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https://www.readbyqxmd.com/read/28437754/ion-concentration-effect-na-and-cl-on-lipid-vesicle-formation
#1
Qiong Wang, Wenman Li, Ning Hu, Xi Chen, Ting Fan, Zhenyu Wang, Zhong Yang, Marcos A Cheney, Jun Yang
Lipid vesicle formation is known to be suppressed in salt solutions, but the mechanism of this phenomenon remains unclear. In order to better understand this issue, the effect of salt concentrations (0-800mM) of sodium chloride on the behavior of L-α-phosphatidylcholine (PC) in aqueous solution was investigated in this work. The results showed that fusion among vesicles, micelles and bilayers may be essential for vesicle formation. With addition of ions and an increase in ion concentration, the lipids became constrained in lateral movement and packed increasingly tightly...
April 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28437031/patient-reported-outcome-pro-questionnaires-for-men-who-have-radical-surgery-for-prostate-cancer-a-conceptual-review-of-existing-instruments
#2
REVIEW
Evangelia Protopapa, Jan van der Meulen, Caroline M Moore, Sarah C Smith
OBJECTIVES: To critically review conceptual frameworks for available patient reported outcome (PRO) questionnaires in men having radical prostatectomy; psychometrically evaluate each questionnaire; identify whether each is appropriate for use at the level of the individual patient. MATERIALS AND METHODS: We searched PubMed, the Reports and Publications database of the University of Oxford Patient Reported Outcomes Measurement Group and the website of the International Consortium for Health Outcomes Measurement (ICHOM) for psychometric reviews of prostate cancer specific PRO questionnaires...
April 24, 2017: BJU International
https://www.readbyqxmd.com/read/28436742/training-pediatric-fellows-in-palliative-care-a-pilot-comparison-of-simulation-training-and-didactic-education
#3
Katharine E Brock, Harvey J Cohen, Barbara M Sourkes, Julie J Good, Louis P Halamek
BACKGROUND: Pediatric fellows receive little palliative care (PC) education and have few opportunities to practice communication skills. OBJECTIVE: In this pilot study, we assessed (1) the relative effectiveness of simulation-based versus didactic education, (2) communication skill retention, and (3) effect on PC consultation rates. DESIGN: Thirty-five pediatric fellows in cardiology, critical care, hematology/oncology, and neonatology at two institutions enrolled: 17 in the intervention (simulation-based) group (single institution) and 18 in the control (didactic education) group (second institution)...
April 24, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28436718/design-of-a-novel-curcumin-soybean-phosphatidylcholine-complex-based-targeted-drug-delivery-systems
#4
Jiajiang Xie, Yanxiu Li, Liang Song, Zhou Pan, Shefang Ye, Zhenqing Hou
Recently, the global trend in the field of nanomedicine has been toward the design of combination of nature active constituents and phospholipid (PC) to form a therapeutic drug-phospholipid complex. As a particular amphiphilic molecular complex, it can be a unique bridge of traditional dosage-form and novel drug delivery system. In thisarticle, on the basis of drug-phospholipid complex technique and self-assembly technique, we chose a pharmacologically safe and low toxic drug curcumin (CUR) to increase drug-loading ability, achieve controlled/sustained drug release and improve anticancer activity...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28436214/a-comparison-of-the-cost-of-primary-closure-or-rectus-abdominis-myocutaneous-flap-closure-of-the-perineum-after-abdominoperineal-excision
#5
John Woodfield, Michael Hulme-Moir, Jasen Ly
AIM: Perineal wound complications following abdominoperineal resection continue to be a major challenge.. The aim of this study was to compare the clinical outcomes and cost of primary closure (PC) and rectus abdominis myocutaneous flap reconstruction (RAM). METHOD: Retrospective case review of consecutive patients by one surgeon over 11 years. Patient demographics, risk factors, operative details and complications were identified. Inpatient and outpatient costs were calculated...
April 24, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28436079/-l-2-c2-p2-dicarbondiphosphide-stabilized-by-n-heterocyclic-carbenes-or-cyclic-diamido-carbenes
#6
Zhongshu Li, Xiaodan Chen, Diego M Andrada, Gernot Frenking, Zoltán Benkö, Yaqi Li, Jeffrey R Harmer, Cheng-Yong Su, Hansjörg Grützmacher
Carbon phosphides, Cn Pm , may have highly promising electronic, optical, and mechanical properties, but they are experimentally almost unexplored materials. Phosphaheteroallenes stabilized by N-heterocyclic carbenes undergo a one-electron reduction to yield compounds of the type (L)2 C2 P2 with diverse structures. The use of imidazolylidenes as ligands L give complexes with a central four-membered ring C2 P2 , while more electrophilic cyclic diamidocarbenes (DAC) give a compound with an acyclic π-conjugated CP-PC unit...
