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https://www.readbyqxmd.com/read/29046044/lipidomics-profiling-reveals-the-role-of-glycerophospholipid-metabolism-in-psoriasis
#1
Chunwei Zeng, Bo Wen, Guixue Hou, Li Lei, Zhanlong Mei, Xuekun Jia, Xiaomin Chen, Wu Zhu, Jie Li, Yehong Kuang, Weiqi Zeng, Juan Su, Siqi Liu, Cong Peng, Xiang Chen
Psoriasis is a common and chronic inflammatory skin disease that is complicated by gene-environment interactions. Although genomic, transcriptomic, and proteomic analyses have been performed to investigate the pathogenesis of psoriasis, the role of metabolites in psoriasis, particularly of lipids, remains unclear. Lipids not only comprise the bulk of the cellular membrane bilayers but also regulate a variety of biological processes such as cell proliferation, apoptosis, immunity, angiogenesis, and inflammation...
October 1, 2017: GigaScience
https://www.readbyqxmd.com/read/29045559/segregated-excitatory-inhibitory-recurrent-subnetworks-in-layer-5-of-the-rat-frontal-cortex
#2
Mieko Morishima, Kenta Kobayashi, Shigeki Kato, Kazuto Kobayashi, Yasuo Kawaguchi
A prominent feature of neocortical pyramidal cells (PCs) is their numerous projections to diverse brain areas. In layer 5 (L5) of the rat frontal cortex, there are 2 major subtypes of PCs that differ in their long-range axonal projections, corticopontine (CPn) cells and crossed corticostriatal (CCS) cells. The outputs of these L5 PCs can be regulated by feedback inhibition from neighboring cortical GABAergic cells. Two major subtypes of GABAergic cells are parvalbumin (PV)-positive and somatostatin (SOM)-positive cells...
October 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29045272/palliative-nursing-for-cancer-patients-as-an-abstract-concept-a-hermeneutic-study
#3
Leili Borimnejad, Marjan Mardani-Hamooleh, Naimeh Seyedfatemi, Mamak Tahmasebi
BACKGROUND: Understanding the outcomes of palliative care (PC) that is provided to patients with cancer is necessary. PURPOSE: The aim of this study was to explore the lived experiences of Iranian nurses with regard to PC outcomes in cancer patients. METHODS: This hermeneutic study interviewed 14 nurses to understand their lived experiences with regard to PC outcomes in cancer patients. A seven-stage process of data analysis was employed. RESULTS: One constitutive pattern "palliative nursing for cancer patients is an abstractive concept" and the two associated themes of "providing excellent PC" and "PC as an alarm" were identified...
October 18, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29045127/revealing-dynamics-of-accumulation-of-systemically-injected-liposomes-in-the-skin-by-intravital-microscopy
#4
James I Griffin, Guankui Wang, Weston J Smith, Vivian P Vu, Robert Scheinman, Dominik Stitch, Radu Moldovan, Seyed Moein Moghimi, Dmitri Simberg
Accumulation of intravenously injected cytotoxic liposomes in the skin induces serious toxicity. We used single time point and longitudinal intravital microscopy to understand skin accumulation dynamics of non-PEGylated and PEGylated liposomes after systemic injection into mice. Non-PEGylated egg phosphatidylcholine (PC) liposomes showed short circulation half-life (1.3 h) and immediate aggregation in the blood, with some aggregates lodging in skin microvasculature soon after the injection. At 24 h, and more prominently at 48 h postinjection, liposomes appeared in dermal and subdermal cells...
October 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/29045005/natural-antibodies-to-oxidation-specific-epitopes-innate-immune-response-and-venous-thromboembolic-disease
#5
S Eichinger, P A Kyrle, M Kammer, L Eischer, M Ozsvar Kozma, C J Binder
BACKGROUND AND OBJECTIVES: Natural antibodies to oxidation-specific epitopes protect from atherothrombotic events. Whether mechanisms of innate immunity are relevant in the pathogenesis of venous thromboembolism (VTE) is unknown. PATIENTS/METHODS: We measured plasma levels of IgM antibodies to oxidized low-density lipoproteins (OxLDL) and phosphocholine (PC) by enzyme linked immune assay in 663 patients with unprovoked VTE, who were prospectively followed after discontinuation of anticoagulation for a median of 8...
