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https://www.readbyqxmd.com/read/27913294/sleep-mediated-memory-consolidation-depends-on-the-level-of-integration-at-encoding
#1
Lea Himmer, Elias Müller, Steffen Gais, Monika Schönauer
There is robust evidence that sleep facilitates declarative memory consolidation. Integration of newly acquired memories into existing neocortical knowledge networks has been proposed to underlie this effect. Here, we test whether sleep affects memory retention for word-picture associations differently when it was learned explicitly or using a fast mapping strategy. Fast mapping is an incidental form of learning that references new information to existing knowledge and possibly allows neocortical integration already during encoding...
November 29, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27913062/physiotherapists-and-general-practitioners-attitudes-towards-physio-direct-phone-based-musculoskeletal-physiotherapy-services-a-national-survey
#2
Nicholas Harland, Brian Blacklidge
OBJECTIVES: Physiotherapy phone based, "Physio Direct" (PD) musculoskeletal triage and treat services are a relatively new phenomena. This study explored Physiotherapist and GP attitudes towards PD services. DESIGN: Online national survey via cascade e-mail initiated by study leads. PARTICIPANTS: 488 Physiotherapists and 68 GPs completed the survey. OUTCOME MEASURES: The survey asked three negatively worded and three positively worded Likert scale questions regarding PD services...
September 17, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27913029/pharmacovigilance-and-biomedical-informatics-a-model-for-future-development
#3
Paul Beninger, Michael A Ibara
PURPOSE: The discipline of pharmacovigilance is rooted in the aftermath of the thalidomide tragedy of 1961. It has evolved as a result of collaborative efforts by many individuals and organizations, including physicians, patients, Health Authorities, universities, industry, the World Health Organization, the Council for International Organizations of Medical Sciences, and the International Conference on Harmonisation. Biomedical informatics is rooted in technologically based methodologies and has evolved at the speed of computer technology...
November 29, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27912894/self-generation-and-positivity-effects-following-transcranial-random-noise-stimulation-in-medial-prefrontal-cortex-a-reality-monitoring-task-in-older-adults
#4
Nicola Mammarella, Alberto Di Domenico, Rocco Palumbo, Beth Fairfield
Activation of medial Prefrontal Cortex (mPFC) has been typically found during reality monitoring tasks (i.e., distinguishing between internal self-generated vs external information). No study, however, has yet investigated whether transcranial Random Noise Stimulation (tRNS) over the mPFC leads to a reduction in reality-monitoring misattributions in aging. In particular, stimulating mPFC should increase the number of cognitive operations engaged while encoding and this distinctive information may help older adults to discriminate between internal and external sources better...
November 15, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27912107/limits-to-tdcs-effects-in-language-failures-to-modulate-word-production-in-healthy-participants-with-frontal-or-temporal-tdcs
#5
Samuel J Westwood, Andrew Olson, R Chris Miall, Raffaele Nappo, Cristina Romani
Transcranial direct current stimulation (tDCS) is a method of non-invasive brain stimulation widely used to modulate cognitive functions. Recent studies, however, suggests that effects are unreliable, small and often non-significant at least when stimulation is applied in a single session to healthy individuals. We examined the effects of frontal and temporal lobe anodal tDCS on naming and reading tasks and considered possible interactions with linguistic activation and selection mechanisms as well as possible interactions with item difficulty and participant individual variability...
November 3, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27911586/mirna-181a-b-regulates-phenotypes-of-vessel-smooth-muscle-cells-through-serum-response-factor
#6
Xiaoxing Wei, Xue Hou, Jianhua Li, Yongnian Liu
The phenotypic modulation of vessel smooth muscle cells (VSMCs) plays a crucial role in the physiological and pathological conditions of vasculature in response to local environmental changes. The phenotypic transition of VSMCs is largely modulated by the serum response factor (SRF). MiR-181a and miR-181b are members of the well-studied miR-181 family and both have complementary sequence in the 3' untranslated region (UTR) of SRF gene. In this article, evidence insinuates that miR-181a/b was involved in VSMCs differentiation through upregulating synthetic marker genes and downregulating contractile ones, respectively...
December 2, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27910735/birth-of-the-cool-a-two-centuries-decline-in-emotional-expression-in-anglophone-fiction
#7
Olivier Morin, Alberto Acerbi
The presence of emotional words and content in stories has been shown to enhance a story's memorability, and its cultural success. Yet, recent cultural trends run in the opposite direction. Using the Google Books corpus, coupled with two metadata-rich corpora of Anglophone fiction books, we show a decrease in emotionality in English-speaking literature starting plausibly in the nineteenth century. We show that this decrease cannot be explained by changes unrelated to emotionality (such as demographic dynamics concerning age or gender balance, changes in vocabulary richness, or changes in the prevalence of literary genres), and that, in our three corpora, the decrease is driven almost entirely by a decline in the proportion of positive emotion-related words, while the frequency of negative emotion-related words shows little if any decline...
