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https://www.readbyqxmd.com/read/29793165/inhibition-of-acetaminophen-induced-hepatotoxicity-in-mice-by-exogenous-thymosin%C3%AE-4-treatment
#1
Lei Wang, Xiankui Li, Cai Chen
OBJECTIVE: To study the effects of exogenous thymosinβ4 (Tβ4) treatment in acetaminophen (APAP)-induced hepatotoxicity. METHODS: Liver injury was induced in mice by a single intraperitoneal injection of APAP (500 mg/kg). Exogenous Tβ4 was intraperitoneally administrated at 0 h, 2 h and 4 h after APAP injection. Chloroquine (CQ) (60 mg/kg) was intraperitoneally injected 2 h before APAP administration to inhibit autophagy. Six hours after APAP injection liver injury was evaluated by histological examinations, biochemical measurements and enzyme linked immunosorbent assay (ELISAs)...
May 21, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29793126/effect-of-manual-therapy-versus-proprioceptive-neuromuscular-facilitation-in-dynamic-balance-mobility-and-flexibility-in-field-hockey-players-a-randomized-controlled-trial
#2
Gemma V Espí-López, Susana López-Martínez, Marta Inglés, Pilar Serra-Añó, Marta Aguilar-Rodríguez
OBJECTIVES: To compare the effectiveness of a specific Manual Therapy (MT) protocol applied to field hockey players (FHP), versus a Proprioceptive Neuromuscular Facilitation (PNF) protocol, in the improvement of dynamic balance, active range of movement and lumbar flexibility one-week and four-weeks after the treatment. DESIGN: Randomized controlled trial. Participants were assigned to 2 groups: MT and PNF. 30 min' sessions were performed once a week for three weeks...
April 22, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29793123/the-beighton-score-as-a-predictor-of-brighton-criteria-in-sport-and-dance
#3
Ross Armstrong, Dr Matt Greig
OBJECTIVES: To determine the efficacy of using the Beighton joint hypermobility score as a predictor of Brighton criteria components, considering the influence of gender and sports participation. DESIGN: Cross sectional study design. SETTING: A University. PARTICIPANTS: Sixty-five female rugby players, 38 male rugby players, 61 netball players, 42 female dancers, 40 male controls and 40 female controls. MAIN OUTCOME MEASURES: The Beighton score was assessed using the Beighton and Horan Joint Mobility Index...
April 20, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29793122/intra-and-interrater-reliability-of-the-lumbar-locked-thoracic-rotation-test-in-competitive-swimmers-ages-10-through-18-years
#4
Stef Feijen, Kevin Kuppens, Angela Tate, Isabel Baert, Thomas Struyf, Filip Struyf
OBJECTIVES: Measuring thoracic spine mobility can be of interest to competitive swimmers as it has been associated with shoulder girdle function and scapular position in subjects with and without shoulder pain. At present, no reliability data of thoracic spine mobility measurements are available in the swimming population. This study aims to evaluate the within-session intra- and interrater reliability of the "lumbar-locked rotation test" for thoracic spine rotation in competitive swimmers aged 10 to 18 years...
April 17, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29793082/atmospheric-impacts-of-a-natural-gas-development-within-the-urban-context-of-morgantown-west-virginia
#5
Philip J Williams, Matthew Reeder, Natalie J Pekney, David Risk, John Osborne, Michael McCawley
The Marcellus Shale Energy and Environment Laboratory (MSEEL) in West Virginia provides a unique opportunity in the field of unconventional energy research. By studying near-surface atmospheric chemistry over several phases of a hydraulic fracturing event, the project will help evaluate the impact of current practices, as well as new techniques and mitigation technologies. A total of 10 mobile surveys covering a distance of approximately 1500 km were conducted through Morgantown. Our surveying technique involved using a vehicle-mounted Los Gatos Research gas analyzer to provide geo-located measurements of methane (CH4 ) and carbon dioxide (CO2 )...
