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https://www.readbyqxmd.com/read/29662485/our-environment-shapes-us-the-importance-of-environment-and-sex-differences-in-regulation-of-autoantibody-production
#1
REVIEW
Michael Edwards, Rujuan Dai, S Ansar Ahmed
Consequential differences exist between the male and female immune systems' ability to respond to pathogens, environmental insults or self-antigens, and subsequent effects on immunoregulation. In general, females when compared with their male counterparts, respond to pathogenic stimuli and vaccines more robustly, with heightened production of antibodies, pro-inflammatory cytokines, and chemokines. While the precise reasons for sex differences in immune response to different stimuli are not yet well understood, females are more resistant to infectious diseases and much more likely to develop autoimmune diseases...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29659476/prospective-evaluation-of-low-health-literacy-and-its-impact-on-outcomes-in-trauma-patients
#2
Tianyi Swartz, Faisal Jehan, Andrew Tang, Lynn Gries, Muhammad Zeeshan, Narong Kulvatunyou, Mohammad Hamidi, Terence O'Keeffe, Bellal Joseph
INTRODUCTION: Health-literacy is emerging focus of interest in public health and is evolving as an important component of national health policy. Low-health-literacy (LHL) is associated with poor outcomes. We aimed to identify factors associated with LHL and its relationship with health outcomes in trauma patients. METHODS: We prospectively enrolled all adult trauma patients (age>18y) in our analysis. Patients were surveyed at discharge and followed up at 4-weeks post-discharge...
April 13, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29653141/dual-mechanism-of-type-vii-collagen-transfer-by-bone-marrow-mesenchymal-stem-cell-extracellular-vesicles-to-recessive-dystrophic-epidermolysis-bullosa-fibroblasts
#3
Jeffrey McBride, Luis Rodriguez-Menocal, Ambar Candanedo, Wellington Guzman, Marta Garcia-Contreras, Evangelos Badiavas
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease resulting from a lack of type VII collagen production. Recent clinical trials have shown efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the treatment of epidermolysis bullosa, including improved basement membrane restructuring and cutaneous wound healing. The mechanism as to how type VII collagen is transferred from donor stem cell to recipient RDEB cells has not been defined. Here, we submit the model that BM-MSC-derived extracellular vesicles serve at least two roles: 1) to help transport type VII collagen within the extracellular space; and 2) to feed RDEB fibroblasts with messenger RNA that codes for type VII collagen, resulting in COL7A1 translation and synthesis of type VII collagen alpha chain proteins by RDEB fibroblasts...
April 10, 2018: Biochimie
https://www.readbyqxmd.com/read/29651507/efficacy-and-side-effects-of-baclofen-and-the-novel-gaba-b-receptor-positive-allosteric-modulator-cmppe-in-animal-models-for-alcohol-and-cocaine-addiction
#4
Valentina Vengeliene, Tatiane T Takahashi, Olga A Dravolina, Irina Belozertseva, Edwin Zvartau, Anton Y Bespalov, Rainer Spanagel
RATIONALE: Preclinical studies suggest that the GABAB receptor is a potential target for treatment of substance use disorders. However, recent clinical trials report adverse effects in patients treated with the GABAB receptor agonist baclofen and even question efficacy. How can the discrepancy between preclinical and clinical findings be explained? OBJECTIVE: To test efficacy and adverse effects of baclofen and the novel GABAB positive allosteric modulator (PAM) CMPPE in rat addiction models, which were developed in accordance with DSM...
April 12, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29630051/flow-cytometry-to-estimate-leukemia-stem-cells-in-primary-acute-myeloid-leukemia-and-in-patient-derived-xenografts-at-diagnosis-and-follow-up
#5
Thomas Boyer, Fanny Gonzales, Adriana Plesa, Pauline Peyrouze, Adeline Barthelemy, Soizic Guihard, Bruno Quesnel, Christophe Roumier, Claude Preudhomme, Meyling Cheok
Acute myeloid leukemia (AML) is a heterogeneous, and if not treated, fatal disease. It is the most common cause of leukemia-associated mortality in adults. Initially, AML is a disease of hematopoietic stem cells (HSC) characterized by arrest of differentiation, subsequent accumulation of leukemia blast cells, and reduced production of functional hematopoietic elements. Heterogeneity extends to the presence of leukemia stem cells (LSC), with this dynamic cell compartment evolving to overcome various selection pressures imposed upon during leukemia progression and treatment...