October 17, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29044623/retention-behavior-of-flavonoids-on-immobilized-artificial-membrane-chromatography-and-correlation-with-cell-based-permeability
#6
Fotios Tsopelas, Maria Tsagkrasouli, Pavlos Poursanidis, Maria Pitsaki, George Vasios, Panagiotis Danias, Irene Panderi, Anna Tsantili-Kakoulidou, Constantinos Giaginis
The aim of the study was to investigate IAM retention mechanism for a set of flavonoids and to evaluate the potential of IAM chromatography to model Caco-2 permeability. For this purpose, the retention behavior of 41 flavonoid analogues on two immobilized artificial membrane (IAM) stationary phases, IAM.PC.MG and IAM.PC.DD2, was investigated. Correlations between retention factors, logkw(IAM) and octanol- water partitioning (logP) were established and the role of hydroxyl groups of flavonoids to the underlying retention mechanism was explored...
October 18, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29044208/growth-factors-regulate-phospholipid-biosynthesis-in-human-fibroblast-like-synoviocytes-obtained-from-osteoarthritic-knees
#7
Katarzyna D Sluzalska, Gerhard Liebisch, Jochen Wilhelm, Bernd Ishaque, Holger Hackstein, Gerd Schmitz, Markus Rickert, Juergen Steinmeyer
Elevated levels of growth factors and phospholipids (PLs) have been found in osteoarthritic synovial fluid (SF), although the metabolic regulation of PLs is currently unknown. This study aimed to determine the effects of growth factors on the biosynthesis of PLs by fibroblast-like synoviocytes (FLS) obtained from human osteoarthritic knee joints. Electrospray ionization tandem mass spectrometry was applied to analyse the newly synthesized PLs. In the presence of stable isotope-labelled PL precursors, cultured FLS were treated with either transforming growth factor-β1 (TGF-β1), bone morphogenetic protein (BMP)-2, BMP-4, BMP-7 or insulin-like growth factor-1 (IGF-1) alone or in combination with specific inhibitors of cell signalling pathways...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043395/measuring-flow-hemodynamic-indices-and-oxygen-consumption-in-children-with-pulmonary-hypertension-a-comparison-of-catheterization-and-phase-contrast-mri
#8
Michal Schäfer, Uyen Truong, Lorna P Browne, Gareth J Morgan, Michael Ross, Richard Ing, Kendall S Hunter, Vitaly O Kheyfets, Steven H Abman, D Dunbar Ivy, Neil Wilson
We sought to compare pulmonary flow hemodynamic indices obtained by Fick and thermodilution catheterization techniques with phase-contrast MRI (PC-MRI) in children with diverse etiologies of pulmonary arterial hypertension (PAH). Calculation of pulmonary flow ([Formula: see text]) using the Fick principle in most catheter laboratories relies on an estimate of oxygen consumption which may limit its reliability. Flow hemodynamic indices acquired from thirty patients with PAH who underwent successful same-day PC-MRI and catheterization were evaluated for absolute and percent bias...
October 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29042533/a-new-electrode-design-for-ambipolar-injection-in-organic-semiconductors
#9
Thangavel Kanagasekaran, Hidekazu Shimotani, Ryota Shimizu, Taro Hitosugi, Katsumi Tanigaki
Organic semiconductors have attracted much attention for low-cost, flexible and human-friendly optoelectronics. However, achieving high electron-injection efficiency is difficult from air-stable electrodes and cannot be equivalent to that of holes. Here, we present a novel concept of electrode composed of a bilayer of tetratetracontane (TTC) and polycrystalline organic semiconductors (pc-OSC) covered by a metal layer. Field-effect transistors of single-crystal organic semiconductors with the new electrodes of M/pc-OSC/TTC (M: Ca or Au) show both highly efficient electron and hole injection...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29042502/lipopolysaccharide-from-crypt-specific-core-microbiota-modulates-the-colonic-epithelial-proliferation-to-differentiation-balance
#10
Tomoaki Naito, Céline Mulet, Cristina De Castro, Antonio Molinaro, Azadeh Saffarian, Giulia Nigro, Marion Bérard, Mélanie Clerc, Amy B Pedersen, Philippe J Sansonetti, Thierry Pédron
We identified a crypt-specific core microbiota (CSCM) dominated by strictly aerobic, nonfermentative bacteria in murine cecal and proximal colonic (PC) crypts and hypothesized that, among its possible functions, it may affect epithelial regeneration. In the present work, we isolated representative CSCM strains using selective media based upon our initial 16S rRNA-based molecular identification (i.e., Acinetobacter, Delftia, and Stenotrophomonas). Their tropism for the crypt was confirmed, and their influence on epithelial regeneration was demonstrated in vivo by monocolonization of germfree mice...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29042190/hematopoietic-stem-progenitor-involvement-in-retinal-microvascular-repair-during-diabetes-implications-for-bone-marrow-rejuvenation
#11
Ashay D Bhatwadekar, Yaqian Duan, Maria Korahw, Jeffrey S Thinschmidt, Ping Hu, Sameer P Leley, Sergio Caballero, Lynn Shaw, Julia Busik, Maria B Grant
The widespread nature of diabetes affects all organ systems of an individual including the bone marrow. Long-term damage to the cellular and extracellular components of the bone marrow leads to a rapid decline in the bone marrow-hematopoietic stem/progenitor cells (HS/PCs) compartment. This review will highlight the importance of bone marrow microenvironment in maintaining bone marrow HS/PC populations and the contribution of these key populations in microvascular repair during the natural history of diabetes...
