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Clinical research informatics

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https://www.readbyqxmd.com/read/29759958/data-access-and-usage-practices-across-a-cohort-of-researchers-at-a-large-tertiary-pediatric-hospital-qualitative-survey-study
#1
Hoi Ki Kiki Ho, Matthias Görges, Elodie Portales-Casamar
BACKGROUND: Health and health-related data collected as part of clinical care is a foundational component of quality improvement and research. While the importance of these data is widely recognized, there are many challenges faced by researchers attempting to use such data. It is crucial to acknowledge and identify barriers to improve data sharing and access practices and ultimately optimize research capacity. OBJECTIVE: To better understand the current state, explore opportunities, and identify barriers, an environmental scan of investigators at BC Children's Hospital Research Institute (BCCHR) was conducted to elucidate current local practices around data access and usage...
May 14, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29751857/residency-mini-fellowships-in-the-pgy-5-year-is-there-added-value
#2
Anuradha S Shenoy-Bhangle, Ronald L Eisenberg, Tabitha Fineberg, Priscilla J Slanetz
RATIONALE AND OBJECTIVES: With the restructuring of radiology board certification, many residencies created PGY-5 "mini-fellowships," during which residents spend focused time pursuing advanced subspecialty training or developing nonclinical skills in leadership, health policy and health-care economics, education, quality improvement, informatics, research, or global health. We surveyed graduates of an academic diagnostic radiology residency to assess the relative value and impact of PGY-5 mini-fellowships on career satisfaction and success...
June 2018: Academic Radiology
https://www.readbyqxmd.com/read/29741272/proton-pump-inhibitor-and-histamine-2-receptor-antagonist-use-and-risk-of-liver-cancer-in-two-population-based-studies
#3
K T Tran, Ú C McMenamin, B Hicks, P Murchie, A P Thrift, H G Coleman, L Iversen, B T Johnston, A J Lee, C R Cardwell
BACKGROUND: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) are commonly used. PPIs have been shown to promote liver cancer in rats; however, only one study has examined the association in humans. AIMS: To investigate PPIs and H2RAs and risk of primary liver cancer in two large independent study populations. METHODS: We conducted a nested case-control study within the Primary Care Clinical Informatics Unit (PCCIU) database in which up to five controls were matched to cases with primary liver cancer, recorded by General Practitioners...
May 9, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29727589/genome-sequencing-in-the-clinic-the-past-present-and-future-of-genomic-medicine
#4
Jeremy W Prokop, Thomas May, Kim Strong, Stephanie M Bilinovich, Caleb Bupp, Surender Rajasekaran, Elizabeth A Worthey, Jozef Lazar
Genomic sequencing has undergone massive expansion in the past ten years, opening the door from being a rarely used research tool into an approach that has broad applications in a clinical setting. From rare disease to cancer, genomics is transforming our knowledge of biology. The transition from targeted gene sequencing, to whole exome sequencing, to whole genome sequencing has only been made possible due to rapid advancements in technologies and informatics that have plummeted the cost per base of DNA sequencing and analysis...
May 4, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29726441/how-to-measure-physical-motion-and-the-impact-of-individualized-feedback-in-the-field-of-rehabilitation-of-geriatric-trauma-patients
#5
Amelie Altenbuchner, Sonja Haug, Rainer Kretschmer, Karsten Weber
BACKGROUND: This preparatory study accelerates an implementation of individualized monitoring and feedback of physical motion using conventional motion trackers in the rehabilitation process of geriatric trauma patients. Regaining mobility is accompanied with improved quality of life in persons of very advanced age recovering from fragility fractures. OBJECTIVES: Quantitative survey of regaining physical mobility provides recommendations for action on how to use motion trackers effectively in a clinical geriatric setting...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29710185/accuracy-and-reliability-of-eye-based-vs-quadrant-based-diagnosis-of-plus-disease-in-retinopathy-of-prematurity
#6
Sang Jin Kim, J Peter Campbell, Jayashree Kalpathy-Cramer, Susan Ostmo, Karyn E Jonas, Dongseok Choi, R V Paul Chan, Michael F Chiang
Importance: Presence of plus disease in retinopathy of prematurity is the most critical element in identifying treatment-requiring disease. However, there is significant variability in plus disease diagnosis. In particular, plus disease has been defined as 2 or more quadrants of vascular abnormality, and it is not clear whether it is more reliably and accurately diagnosed by eye-based assessment of overall retinal appearance or by quadrant-based assessment combining grades of 4 individual quadrants...
