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F Zhang, X C Sun, C D Lu, W Zhang, H Shao, Z X Wang
Objective: To study the relationship between XRCC1 gene polymorphism and DNA damage in peripheral blood lymphocytes of workers exposed to coal tar pitch. Methods: 203 coal tar asphalt device operation area workers (exposure group) and 76 logistics management personnel (control group) as the research ob-ject, determination of 1-hydroxypyrene concentrations in the urine as polycyclic aromatic hydrocarbons expo-sure dose, using the alkaline comet assay evaluation a peripheral blood lymphocyte DNA damage degree, using TaqMan MGB real time PCR method to detect XRCC1 gene 3 loci (XRCC1-194, XRCC1-280 and XRCC1-399) single nucleotide polymorphism...
January 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
H Zhao, L Song, Y Qiang, H R Liu, F Y Qiu, X Z Li, H Song
Objective: To investigate the association between occupational stress and activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patients with metabolic syndrome. Methods: A case-control study was performed. According to inclusion and exclusion criteria, among the staff members of enterprises and public institutions aged 20~60 years who underwent physical examination in The Affiliated Hospital of Ningxia Medical University and The People's Hospital of Wuzhong from October 2011 to October 2012, 622 patients with metabolic syndrome who did not have a blood relationship with each other were enrolled as case group, and 600 healthy staff members who also did not have a blood relationshipwith each otherwere enrolled as control group...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Y H Li, G S Chen, J Jiao, W H Zhou, H Wu, G Z Gu, H L Zhang, Y X Zheng, S F Yu
Objective: To investigate the association between the single nucleotide polymorphisms (SNPs) at rs1043618, rs2075800, and rs2763979 in human heat shock protein 70 (HSP70) gene and susceptibility to noise-induced hearing loss (NIHL) . Methods: A case-control study was performed, and 5 934 workers exposed to noise in an iron and steel plant in Henan, China, who underwent physical examination from 2006 to 2015, were enrolled as study subjects. According to the criteria of binaural average high - frequency (3000, 4000, and 6000 Hz) hearing threshold≥40 dB (HL) and monauralaverage speech-frequency (500, 1000, 2000 Hz) hearing threshold≥26 dB (HL) on the basis of binauralhigh frequency loss measured by pure tone audiometry, as well as the exclusion of NIHL, a total of 286 workers were enrolled as hearing loss group; after the adjustment for sex, type of work, age (difference≤5 years) , and working years of noise exposure (difference ≤2 years) , 286 workers were enrolled as control group...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
J Jiao, G Z Gu, G S Chen, Y X Zheng, H L Zhang, Q Geng, Y B Cheng, S F Yu
Objective: To investigate the association between serum magnesium ion level and risk of noise-induced hearing loss (NIHL) . Methods: Acohort study was performed for 7 445 workers exposed to noise in the steelmaking and steel rolling workshops of an iron and steel enterprise in Henan Province, China. The follow-up time was from January 1, 2006 to December 31, 2015. The workers with a binaural average high-frequency hearing threshold of ≥40 dB (HL) were enrolled as case group, and those with a binaural average high-frequency hearing threshold of <35 dB (HL) and a binaural average speech frequency of ≤25 dB (HL) were enrolled as control group...
December 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Tianwei Jiang, Ruihuan Wu, Song Yu, Dongsheng Wang, Wanyi Gu
Traditional microwave photonic systems cannot implement frequency up-conversion with phase tunable capability, which plays an important role for phase array beamforming. Here, a method that can implement both upconversion and downconversion with a broadband full-degree phase-shift capability by constructing an optical path with a Hilbert transform function is presented. Owing to the Hilbert transform path, the dual-drive Mach-Zehnder modulator (DMZM) bias information, which initially influences the amplitudes of the output signals, are transferred to their phases...
February 20, 2017: Optics Express
Peixuan Li, Wei Pan, Xihua Zou, Lianshan Yan, Bin Luo, Bing Lu
A tunable microwave photonic duplexer (MPD) for full-duplex radio-over-fiber access is proposed and experimentally demonstrated. The proposed MPD is implemented by two single-bandpass microwave photonic filters (MPFs) to separate the transmit (Tx) and receive (Rx) channels. More specifically, a broadband optical source (BOS) is spectrally sliced by a differential-group-delay interferometer (DGDI) and a Mach-Zehnder interferometer (MZI) to form two tunable single-bandpass MPFs with different central frequencies...
February 20, 2017: Optics Express
Wenda Cui, Hongyan Wang, Kai Han, Weihong Hua, Xiaojun Xu
The excitation and emission properties of optical materials can be adjusted by nanostructures and to achieve high optical efficiency in the optically pump laser, especially for lasers with short absorption length and high pump threshold. We present and theoretically investigate a Yb-doped thin film on a 1D grating structure in this paper. High reflectivity at the pump and emission wavelength are realized simultaneously and in terms of the guided-mode resonance theory, the local field of high reflected light is enhanced which will increase the absorption of associated laser wavelength...
