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https://www.readbyqxmd.com/read/29240787/brd3-4-inhibition-and-flt3-ligand-deprivation-target-pathways-that-are-essential-for-the-survival-of-human-mll-af9-leukemic-cells
#1
Marco Carretta, Annet Z Brouwers-Vos, Matthieu Bosman, Sarah J Horton, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa
In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. We show that MLL-AF9 cells critically depend on FLT3-ligand induced pathways as well as on BRD3/4 for their survival. We evaluated the in vitro and in vivo efficacy of the BRD3/4 inhibitor I-BET151 in various human MLL-AF9 (primary) models and patient samples and analyzed the transcriptome changes following treatment. To further understand the mode of action of BRD3/4 inhibition, we performed ChIP-seq experiments on the MLL-AF9 complex in THP1 cells and compared it to RNA-seq data of I-BET151 treated cells...
2017: PloS One
https://www.readbyqxmd.com/read/29239280/perceived-injustice-and-its-correlates-after-mild-traumatic-brain-injury
#2
Grant L Iverson, Douglas P Terry, Justin E Karr, William Panenka, Noah D Silverberg
Perceived injustice is a belief that one has been treated unfairly, disrespectfully, and is suffering unnecessarily as a result of another person's actions. Perceived injustice predicts chronic disability after musculoskeletal injury, but to our knowledge, has not been empirically studied in people with mild traumatic brain injuries (MTBIs). We examined perceived injustice and its correlates in patients who were slow to recover from MTBI. Patients (N=102) were recruited from four concussion clinics. The sample was on average 41...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29239192/-combined-regimens-in-immunotherapy
#3
B Melichar, M Spisarová
The advent of immunotherapy has changed our concept of how to manage metastatic disease. With the exception of relatively rare tumors, the treatment of metastatic cancer is still considered as palliative, and in systemic treatment immunotherapy is often selected, considering better tolerance. Immunotherapy opens the perspective of a long-term, possibly durable, response, and, in contrast to other approaches to targeted therapy, is active across a spectrum of tumors. Combined regimens that increase the efficacy, given the context, are thus of importance...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29238670/specific-organ-targeted-vestibular-physiotherapy-the-pivot-in-the-contemporary-management-of-vertigo-and-imbalance
#4
EDITORIAL
Anirban Biswas, Bibhas Barui
Introduction: Advancements in our understanding of vestibular physiology and how it is changes in different diseases have established that of the three therapeutic approaches to treat disorders of the vestibular system viz. pharmacotherapy, surgery and physical therapy, it is the later i.e., physical therapy which is the most efficacious modality in the management of balance disorders. The futility of vestibular sedatives in the correction of vestibular disorders and in the restoration of balance and the very limited role of surgery has now been recognised...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29236668/-claude-bernard-and-nicotinic-receptors-from-the-neuromuscular-junction-to-tobacco-weaning
#5
Laurent Monassier
Claude Bernard (1813-1878) was fascinated by the pharmacological mechanisms of poisons. In particular, using a huge amount of ingenious and robust experiments, he demonstrated the peripheral toxic action of the natural compound curare. His work generated controversies in a period where scientific methodology and technical development followed the progression of concepts and ideas. From his intense debates with Albert Vulpian emerged the location of curare's toxicity at the neuromuscular junction. These two fascinating scientists could not imagine how important were these discoveries which allowed John Langley to propose the concept of receptor early in the 20th century...
2017: Biologie Aujourd'hui
https://www.readbyqxmd.com/read/29230306/cultural-shift-in-mental-illness-a-comparison-of-stress-responses-in-world-war-i-and-the-vietnam-war
#6
Rasjid Skinner, Paul M Kaplick
Objectives: Post-traumatic stress disorder is an established diagnostic category. In particular, over the past 20 years, there has been an interest in culture as a fundamental factor in post-traumatic stress disorder symptom manifestation. However, only a very limited portion of this literature studies the historical variability of post-traumatic stress within a particular culture. Design: Therefore, this study examines whether stress responses to violence associated with armed conflicts have been a culturally stable reaction in Western troops...
December 2017: JRSM Open
https://www.readbyqxmd.com/read/29228960/cross-sectional-survey-on-the-use-and-impact-of-the-danish-national-antibiotic-use-guidelines-for-companion-animal-practice
#7
Lisbeth Rem Jessen, Tina Møller Sørensen, Zenia Littau Lilja, Maja Kristensen, Tine Hald, Peter Damborg
BACKGROUND: The Danish antibiotic use guidelines for companion animal practice were published by the Danish Veterinary Association in 2012. Since then, national surveillance data indicate a 10% reduction in the total use of antibiotics for companion animals, particularly a marked reduction in the use of third generation cephalosporins. The aim of the study was to assess if and how the guidelines have impacted diagnostic and antibiotic prescription habits of the users, and to identify user perceived barriers to implementation...
