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https://www.readbyqxmd.com/read/29209316/complement-protein-c1q-binds-to-hyaluronic-acid-in-the-malignant-pleural-mesothelioma-microenvironment-and-promotes-tumor-growth
#1
Chiara Agostinis, Romana Vidergar, Beatrice Belmonte, Alessandro Mangogna, Leonardo Amadio, Pietro Geri, Violetta Borelli, Fabrizio Zanconati, Francesco Tedesco, Marco Confalonieri, Claudio Tripodo, Uday Kishore, Roberta Bulla
C1q is the first recognition subcomponent of the complement classical pathway, which acts toward the clearance of pathogens and apoptotic cells. C1q is also known to modulate a range of functions of immune and non-immune cells, and has been shown to be involved in placental development and sensorial synaptic pruning. We have recently shown that C1q can promote tumor by encouraging their adhesion, migration, and proliferation in addition to angiogenesis and metastasis. In this study, we have examined the role of human C1q in the microenvironment of malignant pleural mesothelioma (MPM), a rare form of cancer commonly associated with exposure to asbestos...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29207017/a-common-african-variant-of-human-connexin%C3%A2-37-is-associated-with-caucasian-primary-ovarian-insufficiency-and-has-a-deleterious-effect-in%C3%A2-vitro
#2
Anne Bachelot, Jerome Gilleron, Geri Meduri, Mihelai Guberto, Jerome Dulon, Sylviane Boucherie, Philippe Touraine, Micheline Misrahi
Folliculogenesis requires communication between granulosa cells and oocytes, mediated by connexin-based gap junctions. Connexin 37 (Cx37)-deficient female mice are infertile. The present study assessed Cx37 deficiency in patients with primary ovarian insufficiency (POI). A candidate gene study was performed in patients and controls from the National Genotyping Center (Evry, France) including 58 Caucasian patients with idiopathic isolated POI and 142 Caucasian controls. Direct genomic sequencing of the coding regions of the GJA4 gene (encoding Cx37) was performed with the aim to identify a deleterious variant associated with POI and absent in ethnically matched controls...
November 16, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205733/borazine-cf3-adducts-for-rapid-room-temperature-and-broad-scope-trifluoromethylation
#3
Jacob Benjamin Geri, Michael McCreery Wade Wolfe, Nathaniel Kolnik Szymczak
We present a strategy to use a fluoroform-derived borazine CF3- transfer reagent to effect rapid nucleophilic reactions in the absence of exogenous activator additives within minutes at room temperature. Inorganic electrophiles spanning 7 groups of the periodic table can be trifluoromethylated in high yield, including transition metals used for catalytic trifluoromethylation. Organic electrophiles included arenes and heteroarenes, enabling C-H, C-X (F, Cl), and C-NO2 trifluoromethylation reactions. Mechanistic analysis supports a dissociative mechanism for CF3- transfer, and cation modification afforded a reagent with enhanced stability...
December 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29205280/maximizing-neotissue-growth-kinetics-in-a-perfusion-bioreactor-an-in-silico-strategy-using-model-reduction-and-bayesian-optimization
#4
Mohammad Mehrian, Yann Guyot, Ioannis Papantoniou, Simon Olofsson, Maarten Sonnaert, Ruth Misener, Liesbet Geris
In regenerative medicine, computer models describing bioreactor processes can assist in designing optimal process conditions leading to robust and economically viable products. In this study, we started from a (3D) mechanistic model describing the growth of neotissue, comprised of cells and extracellular matrix, in a perfusion bioreactor set-up influenced by the scaffold geometry, flow-induced shear stress and a number of metabolic factors. Subsequently, we applied model reduction by reformulating the problem from a set of partial differential equations into a set of ordinary differential equations...
