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https://www.readbyqxmd.com/read/28086992/therapies-for-bruxism-a-systematic-review-and-network-meta-analysis-protocol
#1
Mauro Elias Mesko, Brian Hutton, Jovito Adiel Skupien, Rafael Sarkis-Onofre, David Moher, Tatiana Pereira-Cenci
BACKGROUND: Bruxism is a sleep disorder characterized by grinding and clenching of the teeth that may be related to irreversible tooth injuries. It is a prevalent condition occurring in up to 31% of adults. However, there is no definitive answer as to which of the many currently available treatments (including drug therapy, intramuscular injections, physiotherapy, biofeedback, kinesiotherapy, use of intraoral devices, or psychological therapy) is the best for the clinical management of the different manifestations of bruxism...
January 13, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28077845/when-words-were-wanted-but-woefully-wanting-we-waged-war-with-chess
#2
Burton Norman Seitler
What do you say to a child who rarely speaks? How do you work with such a youngster? What are the sine qua nons or guiding principles upon which analysts can draw? And, how do we know if we are being helpful? Sam was 9-years when I began treating him. He was extremely withdrawn and rarely spoke more than a few words. Instead, he mainly played chess. I did not know at first whether Sam's taciturn demeanor was due to shyness, limited verbal abilities, or the stultifying effects of trauma. Fortuitously, during one of many seemingly "innocent" games of chess, Sam happened to make a bold move, to which I admiringly remarked, "What a move, you're killing me...
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28076321/secretion-modification-region-derived-peptide-blocks-exosome-release-and-mediates-cell-cycle-arrest-in-breast-cancer-cells
#3
Ming-Bo Huang, Ruben R Gonzalez, James Lillard, Vincent C Bond
PURPOSE: Discovery and development of a novel anticancer PEG-SMR-Clu peptide to prevent breast cancer metastasis. How breast cancer cells and primary mammary epithelial cells interact and communicate with each other to promote tumorigenesis and how to prevent tumor metastasis has long been a concern of researchers. Cancer cells secrete exosomes containing proteins and RNA. These factors can influence tumor development by directly targeting cancer cells and tumor stroma. In this study, we determined the effects of a peptide as an inhibitor of exosome secretion on breast tumors...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28074346/actively-negotiating-the-mind-body-divide-how-clozapine-treated-schizophrenia-patients-make-health-for-themselves
#4
Julia E H Brown, Simone Dennis
It is well recognised that antipsychotic treatments impact the whole body, not just the target area of the brain. For people with refractory schizophrenia on clozapine, the gold standard antipsychotic treatment in England and Australia, the separation of mental and physical regimes of health is particularly pronounced, resulting in multiple, compartmentalised treatment registers. Clinicians often focus on the mental health aspects of clozapine use, using physical indicators to determine whether treatment can continue...
January 10, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/28059696/can-i-help-you-information-sharing-in-online-discussion-forums-by-people-living-with-a-long-term-condition
#5
Carol S Bond, Osman Hassan Ahmed
BACKGROUND: Peer-to-peer health care is increasing, especially amongst people living with a long-term condition. How information is shared is, however, sometimes of concern to health care professionals. OBJECTIVE: This study explored what information is being shared on health-related discussion boards and identified the approaches people used to signpost their peers to information. METHODS: This study was conducted using a qualitative content analysis methodology to explore information shared on discussion boards for people living with diabetes...
November 10, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28049648/vitamin-k-dependent-carboxylation-of-matrix-gla-protein-influences-the-risk-of-calciphylaxis
#6
Sagar U Nigwekar, Donald B Bloch, Rosalynn M Nazarian, Cees Vermeer, Sarah L Booth, Dihua Xu, Ravi I Thadhani, Rajeev Malhotra
Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification. The ability of MGP to inhibit calcification requires the activity of a vitamin K-dependent enzyme, which mediates MGP carboxylation. We investigated how MGP carboxylation influences the risk of calciphylaxis in adult patients receiving dialysis and examined the effects of vitamin K deficiency on MGP carboxylation. Our study included 20 patients receiving hemodialysis with calciphylaxis (cases) and 20 patients receiving hemodialysis without calciphylaxis (controls) matched for age, sex, race, and warfarin use...
