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https://www.readbyqxmd.com/read/29346735/mechanisms-of-modulation-of-calcium-phosphate-pathological-mineralization-by-mobile-and-immobile-small-molecule-inhibitors
#1
Meng Li, Jing Zhang, Lijun Wang, Baoshan Wang, Christine V Putnis
Potential pathways for inhibiting crystal growth are either via disrupting local microenvironments surrounding crystal-solution interfaces or physically blocking solute molecule attachment. However, the actual mode of inhibition may be more complicated due to the characteristic time scale for the inhibitor adsorption and relaxation to a well-bound state at crystal surfaces. Here we demonstrate the role of citrate (CA) and hydroxycitrate (HCA) in brushite (DCPD, CaHPO4·2H2O) crystallization over a broad range of both inhibitor concentrations and supersaturations by in situ atomic force microscopy (AFM)...
January 18, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29346663/resident-participation-in-neighbourhood-audit-tools-a-scoping-review
#2
Aafke C L Hofland, Jeroen Devilee, Elise van Kempen, Lea den Broeder
Background: Healthy urban environments require careful planning and a testing of environmental quality that goes beyond statutory requirements. Moreover, it requires the inclusion of resident views, perceptions and experiences that help deepen the understanding of local (public health) problems. To facilitate this, neighbourhoods should be mapped in a way that is relevant to them. One way to do this is participative neighbourhood auditing. This paper provides an insight into availability and characteristics of participatory neighbourhood audit instruments...
February 1, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29346643/genetic-characterization-of-a-vang-type-vancomycin-resistant-enterococcus-faecium-clinical-isolate
#3
Mohamed Sassi, François Guérin, Léonie Lesec, Christophe Isnard, Marguerite Fines-Guyon, Vincent Cattoir, Jean-Christophe Giard
Objectives: To characterize, phenotypically and genotypically, the first Enterococcus faecium clinical isolate harbouring a vanG operon. Methods: The antibiotic resistance profile of E. faecium 16-346 was determined and its whole genome sequenced using PacBio technology. Attempts to transfer vancomycin resistance by filter mating were performed and the inducibility of expression of the vanG operon was studied by reverse-transcription quantitative PCR (RT-qPCR) in the presence or absence of subinhibitory concentrations of vancomycin...
January 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29346586/plasflow-predicting-plasmid-sequences-in-metagenomic-data-using-genome-signatures
#4
Pawel S Krawczyk, Leszek Lipinski, Andrzej Dziembowski
Plasmids are mobile genetics elements that play an important role in the environmental adaptation of microorganisms. Although plasmids are usually analyzed in cultured microorganisms, there is a need for methods that allow for the analysis of pools of plasmids (plasmidomes) in environmental samples. To that end, several molecular biology and bioinformatics methods have been developed; however, they are limited to environments with low diversity and cannot recover large plasmids. Here, we present PlasFlow, a novel tool based on genomic signatures that employs a neural network approach for identification of bacterial plasmid sequences in environmental samples...
January 13, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29346433/vault-rnas-partially-induces-drug-resistance-of-human-tumor-cells-mcf-7-by-binding-to-the-rna-dna-binding-protein-psf-and-inducing-oncogene-gage6
#5
Jianjun Chen, Hui OuYang, Xuemei An, Shixi Liu
BACKGROUND: Vault is the largest nonicosahedral cytosolic nucleoprotein particle, which is widely involved in induction of chemoresistance and lead to failure in long-term chemotherapy. Vault contains three different major vault proteins (MVPs) and four vault RNAs paralogues (vtRNAs, vtRNA1-1, vtRNA1-2, vtRNA1-3 and vtRNA2-1). Disruption of the MVPs do not induce hypersensitivity while expression of vtRNAs contributes to cells' drug resistance, indicates that vtRNAs, but not MVPs play an important role in causing drug resistance...
2018: PloS One
https://www.readbyqxmd.com/read/29346410/an-evaluation-of-multi-probe-locality-sensitive-hashing-for-computing-similarities-over-web-scale-query-logs
#6
Graham Cormode, Anirban Dasgupta, Amit Goyal, Chi Hoon Lee
Many modern applications of AI such as web search, mobile browsing, image processing, and natural language processing rely on finding similar items from a large database of complex objects. Due to the very large scale of data involved (e.g., users' queries from commercial search engines), computing such near or nearest neighbors is a non-trivial task, as the computational cost grows significantly with the number of items. To address this challenge, we adopt Locality Sensitive Hashing (a.k.a, LSH) methods and evaluate four variants in a distributed computing environment (specifically, Hadoop)...