April 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28436066/reduction-by-coffee-consumption-of-prostate-cancer-risk-evidence-from-the-moli-sani-cohort-and-cellular-models
#7
George Pounis, Claudio Tabolacci, Simona Costanzo, Martina Cordella, Marialaura Bonaccio, Livia Rago, Daniela D'Arcangelo, Augusto Filippo Di Castelnuovo, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, Francesco Facchiano
Meta-analytic data on the effect of coffee in prostate cancer risk are controversial. Caffeine as a bioactive compound of coffee has not yet been studied in deep in vitro. Our study aimed at evaluating in a population cohort the effect of Italian-style coffee consumption on prostate cancer risk and at investigating in vitro the potential antiproliferative and antimetastatic activity of caffeine on prostate cancer cell lines. 6,989 men of the Moli-sani cohort aged ≥50 years were followed for a mean of 4.24 ± 1...
April 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28435620/the-effect-of-resin-cement-type-and-cleaning-method-on-the-shear-bond-strength-of-resin-cements-for-recementing-restorations
#8
Roodabeh Koodaryan, Ali Hafezeqoran, Amin Khakpour Maleki
PURPOSE: This laboratory study assessed the effect of different dentin cleaning procedures on shear bond strength of resin cements for recementing prosthesis. MATERIALS AND METHODS: 4 × 4 flat surface was prepared on the labial surface of 52 maxillary central incisors. Metal frames (4 × 4 × 1.5 mm) were cast with nickel-chromium alloy. All specimens were randomly divided into 2 groups to be cemented with either Panavia F2.0 (P) or RelyX Ultimate (U) cement. The initial shear bond strength was recorded by Universal Testing Machine at a crosshead speed of 0...
April 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28434889/depletion-of-tm6sf2-disturbs-membrane-lipid-composition-and-dynamics-in-huh7-hepatoma-cells
#9
Hanna Ruhanen, P A Nidhina Haridas, Eeva-Liisa Eskelinen, Ove Eriksson, Vesa M Olkkonen, Reijo Käkelä
A polymorphism of TM6SF2 associates with hepatic lipid accumulation and reduction of triacylglycerol (TAG) secretion, but the function of the encoded protein has remained enigmatic. We studied the effect of stable TM6SF2 knock-down on the lipid content and composition, mitochondrial fatty acid oxidation and organelle structure of HuH7 hepatoma cells. Knock-down of TM6SF2 resulted in intracellular accumulation of TAGs, cholesterol esters, phosphatidylcholine (PC) and phosphatidylethanolamine. In all of these lipid classes, polyunsaturated lipid species were significantly reduced while saturated and monounsaturated species increased their proportions...
April 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28434851/long-term-audit-of-platelet-consumption-in-a-university-hospital
#10
A K Al-Ghumlas, A K Al Momen, M Badri, A G Abdel Gader
OBJECTIVES: To determine the long-term trend in platelet consumption in a university hospital. MATERIALS AND METHODS: The annual consumption of platelets concentrate (PC) was analyzed over 23 years (1985-2007) in King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. RESULTS: The total 23 years consumption was 100,466 units of PC. Consumption went through 3 phases: the first, 1985-1994: the annual consumption increased from 1706 to 5912 which coincided with the increase in the number of patient admissions; the second, 1994-2003:featured a remarkable drop (48...
April 20, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28433954/lipidomic-profile-in-three-species-of-dinoflagellates-amphidinium-carterae-cystodinium-sp-and-peridinium-aciculiferum-containing-very-long-chain-polyunsaturated-fatty-acids
#11
Tomáš Řezanka, Jaromír Lukavský, Linda Nedbalová, Karel Sigler
This study describes the identification of very long chain polyunsaturated fatty acids (VLCPUFAs) in three strains of dinoflagellates (Amphidinium carterae, Cystodinium sp., and Peridinium aciculiferum). The strains were cultivated and their lipidomic profiles were obtained by high resolution mass spectrometry with the aid of positive and negative electrospray ionization (ESI) mode by Orbitrap apparatus. Hydrophilic interaction liquid chromatography (HILIC/ESI) was used to separate major lipid classes of the three genera of dinoflagellates by neutral loss scan showing the ion [M + H-28:8](+), where 28:8 was octacosaoctaenoic acid, and by precursor ion scanning of ions at m/z 407, which was an ion corresponding to the structure of acyl of 28:8 acid (C27H39COO(-))...