April 26, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29691211/developing-a-third-party-analytics-application-using-australia-s-national-personal-health-records-system-case-study
#7
Niranjan Bidargaddi, Yasmin van Kasteren, Peter Musiat, Michael Kidd
BACKGROUND: My Health Record (MyHR) is Australia's national electronic health record (EHR) system. Poor usability and functionality have resulted in low utility, affecting enrollment and participation rates by both patients and clinicians alike. Similar to apps on mobile phone app stores, innovative third-party applications of MyHR platform data can enhance the usefulness of the platform, but there is a paucity of research into the processes involved in developing third-party applications that integrate and use data from EHR systems...
April 24, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29678669/using-big-data-in-oncology-to-prospectively-impact-clinical-patient-care-a-proof-of-concept-study
#8
Vérène Dougoud-Chauvin, Jae Jin Lee, Edgardo Santos, Vonetta L Williams, Nicolò M L Battisti, Kavita Ghia, Marina Sehovic, Cortlin Croft, Jongphil Kim, Lodovico Balducci, Julie A Kish, Martine Extermann
OBJECTIVE: Big Data is widely seen as a major opportunity for progress in the practice of personalized medicine, attracting the attention from medical societies and presidential teams alike as it offers a unique opportunity to enlarge the base of evidence, especially for older patients underrepresented in clinical trials. This study prospectively assessed the real-time availability of clinical cases in the Health & Research Informatics Total Cancer Care™ (TCC) database matching community patients with cancer, and the impact of such a consultation on treatment...
April 17, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29678086/implementing-systems-medicine-a-medical-informatics-perspective
#9
Matthias Ganzinger, Matthias Gietzelt, Christian Karmen, Blanca Flores, Petra Knaup
Systems medicine is a paradigm for translating in silico methods developed for modelling biological systems into the field of medicine. Such approaches rely on the integration of as many data sources as possible, both in the dimension of disease knowledge and patient data. This is a challenging task that can only be implemented in clinical routine with the help of suitable information technology from the field of Medical Informatics. For the research project "Clinically-applicable, omics-based assessment of survival, side effects, and targets in multiple myeloma" (CLIOMMICS) we developed a prototypical systems medicine application system...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677992/biomedical-informatics-how-to-choose-the-best-tool-for-each-task
#10
Fábio Maia, Luís Bastião Silva, José Luís Oliveira
The ever-increasing number of bioinformatics software tools that are publicly available, is leading to greater expectations about its regular use in clinical practice. However, from the end-users' perspective, they face many time the challenge of choosing the right tool for each task, from a panoply of solutions that have been developed over the years. In this paper, we propose a benchmarking methodology, based on a set of performance indicators, which can be used to identify the best methods and tools for each particular use case, both in research as in clinical practice...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677988/gaining-insights-on-nasopharyngeal-carcinoma-treatment-outcome-using-clinical-data-mining-techniques
#11
A Ammar Ghaibeh, Asem Kasem, Xun Jin Ng, Hema Latha Krishna Nair, Jun Hirose, Vinesh Thiruchelvam
The analysis of Electronic Health Records (EHRs) is attracting a lot of research attention in the medical informatics domain. Hospitals and medical institutes started to use data mining techniques to gain new insights from the massive amounts of data that can be made available through EHRs. Researchers in the medical field have often used descriptive statistics and classical statistical methods to prove assumed medical hypotheses. However, discovering new insights from large amounts of data solely based on experts' observations is difficult...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29656848/the-discipline-of-epidemiology-engaging-in-the-full-breadth-of-population-health-science
#12
Harold I Feldman
This address was delivered by Harold I. Feldman, MD, MSCE, at the Annual Meeting of the American College of Epidemiology in New Orleans, Louisiana, on September 26, 2017. Dr. Feldman is George S. Pepper Professor of Public Health and Preventive Medicine, Professor of Epidemiology and Medicine, and Chair, Department of Biostatistics, Epidemiology, and Informatics at the Perelman School of Medicine at the University of Pennsylvania. He is recognized nationally and internationally for his expertise in kidney disease epidemiology...
March 21, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29629054/health-information-technology-in-ambulatory-care-in-a-developing-country
#13
Ghasem Deimazar, Mehdi Kahouei, Afsane Zamani, Zahra Ganji
Background: Physicians need to apply new technologies in ambulatory care. At present, with regard to the extended use of information technology in other departments in Iran it has yet to be considerably developed by physicians and clinical technicians in the health department. Objective: To determine the rate of use of health information technology in the clinics of specialist- and subspecialist physicians in Semnan city, Iran. Methods: This was a 2016 cross-sectional study conducted in physicians' offices of Semnan city in Iran...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29621387/diagnostic-accuracy-of-ophthalmoscopy-vs-telemedicine-in-examinations-for-retinopathy-of-prematurity
#14
Hilal Biten, Travis K Redd, Chace Moleta, J Peter Campbell, Susan Ostmo, Karyn Jonas, R V Paul Chan, Michael F Chiang
Importance: Examinations for retinopathy of prematurity (ROP) are typically performed using binocular indirect ophthalmoscopy. Telemedicine studies have traditionally assessed the accuracy of telemedicine compared with ophthalmoscopy as a criterion standard. However, it is not known whether ophthalmoscopy is truly more accurate than telemedicine. Objective: To directly compare the accuracy and sensitivity of ophthalmoscopy vs telemedicine in diagnosing ROP using a consensus reference standard...
