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https://www.readbyqxmd.com/read/29046609/nps-and-online-wom-investigating-the-relationship-between-customers-promoter-scores-and-ewom-behavior
#1
Néomie Raassens, Hans Haans
The Net Promoter Score (NPS) is, according to Reichheld, the single most reliable indicator of company growth, and many companies use this recommendation-based technique for measuring customer loyalty. Despite its widespread adoption by many companies across multiple industries, the debate about NPS goes on. A major concern is that managers treat NPS as being equivalent across customers, which is often very misleading. By using a unique data set that combines customers' promoter scores and online word-of-mouth (eWOM) behavior, this research studies how individual customers' promoter scores are related to eWOM, including its relationship with the three categories of customers that are identified by the NPS paradigm (i...
August 2017: J Serv Res
https://www.readbyqxmd.com/read/29040570/cumulative-live-birth-rates-following-miscarriage-in-an-initial-complete-cycle-of-ivf-a-retrospective-cohort-study-of-112-549-women
#2
Natalie J Cameron, Siladitya Bhattacharya, Sohinee Bhattacharya, David J McLernon
STUDY QUESTION: In women undergoing IVF/ICSI who miscarry in their first complete cycle, what is the chance of a live birth in subsequent complete cycles, and how does this compare with those whose first complete cycle ends with live birth or without a pregnancy? SUMMARY ANSWER: After two further complete cycles of IVF/ICSI, women who had miscarried or had a live birth in their first complete cycle had a higher chance of live birth (40.9 and 49.0%, respectively) than those who had no pregnancies (30...
September 20, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040255/how-i-treat-stage-iv-non-small-cell-lung-cancer-in-the-absence-of-any-actionable-oncogenic-driver
#3
Mark A Socinski
No abstract text is available yet for this article.
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29034850/pseudomonas-aeruginosa-variants-obtained-from-veterinary-clinical-samples-reveal-a-role-for-cyclic-di-gmp-in-biofilm-formation-and-colony-morphology
#4
Maria T Brock, Galya C Fedderly, Grace I Borlee, Michael M Russell, Liliana K Filipowska, Doreene R Hyatt, Ryan A Ferris, Bradley R Borlee
Overuse of antibiotics is contributing to an emerging antimicrobial resistance crisis. To better understand how bacteria adapt tolerance and resist antibiotic treatment, Pseudomonas aeruginosa isolates obtained from infection sites sampled from companion animals were collected and evaluated for phenotypic differences. Selected pairs of clonal isolates were obtained from individual infection samples and were assessed for antibiotic susceptibility, cyclic di-GMP levels, biofilm production, motility and genetic-relatedness...
October 16, 2017: Microbiology
https://www.readbyqxmd.com/read/29033388/how-should-i-treat-an-iatrogenic-type-iia-debakey-stanford-aortic-dissection-during-a-percutaneous-right-coronary-artery-intervention
#5
Claudiu Stoicescu, Dragos Vinereanu, Ismail Dogu Kilic, Muharrem Nasifov, Omer Goktekin, Fadi Sawaya, Oscar Millan-Iturbe, Lars Søndergaard
No abstract text is available yet for this article.
October 13, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29025490/defining-the-research-agenda-to-measure-and-reduce-tuberculosis-stigmas
#6
K Macintyre, M I Bakker, S Bergson, R Bhavaraju, V Bond, J Chikovore, C Colvin, G M Craig, A L Cremers, A Daftary, N Engel, N Ferris France, E Jaramillo, M Kimerling, A Kipp, S Krishnaratne, C Mergenthaler, M Ngicho, L Redwood, E J J Rood, N Sommerland, A Stangl, A van Rie, W van Brakel, E Wouters, A Zwerling, E M H Mitchell
Crucial to finding and treating the 4 million tuberculosis (TB) patients currently missed by national TB programmes, TB stigma is receiving well-deserved and long-delayed attention at the global level. However, the ability to measure and evaluate the success of TB stigma-reduction efforts is limited by the need for additional tools. At a 2016 TB stigma-measurement meeting held in The Hague, The Netherlands, stigma experts discussed and proposed a research agenda around four themes: 1) drivers: what are the main drivers and domains of TB stigma(s)?; 2) consequences: how consequential are TB stigmas and how are negative impacts most felt?; 3) burden: what is the global prevalence and distribution of TB stigma(s) and what explains any variation? 4): intervention: what can be done to reduce the extent and impact of TB stigma(s)? Each theme was further subdivided into research topics to be addressed to move the agenda forward...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29025392/co-founding-ant-queens-prevent-disease-by-performing-prophylactic-undertaking-behaviour
#7
Christopher D Pull, Sylvia Cremer
BACKGROUND: Social insects form densely crowded societies in environments with high pathogen loads, but have evolved collective defences that mitigate the impact of disease. However, colony-founding queens lack this protection and suffer high rates of mortality. The impact of pathogens may be exacerbated in species where queens found colonies together, as healthy individuals may contract pathogens from infectious co-founders. Therefore, we tested whether ant queens avoid founding colonies with pathogen-exposed conspecifics and how they might limit disease transmission from infectious individuals...
