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https://www.readbyqxmd.com/read/29240175/radiation-induced-birefringence-variations-in-polarization-maintaining-fibers
#1
Yuanhong Yang, Hui Li, Lin Lu, Fuling Yang, Wei Jin
Gamma radiation-induced birefringence (RIB) variations in a solid core photonic crystal polarization-maintaining fiber (Pc-PMF) and a Panda PMF (Pa-PMF) are investigated. Experiments show that the birefringence of the fibers changes approximately linearly with a radiation dose over the range from 0 to 400 krad(Si), with negative slope coefficients of 8.91×10-10/krad(Si) and 4.38×10-9/krad(Si) for the Pc-PMF and Pa-PMF, respectively. Models of RIB variations for the two fibers are established, and the theoretical results agree well with the experimental ones...
December 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29240120/1-7%C3%A2-%C3%A2-%C3%AE-m-band-narrow-linewidth-tunable-raman-fiber-lasers-pumped-by-spectrum-sliced-amplified-spontaneous-emission
#2
Peng Zhang, Di Wu, Quanli Du, Xiaoyan Li, Kexuan Han, Lizhong Zhang, Tianshu Wang, Huilin Jiang
A 1.7 μm band tunable narrow-linewidth Raman fiber laser based on spectrally sliced amplified spontaneous emission (SS-ASE) and multiple filter structures is proposed and experimentally demonstrated. In this scheme, an SS-ASE source is employed as a pump source in order to avoid stimulated Brillouin scattering. The ring configuration includes a 500 m long high nonlinear optical fiber and a 10 km long dispersion shifted fiber as the gain medium. A segment of un-pumped polarization-maintaining erbium-doped fiber is used to modify the shape of the spectrum...
December 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29239677/effects-of-kinect-adventures-games-versus-conventional-physical-therapy-on-postural-control-in-elderly-people-a-randomized-controlled-trial
#3
Jéssica Maria Ribeiro Bacha, Gisele Cristine Vieira Gomes, Tatiana Beline de Freitas, Larissa Alamino Pereira Viveiro, Keyte Guedes da Silva, Géssika Costa Bueno, Eliana Maria Varise, Camila Torriani-Pasin, Angélica Castilho Alonso, Natalia Mariana Silva Luna, Júlia Maria D'Andrea Greve, José Eduardo Pompeu
OBJECTIVE: To compare the effectiveness of Kinect Adventures games versus conventional physiotherapy to improve postural control (PC), gait, cardiorespiratory fitness, and cognition of the elderly. In addition, we evaluated the safety, acceptability, and adherence to the interventions. MATERIALS AND METHODS: The study was a randomized clinical trial in which 46 elderly individuals were selected, mean age 69.3 (5.34) years. Participants were allocated to the Kinect Adventures Training Group (KATG) or the Conventional Physical Therapy Group (CPTG), 23 individuals in each group...
December 14, 2017: Games for Health
https://www.readbyqxmd.com/read/29239410/uptake-and-transcytosis-of-functionalized-superparamagnetic-iron-oxide-nanoparticles-in-an-in-vitro-blood-brain-barrier-model
#4
Angela Ivask, Emily H Pilkington, Thomas Blin, Aleksandr Käkinen, Heiki Vija, Meeri Visnapuu, John F Quinn, Michael R Whittaker, Ruirui Qiao, Thomas P Davis, Pu Chun Ke, Nicolas H Voelcker
Two major hurdles in nanomedicine are the limited strategies for synthesizing stealth nanoparticles and the poor efficacy of the nanoparticles in translocating across the blood brain barrier (BBB). Here we examined the uptake and transcytosis of iron oxide nanoparticles (IONPs) grafted with biomimetic phosphorylcholine (PC) brushes in an in vitro BBB model system, and compared them with bare, PEG or PC-PEG mixture grafted IONPs. Hyperspectral imaging indicated IONP co-localization with cells. Quantitative analysis with total reflection X-ray fluorescence spectrometry showed that after 24 h, 78% of PC grafted, 68-69% of PEG or PC-PEG grafted, and 30% of bare IONPs were taken up by the BBB...