2018: PloS One
https://www.readbyqxmd.com/read/29346321/new-control-paradigms-for-resources-saving-an-approach-for-mobile-robots-navigation
#7
Rafael Socas, Raquel Dormido, Sebastián Dormido
In this work, an event-based control scheme is presented. The proposed system has been developed to solve control problems appearing in the field of Networked Control Systems (NCS). Several models and methodologies have been proposed to measure different resources consumptions. The use of bandwidth, computational load and energy resources have been investigated. This analysis shows how the parameters of the system impacts on the resources efficiency. Moreover, the proposed system has been compared with its equivalent discrete-time solution...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346282/smartphone-based-cooperative-indoor-localization-with-rfid-technology
#8
Fernando Seco, Antonio R Jiménez
In GPS-denied indoor environments, localization and tracking of people can be achieved with a mobile device such as a smartphone by processing the received signal strength (RSS) of RF signals emitted from known location beacons (anchor nodes), combined with Pedestrian Dead Reckoning (PDR) estimates of the user motion. An enhacement of this localization technique is feasible if the users themselves carry additional RF emitters (mobile nodes), and the cooperative position estimates of a group of persons incorporate the RSS measurements exchanged between users...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346156/developing-a-mobile-app-for-prevention-and-treatment-of-pressure-injuries
#9
Geraldo Magela Salomé, Lydia Masako Ferreira
OBJECTIVE: This descriptive study describes the planning and development of a mobile application (app) for prevention and treatment of pressure injuries for use by providers in a university research center. The app delineates risk factors for pressure injury development, provides an evaluation of the wound, recommends wound cleansing procedures, performs pressure injury staging, and recommends treatment interventions. METHODS: A mobile app was developed using a contextualized instructional design, which involves a constructivist proposal and planning, developing, and applying specific didactic situations, thus incorporating mechanisms that favor contextualization...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29346081/reported-balance-confidence-and-movement-reinvestment-of-younger-knee-replacement-patients-are-more-like-younger-healthy-individuals-than-older-patients
#10
Brian D Street, Allan Adkin, William Gage
This study focused on differences between the rapidly growing younger (<65 years old) and older (>65 years old) total knee replacement (TKR) patients for measures of balance confidence, movement reinvestment, and functional mobility. Fifty-nine participants, including twenty-nine primary unilateral TKR patients (six months post-TKR) formed the four experimental groups: 1) Younger TKR Patient (YP), 2) Younger Control (YC), 3) Older TKR Patient (OP), and 4) Older Control (OC). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Oxford Knee Score (OKS), Activities-specific Balance Confidence scale (ABC), the Movement-Specific Reinvestment Scale (MSRS), and the Timed Up and Go (TUG) test were measured...
January 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29346038/smartphone-applications-for-amblyopia-treatment-a-review-of-current-apps-and-professional-involvement
#11
Nabin Paudel
OBJECTIVES: The objective of this study was to review games for amblyopia (lazy eye) that are commercially available in mobile applications (apps) stores and assess the involvement of eye care professionals in their development. MATERIALS AND METHODS: The Google play store and the Apple iTunes store were searched in July 2017 and updated in September 2017 for amblyopia games using the terms amblyopia, lazy eye, amblyopia therapy, lazy eye therapy, lazy eye exercises, amblyopia exercises, lazy eye games, and amblyopia games...
January 18, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29345996/delays-in-global-disease-outbreak-responses-lessons-from-h1n1-ebola-and-zika
#12
Steven J Hoffman, Sarah L Silverberg
In global disease outbreaks, there are significant time delays between the source of an outbreak and collective action. Some delay is necessary, but recent delays have been extended by insufficient surveillance capacity and time-consuming efforts to mobilize action. Three public health emergencies of international concern (PHEICs)-H1N1, Ebola, and Zika-allow us to identify and compare sources of delays and consider seven hypotheses about what influences the length of delays. These hypotheses can then motivate further research that empirically tests them...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29345949/surface-state-dynamics-dictating-transport-in-inas-nanowires
#13
David Lynall, Selvakumar V Nair, David Gutstein, Alexander Shik, Igor Savelyev, Marina Blumin, Harry E Ruda
Because of their high aspect ratio, nanostructures are particularly susceptible to effects from surfaces such as slow electron trapping by surface states. However, non-equilibrium trapping dynamics have been largely overlooked when considering transport in nanoelectronic devices. In this study, we demonstrate the profound influence of dynamic trapping processes on transport in InAs nanowires through an investigation of the hysteretic and time-dependent behaviour of the transconductance. We observe large densities (∽1013 cm-2) of slow surface traps and demonstrate the ability to control and permanently fix their occupation and charge through electrostatic manipulation by the gate potential followed by thermal deactivation by cryogenic cooling...
January 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29345751/first-evidence-of-freezing-tolerance-in-a-resurrection-plant-insights-into-molecular-mobility-and-zeaxanthin-synthesis-in-the-dark
#14
Beatriz Fernández-Marín, Gilbert Neuner, Edith Kuprian, Jose Manuel Laza, J I José Ignacio García-Plazaola, Amy Verhoeven
The photoprotective mechanisms of desiccation tolerance and freezing tolerance and their relation to molecular mobility (cell vitrification) were assessed in a single model: the exceptional subalpine and resurrection plant Ramonda myconi. Dehydrated leaves showed a drop in Fv /Fm accompanied by synthesis of zeaxanthin (Z), even in the dark, which was limited by cell vitrification after complete desiccation. The recovery of Fv /Fm after a severe drying treatment (7 d at 50% RH) confirmed the tolerance of R. myconi leaves to desiccation...
