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https://www.readbyqxmd.com/read/27936486/microrna-4656-is-a-prognostic-factor-and-tumor-suppressor-in-human-pancreatic-through-downstream-tareget-of-trka
#1
Xianglong Tan, Jinyong Lv, Guodong Zhao, Zhiming Zhao, Chenggang Li, Yong Xu, Minggen Hu
BACKGROUND: In this study, we investigated the expression profile and functional mechanism of microRNA-4656 in human pancreatic cancer (PC). METHODS: MiR-4656 expression in PC tumors was examined by qRT-PCR in 134 patients. Associations between tumorous miR-4656 expression and patient's clinicopathological parameters and overall survival were analyzed. MiR-4656 expression was also examined in PC in vitro cell lines. In Capan-1 and AsPC-1 PC cells, lentivirus-induced miR-4656 overexpression or downregulation was applied to investigate its functional regulations on PC in vitro proliferation and invasion, and in vivo transplant growth...
December 9, 2016: Journal of Gene Medicine
https://www.readbyqxmd.com/read/27936456/1%C3%AE-25-dihydroxyvitamin-d-inhibits-de-novo-fatty-acid-synthesis-and-lipid-accumulation-in-metastatic-breast-cancer-cells-through-down-regulation-of-pyruvate-carboxylase
#2
Tomasz Wilmanski, Kimberly Buhman, Shawn S Donkin, John R Burgess, Dorothy Teegarden
Both increased de novo fatty acid synthesis and higher neutral lipid accumulation are a common phenotype observed in aggressive breast cancer cells, making lipid metabolism a promising target for breast cancer prevention. In the present studies, we demonstrate a novel effect of the active metabolite of vitamin D, 1α,25-dihydroxyvitamin D (1,25(OH)₂D) on lipid metabolism in malignant breast epithelial cells. Treatment of MCF10CA1a breast epithelial cells with 1,25(OH)₂D (10 nM) for 5 and 7 days decreased the level of triacylglycerol, the most abundant form of neutral lipids, by 20%(±3...
December 1, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27936368/utility-of-brief-versions-of-the-alcohol-use-disorders-identification-test-audit-to-identify-excessive-drinking-among-patients-in-hiv-care-in-south-africa
#3
Neo K Morojele, Sebenzile Nkosi, Connie T Kekwaletswe, Paul A Shuper, Samuel O Manda, Bronwyn Myers, Charles D H Parry
OBJECTIVE: In sub-Saharan Africa, large proportions of patients who are on antiretroviral therapy (ART) engage in excessive alcohol use, which may lead to adverse health consequences and may go undetected. Consequently, health care workers need brief screening tools to be able to routinely identify and manage excessive alcohol use among their patients. Various brief versions of the valid and reliable 10-item Alcohol Use Disorders Identification Test (AUDIT) (i.e., the AUDIT-C, AUDIT-3, AUDIT-QF, AUDIT-PC, AUDIT-4, and m-FAST) may potentially replace the full AUDIT in busy HIV care settings...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936114/long-circulating-curcumin-loaded-liposome-formulations-with-high-incorporation-efficiency-stability-and-anticancer-activity-towards-pancreatic-adenocarcinoma-cell-lines-in-vitro
#4
Mohamed Mahmud, Adriana Piwoni, Nina Filiczak, Martyna Janicka, Jerzy Gubernator
The incorporation of hydrophobic drugs into liposomes improve their bioavailability and leads to increased stability and anticancer activity, along with decreased drug toxicity. Curcumin (Cur) is a natural polyphenol compound with a potent anticancer activity in pancreatic adenocarcinoma (PA). In the present study, different types of Cur-loaded liposomal formulations were prepared and characterized in terms of size, shape, zeta potential, optimal drug-to-lipid ratio and stability at 4°C, 37°C; and in human plasma in vitro...
2016: PloS One
https://www.readbyqxmd.com/read/27935970/sanshool-on-the-fingertip-interferes-with-vibration-detection-in-a-rapidly-adapting-ra-tactile-channel
#5
Scinob Kuroki, Nobuhiro Hagura, Shin'ya Nishida, Patrick Haggard, Junji Watanabe
An Asian spice, Szechuan pepper (sanshool), is well known for the tingling sensation it induces on the mouth and on the lips. Electrophysiological studies have revealed that its active ingredient can induce firing of mechanoreceptor fibres that typically respond to mechanical vibration. Moreover, a human behavioral study has reported that the perceived frequency of sanshool-induced tingling matches with the preferred frequency range of the tactile rapidly adapting (RA) channel, suggesting the contribution of sanshool-induced RA channel firing to its unique perceptual experience...
