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https://www.readbyqxmd.com/read/28110492/what-are-the-determinants-of-food-security-among-regional-and-remote-western-australian-children
#1
Stephanie L Godrich, Christina R Davies, Jill Darby, Amanda Devine
OBJECTIVE: To explore how determinants of food security affect children in regional and remote Western Australia (WA), across food availability, access and utilisation dimensions. METHODS: The Determinants of Food Security framework guided the thematic analysis (using NVivo 10) of semi-structured interviews with 20 key informants. RESULTS: Food availability factors included availability, price, promotion, quality, location of outlets and variety...
January 22, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28110333/requirements-for-septal-localization-and-chromosome-segregation-activity-of-the-dna-translocase-sfta-from-bacillus-subtilis
#2
Nina El Najjar, Christine Kaimer, Thomas Rösch, Peter L Graumann
Bacillus subtilis possesses 2 DNA translocases that affect late stages of chromosome segregation: SftA separates nonsegregated DNA prior to septum closure, while SpoIIIE rescues septum-entrapped DNA. We provide evidence that SftA is associated with the division machinery via a stretch of 47 amino acids within its N-terminus, suggesting that SftA is recruited by protein-protein interactions with a component of the division machinery. SftA was also recruited to mid-cell in the absence of its first 20 amino acids, which are proposed to contain a membrane-binding motif...
January 21, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28110286/exploring-the-role-of-pain-as-an-early-predictor-of-category-2-pressure-ulcers-a-prospective-cohort-study
#3
Isabelle L Smith, Sarah Brown, Elizabeth McGinnis, Michelle Briggs, Susanne Coleman, Carol Dealey, Delia Muir, E Andrea Nelson, Rebecca Stevenson, Nikki Stubbs, Lyn Wilson, Julia M Brown, Jane Nixon
OBJECTIVE: To explore pressure area related pain as a predictor of category ≥2 pressure ulcer (PU) development. DESIGN: Multicentre prospective cohort study. SETTING: UK hospital and community settings. PARTICIPANTS INCLUSION: Consenting acutely ill patients aged ≥18 years, defined as high risk (Braden bedfast/chairfast AND completely immobile/very limited mobility; pressure area related pain or; category 1 PU)...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28110221/simultaneous-determination-of-eight-flavonoids-in-plasma-using-lc-ms-ms-and-application-to-a-pharmacokinetic-study-after-oral-administration-of-pollen-typhae-extract-to-rats
#4
Xie-An Yu, John Teye Azietaku, Jin Li, Jun Cao, Mingrui An, Jun He, Xiu-Mei Gao, Yan-Xu Chang
A sensitive, reliable and validated LC-MS/MS method was developed to determine the presence of eight flavonoids (catechin, typhaneoside, isorhamnetin-3-O-neohesperidoside, astragalin, isorhamnetin-3-O-β-d-glucoside, naringenin, kaempferol and isorhamnetin) in rat plasma. Puerarin was selected as the internal standard. Precipitation of the protein method with acetonitrile was used to extract these flavonoids from the rat plasma samples. The analysis was carried out on an Eclipse plus C18 column (4.6 mm×100mm, 1...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28110166/lc-method-development-for-the-quantification-of-neuromedin-like-peptides-emphasis-on-column-choice-and-mobile-phase-composition
#5
Yannick Van Wanseele, Johan Viaene, Leslie Van den Borre, Kathleen Dewachter, Yvan Vander Heyden, Ilse Smolders, Ann Van Eeckhaut
In this study, the separation of four neuromedin-like peptides is investigated on four different core-shell stationary phases. Moreover, the effect of the mobile phase composition, i.e. organic modifier (acetonitrile and methanol) and additive (trifluoroacetic acid, formic acid, acetic acid, ammonium formate and ammonium acetate) on the chromatographic performance is studied. An improvement in chromatographic performance is observed when using the ammonium salt instead of its corresponding acid as additive, except for the column containing a positively charged surface (C18+)...
