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https://www.readbyqxmd.com/read/28716665/applying-label-free-dynamic-mass-redistribution-assay-for-studying-endogenous-fpr1-receptor-signalling-in-human-neutrophils
#1
Hanna B Christensen, David E Gloriam, Daniel Sejer Pedersen, Jack B Cowland, Niels Borregaard, Hans Bräuner-Osborne
INTRODUCTION: The label-free dynamic mass redistribution-based assay (DMR) is a powerful method for studying signalling pathways of G protein-coupled receptors (GPCRs). Herein we present the label-free DMR assay as a robust readout for pharmacological characterization of formyl peptide receptors (FPRs) in human neutrophils. METHODS: Neutrophils were isolated from fresh human blood and their responses to FPR1 and FPR2 agonists, i.e. compound 43, fMLF and WKYMVm were measured in a label-free DMR assay using Epic Benchtop System from Corning®...
July 14, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28714975/association-analyses-based-on-false-discovery-rate-implicate-new-loci-for-coronary-artery-disease
#2
Christopher P Nelson, Anuj Goel, Adam S Butterworth, Stavroula Kanoni, Tom R Webb, Eirini Marouli, Lingyao Zeng, Ioanna Ntalla, Florence Y Lai, Jemma C Hopewell, Olga Giannakopoulou, Tao Jiang, Stephen E Hamby, Emanuele Di Angelantonio, Themistocles L Assimes, Erwin P Bottinger, John C Chambers, Robert Clarke, Colin N A Palmer, Richard M Cubbon, Patrick Ellinor, Raili Ermel, Evangelos Evangelou, Paul W Franks, Christopher Grace, Dongfeng Gu, Aroon D Hingorani, Joanna M M Howson, Erik Ingelsson, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Terho Lehtimäki, Xiangfeng Lu, Yingchang Lu, Winfried März, Ruth McPherson, Andres Metspalu, Mar Pujades-Rodriguez, Arno Ruusalepp, Eric E Schadt, Amand F Schmidt, Michael J Sweeting, Pierre A Zalloua, Kamal AlGhalayini, Bernard D Keavney, Jaspal S Kooner, Ruth J F Loos, Riyaz S Patel, Martin K Rutter, Maciej Tomaszewski, Ioanna Tzoulaki, Eleftheria Zeggini, Jeanette Erdmann, George Dedoussis, Johan L M Björkegren, Heribert Schunkert, Martin Farrall, John Danesh, Nilesh J Samani, Hugh Watkins, Panos Deloukas
Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10(-8)) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotype inclusive of angina (SOFT; ncases = 10,801) as well as a stricter definition without angina (HARD; ncases = 6,482) and selected cases with the former phenotype to conduct a meta-analysis using the two most recent CAD GWAS...
July 17, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28714111/room-for-improvement-in-breast-milk-feeding-after-very-preterm-birth-in-europe-results-from-the-epice-cohort
#3
Emilija Wilson, Anna-Karin Edstedt Bonamy, Mercedes Bonet, Liis Toome, Carina Rodrigues, Elizabeth A Howell, Marina Cuttini, Jennifer Zeitlin
Breast milk feeding (BMF) is associated with lower neonatal morbidity in the very preterm infant (<32 weeks gestation) and breastfeeding is beneficial for maternal health. Previous studies show large variations in BMF after very preterm birth and recognize the need for targeted breastfeeding support in the neonatal intensive care units (NICU). In a European collaboration project about evidence-based practices after very preterm birth, we examined the association between maternal, obstetric, and infant clinical factors; neonatal and maternal care unit policies; and BMF at discharge from the NICU...
July 17, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28713774/epic-immune-battles-of-history-neutrophils-vs-staphylococcus-aureus
#4
REVIEW
Fermin E Guerra, Timothy R Borgogna, Delisha M Patel, Eli W Sward, Jovanka M Voyich
Neutrophils are the most abundant leukocytes in human blood and the first line of defense after bacteria have breached the epithelial barriers. After migration to a site of infection, neutrophils engage and expose invading microorganisms to antimicrobial peptides and proteins, as well as reactive oxygen species, as part of their bactericidal arsenal. Ideally, neutrophils ingest bacteria to prevent damage to surrounding cells and tissues, kill invading microorganisms with antimicrobial mechanisms, undergo programmed cell death to minimize inflammation, and are cleared away by macrophages...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28710895/erectile-function-after-stereotactic-body-radiotherapy-for-localized-prostate-cancer
#5
Robert T Dess, Holly E Hartman, Nima Aghdam, William C Jackson, Payal D Soni, Ahmed E Abugharib, Simeng Suy, Neil B Desai, Zachary S Zumsteg, Rohit Mehra, Todd M Morgan, Felix Y Feng, Daniel A Hamstra, Matthew J Schipper, Sean P Collins, Daniel E Spratt
OBJECTIVE: To elucidate the functional erection rate following prostate stereotactic body radiotherapy (SBRT) and to develop a comprehensive prognostic model of outcomes following treatment. PATIENTS AND METHODS: Between 2008 and 2013, 373 consecutive men with localized prostate cancer were treated with SBRT at a single academic institution as part of a prospective clinical trial or prospective registry. Prospective longitudinal patient-reported quality of life (HRQOL) was collected using the Expanded Prostate Cancer Index Composite (EPIC-26)...
