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https://www.readbyqxmd.com/read/29927611/in-silico-and-in-vitro-assessment-of-oatp1b1-inhibition-in-drug-discovery
#1
Matthew L Danielson, Geri A Sawada, Thomas J Raub, Prashant V Desai
The organic anion-transporting polypeptide 1B1 transporter belongs to the solute carrier superfamily and is highly expressed at the basolateral membrane of hepatocytes. Several clinical studies showed drug-drug interactions involving OATP1B1 thereby prompting the International Transporter Consortium to label OATP1B1 as a critical transporter that can influence a compound's disposition. To examine OATP1B1 inhibition early in the drug discovery process, we established a medium-throughput concentration-dependent OATP1B1 assay...
June 21, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29924147/assessment-of-health-functioning-of-older-adults-who-consume-psychoactive-substances
#2
Vania Dias Cruz, Silvana Sidney Costa Santos, Jamila Geri Tomaschewski-Barlem, Bárbara Tarouco da Silva, Celmira Lange, Daiane Porto Gautério de Abreu, Flávia Seles Oliveira
OBJECTIVE: To assess the health/functioning of the older adult who consumes psychoactive substances through the International Classification of Functioning, Disability and Health, considering the theory of complexity. METHOD: Qualitative case study, with 11 older adults, held between December 2015 and February 2016 in the state of Rio Grande do Sul, using interviews, documents and non-systematic observation. It was approved by the ethics committee. The analysis followed the propositions of the case study, using the complexity of Morin as theoretical basis...
May 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29910594/the-longitudinal-impact-of-a-family-based-communication-intervention-on-observational-and-self-reports-of-sexual-communication
#3
Wendy Hadley, Amy Lansing, David H Barker, Larry K Brown, Heather Hunter, Geri Donenberg, Ralph J DiClemente
Parents can play a vital role in shaping teenagers' sexual attitudes, behavior, and contraceptive use through communication, however, less is known about how to modify parent-adolescent communication among youth with mental health problems. The impact of a family-based sexual risk prevention intervention on both observational and self-report of parent adolescent sexual communication was examined at 12-months among adolescents with mental health problems. Of the 721 parent- adolescent dyads recruited for the study, 167 videotapes of sexual discussions between parents and adolescent were coded for the family-based intervention and 191 videotapes for the active comparison...
April 2018: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29902865/co-targeting-poly-adp-ribose-polymerase-parp-and-histone-deacetylase-hdac-in-triple-negative-breast-cancer-higher-synergism-in-brca-mutated-cells
#4
Hélène Marijon, Dhong Hyun Lee, LingWen Ding, Haibo Sun, Sigal Gery, Aimery de Gramont, H Phillip Koeffler
PURPOSE: Despite similarities with BRCA-mutated breast cancers, triple-negative breast cancers (TNBC) remain resistant to poly(ADP-ribose) polymerase (PARP) inhibitors as single agents. Histone deacetylase inhibitors (HDACi) can decrease expression of proteins involved in DNA repair. We thus hypothesized that a HDACi (suberoylanilide hydroxamic acid (SAHA) or belinostat) could sensitize TNBC to the PARP inhibitor olaparib. METHODS: Human TNBC cells were co-treated with olaparib and either SAHA or belinostat, and their effects on survival, proliferation, cell cycle, apoptosis and DNA repair pathways were evaluated...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29890903/self-efficacy-and-ability-to-read-as-factors-associated-with-antiretroviral-therapy-adherence-in-an-hiv-infected-population
#5
Mark S Dworkin, Apurba Chakraborty, Diana Zychowski, Geri Donenberg, Richard Novak, Robert Garofalo
Determining the barriers and facilitators of antiretroviral adherence among former and current substance users may be useful in the creation of successful interventions that target this hard-to-reach population. We performed a cross-sectional study of HIV-infected patients (N = 123) prescribed antiretroviral therapy at four Chicago healthcare venues. Bivariate and multivariable analyses were performed to determine factors associated with non-adherence based on definitions of non-adherence (any missed doses) within the past 4-day, 14-day, and 1-month time periods...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29884609/the-general-practitioner-prompt-study-to-reduce-cardiovascular-and-renal-complications-in-patients-with-type-2-diabetes-and-renal-complications-protocol-and-baseline-characteristics-for-a-cluster-randomized-controlled-trial
#6
Andrew Willis, Winston Crasto, Laura Gray, Helen Dallosso, Ghazala Waheed, Geri Gray, Melanie J Davies, Kamlesh Khunti
BACKGROUND: Adherence to evidence-based cardiovascular risk factor targets in patients with type 2 diabetes and microalbuminuria has shown long-term reduction in mortality and morbidity. Strategies to achieve such adherence have been delivered at individual patient level and are not cost-effective. Health care professional-level intervention has the potential to promote better adherence at lower cost. OBJECTIVE: The aim of this study was to assess the effectiveness of a multifactorial technology-driven intervention comprising health care professional training, a software prompt installed on practice systems, clinician email support, and enhanced performance and feedback reporting...