February 20, 2017: Optics Express
R Zou, M Wang, S L Wang, S Li, C Zhang, L Deng, Y F Lu, K P Chen
Laser shock micro-forming is a non-thermal laser forming method that uses laser-induced shockwave to modify surface properties and to adjust shapes and geometry of work pieces. The magnitude and spatial distribution of the laser-induced shockwaves depend on the energy profiles of the laser beam focused on sample surfaces. In this paper, we present an adaptive optical technique to engineer spatial profiles of laser beams to control the shapes, sizes, and locations of the laser-induced shockwaves and the resulting forming features...
February 20, 2017: Optics Express
Zhiping Wang, Jinyu Chen, Benli Yu
We investigate the two-dimensional (2D) and three-dimensional (3D) atom localization behaviors via spontaneously generated coherence in a microwave-driven four-level atomic system. Owing to the space-dependent atom-field interaction, it is found that the detecting probability and precision of 2D and 3D atom localization behaviors can be significantly improved via adjusting the system parameters, the phase, amplitude, and initial population distribution. Interestingly, the atom can be localized in volumes that are substantially smaller than a cubic optical wavelength...
February 20, 2017: Optics Express
Jaël Pauwels, Guy Verschaffelt
We report on a novel speckle reduction scheme using microlens arrays as screen material for application in laser-based projection systems. The scheme is based on properly adjusting the coherence properties on the screen: when the coherence area on the microlens-array screen is smaller than the microlens footprint, there is no interference between the fields emitted by the different microlenses and as a result no speckle is formed. We measured and modelled the speckle properties of microlens arrays with regular and irregular structure and lens sizes, and also a paper screen for comparison...
February 20, 2017: Optics Express
Yan Kai Zhong, Sze Ming Fu, Weiming Huang, Ding Rung, Jian Yi-Wen Huang, Parag Parashar, Albert Lin
While a broadband metamaterial perfect absorber (MPA) has been implemented and proposed intensively in recent years, an ultra-broadband perfect absorber with polarization selectivity has not been realized in literature. In this work, we propose a configuration of polarization-selective (PS) MPA with ultra-wide absorption bandwidth. The aluminum wire grid is integrated on top of the ultrathin-metal-dielectric stacking. The transverse electric (TE) wave is blocked due to the requirement of zero tangential electric field at the metal surface...
February 20, 2017: Optics Express
Chih-Yen Chiang, Kun-Hui Chen, Kai-Chun Liu, Steen Jun-Ping Hsu, Chia-Tai Chan
Total knee arthroplasty (TKA) is the most common treatment for degenerative osteoarthritis of that articulation. However, either in rehabilitation clinics or in hospital wards, the knee range of motion (ROM) can currently only be assessed using a goniometer. In order to provide continuous and objective measurements of knee ROM, we propose the use of wearable inertial sensors to record the knee ROM during the recovery progress. Digitalized and objective data can assist the surgeons to control the recovery status and flexibly adjust rehabilitation programs during the early acute inpatient stage...
February 22, 2017: Sensors
Erika P S Freitas, Aline T O Cunha, Sephora L S Aquino, Lucia F C Pedrosa, Severina C V C Lima, Josivan G Lima, Maria G Almeida, Karine C M Sena-Evangelista
Metabolic syndrome (MS) involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls. We performed clinical and anthropometric assessments and obtained lipid, glycemic, and inflammatory profiles. We also evaluated zinc intake, plasma zinc, erythrocyte zinc, and 24-h urinary zinc excretion. The average zinc intake was significantly lower in the MS group (p < 0...
February 22, 2017: Nutrients
Geneviève Huard, Kishore Iyer, Jang Moon, John T Doucette, Vinay Nair, Thomas D Schiano
INTRODUCTION: Using data from the SRTR, cumulative incidence, risk factors for, and impact on survival of severe CKD in ITx recipients were assessed. METHODS: First-time adult ITx recipients transplanted in the United States between 01/01/1990 and 12/31/2012 were included. Severe CKD after ITx was defined as: GFR <30 ml/min/1.73m(2) , chronic hemodialysis initiation, or KTx. Survival analysis and extended Cox model were conducted. RESULTS: The cumulative incidence of severe CKD one, five and ten years after ITx was 3...
February 27, 2017: Clinical Transplantation
George A Khoury, James Smadbeck, Chris A Kieslich, Alexandra J Koskosidis, Yannis A Guzman, Phanourios Tamamis, Christodoulos A Floudas
Protein structure refinement is the challenging problem of operating on any protein structure prediction to improve its accuracy with respect to the native structure in a blind fashion. Although many approaches have been developed and tested during the last four CASP experiments, a majority of the methods continue to degrade models rather than improve them. Princeton_TIGRESS (Khoury et al., Proteins, 2014) was developed previously and utilizes separate sampling and selection stages involving Monte Carlo and molecular dynamics simulations and classification using an SVM predictor...
