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https://www.readbyqxmd.com/read/28210527/major-oncologic-surgery-at-a-community-hospital
#1
Hollyann Loui, Pouya Benyamini, Gregorio Maldini
There is a national trend to refer patients requiring complex oncologic surgery to tertiary high-volume cancer centers. However, this presents major access challenges to Hawai'i patients seeking care. The purpose of this study is to demonstrate that complex oncologic surgery can be safely performed at community hospitals like those in Hawai'i. From July 2007 to December 2014, 136 patients underwent complex oncologic procedures at a community hospital in Hawai'i by a single general surgeon. Cases included esophagogastric, hepatobiliary, pancreatic, rectal, and retroperitoneal resections...
February 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28209443/continued-benefit-to-rectal-separation-for-prostate-radiation-therapy-final-results-of%C3%A2-a%C3%A2-phase-iii-trial
#2
Daniel A Hamstra, Neil Mariados, John Sylvester, Dhiren Shah, Lawrence Karsh, Richard Hudes, David Beyer, Steven Kurtzman, Jeffrey Bogart, R Alex Hsi, Michael Kos, Rodney Ellis, Mark Logsdon, Shawn Zimberg, Kevin Forsythe, Hong Zhang, Edward Soffen, Patrick Francke, Constantine Mantz, Peter Rossi, Theodore DeWeese, Stephanie Daignault-Newton, Benjamin W Fischer-Valuck, Anupama Chundury, Hiram Gay, Walter Bosch, Jeff Michalski
PURPOSE: SpaceOAR, a Food and Drug Administration-approved hydrogel intended to create a rectal-prostate space, was evaluated in a single-blind phase III trial of image guided intensity modulated radiation therapy. A total of 222 men were randomized 2:1 to the spacer or control group and received 79.2 Gy in 1.8-Gy fractions to the prostate with or without the seminal vesicles. The present study reports the final results with a median follow-up period of 3 years. METHODS AND MATERIALS: Cumulative (Common Terminology Criteria for Adverse Events, version 4...
December 23, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28205223/abdominal-adiposity-is-not-a-mediator-of-the-protective-effect-of-mediterranean-diet-on-colorectal-cancer
#3
Francesca Fasanelli, Daniela Zugna, Maria Teresa Giraudo, Vittorio Krogh, Sara Grioni, Salvatore Panico, Amalia Mattiello, Giovanna Masala, Saverio Caini, Rosario Tumino, Graziella Frasca, Veronica Sciannameo, Fulvio Ricceri, Carlotta Sacerdote
Adherence to the Mediterranean diet (MD) has a preventive effect on colorectal cancer (CRC). Several biological mechanisms have been hypothesized to explain this effect, but the involvement of clinical mediators has not been experimentally proven. We examined the role of abdominal adiposity (i.e. waist-to-hip ratio, WHR) as a potential mediator of the relationship between the MD and CRC in the Italian centres of the European Prospective Investigation into Cancer and Nutrition. We evaluated the effect of the Italian Mediterranean Index (IMI) on WHR and of WHR on CRC risk...
February 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28202064/prediagnostic-plasma-concentrations-of-organochlorines-and-risk-of-b-cell-non-hodgkin-lymphoma-in-envirogenomarkers-a-nested-case-control-study
#4
Rachel S Kelly, Hannu Kiviranta, Ingvar A Bergdahl, Domenico Palli, Ann-Sofie Johansson, Maria Botsivali, Paolo Vineis, Roel Vermeulen, Soterios A Kyrtopoulos, Marc Chadeau-Hyam
BACKGROUND: Evidence suggests a largely environmental component to non-Hodgkin's lymphoma (NHL). Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), DDE and HCB have been repeatedly implicated, but the literature is inconsistent and a causal relationship remains to be determined. METHODS: The EnviroGenoMarkers study is nested within two prospective cohorts EPIC-Italy and the Northern Sweden Health and Disease Study. Six PCB congeners, DDE and HCB were measured in blood plasma samples provided at recruitment using gas-chromatography mass spectrometry...