June 8, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29878867/improved-outcome-by-adding-concurrent-chemotherapy-to-cetuximab-and-radiotherapy-for-locally-advanced-head-and-neck-carcinomas-results-of-the-gortec-2007-01-phase-iii-randomized-trial
#7
Yungan Tao, Anne Auperin, Christian Sire, Laurent Martin, Cedric Khoury, Philippe Maingon, Etienne Bardet, Marie-Christine Kaminsky, Michel Lapeyre, Thierry Chatellier, Marc Alfonsi, Yoann Pointreau, Eric Jadaud, Bernard Géry, Ayman Zawadi, Jean-Marc Tourani, Brigitte Laguerre, Alexandre Coutte, Séverine Racadot, Ali Hasbini, Emanuelle Malaurie, Christian Borel, Nicolas Meert, Alexandre Cornely, Nathalie Ollivier, Odile Casiraghi, Xu Shan Sun, Jean Bourhis
Purpose To investigate the effect of adding concurrent chemotherapy (CT) to cetuximab plus radiotherapy (RT; CT-cetux-RT) compared with cetuximab plus RT (cetux-RT) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). Patients and Methods In this phase III randomized trial, patients with N0-2b, nonoperated, stage III or IV (nonmetastatic) LA-SCCHN were enrolled. Patients received once-daily RT up to 70 Gy with weekly cetuximab or with weekly cetuximab and concurrent carboplatin and fluorouracil (three cycles)...
June 7, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29852197/prognostic-value-of-adrenal-gland-volume-after-cardiac-arrest-association-of-ct-scan-evaluation-with-shock-and-mortality
#8
Nicolas Mongardon, Guillaume Savary, Guillaume Geri, Marie-Rose El Bejjani, Stéphane Silvera, Florence Dumas, Julien Charpentier, Frédéric Pène, Jean-Paul Mira, Alain Cariou
BACKGROUND: Adrenal gland volume is associated with survival in septic shock. As sepsis and post-cardiac arrest syndrome share many pathophysiological features, we assessed the association between adrenal gland volume measured by computerized tomography (CT)-scan and post-cardiac arrest shock and intensive care unit (ICU) mortality, in a large cohort of out-of-hospital cardiac arrest (OHCA) patients. We also investigated the association between adrenal hormonal function and both adrenal gland volume and outcomes...
May 28, 2018: Resuscitation
https://www.readbyqxmd.com/read/29846551/epstein-barr-virus-dna-in-parental-oral-secretions-a-potential-source-of-infection-for-their-young-children
#9
Laurel E Cederberg, Mark D Rabinovitch, Jennifer M Grimm-Geris, David O Schmeling, Emma A Filtz, Lawrence M Condon, Henry H Balfour
Background: A potential source of primary Epstein-Barr virus (EBV) infection for young children is parental oral secretions. If parents who identify with racial/ethnic categories other than white have a higher prevalence of oral EBV DNA, this difference could explain why their children acquire primary EBV infection at an earlier age than white children. Methods: To test this hypothesis, we recruited parents who brought their children <8 years old to routine clinic visits and tested their oral washes for EBV DNA by real-time PCR...