January 18, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29345750/mobility-trajectories-at-the-end-of-life-comparing-clinical-condition-and-latent-class-approaches
#15
June R Lunney, Steven M Albert, Robert Boudreau, Diane Ives, Suzanne Satterfield, Anne B Newman, Tamara Harris
OBJECTIVES: To assess mobility disability trajectories before death in a large sample of very old adults using two analytical approaches to determine how well they corresponded. DESIGN: Decedent sample from the Health, Aging and Body Composition (Health ABC) Study. Data were collected between 1997 and 2015. SETTING: Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Individuals randomly selected from well-functioning white Medicare beneficiaries and all black community residents meeting age criteria (70-79) (N = 3,075)...
January 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29345627/large-area-synthesis-and-photoelectric-properties-of-few-layered-mose-sub-2-sub-on-molybdenum-foils
#16
Zenghui Wu, Guoan Tai, Xufeng Wang, Tingsong Hu, Rui Wang, Wanlin Guo
Compared with MoS2 and WS2, the selenide analogues have narrower band gaps and higher electron mobilities, which make them more applicable to real electrical devices. Besides, few-layered metal selenides have higher electrical conductivity, carrier mobility and light absorption than the corresponding monolayers. However, the large-scale and high-quality growth of few-layered metal selenides remains a significant challenge. Here, we develop a facile method to grow large-area and highly-crystalline few-layered MoSe2 by directly selenizing the Mo foil surfaces at 550 oC within 60 min under ambient pressure...
January 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29345538/real-time-monitoring-of-nanoscale-tio2-concentration-by-spectrophotometry-implications-of-agglomeration-due-to-natural-organic-matter-and-multivalent-ions
#17
Andrew B Holmes, Frank X Gu
The study of the environmental fate of nanoscale TiO2 (n-TiO2) is a major recent research focus which requires a rapid and accurate on-site concentration determination method. Inductively coupled plasma mass spectroscopy (ICP-MS) has been the most widely used method for determining the concentration of n-TiO2 in environmental samples; however, poses many challenges, such as hazardous hydrofluoric acid pre-treatment and clear limitations in mobile on-site measurement and monitoring. This study demonstrates that industrial wastewater containing natural organic matter (NOM) can present a major challenge to the analysis of n-TiO2 by ICP-MS, and introduces a spectrophotometry technique that can be used as an alternative...
January 18, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29345471/synthesis-and-properties-of-dithiafulvenyl-functionalized-spiro-fluorene-9-9-xanthene-molecules
#18
Min Wu, Juan Li, Ruqin Zhang, Xia Tian, Zhaoxiang Han, Xiaoqing Lu, Kunpeng Guo, Zhike Liu, Zhongqiang Wang
Two spiroannulated molecular structures with dithiafulvenyl units functionalized at the 2,2',7,7'- (SFX-DTF1) and 2,3',6,'7- (SFX-DTF2) positions of a spiro[fluorene-9,9'-xanthene] core were synthesized. Studies revealed the hole mobility was significantly influenced by the dithiafulvenyl functionalized positions in the molecular structure. To explore their primary applications as hole-transporting materials in perovskite solar cells, SFX-DTF1-based devices exhibited a power conversion efficiency of 10.67% without the use of p-type dopants, yielding good air stability...
January 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29345430/wearable-wireless-tyrosinase-bandage-and-microneedle-sensors-toward-melanoma-screening
#19
Bianca Ciui, Aida Martin, Rupesh K Mishra, Barbara Brunetti, Tatsuo Nakagawa, Thomas J Dawkins, Mengjia Lyu, Cecilia Cristea, Robert Sandulescu, Joseph Wang
Wearable bendable bandage-based sensor and a minimally invasive microneedle biosensor are described toward rapid screening of skin melanoma. These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level...
January 18, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29345386/quinoline-flanked-diketopyrrolopyrrole-copolymers-breaking-through-electron-mobility-over-6-cm2-v-1-s-1-in-flexible-thin-film-devices
#20
Zhenjie Ni, Huanli Dong, Hanlin Wang, Shang Ding, Ye Zou, Qiang Zhao, Yonggang Zhen, Feng Liu, Lang Jiang, Wenping Hu
Herein, the design and synthesis of novel π-extended quinoline-flanked diketopyrrolopyrrole (DPP) [abbreviated as QDPP] motifs and corresponding copolymers named PQDPP-T and PQDPP-2FT for high performing n-type organic field-effect transistors (OFETs) in flexible organic thin film devices are reported. Serving as DPP-flankers in backbones, quinoline is found to effectively tune copolymer optoelectric properties. Compared with TDPP and pyridine-flanked DPP (PyDPP) analogs, widened bandgaps and strengthened electron deficiency are achieved...
January 18, 2018: Advanced Materials
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