keyword
https://read.qxmd.com/read/38509096/reciprocal-inhibition-between-tp63-and-stat1-regulates-anti-tumor-immune-response-through-interferon-%C3%AE-signaling-in-squamous-cancer
#1
JOURNAL ARTICLE
Yuan Jiang, Yueyuan Zheng, Yuan-Wei Zhang, Shuai Kong, Jinxiu Dong, Fei Wang, Benjamin Ziman, Sigal Gery, Jia-Jie Hao, Dan Zhou, Jianian Zhou, Allen S Ho, Uttam K Sinha, Jian Chen, Shuo Zhang, Chuntong Yin, Dan-Dan Wei, Masaharu Hazawa, Huaguang Pan, Zhihao Lu, Wen-Qiang Wei, Ming-Rong Wang, H Phillip Koeffler, De-Chen Lin, Yan-Yi Jiang
Squamous cell carcinomas (SCCs) are common and aggressive malignancies. Immune check point blockade (ICB) therapy using PD-1/PD-L1 antibodies has been approved in several types of advanced SCCs. However, low response rate and treatment resistance are common. Improving the efficacy of ICB therapy requires better understanding of the mechanism of immune evasion. Here, we identify that the SCC-master transcription factor TP63 suppresses interferon-γ (IFNγ) signaling. TP63 inhibition leads to increased CD8+ T cell infiltration and heighten tumor killing in in vivo syngeneic mouse model and ex vivo co-culture system, respectively...
March 20, 2024: Nature Communications
https://read.qxmd.com/read/38501998/reply-to-chang-et-al
#2
JOURNAL ARTICLE
S Michaela Rikard, Nisha Nataraj, Kun Zhang, Andrea Strahan, Christina A Mikosz, Gery P Guy
No abstract text is available yet for this article.
April 1, 2024: Pain
https://read.qxmd.com/read/38494422/editorial-for-the-cell-energetics-cell-mechanics-themed-issues
#3
EDITORIAL
René Marc Mège, Geri Kreitzer
No abstract text is available yet for this article.
March 17, 2024: Biology of the Cell
https://read.qxmd.com/read/38491534/a-novel-machine-learning-framework-based-on-early-embryo-morphokinetics-identifies-a-feature-signature-associated-with-blastocyst-development
#4
JOURNAL ARTICLE
S Canosa, N Licheri, L Bergandi, G Gennarelli, C Paschero, M Beccuti, D Cimadomo, G Coticchio, L Rienzi, C Benedetto, F Cordero, A Revelli
BACKGROUND: Artificial Intelligence entails the application of computer algorithms to the huge and heterogeneous amount of morphodynamic data produced by Time-Lapse Technology. In this context, Machine Learning (ML) methods were developed in order to assist embryologists with automatized and objective predictive models able to standardize human embryo assessment. In this study, we aimed at developing a novel ML-based strategy to identify relevant patterns associated with the prediction of blastocyst development stage on day 5...
March 15, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38483013/a-bibliometric-analysis-of-the-quantitative-schema-therapy-literature
#5
REVIEW
Pamela D Pilkington, Gery C Karantzas
BACKGROUND: The evidence base for schema therapy has evolved significantly since it was first developed by Jeffrey Young in the 1990s. The aim of this bibliometric analysis was to summarize the trends and characteristics of the quantitative literature on schema therapy. METHOD: PsycINFO, PubMed and CINAHL Complete databases were last searched on 1 June 2023 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement to identify peer-reviewed journal articles written in English that reported on original quantitative research on schema therapy or schema therapy constructs...
2024: Clinical Psychology & Psychotherapy
https://read.qxmd.com/read/38472006/implementation-of-a-geriatric-care-bundle-for-older-adults-with-acute-burns
#6
JOURNAL ARTICLE
Julia Oehlers, Carolyn Blayney, Jo Tate, Alexander Cheng, Andrew Tucker, May J Reed, Barclay T Stewart, Saman Arbabi, Kathleen O'Connell, Elisabeth Powelson, Tam N Pham
BACKGROUND: Frailty and comorbidities are important outcome determinants in older patients (age ≥65) with burns. A Geriatric Burn Bundle (Geri-B) was implemented in 2019 at a regional burn center to standardize care for older adults. Components included frailty screening and protocolized geriatric co-management, malnutrition screening with nutritional support, and geriatric-centered pain regimens. METHODS: This study aimed to qualitatively evaluate the implementation of Geri-B using the Proctor Framework...
