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Clinical research informatics

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https://www.readbyqxmd.com/read/27899636/the-monarch-initiative-an-integrative-data-and-analytic-platform-connecting-phenotypes-to-genotypes-across-species
#1
Christopher J Mungall, Julie A McMurry, Sebastian Köhler, James P Balhoff, Charles Borromeo, Matthew Brush, Seth Carbon, Tom Conlin, Nathan Dunn, Mark Engelstad, Erin Foster, J P Gourdine, Julius O B Jacobsen, Dan Keith, Bryan Laraway, Suzanna E Lewis, Jeremy NguyenXuan, Kent Shefchek, Nicole Vasilevsky, Zhou Yuan, Nicole Washington, Harry Hochheiser, Tudor Groza, Damian Smedley, Peter N Robinson, Melissa A Haendel
The correlation of phenotypic outcomes with genetic variation and environmental factors is a core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient phenotypes may not match known diseases, candidate variants may be in genes that have not been characterized, model organisms may not recapitulate human or veterinary diseases, filling evolutionary gaps is difficult, and many resources must be queried to find potentially significant genotype-phenotype associations. Non-human organisms have proven instrumental in revealing biological mechanisms...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27891528/preparing-nursing-home-data-from-multiple-sites-for-clinical-research-a-case-study-using-observational-health-data-sciences-and-informatics
#2
Richard D Boyce, Steven M Handler, Jordan F Karp, Subashan Perera, Charles F Reynolds
INTRODUCTION: A potential barrier to nursing home research is the limited availability of research quality data in electronic form. We describe a case study of converting electronic health data from five skilled nursing facilities to a research quality longitudinal dataset by means of open-source tools produced by the Observational Health Data Sciences and Informatics (OHDSI) collaborative. METHODS: The Long-Term Care Minimum Data Set (MDS), drug dispensing, and fall incident data from five SNFs were extracted, translated, and loaded into version 4 of the OHDSI common data model...
2016: EGEMS
https://www.readbyqxmd.com/read/27875988/common-data-elements-for-secondary-use-of-electronic-health-record-data-for-clinical-trial-execution-and-serious-adverse-event-reporting
#3
Philipp Bruland, Mark McGilchrist, Eric Zapletal, Dionisio Acosta, Johann Proeve, Scott Askin, Thomas Ganslandt, Justin Doods, Martin Dugas
BACKGROUND: Data capture is one of the most expensive phases during the conduct of a clinical trial and the increasing use of electronic health records (EHR) offers significant savings to clinical research. To facilitate these secondary uses of routinely collected patient data, it is beneficial to know what data elements are captured in clinical trials. Therefore our aim here is to determine the most commonly used data elements in clinical trials and their availability in hospital EHR systems...
November 22, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27866956/accuracy-and-completeness-of-drug-information-in-wikipedia-medication-monographs
#4
Timothy Reilly, William Jackson, Victoria Berger, Danielle Candelario
OBJECTIVES: The primary objective of this study was to determine the accuracy and completeness of drug information on Wikipedia and Micromedex compared with U.S. Food and Drug Administration-approved U.S. product inserts. METHODS: The top 10 brand and top 10 generic medications from the 2012 Institute for Health Informatics' list of top 200 drugs were selected for evaluation. Wikipedia medication information was evaluated and compared with Micromedex in 7 sections of drug information; the U...
November 17, 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27862888/brometh-methodology-to-design-safe-reconfigurable-medical-robotic-systems
#5
Mohamed Oussama Ben Salem, Olfa Mosbahi, Mohamed Khalgui, Zied Jlalia, Georg Frey, Mahmoud Smida
BACKGROUND: This research paper deals with the development of a medical robotized control system for supracondylar humeral fracture treatment. Concurrent access to shared resources and applying reconfiguration scenarios can jeopardize the safety of the system. METHODS: A new methodology is proposed in this paper, termed BROMETH, to guarantee the safety of such critical systems from their specification to their deployment, and passing through certification and implementation...
November 14, 2016: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/27847328/methodological-framework-for-evaluating-clinical-processes-a-cognitive-informatics-perspective
#6
Thomas Kannampallil, Joanna Abraham, Vimla L Patel
We propose a methodological framework for evaluating clinical cognitive activities in complex real-world environments that provides a guiding framework for characterizing the patterns of activities. This approach, which we refer to as a process-based approach, is particularly relevant to cognitive informatics (CI) research-an interdisciplinary domain utilizing cognitive approaches in the study of computing systems and applications-as it provides new ways for understanding human information processing, interactions, and behaviors...