December 11, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29224312/-how-i-diagnose-and-treat-post-transplant-lymphoproliferative-disorders-after-allogeneic-hematopoietic-stem-cell-transplantation
#8
L P Xu
No abstract text is available yet for this article.
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29224311/-how-i-treat-febrile-neutropenic-patients-with-acute-leukemia-after-chemotherapy
#9
J D Hu, T Yang
No abstract text is available yet for this article.
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29220347/assessing-the-benefits-of-five-years-of-different-approaches-to-treatment-of-urogenital-schistosomiasis-a-score-project-in-northern-mozambique
#10
Anna E Phillips, Pedro H Gazzinelli-Guimaraes, Herminio O Aurelio, Josefo Ferro, Rassul Nala, Michelle Clements, Charles H King, Alan Fenwick, Fiona M Fleming, Neerav Dhanani
BACKGROUND: In Mozambique, schistosomiasis is highly endemic across the whole country. The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) coordinates a five-year study that has been implemented in various African countries, including Mozambique. The overall goal of SCORE was to better understand how to best apply preventive chemotherapy with praziquantel (PZQ) for schistosomiasis control by evaluating the impact of alternative treatment approaches. METHODS: This was a cluster-randomised trial that compared the impact of different treatment strategies in study areas with prevalence among school children of ≥21% S...
December 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29218855/effects-of-prior-exposure-to-antibiotics-on-bacterial-adaptation-to-phages
#11
Flor I Arias-Sánchez, Richard C Allen, Alex R Hall
Understanding adaptation to complex environments requires information about how exposure to one selection pressure affects adaptation to others. For bacteria, antibiotics and viral parasites (phages) are two of the most common selection pressures and are both relevant for treatment of bacterial infections: increasing antibiotic resistance is generating significant interest in using phages in addition or as an alternative to antibiotics. However, we lack knowledge of how exposure to antibiotics affects bacterial responses to phages...
December 8, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29218254/bone-microenvironment-has-an-influence-on-the-histological-response-of-osteosarcoma-to-chemotherapy-retrospective-analysis-and-preclinical-modeling
#12
Vincent Crenn, Kevin Biteau, Jérôme Amiaud, Clotilde Dumars, Romain Guiho, Luciano Vidal, Louis-Romée Le Nail, Dominique Heymann, Anne Moreau, François Gouin, Françoise Redini
Osteosarcoma, the most common malignant primary bone tumor, is currently treated with chemotherapy and surgery. The effectiveness of chemotherapy is evaluated by means of histological analysis of tumor necrosis, known as "the Huvos score". However, 25% of the patients initially considered good responders will relapse. In our practice, strong tissue heterogeneity around the residual viable cells of the osteosarcoma is observed, but this is not taken into account by the Huvos score, as it is only an average. The objective is to determine whether heterogeneity in the osteosarcoma's microenvironment can play a role in the histological response to chemotherapy...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29216987/catheter-ablation-of-ventricular-tachycardia-in-structurally-normal-hearts-indications-strategies-and-outcomes-part-i
#13
REVIEW
Srinivas R Dukkipati, Subbarao Choudry, Jacob S Koruth, Marc A Miller, William Whang, Vivek Y Reddy
Catheter ablation of ventricular tachycardia (VT) is being increasingly performed; yet, there is often confusion regarding indications, outcomes, and how to identify those patient populations most likely to benefit. The management strategy differs between those with structural heart disease and those without. For the former, an implantable cardioverter-defibrillator (ICD) is typically required due to an elevated risk for sudden cardiac death, and catheter ablation can be used as adjunctive therapy to treat or prevent repetitive ICD therapies...
December 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29216720/testosterone-replacement-therapy-trt-and-its-effect-on-bone-marrow-how-serious-is-it-and-is-there-a-true-polyglobulia
#14
M Levcikova, J Breza, J Luha, J Dubravicky, E Kovacova, J Fillo
INTRODUCTION: TRT in men with testosterone deficiency syndrome (TDS) had multiple positive effects and restore a quality of life of affected men. Polyglobulia is the most common dose-limiting adverse effect of TRT, but the mechanisms of TRT-mediated erythropoesis remain unclear. In this study, we evaluated long term haematological side effects of TRT: polyglobulia, elevated hemoglobin (Hb) and haematocrit (Ht). METHODS: In a cross-sectional descriptive study, the authors treated 69 men with TDS and the average age 59 years and the follow-up period 81...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29208581/how-should-i-treat-a-left-persistent-superior-vena-cava-with-unroofed-coronary-sinus-associated-with-severe-stenosis-and-regurgitation-of-aortic-homograft-placed-in-the-tricuspid-position
#15
Valeria Pergola, Giovanni Di Salvo, Mohammed Al-Admawi, Bahaa Fadel, Mansour Al-Jufan, Massimo Chessa, Jonathan McGuinness
No abstract text is available yet for this article.