May 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29784451/randomized-trial-comparing-two-methods-of-re-irradiation-after-salvage-surgery-in-head-and-neck-squamous-cell-carcinoma-once-daily-split-course-radiotherapy-with-concomitant-chemotherapy-or-twice-daily-radiotherapy-with-cetuximab
#10
Yungan Tao, Laura Faivre, Anne Laprie, Pierre Boisselier, Christophe Ferron, Guy Michel Jung, Séverine Racadot, Bernard Gery, Caroline Even, Ingrid Breuskin, Jean Bourhis, François Janot
BACKGROUND: A previous randomized trial in recurrent Head and Neck squamous-cell carcinoma (HNSCC) has shown re-irradiation combined with chemotherapy after salvage surgery significantly improved disease-free survival (DFS). The objective of this randomized trial was to compare two methods of re-irradiation in terms of toxicity and survival. PATIENTS AND METHODS: Patients with recurrence/second primary in previously irradiated area were randomly allocated to receive either 60 Gy over 11 weeks with concomitant 5FU - hydroxyurea (VP-arm), or 60 Gy (1...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29778640/work-factors-associated-with-return-to-work-in-out-of-hospital-cardiac-arrest-survivors
#11
Alexis Descatha, Florence Dumas, Wulfran Bougouin, Alain Cariou, Guillaume Geri
INTRODUCTION: Although the survival rate after out-of-hospital cardiac arrest (OHCA) has increased over time, little is known about the return to work of OHCA survivors. We aim to evaluate prevalence and factors associated with return to work (RTW) in OHCA survivors. PATIENTS AND METHODS: All consecutive OHCA survivors aged 18-65 years and discharged alive from a Paris tertiary intensive care unit between 2000 and 2013 were included. Pre-hospital care, in-hospital care, and after-hospital discharge data, such as work description (work location, job classification, nature of the job) were compared relative to work status and RTW...
May 17, 2018: Resuscitation
https://www.readbyqxmd.com/read/29778545/a-descriptive-model-for-a-multidisciplinary-unit-for-colorectal-and-pelvic-malformations
#12
Alejandra Vilanova-Sanchez, Devin R Halleran, Carlos A Reck-Burneo, Alessandra C Gasior, Laura Weaver, Meghan Fisher, Andrea Wagner, Onnalisa Nash, Kristina Booth, Kaleigh Peters, Charae Williams, Sarah Mayer Brown, Peter Lu, Molly Fuchs, Karen Diefenbach, Jeffrey R Leonard, Geri Hewitt, Kate McCracken, Carlo Di Lorenzo, Richard J Wood, Marc A Levitt
INTRODUCTION: Patients with anorectal malformations (ARM), Hirschsprung disease (HD), and colonic motility disorders often require care from specialists across a variety of fields, including colorectal surgery, urology, gynecology, and GI motility. We sought to describe the process of creating a collaborative process for the care of these complex patients. METHODS: We developed a model of a devoted center for these conditions that includes physicians, psychologists, social workers, nurses, and advanced practice nurses...
April 19, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29771612/state-indoor-tanning-laws-and-prevalence-of-indoor-tanning-among-us-high-school-students-2009-2015
#13
Jin Qin, Dawn M Holman, Sherry Everett Jones, Zahava Berkowitz, Gery P Guy
OBJECTIVES: To examine the association between state indoor tanning laws and indoor tanning behavior using nationally representative samples of US high school students younger than 18 years. METHODS: We combined data from the 2009, 2011, 2013, and 2015 national Youth Risk Behavior Surveys (n = 41 313) to analyze the association between 2 types of state indoor tanning laws (age restriction and parental permission) and the prevalence of indoor tanning during the 12 months before the survey, adjusting for age, race/ethnicity, and survey year, and stratified by gender...
May 17, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29759832/safety-and-efficacy-of-multipoint-pacing-in-cardiac-resynchronization-therapy-the-multipoint-pacing-trial
#14
Imran Niazi, James Baker, Raffaele Corbisiero, Charles Love, David Martin, Robert Sheppard, Seth J Worley, Niraj Varma, Kwangdeok Lee, Gery Tomassoni
OBJECTIVES: The MultiPoint Pacing (MPP) trial assessed the safety and efficacy of pacing 2 left ventricular sites with a quadripolar lead in patients with heart failure indicated for a CRT-D device. BACKGROUND: Cardiac resynchronization therapy nonresponse is a complex problem where stimulation of multiple left ventricular sites may be a solution. METHODS: Enrolled patients were indicated for a CRT-D system. Bi-ventricular (Bi-V) pacing was activated at implant...
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29754812/a-randomized-controlled-trial-to-evaluate-the-safety-and-efficacy-of-cardiac-contractility-modulation
#15
William T Abraham, Karl-Heinz Kuck, Rochelle L Goldsmith, JoAnn Lindenfeld, Vivek Y Reddy, Peter E Carson, Douglas L Mann, Benjamin Saville, Helen Parise, Rodrigo Chan, Phi Wiegn, Jeffrey L Hastings, Andrew J Kaplan, Frank Edelmann, Lars Luthje, Rami Kahwash, Gery F Tomassoni, David D Gutterman, Angela Stagg, Daniel Burkhoff, Gerd Hasenfuß
OBJECTIVES: The authors sought to confirm a subgroup analysis of the prior FIX-HF-5 (Evaluate Safety and Efficacy of the OPTIMIZER System in Subjects With Moderate-to-Severe Heart Failure) study showing that cardiac contractility modulation (CCM) improved exercise tolerance (ET) and quality of life in patients with ejection fractions between 25% and 45%. BACKGROUND: CCM therapy for New York Heart Association (NYHA) functional class III and IV heart failure (HF) patients consists of nonexcitatory electrical signals delivered to the heart during the absolute refractory period...
