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https://www.readbyqxmd.com/read/28818343/high-dietary-phosphorus-intake-is-associated-with-an-increased-risk-of-type-2-diabetes-in-the-large-prospective-e3n-cohort-study
#1
Francesca Romana Mancini, Aurélie Affret, Courtney Dow, Beverley Balkau, Françoise Clavel-Chapelon, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi
Phosphorus is an essential nutrient; the adult recommended daily intake ranges from 550 to 700 mg/day, with a tolerated upper limit of 4000 mg/day. Phosphorus intake has increased in the general population in recent years, and simultaneously an alarming rise of type 2 diabetes incidences has been observed. No study has investigated the relationship between phosphorus intake and the risk of type 2 diabetes. To evaluate the association between phosphorus intake and incidence of type 2 diabetes. Among 71,270 women from the French E3N-EPIC cohort, 1845 cases of incident type 2 diabetes were validated during follow-up (1993-2011)...
August 5, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28809127/the-correlation-of-methylation-levels-measured-using-illumina-450k-and-epic-beadchips-in-blood-samples
#2
Mark W Logue, Alicia K Smith, Erika J Wolf, Hannah Maniates, Annjanette Stone, Steven A Schichman, Regina E McGlinchey, William Milberg, Mark W Miller
AIM: We examined concordance of methylation levels across the Illumina Infinium HumanMethylation450 BeadChip and the Infinium MethylationEPIC BeadChip. METHODS: We computed the correlation for 145 whole blood DNA samples at each of the 422,524 CpG sites measured by both chips. RESULTS: The correlation at some sites was high (up to r = 0.95), but many sites had low correlation (55% had r < 0.20). The low correspondence between 450K and EPIC measured methylation values at many loci was largely due to the low variability in methylation values for the majority of the CpG sites in blood...
August 15, 2017: Epigenomics
https://www.readbyqxmd.com/read/28808480/salvage-chemotherapy-for-adults-with-relapsed-or-refractory-lymphoma-in-malawi
#3
Bongani Kaimila, Toon van der Gronde, Christopher Stanley, Edwards Kasonkanji, Maria Chikasema, Blessings Tewete, Paula Fox, Satish Gopal
BACKGROUND: Lymphoma is highly associated with HIV in sub-Saharan Africa (SSA), which contributes to worse outcomes relative to resource-rich settings, and frequent failure of first-line chemotherapy. However, there are no second-line treatment descriptions for adults with relapsed or refractory lymphoma (RRL) in SSA. METHODS: We describe HIV+ and HIV- patients with RRL receiving salvage chemotherapy in Malawi. Patients were prospectively treated at a national teaching hospital in Lilongwe, with the modified EPIC regimen (etoposide, prednisolone, ifosfamide, cisplatin) between June 2013 and May 2016, after failing prior first-line chemotherapy...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28805510/review-of-market-vs-medicine-america-s-epic-fight-for-better-affordable-healthcare-by-d-w-johnson
#4
David Singer
No abstract text is available yet for this article.
August 14, 2017: Population Health Management
https://www.readbyqxmd.com/read/28800250/ventilator-induced-lung-injury-follow-the-right-direction-another-piece-of-the-puzzle-in-the-vili-epic
#5
Antoine Vieillard-Baron, Didier Dreyfuss
No abstract text is available yet for this article.
August 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28794012/surgeon-major-thomas-heazle-parke-1857-1893-irish-doctor-soldier-and-explorer
#6
EDITORIAL
Andrew Parke
Surgeon Major Thomas Heazle Parke (1857-1893) was a doctor from Drumsna, County Roscommon, who after completing his education at the Royal College of Surgeons in Ireland joined the British army as a medical officer. After several years of serving in Ireland and Egypt, he volunteered to be medical officer of the Emin Pasha Relief Expedition of 1887-1889. This was to become Henry Morton Stanley's largest, longest and most controversial African expedition. The epic journey saw Stanley, his eight European officers and 800 African porters take almost 3 years to cross the African continent from West to East via the Congo River, Southern Sudan and Uganda...