February 29, 2024: Burns
https://read.qxmd.com/read/38451718/psychometrics-of-the-children-s-report-of-parental-behavior-inventory-among-caregivers-and-youth-with-hiv
#7
JOURNAL ARTICLE
Violeta J Rodriguez, Ashley D Kendall, Mardge H Cohen, Sabin Nsanzimana, Charles Ingabire, Eric Remera, Geri Donenberg
Parenting has been implicated in a range of youth health outcomes. Positive parenting during adolescence, a critical period of developmental change, may equip youth with the necessary tools for their transition into adulthood and, for youth living with HIV, their transition from pediatric HIV care into adult HIV care. Yet, because few studies have carefully assessed the psychometric properties of parenting instruments applied cross-culturally, the validity of parenting research derived in these contexts remains unclear...
March 7, 2024: Journal of Family Psychology: JFP
https://read.qxmd.com/read/38445252/redefining-pandemic-preparedness-multidisciplinary-insights-from-the-cerp-modelling-workshop-in-infectious-diseases-workshop-report
#8
REVIEW
Marta C Nunes, Edward Thommes, Holger Fröhlich, Antoine Flahault, Julien Arino, Marc Baguelin, Matthew Biggerstaff, Gaston Bizel-Bizellot, Rebecca Borchering, Giacomo Cacciapaglia, Simon Cauchemez, Alex Barbier-Chebbah, Carsten Claussen, Christine Choirat, Monica Cojocaru, Catherine Commaille-Chapus, Chitin Hon, Jude Kong, Nicolas Lambert, Katharina B Lauer, Thorsten Lehr, Cédric Mahe, Vincent Marechal, Adel Mebarki, Seyed Moghadas, Rene Niehus, Lulla Opatowski, Francesco Parino, Gery Pruvost, Andreas Schuppert, Rodolphe Thiébaut, Andrea Thomas-Bachli, Cecile Viboud, Jianhong Wu, Pascal Crépey, Laurent Coudeville
In July 2023, the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 pandemic. This report summarizes the rich discussions that occurred during the workshop. The workshop participants discussed multisource data integration and highlighted the benefits of combining traditional surveillance with more novel data sources like mobility data, social media, and wastewater monitoring. Significant advancements were noted in the development of predictive models, with examples from various countries showcasing the use of machine learning and artificial intelligence in detecting and monitoring disease trends...
June 2024: Infectious Disease Modelling
https://read.qxmd.com/read/38408608/-pediatric-atlas-anatomy-and-its-implications-for-fracture-treatment-an-anatomical-and-radiological-study-es-anatom%C3%A3-a-del-atlas-pedi%C3%A3-trico-y-sus-implicaciones-en-el-tratamiento-de-fracturas-un-estudio-anat%C3%A3-mico-y-radiol%C3%A3-gico
#9
JOURNAL ARTICLE
Lucie Salavcová, Jan Štulík, Vojtěch Štulík, Michaela Rybárová, Gábor Geri, Ondřej Naňka
INTRODUCTION AND OBJECTIVES: The objective of the study was: (1) to describe changes in the shape of the atlas during growth, including gender and side differences; (2) to assess the dimension essential for identification of the optimal entry point; (3) to determine the age limit for a safe insertion of 3.5-mm screws into the lateral masses according to our own limiting parameters. MATERIALS AND METHODS: Dimensions of the atlas were measured on 200 CT scans of the craniocervical junction in individuals aged 0 to18 years and on 34 anatomical specimens of the first cervical vertebra (aged 2...
February 24, 2024: Neurocirugía (English Edition)
https://read.qxmd.com/read/38407824/renal-replacement-therapy-initiation-strategies-in-comatose-patients-with-severe-acute-kidney-injury-a-secondary-analysis-of-a-multicenter-randomized-controlled-trial
#10
JOURNAL ARTICLE
Thomas Rambaud, David Hajage, Didier Dreyfuss, Saïd Lebbah, Laurent Martin-Lefevre, Guillaume Louis, Sébastien Moschietto, Dimitri Titeca-Beauport, Béatrice La Combe, Bertrand Pons, Nicolas De Prost, Sébastien Besset, Alain Combes, Adrien Robine, Marion Beuzelin, Julio Badie, Guillaume Chevrel, Julien Bohe, Elisabeth Coupez, Nicolas Chudeau, Saber Barbar, Christophe Vinsonneau, Jean-Marie Forel, Didier Thevenin, Eric Boulet, Karim Lakhal, Nadia Aissaoui, Steven Grange, Marc Leone, Guillaume Lacave, Saad Nseir, Florent Poirson, Julien Mayaux, Karim Ashenoune, Guillaume Geri, Kada Klouche, Guillaume Thiery, Laurent Argaud, Bertrand Rozec, Cyril Cadoz, Pascal Andreu, Jean Reignier, Jean-Damien Ricard, Jean-Pierre Quenot, Romain Sonneville, Stéphane Gaudry
PURPOSE: The effect of renal replacement therapy (RRT) in comatose patients with acute kidney injury (AKI) remains unclear. We compared two RRT initiation strategies on the probability of awakening in comatose patients with severe AKI. METHODS: We conducted a post hoc analysis of a trial comparing two delayed RRT initiation strategies in patients with severe AKI. Patients were monitored until they had oliguria for more than 72 h and/or blood urea nitrogen higher than 112 mg/dL and then randomized to a delayed strategy (RRT initiated after randomization) or a more-delayed one (RRT initiated if complication occurred or when blood urea nitrogen exceeded 140 mg/dL)...