December 2, 2016: Cognition & Emotion
https://www.readbyqxmd.com/read/27909981/the-effect-of-working-memory-load-on-the-snarc-effect-maybe-tasks-have-a-word-to-say
#8
Zhijun Deng, Yinghe Chen, Xiaoshuang Zhu, Yanjun Li
We investigated the effect of working memory load on the SNARC (spatial-numerical association of response codes) effect under different number judgment tasks (parity judgment and magnitude comparison), using a novel dual task. Instead of exerting load over the whole block of number judgment trials, in this dual task, number judgment trials were inserted into each interstimulus interval of an n-back task, which served as the working memory load. We varied both load type (verbal and spatial) and amount (1-load, 2-load, and 3-load)...
December 1, 2016: Memory & Cognition
https://www.readbyqxmd.com/read/27909011/age-dependent-effects-of-catechol-o-methyltransferase-comt-gene-val158met-polymorphism-on-language-function-in-developing-children
#9
Lisa Sugiura, Tomoko Toyota, Hiroko Matsuba-Kurita, Yoshimi Iwayama, Reiko Mazuka, Takeo Yoshikawa, Hiroko Hagiwara
The genetic basis controlling language development remains elusive. Previous studies of the catechol-O-methyltransferase (COMT) Val(158)Met genotype and cognition have focused on prefrontally guided executive functions involving dopamine. However, COMT may further influence posterior cortical regions implicated in language perception. We investigated whether COMT influences language ability and cortical language processing involving the posterior language regions in 246 children aged 6-10 years. We assessed language ability using a language test and cortical responses recorded during language processing using a word repetition task and functional near-infrared spectroscopy...
November 30, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27908038/phonetic-imitation-of-coarticulatory-vowel-nasalization
#10
Georgia Zellou, Rebecca Scarborough, Kuniko Nielsen
This study investigates the spontaneous phonetic imitation of coarticulatory vowel nasalization. Speakers produced monosyllabic words with a vowel-nasal sequence either from dense or sparse phonological neighborhoods in shadowing and word-naming tasks. During shadowing, they were exposed to target words that were modified to have either an artificially increased or decreased degree of coarticulatory vowel nasality. Increased nasality, which is communicatively more facilitative in that it provides robust predictive information about the upcoming nasal segment, was imitated more strongly during shadowing than decreased nasality...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27906946/long-term-follow-up-results-of-percutaneous-endoscopic-lumbar-discectomy
#11
Sang Soo Eun, Sang-Ho Lee, Luigi Andrew Sabal
BACKGROUND: Open lumbar microdiscectomy (OLM) has been considered the gold standard in the management of lumbar disc herniation (LDH) for its favorable outcomes in long-term follow-up. Nowadays, percutaneous endoscopic lumbar discectomy (PELD) is gaining recognition. However, greatest limitation of studies of PELD is the lack of long-term follow-up outcomes. OBJECTIVE: To investigate the long-term outcomes of PELD in terms of clinical and radiographic findings and revision surgery rate...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27905866/morphological-structure-influences-the-initial-landing-position-in-words-during-reading-finnish
#12
Jukka Hyönä, Ming Yan, Seppo Vainio
The preferred viewing location in words (Rayner, 1979) during reading is near the word center. Parafoveal word length information is utilized to guide the eyes toward it. A recent study of Yan et al. (2014) demonstrated that the word's morphological structure may also be used in saccadic targeting. The study was conducted in a morphologically rich language, Uighur. The present study aimed at replicating their main findings in another morphologically rich language, Finnish. Similarly to Yan et al., it was found that the initial fixation landed closer to the word beginning for morphologically complex than monomorphemic words...
December 1, 2016: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/27905253/effects-of-context-expectation-on-prospective-memory-performance-among-older-and-younger-adults
#13
Terrence K Kominsky, Celinda Reese-Melancon
This experiment examined the impact of context expectation on prospective memory (PM) performance among older and younger adults. Participants responded to PM target words embedded in an ongoing lexical decision task (LDT). Older and younger adults performed similarly on the PM task. Regardless of age, PM was significantly better for participants in the correct context expectation condition and significantly worse in the incorrect context expectation condition relative to participants who held no expectations about the context in which targets would appear...