May 21, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29792940/a-randomized-control-trial-to-determine-the-effectiveness-and-physiological-effects-of-spinal-manipulation-and-spinal-mobilization-compared-to-each-other-and-a-sham-condition-in-patients-with-chronic-low-back-pain-study-protocol-for-the-relief-study
#6
Brian C Clark, David W Russ, Masato Nakazawa, Christopher R France, Stevan Walkowski, Timothy D Law, Megan Applegate, Niladri Mahato, Samuel Lietkam, James Odenthal, Daniel Corcos, Simeon Hain, Betty Sindelar, Robert J Ploutz-Snyder, James S Thomas
BACKGROUND: Low back pain (LBP) is one of the most common reasons for seeking medical care. Manipulative therapies are a common treatment for LBP. Few studies have compared the effectiveness of different types of manipulative therapies. Moreover, the physiologic mechanisms underlying these treatments are not fully understood. Herein, we present the study protocol for The Researching the Effectiveness of Lumbar Interventions for Enhancing Function Study (The RELIEF Study). METHODS AND STUDY DESIGN: The RELIEF Study is a Phase II RCT with a nested mechanistic design...
May 21, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29792921/characterization-of-solution-stress-degradation-products-of-aliskiren-and-prediction-of-their-physicochemical-and-admet-properties
#7
Bhoopendra Singh Kushwah, Jugal Gupta, Dilip Kumar Singh, Moolchand Kurmi, Archana Sahu, Saranjit Singh
Forced degradation studies on aliskiren were carried out according to ICH and WHO guidelines. Six degradation products were formed in total in the solution state. Their separation among themselves and from the drug was successfully achieved on a C-18 column utilizing acetonitrile and phosphate buffer (pH 3.0) in the mobile phase, which was run in a gradient mode. To characterize them, a complete mass fragmentation pathway of the drug was first established with the help of MS/TOF and MSn data. This was followed by LC-MS/TOF studies on the degradation products...
May 21, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29792893/tox-expression-decreases-with-progression-of-colorectal-cancers-and-is-associated-with-cd4-t-cell-density-and-fusobacterium-nucleatum-infection
#8
Ting Chen, Qing Li, Xiaoyan Zhang, Ran Long, Yaxin Wu, Jiao Wu, Xiangsheng Fu
Fusobacterium nucleatum (F. nucleatum) in the tumor microenvironment plays an important role in the development of colorectal cancer (CRC). The underlying mechanism of action, however, remains to be elucidated. We evaluated the relation of F. nucleatum amount to thymocyte selection-associated high-mobility group box (TOX) protein expression and CD4+ T cell density in 138 human colorectal tissues. TOX expression and CD4+ T cell density in F. nucleatum negative tissues were significantly higher compared to those in F...
May 21, 2018: Human Pathology
https://www.readbyqxmd.com/read/29792807/micelles-protect-intact-metallo-supramolecular-block-copolymer-complexes-from-solution-to-gas-phase-during-electrospray-ionization
#9
Kai Hung Huang, Tsung-Han Tu, Shi-Cheng Wang, Yi-Tsu Chan, Cheng-Chih Hsu
Supramolecular diblock copolymers using metal-ligand coordination can be synthesized under ambient conditions by delicate design of the end groups of the homopolymer chains. However, mass spectrometric analysis of such metallo-supramolecular copolymers is challenging. One of the reasons is the nonpolarity of the polymer chains, making it hard to disperse the complexes in electrospray ionization (ESI)-friendly environments. The other difficulty is the noncovalent nature of such copolymers, which is easily disrupted during the ionization...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792687/co-mobility-of-gabarap-and-phosphatidylinositol-4-kinase-2a-on-cytoplasmic-vesicles
#10
Yan Chen, Hui-Qiao Sun, John P Eichorst, Joseph P Albanesi, Helen Yin, Joachim D Mueller
We previously reported that recruitment of the Type IIA phosphatidylinositol 4-kinase (PI4K2A) to autophagosomes by GABARAP, a member of the Atg8 family of autophagy-related proteins, is important for autophagosome-lysosome fusion. Because both PI4K2A and GABARAP have also been implicated in the intracellular trafficking of plasma membrane receptors in the secretory/endocytic pathway, we characterized their interaction in cells under non-autophagic conditions. Fluorescence fluctuation spectroscopy measurements revealed that GABARAP exists predominantly as a cytosolic monomer in live cells, but is recruited to small cytoplasmic vesicles upon overexpression of PI4K2A...
