keyword
https://read.qxmd.com/read/34307726/forgiveness-of-dolutegravir-based-triple-therapy-compared-with-older-antiretroviral-regimens-a-prospective-multicenter-cohort-of-adherence-patterns-and-hiv-rna-replication
#1
JOURNAL ARTICLE
Jean-Jacques Parienti, Anna L Fournier, Laurent Cotte, Marie-Paule Schneider, Manuel Etienne, Guillemette Unal, Philippe Perré, Jean-Jacques Dutheil, Elodie Morilland-Lecoq, Fabien Chaillot, David R Bangsberg, Amandine Gagneux-Brunon, Thierry Prazuck, Matthias Cavassini, Renaud Verdon, Laurent Hocqueloux
BACKGROUND: For many people with HIV (PWH), taking antiretroviral therapy (ARV) every day is difficult. METHODS: Average adherence (Av-Adh) and log-transformed treatment interruption (TI) to ARV were prospectively measured over 6 months using electronic drug monitoring (EDM) in several cohorts of PWH. Multivariate linear regression models including baseline confounders explored the influence of EDM-defined adherence ( R 2 ) on 6-month log10 HIV-RNA. Multivariate logistic regression models were used to compare the risk of HIV-RNA detection (VR) within subgroups stratified by lower (≤95%) and higher (>95%) Av-Adh...
July 2021: Open Forum Infectious Diseases
https://read.qxmd.com/read/28760728/enabling-open-science-for-health-research-collaborative-informatics-environment-for-learning-on-health-outcomes-cielo
#2
JOURNAL ARTICLE
Philip Payne, Omkar Lele, Beth Johnson, Erin Holve
BACKGROUND: There is an emergent and intensive dialogue in the United States with regard to the accessibility, reproducibility, and rigor of health research. This discussion is also closely aligned with the need to identify sustainable ways to expand the national research enterprise and to generate actionable results that can be applied to improve the nation's health. The principles and practices of Open Science offer a promising path to address both goals by facilitating (1) increased transparency of data and methods, which promotes research reproducibility and rigor; and (2) cumulative efficiencies wherein research tools and the output of research are combined to accelerate the delivery of new knowledge in proximal domains, thereby resulting in greater productivity and a reduction in redundant research investments...
July 31, 2017: Journal of Medical Internet Research
https://read.qxmd.com/read/27683671/concordium-2015-strategic-uses-of-evidence-to-transform-delivery-systems
#3
JOURNAL ARTICLE
Erin Holve, Samantha Weiss
In September 2015 the EDM Forum hosted AcademyHealth's newest national conference, Concordium. The 11 papers featured in the eGEMs "Concordium 2015" special issue successfully reflect the major themes and issues discussed at the meeting. Many of the papers address informatics or methodological approaches to natural language processing (NLP) or text analysis, which is indicative of the importance of analyzing text data to gain insights into care coordination and patient-centered outcomes. Perspectives on the tools and infrastructure requirements that are needed to build learning health systems were also recurrent themes...
2016: EGEMS
https://read.qxmd.com/read/27429993/open-science-and-egems-our-role-in-supporting-a-culture-of-collaboration-in-learning-health-systems
#4
JOURNAL ARTICLE
Erin Holve
"Open science" includes a variety of approaches to facilitate greater access to data and the information produced by processes of scientific inquiry. Recently, the health sciences community has been grappling with the issue of potential pathways and models to achieve the goals of open science-namely, to create and rapidly share reproducible health research. eGEMs' continued dedication to and milestones regarding the publication of innovative, useful, and timely research to help contribute to the push towards open science is discussed, as well as the EDM Forum's new data sharing platform, CIELO...
2016: EGEMS
https://read.qxmd.com/read/26263424/data-mining-and-education
#5
REVIEW
Kenneth R Koedinger, Sidney D'Mello, Elizabeth A McLaughlin, Zachary A Pardos, Carolyn P Rosé
An emerging field of educational data mining (EDM) is building on and contributing to a wide variety of disciplines through analysis of data coming from various educational technologies. EDM researchers are addressing questions of cognition, metacognition, motivation, affect, language, social discourse, etc. using data from intelligent tutoring systems, massive open online courses, educational games and simulations, and discussion forums. The data include detailed action and timing logs of student interactions in user interfaces such as graded responses to questions or essays, steps in rich problem solving environments, games or simulations, discussion forum posts, or chat dialogs...