February 16, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28198990/corticosteroids-and-hip-fracture-risk-in-elderly-respiratory-patients-epic-greece-cohort
#5
Anna Karakatsani, Michail Katsoulis, Eleni Klinaki, Antonia Trichopoulou
INTRODUCTION: In an ageing population the prevalence of osteoporosis and chronic respiratory diseases is expected to increase in the near future. Interestingly, several forms of corticosteroids, drugs implicated in osteoporosis pathogenesis, are prescribed to respiratory patients without taking into consideration their age and risk for osteoporotic fractures. The aim of this study was to investigate the risk for hip fracture of the elder individuals who are taking corticosteroids for respiratory disease, including inhalers...
2017: Adv Respir Med
https://www.readbyqxmd.com/read/28194729/design-and-implementation-of-decision-support-for-tobacco-dependence-treatment-in-an-inpatient-electronic-medical-record-a-randomized-trial
#6
Steven L Bernstein, June Rosner, Michelle DeWitt, Jeanette Tetrault, Allen L Hsiao, James Dziura, Scott Sussman, Patrick O'Connor, Benjamin Toll
: Tobacco dependence treatment for hospitalized smokers results in long-term cessation if treatment continues at least 30 days post-discharge. Health information technology may facilitate ongoing tobacco dependence treatment after hospital discharge. To describe the use and impact of a new decision support tool and order set for inpatient physicians, addressing tobacco dependence treatment for hospitalized smokers, embedded in an electronic health record (EHR). In a cluster-randomized trial, 254 physicians were randomized (1:1) to either receive or not receive the decision support tool and order set, which were embedded in the Epic (Madison, WI) EHR used at 2 hospitals in a single city...
February 13, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28192535/correction-evidence-based-neonatal-unit-practices-and-determinants-of-postnatal-corticosteroid-use-in-preterm-births-below-30-weeks-ga-in-europe-a-population-based-cohort-study
#7
Alexandra Nuytten, Hélène Behal, Alain Duhamel, Pierre-Henri Jarreau, Jan Mazela, David Milligan, Ludwig Gortner, Aurélie Piedvache, Jennifer Zeitlin, Patrick Truffert
[This corrects the article DOI: 10.1371/journal.pone.0170234.].
2017: PloS One
https://www.readbyqxmd.com/read/28190638/long-term-toxicity-and-health-related-quality-of-life-after-single-fraction-high-dose-rate-brachytherapy-boost-and-hypofractionated-external-beam-radiotherapy-for-intermediate-risk-prostate-cancer
#8
N Shahid, A Loblaw, H T Chung, P Cheung, E Szumacher, C Danjoux, R Sankreacha, L Zhang, A Deabreu, A Mamedov, G Morton
AIMS: To report health-related quality of life (HRQOL) and toxicity in prostate cancer patients treated with single-fraction high dose rate (HDR) brachytherapy boost and external beam radiotherapy (EBRT). MATERIALS AND METHODS: Patients with intermediate-risk prostate cancer were accrued to a phase II clinical trial of 15 Gy HDR boost and EBRT to a dose of 37.5 Gy in 15 fractions. HRQOL (Expanded Prostate Cancer Index Composite [EPIC]), urinary symptoms (International Prostate Symptom Score [IPSS]), erectile function (International Index of Erectile Function [IIEF]) and toxicity (Common Terminology Criteria for Adverse Events [CTCAE], version 3...
February 9, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28183827/measured-adiposity-in-relation-to-head-and-neck-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition
#9
Heather A Ward, Petra A Wark, David C Muller, Annika Steffen, Mattias Johansson, Teresa Norat, Marc J Gunter, Kim Overvad, Christina C Dahm, Jytte Halkjær, Anne Tjønneland, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Sylvie Mesrine, Paul Brennan, Heinz Freisling, Kuanrong Li, Rudolf Kaaks, Antonia Trichopoulou, Pagona Lagiou, Salvatore Panico, Sara Grioni, Rosario Tumino, Paolo Vineis, Domenico Palli, Petra H M Peeters, H Bas Bueno-de-Mesquita, Elisabete Weiderpass, Antonio Agudo, Jose Ramon Quiros, Nerea Larrañaga, Eva Ardanaz, José María Huerta, María-José Sánchez, Goran Laurell, Ingegerd Johansson, Ulla Westin, Peter Wallstrom, Kathryn E Bradbury, Nicholas J Wareham, Kay-Tee Khaw, Clare Pearson, Heiner Boeing, Elio Riboli
BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error. METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of HNC. HNC risk was examined in relation to body mass index (BMI) [lean: < 22...
