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https://www.readbyqxmd.com/read/29777071/an-epic-challenge-for-some-worthy-causes
#1
(no author information available yet)
Cal Major is attempting to travel from Lands End to John O'Groats on a stand up paddle board. Kathryn Clark finds out why.
May 19, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29762678/using-statistical-anomaly-detection-models-to-find-clinical-decision-support-malfunctions
#2
Soumi Ray, Dustin S McEvoy, Skye Aaron, Thu-Trang Hickman, Adam Wright
Objective: Malfunctions in Clinical Decision Support (CDS) systems occur due to a multitude of reasons, and often go unnoticed, leading to potentially poor outcomes. Our goal was to identify malfunctions within CDS systems. Methods: We evaluated 6 anomaly detection models: (1) Poisson Changepoint Model, (2) Autoregressive Integrated Moving Average (ARIMA) Model, (3) Hierarchical Divisive Changepoint (HDC) Model, (4) Bayesian Changepoint Model, (5) Seasonal Hybrid Extreme Studentized Deviate (SHESD) Model, and (6) E-Divisive with Median (EDM) Model and characterized their ability to find known anomalies...
May 11, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29761424/dietary-intake-of-total-polyphenol-and-polyphenol-classes-and-the-risk-of-colorectal-cancer-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-cohort
#3
Raul Zamora-Ros, Valerie Cayssials, Mazda Jenab, Joseph A Rothwell, Veronika Fedirko, Krasimira Aleksandrova, Anne Tjønneland, Cecilie Kyrø, Kim Overvad, Marie-Christine Boutron-Ruault, Franck Carbonnel, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Elissavet Valanou, Effie Vasilopoulou, Giovanna Masala, Valeria Pala, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Elisabete Weiderpass, Marko Lukic, Torkjel M Sandanger, Cristina Lasheras, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Carmen Navarro, Eva Ardanaz, Emily Sonestedt, Bodil Ohlsson, Lena Maria Nilsson, Martin Rutegård, Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Thee Khaw, Nicholas J Wareham, Kathryn Bradbury, Heinz Freisling, Isabelle Romieu, Amanda J Cross, Paolo Vineis, Augustin Scalbert
Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries...
May 15, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29761319/gaussian-graphical-models-identified-food-intake-networks-and-risk-of-type-2-diabetes-cvd-and-cancer-in-the-epic-potsdam-study
#4
Khalid Iqbal, Lukas Schwingshackl, Anna Floegel, Carolina Schwedhelm, Marta Stelmach-Mardas, Clemens Wittenbecher, Cecilia Galbete, Sven Knüppel, Matthias B Schulze, Heiner Boeing
PURPOSE: The aim of the study was to investigate the association between the previously identified Gaussian graphical models' (GGM) food intake networks and risk of major chronic diseases as well as intermediate biomarkers in the European Prospective Investigation into Cancer and nutrition (EPIC)-Potsdam cohort. METHODS: In this cohort analysis of 10,880 men and 13,340 women, adherence to the previously identified sex-specific GGM networks as well as principal component analysis identified patterns was investigated in relation to risk of major chronic diseases, using Cox-proportional hazard models...
May 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29759646/quantification-of-38-dietary-polyphenols-in-plasma-by-differential-isotope-labelling-and-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#5
David Achaintre, Audrey Gicquiau, Liang Li, Sabina Rinaldi, Augustin Scalbert
Polyphenols constitute one of the most complex classes of phytochemicals in the human diet and have been suggested to play a role in the prevention of chronic diseases such as cardiovascular diseases, diabetes and cancers. However, evidence from epidemiological studies is still needed to better understand their role in disease prevention. To do so, robust methods for the accurate measurement of these molecules in large series of samples are needed. We report here the development of a highly-sensitive method based on differential isotope labelling with 13 C- and 12 C-dansyl chloride for the analysis of 38 structurally diverse polyphenols in 50 μL plasma by tandem mass spectrometry with limits of quantification varying between 0...