August 8, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28775061/association-of-high-density-lipoprotein-cholesterol-versus-apolipoprotein-a-i-with-risk-of-coronary-heart-disease-the-european-prospective-investigation-into-cancer-norfolk-prospective-population-study-the-atherosclerosis-risk-in-communities-study-and-the-women
#7
Julian C van Capelleveen, Andrea E Bochem, S Matthijs Boekholdt, Samia Mora, Ron C Hoogeveen, Christie M Ballantyne, Paul M Ridker, Wensheng Sun, Philip J Barter, Alan R Tall, Aeilko H Zwinderman, John J P Kastelein, Nick J Wareham, Kay-Tee Khaw, G Kees Hovingh
BACKGROUND: The contribution of apolipoprotein A-I (apoA-I) to coronary heart disease (CHD) risk stratification over and above high-density lipoprotein cholesterol (HDL-C) is unclear. We studied the associations between plasma levels of HDL-C and apoA-I, either alone or combined, with risk of CHD events and cardiovascular risk factors among apparently healthy men and women. METHODS AND RESULTS: HDL-C and apoA-I levels were measured among 17 661 participants of the EPIC (European Prospective Investigation into Cancer)-Norfolk prospective population study...
August 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28761257/from-hair-in-india-to-hair-india
#8
COMMENT
Ralph M Trüeb
In all cultures, human hair and hairdo have been a powerful metaphor. Tracing back the importance and significance of human hair to the dawn of civilization on the Indian subcontinent, we find that all the Vedic gods are depicted as having uncut hair in mythological stories as well as in legendary pictures. The same is true of the Hindu avatars, and the epic heroes of the Ramayana, and the Mahabharata. Finally, there are a number of hair peculiarities in India pertinent to the creed and religious practices of the Hindu, the Jain, and the Sikh...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28758405/blood-metabolic-signatures-of-body-mass-index-a-targeted-metabolomics-study-in-the-epic-cohort
#9
Marion Carayol, Michael F Leitzmann, Pietro Ferrari, Raul Zamora-Ros, David Achaintre, Magdalena Stepien, Julie A Schmidt, Ruth C Travis, Kim Overvad, Anne Tjønneland, Louise Hansen, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Ursula Bachlechner, Antonia Trichopoulou, Christina Bamia, Domenico Palli, Claudia Agnoli, Rosario Tumino, Paolo Vineis, Salvatore Panico, J Ramón Quirós, Emilio Sanchez-Cantalejo, José María Huerta, Eva Ardanaz, Larraitz Arriola, Antonio Agudo, Jan Nilsson, Olle Melander, Bas Bueno-de-Mesquita, Petra H Peeters, Nick Wareham, Kay-Tee Khaw, Mazda Jenab, Timothy J Key, Augustin Scalbert, Sabina Rinaldi
OBJECTIVE: Metabolomic is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. METHODS: Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary)...
July 31, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28758177/the-5-year-outcomes-of-moderately-hypofractionated-radiotherapy-66%C3%A2-gy-in-22-fractions-3-fractions-per-week-for-localized-prostate-cancer-a-retrospective-study
#10
Yaichiro Hashimoto, Atsushi Motegi, Tetsuo Akimoto, Norio Mitsuhashi, Junpei Iizuka, Kazunari Tanabe, Yuka Ishii, Sawa Kono, Sachiko Izumi, Kumiko Karasawa
BACKGROUND: Hypofractionated radiotherapy using fewer and larger fractional doses may be more beneficial than conventional external-beam radiotherapy for localized prostate cancer. We evaluated the 5-year outcomes of moderately hypofractionated radiotherapy for localized prostate cancer. METHODS: We retrospectively evaluated 195 patients with localized prostate cancer (T1-3N0M0) who underwent intensity-modulated radiotherapy (IMRT) (66 Gy delivered in fractions of 3 Gy every other weekday) between May 2005 and December 2011...
July 31, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28757581/identification-of-urinary-polyphenol-metabolite-patterns-associated-with-polyphenol-rich-food-intake-in-adults-from-four-european-countries
#11
Hwayoung Noh, Heinz Freisling, Nada Assi, Raul Zamora-Ros, David Achaintre, Aurélie Affret, Francesca Mancini, Marie-Christine Boutron-Ruault, Anna Flögel, Heiner Boeing, Tilman Kühn, Ruth Schübel, Antonia Trichopoulou, Androniki Naska, Maria Kritikou, Domenico Palli, Valeria Pala, Rosario Tumino, Fulvio Ricceri, Maria Santucci de Magistris, Amanda Cross, Nadia Slimani, Augustin Scalbert, Pietro Ferrari
We identified urinary polyphenol metabolite patterns by a novel algorithm that combines dimension reduction and variable selection methods to explain polyphenol-rich food intake, and compared their respective performance with that of single biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 475 adults from four European countries (Germany, France, Italy, and Greece). Dietary intakes were assessed with 24-h dietary recalls (24-HDR) and dietary questionnaires (DQ)...