July 15, 2017: BJU International
https://www.readbyqxmd.com/read/28710438/simulation-of-long-term-yield-and-soil-water-consumption-in-apple-orchards-on-the-loess-plateau-china-in-response-to-fertilization
#6
Xingxing Peng, Zheng Guo, Yujiao Zhang, Jun Li
The Loess Plateau, China, is the world's largest apple-producing region, and over 80% of the orchards are in rainfed (dryland) areas. Desiccation of the deep soil layer under dryland apple orchards is the main stressor of apple production in this region. Fertilization is a factor that causes soil desiccation in dryland apple orchards. Given its applicability and precision validations, the Environmental Policy Integrated Climate (EPIC) model was used to simulate the dynamics of fruit yield and deep soil desiccation in apple orchards under six fertilization treatments...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701332/circulating-rankl-and-rankl-opg-and-breast-cancer-risk-by-er-and-pr-subtype-results-from-the-epic-cohort
#7
Danja Sarink, Helena Schock, Theron Johnson, Kim Overvad, Marianne Holm, Anne Tjonneland, Marie-Christine Boutron-Ruault, Mathilde His, Marina Kvaskoff, Heiner Boeing, Pagona Lagiou, Eleni-Maria Papatesta, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, H B As Bueno-de-Mesquita, Carla H van Gils, Petra H Peeters, Elisabete Weiderpass, Antonio Agudo, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Kay-Tee Khaw, Ruth C Travis, Laure Dossus, Marc J Gunter, Sabina Rinaldi, Melissa A Merritt, Elio Riboli, Rudolf Kaaks, Renee T Fortner
Receptor activator of nuclear factor kappa-B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoprotegerin (OPG), the decoy receptor for RANKL. sRANKL and breast cancer risk by hormone receptor subtype has not previously been investigated. <p>A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
July 12, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28701188/tall-height-and-obesity-are-associated-with-an-increased-risk-of-aggressive-prostate-cancer-results-from-the-epic-cohort-study
#8
Aurora Perez-Cornago, Paul N Appleby, Tobias Pischon, Konstantinos K Tsilidis, Anne Tjønneland, Anja Olsen, Kim Overvad, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Annika Steffen, Antonia Trichopoulou, Pagona Lagiou, Maria Kritikou, Vittorio Krogh, Domenico Palli, Carlotta Sacerdote, Rosario Tumino, H Bas Bueno-de-Mesquita, Antonio Agudo, Nerea Larrañaga, Elena Molina-Portillo, Aurelio Barricarte, Maria-Dolores Chirlaque, J Ramón Quirós, Pär Stattin, Christel Häggström, Nick Wareham, Kay-Tee Khaw, Julie A Schmidt, Marc Gunter, Heinz Freisling, Dagfinn Aune, Heather Ward, Elio Riboli, Timothy J Key, Ruth C Travis
BACKGROUND: The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours, but rather have assessed risk with a combined category of aggressive disease. We investigated the association of height and adiposity with incidence of and death from prostate cancer in 141,896 men in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
July 13, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28699840/distributed-improvisation-a-systems-perspective-of-improvisation-epics-by-led-outdoor-activity-leaders
#9
Margaret J Trotter, Paul M Salmon, Natassia Goode, Michael G Lenné
Improvisation represents the spontaneous and real-time conception and execution of a novel response to an unanticipated situation. In order to benefit from the positive safety potential of this phenomenon, it is necessary to understand what influences its appropriateness and effectiveness. This study has applied the system-based methodology Impromaps to analysing accounts of improvisation aimed at mitigating adverse safety outcomes. These accounts were obtained from led outdoor activity leaders through critical decision method interviews...
July 12, 2017: Ergonomics
https://www.readbyqxmd.com/read/28699252/mesenchymal-stromal-cell-derived-il-6-promotes-epithelial-mesenchymal-transition-and-acquisition-of-epithelial-stem-like-cell-properties-in-ameloblastoma-epithelial-cells
#10
Chunmiao Jiang, Qunzhou Zhang, Rabie M Shanti, Shihong Shi, Ting-Han Chang, Lee Carrasco, Faizan Alawi, Anh D Le
Epithelial-mesenchymal transition (EMT), a biological process associated with cancer stem-like or cancer-initiating cell (CSC) formation, contributes to the invasiveness, metastasis, drug resistance, and recurrence of the malignant tumors; it remains to be determined whether similar processes contribute to the pathogenesis and progression of ameloblastoma, a benign but locally invasive odontogenic neoplasm. Here, we demonstrated that EMT- and stem cell-related genes were expressed in the epithelial islands of the most common histologic variant subtype, the follicular ameloblastoma...