January 3, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28047116/su-g-tep3-08-pre-clinical-radionuclide-therapy-dosimetry-in-several-pediatric-cancer-xenografts
#7
I Marsh, M Otto, J Weichert, D Baiu, B Bednarz
PURPOSE: The focus of this work is to perform Monte Carlo-based dosimetry for several pediatric cancer xenografts in mice treated with a novel radiopharmaceutical (131) I-CLR1404. METHODS: Four mice for each tumor cell line were injected with 8-13 µCi/g of the (124) 124I-CLR1404. PET/CT images of each individual mouse were acquired at 5-6 time points over the span of 96-170 hours post-injection. Following acquisition, the images were co-registered, resampled, rescaled, corrected for partial volume effects (PVE), and masked...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046705/su-f-t-202-an-evaluation-method-of-lifetime-attributable-risk-for-comparing-between-proton-beam-therapy-and-intensity-modulated-x-ray-therapy-for-pediatric-cancer-patients-by-averaging-four-dose-response-models-for-carcinoma-induction
#8
M Tamura, Y Ito, H Sakurai, M Mizumoto, S Kamizawa, S Murayama, H Yamashita, S Takao, R Suzuki, H Shirato
PURPOSE: To examine how much lifetime attributable risk (LAR) as an in silico surrogate marker of radiation-induced secondary cancer would be lowered by using proton beam therapy (PBT) in place of intensity modulated x-ray therapy (IMXT) in pediatric patients. METHODS: From 242 pediatric patients with cancers who were treated with PBT, 26 patients were selected by random sampling after stratification into four categories: a) brain, head, and neck, b) thoracic, c) abdominal, and d) whole craniospinal (WCNS) irradiation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041727/fate-of-escherichia-coli-o157-h7-and-bacterial-diversity-in-corn-silage-contaminated-with-the-pathogen-and-treated-with-chemical-or-microbial-additives
#9
I M Ogunade, Y Jiang, D H Kim, A A Pech Cervantes, K G Arriola, D Vyas, Z G Weinberg, K C Jeong, A T Adesogan
Inhibiting the growth of Escherichia coli O157:H7 (EC) in feeds may prevent the transmission or cycling of the pathogen on farms. The first objective of this study was to examine if addition of propionic acid or microbial inoculants would inhibit the growth of EC during ensiling, at silo opening, or after aerobic exposure. The second objective was to examine how additives affected the bacterial community composition in corn silage. Corn forage was harvested at approximately 35% dry matter, chopped to a theoretical length of cut of 10 mm, and ensiled after treatment with one of the following: (1) distilled water (control); (2) 1 × 10(5) cfu/g of EC (ECCH); (3) EC and 1 × 10(6) cfu/g of Lactobacillus plantarum (ECLP); (4) EC and 1 × 10(6) cfu/g of Lactobacillus buchneri (ECLB); and (5) EC and 2...
December 29, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28040988/how-will-cancer-survivors-use-survivorship-care-plans
#10
Nicole A Kinnane, Amanda J Piper, Michael Jefford
BACKGROUND: Survivorship care plans (SCPs) are internationally endorsed as an important tool to enhance post-treatment survivorship care. To support broad implementation of SCPs, we investigated survivors' preferences regarding SCPs. MATERIAL AND METHODS: The study was conducted at a comprehensive cancer center. Eligible patients from 10 clinical services, generally up to 12 months following end of treatment (EOT) were approached in clinics or via telephone. A purpose-designed survey assessed survivors' intended use of a SCP and preferences regarding format and content...