November 12, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27830261/nursing-informatics-certification-worldwide-history-pathway-roles-and-motivation
#7
Mollie R Cummins, Adi V Gundlapalli, Aditya V Gundlapalli, Peter Murray, Hyeoun-Ae Park, Christoph U Lehmann
INTRODUCTION: Official recognition and certification for informatics professionals are essential aspects of workforce development. OBJECTIVE: To describe the history, pathways, and nuances of certification in nursing informatics across the globe; compare and contrast those with board certification in clinical informatics for physicians. METHODS: (1) A review of the representative literature on informatics certification and related competencies for nurses and physicians, and relevant websites for nursing informatics associations and societies worldwide; (2) similarities and differences between certification processes for nurses and physicians, and (3) perspectives on roles for nursing informatics professionals in healthcare Results: The literature search for 'nursing informatics certification' yielded few results in PubMed; Google Scholar yielded a large number of citations that extended to magazines and other non-peer reviewed sources...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27830254/clinical-research-informatics-contributions-from-2015
#8
C Daniel, R Choquet
OBJECTIVES: To summarize key contributions to current research in the field of Clinical Research Informatics (CRI) and to select best papers published in 2015. METHOD: A bibliographic search using a combination of MeSH and free terms search over PubMed on Clinical Research Informatics (CRI) was performed followed by a double-blind review in order to select a list of candidate best papers to be then peer-reviewed by external reviewers. A consensus meeting between the two section editors and the editorial team was finally organized to conclude on the selection of best papers...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27830253/clinical-research-informatics-for-big-data-and-precision-medicine
#9
C Weng, M G Kahn
OBJECTIVES: To reflect on the notable events and significant developments in Clinical Research Informatics (CRI) in the year of 2015 and discuss near-term trends impacting CRI. METHODS: We selected key publications that highlight not only important recent advances in CRI but also notable events likely to have significant impact on CRI activities over the next few years or longer, and consulted the discussions in relevant scientific communities and an online living textbook for modern clinical trials...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27830252/findings-from-the-section-on-bioinformatics-and-translational-informatics
#10
H Dauchel, T Lecroq
OBJECTIVES: To summarize excellent current research and propose a selection of best papers published in 2015 in the field of Bioinformatics and Translational Informatics with application in the health domain and clinical care. METHOD: We provide a synopsis of the articles selected for the IMIA Yearbook 2016, from which we attempt to derive a synthetic overview of current and future activities in the field. As last year, a first step of selection was performed by querying MEDLINE with a list of MeSH descriptors completed by a list of terms adapted to the section...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27830249/efficient-results-in-semantic-interoperability-for-health-care-findings-from-the-section-on-knowledge-representation-and-management
#11
L F Soualmia, J Charlet
OBJECTIVES: To summarize excellent current research in the field of Knowledge Representation and Management (KRM) within the health and medical care domain. METHOD: We provide a synopsis of the 2016 IMIA selected articles as well as a related synthetic overview of the current and future field activities. A first step of the selection was performed through MEDLINE querying with a list of MeSH descriptors completed by a list of terms adapted to the KRM section. The second step of the selection was completed by the two section editors who separately evaluated the set of 1,432 articles...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27830243/new-problems-new-solutions-a-never-ending-story-findings-from-the-clinical-information-systems-perspective-for-2015
#12
W O Hackl, T Ganslandt
OBJECTIVE: To summarize recent research and to propose a selection of best papers published in 2015 in the field of Clinical Information Systems (CIS). METHOD: The query which had been used last year to retrieve articles for the CIS section of the IMIA Yearbook of Medical Informatics 2015 was refined. It again aimed at identifying relevant publications in the field of CIS and comprised search terms from the Medical Subject Headings (MeSH) catalog as well as additional free text search terms from PubMed and Web of Science...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27830226/new-unintended-adverse-consequences-of-electronic-health-records
#13
D F Sittig, A Wright, J Ash, H Singh
Although the health information technology industry has made considerable progress in the design, development, implementation, and use of electronic health records (EHRs), the lofty expectations of the early pioneers have not been met. In 2006, the Provider Order Entry Team at Oregon Health & Science University described a set of unintended adverse consequences (UACs), or unpredictable, emergent problems associated with computer-based provider order entry implementation, use, and maintenance. Many of these originally identified UACs have not been completely addressed or alleviated, some have evolved over time, and some new ones have emerged as EHRs became more widely available...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27815527/development-and-application-of-a-clinical-microsystem-simulation-methodology-for-human-factors-based-research-of-alarm-fatigue
#14
Leo Kobayashi, John W Gosbee, Derek L Merck
OBJECTIVES: (1) To develop a clinical microsystem simulation methodology for alarm fatigue research with a human factors engineering (HFE) assessment framework and (2) to explore its application to the comparative examination of different approaches to patient monitoring and provider notification. BACKGROUND: Problems with the design, implementation, and real-world use of patient monitoring systems result in alarm fatigue. A multidisciplinary team is developing an open-source tool kit to promote bedside informatics research and mitigate alarm fatigue...