July 11, 2017: Stem Cells
https://www.readbyqxmd.com/read/28698291/bioprosthetic-valve-fracture-improves-the-hemodynamic-results-of-valve-in-valve-transcatheter-aortic-valve-replacement
#11
Adnan K Chhatriwalla, Keith B Allen, John T Saxon, David J Cohen, Sanjeev Aggarwal, Anthony J Hart, Suzanne J Baron, Danny Dvir, A Michael Borkon
BACKGROUND: Valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) may be less effective in small surgical valves because of patient/prosthesis mismatch. Bioprosthetic valve fracture (BVF) using a high-pressure balloon can be performed to facilitate VIV TAVR. METHODS AND RESULTS: We report data from 20 consecutive clinical cases in which BVF was successfully performed before or after VIV TAVR by inflation of a high-pressure balloon positioned across the valve ring during rapid ventricular pacing...
July 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28697562/the-montreal-cognitive-assessment-normative-data-from-a-large-swedish-population-based-cohort
#12
Emma Borland, Katarina Nägga, Peter M Nilsson, Lennart Minthon, Erik D Nilsson, Sebastian Palmqvist
BACKGROUND: The Montreal Cognitive Assessment (MoCA) is highly sensitivity for detecting cognitive dysfunction. Swedish normative data does not exist and international norms are often derived from populations where cognitive impairment has not been screened for and thoroughly assessed to exclude subjects with dementia or mild cognitive impairment. OBJECTIVE: To establish norms for MoCA and develop a regression-based norm calculator based on a large, well-examined cohort...
July 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28693547/longitudinal-associations-between-built-environment-characteristics-and-changes-in-active-commuting
#13
Lin Yang, Simon Griffin, Kay-Tee Khaw, Nick Wareham, Jenna Panter
BACKGROUND: Few studies have assessed the predictors of changes in commuting. This study investigated the associations between physical environmental characteristics and changes in active commuting. METHODS: Adults from the population-based European Prospective Investigation into Cancer (EPIC)-Norfolk cohort self-reported commuting patterns in 2000 and 2007. Active commuters were defined as those who reported 'always' or 'usually' walking or cycling to work. Environmental attributes around the home and route were assessed using Geographical Information Systems...
May 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28693038/coffee-drinking-and-mortality-in-10-european-countries-a-multinational-cohort-study
#14
Marc J Gunter, Neil Murphy, Amanda J Cross, Laure Dossus, Laureen Dartois, Guy Fagherazzi, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Krasimira Aleksandrova, Anne Tjønneland, Anja Olsen, Kim Overvad, Sofus Christian Larsen, Maria Luisa Redondo Cornejo, Antonio Agudo, María José Sánchez Pérez, Jone M Altzibar, Carmen Navarro, Eva Ardanaz, Kay-Tee Khaw, Adam Butterworth, Kathryn E Bradbury, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Sara Grioni, Paolo Vineis, Salvatore Panico, Rosario Tumino, Bas Bueno-de-Mesquita, Peter Siersema, Max Leenders, Joline W J Beulens, Cuno U Uiterwaal, Peter Wallström, Lena Maria Nilsson, Rikard Landberg, Elisabete Weiderpass, Guri Skeie, Tonje Braaten, Paul Brennan, Idlir Licaj, David C Muller, Rashmi Sinha, Nick Wareham, Elio Riboli
Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition)...
July 11, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28691708/an-exported-protein-interacting-complex-involved-in-the-trafficking-of-virulence-determinants-in-plasmodium-infected-erythrocytes
#15
Steven Batinovic, Emma McHugh, Scott A Chisholm, Kathryn Matthews, Boiyin Liu, Laure Dumont, Sarah C Charnaud, Molly Parkyn Schneider, Paul R Gilson, Tania F de Koning-Ward, Matthew W A Dixon, Leann Tilley
The malaria parasite, Plasmodium falciparum, displays the P. falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of infected red blood cells (RBCs). We here examine the physical organization of PfEMP1 trafficking intermediates in infected RBCs and determine interacting partners using an epitope-tagged minimal construct (PfEMP1B). We show that parasitophorous vacuole (PV)-located PfEMP1B interacts with components of the PTEX (Plasmodium Translocon of EXported proteins) as well as a novel protein complex, EPIC (Exported Protein-Interacting Complex)...