October 14, 2017: Vision Research
https://www.readbyqxmd.com/read/29042168/autonomous-bone-reposition-around-anatomical-landmark-for-robot-assisted-orthognathic-surgery
#12
Sang-Yoon Woo, Sang-Jeong Lee, Ji-Yong Yoo, Jung-Joon Han, Soon-Jung Hwang, Kyung-Hoe Huh, Sam-Sun Lee, Min-Suk Heo, Soon-Chul Choi, Won-Jin Yi
The purpose of this study was to develop a new method for enabling a robot to assist a surgeon in repositioning a bone segment to accurately transfer a preoperative virtual plan into the intraoperative phase in orthognathic surgery. We developed a robot system consisting of an arm with six degrees of freedom, a robot motion-controller, and a PC. An end-effector at the end of the robot arm transferred the movements of the robot arm to the patient's jawbone. The registration between the robot and CT image spaces was performed completely preoperatively, and the intraoperative registration could be finished using only position changes of the tracking tools at the robot end-effector and the patient's splint...
September 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29042070/geriatric-palliative-care-meeting-the-needs-of-a-growing-population
#13
Rebecca M Saracino, Mei Bai, Leslie Blatt, Larry Solomon, Ruth McCorkle
The implementation of effective geriatric palliative care (PC) services will be increasingly important as the number of patients ages ≥65 years continues to grow. However, literature characterizing the utilization of PC services by older adults remains scant. The objective of these analyses was to characterize the nature and outcomes of PC services for older adults. A retrospective analysis of records of inpatient PC consultations provided to patients ≥65 years at an academic hospital was performed (N = 743)...
October 14, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29041640/fiber-optic-mechanical-deformation-sensors-employing-perpendicular-photonic-crystals
#14
Roxana-Mariana Beiu, Valeriu Beiu, Virgil-Florin Duma
Existing fiber optics (FOs)-based sensors, including mechanical deformation ones rely on structures embedded along the length of the FO. In this paper, we introduce and evaluate photonic crystals (PCs) embedded into FO cores acting as mechanical deformation sensors which are departing from this classical approach as the PCs are perpendicular to the length of the FO. Another noteworthy difference from classical FO-PC based sensors is that while classical ones rely on amplitude variations, the ones presented here use the phase variations of the electromagnetic components for assessing mechanical deformations...
September 18, 2017: Optics Express
https://www.readbyqxmd.com/read/29041630/unidirectional-edge-states-in-topological-honeycomb-lattice-membrane-photonic-crystals
#15
P Duke Anderson, Ganapathi Subramania
Photonic analogs of electronic systems with topologically non-trivial behavior such as unidirectional scatter-free propagation has tremendous potential for transforming photonic systems. Like in electronics topological behavior can be observed in photonics for systems either preserving time-reversal (TR) symmetry or explicitly breaking it. TR symmetry breaking requires magneto-optic photonics crystals (PC) or generation of synthetic gauge fields. For on-chip photonics that operate at optical frequencies both are quite challenging because of poor magneto-optic response of materials or substantial nanofabrication challenges in generating synthetic gauge fields...