January 2017: Memory
https://www.readbyqxmd.com/read/27904567/dual-malignancy-in-adolescence-a-rare-case-report-of-metachronous-papillary-carcinoma-of-thyroid-following-dysgerminoma-of-ovary
#14
Suvadip Chakrabarti, Sanjay M Desai, Dharmendra Y Mehta, Shreyas Somanath
Dual malignancy is rare in adolescents. Dual malignancy with the second malignancy of thyroid is rare. No association has been reported between dysgerminoma of ovary and carcinoma thyroid in medical literature. Despite a thorough PubMed search (key words - Papillary carcinoma of thyroid, metachronous, dysgerminoma ovary), we were unable to find a previous reported case of metachronous papillary carcinoma of thyroid (PTC) following dysgerminoma of the ovary. After surgery, the patient is being regularly followed up for recurrence/development of new primary...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27904558/relationships-of-mmp-9-and-timp-1-proteins-with-chronic-obstructive-pulmonary-disease-risk-a-systematic-review-and-meta-analysis
#15
REVIEW
Yangxue Li, Yang Lu, Zhuo Zhao, Junnan Wang, Jianxin Li, Weiming Wang, Shumei Li, Lei Song
BACKGROUND: We performed this meta-analysis in order to collect all the relevant studies to clarify the correlations of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: After a literature search in electronic databases, pertinent case-control studies investigating the correlations of MMP-9 and TIMP-1 protein expressions within a COPD setting were enrolled based on our strict inclusion and exclusion criteria...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903959/genome-wide-haplotype-association-study-identify-the-fgfr2-gene-as-a-risk-gene-for-acute-myeloid-leukemia
#16
Hongchao Lv, Mingming Zhang, Zhenwei Shang, Jin Li, Shanshan Zhang, Duan Lian, Ruijie Zhang
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, and generally considered to be caused by environment and genetic factors. In this study, we combined a genome-wide haplotype association study (GWHAS) and gene prioritization strategy to mine AML-related genetic affect factors and understand its pathogenesis. A total of 175 AML patients were downloaded from the public GEO database (GSE32462) and 218 matched Caucasian controls were from the HapMap Project. We first identified the linkage disequilibrium (LD) blocks and performed a GWHAS to scan AML-related haplotypes...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27903727/predicting-when-in-discourse-engages-the-human-dorsal-auditory-stream-an-fmri-study-using-naturalistic-stories
#17
Katerina Danae Kandylaki, Arne Nagels, Sarah Tune, Tilo Kircher, Richard Wiese, Matthias Schlesewsky, Ina Bornkessel-Schlesewsky
: The hierarchical organization of human cortical circuits integrates information across different timescales via temporal receptive windows, which increase in length from lower to higher levels of the cortical hierarchy (Hasson et al., 2015). A recent neurobiological model of higher-order language processing (Bornkessel-Schlesewsky et al., 2015) posits that temporal receptive windows in the dorsal auditory stream provide the basis for a hierarchically organized predictive coding architecture (Friston and Kiebel, 2009)...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903704/semantic-congruence-accelerates-the-onset-of-the-neural-signals-of-successful-memory-encoding
#18
P A Packard, A Rodríguez-Fornells, N Bunzeck, B Nicolás, R de Diego-Balaguer, L Fuentemilla
: As the stream of experience unfolds, our memory system rapidly transforms current inputs into long-lasting meaningful memories. A putative neural mechanism that strongly influences how input elements are transformed into meaningful memory codes relies on the ability to integrate them with existing structures of knowledge or schemas. However, it is not yet clear whether schema-related integration neural mechanisms occur during online encoding. In the current investigation, we examined the encoding-dependent nature of this phenomenon in humans...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903489/finding-important-terms-for-patients-in-their-electronic-health-records-a-learning-to-rank-approach-using-expert-annotations
#19
Jinying Chen, Jiaping Zheng, Hong Yu
BACKGROUND: Many health organizations allow patients to access their own electronic health record (EHR) notes through online patient portals as a way to enhance patient-centered care. However, EHR notes are typically long and contain abundant medical jargon that can be difficult for patients to understand. In addition, many medical terms in patients' notes are not directly related to their health care needs. One way to help patients better comprehend their own notes is to reduce information overload and help them focus on medical terms that matter most to them...
November 30, 2016: JMIR Medical Informatics
https://www.readbyqxmd.com/read/27900869/-evaluation-of-five-years-of-treatment-of-erdheim-chester-disease-with-anakinra-case-report-and-overview-of-literature
#20
Zdeněk Adam, Hana Petrášová, Zdeněk Řehák, Renata Koukalová, Marta Krejčí, Luděk Pour, Eva Vetešníková, Aleš Čermák, Sabina Ševčíková, Petr Szturz, Zdeněk Král, Jiří Mayer
: Erdheim-Chester disease is a histiocytic neoplasm of diseases from the group of non-Langerhans-cell histiocytoses, formed by infiltrates of foamy histiocytes. These pathological histiocytes produce pro-inflammatory cytokines. Therefore Erdheim-Chester disease is called inflammatory histiocytary neoplasm. The disease is accompanied by clinical symptoms of systemic inflammatory response, i.e. B symptoms. Imaging examinations detect typical osteosclerotic changes affecting diaphyses and metaphyses of the lower long bones and fibrotic changes which affect the aorta wall and the vessels leading from it...
2016: Vnitr̆ní Lékar̆ství
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