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https://www.readbyqxmd.com/read/29041982/costs-related-to-cardiac-arrest-management-a-systematic-review-protocol
#1
Guillaume Geri, Joshua Gilgan, Carolyn Ziegler, Wanrudee Isaranuwatchai, Laurie J Morrison
BACKGROUND: Each year, about 500,000 people suffer a cardiac arrest (either out-of-hospital or in-hospital) in the USA. Although significant improvements in survival have occurred through the implementation of complex high-quality protocols of care, global costs related to such management are not clearly described. METHODS: We will undertake a systematic review of the published literature on costs related to the acute phase of cardiac arrest management (from collapse to hospital discharge)...
October 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28987025/an-integrated-bioprocess-for-the-expansion-and-chondrogenic-priming-of-human-periosteum-derived-progenitor-cells-in-suspension-bioreactors
#2
Priyanka Gupta, Liesbet Geris, Frank P Luyten, Ioannis Papantoniou
The increasing use of microcarrier based suspension bioreactors for scalable expansion of adult progenitor cells in recent years reveals the necessity of such approaches to address bio manufacturing challenges of advanced therapeutic medicinal products. However, the differentiation of progenitor cells within suspension bioreactors for the production of tissue modules is of equal importance but not well investigated. This study reports on the development of a bioreactor based integrated process for expansion and chondrogenic priming of human periosteum derived stem cells (hPDCs) using Cultispher S microcarriers...
October 7, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28977228/cross-cultural-adaptation-and-validation-of-the-moral-distress-scale-revised-for-nurses
#3
Aline Marcelino Ramos, Edison Luiz Devos Barlem, Jamila Geri Tomaschewski Barlem, Laurelize Pereira Rocha, Graziele de Lima Dalmolin, Aline Belletti Figueira
Objective: Cross-culturally adapt and validate the Moral Distress Scale-Revised for nurses. Method: Quantitative, analytical cross-sectional study conducted with 157 nurses of two hospital institutions of Southern Brazil, one public and one philanthropic. Procedures conducted: cultural adaptation of the instrument according to international recommendations; validation for the Brazilian context. Results: Face and content validation was considered satisfactory as assessed by a specialist committee and a pretest...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28975295/contribution-of-opioid-involved-poisoning-to-the-change-in-life-expectancy-in-the-united-states-2000-2015
#4
Deborah Dowell, Elizabeth Arias, Kenneth Kochanek, Robert Anderson, Gery P Guy, Jan L Losby, Grant Baldwin
No abstract text is available yet for this article.
September 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28969101/correction-inhibition-of-ire1%C3%AE-driven-pro-survival-pathways-is-a-promising-therapeutic-application-in-acute-myeloid-leukemia
#5
Haibo Sun, De-Chen Lin, Xiao Guo, Behzad Kharabi Masouleh, Sigal Gery, Qi Cao, Serhan Alkan, Takayuki Ikezoe, Chie Akiba, Ronald Paquette, Wenwen Chien, Carsten Müller-Tidow, Yang Jing, Konstantin Agelopoulos, Markus Müschen, H Phillip Koeffler
[This corrects the article DOI: 10.18632/oncotarget.7702.].
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28949292/mechanism-of-environmentally-driven-conformational-changes-that-modulate-h-ns-dna-bridging-activity
#6
Ramon A van der Valk, Jocelyne Vreede, Liang Qin, Geri F Moolenaar, Andreas Hofmann, Nora Goosen, Remus T Dame
Bacteria frequently need to adapt to altered environmental conditions. Adaptation requires changes in gene expression, often mediated by global regulators of transcription. The nucleoid-associated protein H-NS is a key global regulator in Gram-negative bacteria and is believed to be a crucial player in bacterial chromatin organization via its DNA-bridging activity. H-NS activity in vivo is modulated by physico-chemical factors (osmolarity, pH, temperature) and interaction partners. Mechanistically, it is unclear how functional modulation of H-NS by such factors is achieved...
September 26, 2017: ELife
https://www.readbyqxmd.com/read/28914161/a-net-of-friends-investigating-friendship-by-integrating-attachment-theory-and-social-network-analysis
#7
Omri Gillath, Gery C Karantzas, Emre Selcuk
The current article focuses on attachment style-an individual difference widely studied in the field of close relationships-and its application to the study of social networks. Specifically, we investigated whether attachment style predicts perception and management of social networks. In Study 1, we examined the associations of attachment style with perceptions of network tie strength and multiplexity. In Studies 2a and 2b, we investigated the association between attachment style and network management skills (initiating, maintaining, and dissolving ties) and whether network management skills mediated the associations of attachment style with network tie strength and multiplexity...
