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https://www.readbyqxmd.com/read/28441162/managing-herpes-zoster-in-older-adults-prescribing-considerations
#1
Linda Beuscher, Geri Reeves, Debbie Harrell
NPs must be aware of special prescribing considerations for medication safety when managing the care of older adults with herpes zoster. Age-related physiologic changes of the body impact the pharmacokinetics and pharmacodynamics of antiviral and pain medications and can lead to potential adverse events.
April 24, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/28437826/normal-left-ventricular-size-in-premature-newborns-by-the-echocardiographic-bullet-method
#2
Kenneth Bayle, Geri Galotti, Jill Nielsen-Farrell, Jie Yang, James Cordry Nielsen, Laurie Panesar
No abstract text is available yet for this article.
April 24, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28437150/cost-of-cancer-related-neutropenia-or-fever-hospitalizations-united-states-2012
#3
Eric Tai, Gery P Guy, Angela Dunbar, Lisa C Richardson
PURPOSE: Neutropenia and subsequent infections are life-threatening treatment-related toxicities of chemotherapy. Among patients with cancer, hospitalizations related to neutropenic complications result in substantial medical costs, morbidity, and mortality. Previous estimates for the cost of cancer-related neutropenia hospitalizations are based on older and limited data. This study provides nationally representative estimates of the cost of cancer-related neutropenia hospitalizations...
April 24, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28432514/breast-cancer-treatment-costs-in-younger-privately-insured-women
#4
Benjamin T Allaire, Donatus U Ekwueme, Diana Poehler, Cheryll C Thomas, Gery P Guy, Sujha Subramanian, Justin G Trogdon
PURPOSE: Younger women (under age 45 years) diagnosed with breast cancer often face more aggressive tumors, higher treatment intensity, lower survival rates, and greater financial hardship. The purpose of this study was to estimate breast cancer costs by stage at diagnosis during the first 18 months of treatment for privately insured younger women. METHODS: We analyzed North Carolina cancer registry data linked to claims data from private insurers from 2003 to 2010...
April 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28431058/additional-electrodes-on-the-quartet%C3%A2-lv-lead-provide-more-programmable-pacing-options-than-bipolar-and-tripolar-equivalents
#5
David O'Donnell, Johannes Sperzel, Bernard Thibault, Christopher A Rinaldi, Carlo Pappone, Klaus-Jürgen Gutleben, Christopher Leclercq, Hedi Razavi, Kyungmoo Ryu, Luke C Mcspadden, Avi Fischer, Gery Tomassoni
Aims: The aim of this study was to evaluate any benefits to the number of viable pacing vectors and maximal spatial coverage with quadripolar left ventricular (LV) leads when compared with tripolar and bipolar equivalents in patients receiving cardiac resynchronization therapy (CRT). Methods and Results: A meta-analysis of five previously published clinical trials involving the Quartet™ LV lead (St Jude Medical, St Paul, MN, USA) was performed to evaluate the number of viable pacing vectors defined as capture thresholds ≤2...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28427882/effects-of-bystander-cpr-following-out-of-hospital-cardiac-arrest-on-hospital-costs-and-long-term-survival
#6
Guillaume Geri, Carol Fahrenbruch, Hendrika Meischke, Ian Painter, Lindsay White, Thomas D Rea, Marcia R Weaver
BACKGROUND: Bystander cardiopulmonary resuscitation (CPR) is associated with a greater likelihood of survival to hospital discharge after out-of-hospital cardiac arrest (OHCA). However the long-term survival benefits in relationship to cost have not been well-studied. We evaluated bystander CPR, hospital-based costs, and long-term survival following OHCA in order to assess the potential cost-effectiveness of bystander CPR. PATIENTS AND METHODS: We conducted a retrospective cohort study of consecutive EMS-treated OHCA patients >=12years who arrested prior to EMS arrival and outside a nursing facility between 2001 and 2010 in greater King County, WA...
