Lionel Perrier, Frédéric Balusson, Magali Morelle, Joël Castelli, Juliette Thariat, Karen Benezery, Ali Hasbini, Bernard Gery, Antoine Berger, Xavier Liem, Sébastien Guihard, Sophie Chapet, Sébastien Thureau, Pierre Auberdiac, Pascal Pommier, Amandine Ruffier, Anne Devillers, Emmanuel Oger, Boris Campillo-Gimenez, Renaud de Crevoisier
BACKGROUND AND PURPOSE: We performed a cost-effectiveness analysis (CEA) comparing an adaptive radiotherapy (ART) strategy, based on weekly replanning, aiming to correct the parotid gland overdose during treatment and expecting therefore to decrease xerostomia, when compared to a standard IMRT. MATERIALS AND METHODS: We conducted the ARTIX trial, a randomized, parallel-group, multicentric study comparing a systematic weekly replanning ART to a standard IMRT. The primary endpoint was the frequency of xerostomia at 12 months, measured by stimulating salivary flow with paraffin...
February 3, 2024: Radiotherapy and Oncology