December 31, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/28035839/high-performing-windowfarm-hydroponic-system-transcriptomes-of-fresh-produce-and-microbial-communities-in-response-to-beneficial-bacterial-treatment
#11
Seungjun Lee, Ruisheng An, Parwinder Grewal, Zhongtang Yu, Zuzana Borherova, Jiyoung Lee
Beneficial microorganisms play an important role in enhancing plant health, especially by promoting resistance to plant pathogen infection. The purpose of this study was to gain an understanding of such protection by i) examining the responses of fresh produce (lettuce) to beneficial treatments in their transcriptomes, ii) comparing biological (bacteria, fungi, and oomycete) communities and their diversity when treated with Pseudomonas chlororaphis (beneficial bacterium) in windowfarm hydroponic systems, and iii) identifying the microorganisms in root areas and water...
December 30, 2016: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28034892/how-i-treat-anemia-in-pregnancy-iron-cobalamin-and-folate
#12
Maureen M Achebe, Anat Gafter-Gvili
Anemia of pregnancy is considered a global health problem, affecting almost 50% of pregnant women. Anemia is an important risk factor for both fetal and maternal morbidity. The purpose of this article is to discuss diagnosis and management of the most frequent causes of anemia in pregnancy: iron, cobalamin and folate deficiencies. This paper considers three clinical cases. Iron deficiency is the most common cause. The laboratory tests that define iron deficiency, the recognition of developmental delays and cognitive abnormalities in iron-deficient neonates and the literature addressing the efficacy and safety of intravenous iron in pregnancy are reviewed...
December 29, 2016: Blood
https://www.readbyqxmd.com/read/28034871/how-i-evaluate-and-treat-thrombocytopenia-in-the-intensive-care-unit-patient
#13
REVIEW
Andreas Greinacher, Sixten Selleng
Multiple causes (pseudothrombocytopenia, hemodilution, increased consumption, decreased production, increased sequestration, and immune-mediated destruction of platelets) alone or in combination make thrombocytopenia very common in intensive care unit (ICU) patients. Persisting thrombocytopenia in critically ill patients is associated with, but not causative of, increased mortality. Identification of the underlying cause is key for management decisions in individual patients. While platelet transfusion might be indicated in patients with impaired platelet production or increased platelet destruction, it could be deleterious in patients with increased intravascular platelet activation...
December 29, 2016: Blood
https://www.readbyqxmd.com/read/28028654/potential-mediators-in-parenting-and-family-intervention-quality-of-mediation-analyses
#14
REVIEW
Chandni C Patel, Amanda J Fairchild, Ronald J Prinz
Parenting and family interventions have repeatedly shown effectiveness in preventing and treating a range of youth outcomes. Accordingly, investigators in this area have conducted a number of studies using statistical mediation to examine some of the potential mechanisms of action by which these interventions work. This review examined from a methodological perspective in what ways and how well the family-based intervention studies tested statistical mediation. A systematic search identified 73 published outcome studies that tested mediation for family-based interventions across a wide range of child and adolescent outcomes (i...
December 27, 2016: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/28028314/redirecting-t-cells-to-eradicate-b-cell-acute-lymphoblastic-leukemia-bispecific-t-cell-engagers-and-chimeric-antigen-receptors
#15
REVIEW
I Aldoss, R C Bargou, D Nagorsen, G R Friberg, P A Baeuerle, S J Forman
Recent advances in antibody technology to harness T-cells for cancer immunotherapy, particularly in the difficult-to-treat setting of relapsed or refractory acute lymphoblastic leukemia (r/r ALL), has led to innovative methods for directing cytotoxic T-cells to specific surface antigens on cancer cells. One approach involves administration of soluble bispecific (or dual-affinity) antibody-based constructs that temporarily bridge T-cells and cancer cells. Another approach infuses ex vivo-engineered T-cells that express a surface plasma membrane-inserted antibody construct called a chimeric antigen receptor (CAR)...