May 24, 2018: Biochemistry
https://www.readbyqxmd.com/read/29792677/ultra-low-power-smart-electronic-nose-system-based-on-three-dimensional-tin-oxide-nanotube-arrays
#11
Jiaqi Chen, Zhuo Chen, Farid Boussaid, Daquan Zhang, Xiaofang Pan, Huijuan Zhao, Amine Bermak, Chi-Ying Tsui, Xinran Wang, Zhiyong Fan
In this work, we present a high performance smart electronic nose (E-nose) system consisting of multiplexed tin dioxide (SnO2) nanotube sensor array, read-out circuit, wireless data transmission unit, mobile phone receiver and data processing application (App). Using the proposed nanotube sensor device structure in conjunction with multiple electrode materials, high sensitivity gas detection and discrimination have been achieved at room temperature, enabling a 1,000 times reduction of sensor's power consumption as compared to a conventional device using thin film SnO2...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29792575/-seating-and-wheeled-mobility-a-clinical-resource-guide-book-review
#12
Tamara Kittelson-Aldred
No abstract text is available yet for this article.
May 24, 2018: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/29792574/evaluation-of-a-mobile-application-for-pelvic-floor-exercises
#13
Michelle N Han, Tamara Grisales, Aparna Sridhar
BACKGROUND: Pelvic floor exercises are effective in improving muscle strength and urinary incontinence symptoms. Increasingly popular mobile applications can be effective in teaching patients these exercises. INTRODUCTION: A mobile application, Bwom© , aims to educate women about pelvic floor exercises with individually tailored plans relevant to the user's risk factors. The objective of this study is to assess the understandability and actionability of Bwom. MATERIALS AND METHODS: This is a cross-sectional survey of patients and providers at an academic medical center...
May 24, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29792531/the-expression-of-lysophosphatidic-acid-receptor-5-is-necessary-for-the-regulation-of-intestinal-na-h-exchanger-3-by-lysophosphatidic-acid-in-vivo
#14
Kayte A Jenkin, Peijian He, C Chris Yun
Lysophosphatidic acid (LPA) is a bioactive lipid molecule, which regulates a broad range of pathophysiological processes. Recent studies have demonstrated that LPA modulates electrolyte flux in the intestine and its potential as an anti-diarrheal agent has been suggested. Of six LPA receptors, LPA5 is highly expressed in the intestine. Recent studies by our group have demonstrated activation of Na+ /H+ exchanger 3 (NHE3) by LPA5 . However, much of what has been elucidated was achieved using colonic cell lines that were transfected to express LPA5 ...
May 24, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29792417/directional-passive-transport-of-micro-droplets-in-oil-infused-diverging-channels-for-effective-condensate-removal
#15
Hongxia Li, Ablimit Aili, Mohamed H Alhosani, Qiaoyu Ge, TieJun Zhang
Condensation widely exists in nature and industry, and its performance heavily relies on the efficiency of condensate removal. Recent advances in micro/nano-scale surface engineering enable condensing droplet removal from solid surfaces without extra energy cost, but it is still challenging to achieve passive transport of micro-droplets over long distance along horizontal surfaces. The mobility of these condensate droplets can be enhanced by lubricant oil infusion on flat surfaces and frequent coalescence, which lead to fast growth but random motion of droplets...