January 11, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28110063/curcumin-ameliorates-liver-damage-and-progression-of-nash-in-nash-hcc-mouse-model-possibly-by-modulating-hmgb1-nf-%C3%AE%C2%BAb-translocation
#6
Rejina Afrin, Somasundaram Arumugam, Azizur Rahman, Mir Imam Ibne Wahed, Vengadeshprabhu Karuppagounder, Meilei Harima, Hiroshi Suzuki, Shizuka Miyashita, Kenji Suzuki, Hiroyuki Yoneyama, Kazuyuki Ueno, Kenichi Watanabe
Curcumin, a phenolic compound, has a wide spectrum of therapeutic effects such as antitumor, anti-inflammatory, anti-cancer and so on. The study aimed to investigate the underlying mechanisms of curcumin to protect liver damage and progression of non-alcoholic steatohepatitis (NASH) in a novel NASH-hepatocellular carcinoma (HCC) mouse model. To induce this model neonatal C57BL/6J male mice were exposed to low-dose streptozotocin and were fed a high-fat diet (HFD) from the age of 4weeks to 14weeks. Curcumin was given at 100mg/kg dose daily by oral gavage started at the age of 10weeks and continued until 14weeks along with HFD feeding...
January 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28110062/metal-free-hybrids-of-graphitic-carbon-nitride-and-nanodiamonds-for-photoelectrochemical-and-photocatalytic-applications
#7
Li Zhou, Huayang Zhang, Xiaochen Guo, Hongqi Sun, Shaomin Liu, Moses O Tade, Shaobin Wang
Graphitic carbon nitride (g-C3N4) has been considered as a metal-free, cost-effective, eco-friendly and efficient catalyst for various photoelectrochemical applications. However, compared to conventional metal-based photocatalysts, its photocatalytic activity is still low because of the low mobility of carriers restricted by the polymer nature. Herein, a series of hybrids of g-C3N4 (GCN) and nanodiamonds (NDs) were synthesized using a solvothermal method. The photoelectrochemical performance and photocatalytic efficiency of the GCN/NDs were investigated by means of the generation of photocurrent and photodegradation of methylene blue (MB) solutions under UV-visible light irradiations...
January 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28109883/probing-transport-of-charged-%C3%AE-lactamase-inhibitors-through-ompc-a-membrane-channel-from-e-coli
#8
Ishan Ghai, Mathias Winterhalter, Richard Wagner
One of the major causes of antibiotic resistance in the Gram-negative bacteria is the low permeability across the outer membrane. Currently a main bottleneck in the development of effective antibiotics is the lack of a general method to quantify permeation which would allow screening for optimal scaffolds. Here, we present a permeation assay based on conventional electrophysiology. The method mainly involves application of concentration gradients of charged molecules with different electrophoretic mobilities through a membrane channel...
January 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28109824/expanding-the-actions-of-cortisol-and-corticosterone-in-wild-vertebrates-a-necessary-step-to-overcome-the-emerging-challenges
#9
REVIEW
Federico Vera, Roxana Zenuto, C Daniel Antenucci
We conducted a review of scientific articles published between 2000 and 2014 and evaluated how frequently various aspects of cortisol and corticosterone (CORT) actions have been considered in studies on wild vertebrates. Results show that (1) the notion that CORT are stress-responsive hormones is central in our theoretical frameworks and it is reflected by the fact that several articles refer to CORT as "stress hormones". (2) The large majority of studies do not contemplate the possibility of decrease and no change in CORT levels in response to chronic stressors...
January 18, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28109698/microbubble-assisted-ultrasound-induced-transient-phosphatidylserine-translocation
#10
Jean-Michel Escoffre, Marc Derieppe, Bart Lammertink, Clemens Bos, Chrit Moonen
Microbubble-assisted ultrasound (sonopermeabilization) results in reversible permeabilization of the plasma membrane of cells. This method is increasingly used in vivo because of its potential to deliver therapeutic molecules with limited cell damage. Nevertheless, the effects of sonopermeabilization on the plasma membrane remain not fully understood. We investigated the influence of sonopermeabilization on the transverse mobility of phospholipids, especially on phosphatidylserine (PS) externalization. We performed studies using optical imaging with Annexin V and FM1-43 probes to monitor PS externalization of rat glioma C6 cells...