March 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29629608/intravenous-pulses-of-methylprednisolone-to-treat-flares-of-immune-mediated-diseases-how-much-how-long
#6
A Danza, I Borgia, J I Narváez, A Baccelli, C Amigo, M Rebella, V Domínguez
Introduction Glucocorticoids are widely used in the treatment of immune-mediated diseases. Despite their widespread use, details on dosing, effectiveness and adverse effects are yet to be determined. Objective To know the current use of methylprednisolone (MTP) in the management of immune-mediated conditions, evaluating the relationship among doses, therapeutic response and adverse effects. Methodology A multicenter retrospective cohort study was designed, including patients who received intravenous pulses of MTP between 1 January 2013 and 12 December 2015 in three different hospitals in Uruguay...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29627547/implementation-of-uv-based-advanced-oxidation-processes-in-algal-medium-recycling
#7
Wenxuan Wang, Jun Sha, Zhiying Lu, Senlin Shao, Peizhe Sun, Qiang Hu, Xuezhi Zhang
Algae show great potential as sustainable feedstock for numerous bioproducts. However, large volume of water consumption during algal biomass production makes that the culture media recycling is a necessity due to economic and environmental concern. To avoid the negative effect of enriched organic matters in the harvested culture media, pre-treatment prior to medium replenishment and reuse is required. In this study, degradation of algenitic organic matters (AOM) in the culture media by UV-based photolysis processes (i...
April 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29625790/transfusion-associated-hazards-a-revisit-of-their-presentation
#8
O Garraud, C Sut, A Haddad, S Tariket, C Aloui, S Laradi, H Hamzeh-Cognasse, T Bourlet, F Zeni, C Aubron, Y Ozier, S Laperche, T Peyrard, P Buffet, D Guyotat, E Tavernier, F Cognasse, B Pozzetto, G Andreu
As a therapy or a support to other therapies, despite being largely beneficial to patients in general, transfusion it is not devoid of some risks. In a moderate number of cases, patients may manifest adverse reactions, otherwise referred to as transfusion-associated hazards (TAHs). The latest French 2016 haemovigilance report indicates that 93% of TAHs are minor (grade 1), 5.5% are moderate (grade 2) and 1.6% are severe (grade 3), with only five deaths (grade 4) being attributed to transfusion with relative certainty (imputability of level [or grade] 1 to 3)...
April 3, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29624644/producing-internal-suspect-bodies-divisive-effects-of-uk-counter-terrorism-measures-on-muslim-communities-in-leeds-and-bradford
#9
Madeline-Sophie Abbas
Research on UK government counter-terrorism measures has claimed that Muslims are treated as a 'suspect community'. However, there is limited research exploring the divisive effects that membership of a 'suspect community' has on relations within Muslim communities. Drawing from interviews with British Muslims living in Leeds or Bradford, I address this gap by explicating how co-option of Muslim community members to counter extremism fractures relations within Muslim communities. I reveal how community members internalize fears of state targeting which precipitates internal disciplinary measures...