July 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28688112/consumption-of-fruits-vegetables-and-fruit-juices-and-differentiated-thyroid-carcinoma-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-study
#16
Raul Zamora-Ros, Virginie Béraud, Silvia Franceschi, Valerie Cayssials, Konstantinos K Tsilidis, Marie-Christine Boutron-Ruault, Elisabete Weiderpass, Kim Overvad, Anne Tjønneland, Anne Kirstine Eriksen, Fabrice Bonnet, Aurélie Affret, Verena Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Elisavet Valanou, Anna Karakatsani, Giovanna Masala, Sara Grioni, Maria Santucci de Magistris, Rosario Tumino, Fulvio Ricceri, Guri Skeie, Christine L Parr, Susana Merino, Elena Salamanca-Fernández, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Martin Almquist, Isabel Drake, Joakim Hennings, Maria Sandström, H Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Thee Khaw, Nicholas J Wareham, Julie A Schmidt, Aurora Perez-Cornago, Dagfinn Aune, Elio Riboli, Nadia Slimani, Augustin Scalbert, Isabelle Romieu, Antonio Agudo, Sabina Rinaldi
Fruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000...
July 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28678957/development-of-epic-pcr-markers-for-lutjanus-purpureus-lutjanidae-perciformes-and-their-potential-applicability-in-population-analyses
#17
Raimundo DA Silva, Danillo Silva, Ivana Veneza, Iracilda Sampaio, Horacio Schneider, Grazielle Gomes
In the present study, a novel set of eight EPIC primers were developed for Lutjanus purpureus and assayed in five other marine teleosts including three lutjanids, one scianid and one anablepid. Most of the genomic regions used in this study presented genetic diversity indexes equal or greater than the intragenic regions commonly used in population genetics studies. Moreover, six out of eight markers showed cross-amplification with other taxa. Thus, the primers described here may be used to elucidate questions at the intraspecific level for a large number of taxa...
June 29, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28676467/the-rules-of-engagement-perspectives-on-secure-messaging-from-experienced-ambulatory-patient-portal-users
#18
Cynthia J Sieck, Jennifer L Hefner, Jeanette Schnierle, Hannah Florian, Aradhna Agarwal, Kristen Rundell, Ann Scheck McAlearney
BACKGROUND: Patient portals have shown promise in engaging individuals in self-management of chronic conditions by allowing patients to input and track health information and exchange secure electronic messages with their providers. Past studies have identified patient barriers to portal use including usability issues, low health literacy, and concerns about loss of personal contact as well as provider concerns such as increased time spent responding to messages. However, to date, studies of both patient and provider perspectives on portal use have focused on the pre-implementation or initial implementation phases and do not consider how these issues may change as patients and providers gain greater experience with portals...
July 4, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28669505/bioprosthetic-valve-fracture-to-facilitate-transcatheter-valve-in-valve-implantation
#19
Keith B Allen, Adnan K Chhatriwalla, David J Cohen, John T Saxon, Sanjeev Aggarwal, Anthony Hart, Suzanne Baron, J Russell Davis, Alex F Pak, Danny Dvir, A Michael Borkon
BACKGROUND: Valve-in-valve transcatheter aortic valve replacement is less effective in small surgical bioprostheses. We evaluated the feasibility of bioprosthetic valve fracture with a high-pressure balloon to facilitate valve-in-valve transcatheter aortic valve replacement. METHODS: In vitro bench testing on aortic tissue valves was performed on 19-mm and 21-mm Mitroflow (Sorin, Milan, Italy), Magna and Magna Ease (Edwards Lifesciences, Irvine, CA), Trifecta and Biocor Epic (St...
June 29, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28663568/rare-variant-analysis-of-human-and-rodent-obesity-genes-in-individuals-with-severe-childhood-obesity
#20
Audrey E Hendricks, Elena G Bochukova, Gaëlle Marenne, Julia M Keogh, Neli Atanassova, Rebecca Bounds, Eleanor Wheeler, Vanisha Mistry, Elana Henning, Antje Körner, Dawn Muddyman, Shane McCarthy, Anke Hinney, Johannes Hebebrand, Robert A Scott, Claudia Langenberg, Nick J Wareham, Praveen Surendran, Joanna M Howson, Adam S Butterworth, John Danesh, Børge G Nordestgaard, Sune F Nielsen, Shoaib Afzal, Sofia Papadia, Sofie Ashford, Sumedha Garg, Glenn L Millhauser, Rafael I Palomino, Alexandra Kwasniewska, Ioanna Tachmazidou, Stephen O'Rahilly, Eleftheria Zeggini, Inês Barroso, I Sadaf Farooqi
Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants contributing to obesity in 2% of cases including multiple novel variants in GNAS, which were sometimes found with accelerated growth rather than short stature as described previously. Nominally significant associations were found for rare functional variants in BBS1, BBS9, GNAS, MKKS, CLOCK and ANGPTL6...
June 29, 2017: Scientific Reports
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