July 2015: Wiley Interdisciplinary Reviews. Cognitive Science
https://read.qxmd.com/read/24303241/a-comprehensive-framework-for-data-quality-assessment-in-cer
#6
JOURNAL ARTICLE
Erin Holve, Michael Kahn, Meredith Nahm, Patrick Ryan, Nicole Weiskopf
The panel addresses the urgent need to ensure that comparative effectiveness research (CER) findings derived from diverse and distributed data sources are based on credible, high-quality data; and that the methods used to assess and report data quality are consistent, comprehensive, and available to data consumers. The panel consists of representatives from four teams leveraging electronic clinical data for CER, patient centered outcomes research (PCOR), and quality improvement (QI) and seeks to change the current paradigm where data quality assessment (DQA) is performed "behind the scenes" using one-off project specific methods...
2013: AMIA Summits on Translational Science Proceedings
https://read.qxmd.com/read/23793048/lessons-from-the-electronic-data-methods-forum-collaboration-at-the-frontier-of-comparative-effectiveness-research-patient-centered-outcomes-research-and-quality-improvement
#7
Erin Holve, Ned Calonge
BACKGROUND: The Electronic Data Methods (EDM) Forum, with support from the Agency for Healthcare Research and Quality, exists to advance knowledge and practice on the use of electronic clinical data (ECD) for comparative effectiveness research, patient-centered outcomes research, and quality improvement (QI). The EDM Forum facilitates collaboration between the Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies, Scalable Distributed Research Network, and Enhanced registry projects funded by Agency for Healthcare Research and Quality...
August 2013: Medical Care
https://read.qxmd.com/read/22692262/the-electronic-data-methods-edm-forum-for-comparative-effectiveness-research-cer
#8
JOURNAL ARTICLE
Erin Holve, Courtney Segal, Marianne Hamilton Lopez, Alison Rein, Beth H Johnson
BACKGROUND: AcademyHealth convened the Electronic Data Methods (EDM) Forum to collect, synthesize, and share lessons from eleven projects that are building infrastructure and using electronic clinical data for comparative effectiveness research (CER) and patient-centered outcomes research (PCOR). This paper provides a brief review of participating projects and provides a framework of common challenges. METHODS: EDM Forum staff conducted a text review of relevant grant programs' funding opportunity announcements; projects' research plans; and available information on projects' websites...
July 2012: Medical Care
https://read.qxmd.com/read/22692252/opportunities-and-challenges-for-comparative-effectiveness-research-cer-with-electronic-clinical-data-a-perspective-from-the-edm-forum
#9
JOURNAL ARTICLE
Erin Holve, Courtney Segal, Marianne Hamilton Lopez
INTRODUCTION: The Electronic Data Methods (EDM) Forum brings together perspectives from the Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies (PROSPECT) studies, the Scalable Distributed Research Networks, and the Enhanced Registries projects. This paper discusses challenges faced by the research teams as part of their efforts to develop electronic clinical data (ECD) infrastructure to support comparative effectiveness research (CER). The findings reflect a set of opportunities for transdisciplinary learning, and will ideally enhance the transparency and generalizability of CER using ECD...
July 2012: Medical Care
https://read.qxmd.com/read/22692251/edm-forum-supplement-overview
#10
Ned Calonge
BACKGROUND: The Agency for Health Research and Quality funded the Electronic Data Methods Forum (EDM Forum) to share the experiences and learnings from 11 research teams funded through three different grant programs, each of which involve the use of electronic clinical data in Comparative Effectiveness Research and Patient-Centered Outcomes Research. OBJECTIVES: This overview is meant to describe the context in which the EDM forum was created and to introduce the set of papers in this supplement to Medical Care that describe the challenges and approaches to the use of electronic clinical data in the three key areas of analytic methods, clinical informatics and data governance...
July 2012: Medical Care
https://read.qxmd.com/read/22692250/electronic-data-methods-edm-forum-building-the-infrastructure-to-conduct-comparative-effectiveness-research-and-patient-centered-outcomes-research-using-electronic-clinical-data
#11
EDITORIAL
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