April 18, 2017: Resuscitation
https://www.readbyqxmd.com/read/28414226/testing-the-push-pull-hypothesis-lewis-acid-augmented-n2-activation-at-iron
#7
Jacob B Geri, James P Shanahan, Nathaniel K Szymczak
We present a systematic investigation of the structural and electronic changes that occur in an Fe(0)-N2 unit (Fe(depe)2(N2); depe = 1,2-bis(diethylphosphino)ethane) upon the addition of exogenous Lewis acids. Addition of neutral boranes, alkali metal cations, and an Fe(2+) complex increases the N-N bond activation (Δ νNN up to 172 cm(-1)), decreases the Fe(0)-N2 redox potential, polarizes the N-N bond, and enables -N protonation at uncommonly anodic potentials. These effects were rationalized using combined experimental and theoretical studies...
April 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28403393/estimated-cost-of-emergency-sunburn-visits-reply
#8
Gery P Guy, Zahava Berkowitz, Meg Watson
No abstract text is available yet for this article.
April 12, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28395992/does-transport-time-of-out-of-hospital-cardiac-arrest-patients-matter-a-systematic-review-and-meta-analysis
#9
REVIEW
Guillaume Geri, Joshua Gilgan, Wen Wu, Sandy Vijendira, Carolyn Ziegler, Ian R Drennan, Laurie Morrison, Steve Lin
BACKGROUND: Despite increasing evidence for specialized cardiac arrest centers, the impact of transport time on out-of-hospital cardiac arrest (OHCA) patients' outcome remains unclear. We systematically reviewed the prognostic impact of transport time in OHCA patients. METHODS: We searched PubMed, Embase, the Cochrane Library, and Web of Science from inception to May 2016 for studies that had reported the relationship between transport time and outcome in OHCA patients...
April 8, 2017: Resuscitation
https://www.readbyqxmd.com/read/28395263/spatial-and-temporal-patterns-of-soil-water-storage-and-vegetation-water-use-in-humid-northern-catchments
#10
Josie Geris, Doerthe Tetzlaff, Jeffrey J McDonnell, Chris Soulsby
Using stable isotope data from soil and vegetation xylem samples across a range of landscape positions, this study provides preliminary insights into spatial patterns and temporal dynamics of soil-plant water interactions in a humid, low-energy northern environment. Our analysis showed that evaporative fractionation affected the isotopic signatures in soil water at shallow depths but was less marked than previously observed in other environments. By comparing the temporal dynamics of stable isotopes in soil water mainly held at suctions around and below field capacity, we found that these waters are not clearly separated...
April 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28393638/vascular-territorial-segmentation-and-volumetric-blood-flow-measurement-using-dynamic-contrast-enhanced-magnetic-resonance-angiography-of-the-brain
#11
Oren Geri, Shelly I Shiran, Jonathan Roth, Moran Artzi, Liat Ben-Sira, Dafna Ben Bashat
This study proposes a method for territorial segmentation and volumetric flow rate (VFR) distribution measurement of cerebral territories based on time-resolved contrast enhanced magnetic-resonance-angiography (MRA). The method uses an iterative region-growing algorithm based on bolus-arrival-time with increased temporal resolution. Eight territories were segmented: (1) right and (2) left internal carotid arteries, including the middle cerebral artery (ICA+MCA), excluding the anterior cerebral arteries (ACA); (3) right and left ACA (R+L-ACA); (4) right and (5) left external carotid arteries (ECA); (6) right and (7) left posterior cerebral arteries (PCA); and (8) vertebrobasilar territory...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28382598/patients-with-anca-associated-vasculitis-admitted-to-the-intensive-care-unit-with-acute-vasculitis-manifestations-a-retrospective-and-comparative-multicentric-study
#12