December 8, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29207344/nod1-and-nod2-molecular-targets-in-prevention-and-treatment-of-infectious-diseases
#16
REVIEW
Mikhail V Pashenkov, Yulia A Dagil, Boris V Pinegin
Nucleotide-binding oligomerization domain (NOD) 1 and NOD2 are pattern-recognition receptors responsible for sensing fragments of bacterial peptidoglycan known as muropeptides. Stimulation of innate immunity by systemic or local administration of NOD1 and NOD2 agonists is an attractive means to prevent and treat infectious diseases. In this review, we discuss novel data concerning structural features of selective and non-selective (dual) NOD1 and NOD2 agonists, main signaling pathways and biological effects induced by NOD1 and NOD2 stimulation, including induction of pro-inflammatory cytokines, type I interferons and antimicrobial peptides, induction of autophagy, alterations of metabolism...
December 2, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29201766/are-synbiotics-added-to-the-standard-therapy-to-eradicate-helicobacter-pylori-in-children-beneficial-a-randomized-controlled-study
#17
Banu N Şirvan, Merve K Usta, Nurav U Kizilkan, Nafive Urganci
Aim: We aimed to evaluate the role of the addition of Bifidobacterium /actis-containing synbiotic to the triple therapy in the case of He/icobacter py/ori eradication, the dyspeptic symptoms, and reducing the side effects of antibiotics. Materials and methods: A total of 104 children aged between 5 and 17 years, who were histopathologically diagnosed with H. py/ori were enrolled in this study, of whom 100 were included in the analysis. Patients were randomly classified into two groups...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29197607/inflammatory-response-modulation-through-a-ppar%C3%AE-agonist-during-surgically-induced-visceral-ischemia-in-an-animal-model
#18
Bianca Pane, Valerio Gazzola, Giovanni Spinella, Paola Bagnato, Federica Grillo, Valerio Gaetano Vellone, Domenico Palombo
BACKGROUND: Ischemia / reperfusion (I/R) injury represents one of the most severe complications in vascular surgery where cross-clamping of the aorta and subsequent visceral ischemia are a recurrent issue. The literature describes a family of nuclear receptors, i.e., peroxisome-proliferator activated receptors (PPARs), in particular PPARγ isoform, which are important modulators of vascular inflammation resulting from I/R injury. The aim of our study is to evaluate how PPARγ agonist administration could reduce local and systemic inflammatory response after I/R injury during aortic supraceliac clamping in animal model...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29196027/cancer-chemotherapy-in-early-life-significantly-alters-the-maturation-of-pain-processing
#19
G J Hathway, Emily Murphy, Joseph Lloyd, Charles Greenspon, R P Hulse
Advances in paediatric cancer treatment have led to a ten year survival rate greater than 75%. Platinum-based chemotherapies (e.g.cisplatin) induce peripheral sensory neuropathy in adult and paedriatric cancer patients. The period from birth through to adulthood represents a period of maturation within nociceptive systems. Here we investigated how cisplatin impacts upon postnatal maturation of nociceptive systems. Neonatal Wistar rats (Postnatal day (P) 7) were injected (i.p.) daily with either vehicle (PBS) or cisplatin (1mg/kg) for five consecutive days...
November 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/29195588/characteristics-and-clinical-treatment-of-tobacco-smokers-enrolled-in-a-va-substance-use-disorders-clinic
#20
Julie C Gass, David H Morris, Jamie Winters, Joseph W VanderVeen, Stephen Chermack
Individuals with a substance use disorder (SUD) diagnosis are more than twice as likely to smoke cigarettes as the general population. Emerging research has suggested that treating a substance use disorder simultaneously with tobacco use leads to a higher rate of treatment success for both substances. Despite this, substance use treatment protocols tend not to focus on tobacco use; in fact, traditional substance use treatments often discourage patients from attempting to quit smoking. One rationale is that patients may not be motivated to quit smoking...
January 2018: Journal of Substance Abuse Treatment
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