December 28, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28027366/us-spending-on-personal-health-care-and-public-health-1996-2013
#16
Joseph L Dieleman, Ranju Baral, Maxwell Birger, Anthony L Bui, Anne Bulchis, Abigail Chapin, Hannah Hamavid, Cody Horst, Elizabeth K Johnson, Jonathan Joseph, Rouselle Lavado, Liya Lomsadze, Alex Reynolds, Ellen Squires, Madeline Campbell, Brendan DeCenso, Daniel Dicker, Abraham D Flaxman, Rose Gabert, Tina Highfill, Mohsen Naghavi, Noelle Nightingale, Tara Templin, Martin I Tobias, Theo Vos, Christopher J L Murray
Importance: US health care spending has continued to increase, and now accounts for more than 17% of the US economy. Despite the size and growth of this spending, little is known about how spending on each condition varies by age and across time. Objective: To systematically and comprehensively estimate US spending on personal health care and public health, according to condition, age and sex group, and type of care. Design and Setting: Government budgets, insurance claims, facility surveys, household surveys, and official US records from 1996 through 2013 were collected and combined...
27, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28018836/novel-therapeutics-for-addiction-behavioral-and-neuroeconomic-approaches
#17
Warren K Bickel, Alexandra M Mellis, Sarah E Snider, Lara Moody, Jeffrey S Stein, Amanda J Quisenberry
The maturing fields of behavioral- and neuro-economics provides conceptual understanding of the Competing Neurobehavioral Decision Systems theory (CNDS) and reinforcer pathology (i.e. high valuation of and excessive preference for drug reinforcers) allowing us to coherently categorize treatments into a theoretically comprehensive framework of addiction. In this chapter, we identify and clarify how existing and novel interventions can ameliorate reinforcer pathology in light of the CNDS and be leveraged to treat addiction...
September 2016: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/28018772/understanding-how-to-prevent-and-treat-adverse-events-of-fillers-and-neuromodulators
#18
Glynis Ablon
Experience teaches cosmetic surgeons to become good, but avoiding and treating adverse events make them great. In no area is this more true than in cosmetic procedures involving fillers and neuromodulators. By utilizing knowledge of materials and anatomy involved, specialists seek to avoid complications. A well-trained physician is able to reduce the sequelae from an adverse event by acting promptly using algorithms and a methodical approach to treatments. In this article I discuss the difference between perceived and true complications from fillers and neuromodulators, how to avoid, what to look for and how to treat to provide patients with the best possible outcomes, and make the physicians life less stressful...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28018534/does-psychological-safety-impact-the-clinical-learning-environment-for-resident-physicians-results-from-the-va-s-learners-perceptions-survey
#19
Karina D Torralba, Lawrence K Loo, John M Byrne, Samuel Baz, Grant W Cannon, Sheri A Keitz, Annie B Wicker, Steven S Henley, T Michael Kashner
BACKGROUND : Psychological safety (PS) is the perception that it is safe to take interpersonal risks in the work environment. In teaching hospitals, PS may influence the clinical learning environment for trainees. OBJECTIVE : We assessed whether resident physicians believe they are psychologically safe, and if PS is associated with how they rate satisfaction with their clinical learning experience. METHODS : Data were extracted from the Learners' Perceptions Survey (LPS) of residents who rotated through a Department of Veterans Affairs health care facility for academic years 2011-2014...
December 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28009478/local-effects-on-airway-inflammation-and-systemic-uptake-of-5-nm-pegylated-and-citrated-gold-nanoparticles-in-asthmatic-mice
#20
Albert J Omlor, Duc D Le, Janine Schlicker, Matthias Hannig, Raphael Ewen, Sebastian Heck, Christian Herr, Annette Kraegeloh, Christina Hein, Ralf Kautenburger, Guido Kickelbick, Robert Bals, Juliane Nguyen, Q Thai Dinh
Nanotechnology is showing promise in many medical applications such as drug delivery and hyperthermia. Nanoparticles administered to the respiratory tract cause local reactions and cross the blood-air barrier, thereby providing a means for easy systemic administration but also a potential source of toxicity. Little is known about how these effects are influenced by preexisting airway diseases such as asthma. Here, BALB/c mice are treated according to the ovalbumin (OVA) asthma protocol to promote allergic airway inflammation...
December 23, 2016: Small
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