Andrea Ottolenghi
The protocol adopted in this work aims at unraveling how X-rays perturb the functioning of the intestinal barrier, focusing on the interplay between colorectal tumor cells and the immune system. Colorectal carcinoma is among the most common type of cancer, typically treated by surgery, chemotherapy, and radiotherapy. Advantages of radiotherapy in targeting the tumor are well known. However, even limited exposures of healthy tissues are of great concern, particularly regarding the effects on the intestinal barrier and the immune system...
January 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442297/a-single-center-cost-analysis-of-treating-primary-and-metastatic-brain-cancers-with-either-brain-laser-interstitial-thermal-therapy-litt-or-craniotomy
#10
Eric C Leuthardt, Jeff Voigt, Albert H Kim, Pete Sylvester
BACKGROUND: Brain laser interstitial thermal therapy (LITT) under magnetic resonance imaging (MRI) guidance has recently gained US clinical approval for the ablation of soft, neurological tissue. LITT is a minimally invasive alternative to craniotomy. OBJECTIVE: While safety and efficacy are the focus of most current LITT studies, it is unclear how acute care costs (inpatient care ± aftercare) of LITT compare to craniotomy in an academic medical center. Therefore, the purpose of this analysis is to examine these costs of using brain LITT under MRI guidance compared to craniotomy in complex anatomies...
March 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29438960/how-i-treat-myelodysplastic-syndromes-of-childhood
#11
Franco Locatelli, Brigitte Strahm
Pediatric myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders with an annual incidence of 1-4 cases/million, accounting for less than 5% of childhood hematological malignancies. MDS in children often occur in the context of inherited bone marrow failure syndromes, this representing a peculiarity of myelodysplasia diagnosed in the pediatric age. Moreover, germline syndromes predisposing individuals to develop MDS/acute myeloid leukemia have recently been identified, such as those caused by mutations in GATA2, ETV6, SRP72, and SAMD9/SAMD9-L Refractory cytopenia of childhood (RCC) is the most frequent pediatric MDS variant, showing specific histopathological features...
February 8, 2018: Blood
https://www.readbyqxmd.com/read/29433912/factors-influencing-emergency-department-care-of-young-children-at-risk-for-clinically-important-traumatic-brain-injury
#12
Tara Rhine, Shari L Wade, Nanhua Zhang, Huaiyu Zang, Stephanie Kennebeck, Lynn Babcock
OBJECTIVES: Care decisions for young children presenting to the emergency department (ED) with head injury are often challenging (e.g. whether to obtain neuroimaging). We sought to identify factors associated with acute management of children at-risk for clinically important traumatic brain injury (ciTBI) and describe symptom management. METHODS: Observational evaluation of children, ages 0-4years, presenting to a pediatric ED following minor head injury. Children with ≥1 risk element per the Pediatric Emergency Care Academic Research Network's decision rule were deemed "at-risk" for ciTBI...
January 31, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29432437/experimental-increase-in-baseline-corticosterone-level-reduces-oxidative-damage-and-enhances-innate-immune-response
#13
Csongor I Vágási, Laura Pătraș, Péter L Pap, Orsolya Vincze, Cosmin Mureșan, József Németh, Ádám Z Lendvai
Glucocorticoid (GC) hormones are significant regulators of homeostasis. The physiological effects of GCs critically depend on the time of exposure (short vs. long) as well as on their circulating levels (baseline vs. stress-induced). Previous experiments, in which chronic and high elevation of GC levels was induced, indicate that GCs impair both the activity of the immune system and the oxidative balance. Nonetheless, our knowledge on how mildly elevated GC levels, a situation much more common in nature, might influence homeostasis is limited...
2018: PloS One
https://www.readbyqxmd.com/read/29432218/electroencephalography-magnetoencephalography-and-source-localization-their-value-in-epilepsy
#14
Pierre Mégevand, Margitta Seeck
PURPOSE OF REVIEW: Source localization of cerebral activity using electroencephalography (EEG) or magnetoencephalography (MEG) can reveal noninvasively the generators of the abnormal signals recorded in epilepsy, such as interictal epileptic discharges (IEDs) and seizures. Here, we review recent progress showcasing the usefulness of these techniques in treating patients with drug-resistant epilepsy. RECENT FINDINGS: The source localization of IEDs by high-density EEG and MEG has now been proved in large patient cohorts to be accurate and clinically relevant, with positive and negative predictive values rivaling those of structural MRI...