May 9, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29748607/mir-455-3p-inhibits-the-degenerate-process-of-chondrogenic-differentiation-through-modification-of-dna-methylation
#6
Hao Sun, Xiaoyi Zhao, Chengyun Zhang, Ziji Zhang, Jiayong Lun, Weiming Liao, Zhiqi Zhang
The aim of this work was to determine whether miR-455-3p regulates DNA methylation during chondrogenic differentiation of hMSCs. The expression of miR-455-3p and de novo methyltransferase DNMT3A was assessed in micromass culture of hBMSCs, which induced chondrogenic differentiation in vitro, and in E16.5 mice in vivo. A luciferase reporter assay was used to confirm whether miR-455-3p directly targets DNMT3A by interaction with the 3'-UTR. Using an Illumina Infinium Methylation EPIC microarray, genome-wide DNA methylation of hBMSCs with or without overexpressed miR-455-3p was examined for 28 days during induced chondrogenic differentiation...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29746298/perinatally-acquired-hiv-infection-accelerates-epigenetic-aging-in-south-african-adolescents
#7
Steve Horvath, Nicole Phillips, Sarah J Heany, Michael S Kobor, David Ts Lin, Landon Myer, Heather J Zar, Dan J Stein, Andrew J Levine, Jacqueline Hoare
OBJECTIVE: Recent studies demonstrate that infection with the Human Immunodeficiency Virus-1 (HIV) is associated with accelerated aging effects in adults according to a highly accurate epigenetic biomarker of aging known as epigenetic clock. However, it not yet known whether epigenetic age acceleration occurs as early as adolescence in perinatally HIV-infected (PHIV+) youth. DESIGN: Observational study of PHIV and HIV-uninfected adolescents enrolled in the Cape Town Adolescent Antiretroviral Cohort (CTAAC) Study...
May 8, 2018: AIDS
https://www.readbyqxmd.com/read/29732447/high-resolution-adhesion-kinetics-of-egcg-exposed-tumor-cells-on-biomimetic-interfaces-comparative-monitoring-of-cell-viability-using-label-free-biosensor-and-classic-end-point-assays
#8
Beatrix Peter, Rita Ungai-Salanki, Bálint Szabó, Agoston G Nagy, Inna Szekacs, Szilvia Bősze, Robert Horvath
A high-throughput label-free resonant waveguide grating biosensor, the Epic BenchTop, was utilized to in situ monitor the adhesion process of cancer cells on Arg-Gly-Asp tripeptide displaying biomimetic polymer surfaces. Using highly adherent human cervical adenocarcinoma (HeLa) cells as a model system, cell adhesion kinetic data with outstanding temporal resolution were obtained. We found that pre-exposing the cells to various concentrations of the main extract of green tea, the (-)-epigallocatechin gallate (EGCG), largely affected the temporal evolution of the adhesion process...
April 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/29717489/influence-of-a-cancer-diagnosis-on-changes-in-fruit-and-vegetable-consumption-according-to-cancer-site-stage-at-diagnosis-and-socioeconomic-factors-results-from-the-large-e3n-epic-study
#9
Aurélie Affret, Mathilde His, Gianluca Severi, Francesca Romana Mancini, Patrick Arveux, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Guy Fagherazzi
Many studies have demonstrated that lifestyle factors, including diet, may influence cancer survival. The number of cancer survivors is increasing worldwide and little is known about long-term diet changes in people who had cancer. We studied 53 981 women from the prospective E3N-EPIC cohort study with available dietary data in 1993 and 2005, among whom 4 619 had a cancer diagnosis inbetween (including n=2 699 breast cancers). We evaluated the potential impact of a cancer diagnosis (comparing women with cancer to women with no cancer) on changes in FV consumption using multivariable linear regression models considering cancer site, stage at diagnosis, and socioeconomic factors...
May 1, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29707771/nonsteroidal-anti-inflammatory-drug-use-and-breast-cancer-risk-in-a-european-prospective-cohort-study
#10
Manon Cairat, Agnès Fournier, Neil Murphy, Carine Biessy, Augustin Scalbert, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Patrick Arveux, Marie-Christine Boutron-Ruault, Claire Cadeau, Renée Turzanski Fortner, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Petra H M Peeters, Carla H Van Gils, Nicholas J Wareham, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Marc J Gunter, Laure Dossus
Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to assess the association between NSAID use and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Self-reported information on NSAID use at baseline has been collected in five EPIC countries...
April 29, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29699034/-association-between-obesity-and-dna-methylation-among-the-7-16-year-old-twins
#11
C X Li, Y Gao, W J Gao, C Q Yu, J Lyu, R R Lyu, J L Duan, Y Sun, X H Guo, S F Wang, B Zhou, G Wang, W H Cao, L M Li
Objective: On whole-genome scale, we tried to explore the correlation between obesity-related traits and DNA methylation sites, based on discordant monozygotic twin pairs. Methods: A total of 90 pairs of 6-17 year-old twins were recruited in Chaoyang district, Yanqing district and Fangshan district in Beijing in 2016. Information on twins was gathered through a self-designed questionnaire and results: from physical examination, including height, weight and waist circumference of the subjects under study. DNA methylation detection was chosen on the Illumina Human Methylation EPIC BeadChip...