December 14, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29238987/modeling-the-effect-of-platelet-concentrate-supernatants-on-endothelial-cells-focus-on-endocan-esm-1
#5
Sofiane Tariket, Caroline Sut, Charles-Antoine Arthaud, Marie-Ange Eyraud, Astrid Meneveaux, Sandrine Laradi, Hind Hamzeh-Cognasse, Olivier Garraud, Fabrice Cognasse
BACKGROUND: Platelets (PLTs) are prone to activation and the release of biologic response modifiers (BRMs) under storage conditions. The transfusion inflammatory reaction in the vascular compartment involves endothelial cell activation due to cell-cell interactions and BRMs infused with the blood products. Endocan/ESM-1 is a proteoglycan secreted by endothelial cells under the control of proinflammatory cytokines. We aimed to measure endocan activity in supernatants of PLT components (PCs), implicated in serious adverse reactions (SARs) or not (no...
December 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29238922/rational-evaluation-of-the-therapeutic-effect-and-dosimetry-of-auger-electrons-for-radionuclide-therapy-in-a-cell-culture-model
#6
Ayaka Shinohara, Hirofumi Hanaoka, Tetsuya Sakashita, Tatsuhiko Sato, Aiko Yamaguchi, Noriko S Ishioka, Yoshito Tsushima
OBJECTIVE: Radionuclide therapy with low-energy auger electron emitters may provide high antitumor efficacy while keeping the toxicity to normal organs low. Here we evaluated the usefulness of an auger electron emitter and compared it with that of a beta emitter for tumor treatment in in vitro models and conducted a dosimetry simulation using radioiodine-labeled metaiodobenzylguanidine (MIBG) as a model compound. METHODS: We evaluated the cellular uptake of 125I-MIBG and the therapeutic effects of 125I- and 131I-MIBG in 2D and 3D PC-12 cell culture models...
December 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29238517/exogenous-h2s-restores-ischemic-post-conditioning-induced-cardioprotection-through-inhibiting-endoplasmic-reticulum-stress-in-the-aged-cardiomyocytes
#7
Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu, Hongzhu Li, Changqing Xu
Background: A gasotransmitter hydrogen sulfide (H2S) plays an important physiological and pathological role in cardiovascular system. Ischemic post-conditioning (PC) provides cardioprotection in the young hearts but not in the aged hearts. Exogenous H2S restores PC-induced cardioprotection by inhibition of mitochondrial permeability transition pore opening and oxidative stress and increase of autophagy in the aged hearts. However, whether H2S contributes to the recovery of PC-induced cardioprotection via down-regulation of endoplasmic reticulum stress (ERS) in the aged hearts is unclear...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29238219/hypoxia-stress-modifies-na-k-atpase-h-k-atpase-formula-see-text-and-nka%C3%AE-1-isoform-expression-in-the-brain-of-immune-challenged-air-breathing-fish
#8
Mc Subhash Peter, Satheesan Simi
Fishes are equipped to sense stressful stimuli and are able to respond to environmental stressor such as hypoxia with varying pattern of stress response. The functional attributes of brain to hypoxia stress in relation to ion transport and its interaction during immune challenge have not yet delineated in fish. We, therefore, explored the pattern of ion transporter functions and messenger RNA (mRNA) expression of α1-subunit isoforms of Na+/K+-ATPase (NKA) in the brain segments, namely, prosencephalon (PC), mesencephalon (MC), and metencephalon (MeC) in an obligate air-breathing fish exposed either to hypoxia stress (30 minutes forced immersion in water) or challenged with zymosan treatment (25-200 ng g-1 for 24 hours) or both...
2017: Journal of Experimental Neuroscience
https://www.readbyqxmd.com/read/29238164/a-novel-transdermal-nanoethosomal-gel-of-betahistine-dihydrochloride-for-weight-gain-control-in-vitro-and-in-vivo-characterization
#9
Shahira F El-Menshawe, Adel Ahmed Ali, Abdelkhalk Ali Halawa, Ahmed Sg Srag El-Din
Background: Betahistine dihydrochloride (BDH) is a histamine analog used to control weight gain, with short elimination half-life and gastric irritation as side effects. Objective: The aim of the current investigation is to formulate and optimize a topical BDH ethosomal gel for weight gain control. Materials and methods: Box-Behnken design was applied to study the effect of independent variables: phosphatidylcholine (PC), propylene glycol (PG), and ethanol on vesicle size; entrapment efficiency; % drug release; and flux...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29237504/a-multivariate-analysis-of-calenviroscreen-comparing-environmental-and-socioeconomic-stressors-versus-chronic-disease
#10
Ben K Greenfield, Jayant Rajan, Thomas E McKone
BACKGROUND: The health-risk assessment paradigm is shifting from single stressor evaluation towards cumulative assessments of multiple stressors. Recent efforts to develop broad-scale public health hazard datasets provide an opportunity to develop and evaluate multiple exposure hazards in combination. METHODS: We performed a multivariate study of the spatial relationship between 12 indicators of environmental hazard, 5 indicators of socioeconomic hardship, and 3 health outcomes...