May 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29748377/galectin-3-modulates-the-polarized-surface-delivery-of-%C3%AE-1-integrin-in-epithelial-cells
#16
Ellena Hönig, Karina Ringer, Jenny Dewes, Tobias von Mach, Natalia Kamm, Geri Kreitzer, Ralf Jacob
Epithelial cells require a precise intracellular transport and sorting machinery in order to establish and maintain their polarized architecture. This machinery includes beta-galactoside binding galectins for glycoprotein targeting to the apical membrane. Galectin-3 sorts cargo destined for the apical plasma membrane into vesicular carriers. After delivery of cargo to the apical milieu, galectin-3 recycles back into sorting organelles. We analyzed the role of galectin-3 in the polarized distribution of β1-integrin in MDCK cells...
May 10, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29742613/perceptual-and-structural-facilitators-and-barriers-to-becoming-a-surgeon-a-qualitative-study-of-african-american-and-latino-surgeons
#17
Jesus G Ulloa, Omar Viramontes, Gery Ryan, Kenneth Wells, Melinda Maggard-Gibbons, Gerardo Moreno
PURPOSE: As racial and ethnic heterogeneity in the U.S. population increases, it is important that the health care workforce, including surgery, mirror that diversity. Structural and perceptual barriers may contribute to an underrepresentation of African-American and Latino surgeons. Understanding these barriers may translate into interventions, and in turn, improved diversification of the U.S. surgery workforce. METHOD: In 2016, the authors conducted in-depth semistructured interviews to explore structural and perceptual barriers African-American and Latino surgeons face...
May 8, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29740804/colorectal-cancer-screening-preferences-past-behavior-and-future-intentions
#18
Carol Mansfield, Donatus U Ekwueme, Florence K L Tangka, Derek S Brown, Judith Lee Smith, Gery P Guy, Chunyu Li, Brett Hauber
BACKGROUND: Screening rates for colorectal cancer are below the Healthy People 2020 goal. There are several colorectal cancer screening tests that differ in terms of accuracy, recommended frequency, and administration. In this article, we compare how a set of personal characteristics correlates with preferences for colorectal cancer screening test attributes, past colorectal cancer screening behavior, and future colorectal cancer screening intentions. METHODS: We conducted a discrete-choice experiment survey to assess relative preferences for attributes of colorectal cancer screening tests among adults aged 50-75 years in USA...
May 9, 2018: Patient
https://www.readbyqxmd.com/read/29740777/severe-metabolic-acidosis-after-out-of-hospital-cardiac-arrest-risk-factors-and-association-with-outcome
#19
Matthieu Jamme, Omar Ben Hadj Salem, Lucie Guillemet, Pierre Dupland, Wulfran Bougouin, Julien Charpentier, Jean-Paul Mira, Frédéric Pène, Florence Dumas, Alain Cariou, Guillaume Geri
BACKGROUND: Metabolic acidosis is frequently observed as a consequence of global ischemia-reperfusion after out-of-hospital cardiac arrest (OHCA). We aimed to identify risk factors and assess the impact of metabolic acidosis on outcome after OHCA. METHODS: We included all consecutive OHCA patients admitted between 2007 and 2012. Using admission data, metabolic acidosis was defined by a positive base deficit and was categorized by quartiles. Main outcome was survival at ICU discharge...
May 8, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29740386/effectiveness-of-trigger-point-manual-treatment-on-the-frequency-intensity-and-duration-of-attacks-in-primary-headaches-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Luca Falsiroli Maistrello, Tommaso Geri, Silvia Gianola, Martina Zaninetti, Marco Testa
Background: A variety of interventions has been proposed for symptomatology relief in primary headaches. Among these, manual trigger points (TrPs) treatment gains popularity, but its effects have not been investigated yet. Objective: The aim was to establish the effectiveness of manual TrP compared to minimal active or no active interventions in terms of frequency, intensity, and duration of attacks in adult people with primary headaches. Methods: We searched MEDLINE, COCHRANE, Web Of Science, and PEDro databases up to November 2017 for randomized controlled trials (RCTs)...
2018: Frontiers in Neurology
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