2016: PloS One
https://www.readbyqxmd.com/read/27935477/regulation-of-b-cell-fate-by-chronic-activity-of-the-ige-b-cell-receptor
#6
Zhiyong Yang, Marcus J Robinson, Xiangjun Chen, Geoffrey Alexander Smith, Jack Taunton, Wanli Liu, Christopher Dc Allen
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE(+) B cells are constrained by chronic activity of the IgE B cell receptor (BCR). In the absence of cognate antigen, the IgE BCR promoted terminal differentiation of B cells into plasma cells (PCs) under cell culture conditions mimicking T cell help. This antigen-independent PC differentiation involved multiple IgE domains and Syk, CD19, BLNK, Btk, and IRF4. Disruption of BCR signaling in mice led to consistently exaggerated IgE(+) germinal center (GC) B cell but variably increased PC responses...
December 9, 2016: ELife
https://www.readbyqxmd.com/read/27935316/rapid-synthesis-of-sub-5-nm-sized-cubic-boron-nitride-nanocrystals-with-high-piezoelectric-behavior-via-electrochemical-shock
#7
Zhigang Chen, Lianhui Li, Shan Cong, Jinnan Xuan, Dengsong Zhang, Fengxia Geng, Ting Zhang, Zhigang Zhao
A key challenge in current superhard materials research is the design of novel superhard nanocrystals (NCs) whereby new and unexpected properties may be predicted. Cubic boron nitride (c-BN) is a superhard material which ranks next to diamond; however, downsizing c-BN material below the 10 nm scale is rather challenging, and the interesting new properties of c-BN NCs remain unexplored and wide open. Herein we report an electrochemical shock method to prepare uniform c-BN NCs with a lateral size of only 3.4 ± 0...
December 9, 2016: Nano Letters
https://www.readbyqxmd.com/read/27935238/identification-of-novel-disulfide-adducts-between-the-thiol-containing-leaving-group-of-the-nerve-agent-vx-and-cysteine-containing-tripeptides-derived-from-human-serum-albumin
#8
Andreas Kranawetvogl, Jim Küppers, Michael Gütschow, Franz Worek, Horst Thiermann, Paul W Elsinghorst, Harald John
Chemical warfare agents represent a continuous and considerable threat to military personnel and the civilian population. Such compounds are prohibited by the Chemical Weapons Convention, to which adherence by the member states is strictly controlled. Therefore, reliable analytical methods for verification of an alleged use of banned substances are required. Accordingly, current research focuses on long-term biomarkers derived from covalent adducts with biomolecules such as proteins. Recently, we have introduced a microbore liquid chromatography/electrospray ionization high-resolution tandem mass spectrometry method allowing for the investigation of two different classes of adducts of the nerve agent VX with human serum albumin (HSA)...
December 9, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27934221/enhancement-of-cell-adhesion-on-a-phosphorylcholine-based-surface-through-the-interaction-with-dna-mediated-by-ca-2-ions
#9
Tomoyuki Azuma, Yuji Teramura, Toru Hoshi, Madoka Takai
2-Methacryloyloxyethyl phosphorylcholine (MPC) has a PC group and is one of the most well-known bioinert polymers. In this study, we evaluated the interaction between MPC and DNA, which specifically interacts with the phospholipid head group via Ca(2+) ions. A MPC monolayer and poly(MPC) brush were fabricated to observe the effect of the structure on the interaction between MPC and DNA via Ca(2+) ions. The poly(MPC) brush, which shows higher MPC unit density, more efficiently interacted with DNA via Ca(2+) ions...
December 8, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27934042/free-excitons-and-exciton-phonon-coupling-in-ch3nh3pbi3-single-crystals-revealed-by-photocurrent-and-photoluminescence-measurements-at-low-temperatures
#10
Le Quang Phuong, Yumi Nakaike, Atsushi Wakamiya, Yoshihiko Kanemitsu
We investigated the exciton-phonon couplings and exciton binding energy in CH3NH3PbI3 (MAPbI3) single crystals using temperature-dependent photocurrent (PC) and photoluminescence (PL) spectroscopy. The PC and PL data provide clear evidence of the existence of excitons in orthorhombic-phase MAPbI3. The temperature-dependent PC data were found to be less influenced by the bound excitons than the PL data, and thus the PC data reflect the intrinsic scatterings of excitons. We observed that the exciton-phonon couplings were strong in MAPbI3 and determined the longitudinal optical phonon energy to be 16...