October 13, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29016703/%C3%AE-arrestin-2-mediates-cardiac-ischemia-reperfusion-injury-via-inhibiting-gpcr-independent-cell-survival-signalling
#8
Yimei Wang, Li Jin, Ying Song, Mao Zhang, Dan Shan, Yuli Liu, Meng Fang, Fengxiang Lv, Rui-Ping Xiao, Yan Zhang
Aims: Ischemic heart disease is a leading cause of morbidity and mortality worldwide. Although timely restoration of coronary blood flow (reperfusion) is the most effective therapeutics of myocardial infarction, reperfusion causes further cardiac damage, i.e. ischemia-reperfusion (I/R) injury. β-arrestins (Arrbs) have been traditionally defined as negative regulators of G protein-coupled receptor (GPCR) signalling, but recent studies have shown that they are essential for G protein-independent, GPCR-mediated biased signalling...
August 4, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28990333/a-truly-complementary-approach-a-qualitative-exploration-of-complementary-and-alternative-medicine-practitioners-views-of-treating-ankylosing-spondylitis
#9
Hannah Family, Abbie Jordan, Kelly Blaxall, Raj Sengupta
OBJECTIVE: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease in which individuals experience a long delay to diagnosis. Prior to diagnosis, individuals report frequent use of complementary and alternative medicine (CAM) therapies. While popularly used, there is a dearth of knowledge concerning the experiences of CAM practitioners in terms of treating individuals with AS. Addressing this knowledge gap, the present study provides a detailed exploration of how UK-based CAM practitioners treat individuals with AS...
October 9, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28990127/patterns-of-axillary-evaluation-in-older-patients-with-breast-cancer-and-associations-with-adjuvant-therapy-receipt
#10
Laura S Dominici, Helmneh M Sineshaw, Ahmedin Jemal, Chun Chieh Lin, Tari A King, Rachel A Freedman
PURPOSE: Although axillary lymph node status has traditionally been a key factor in informing adjuvant breast cancer therapy recommendations, this information may be less relevant as our focus shifts more towards tumor biology, particularly in older patients where comorbidity influences treatment decisions and nodal staging and/or surgery may not improve outcomes. We examined patterns of axillary surgery and associations between axillary surgery and receipt of adjuvant treatment in older breast cancer patients...
October 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28986096/high-fat-diet-enhances-hepatic-ischemia-reperfusion-injury-induced-apoptosis-role-of-glucocorticoid-receptors
#11
Huan-Qiu Liu, Rui-Jun Li, Xin Sun, Ji Li
AIMS: The present study was designed to evaluate whether and how glucocorticoids can affect obesity-regulated hepatic ischemia-reperfusion (I/R) injury. MAIN METHODS: To this end, we first examined whether hydrocortisone (HCT) has protective effects on liver damage induced by hepatic I/R injury in mice receiving high fat diet treatment. We then explored the role of GR expression and phosphorylation in the anti-apoptotic effects of hydrocortisone upon hepatic I/R injury...
October 3, 2017: Life Sciences
https://www.readbyqxmd.com/read/28983021/sayani-fa-abrams-cs-how-i-treat-refractory-thrombotic-thrombocytopenic-purpura-blood-2015-125-25-3860-3867
#12
(no author information available yet)
No abstract text is available yet for this article.
October 5, 2017: Blood
https://www.readbyqxmd.com/read/28982143/ifn-%C3%AE-alters-the-expression-of-diverse-immunity-related-genes-in-a-cell-culture-model-designed-to-represent-maturing-neutrophils
#13
Michael A Ellison, Christy M Gearheart, Christopher C Porter, Daniel R Ambruso
The cytokine interferon-γ (IFN-γ) is approved as a drug to treat chronic granulomatous disease (CGD) and osteopetrosis and is also used in hyperimmunoglobulin E syndromes. Patients with CGD have defects in proteins of the NOX2 NADPH oxidase system. This leads to reduced production of microbicidal ROS by PMNs and recurrent life threatening infections. The goal of this study was to better understand how IFN-γ might support phagocyte function in these diseases, and to obtain information that might expand potential uses for IFN-γ...
2017: PloS One
https://www.readbyqxmd.com/read/28981095/rtn1-c-mediates-cerebral-ischemia-reperfusion-injury-via-er-stress-and-mitochondria-associated-apoptosis-pathways
#14
Lingli Gong, Yuewen Tang, Ran An, Muya Lin, Lijian Chen, Jian Du
The reticulon family has been found to induce apoptosis, inhibit axon regeneration and regulate protein trafficking. However, little is known about the mechanisms of how reticulon proteins are involved in neuronal death-promoting processes during ischemia. Here, we report that the expression of Reticulon Protein 1-C (RTN1-C) was associated with the progression of cerebral ischemia/reperfusion (I/R) injury. Using a combination of rat middle cerebral artery occlusion (MCAO) stroke and oxygen-glucose deprivation followed by reoxygenation (OGD/R) models, we determined that the expression of RTN1-C was significantly increased during cerebral ischemic/reperfusion...