April 20, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28433894/a-functional-snp-mcp-1-2518a-g-predispose-to-renal-disorder-in-indian-systemic-lupus-erythematosus-patients
#12
Vinod D Umare, Vandana D Pradhan, Anjali G Rajadhyaksha, Kanjaksha Ghosh, Anita H Nadkarni
Systemic Lupus Erythematosus (SLE) is a clinically heterogeneous chronic, inflammatory autoimmune disorder that affects multiple organs where exact etiology of the disease is not yet clearly understood. Various evidences suggest that genetic polymorphisms in inflammatory mediators like cytokines and chemokines may influence development of the disease. Here, we investigated whether functional polymorphism at the Monocyte Chemoattractant Protein-1 (MCP-1) regulatory region associates with disease phenotype in Indian SLE patients...
April 20, 2017: Cytokine
https://www.readbyqxmd.com/read/28433809/biocorona-formation-on-gold-nanoparticles-modulates-human-proximal-tubule-kidney-cell-uptake-cytotoxicity-and-gene-expression
#13
M T Ortega, J E Riviere, K Choi, N A Monteiro-Riviere
Gold nanoparticles (AuNP) adsorb macromolecules to form a protein corona (PC) after systemic delivery, to which the kidney as the primary excretory organ is constantly exposed. The role of the PC on AuNP cell uptake and toxicity was investigated in vitro in human proximal tubule cells (HPTC) using 40 and 80nm branched polyethylenimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coated AuNP with or without (bare) PCs composed of human plasma (HP) or human serum albumin (HSA) for 0.25 to 24h. Time-dependent intracellular uptake, assessed by ICP-MS showed PC modulated cell uptake and cytotoxicity; with bare 40nm BPEI-AuNP showing the greatest responses...
April 19, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28432987/multimodal-imaging-of-language-reorganization-in-patients-with-left-temporal-lobe-epilepsy
#14
Yu-Hsuan A Chang, Nobuko Kemmotsu, Kelly M Leyden, N Erkut Kucukboyaci, Vicente J Iragui, Evelyn S Tecoma, Leena Kansal, Marc A Norman, Rachelle Compton, Tobin J Ehrlich, Vedang S Uttarwar, Anny Reyes, Brianna M Paul, Carrie R McDonald
This study explored the relationships among multimodal imaging, clinical features, and language impairment in patients with left temporal lobe epilepsy (LTLE). Fourteen patients with LTLE and 26 controls underwent structural MRI, functional MRI, diffusion tensor imaging, and neuropsychological language tasks. Laterality indices were calculated for each imaging modality and a principal component (PC) was derived from language measures. Correlations were performed among imaging measures, as well as to the language PC...
April 19, 2017: Brain and Language
https://www.readbyqxmd.com/read/28432774/comprehensive-two-dimensional-pc-3-prostate-cancer-cell-membrane-chromatography-for-screening-anti-tumor-components-from-radix-sophorae-flavescentis
#15
Qiang Wang, Junnan Xu, Xiang Li, Dawei Zhang, Yong Han, Xu Zhang
Radix Sophorae flavescentis is generally used for the treatments of different stages of prostate cancer in China. It has ideal effects when combined with surgical treatment and chemotherapy. However, its active components are still ambiguous. We devised a comprehensive two-dimensional PC-3 prostate cancer cell membrane chromatography system for screening anti-prostate cancer components in Radix Sophorae flavescentis. Gefitinib and dexamethasone were chosen as positive and negative drugs respectively for validation and optimization the selectivity and suitability of the comprehensive two-dimensional chromatographic system...