April 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29696479/natural-language-processing-accurately-calculates-adenoma-and-sessile-serrated-polyp-detection-rates
#12
Jennifer Nayor, Lawrence F Borges, Sergey Goryachev, Vivian S Gainer, John R Saltzman
BACKGROUND: ADR is a widely used colonoscopy quality indicator. Calculation of ADR is labor-intensive and cumbersome using current electronic medical databases. Natural language processing (NLP) is a method used to extract meaning from unstructured or free text data. AIMS: (1) To develop and validate an accurate automated process for calculation of adenoma detection rate (ADR) and serrated polyp detection rate (SDR) on data stored in widely used electronic health record systems, specifically Epic electronic health record system, Provation® endoscopy reporting system, and Sunquest PowerPath pathology reporting system...
April 26, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29695712/adherence-to-a-mediterranean-diet-and-long-term-changes-in-weight-and-waist-circumference-in-the-epic-italy-cohort
#13
Claudia Agnoli, Sabina Sieri, Fulvio Ricceri, Maria Teresa Giraudo, Giovanna Masala, Melania Assedi, Salvatore Panico, Amalia Mattiello, Rosario Tumino, Maria Concetta Giurdanella, Vittorio Krogh
Excessive calorie intake and physical inactivity are considered key determinants of the rapid worldwide increase in obesity prevalence, however the relationship between diet and weight gain is complex. We investigated associations between adherence to a Mediterranean diet and long-term changes in weight and waist circumference in volunteers recruited to the Italian section of the prospective European Prospective Investigation into Cancer and Nutrition (EPIC). We investigated 32,119 cohort members who provided anthropometric measures at recruitment and updated information on recall a mean of 12 years later...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29688461/transition-to-a-new-electronic-health-record-and-pediatric-medication-safety-lessons-learned-in-pediatrics-within-a-large-academic-health-system
#14
Kimberly Whalen, Emily Lynch, Iman Moawad, Tanya John, Denise Lozowski, Brian M Cummings
Objective: While the electronic health record (EHR) has become a standard of care, pediatric patients pose a unique set of risks in adult-oriented systems. We describe medication safety and implementation challenges and solutions in the pediatric population of a large academic center transitioning its EHR to Epic. Methods: Examination of the roll-out of a new EHR in a mixed neonatal, pediatric and adult tertiary care center with staggered implementation. We followed the voluntarily reported medication error rate for the neonatal and pediatric subsets and specifically monitored the first 3 months after the roll-out of the new EHR...
April 23, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29682493/the-frequency-of-clinic-visits-was-not-associated-with-medication-adherence-or-outcome-in-children-with-inflammatory-bowel-diseases
#15
Cheryl Kluthe, Jenkin Tsui, Donald Spady, Matthew Carroll, Eytan Wine, Hien Quoc Huynh
Background: Medication nonadherence is a challenge in pediatric patients with inflammatory bowel diseases (IBD). Poor adherence can result in disease flare-ups, disease complicationstherapy escalation, and the need for corticosteroids. The aim was to determine if clinic visit frequency was associated with treatment adherence. Methods: A retrospective chart review of patients attending the Edmonton Pediatric IBD Clinic (EPIC) at the Stollery Children's Hospital from January 2012 to December 2013 was completed...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29676281/risk-thresholds-for-alcohol-consumption-combined-analysis-of-individual-participant-data-for-599-912-current-drinkers-in-83-prospective-studies
#16
Angela M Wood, Stephen Kaptoge, Adam S Butterworth, Peter Willeit, Samantha Warnakula, Thomas Bolton, Ellie Paige, Dirk S Paul, Michael Sweeting, Stephen Burgess, Steven Bell, William Astle, David Stevens, Albert Koulman, Randi M Selmer, W M Monique Verschuren, Shinichi Sato, Inger Njølstad, Mark Woodward, Veikko Salomaa, Børge G Nordestgaard, Bu B Yeap, Astrid Fletcher, Olle Melander, Lewis H Kuller, Beverley Balkau, Michael Marmot, Wolfgang Koenig, Edoardo Casiglia, Cyrus Cooper, Volker Arndt, Oscar H Franco, Patrik Wennberg, John Gallacher, Agustín Gómez de la Cámara, Henry Völzke, Christina C Dahm, Caroline E Dale, Manuela M Bergmann, Carlos J Crespo, Yvonne T van der Schouw, Rudolf Kaaks, Leon A Simons, Pagona Lagiou, Josje D Schoufour, Jolanda M A Boer, Timothy J Key, Beatriz Rodriguez, Conchi Moreno-Iribas, Karina W Davidson, James O Taylor, Carlotta Sacerdote, Robert B Wallace, J Ramon Quiros, Rosario Tumino, Dan G Blazer, Allan Linneberg, Makoto Daimon, Salvatore Panico, Barbara Howard, Guri Skeie, Timo Strandberg, Elisabete Weiderpass, Paul J Nietert, Bruce M Psaty, Daan Kromhout, Elena Salamanca-Fernandez, Stefan Kiechl, Harlan M Krumholz, Sara Grioni, Domenico Palli, José M Huerta, Jackie Price, Johan Sundström, Larraitz Arriola, Hisatomi Arima, Ruth C Travis, Demosthenes B Panagiotakos, Anna Karakatsani, Antonia Trichopoulou, Tilman Kühn, Diederick E Grobbee, Elizabeth Barrett-Connor, Natasja van Schoor, Heiner Boeing, Kim Overvad, Jussi Kauhanen, Nick Wareham, Claudia Langenberg, Nita Forouhi, Maria Wennberg, Jean-Pierre Després, Mary Cushman, Jackie A Cooper, Carlos J Rodriguez, Masaru Sakurai, Jonathan E Shaw, Matthew Knuiman, Trudy Voortman, Christa Meisinger, Anne Tjønneland, Hermann Brenner, Luigi Palmieri, Jean Dallongeville, Eric J Brunner, Gerd Assmann, Maurizio Trevisan, Richard F Gillum, Ian Ford, Naveed Sattar, Mariana Lazo, Simon G Thompson, Pietro Ferrari, David A Leon, George Davey Smith, Richard Peto, Rod Jackson, Emily Banks, Emanuele Di Angelantonio, John Danesh
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank)...