December 13, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29236328/mirnalet-7a-mediates-prostate-cancer-pc-3-cell-invasion-migration-by-inducing-epithelial-mesenchymal-transition-through-ccr7-mapk-pathway
#11
Tang Guanlin, Du Ruoyang, Tang Zhaobing, Kuang Youlin
Prostate cancer is one of the most common malignancies in older men. Recent evidence has demonstrated microRNA (miRNA) Let-7a expression decreased in prostate cancer, while the expression of C-C chemokine receptor type 7 (CCR7) increased. In this study, we investigated whether CCR7 overexpression was associated with a decrease in the expression of miRNA let-7a in invasion and metastasis of prostate cancer cell. Methods Synthetic let-7a mimics and let-7a inhibitors were transfected into prostate cancer PC-3 cells repectively...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29234928/alterations-in-acetylcholinesterase-and-butyrylcholinesterase-activities-in-chronic-obstructive-pulmonary-disease-relationships-with-oxidative-and-inflammatory-markers
#12
Amel Ben Anes, Hela Ben Nasr, Abdelhamid Garrouch, Sarra Bennour, Sarra Bchir, Mohamed Hachana, Mohamed Benzarti, Zouhair Tabka, Karim Chahed
This work focused on finding a relationship between acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities and the development and severity of COPD. The possible link of these enzymes to oxidative and inflammatory processes was also investigated. The study included 229 healthy controls and 153 COPD patients. Erythrocyte AChE and plasma BChE activities were determined using spectrophotometric methods. Markers related to the oxidative status including thiobarbituric acid-reactive substances (TBARS), total protein carbonyls (PCs), advanced oxidation protein products (AOPP), reduced glutathione, nitric oxide, and peroxynitrite were measured...
December 12, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29234623/are-perinatal-events-risk-factors-for-childhood-thyroid-autoimmunity
#13
Berglind Jonsdottir, Markus Lundgren, Sara Wallengren, Åke Lernmark, Ida Jönsson, Helena Elding Larsson
Background: Environmental and genetic factors possibly trigger thyroid autoimmunity. Studies on perinatal risk factors for childhood thyroid autoimmunity are sparse. Objectives: The aim was to investigate if perinatal factors, family history of autoimmune diseases, and HLA-DQ genotypes contribute to thyroid autoimmunity in the Diabetes Prediction in Skåne (DiPiS) study. Methods: Samples from 1,874 ten-year-old children were analyzed for autoantibodies to thyroid peroxidase (TPOAb), thyroglobulin (TGAb), and HLA-DQ genotypes...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234427/a-chinese-herbal-formula-gengnianchun-ameliorates-%C3%AE-amyloid-peptide-toxicity-in-a-caenorhabditis-elegans-model-of-alzheimer-s-disease
#14
Fanhui Meng, Jun Li, Yanqiu Rao, Wenjun Wang, Yan Fu
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, and the few drugs that are currently available only treat the symptoms. Traditional medicine or phytotherapy has been shown to protect against AD. In our previous studies, Gengnianchun (GNC), a traditional Chinese medicine formula with a prolongevity effect, protected against Aβ-induced cytotoxicity in pheochromocytoma cells (PC-12 cells) and hippocampal cells. Here, we investigated the effects and possible mechanisms by which GNC protected against Aβ toxicity using transgenic Caenorhabditis elegans CL4176...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234291/the-role-of-baseline-vagal-tone-in-dealing-with-a-stressor-during-face-to-face-and-computer-based-social-interactions
#15
Daniele Rigoni, Francesca Morganti, Paride Braibanti
Facing a stressor involves a cardiac vagal tone response and a feedback effect produced by social interaction in visceral regulation. This study evaluated the contribution of baseline vagal tone and of social engagement system (SES) functioning on the ability to deal with a stressor. Participants (n = 70) were grouped into a minimized social interaction condition (procedure administered through a PC) and a social interaction condition (procedure administered by an experimenter). The State Trait Anxiety Inventory, the Social Interaction Anxiety Scale, the Emotion Regulation Questionnaire and a debriefing questionnaire were completed by the subjects...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29234196/glycochenodeoxycholic-acid-does-not-increase-transforming-growth-factor-beta-expression-in-bile-duct-epithelial-cells-or-collagen-synthesis-in-myofibroblasts