April 22, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28432449/enteroparasitoses-and-toxocarosis-affecting-children-from-mar-del-plata-city-argentina
#16
Carla Lavallén, Beatriz Brignani, Karina Riesgo, Amalia Rojas, Gabriela Colace, Martín Biscaychipi, Estela Chicote, Cristian Giuntini, Mariela Kifer, María Eugenia Del Río, Guillermo Denegri, Marcela Dopchiz
This study evaluated the existence of enteroparasitoses and toxocarosis in children of peripheral (PC) and urban communities (UC) from Mar del Plata city (Argentina) and their associations with socio-environmental conditions. A Parasite Vulnerability Index (PVI) was elaborated using variables such as overcrowding, floor type, drinking water source, wastewater disposal, solid waste disposal, presence of animals and schooling level. The PC evidenced statistically significant higher frequencies of families with high (38...
April 21, 2017: EcoHealth
https://www.readbyqxmd.com/read/28432222/low-expression-of-hexokinase-2-is-associated-with-false-negative-fdg-positron-emission-tomography-in-multiple-myeloma
#17
Leo Rasche, Edgardo Angtuaco, James E McDonald, Amy Buros, Caleb Stein, Charlotte Pawlyn, Sharmilan Thanendrarajan, Carolina Schinke, Rohan Samant, Shmuel Yaccoby, Brian Walker, Joshua Epstein, Maurizio Zangari, Frits van Rhee, Tobias Meissner, Hartmut Goldschmidt, Kari Hemminki, Richard Houlston, Bart Barlogie, Faith E Davies, Gareth J Morgan, Niels Weinhold
18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) and diffusion weighted magnetic resonance imaging with background signal suppression (DWIBS) are two powerful functional imaging modalities in the evaluation of the malignant plasma cell (PC) disease multiple myeloma (MM). Preliminary observations have suggested that MM patients with extensive disease according to DWIBS may be reported as being disease-free on FDG-PET ("PET-false-negative"). The aim of this study was to describe the proportion of PET-false-negativity in a representative set of 227 newly diagnosed MM patients with simultaneous assessment of FDG-PET and DWIBS, and to identify tumor-intrinsic features associated with this pattern...
April 21, 2017: Blood
https://www.readbyqxmd.com/read/28432089/preparing-future-doctors-for-palliative-care-views-of-course-organisers
#18
Steven Walker, Jane Gibbins, Paul Paes, Stephen Barclay, Astrid Adams, Madawa Chandratilake, Faye Gishen, Philip Lodge, Bee Wee
BACKGROUND: Effective training at medical school is essential to prepare new doctors to safely manage patients with palliative care (PC) and end of life care (EOLC) needs. The contribution of undergraduate PC course organisers is central but their collective views regarding role are unknown. OBJECTIVE: To survey attitudes of PC course organisers regarding their course, organisation, the adequacy of training provided and level of personal satisfaction. METHODS: An anonymised, multifactorial, web-based questionnaire was devised, tested, modified and then sent to lead PC course organisers at all UK medical schools...
April 21, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28431881/design-and-synthesis-of-1-2-3-triazolo-phenanthrene-hybrids-as-cytotoxic-agents
#19
Niggula Praveen Kumar, Shalini Nekkanti, S Sujana Kumari, Pankaj Sharma, Nagula Shankaraiah
A series of new 1,2,3-triazolo-phenanthrene hybrids has been synthesized by employing Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. These compounds were evaluated for their in vitro cytotoxic potential against various human cancer cell lines viz. lung (A549), prostate (PC-3 and DU145), gastric (HGC-27), cervical (HeLa), triple negative breast (MDA-MB-231, MDA-MB-453) and breast (BT-549, 4T1) cells. Among the tested compounds, 7d displayed highest cytotoxicity against DU145 cells with IC50 value of 1...
April 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28431146/response-of-broiler-chickens-fed-wheat-based-diets-to-xylanase-supplementation
#20
G Gonzalez-Ortiz, D Sola-Oriol, M Martinez-Mora, J F Perez, M R Bedford
The objective of this study was to evaluate the effect of xylanase supplementation on performance, footpad score (FPS), nutrient digestibility, and intestinal morphometry in broiler chickens. Two-hundred-eighty-eight Ross 308 broiler chicks (one d old) were placed in one of 3 experimental treatments: positive control (PC), negative control (NC) (-150 kcal/kg), and XYL (NC supplemented with xylanase). Each treatment had 8 replicates with 12 animals each. Starter (zero to 21 d) and grower (21 to 42 d) diets, based on wheat and soy-bean meal, were available ad libitum...
April 18, 2017: Poultry Science
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