September 18, 2017: Optics Express
https://www.readbyqxmd.com/read/29041463/real-time-multi-target-ranging-based-on-chaotic-polarization-laser-radars-in-the-drive-response-vcsels
#16
Dongzhou Zhong, Geliang Xu, Wei Luo, Zhenzhen Xiao
According to the principle of complete chaos synchronization and the theory of Hilbert phase transformation, we propose a novel real-time multi-target ranging scheme by using chaotic polarization laser radar in the drive-response vertical-cavity surface-emitting lasers (VCSELs). In the scheme, to ensure each polarization component (PC) of the master VCSEL (MVCSEL) to be synchronized steadily with that of the slave VCSEL, the output x-PC and y-PC from the MVCSEL in the drive system and those in the response system are modulated by the linear electro-optic effect simultaneously...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29041246/quantum-dot-emission-modulation-using-piezoelectric-photonic-crystal-mems-resonators
#17
Gloria G See, Anming Gao, Lu Xu, Ralph Nuzzo, Songbin Gong, Brian T Cunningham
Quantum dots (QDs) integration into photonic devices requires varied approaches to control and modulate their emission. We demonstrate voltage-tunable PC structures with integrated QDs over suspended piezoelectric aluminum nitride thin film resonators that modulate PC enhancement at MHz frequencies. When the piezoelectric device is actuated at its resonant mechanical frequency, the extracted QD emission direction is likewise modulated via the optical resonant frequency of the PC. Modulation uses nanometer-scale mechanical displacements, offering the potential for greater switching speed and improved mechanical robustness that is not subject to the effects of stiction with a scalable fabrication approach...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29041231/bistable-four-wave-mixing-response-in-a-semiconductor-quantum-dot-coupled-to-a-photonic-crystal-nanocavity
#18
Jian-Bo Li, Si Xiao, Shan Liang, Meng-Dong He, Jian-Hua Luo, Nam-Chol Kim, Li-Qun Chen
We perform a theoretical study of the bistable four-wave mixing (FWM) response in a coupled system comprised of a semiconductor quantum dot (SQD) and a photonic crystal (PC) nanocavity in which the SQD is embedded. It is shown that the shape of the FWM spectrum can switch among single-peaked, double-peaked, triple-peaked, and four-peaked arising from the vacuum Rabi splitting and the exciton-nanocavity coupling. Especially, we map out bistability phase diagrams within a parameter subspace of the system, and find that it is easy to turn on or off the bistable FWM response by only adjusting the excitation frequency or the pumping intensity...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29040878/c-phycocyanin-supplementation-during-in%C3%A2-vitro-maturation-enhances-pre-implantation-developmental-competence-of-parthenogenetic-and-cloned-embryos-in-pigs
#19
Shuang Liang, Jing Guo, Yong Xun Jin, Bao Yuan, Jia-Bao Zhang, Nam-Hyung Kim
C-Phycocyanin (C-PC), a protein from green microalgae, has been suggested to possess various biological activities, including antioxidant and free radical scavenging properties. The aim of the current study was to explore the effects of C-PC on the maturation of porcine oocytes and subsequent developmental competence after parthenogenetic activation and somatic cell nuclear transfer (SCNT) as well as the underlying mechanisms. There was no significant improvement in nuclear maturation rates between the control and C-PC supplementation groups (1, 3, 5, 10 μg/mL)...
September 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/29040839/effects-of-the-dietary-carbohydrate-fat-ratio-on-plasma-phosphatidylcholine-profiles-in-human-and-mouse
#20
Mizuki Inoue, Nanami Senoo, Tomoki Sato, Yuri Nishimura, Takumi Nakagawa, Noriyuki Miyoshi, Toshinao Goda, Akihito Morita, Shinji Miura
Phosphatidylcholines (PCs), a major class of human plasma phospholipids, are composed of highly diverse fatty acids. Because the dietary carbohydrate-fat ratio alters the hepatic fatty acid metabolism, plasma fatty acids that bind PCs, which are secreted as lipoproteins from the liver, may be affected by long-term consumption of a high-carbohydrate diet or a high-fat diet. Therefore, in this study, we profiled the plasma PC species comprehensively in formulated dieting conditions to identify those phospholipid molecules that reflect the dietary carbohydrate-fat ratio...
September 15, 2017: Journal of Nutritional Biochemistry
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