April 5, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29602312/clinical-natural-language-processing-in-languages-other-than-english-opportunities-and-challenges
#15
REVIEW
Aurélie Névéol, Hercules Dalianis, Sumithra Velupillai, Guergana Savova, Pierre Zweigenbaum
BACKGROUND: Natural language processing applied to clinical text or aimed at a clinical outcome has been thriving in recent years. This paper offers the first broad overview of clinical Natural Language Processing (NLP) for languages other than English. Recent studies are summarized to offer insights and outline opportunities in this area. MAIN BODY: We envision three groups of intended readers: (1) NLP researchers leveraging experience gained in other languages, (2) NLP researchers faced with establishing clinical text processing in a language other than English, and (3) clinical informatics researchers and practitioners looking for resources in their languages in order to apply NLP techniques and tools to clinical practice and/or investigation...
March 30, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29596094/database-quality-and-access-issues-relevant-to-research-using-anesthesia-information-management-system-data
#16
Richard H Epstein, Franklin Dexter
For this special article, we reviewed the computer code, used to extract the data, and the text of all 47 studies published between January 2006 and August 2017 using anesthesia information management system (AIMS) data from Thomas Jefferson University Hospital (TJUH). Data from this institution were used in the largest number (P = .0007) of papers describing the use of AIMS published in this time frame. The AIMS was replaced in April 2017, making this finite sample finite. The objective of the current article was to identify factors that made TJUH successful in publishing anesthesia informatics studies...
March 27, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29590633/disease-ontology-improving-and-unifying-disease-annotations-across-species
#17
Susan M Bello, Mary Shimoyama, Elvira Mitraka, Stanley J F Laulederkind, Cynthia L Smith, Janan T Eppig, Lynn M Schriml
Model organisms are vital to uncovering the mechanisms of human disease and developing new therapeutic tools. Researchers collecting and integrating relevant model organism and/or human data often apply disparate terminologies (vocabularies and ontologies), making comparisons and inferences difficult. A unified disease ontology is required that connects data annotated using diverse disease terminologies, and in which the terminology relationships are continuously maintained. The Mouse Genome Database (MGD, http://www...
March 12, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29568713/translating-new-science-into-the-drug-review-process-the-us-fda-s-division-of-applied-regulatory-science
#18
Rodney Rouse, Naomi Kruhlak, James Weaver, Keith Burkhart, Vikram Patel, David G Strauss
In 2011, the US Food and drug Administration (FDA) developed a strategic plan for regulatory science that focuses on developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products. In line with this, the Division of Applied Regulatory Science was created to move new science into the Center for Drug Evaluation and Research (CDER) review process and close the gap between scientific innovation and drug review. The Division, located in the Office of Clinical Pharmacology, is unique in that it performs mission-critical applied research and review across the translational research spectrum including in vitro and in vivo laboratory research, in silico computational modeling and informatics, and integrated clinical research covering clinical pharmacology, experimental medicine, and postmarket analyses...
March 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29566172/biomedical-informatics-and-machine-learning-for-clinical-genomics
#19
James Diao, Isaac S Kohane, Arjun K Manrai
While tens of thousands of pathogenic variants are used in the myriad clinical applications of genomics, there remains limited quantitative risk information (i.e. penetrance) or consensus about the clinical utility of the majority of extant variants and tests. Relatedly, with the rising demand for genetic counseling, there is a need for computational approaches that scale the ability of counselors to interpret new and existing variants, whether by automating the determination of pathogenicity or filtering variants too common in the general population to be sufficiently penetrant...
March 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29544642/characterization-of-the-ovarian-tumor-peptidome
#20
Tao Liu, Karin D Rodland, Richard D Smith
Aberrant degradation of proteins is associated with many pathological states, including cancers. Mass spectrometric analysis of the tumor peptidome has the potential to provide biological insights on proteolytic processing in cancer. However, attempts to use the tumors peptidome information in cancer research have been fairly limited to date, largely due to the lack of effective approaches for robust peptidomics identification and quantification, and the prevalence of confounding factors and biases associated with sample handling and processing...
2018: Vitamins and Hormones
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