April 14, 2018: Lancet
https://www.readbyqxmd.com/read/29665866/mitochondrial-dna-copy-number-variation-leukocyte-telomere-length-and-breast-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-study
#17
Daniele Campa, Myrto Barrdahl, Aurelia Santoro, Gianluca Severi, Laura Baglietto, Hanane Omichessan, Rosario Tumino, H B As Bueno-de-Mesquita, Petra H Peeters, Elisabete Weiderpass, Maria-Dolores Chirlaque, Miguel Rodríguez-Barranco, Antonio Agudo, Marc Gunter, Laure Dossus, Vittorio Krogh, Giuseppe Matullo, Antonia Trichopoulou, Ruth C Travis, Federico Canzian, Rudolf Kaaks
BACKGROUND: Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC). METHODS: To gain a more comprehensive picture on how these markers can modulate BC risk, alone or in conjunction, we performed simultaneous measurements of LTL and mtDNA copy number in up to 570 BC cases and 538 controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
April 17, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29661801/anti-ca15-3-and-anti-ca125-antibodies-and-ovarian-cancer-risk-results-from-the-epic-cohort
#18
Daniel W Cramer, Raina N Fichorova, Kathryn L Terry, Hidemi S Yamamoto, Allison F Vitonis, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Jenny Brändstedt, Marie-Christine Boutron-Ruault, Maria-Dolores Chirlaque, Miren Dorronsoro, Laure Dossus, Eric J Duell, Inger T Gram, Marc J Gunter, Louise Hansen, Annika Idahl, Theron Johnson, Kay-Tee Khaw, Vittorio Korgh, Marina Kvaskoff, Amalia Mattiello, Giuseppe Matullo, Melissa A Merritt, Björn Nodin, N Charlotte Onland-Moret, Philippos Orfanos, Domenico Palli, Eleni Peppa, J Ramón Quirós, Maria-José Sànchez-Pérez, Gianluca Severi, Ruth C Travis, Antonia Trichopoulou, Rosario Tumino, Elisabete Weiderpass, Renée Turzanski Fortner, Rudolf Kaaks
BACKGROUND: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3 and CA125, and generate antibodies against them; but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined. METHODS: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression...
April 16, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29650484/identification-of-new-tools-to-predict-surgical-performance-of-novices-using-a-plastic-surgery-simulator
#19
Roy Kazan, Alex Viezel-Mathieu, Shantale Cyr, Thomas M Hemmerling, Samuel J Lin, Mirko S Gilardino
OBJECTIVE: To identify new tools capable of predicting surgical performance of novices on an augmentation mammoplasty simulator. The pace of technical skills acquisition varies between residents and may necessitate more time than that allotted by residency training before reaching competence. Identifying applicants with superior innate technical abilities might shorten learning curves and the time to reach competence. The objective of this study is to identify new tools that could predict surgical performance of novices on a mammoplasty simulator...
April 9, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29625136/surgical-management-of-adult-acquired-buried-penis-impact-on-urinary-and-sexual-quality-of-life-outcomes
#20
Katherine M Theisen, Thomas W Fuller, Paul Rusilko
OBJECTIVES: To assess postoperative patient-reported quality of life outcomes following surgical management of adult acquired buried penis (AABP). We hypothesize that surgical treatment of AABP results in improvements in urinary and sexual quality of life. METHODS: Patients that underwent surgical treatment of AABP were retrospectively identified. The Expanded Prostate Cancer Index (EPIC) questionnaire was completed at ≥ 3 months postoperatively, and completed retrospectively to define preoperative symptoms...
April 3, 2018: Urology
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