February 27, 2017: Proteins
A Marcer, D S Vidigal, P M A James, M-J Fortin, B Méndez-Vigo, H W M Hilhorst, L Bentsink, C Alonso-Blanco, F X Picó
To understand how adaptive evolution in life-cycle phenology operates in plants, we need to unravel the effects of geographical variation in putative agents of natural selection on life-cycle phenology by considering all key developmental transitions and their co-variation patterns. We address this goal by quantifying the temperature-driven and geographically varying relationship between seed dormancy and flowering time in the annual Arabidopsis thaliana across the Iberian Peninsula. We used data on genetic variation in two major life-cycle traits, seed dormancy (DSDS50) and flowering time (FT), in a collection of 300 A...
February 27, 2017: Plant Biology
Thomas Agoritsas, Arnaud Merglen, Nilay D Shah, Martin O'Donnell, Gordon H Guyatt
Observational studies almost always have bias because prognostic factors are unequally distributed between patients exposed or not exposed to an intervention. The standard approach to dealing with this problem is adjusted or stratified analysis. Its principle is to use measurement of risk factors to create prognostically homogeneous groups and to combine effect estimates across groups.The purpose of this Users' Guide is to introduce readers to fundamental concepts underlying adjustment as a way of dealing with prognostic imbalance and to the basic principles and relative trustworthiness of various adjustment strategies...
February 21, 2017: JAMA: the Journal of the American Medical Association
Susan M Resnick, Alvin M Matsumoto, Alisa J Stephens-Shields, Susan S Ellenberg, Thomas M Gill, Sally A Shumaker, Debbie D Pleasants, Elizabeth Barrett-Connor, Shalender Bhasin, Jane A Cauley, David Cella, Jill P Crandall, Glenn R Cunningham, Kristine E Ensrud, John T Farrar, Cora E Lewis, Mark E Molitch, Marco Pahor, Ronald S Swerdloff, Denise Cifelli, Stephen Anton, Shehzad Basaria, Susan J Diem, Christina Wang, Xiaoling Hou, Peter J Snyder
Importance: Most cognitive functions decline with age. Prior studies suggest that testosterone treatment may improve these functions. Objective: To determine if testosterone treatment compared with placebo is associated with improved verbal memory and other cognitive functions in older men with low testosterone and age-associated memory impairment (AAMI). Design, Setting, and Participants: The Testosterone Trials (TTrials) were 7 trials to assess the efficacy of testosterone treatment in older men with low testosterone levels...
February 21, 2017: JAMA: the Journal of the American Medical Association
Matthew J Budoff, Susan S Ellenberg, Cora E Lewis, Emile R Mohler, Nanette K Wenger, Shalender Bhasin, Elizabeth Barrett-Connor, Ronald S Swerdloff, Alisa Stephens-Shields, Jane A Cauley, Jill P Crandall, Glenn R Cunningham, Kristine E Ensrud, Thomas M Gill, Alvin M Matsumoto, Mark E Molitch, Rine Nakanishi, Negin Nezarat, Suguru Matsumoto, Xiaoling Hou, Shehzad Basaria, Susan J Diem, Christina Wang, Denise Cifelli, Peter J Snyder
Importance: Recent studies have yielded conflicting results as to whether testosterone treatment increases cardiovascular risk. Objective: To test the hypothesis that testosterone treatment of older men with low testosterone slows progression of noncalcified coronary artery plaque volume. Design, Setting, and Participants: Double-blinded, placebo-controlled trial at 9 academic medical centers in the United States. The participants were 170 of 788 men aged 65 years or older with an average of 2 serum testosterone levels lower than 275 ng/dL (82 men assigned to placebo, 88 to testosterone) and symptoms suggestive of hypogonadism who were enrolled in the Testosterone Trials between June 24, 2010, and June 9, 2014...
February 21, 2017: JAMA: the Journal of the American Medical Association
Michael W Kuzniewicz, Karen M Puopolo, Allen Fischer, Eileen M Walsh, Sherian Li, Thomas B Newman, Patricia Kipnis, Gabriel J Escobar
Importance: Current algorithms for management of neonatal early-onset sepsis (EOS) result in medical intervention for large numbers of uninfected infants. We developed multivariable prediction models for estimating the risk of EOS among late preterm and term infants based on objective data available at birth and the newborn's clinical status. Objectives: To examine the effect of neonatal EOS risk prediction models on sepsis evaluations and antibiotic use and assess their safety in a large integrated health care system...
February 20, 2017: JAMA Pediatrics
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