July 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28755806/physical-activity-and-blood-pressure-in-10-000-mediterranean-adults-the-epic-florence-cohort
#12
G Masala, B Bendinelli, D Occhini, R M Bruno, S Caini, C Saieva, A Ungar, L Ghiadoni, D Palli
BACKGROUND AND AIMS: The relevant role of physical activity (PA) in cardiovascular risk prevention is widely agreed. We aimed to evaluate, in a large Mediterranean population, the influence of PA on systolic (SBP) and diastolic blood pressure (DBP), taking into account individual characteristics and lifestyle habits. METHODS AND RESULTS: In the Florence section of the European Prospective Investigation into Cancer and Nutrition 10,163 individuals, 35-64 years, without a previous diagnosis of hypertension were recruited...
June 15, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28740168/compounding-impacts-of-human-induced-water-stress-and-climate-change-on-water-availability
#13
Ali Mehran, Amir AghaKouchak, Navid Nakhjiri, Michael J Stewardson, Murray C Peel, Thomas J Phillips, Yoshihide Wada, Jakin K Ravalico
The terrestrial phase of the water cycle can be seriously impacted by water management and human water use behavior (e.g., reservoir operation, and irrigation withdrawals). Here we outline a method for assessing water availability in a changing climate, while explicitly considering anthropogenic water demand scenarios and water supply infrastructure designed to cope with climatic extremes. The framework brings a top-down and bottom-up approach to provide localized water assessment based on local water supply infrastructure and projected water demands...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739839/dog-ownership-supports-the-maintenance-of-physical-activity-during-poor-weather-in-older-english-adults-cross-sectional-results-from-the-epic-norfolk-cohort
#14
Yu-Tzu Wu, Robert Luben, Andy Jones
BACKGROUND: Dog ownership has been suggested to encourage physical activity in older adults and may enhance resilience to poor environmental conditions. This study investigates the role of dog ownership and walking as a means of supporting the maintenance of physical activity in older adults during periods of inclement weather. METHODS: The analysis used data from the European Prospective Investigation into Cancer and Nutrition Norfolk cohort. Daily physical activity (counts per minute) and minutes of sedentary behaviour were measured using accelerometers over 7 days...
July 24, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28739187/fluidity-of-the-dietary-fatty-acid-profile-and-risk-of-coronary-heart-disease-and-ischemic-stroke-results-from-the-epic-netherlands-cohort-study
#15
I Sluijs, J Praagman, J M A Boer, W M M Verschuren, Y T van der Schouw
BACKGROUND AND AIMS: The fluidity of dietary fatty acids consumed has been suggested to inversely affect coronary heart disease (CHD) risk. Lipophilic index (LI) represents overall fluidity of the dietary fatty acid profile. Lipophilic load (LL) represents a combination of overall fluidity and absolute intake of dietary fatty acids. We investigated the relations of dietary LI and LL with risk of CHD and ischemic stroke (iStroke). METHODS AND RESULTS: We used data from the prospective EPIC-NL study, including 36,520 participants aged 20-70 years...
June 21, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28733927/nut-intake-and-5-year-changes-in-body-weight-and-obesity-risk-in-adults-results-from-the-epic-panacea-study
#16
Heinz Freisling, Hwayoung Noh, Nadia Slimani, Véronique Chajès, Anne M May, Petra H Peeters, Elisabete Weiderpass, Amanda J Cross, Guri Skeie, Mazda Jenab, Francesca R Mancini, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Verena A Katzke, Tilman Kühn, Annika Steffen, Heiner Boeing, Anne Tjønneland, Cecilie Kyrø, Camilla P Hansen, Kim Overvad, Eric J Duell, Daniel Redondo-Sánchez, Pilar Amiano, Carmen Navarro, Aurelio Barricarte, Aurora Perez-Cornago, Konstantinos K Tsilidis, Dagfinn Aune, Heather Ward, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Giovanna Masala, Claudia Agnoli, Franco Berrino, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, H Bas Bueno-de-Mesquita, Ulrika Ericson, Emily Sonestedt, Anna Winkvist, Tonje Braaten, Isabelle Romieu, Joan Sabaté
PURPOSE: There is inconsistent evidence regarding the relationship between higher intake of nuts, being an energy-dense food, and weight gain. We investigated the relationship between nut intake and changes in weight over 5 years. METHODS: This study includes 373,293 men and women, 25-70 years old, recruited between 1992 and 2000 from 10 European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Habitual intake of nuts including peanuts, together defined as nut intake, was estimated from country-specific validated dietary questionnaires...