November 3, 2016: HERD
https://www.readbyqxmd.com/read/27807750/biobanks-and-their-clinical-application-and-informatics-challenges
#15
Lan Yang, Yalan Chen, Chunjiang Yu, Bairong Shen
Biobanks are one of the most important biomedical research resources and contribute to the development of biomarker detection, molecular diagnosis, translational medicine, and multidisciplinary disease research, as well as studies of interactions between genetic and environmental or lifestyle factors. Aiming for the wide clinical application of biobanks, biobanking efforts have recently switched from a focus on accumulating samples to both formalizing and sustaining collections in light of the rapid progress in the fields of personalized medicine and bioinformatics analysis...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27791269/proteomics-applications-in-dental-derived-stem-cells
#16
REVIEW
Jie Li, Weidong Tian, Jinlin Song
At present, the existence of a variety of dental derived stem cells has been documented. These cells displayed promising clinical application potential not only for teeth and its surrounding tissue regeneration, but also for other tissues, such as nerve and bone regeneration. Proteomics is an unbiased, global informatics tool that provides information on all protein expression levels as well as post-translational modification in cells or tissues and is applicable to dental derived stem cells research. Over the last decade, considerable progress has been made to study the global proteome, secrotome, and membrane proteome of dental derived stem cells...
October 28, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27782291/person-generated-data-in-self-quantification-a-health-informatics-research-program
#17
Kathleen Gray, Fernando J Martin-Sanchez, Guillermo H Lopez-Campos, Manal Almalki, Mark Merolli
OBJECTIVES: The availability of internet-connected mobile, wearable and ambient consumer technologies, direct-to-consumer e-services and peer-to-peer social media sites far outstrips evidence about the efficiency, effectiveness and efficacy of using them in healthcare applications. The aim of this paper is to describe one approach to build a program of health informatics research, so as to generate rich and robust evidence about health data and information processing in self-quantification and associated healthcare and health outcomes...
October 26, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27754282/hw-04-3-global-network-for-her-based-big-data-analysis
#18
Peter Rijnbeek
Massive numbers of electronic health records are currently being collected globally, including structured data in the form of diagnoses, medications, laboratory test results, and unstructured data contained in clinical narratives. This opens unprecedented possibilities for research and ultimately patient care. However, actual use of these databases in a multi-center study is severely hampered by a variety of challenges, e.g., each database has a different database structure and uses different terminology systems...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754281/hw-04-1-usefulness-of-big-data-in-clinical-research
#19
Rae Woong Park
Big data indicates the large and ever-increasing volumes of data adhere to the following 4Vs: volume (ever-increasing amount), velocity (quickly generated), variety (many different types), veracity (from trustable sources). The last decade has seen huge advances in the amount of data we routinely generate and collect in pretty much everything we do, as well as our ability to use technology to analyze and understand it. The routine operation of modern health care systems also produces an abundance of electronically stored data on an ongoing basis as a byproduct of clinical practice...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27742664/a-bioimage-informatics-platform-for-high-throughput-embryo-phenotyping
#20
James M Brown, Neil R Horner, Thomas N Lawson, Tanja Fiegel, Simon Greenaway, Hugh Morgan, Natalie Ring, Luis Santos, Duncan Sneddon, Lydia Teboul, Jennifer Vibert, Gagarine Yaikhom, Henrik Westerberg, Ann-Marie Mallon
High-throughput phenotyping is a cornerstone of numerous functional genomics projects. In recent years, imaging screens have become increasingly important in understanding gene-phenotype relationships in studies of cells, tissues and whole organisms. Three-dimensional (3D) imaging has risen to prominence in the field of developmental biology for its ability to capture whole embryo morphology and gene expression, as exemplified by the International Mouse Phenotyping Consortium (IMPC). Large volumes of image data are being acquired by multiple institutions around the world that encompass a range of modalities, proprietary software and metadata...
October 14, 2016: Briefings in Bioinformatics
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