July 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28904384/targeting-the-vulnerability-to-nad-depletion-in-b-cell-acute-lymphoblastic-leukemia
#8
S Takao, W Chien, V Madan, D-C Lin, L-W Ding, Q-Y Sun, A Mayakonda, M Sudo, L Xu, Y Chen, Y-Y Jiang, S Gery, M Lill, E Park, W Senapedis, E Baloglu, M Müschen, H P Koeffler
Although substantial progress has been made in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), the prognosis of patients with either refractory or relapsed B-ALL remains dismal. Novel therapeutic strategies are needed to improve the outcome of these patients. KPT-9274 is a novel dual inhibitor of p21-activated kinase 4 (PAK4) and nicotinamide phosphoribosyltransferase (NAMPT). PAK4 is a serine/threonine kinase that regulates a variety of fundamental cellular processes. NAMPT is a rate-limiting enzyme in the salvage biosynthesis pathway of nicotinamide adenine dinucleotide (NAD) that plays a vital role in energy metabolism...
September 14, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28881568/modulation-of-estrogen-related-receptor-alpha-activity-by-the-kinesin-kif17
#9
Am Pramodh Bandara Seneviratne, Zeynep Turan, Aurelie Hermant, Patrick Lecine, William O Smith, Jean-Paul Borg, Fanny Jaulin, Geri Kreitzer
Estrogen-related receptor alpha (ERR1) is an orphan nuclear receptor that can bind transcriptional co-activators constitutively. ERR1 expression correlates with poor patient outcomes in breast cancer, heightening interest in this nuclear receptor as a therapeutic target. Because ERR1 has no known regulatory ligand, a major challenge in targeting its activity is to find cellular or synthetic modulators of its function. We identified an interaction between ERR1 and KIF17, a kinesin-2 family microtubule motor, in a yeast-2-hybrid screen...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28873062/a-prospective-randomized-controlled-clinical-trial-to-assess-use-of-2-lidocaine-irrigation-to-prevent-abdominal-surgical-site-infection
#10
Alejandro Quiroga-Garza, Juan Manuel Valdivia-Balderas, Miguel Ángel Trejo-Sánchez, Abraham Guadalupe Espinosa-Uribe, Cynthia Guadalupe Reyes-Hernández, Rodrigo Enrique Elizondo-Omaña
Surgical site infections (SSI) are the third most common nosocomial infection, increasing morbidity and mortality rates of patients as well as their costs of care, but longer-term follow up studies and data are limited. Lidocaine, in addition to being a readily available and accessible local anesthetic, is known to have bacteriostatic properties. A prospective, descriptive, controlled, randomized clinical trial was conducted among patients scheduled to undergo abdominal sur- gery in the general surgical unit of a Mexican hospital...
August 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28870520/loss-of-nrf2-promotes-alveolar-type-2-cell-loss-in-irradiated-fibrotic-lung
#11
Geri Traver, Stacey Mont, David Gius, William E Lawson, George X Ding, Konjeti R Sekhar, Michael L Freeman
The development of radiation-induced pulmonary fibrosis represents a critical clinical issue limiting delivery of therapeutic doses of radiation to non-small cell lung cancer. Identification of the cell types whose injury initiates a fibrotic response and the underlying biological factors that govern that response are needed for developing strategies that prevent or mitigate fibrosis. C57BL/6 mice (wild type, Nrf2 null, Nrf2(flox/flox), and Nrf2(Δ/Δ); SPC-Cre) were administered a thoracic dose of 12Gy and allowed to recover for 250 days...
November 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28852970/exploring-barriers-to-the-receipt-of-necessary-medical-care-among-cancer-survivors-under-age-65%C3%A2-years
#12
Matthew P Banegas, John F Dickerson, Erin E Kent, Janet S de Moor, Katherine S Virgo, Gery P Guy, Donatus U Ekwueme, Zhiyuan Zheng, Stephanie Nutt, Loyce Pace, Alexandra Varga, Lisa Waiwaiole, Jennifer Schneider, K Robin Yabroff
PURPOSE: With increasing cancer care costs and greater patient cost-sharing in the USA, understanding access to medical care among cancer survivors is imperative. This study aims to identify financial, psychosocial, and cancer-related barriers to the receipt of medical care, tests, or treatments deemed necessary by the doctor or patient for cancer among cancer survivors age < 65 years. METHODS: We used data on 4321 cancer survivors aged 18-64 years who completed the 2012 LIVESTRONG Survey...
August 29, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28843399/valosin-containing-protein-p97-as-a-novel-therapeutic-target-in-acute-lymphoblastic-leukemia
#13
Gabriele Gugliotta, Makoto Sudo, Qi Cao, De-Chen Lin, Haibo Sun, Sumiko Takao, Ronan Le Moigne, Mark Rolfe, Sigal Gery, Markus Müschen, Michele Cavo, H Phillip Koeffler
B acute lymphoblastic leukemia (B-ALL) cells are distinctively vulnerable to endoplasmic reticulum (ER) stress. Recently, inhibition of p97 was shown to induce ER stress and subsequently cell death in solid tumors and in multiple myeloma. We investigated the role of a novel, orally available, p97 inhibitor (CB-5083; Cleave Biosciences) in B-ALL. CB-5083 induced a significant reduction in viability in 10 human B-ALL cell lines, harboring the most common fusion-genes involved in pediatric and adult B-ALL, with IC50s ranging from 0...