Julien Demiselle, Johann Auchabie, François Beloncle, Philippe Gatault, Steven Grangé, Damien Du Cheyron, Jean Dellamonica, Sonia Boyer, Dimitri Titeca Beauport, Lise Piquilloud, Julien Letheulle, Christophe Guitton, Nicolas Chudeau, Guillaume Geri, François Fourrier, René Robert, Emmanuel Guérot, Julie Boisramé-Helms, Pierre Galichon, Pierre-François Dequin, Alexandre Lautrette, Pierre-Edouard Bollaert, Ferhat Meziani, Loïc Guillevin, Nicolas Lerolle, Jean-François Augusto
PURPOSE: Data for ANCA-associated vasculitis (AAV) patients requiring intensive care are scarce. METHODS: We included 97 consecutive patients with acute AAV manifestations (new onset or relapsing disease), admitted to 18 intensive care units (ICUs) over a 10-year period (2002-2012). A group of 95 consecutive AAV patients with new onset or relapsing disease, admitted to two nephrology departments with acute vasculitis manifestations, constituted the control group...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28382396/retrospective-evaluation-of-concomitant-cetuximab-and-radiotherapy-tolerance-for-locoregional-advanced-head-and-neck-squamous-cell-carcinoma-treatment-in-patients-unfit-for-platinum-based-chemotherapy
#13
Audrey Rambeau, Radj Gervais, Dominique De Raucourt, Emmanuel Babin, Audrey Emmanuelle Dugué, Carmen Florescu, David Blanchard, Bernard Gery
Radiotherapy associated with cetuximab (Cet-RT) is an alternative treatment to platinum-based chemoradiotherapy in locally advanced head and neck carcinoma (LAHNC). Reviews suggest that the use of cetuximab is associated with poorer tolerance in patients unfit for chemotherapy than in pivotal trial. We retrospectively studied patients first treated by Cet-RT for LAHNC presenting contraindications to chemoradiotherapy. Objectives were treated population description, acute tolerance, progression-free survival (PFS), overall survival (OS), and 3-month clinical response...
April 5, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28380476/vaginal-neoplasia-induced-by-an-unusual-papillomavirus-subtype-in-a-woman-with-inherited-chromosomally-integrated-human-herpesvirus-type-6a
#14
Maxime Pichon, Alexandre Gaymard, Karine Lebail-Carval, Emilie Frobert, Etienne Beaufils, Gautier Chene, Massimo Tommasino, Bruno Lina, Pascal Gaucherand, Agnès Gautheret-Dejean, Pascale Bonnafous, Tarik Gheit, Annie Buenerd, Gery Lamblin, Yahia Mekki
We describe here a case of high-grade vaginal squamous lesion in a 54-year-old woman with a papillomaviruses (HPV) genital infection that developed from a cervical low-grade squamous intraepithelial lesion (SIL) to a high-grade SIL (H-SIL) on cytological examination. A colposcopy exam led to the detection of suspect vaginal lesions with granulomatous infiltrations, which were classified as a Vaginal Intra-Epithelial Neoplasia grade 2 after pathologists' analyses. After a laser vaginal surgery and a loop excision of the transformation zone, the analyses of the anatomical pieces using a near-complete HPV screening panel revealed an HPV-4 infection that was not detected before in cervical smears...
April 6, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28372839/orthogonal-lc-ms-methods-for-the-comprehensive-characterization-of-therapeutic-glycoproteins-from-released-glycans-to-intact-protein-level
#15
Eric Largy, Fabrice Cantais, Géry Van Vyncht, Alain Beck, Arnaud Delobel
Proteins are increasingly used as therapeutics. Their characterization is challenging due to their size and inherent heterogeneity notably caused by post-translational modifications, among which glycosylation is probably the most prominent. The glycosylation profile of therapeutic proteins must therefore be thoroughly analyzed. Here, we illustrate how the use of a combination of various cutting-edge LC or LC/MS(/MS) methods, and operating at different levels of analysis allows the comprehensive characterization of both the N- and O-glycosylations of therapeutic proteins without the need for other approaches (capillary electrophoresis, MALDI-TOF)...