July 21, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28729637/genetic-variants-including-markers-from-the-exome-chip-and-metabolite-traits-of-type-2-diabetes
#17
Susanne Jäger, Simone Wahl, Janine Kröger, Sapna Sharma, Per Hoffmann, Anna Floegel, Tobias Pischon, Cornelia Prehn, Jerzy Adamski, Martina Müller-Nurasyid, Melanie Waldenberger, Konstantin Strauch, Annette Peters, Christian Gieger, Karsten Suhre, Harald Grallert, Heiner Boeing, Matthias B Schulze, Karina Meidtner
Diabetes-associated metabolites may aid the identification of new risk variants for type 2 diabetes. Using targeted metabolomics within a subsample of the German EPIC-Potsdam study (n = 2500), we tested previously published SNPs for their association with diabetes-associated metabolites and conducted an additional exploratory analysis using data from the exome chip including replication within 2,692 individuals from the German KORA F4 study. We identified a total of 16 loci associated with diabetes-related metabolite traits, including one novel association between rs499974 (MOGAT2) and a diacyl-phosphatidylcholine ratio (PC aa C40:5/PC aa C38:5)...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28728989/caution-with-use-of-the-expanded-prostate-cancer-index-composite-50-urinary-bother-scale-how-voiding-dysfunction-modifies-its-performance
#18
Lin Yang, Adam S Kibel, Graham A Colditz, Ratna Pakpahan, Kellie R Imm, Sonya Izadi, Robert L Grubb, Kathleen Y Wolin, Siobhan Sutcliffe
PURPOSE: We evaluated the agreement between patient-reported urinary function and bother, and sexual function and bother in radical prostatectomy (RP) patients to help inform possible non-functional, modifiable mechanisms for patient bother. METHODS: Patients were recruited from 2011-2014 at Washington University and Brigham & Women's Hospital. Urinary and sexual outcomes were assessed by the Expanded Prostate Cancer Index Composite-50 (EPIC-50) before, five weeks, and 12 months after RP...
July 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28721888/long-term-quality-of-life-in-prostate-cancer-patients-treated-with-cesium-131
#19
Scott M Glaser, Katherine S Chen, Ronald M Benoit, Ryan P Smith, Sushil Beriwal
PURPOSE: To evaluate long-term patient-reported quality of life (QOL) scores in men with prostate cancer treated at our institution with (131)Cs prostate brachytherapy. METHODS AND MATERIALS: Patients treated more than 4 years ago with (131)Cs (n=290) were asked to fill out an Expanded Prostate Cancer Index Composite (EPIC) QOL questionnaire and American Urological Association Symptom Score (AUASS) survey, before treatment and at each follow-up appointment. We compared patients' EPIC and AUA scores at baseline with scores at a last follow-up of at least 4 years after treatment using the Wilcoxon signed-rank test...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28716665/applying-label-free-dynamic-mass-redistribution-assay-for-studying-endogenous-fpr1-receptor-signalling-in-human-neutrophils
#20
Hanna B Christensen, David E Gloriam, Daniel Sejer Pedersen, Jack B Cowland, Niels Borregaard, Hans Bräuner-Osborne
INTRODUCTION: The label-free dynamic mass redistribution-based assay (DMR) is a powerful method for studying signalling pathways of G protein-coupled receptors (GPCRs). Herein we present the label-free DMR assay as a robust readout for pharmacological characterization of formyl peptide receptors (FPRs) in human neutrophils. METHODS: Neutrophils were isolated from fresh human blood and their responses to FPR1 and FPR2 agonists, i.e. compound 43, fMLF and WKYMVm were measured in a label-free DMR assay using Epic Benchtop System from Corning®...
July 15, 2017: Journal of Pharmacological and Toxicological Methods
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