February 26, 2024: Intensive Care Medicine
https://read.qxmd.com/read/38402462/factors-associated-with-transitions-in-tobacco-product-use-states-among-young-adults-aged-18-29-years
#11
JOURNAL ARTICLE
Melissa D Blank, Nicholas A Turiano, Bethany C Bray, Andrea R Milstred, Margaret Childers, Geri Dino, Katelyn F Romm
BACKGROUND AND OBJECTIVES: This study examined young adults' tobacco use transitions based on their past 30-day use states, and identified factors associated with their transitions. METHODS: Participants (N = 12377) were young adults aged 18-29 years at Wave 1 of the Population Assessment of Tobacco and Health (PATH) study. Self-reported tobacco use states were categorized by the number of past-month use days (0, 1-4, 5-8, 9-12, 13-30 days) for cigarettes, electronic cigarettes [e-cigarettes], traditional cigars, filtered cigars, cigarillos, smokeless tobacco (SLT), and hookah...
February 25, 2024: American Journal on Addictions
https://read.qxmd.com/read/38392767/a-review-about-the-mycoremediation-of-soil-impacted-by-war-like-activities-challenges-and-gaps
#12
REVIEW
Regina Geris, Marcos Malta, Luar Aguiar Soares, Lourdes Cardoso de Souza Neta, Natan Silva Pereira, Miguel Soares, Vanessa da Silva Reis, Madson de Godoi Pereira
(1) Background: The frequency and intensity of war-like activities (war, military training, and shooting ranges) worldwide cause soil pollution by metals, metalloids, explosives, radionuclides, and herbicides. Despite this environmentally worrying scenario, soil decontamination in former war zones almost always involves incineration. Nevertheless, this practice is expensive, and its efficiency is suitable only for organic pollutants. Therefore, treating soils polluted by wars requires efficient and economically viable alternatives...
January 24, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38391470/development-of-3d-printed-pnipam-chitosan-scaffolds-for-dentoalveolar-tissue-engineering
#13
JOURNAL ARTICLE
Mehdi Salar Amoli, Resmi Anand, Mostafa EzEldeen, Liesbet Geris, Reinhilde Jacobs, Veerle Bloemen
While available treatments have addressed a variety of complications in the dentoalveolar region, associated challenges have resulted in exploration of tissue engineering techniques. Often, scaffold biomaterials with specific properties are required for such strategies to be successful, development of which is an active area of research. This study focuses on the development of a copolymer of poly (N-isopropylacrylamide) (pNIPAM) and chitosan, used for 3D printing of scaffolds for dentoalveolar regeneration...
February 12, 2024: Gels
https://read.qxmd.com/read/38384778/modelling-the-emergence-of-social-bird-biological-controls-to-mitigate-invasions-of-the-spotted-lanternfly-and-similar-invasive-pests
#14
JOURNAL ARTICLE
Daniel Strömbom, Amanda Crocker, Alison Gery, Grace Tulevech, Autumn Sands, Kelly Ward, Swati Pandey
The spotted lanternfly is an emerging global invasive insect pest. Due to a lack of natural enemies where it is invasive, human intervention is required. Extensive management has been applied but the spread continues. Recently, the idea of bird-based biological controls has re-emerged and shown effective in studies. However, it is questionable, if birds are able to effectively control unfamiliar and occasionally toxic invasive pests in short timeframes. Unless, perhaps, the birds are effective social learners and toxicity of the invaders is rare...
February 2024: Royal Society Open Science
https://read.qxmd.com/read/38381536/arm-cooling-selectively-impacts-sensorimotor-control
#15
JOURNAL ARTICLE
Cecile R Scotto, Florian Petitcollin, Olivier Dupuy, Géry Casiez, Benoit Dugué, Lucette Toussaint
The benefits of cold have long been recognized in sport and medicine. However, it also brings costs, which have more rarely been investigated, notably in terms of sensorimotor control. We hypothesized that in addition to peripheral effects, cold slows down the processing of proprioceptive cues, which has an impact on both feedback and feedforward control. We therefore compared the performances of participants whose right arm had been immersed in either cold water (arm temperature: 14°C) or lukewarm water (arm temperature: 34°C)...