February 9, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28179041/standardization-of-mri-data-and-disability-quantification-in-the-post-epic-era
#10
Jagannadha Avasarala
No abstract text is available yet for this article.
February 9, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28173834/osteoprotegerin-and-breast-cancer-risk-by-hormone-receptor-subtype-a-nested-case-control-study-in-the-epic-cohort
#11
Renée T Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H Bas Bueno-de-Mesquita, Petra H M Peeters, Carla H Van Gils, Elisabete Weiderpass, Eiliv Lund, J Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A Merritt, Elio Riboli, Rudolf Kaaks
BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. METHODS: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
February 8, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28170373/mediterranean-diet-and-risk-of-pancreatic-cancer-in-the-european-prospective-investigation-into-cancer-and-nutrition-cohort
#12
Esther Molina-Montes, María-José Sánchez, Genevieve Buckland, H B As Bueno-de-Mesquita, Elisabete Weiderpass, Pilar Amiano, Petra A Wark, Tilman Kühn, Verena Katzke, José María Huerta, Eva Ardanaz, José Ramón Quirós, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Petra H Peeters, Weimin Ye, Malin Sund, Heiner Boeing, Khalid Iqbal, Bodil Ohlsson, Emily Sonestedt, Anne Tjønneland, Kristina En Petersen, Ruth C Travis, Guri Skeie, Claudia Agnoli, Salvatore Panico, Domenico Palli, Rosario Tumino, Carlotta Sacerdote, Heinz Freisling, Inge Huybrechts, Kim Overvad, Antonia Trichopoulou, Christina Bamia, Effie Vasilopoulou, Nick Wareham, Kay-Tee Khaw, Amanda J Cross, Heather A Ward, Elio Riboli, Eric J Duell
BACKGROUND: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified...
February 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28168601/long-term-follow-up-after-active-surveillance-or-curative-treatment-quality-of-life-outcomes-of-men-with-low-risk-prostate-cancer
#13
Lionne D F Venderbos, Shafak Aluwini, Monique J Roobol, Leonard P Bokhorst, Eric H G M Oomens, Chris H Bangma, Ida J Korfage
PURPOSE: To compare long-term (4-10 years) quality of life (QoL) of men with low-risk prostate cancer (PCa) treated by different modalities and a reference group without PCa. METHODS: In this cross-sectional study, four groups were sent a one-time QoL-questionnaire; PCa patients (1) following the structured Prostate cancer Research International Active Surveillance protocol, (2) who underwent radical prostatectomy (RP) in the context of the European Randomized study of Screening for Prostate Cancer-section Rotterdam, (3) who underwent radiotherapy (RT) at an academic hospital in The Netherlands, and (4) an age-matched reference group of men without PCa...
February 6, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28159493/alcohol-consumption-and-the-risk-of-renal-cancers-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-wozniak-mb-brennan-p-brenner-dr-overvad-k-olsen-a-tj%C3%A3-nneland-a-boutron-ruault-mc-clavel-chapelon-f-fagherazzi-g-katzke-v-k%C3%A3-hn-t-boeing
#14
Raman Jay, P Brennan, Brenner, K Overvad, A Olsen, A Tjønneland, M C Boutron-Ruault, F Clavel-Chapelon, Fagherazzi, V Katzke, T Kühn, H Boeing, M M Bergmann, A Steffen, A Naska, A Trichopoulou, D Trichopoulos, C Saieva, S Grioni, S Panico, R Tumino, P Vineis, H B Bueno-de-Mesquita, P H Peeters, A Hjartåker, E Weiderpass, L Arriola, E Molina-Montes, E J Duell, C Santiuste, R Alonso de la Torre, A Barricarte Gurrea, T Stocks, M Johansson, B Ljungberg, N Wareham, K T Khaw, R C Travis, A J Cross, N Murphy, E Riboli, G Scelo
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires...