March 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28360123/impact-of-positive-pressure-ventilation-on-mean-systemic-filling-pressure-in-critically-ill-patients-after-death
#16
Xavier Repessé, Cyril Charron, Guillaume Geri, Alix Aubry, Alexis Paternot, Julien Maizel, Michel Slama, Antoine Vieillard-Baron
Introduction Mean systemic filling pressure (Pms) defines the pressure measured in the venous-arterial system when the cardiac output is nil. Its estimation has been proposed in patients with beating hearts by building the venous return curve, using different pairs of right atrial pressure/cardiac output during mechanical ventilation. We raised the hypothesis according to which the Pms is altered by tidal ventilation and PEEP, which would challenge this extrapolation method based on cardiopulmonary interactions...
March 30, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28343661/variability-in-surgical-management-of-benign-ovarian-neoplasms-in-children
#17
Dani O Gonzalez, Jennifer N Cooper, Jennifer H Aldrink, Geri D Hewitt, Mary E Fallat, Peter C Minneci, Katherine J Deans
BACKGROUND/PURPOSE: Although most pediatric ovarian neoplasms are benign and may be treated with ovary-sparing surgery (OSS), consensus is lacking on the optimal surgical approach. We aimed to determine the proportion of pediatric benign ovarian neoplasms managed with OSS and to assess variability in management across hospitals and specialties. METHODS: Using the Pediatric Health Information System, we studied patients aged 6-21 years treated in 2006-2014 for a benign ovarian neoplasm with oophorectomy or OSS...
March 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28339546/multicentre-safety-of-adding-focal-impulse-and-rotor-modulation-firm-to-conventional-ablation-for-atrial-fibrillation
#18
David E Krummen, Tina Baykaner, Amir A Schricker, Christopher A B Kowalewski, Vijay Swarup, John M Miller, Gery F Tomassoni, Shirley Park, Mohan N Viswanathan, Paul J Wang, Sanjiv M Narayan
Aims: Focal Impulse and Rotor Modulation (FIRM) uses 64-electrode basket catheters to identify atrial fibrillation (AF)-sustaining sites for ablation, with promising results in many studies. Accordingly, new basket designs are being tested by several groups. We set out to determine the procedural safety of adding basket mapping and map-guided ablation to conventional pulmonary vein isolation (PVI). Methods and results: We collected 30 day procedural safety data in five US centres for consecutive patients undergoing FIRM plus PVI (FIRM-PVI) compared with contemporaneous controls undergoing PVI without FIRM...
December 22, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28336564/identification-of-a-novel-syk-c-myc-malat1-signaling-pathway-and-its-potential-therapeutic-value-in-ewing-sarcoma
#19
Haibo Sun, De-Chen Lin, Qi Cao, Brendan Pang, David D Gae, Victor Km Lee, Huey Jin Lim, Ngan Doan, Jonathan W Said, Sigal Gery, Marilynn Chow, Anand Mayakonda, Charles Forscher, Jeffrey W Tyner, H Phillip Koeffler
PURPOSE: Ewing Sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TKs) and associated pathways are continuously activated in many malignancies including EWS; these enzymes provide candidate therapeutic targets. EXPERIMENTAL DESIGN: Two high-throughput screens (a siRNA library and a small-molecule inhibitor library) were performed in EWS cells to establish candidate targets. Spleen tyrosine kinase (SYK) phosphorylation was assessed in EWS patients and cell lines...
March 23, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28334374/chronic-systemic-interleukin-18-does-not-promote-macular-degeneration-or-choroidal-neovascularization
#20
Scott W Canna, Guangpu Shi, Igal Gery, H Nida Sen
No abstract text is available yet for this article.
March 1, 2017: Investigative Ophthalmology & Visual Science
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