January 18, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28109505/results-of-vsb-implantation-at-the-short-process-of-the-incus-in-children-with-ear-atresia
#11
Charlotte Célérier, Briac Thierry, Cyrille Coudert, Marion Blanchard, Natalie Loundon, Erea Noel Garabédian, Françoise Denoyelle
OBJECTIVE(S): To describe a new and more simple surgical procedure for implanting the Vibrant Soundbridge (VSB) on the short process of the incus in children with ear atresia and atretic plate and present the audiometric results. METHODS: Since 2014, pre- and post-operative audiometric tests with tonal and vocal audiometryat the maximal follow up, respectively 33, 22 and 12 months were performed after VSB implantation at the ENT department, Necker Enfants Malades Hospital, Paris, France...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28109495/swallowing-function-in-pediatric-patients-with-bilateral-vocal-fold-immobility
#12
Jeffrey Hsu, Kathleen M Tibbetts, Derek Wu, Michel Nassar, Melin Tan
INTRODUCTION: Infants with bilateral vocal fold immobility (BVFI) often have poor swallow function in addition to potential airway compromise. While there are several reports on BVFI and its effect on patients' airway status, little is known about long term swallow function. OBJECTIVES: We aim to characterize the swallowing function over time in pediatric patients with bilateral vocal fold immobility. METHODS: A retrospective review of medical records of infants diagnosed with BVFI at a tertiary care children's hospital between 2005 and 2014 was conducted...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28109394/lead-sparing-tricuspid-valve-repair-damaged-by-pacemaker-lead
#13
Kasra Shaikhrezai, Aleksandra Bartnik, Maziar Khorsandi, Steven Hunter
Permanent pacemaker lead may damage the tricuspid valve in various ways, causing severe tricuspid valve regurgitation. The perforation of posterior papillary muscle is an uncommon complication caused by the lead. We describe a lead-sparing tricuspid valve repair in which the lead extraction was not an option. The papillary muscle containing the lead was fully mobilized to release the adherent leaflets. The repair was completed by commissuroplasty as well as ring annuloplasty, leaving the lead inside the implanted ring...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109298/neuroregenerative-potential-of-intravenous-g-csf-and-autologous-peripheral-blood-stem-cells-in-children-with-cerebral-palsy-a-randomized-double-blind-cross-over-study
#14
Wee-Jin Rah, Young-Ho Lee, Jin-Hwa Moon, Hyun-Ju Jun, Hye-Ryeong Kang, Hani Koh, Hye Jung Eom, Ji Young Lee, Young Jun Lee, Ji Young Kim, Yun-Young Choi, Kyeongil Park, Mi Jung Kim, Seung-Hyun Kim
OBJECTIVE: We performed a randomized, double-blind, cross-over study to assess the neuroregenerative potential of intravenous granulocyte colony-stimulating factor (G-CSF) followed by infusion of mobilized peripheral blood mononuclear cells (mPBMCs) in children with cerebral palsy (CP). METHODS: Children with non-severe CP were enrolled in this study. G-CSF was administered for 5 days, then mPBMCs were collected by apheresis and cryopreserved. One month later (M1), recipients were randomized to receive either mPBMCs or a placebo infusion, and these treatment groups were switched at 7 months (M7) and observed for another 6 months (M13)...
January 21, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28109267/the-use-of-physical-restraints-in-long-term-care-in-spain-a-multi-center-cross-sectional-study
#15
Gabriel J Estévez-Guerra, Emilio Fariña-López, Eduardo Núñez-González, Manuel Gandoy-Crego, Fernando Calvo-Francés, Elizabeth A Capezuti
BACKGROUND: Physical restraint is a procedure used frequently in long-term care. It is a controversial practice because its use is associated with numerous complications and also affects freedom and individual autonomy. The objective of this study was to examine the use of physical restraint of long-term care residents with the ability to move voluntarily. METHODS: We conducted a cross-sectional observational and correlational multi-center study. Nine centers agreed to participate...