December 4, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29189582/aerobic-fitness-in-top-class-soccer-referees
#5
Carlo Castagna, Mario Bizzini, Susana C Araújo Póvoas, Kai Schenk, Gery Büsser, Stefano DʼOttavio
Castagna, C, Bizzini, M, Araújo Póvoas, SC, Schenk, K, Büsser, G, and D'Ottavio, S. Aerobic fitness in top-class soccer referees. J Strength Cond Res XX(X): 000-000, 2017-The aim of this study was to examine the aerobic fitness status of top-class male soccer officials using a cross-sectional design and known population group constructs. Fifty-two field referees (FRs, age 38.4 ± 3.3 years; height 181 ± 5.6 cm; body mass 76.8 ± 6.8 kg; body mass index [BMI] 23.4 ± 1.7 kg·m; body fat 20.4 ± 3.6%; and international refereeing experience 5 ± 3...
November 16, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29183067/prescription-drug-monitoring-programs-and-opioid-death-rates-reply
#6
Anne Schuchat, Gery P Guy, Deborah Dowell
No abstract text is available yet for this article.
November 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29173739/a-two-week-psychosocial-intervention-reduces-future-aggression-and-incarceration-in-clinically-aggressive-juvenile-offenders
#7
Ashley D Kendall, Erin M Emerson, William E Hartmann, Richard E Zinbarg, Geri R Donenberg
OBJECTIVE: There is a largely unmet need for evidence-based interventions that reduce future aggression and incarceration in clinically aggressive juvenile offenders serving probation. We addressed this gap using a group randomized controlled trial. Offenders both with and without clinical aggression were included, enabling comparison of intervention effects. METHOD: Juveniles 13 to 17 years old (N = 310, mean = 16 years, 90% African-American, 66% male) on probation were assigned to a 2-week intervention targeting psychosocial factors implicated in risky behavior (e...
December 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29162559/enhancing-the-usability-of-an-optical-reader-system-to-support-point-of-care-rapid-diagnostic-testing-an-iterative-design-approach
#8
Jess Hohenstein, Dakota O'Dell, Elizabeth L Murnane, Zhengda Lu, David Erickson, Geri Gay
BACKGROUND: In today's health care environment, increasing costs and inadequate medical resources have created a worldwide need for more affordable diagnostic tools that are also portable, fast, and easy to use. To address this issue, numerous research and commercial efforts have focused on developing rapid diagnostic technologies; however, the efficacy of existing systems has been hindered by usability problems or high production costs, making them infeasible for deployment in at-home, point-of-care (POC), or resource-limited settings...
November 21, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/29155784/correlative-super-resolution-and-electron-microscopy-to-resolve-protein-localization-in-zebrafish-retina
#9
José M Mateos, Gery Barmettler, Jana Doehner, Irene Ojeda Naharros, Bruno Guhl, Stephan C F Neuhauss, Andres Kaech, Ruxandra Bachmann-Gagescu, Urs Ziegler
We present a method to investigate the subcellular protein localization in the larval zebrafish retina by combining super-resolution light microscopy and scanning electron microscopy. The sub-diffraction limit resolution capabilities of super-resolution light microscopes allow improving the accuracy of the correlated data. Briefly, 110 nanometer thick cryo-sections are transferred to a silicon wafer and, after immunofluorescence staining, are imaged by super-resolution light microscopy. Subsequently, the sections are preserved in methylcellulose and platinum shadowed prior to imaging in a scanning electron microscope (SEM)...
November 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29145609/the-differential-effects-of-hiv-and-hcv-on-bone-micro-architecture-and-fracture-risk
#10
Roger J Bedimo, Beverley Adams-Huet, John Poindexter, Geri Brown, Irfan Farukhi, Rosinda Castanon, Diana Turner, Teresa Moore, Pablo Tebas, Naim M Maalouf
Background: HIV/HCV co-infected subjects have a significantly greater osteoporotic fracture risk than HIV-infected, despite the fact that HIV/HCV co-infection has not been associated with lower bone mineral density (BMD) than HIV or HCV alone. We evaluated if changes in bone microarchitecture , measured by trabecular bone score (TBS) could explain these differences. Design: We performed a prospective, cross-sectional cohort study of virologically suppressed HIV, untreated HCV, HIV/HCV co-infected and non-infected controls...