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28978095/melphalan-modifies-the-bone-microenvironment-by-enhancing-osteoclast-formation
#15
Ryan C Chai, Michelle M McDonald, Rachael L Terry, Nataša Kovačić, Jenny M Down, Jessica A Pettitt, Sindhu T Mohanty, Shruti Shah, Gholamreza Haffari, Jiake Xu, Matthew T Gillespie, Michael J Rogers, John T Price, Peter I Croucher, Julian M W Quinn
Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor development. Dormant MM cells can be reactivated after melphalan treatment; however, it is unclear whether melphalan treatment increases osteoclast formation to modify the endosteal niche. Melphalan treatment of mice for 14 days decreased bone volume and the endosteal bone surface, and this was associated with increases in osteoclast numbers...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977687/professional-structural-and-organisational-interventions-in-primary-care-for-reducing-medication-errors
#16
REVIEW
Hanan Khalil, Brian Bell, Helen Chambers, Aziz Sheikh, Anthony J Avery
BACKGROUND: Medication-related adverse events in primary care represent an important cause of hospital admissions and mortality. Adverse events could result from people experiencing adverse drug reactions (not usually preventable) or could be due to medication errors (usually preventable). OBJECTIVES: To determine the effectiveness of professional, organisational and structural interventions compared to standard care to reduce preventable medication errors by primary healthcare professionals that lead to hospital admissions, emergency department visits, and mortality in adults...
October 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28968456/lack-of-knowledge-and-availability-of-diagnostic-equipment-could-hinder-the-diagnosis-of-sarcopenia-and-its-management
#17
Esmee M Reijnierse, Marian A E de van der Schueren, Marijke C Trappenburg, Marjan Doves, Carel G M Meskers, Andrea B Maier
OBJECTIVES: Sarcopenia is an emerging clinical challenge in an ageing population and is associated with serious negative health outcomes. This study aimed to assess the current state of the art regarding the knowledge about the concept of sarcopenia and practice of the diagnostic strategy and management of sarcopenia in a cohort of Dutch healthcare professionals (physicians, physiotherapists, dietitians and others) attending a lecture cycle on sarcopenia. MATERIAL AND METHODS: This longitudinal study included Dutch healthcare professionals (n = 223) who were asked to complete a questionnaire before, directly after and five months after (n = 80) attending a lecture cycle on the pathophysiology of sarcopenia, diagnostic strategy and management of sarcopenia, i...
2017: PloS One
https://www.readbyqxmd.com/read/28964519/inhibiting-prolactin-by-cabergoline-accelerates-mammary-gland-remodeling-during-the-early-dry-period-in-dairy-cows
#18
M Boutinaud, N Isaka, E Gandemer, P Lamberton, S Wiart, A I De Prado Taranilla, L M Sordillo, V Lollivier
The inhibition of prolactin release using cabergoline, a dopamine agonist, is an effective strategy to accelerate the changes in mammary secretion composition after drying-off. The objective of this study was to determine how cabergoline may affect mammary tissue remodeling during early involution. Holstein dairy cows were treated with either a single i.m. administration of 5.6 mg of cabergoline (Velactis, Ceva Santé Animale, Libourne, France, n = 7) or placebo (n = 7) at the time of drying-off. Mammary biopsy samples were collected 1 wk before drying-off (d -6), after 30 h of milk accumulation (d 1), and again 8 d following drying-off (d 8) to determine changes in gene expression, lactoferrin content, and cell turnover...
September 27, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28962190/metformin-in-combination-with-rosiglitazone-contribute-to-the-increased-serum-adiponectin-levels-in-people-with-type-2-diabetes-mellitus
#19
Jie-Ming Nie, Hai-Feng Li
To evaluate how metformin plus rosiglitazone affect serum adiponectin levels in people suffering from type 2 diabetes mellitus (T2DM), 240 patients having T2DM were selected in this cohort study. Included subjects were randomly and equally separated into three subsets: i) Group A (rosiglitazone group); ii) group B (metformin group); and iii) group C (rosiglitazone + metformin group). Furthermore, meta-analysis of previous studies was performed by searching the general search engines and bibliographic databases...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28955319/how-to-feed-the-mammalian-gut-microbiota-bacterial-and-metabolic-modulation-by-dietary-fibers
#20
Chiara Ferrario, Rosario Statello, Luca Carnevali, Leonardo Mancabelli, Christian Milani, Marta Mangifesta, Sabrina Duranti, Gabriele A Lugli, Beatriz Jimenez, Samantha Lodge, Alice Viappiani, Giulia Alessandri, Margerita Dall'Asta, Daniele Del Rio, Andrea Sgoifo, Douwe van Sinderen, Marco Ventura, Francesca Turroni
The composition of the gut microbiota of mammals is greatly influenced by diet. Therefore, evaluation of different food ingredients that may promote changes in the gut microbiota composition is an attractive approach to treat microbiota disturbances. In this study, three dietary fibers, such as inulin (I, 10%), resistant starch (RS, 10%), and citrus pectin (3%), were employed as supplements to normal chow diet of adult male rats for 2 weeks. Fecal microbiota composition and corresponding metabolite profiles were assessed before and after prebiotics supplementation...
2017: Frontiers in Microbiology
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