December 1, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27933925/giant-piezoelectricity-and-high-curie-temperature-in-nanostructured-alkali-niobate-lead-free-piezoceramics-through-phase-coexistence
#11
Bo Wu, Haijun Wu, Jiagang Wu, Dingquan Xiao, Jianguo Zhu, Stephen J Pennycook
Because of growing environmental concerns, the development of lead-free piezoelectric materials with enhanced properties has become of great interest. Here, we report a giant piezoelectric coefficient (d33) of 550 pC/N and a high Curie temperature (TC) of 237 °C in (1-x-y)K1-wNawNb1-zSbzO3-xBiFeO3-yBi0.5Na0.5ZrO3 (KNwNSz-xBF-yBNZ) ceramics by optimizing x, y, z, and w. Atomic-resolution polarization mapping by Z-contrast imaging reveals the intimate coexistence of rhombohedral (R) and tetragonal (T) phases inside nanodomains, that is, a structural origin for the R-T phase boundary in the present KNN system...
November 30, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27933281/pet-imaging-of-urokinase-type-plasminogen-activator-receptor-upar-in-prostate-cancer-current-status-and-future-perspectives
#12
REVIEW
Dorthe Skovgaard, Morten Persson, Andreas Kjaer
Overexpression of urokinase-type plasminogen activator receptors (uPAR) represents an important biomarker for aggressiveness in most common malignant diseases, including prostate cancer (PC). Accordingly, uPAR expression either assessed directly in malignant PC tissue or assessed directly in plasma (intact/cleaved forms)-provides independent additional clinical information to that contributed by PSA, Gleason score, and other relevant pathological and clinical parameters. In this respect, non-invasive molecular imaging by positron emission tomography (PET) offers a very attractive technology platform, which can provide the required quantitative information on the uPAR expression profile, without the need for invasive procedures and the risk of missing the target due to tumor heterogeneity...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27933147/large-scale-implementation-of-a-medicines-reconciliation-care-bundle-in-nhs-ggc-gp-practices
#13
Rachel Bruce
Medicines reconciliation (MR) is an essential process for patient safety, promoting safer use of medicines with effective communication at the interface, particularly when patients are admitted and discharged from hospital. Much of the work on MR has been focussed in secondary care, however, the principles are equally important in primary care. The aim of the work was to test the Scottish Patient Safety in Primary Care (SPSP-PC) MR care bundle and consider scale up and spread across all NHS Greater Glasgow and Clyde (NHS GGC) GP practices...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27932907/optimized-r-functions-for-analysis-of-ecological-community-data-using-the-r-virtual-laboratory-rvlab
#14
Constantinos Varsos, Theodore Patkos, Anastasis Oulas, Christina Pavloudi, Alexandros Gougousis, Umer Zeeshan Ijaz, Irene Filiopoulou, Nikolaos Pattakos, Edward Vanden Berghe, Antonio Fernández-Guerra, Sarah Faulwetter, Eva Chatzinikolaou, Evangelos Pafilis, Chryssoula Bekiari, Martin Doerr, Christos Arvanitidis
BACKGROUND: Parallel data manipulation using R has previously been addressed by members of the R community, however most of these studies produce ad hoc solutions that are not readily available to the average R user. Our targeted users, ranging from the expert ecologist/microbiologists to computational biologists, often experience difficulties in finding optimal ways to exploit the full capacity of their computational resources. In addition, improving performance of commonly used R scripts becomes increasingly difficult especially with large datasets...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27932881/preparation-and-antitumor-evaluation-of-self-assembling-oleanolic-acid-loaded-pluronic-p105-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-mixed-micelles-for-non-small-cell-lung-cancer-treatment
#15
Hao Wu, Qingxiang Zhong, Rongling Zhong, Houcai Huang, Zhi Xia, Zhongcheng Ke, Zhenhai Zhang, Jie Song, Xiaobin Jia
Oleanolic acid (OA) is a triterpenoid found in various fruits and vegetables and used in traditional Chinese medicine. OA plays a crucial role in the treatment of several cancers, but poor water solubility, low permeability, and significant efflux have limited its widespread clinical use. Vitamin E-d-α-tocopheryl polyethylene glycol succinate (vitamin E-TPGS) and Pluronic P105 were used to improve the solubility and permeability and to decrease the efflux of OA. OA-loaded mixed micelles were prepared by ethanol thin-film hydration...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27932557/quantitative-parameters-in-psma-targeted-pet-imaging-with-18f-dcfpyl-variability-in-normal-organ-uptake
#16
Xin Li, Steven P Rowe, Jeffrey P Leal, Michael A Gorin, Mohamad E Allaf, Ashley E Ross, Kenneth J Pienta, Martin A Lodge, Martin G Pomper
PURPOSE: (18)F-DCFPyL is a small-molecule inhibitor of the prostate-specific membrane antigen (PSMA) that has shown promise for evaluation of primary and metastatic prostate cancer (PC) using positron emission tomography (PET). Measuring the variability in normal organ uptake of (18)F-DCFPyL is necessary to understand its biodistribution, aid image interpretation, judge the reliability of scan quantification, and to provide a basis for therapeutic monitoring. METHODS: 65 consecutive (18)F-DCFPyL PET/CT scans from 64 patients with a history of PC were analyzed...