October 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28818245/estimation-of-breast-cancer-incident-cases-and-medical-care-costs-attributable-to-alcohol-consumption-among-insured-women-aged-45-years-in-the-u-s
#14
Donatus U Ekwueme, Benjamin T Allaire, William J Parish, Cheryll C Thomas, Diana Poehler, Gery P Guy, Arnie P Aldridge, Sejal R Lahoti, Temeika L Fairley, Justin G Trogdon
INTRODUCTION: This study estimated the percentage of breast cancer cases, total number of incident cases, and total annual medical care costs attributable to alcohol consumption among insured younger women (aged 18-44 years) by type of insurance and stage at diagnosis. METHODS: The study used the 2012-2013 National Survey on Drug Use and Health, cancer incidence data from two national registry programs, and published relative risk measures to estimate the: (1) alcohol-attributable fraction of breast cancer cases among younger women by insurance type; (2) total number of breast cancer incident cases attributable to alcohol consumption by stage at diagnosis and insurance type among younger women; and (3) total annual medical care costs of treating breast cancer incident cases attributable to alcohol consumption among younger women...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28813304/editorial-overview-contemporary-insights-into-the-relationships-and-stress-nexus-contexts-processes-and-outcomes
#15
EDITORIAL
Gery C Karantzas, Jeffry A Simpson, Marita P McCabe
No abstract text is available yet for this article.
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813299/stress-and-wellbeing-during-chronic-illness-and-partner-death-in-later-life-the-role-of-social-support
#16
REVIEW
Gery C Karantzas, Omri Gillath
Chronic illness and the death of a romantic partner are two of the most significant stressors reported by older adults, resulting in various physical and mental health consequences. Evidence suggests that social support is a key factor in understanding the association between chronic illness and widowhood and the wellbeing of older adults. Nevertheless, research into social support is often approached in an atheoretical manner when investigating these stressors in older adulthood. We attempt to address this theoretical chasm by proposing an integrative model to explain social support processes in older couples which draws on models of social support and attachment theory...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813296/couple-conflict-insights-from-an-attachment-perspective
#17
REVIEW
Judith A Feeney, Gery C Karantzas
The experience of conflict is often cited as a highly stressful relational phenomenon by romantic couples, and can have negative implications for relationship satisfaction and for the longevity of romantic relationships. In this paper, we review extant research on couple conflict in romantic relationships from an attachment theory perspective. The research we review is underpinned by two central tenets: firstly, severe or persistent conflict activates the attachment system; secondly, responses to couple conflict involve complex attachment dynamics, shaped by partners' attachment anxiety and avoidance...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28797517/gynecologic-anatomic-abnormalities-following-anorectal-malformations-repair
#18
Alejandra Vilanova-Sanchez, Carlos A Reck, Kate A McCracken, Victoria A Lane, Alessandra C Gasior, Richard J Wood, Marc A Levitt, Geri D Hewitt
BACKGROUND/AIM: Patients may present with gynecologic concerns after previous posterior sagittal anorectoplasty (PSARP) for repair of an anorectal malformation (ARM). Common findings include an inadequate or shortened perineal body, as well as introital stenosis, retained vaginal septum, and remnant rectovestibular fistula. An inadequate or shortened perineal body may impact fecal continence, sexual function and recommendations regarding obstetrical mode of delivery. We describe our experience with female patients referred to our center for evaluation of their previously repaired ARM, with a specific focus on perineal body anatomy and concomitant gynecologic abnormalities...
July 24, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28765503/advance-directives-hospitalization-and-survival-among-advanced-cancer-patients-with-delirium-presenting-to-the-emergency-department-a-prospective-study
#19
Ahmed F Elsayem, Eduardo Bruera, Alan Valentine, Carla L Warneke, Geri L Wood, Sai-Ching J Yeung, Valda D Page, Julio Silvestre, Patricia A Brock, Knox H Todd
BACKGROUND: To improve the management of advanced cancer patients with delirium in an emergency department (ED) setting, we compared outcomes between patients with delirium positively diagnosed by both the Confusion Assessment Method (CAM) and Memorial Delirium Assessment Scale (MDAS), or group A (n = 22); by the MDAS only, or group B (n = 22); and by neither CAM nor MDAS, or group C (n = 199). MATERIALS AND METHODS: In an oncologic ED, we assessed 243 randomly selected advanced cancer patients for delirium using the CAM and the MDAS and for presence of advance directives...
August 1, 2017: Oncologist
https://www.readbyqxmd.com/read/28753199/erratum-capturing-the-wide-variety-of-impaired-fracture-healing-phenotypes-in-neurofibromatosis-type-1-with-eight-key-factors-a-computational-study
#20
A Carlier, H Brems, J M A Ashbourn, I Nica, E Legius, L Geris
This corrects the article DOI: 10.1038/srep20010.
June 30, 2017: Scientific Reports
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