February 21, 2024: Journal of Neurophysiology
https://read.qxmd.com/read/38335028/previous-strategic-culture-media-design-to-boost-fungal-secondary-metabolite-biosynthesis-and-cyborg-cell-growth-current-exploiting-the-diversity-of-culture-media-to-produce-fungal-secondary-metabolites-and-cyborg-cells
#16
JOURNAL ARTICLE
Regina Geris, Marcos Malta, Antonio Ferreira da Silva, Vitoria Evelyn Teles de Jesus
Fungi are microorganisms of significant biotechnological importance due to their ability to provide food and produce several value-added secondary metabolites and enzymes. Its products move billions of dollars in the pharmaceutical, cosmetics, and additives sectors. These microorganisms also play a notable role in bionanotechnology, leading to the production of hybrid biological-inorganic materials (such as cyborg cells) and the use of their enzyme complex in the biosynthesis of nanoparticles. In this sense, optimizing the fungal growth process is necessary, with selecting the cultivation medium as one of the essential factors for the microorganism to reach its maximum metabolic expression...
February 9, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38331319/barriers-to-retention-in-medications-for-opioid-use-disorder-treatment-in-real-world-practice
#17
JOURNAL ARTICLE
Vanessa I Villamil, Natasha Underwood, Laura J Cremer, Cherie R Rooks-Peck, Xinyi Jiang, Gery P Guy
BACKGROUND: Medications for Opioid Use Disorder (MOUD) are an effective method to treat persons with opioid use disorder (OUD). Longer treatment times are associated with better health outcomes, yet treatment retention rates remain low. This study aimed to assess patient characteristics and experiences associated with retention in treatment. METHODS: Data were from an observational cohort study of OUD treatments. Among persons receiving buprenorphine or methadone, log-binomial regression models assessed the relationship between patient characteristics and experiences and three retention outcomes: retention in any OUD treatment, retention in the index treatment (OUD treatment being administered at the time when patients were screened for study eligibility), and 6-month retention in the index treatment...
February 7, 2024: J Subst Use Addict Treat
https://read.qxmd.com/read/38329914/characteristics-of-alcohol-marijuana-and-other-drug-use-among-persons-aged-13-18-years-being-assessed-for-substance-use-disorder-treatment-united-states-2014-2022
#18
JOURNAL ARTICLE
Sarah Connolly, Taryn Dailey Govoni, Xinyi Jiang, Andrew Terranella, Gery P Guy, Jody L Green, Christina Mikosz
Substance use often begins during adolescence, placing youths at risk for fatal overdose and substance use disorders (SUD) in adulthood. Understanding the motivations reported by adolescents for using alcohol, marijuana, and other drugs and the persons with whom they use these substances could guide strategies to prevent or reduce substance use and its related consequences among adolescents. A cross-sectional study was conducted among adolescents being assessed for SUD treatment in the United States during 2014-2022, to examine self-reported motivations for using substances and the persons with whom substances were used...
February 8, 2024: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/38328919/a-systemic-review-of-the-difference-between-diets-for-preterm-infants-containing-raw-mother-s-own-milk-and-frozen-or-pasteurized-mother-s-own-milk
#19
REVIEW
Jessica Ann Gomez, Karla Abela, Geri LoBiondo-Wood
BACKGROUND: Raw, never stored or pasteurized mother's own milk (MOM) is not always available to feed preterm infants; however, storage and pasteurization of MOM diminishes some bioactive components. It can be difficult to feed raw MOM to preterm infants due to transportation and storage of small volumes that might be pumped away from the infant, and a concern that they might harbor bacteria. However, the higher availability of bioactive components in raw MOM may provide benefits to preterm infants compared to frozen or pasteurized MOM...
February 8, 2024: Journal of Human Lactation
https://read.qxmd.com/read/38317262/antibiotic-definitive-treatment-in-ventilator-associated-pneumonia-caused-by-ampc-producing-enterobacterales-in-critically-ill-patients-a-prospective-multicenter-observational-study
#20
MULTICENTER STUDY
Matthieu Petit, Frank Bidar, Quentin Fosse, Lucie Lefevre, Marine Paul, Tomas Urbina, Paul Masi, Florent Bavozet, Jérémie Lemarié, Etienne de Montmollin, Chloé Andriamifidy-Berti, Julien Dessajan, Benjamin Zuber, Lara Zafrani, Edwige Peju, Paris Meng, Liliane Charrier, Loic Le Guennec, Marie Simon, Charles-Edouard Luyt, Luc Haudebourg, Guillaume Geri
BACKGROUND: Ventilator associated pneumonia (VAP) due to wild-type AmpC-producing Enterobacterales (wtAE) is frequent in intensive care unit (ICU) patients. Despite a low level of evidence, definitive antimicrobial therapy (AMT) with third generation cephalosporins (3GCs) or piperacillin is discouraged. METHODS: Observational prospective study including consecutive wtAE VAP patients in 20 French ICUs. The primary objective was to assess the association of the choice of definitive AMT, i...
February 5, 2024: Critical Care: the Official Journal of the Critical Care Forum
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