#16
Anna Wang, Dorothy Yu, Yuewen Gong, Jessie Garber, Gerald Y Minuk
Background/Aims: Primary sclerosing cholangitis (PSC) is a chronic, progressive hepatobiliary disorder characterized by extensive fibrosis and stricturing of the intra- and/or extra-hepatic bile ducts: Previous studies have documented low phosphatylcholine (PC) concentrations in PSC bile. The aim of this study was to determine whether low PC levels in bile facilitate toxic bile acid induced injury of biliary tract epithelial cells resulting in enhanced transforming growth factor-beta (TGF-β) expression and increased collagen synthesis by myofibroblasts...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234063/the-sam-sam-interaction-between-ship2-and-the-epha2-receptor-design-and-analysis-of-peptide-inhibitors
#17
Flavia Anna Mercurio, Concetta Di Natale, Luciano Pirone, Roberta Iannitti, Daniela Marasco, Emilia Maria Pedone, Rosanna Palumbo, Marilisa Leone
The lipid phosphatase Ship2 represents a drug discovery target for the treatment of different diseases, including cancer. Its C-terminal sterile alpha motif domain (Ship2-Sam) associates with the Sam domain from the EphA2 receptor (EphA2-Sam). This interaction is expected to mainly induce pro-oncogenic effects in cells therefore, inhibition of the Ship2-Sam/EphA2-Sam complex may represent an innovative route to discover anti-cancer therapeutics. In the present work, we designed and analyzed several peptide sequences encompassing the interaction interface of EphA2-Sam for Ship2-Sam...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233248/results-of-amhp-journal-survey-on-open-access
#18
Pamela C Day
Day PC. Results of AMHP journal survey on Open Access. Aerospace Med Hum Perform. 2018; 89(1):70-71.
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29233228/disease-and-non-battle-traumatic-injuries-evaluated-by-emergency-physicians-in-a-us-tertiary-combat-hospital
#19
Col S Vikhyat S Bebarta, Alejandra G Mora, Capt Patrick C Ng, Phillip E Mason, Andrew Muck, Maj Joseph K Maddry
Introduction Analysis of injuries during military operations has focused on those related to combat. Non-combat complaints have received less attention, despite the need for many troops to be evacuated for non-battle illnesses in Iraq. This study aims to further characterize the disease and non-battle injuries (DNBIs) seen at a tertiary combat hospital and to describe the types of procedures and medications used in the management of these cases. METHODS: In this observational study, patients were enrolled from a convenience sample with non-combat-related diseases and injuries who were evaluated in the emergency department (ED) of a US military tertiary hospital in Iraq from 2007-2008...
December 13, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29232134/localisation-of-cholesterol-within-supported-lipid-bilayers-made-of-a-natural-extract-of-tailor-deuterated-phosphatidylcholine
#20
Sarah Waldie, Tania Kjellerup Lind, Kathryn Louise Browning, Martine Moulin, Michael Haertlein, Victor Trevor Forsyth, Alessandra Luchini, Gernot A Strohmeier, Harald Pichler, Selma Maric, Marite Cardenas
Cholesterol is an essential component of mammalian membranes that is known to induce a series of physicochemical changes in the lipid bilayer. Such changes include the formation of liquid ordered phases with an increased thickness and configurational order as compared to liquid disordered phases. For saturated lipid membranes, cholesterol molecules localise close to the lipid head group-tail interface. However, the presence of polyunsaturated lipids was recently shown to promote the relocation of cholesterol towards the inner interface between the two bilayer leaflets...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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