April 6, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29619274/evaluating-postoperative-complications-and-outcomes-of-orthopedic-fracture-repair-in-nonagenarian-patients
#10
Kyle A Scarano, Frances H Philp, Edward R Westrick, Gregory T Altman, Daniel T Altman
Introduction: The United States and the world are currently experiencing a tremendous growth in the elderly population. Moreover, individuals surpassing the ages of 80 and 90 are also continuing to increase. As this unique division of society expands, it is critical that the medical community best understands how to assess, diagnose, and treat this population. The purpose of this study was to analyze morbidity, mortality, and overall outcome of patients aged 90 years and older after orthopedic surgical fracture repair...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29616022/temporal-regulation-of-natural-killer-t-cell-interferon-gamma-responses-by-%C3%AE-catenin-dependent-and-independent-wnt-signaling
#11
Jessica C Kling, Margaret A Jordan, Lauren A Pitt, Jana Meiners, Thao Thanh-Tran, Le Son Tran, Tam T K Nguyen, Deepak Mittal, Rehan Villani, Raymond J Steptoe, Kiarash Khosrotehrani, Stuart P Berzins, Alan G Baxter, Dale I Godfrey, Antje Blumenthal
Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity. Interferon gamma (IFN-γ) and IL-4 are key cytokines rapidly produced by NKT cells upon recognition of glycolipid antigens presented by antigen-presenting cells (APCs). It has previously been reported that the transcriptional coactivator β-catenin regulates NKT cell differentiation and functionally biases NKT cell responses toward IL-4, at the expense of IFN-γ production...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29614987/the-silent-burden-of-stigmatisation-a-qualitative-study-among-dutch-people-with-a-low-socioeconomic-position
#12
Audrey M W Simons, Inge Houkes, Annemarie Koster, Daniëlle A I Groffen, Hans Bosma
BACKGROUND: In-depth qualitative research into perceived socioeconomic position-related stigmatisation among people living at the lower end of our socioeconomic hierarchy is necessary for getting more insight in the possible downside of living in an increasingly meritocratic and individualistic society. METHODS: Seventeen interviews were conducted among a group of Dutch people with a low socioeconomic position to examine their experiences with stigmatisation, how they coped with it and what they perceived as consequences...
April 3, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29610010/high-rate-of-positive-cultures-in-patients-referred-with-antibiotic-spacers-as-part-of-2-stage-exchange
#13
Kevin I Perry, Robert C Sproul, Rafael J Sierra, Matthew P Abdel, Thomas K Fehring, Arlen D Hanssen
BACKGROUND: Two-stage exchange for periprosthetic joint infection (PJI) in total knee arthroplasty (TKA) remains the gold standard treatment in North America. Occasionally, patients with knee PJI are referred for definitive management after resection and antibiotic spacer placement. Currently, little literature exists to suggest how these patients should be managed. The purpose of this study is to report the clinical outcomes of these patients. METHODS: We retrospectively identified 54 patients (54 knees) from 2000 to 2012 treated for PJI with initial TKA resection and spacer placement performed somewhere other than the definitive treatment center...
February 21, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29607401/additional-flap-on-plastic-stents-for-improved-antimigration-effect-in-the-treatment-of-post-cholecystectomy-bile-leak
#14
Chang-Il Kwon, Mark A Gromski, Hyoung-Chul Oh, Jeffrey J Easler, Ihab I El Hajj, James Watkins, Evan L Fogel, Lee McHenry, Stuart Sherman, Glen A Lehman
Background and study aims:  In plastic stent insertion for treatment of post-cholecystectomy bile leak, stent migration may be more common due to the absence of a shelf to anchor the stent. We evaluated how adding a flap to straight plastic stents for this indication might influence the rate of stent migration when compared to use of conventional plastic stents. Patients and methods:  This is a retrospective study including patients referred for ERCP for treatment of post-cholecystectomy bile leak...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29605169/burnout-and-posttraumatic-stress-in-paediatric-critical-care-personnel-prediction-from-resilience-and-coping-styles
#15
Rocío Rodríguez-Rey, Alba Palacios, Jesús Alonso-Tapia, Elena Pérez, Elena Álvarez, Ana Coca, Santiago Mencía, Ana Marcos, Juan Mayordomo-Colunga, Francisco Fernández, Fernando Gómez, Jaime Cruz, Olga Ordóñez, Ana Llorente
INTRODUCTION: Our aims were (1) to explore the prevalence of burnout syndrome (BOS) and posttraumatic stress disorder (PTSD) in a sample of Spanish staff working in the paediatric intensive care unit (PICU) and compare these rates with a sample of general paediatric staff and (2) to explore how resilience, coping strategies, and professional and demographic variables influence BOS and PTSD. MATERIALS AND METHODS: This is a multicentre, cross-sectional study. Data were collected in the PICU and in other paediatric wards of nine hospitals...