January 21, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28109247/effectiveness-and-cost-effectiveness-of-a-guided-internet-and-mobile-based-intervention-for-the-indicated-prevention-of-major-depression-in-patients-with-chronic-back-pain-study-protocol-of-the-prod-bp-multicenter-pragmatic-rct
#16
L Sander, S Paganini, J Lin, S Schlicker, D D Ebert, C Buntrock, H Baumeister
BACKGROUND: Reducing the disease burden of major depressive disorder (MDD) is of major public health relevance. The prevention of depression is regarded as one possible approach to reach this goal. People with multiple risk factors for MDD such as chronic back pain and subthreshold depressive symptoms may benefit most from preventive measures. The Internet as intervention setting allows for scaling up preventive interventions on a public mental health level. METHODS: This study is a multicenter pragmatic randomized controlled trial (RCT) of parallel design aiming to investigate the (cost-) effectiveness of an Internet- and mobile-based intervention (IMI) for the prevention of depression in chronic back pain patients (PROD-BP) with subthreshold depressive symptoms...
January 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28109157/concerted-regulation-of-iswi-by-an-autoinhibitory-domain-and-the-h4-n-terminal-tail
#17
Johanna Ludwigsen, Sabrina Pfennig, Ashish K Singh, Christina Schindler, Nadine Harrer, Ignasi Forné, Martin Zacharias, Felix Mueller-Planitz
ISWI-family nucleosome remodeling enzymes need the histone H4 N-terminal tail to mobilize nucleosomes. Here we mapped the H4-tail binding pocket of ISWI. Surprisingly the binding site was adjacent to but not overlapping with the docking site of an auto-regulatory motif, AutoN, in the N-terminal region (NTR) of ISWI, indicating that AutoN does not act as a simple pseudosubstrate as suggested previously. Rather, AutoN cooperated with a hitherto uncharacterized motif, termed AcidicN, to confer H4-tail sensitivity and discriminate between DNA and nucleosomes...
January 21, 2017: ELife
https://www.readbyqxmd.com/read/28109076/microrna-409-3p-represses-glioma-cell-invasion-and-proliferation-by-targeting-high-mobility-group-nucleosome-binding-domain-5
#18
Yidong Cao, Liang Zhang, Minghao Wei, Xue Jiang, Dong Jia
Emerging evidence has suggested that aberrantly expressed microRNAs (miRNAs) are associated with glioma development andprogression. The aberrant expression of miR-409-3p has been reported in several human cancers. However, little is known about the function of miR-409-3p in gliomas. The aim of this study was to investigate the specific role and molecular mechanism of miR-409-3p in gliomas. In the present study, we found that miR-409-3p was downregulated in glioma tissue and cell lines. Overexpression of miR-409-3p inhibited glioma cell invasion and proliferation, whereas suppression of miR-409-3p promoted glioma cell invasion and proliferation...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109074/determination-of-four-nadolol-stereoisomers-in-capsules-by-high-performance-liquid-chromatography-and-circular-dichroism
#19
Grazielle Prado Alexandre, Márcio Nardelli Wandermuren, Adriano Peron, Vanessa Franco Tavares, Denis Alexandre Ramalho Padeiro, Kelly Alessandra Sakiara, María Segunda Aurora-Prado, Anil Kumar Singh, Erika Rosa Maria Kedor-Hackmann, Maria Inês Rocha Miritello Santoro
Nadolol is a blocking agent with activity in β-adrenergic receptors. The objective of this research was to develop andvalidate an HPLC and circular dichroism method for the quantification of four nadolol stereoisomers in capsules. The HPLC method was validated using a Chiralcel OD column (250 × 4,6 mm, 10 μm). The mobile phase consisted of hexane-ethanol-diethylamine-acetic acid(86 + 14 + 0.3 + 0.3, v/v/v/v), with a flow rate of 0.7 mL/min and temperature of 25 ± 1°C and UV detection carried out at 220 nm...
January 21, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28108937/glycyrrhizin-ameliorates-experimental-colitis-through-attenuating-interleukin-17-producing-t-cell-responses-via-regulating-antigen-presenting-cells
#20
Xiangyu Chen, Dai Fang, Lingyun Li, Liyong Chen, Qirui Li, Feili Gong, Min Fang
Glycyrrhizin, a component of Chinese medicine licorice root, has the ability to inhibit the functions of high-mobility group box 1 (HMGB1). While glycyrrhizin is known to have anti-inflammatory activities, the underlying mechanisms by which glycyrrhizin inhibits inflammation during the development of trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis are not well understood. This study systemically examined the regulatory effects of glycyrrhizin on inflammatory response in TNBS-induced murine colitis and explored the potential mechanisms involved in this process...
January 21, 2017: Immunologic Research
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