January 31, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28156632/end-of-life-care-for-glioblastoma-multiforme-gbm-patients-at-a-large-academic-center
#15
Xiao Wang, Jiangxia Wang, Anne Evans, W Anthony Riley, Thomas J Smith
: 56 Background: GBM is a uniformly fatal disease with average survival of < 3 years and universal cognitive problems, making advance care planning paramount. End of life (EOL) patterns of GBM care in the US have not been studied. We examined care in a cohort of GBM and brain tumor (BT) patients as part of a program to provide individual provider feedback about EOL care. METHODS: We reviewed the care of all GBM patients over 3 years with a random sample of 100, and a 5-yr subset of 45 who received their care at Gilchrist Hospice (GH), our largest provider...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28155612/the-influence-of-dietary-components-on-early-signs-of-atherosclerosis-in-apparently-healthy-young-adult-males-an-observational-study-of-615-subjects
#16
Girolamo Catapano Minotti, Francesca Cortese, Andrea Corsonello, Giovanni Guadalupi, Antonio Paolo D Arcangelo, Saverio Daniele Palumbo, Rita Naio, Ottovio De Clemente, Andrea Aurelio, Simona Carone, Tiziana Gelsumino, Vincenzo Gemignani, Elisabetta Bianchini, Mariangela Vigotti, Francesco Faita, Luciano Greco, Roberto Primerano, Raffaele Antonelli Incalzi, Marco Matteo Ciccone
BACKGROUND: the literature shows that a healthy diet, rich in fruits and vegetables, has positive effects on overall cardiovascular risk, protecting against atherosclerosis. DESIGN: a cross sectional study in a population of apparently healthy young-adult men with the aim of investigating dietary determinants of early atherosclerosis, assessed by measuring carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) of the brachial artery. METHODS: 615 males (mean age ± SD: 40...
February 1, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28152928/integration-of-a-clinical-pathways-software-into-an-ehr-in-a-large-multisite-hospital-affiliated-community-oncology-setting
#17
Thomas James Saphner, Jacob C Frick, Carol Huibregtse, Gail S Stiemke
: 129 Background: Via Oncology (Via) is a decision support tool that integrates patient information, their disease, and goals of care to develop a treatment algorithm. Via prioritizes treatments by efficacy first, toxicity second, and cost third. The recommended regimen is offered to the doctor and patient who may accept it or choose an off pathway treatment. The pathways are updated quarterly and are expected to speed the integration of new treatments into practice, standardize therapy, improve quality, and decrease cost...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152915/a-pragmatic-approach-for-measuring-and-monitoring-hospitalizations-in-patients-receiving-chemotherapy-for-pancreatic-cancer
#18
Carole Kathleen Dalby, Saira Chaudary, Joseph O Jacobson
: 278 Background: Hospitalizations in patients receiving chemotherapy are common and costly. In order to test interventions to reduce hospitalizations in chemotherapy patients, efficient approaches are needed for monitoring the incidence of hospitalization. METHODS: We evaluated the monthly frequency of hospitalization in patients receiving active chemotherapy for pancreas cancer. Two definitions were used to identify patients under "active" chemotherapy treatment in a given month; both definitions required that patients were alive on the first day of the evaluation month...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152912/an-electronic-intervention-to-improve-structured-cancer-stage-data-capture
#19
Kim Framski, Patricia Lazette, Teresita Vega, Rogerio Lilenbaum
: 151 Background: Cancer Staging is critical for prognosticating, treatment planning, outcomes analysis, registry reporting and clinical trial eligibility determination. Oncology EHRs have structured staging modules but use by physicians is inconsistent. Typically, stage is entered as unstructured free text in clinical notes and cannot be used for reporting. Instead, institutions depend the tumor registry (TR) which typically lag 6 months behind. Our Cancer Committee determined that real-time capture of structured cancer staging was an imperative...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152900/hardwiring-advance-directives-into-an-electronic-medical-record
#20
Tyler Buckley, Andrew Badke, Amy Horyna, Julie Howell, Lisa Gren, Anna Catherine Beck
: 146 Background: Patient preference at the end of life has been extensively researched and documented. Advance Directives (AD) have been shown to make a difference for patients in the areas of quality, cost, and patient satisfaction. Organizations struggle with meeting federal laws and accreditation expectations due to our complex systems. Literature supports "hardwiring" AD documentation into the EMR and providing "one click" accessibility to AD's. Changing EMR vendors provides a unique opportunity to optimize access to AD's, both through patient education /endorsement, review of providers' role, and engagement of IT...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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