November 14, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29132953/emergency-department-visits-involving-opioid-overdoses-u-s-2010-2014
#11
Gery P Guy, Emilia Pasalic, Kun Zhang
No abstract text is available yet for this article.
November 10, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29132797/cloaca-reconstruction-a-new-algorithm-which-considers-the-role-of-urethral-length-in-determining-surgical-planning
#12
Richard J Wood, Carlos A Reck-Burneo, Daniel Dajusta, Christina Ching, Rama Jayanthi, D Gregory Bates, Molly E Fuchs, Katherine McCracken, Geri Hewitt, Marc A Levitt
BACKGROUND: Cloacal malformations represent a uniquely complex challenge for surgeons. The surgical approach to date has been based on the common channel (CC) length with two patient groups considered: less than or greater than 3cm, which we believe is an oversimplification. We reviewed 19 patients, referred after surgery done elsewhere. Eight had postoperative urinary complications, 3 had constant urinary leakage and had been left after surgery with a urethra <1cm, .5 with an original 3 to 5cm common channel, who had undergone total urogenital mobilization (TUM), experienced peri-operative urethral loss needing a vesicostomy, and later, a Mitrofanoff...
October 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29123155/large-scale-in-vitro-production-refolding-and-dimerization-of-psbs-in-different-microenvironments
#13
Maithili Krishnan, Geri F Moolenaar, Karthick Babu Sai Sankar Gupta, Nora Goosen, Anjali Pandit
Plants adapt to fluctuating light conditions by a process called non-photochemical quenching (NPQ), where membrane protein PsbS plays a crucial role and transforms a change in the pH-gradient across the thylakoid membrane under excess light conditions into a photoprotective state, leading to de-excitation of antenna chlorophylls. The PsbS activation mechanism is elusive and has been proposed to involve a monomerization step and protonation of specific residues. To elucidate its function, it is essential to produce PsbS in large quantities, stabilize PsbS in a membrane-mimicking environment and analyze its pH-dependent conformational structure...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115211/measurement-of-gastrointestinal-hormones
#14
Nicolai J Wewer Albrechtsen
Towards the end of the 20th century, the number of subjects with diabetes and obesity rose exponentially. The discoveries of insulin- and appetite-modulating chemical signals, including glucagon-like peptide-1 (GLP-1), secreted from the gastrointestinal system, led to development of a new group of drugs which now are being used for glucose-lowering therapy and weight loss. Understanding of the physiology of gut derived signals and their pathophysiologi-cal importance requires accurate measurements of their circulat-ing levels...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29109286/circadian-clock-cryptochrome-proteins-regulate-autoimmunity
#15
Qi Cao, Xuan Zhao, Jingwen Bai, Sigal Gery, Haibo Sun, De-Chen Lin, Qi Chen, Zhengshan Chen, Lauren Mack, Henry Yang, Ruishu Deng, Xianping Shi, Ling-Wa Chong, Han Cho, Jianjun Xie, Quan-Zhen Li, Markus Müschen, Annette R Atkins, Christopher Liddle, Ruth T Yu, Serhan Alkan, Jonathan W Said, Ye Zheng, Michael Downes, Ronald M Evans, H Phillip Koeffler
The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [Cry double knockout (DKO)] develop an autoimmune phenotype including high serum IgG concentrations, serum antinuclear antibodies, and precipitation of IgG, IgM, and complement 3 in glomeruli and massive infiltration of leukocytes into the lungs and kidneys. Flow cytometry of lymphoid organs revealed decreased pre-B cell numbers and a higher percentage of mature recirculating B cells in the bone marrow, as well as increased numbers of B2 B cells in the peritoneal cavity of Cry DKO mice...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29106919/using-quality-improvement-methodology-to-improve-ovarian-salvage-for-benign-ovarian-masses
#16
Jennifer H Aldrink, Dani O Gonzalez, Stephen P Sales, Katherine J Deans, Gail E Besner, Geri D Hewitt
PURPOSE: Most ovarian masses in children are benign and potentially amenable to ovarian salvage surgery (OSS). Despite the common use of OSS among pediatric and adolescent gynecologists (PAG) in recognition of reproductive and hormonal health advantages, this technique is not commonly performed by pediatric surgeons. The aim of this quality improvement (QI) initiative was to improve our institutional rate of OSS for benign ovarian masses. METHODS: Baseline data were obtained retrospectively from surgical procedures performed for benign ovarian masses between January 2012 and February 2016...