February 9, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29429551/dermatology-and-immunoglobulin-therapy-who-to-treat-and-how-to-administer-immunoglobulins
#15
F J Navarro-Triviño, I Pérez-López, R Ruíz-Villaverde
Intravenous immunoglobulin (IVIG) replacement therapy has been used in immune deficiency diseases for more than 50 years. The indications for this treatment have evolved, however, and IVIG therapy is now used in various diseases in which the immune system plays a prominent role. IVIG therapy has carved out a niche in dermatology for the treatment of such conditions as dermatomyositis, autoimmune bullous diseases, and toxic epidermal necrolysis. Special attention has been paid to this therapy in recent years...
February 8, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29427652/evaluating-the-abuse-potential-of-psychedelic-drugs-for-medical-use-in-humans
#16
REVIEW
David J Heal, Jane Gosden, Sharon L Smith
Psychedelics comprise drugs come from various pharmacological classes including 5-HT 2A agonists, indirect 5-HT agonists, e.g. MDMA, NMDA antagonists and κ-opioid receptor agonists. There is resurgence in developing psychedelics to treat psychiatric disorders with high unmet clinical need. Many, but not all, psychedelics are schedule 1 controlled drugs (CDs), i.e. no approved medical use. For existing psychedelics in development, regulatory approval will require a move from schedule 1 to a CD schedule for drugs with medical use, i...
February 7, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29427482/how-to-improve-access-to-therapy-in-hepatitis-b-patients
#17
REVIEW
Miroslava Subic, Fabien Zoulim
Despite the availability of a preventive vaccine and active antiviral treatments that stop disease progression and reduce the risk of hepatocellular carcinoma, hepatitis B is still a major public health problem. Only an estimated 10% of the 257 million people living with HBV have been diagnosed and as few as 1% are being adequately treated. Barriers to diagnosis and treatment include: (i) limited awareness and lack of knowledge about HBV infection and HBV-related diseases; (ii) under-diagnosis with insufficient screening and referral to care; (iii) limited treatment due to drug availability, costs, reimbursement policies and the need for long-term or life-long therapy...
February 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29423546/association-between-incision-technique-for-hamstring-tendon-harvest-in-anterior-cruciate-ligament-reconstruction-and-the-risk-of-injury-to-the-infra-patellar-branch-of-the-saphenous-nerve-a-meta-analysis
#18
REVIEW
Alberto Grassi, Francesco Perdisa, Kristian Samuelsson, Eleonor Svantesson, Matteo Romagnoli, Federico Raggi, Teide Gaziano, Massimiliano Mosca, Olufemi Ayeni, Stefano Zaffagnini
PURPOSE: To determine how the incision technique for hamstring tendon (HT) harvest in anterior cruciate ligament (ACL) reconstruction affects the risk of injury to the IPBSN and clinical outcome. METHODS: A systematic literature search of the MEDLINE/Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL) and EBSCOhost electronic databases and clinicaltrials.gov for unpublished studies was performed to identify comparative studies investigating injury to the IPBSN after HT ACL reconstruction by comparing at least two different incision techniques...
February 8, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29422097/re-excision-and-survival-following-breast-conserving-surgery-in-early-stage-breast-cancer-patients-a-population-based-study
#19
Stacey Fisher, Yutaka Yasui, Kelly Dabbs, Marcy Winget
BACKGROUND: Increasing population-based evidence suggests that patients who receive breast conserving surgery (BCS) plus radiotherapy have superior survival than those who receive mastectomy. It is unclear, however, how BCS followed by re-excision is associated with all-cause and breast cancer-specific mortality, and whether the BCS survival advantage is maintained if re-excision is needed. The aim of this study was to investigate the clinical, patient, provider and geographic variation associated with receipt of re-excision surgery, and to examine the relationship between re-excision and all-cause and breast cancer-specific mortality...
February 8, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29420751/enhanced-multi-service-markets-an-evolution-in-military-health-system-governance
#20
Ronald P Hudak, Rebecca Russell, P Paul Toland
Background: The evolution of governance models for the Military Health System's (MHS) large hospitals, called medical treatment facilities (MTFs), has culminated with the effort to implement Enhanced Multi-Service Markets (eMSM). The term eMSM refers to two separate concepts. First, MSM refers to those geographic areas, that is, markets, which have the following characteristics: they have MTFs that are operated by two or more Department of Defense (DoD) Services, that is, Army, Navy, or Air Force; there is a large beneficiary population; there is a substantial amount of direct care (i...
February 6, 2018: Military Medicine
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