December 8, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27932338/meaning-of-living-with-severe-chronic-obstructive-lung-disease-a-qualitative-study
#17
Gabriella Marx, Maximilian Nasse, Henrikje Stanze, Sonja Owusu Boakye, Friedemann Nauck, Nils Schneider
OBJECTIVES: To explore what it means for patients to live with chronic obstructive pulmonary disease (COPD) as an incurable and constantly progressing disease. DESIGN: Qualitative longitudinal study using narrative and semistructured interviews. This paper presents findings of the initial interviews. Analysis using grounded theory. SETTING: Lung care clinics and community care in Lower Saxony, Germany. PARTICIPANTS: 17 patients with advanced-stage COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) III/IV)...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932267/human-pre-pik3c2b-an-intronic-cis-element-with-dual-function-of-activation-and-repression
#18
Jayant Maini, Mohsen Ghasemi, Deepti Yandhuri, Suman S Thakur, Vani Brahmachari
The Polycomb/Trithorax Responsive Elements (PRE/TREs) are the cis-regulatory sequences that interact with both repressive (PcG) as well as activating (TrxG) complexes. However, most of the mammalian PREs are demonstrated to interact with the repressive polycomb (PcG) complexes only. We have carried out an unbiased search for proteins interacting with human PRE-PIK3C2B (hPRE-PIK3C2B) based on DNA affinity purification followed by mass spectrometry and identified MLL, MLL4 and WDR87 among other proteins in three biological replicates in HEK, U87 and HeLa cell lines...
December 5, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27931835/management-of-patients-with-recurrent-advanced-cervical-cancer-beyond-first-line-platinum-regimens-where-do-we-stand-a-literature-review
#19
REVIEW
Stergios Boussios, Esmeralda Seraj, George Zarkavelis, Dimitrios Petrakis, Aristomenes Kollas, Aikaterini Kafantari, Abraam Assi, Konstantina Tatsi, Nicholas Pavlidis, George Pentheroudakis
BACKGROUND: Cervical cancer is the fourth most common cancer affecting women worldwide. Despite advances in screening and human papillomavirus (HPV) vaccination, a significant number of women present with or develop advanced disease. Palliative platinum-based chemotherapy (CT) is the standard first-line treatment for metastatic/recurrent cervical cancer. The prognosis remains poor and effective second line options are urgently needed. METHODS: We searched the English-language medical literature as well as relevant guideline databases, published from January 1981 to December 2015 and identified publications related to cervical cancer and its therapies...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27930974/mir-200c-enhances-sensitivity-of-drug-resistant-non-small-cell-lung-cancer-to-gefitinib-by-suppression-of-pi3k-akt-signaling-pathway-and-inhibites-cell-migration-via-targeting-zeb1
#20
Guohua Zhou, Fangli Zhang, Yu Guo, Jianfei Huang, Yaqiong Xie, Shuanglei Yue, Minghui Chen, Hao Jiang, Mengjie Li
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is a major obstacle in the treatment of non-small cell lung cancer (NSCLC) patients. We explored the role of miR-200c in modulating the sensitivity of gefitinib-resistant NSCLC cells and examined the underlying mechanism. The gefitinib-resistant cell line PC-9-ZD and its parental PC-9 cells were used. Growth inhibition was detected by MTT assay. The cell apoptosis was detected by Annexin V/PI assay. Cell migration was assessed by wound-healing assay...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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