October 10, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29095417/a-web-based-multimedia-program-before-colonoscopy-increased-knowledge-and-decreased-anxiety-sedation-requirement-and-procedure-time
#17
Siddhartha Parker, Jonathan Zipursky, Helen Ma, Geri-Lynn Baumblatt, Corey A Siegel
GOALS: Assess the impact of a web-based multimedia patient engagement program on patient anxiety, perception and knowledge about the colonoscopy in addition to procedure outcomes. BACKGROUND: The success of patients coming for a colonoscopy for colorectal cancer screening is dependent in part on patients' understanding of the preparation and of the procedure. Patients were randomized to use either our institution's standard preprocedure colonoscopy packet or a web-based multimedia patient engagement program (Emmi Solutions) before their scheduled procedure...
October 31, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29095203/acute-respiratory-distress-syndrome-cases-volume-and-icu-mortality-in-medical-patients
#18
Martin Dres, Peter C Austin, Tài Pham, Philippe Aegerter, Bertrand Guidet, Alexandre Demoule, Antoine Vieillard-Baron, Laurent Brochard, Guillaume Géri
OBJECTIVES: To determine whether ICUs caring for higher volumes of acute respiratory distress syndrome patients would be associated with lower ICU mortality. DESIGN: A 9-year multicenter retrospective cohort study of prospectively collected data. SETTING: French medical ICUs. PATIENTS: From 2004 to 2012, acute respiratory distress syndrome cases were identified from a coding system through a regional database (Collège des Utilisateurs de Données en Réanimation)...
October 31, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29088928/geri-bd-a-randomized-double-blind-controlled-trial-of-lithium-and-divalproex-in-the-treatment-of-mania-in-older-patients-with-bipolar-disorder
#19
RANDOMIZED CONTROLLED TRIAL
Robert C Young, Benoit H Mulsant, Martha Sajatovic, Ariel G Gildengers, Laszlo Gyulai, Rayan K Al Jurdi, John Beyer, Jovier Evans, Samprit Banerjee, Rebecca Greenberg, Patricia Marino, Mark E Kunik, Peijun Chen, Marna Barrett, Herbert C Schulberg, Martha L Bruce, Charles F Reynolds, George S Alexopoulos
OBJECTIVE: Clinicians treating older patients with bipolar disorder with mood stabilizers need evidence from age-specific randomized controlled trials. The authors describe findings from a first such study of late-life mania. METHOD: The authors compared the tolerability and efficacy of lithium carbonate and divalproex in 224 inpatients and outpatients age 60 or older with bipolar I disorder who presented with a manic, hypomanic, or mixed episode. Participants were randomly assigned, under double-blind conditions, to treatment with lithium (target serum concentration, 0...
November 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29079481/g-protein-g%C3%AE-13-functions-with-abl-kinase-to-regulate-actin-cytoskeletal-reorganization
#20
Limin Wang, Dawei Wang, Bowen Xing, Ying-Cai Tan, Jianyun Huang, Bingqian Liu, Viktoriya Syrovatkina, Cedric Espenel, Geri Kreitzer, Lin Guo, J Jillian Zhang, Xin-Yun Huang
Heterotrimeric G-proteins are essential cellular signal transducers. One of the G-proteins, Gα13, is critical for actin cytoskeletal reorganization, cell migration, cell proliferation, and apoptosis. Previously, we have shown that Gα13 is essential for both G-protein-coupled receptor and receptor tyrosine kinase-induced actin cytoskeletal reorganization such as dynamic dorsal ruffle turnover and cell migration. However, the mechanism by which Gα13 signals to actin cytoskeletal reorganization is not completely understood...
October 25, 2017: Journal of Molecular Biology
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