May 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29792331/predictable-particle-engineering-programming-the-energy-level-carrier-generation-and-conductivity-of-core-shell-particles
#16
Conghui Yuan, Tong Wu, Jie Mao, Ting Chen, Yuntong Li, Min Li, Yiting Xu, Birong Zeng, Weiang Luo, Lingke Yu, Gaofeng Zheng, Lizong Dai
Core-shell structures are of particular interest in the development of advanced composite materials as they can efficiently bring different components together at nanoscale. The advantage of this structure greatly relies on the crucial design of both core and shell, thus achieving an inter-component synergistic effect. In this report, we show that decorating semiconductor nanocrystals with a boronate polymer shell can easily achieve programmable core-shell interactions. Taking ZnO and anatase TiO2 nanocrystals as inner core examples, the effective core-shell interactions can narrow the band gap of semiconductor nanocrystals, change the HOMO and LUMO levels of boronate polymer shell and significantly improve the carrier density of core-shell particles...
May 24, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29792327/multifunctional-binary-monolayers-gexpy-tunable-bandgap-ferromagnetism-and-photocatalyst-for-water-splitting
#17
Pengfei Li, Wei Zhang, Dongdong Li, Changhao Liang, Xiao Cheng Zeng
The most stable structures of two-dimensional (2D) GexPy and GexAsy monolayers with different stoichiometry (e.g., GeP, GeP2, GeP3) are explored systematically through the combination of the particle-swarm optimization (PSO) technique and density functional theory optimization. For GeP3, we show that the newly predicted most stable C2/m structure is 0.16 eV/atom lower in energy than the state-of-the-art P-3m1 structure reported previously (Nano Lett.2017, 17, 1833). The computed electronic band structures suggest that all the stable and metastable monolayers of GexPy are semiconductors with highly tunable bandgaps under the biaxial strain, allowing strain engineering of their bandgaps within nearly the whole visible-light range...
May 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29792326/common-principles-of-molecular-electronics-and-nanoscale-electrochemistry
#18
Paulo Roberto Bueno
The merging of nanoscale electronics and electrochemistry can potentially modernize the way electronic devices are currently engineered or constructed. It is well known that the greatest challenges will involve not only miniaturizing and improving the performance of mobile devices, but also manufacturing reliable electrical vehicles, and engineering more efficient solar panels and energy storage systems. These are just a few examples of how technological innovation is dependent on both electrochemical and electronic elements...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792292/identifying-medication-management-smartphone-app-features-suitable-for-young-adults-with-developmental-disabilities-delphi-consensus-study
#19
Teresa M Salgado, Alexa Fedrigon, Donna Riccio Omichinski, Michelle A Meade, Karen B Farris
BACKGROUND: Smartphone apps can be a tool to facilitate independent medication management among persons with developmental disabilities. At present, multiple medication management apps exist in the market, but only 1 has been specifically designed for persons with developmental disabilities. Before initiating further app development targeting this population, input from stakeholders including persons with developmental disabilities, caregivers, and professionals regarding the most preferred features should be obtained...
May 23, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29792290/the-use-of-mobile-health-applications-to-improve-patient-experience-cross-sectional-study-in-chinese-public-hospitals
#20
Chuntao Lu, Yinhuan Hu, Jinzhu Xie, Qiang Fu, Isabella Leigh, Samuel Governor, Guanping Wang
BACKGROUND: The proliferation of mobile health apps has greatly changed the way society accesses the health care industry. However, despite the widespread use of mobile health apps by patients in China, there has been little research that evaluates the effect of mobile health apps on patient experience during hospital visits. OBJECTIVE: The purpose of our study was to examine whether the use of mobile health apps improves patient experience and to find out the difference in patient experience between users and nonusers and the characteristics associated with the users of these apps...
May 23, 2018: JMIR MHealth and UHealth
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