March 28, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29603681/a-comparative-cfd-study-of-four-inferior-vena-cava-filters
#16
Josep M López, Gerard Fortuny, Dolors Puigjaner, Joan Herrero, Francesc Marimon
Computational fluid dynamics was used to simulate the flow of blood within an inferior vena cava (IVC) geometry model that was reconstructed from computed tomography images obtained from a real patient. The main novelty of the present work is that we simulated the implantation of four different filter models in this realistic IVC geometry. We considered different blood flow rates in the range between Vin =20 and Vin =80cm3 /s and all simulations were performed with both the Newtonian and a non-Newtonian model for the blood viscosity...
March 30, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29599174/an-update-on-the-adjunctive-neurovascular-support-of-wide-neck-aneurysm-embolization-and-reconstruction-trial-1-year-safety-and-angiographic-results
#17
A M Spiotta, M I Chaudry, R D Turner, A S Turk, C P Derdeyn, J Mocco, S Tateshima
BACKGROUND AND PURPOSE: The safety and efficacy of the PulseRider for the treatment of wide-neck, bifurcation aneurysms at the basilar and carotid terminus locations were studied in a prospective trial, the Adjunctive Neurovascular Support of Wide-Neck Aneurysm Embolization and Reconstruction (ANSWER) trial, reporting on initial 6-month angiographic and clinical results. This report provides insight into the longer term durability and safety with 12-month data. MATERIALS AND METHODS: Aneurysms treated with the PulseRider among enrolled sites were prospectively studied...
March 29, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29599096/antithrombotic-therapy-trends-in-non-valvular-atrial-fibrillation-patients-undergoing-percutaneous-coronary-stent-implantation-results-from-a-survey-among-fellows-at-the-japanese-college-of-cardiology
#18
Daisuke Fukamachi, Atsushi Hirayama, Katsumi Miyauchi, Satoshi Yasuda, Hisao Ogawa, Hiroshi Ito, Hiroyuki Daida
BACKGROUND: Antithrombotic therapy with oral anticoagulants (OAC) in patients with atrial fibrillation (AF) after stent implantation, where dual antiplatelet therapy (DAPT) is also recommended, is not established. Antithrombotic therapies prescribed vary widely among cardiologists and may change year by year, according to the accumulation of new evidence. METHODS: A questionnaire-based survey concerning the antithrombotic therapy prescribed for OAC-treated AF patients who underwent stent implantation was conducted from 2014 to 2016...
March 26, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29590422/veteran-experiences-seeking-non-pharmacologic-approaches-for-pain
#19
Karleen Giannitrapani, Matthew McCaa, Marie Haverfield, Robert D Kerns, Christine Timko, Steven Dobscha, Karl Lorenz
Introduction: Pain is a longstanding and growing concern among US military veterans. Although many individuals rely on medications, a growing body of literature supports the use of complementary non-pharmacologic approaches when treating pain. Our objective is to characterize veteran experiences with and barriers to accessing alternatives to medication (e.g., non-pharmacologic treatments or non-pharmacologic approaches) for pain in primary care. Materials and Methods: Data for this qualitative analysis were collected as part of the Effective Screening for Pain (ESP) study (2012-2017), a national randomized controlled trial of pain screening and assessment methods...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29582358/follow-up-after-surgery-for-gastric-cancer-how-to-do-it
#20
Daniela Zanotti, Gian Luca Baiocchi, Arianna Coniglio, Borzoueh Mohammadi, Silvia Ministrini, Muntzer Mughal, Guido A M Tiberio, Khaled Dawas
There is no consensus on follow-up after gastric surgery for cancer, nor evidence that it improves outcomes. We investigated the impact of intensity of follow-up, comparing the regimens adopted by two centres, in Italy and in the UK. Patients who underwent surgery for gastric and junctional type-3 adenocarcinoma, between September 2009 and April 2013, at the Surgical Clinic, University of Brescia (Italy), and at the Department of Upper Gastrointestinal Surgery, University College London Hospital (UK), were identified...
March 26, 2018: Updates in Surgery
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