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https://www.readbyqxmd.com/read/29150995/efficacy-and-safety-of-extracranial-vein-angioplasty-in-multiple-sclerosis-a-randomized-clinical-trial
#1
Paolo Zamboni, Luigi Tesio, Stefania Galimberti, Luca Massacesi, Fabrizio Salvi, Roberto D'Alessandro, Patrizia Cenni, Roberto Galeotti, Donato Papini, Roberto D'Amico, Silvana Simi, Maria Grazia Valsecchi, Graziella Filippini
Importance: Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by restricted venous outflow from the brain and spinal cord. Whether this condition is associated with multiple sclerosis (MS) and whether venous percutaneous transluminal angioplasty (PTA) is beneficial in persons with MS and CCSVI is controversial. Objective: To determine the efficacy and safety of venous PTA in patients with MS and CCSVI. Design, Setting, and Participants: We analyzed 177 patients with relapsing-remitting MS; 62 were ineligible, including 47 (26...
November 18, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29146175/autobiographical-memory-sources-of-threats-in-dreams
#2
Alexandre Lafrenière, Monique Lortie-Lussier, Allyson Dale, Raphaëlle Robidoux, Joseph De Koninck
Temporal sources of dream threats were examined through the paradigm of the Threat Simulation Theory. Two groups of young adults (18-24 years old), who did not experience severe threatening events in the year preceding their dream and reported a dream either with or without threats, were included. Participants (N = 119) kept a log of daily activities and a dream diary, indicating whether dream components referred to past experiences. The occurrence of oneiric threats correlated with the reporting of threats in the daily logs, their average severity, and the stress level experienced the day preceding the dream...
November 13, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29145189/rem-sleep-behavior-disorder
#3
Claudio L Bassetti, Panagiotis Bargiotas
Rapid eye movement sleep behavior disorder (RBD) is a brain disorder, characterized by the dream enactment during rapid eye movement (REM) sleep due to a lack of physiologic muscle atonia and increased muscle twitching. Schenk was the first to describe this disorder in 1986; however, few authors reported in the 1970-1980s loss of physiological muscle atonia combined with dream enactment in the course of brainstem disorders and as a consequence of alcoholism and antidepressant treatment. RBD affects less than 1% of the adult population, but can be found in up to 25-50% of neurodegenerative disorders including Parkinson's disease, multisystem atrophy, and dementia with Lewy body...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29140809/stem-cell-therapy-for-acute-myocardial-infarction-on-the-horizon-or-still-a-dream
#4
Kenneth M Fish, Kiyotake Ishikawa, Roger J Hajjar
No abstract text is available yet for this article.
November 14, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29140281/non-contact-sensor-for-long-term-continuous-vital-signs-monitoring-a-review-on-intelligent-phased-array-doppler-sensor-design
#5
REVIEW
Travis Hall, Donald Y C Lie, Tam Q Nguyen, Jill C Mayeda, Paul E Lie, Jerry Lopez, Ron E Banister
It has been the dream of many scientists and engineers to realize a non-contact remote sensing system that can perform continuous, accurate and long-term monitoring of human vital signs as we have seen in many Sci-Fi movies. Having an intelligible sensor system that can measure and record key vital signs (such as heart rates and respiration rates) remotely and continuously without touching the patients, for example, can be an invaluable tool for physicians who need to make rapid life-and-death decisions. Such a sensor system can also effectively help physicians and patients making better informed decisions when patients' long-term vital signs data is available...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29128282/daydreams-incorporate-recent-waking-life-concerns-but-do-not-show-delayed-dream-lag-incorporations
#6
Elaine van Rijn, Alexander M Reid, Christopher L Edwards, Josie E Malinowski, Perrine M Ruby, Jean-Baptiste Eichenlaub, Mark T Blagrove
This study investigates the time course of incorporation of waking life experiences into daydreams. Thirty-one participants kept a diary for 10 days, reporting major daily activities (MDAs), personally significant events (PSEs) and major concerns (MCs). They were then cued for daydream, Rapid Eye Movement (REM) and N2 dream reports in the sleep laboratory. There was a higher incorporation into daydreams of MCs from the previous two days (day-residue effect), but no day-residue effect for MDAs or PSEs, supporting a function for daydreams of processing current concerns...
November 8, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29125603/cell-cycle-arrest-through-indirect-transcriptional-repression-by-p53-i-have-a-dream
#7
REVIEW
Kurt Engeland
Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent years it has become evident that p53-dependent repression is controlled by the p53-p21-DREAM-E2F/CHR pathway (p53-DREAM pathway). DREAM is a transcriptional repressor that binds to E2F or CHR promoter sites. Gene regulation and deregulation by DREAM shares many mechanistic characteristics with the retinoblastoma pRB tumor suppressor that acts through E2F elements...
November 10, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29125497/quantum-brain-theory-and-the-appearing-of%C3%A2-world
#8
Gordon Globus
The appearing of world is approached via the dream world which has generally been thought to be merely derivative: a "composition" of memory traces from waking life, which are merged and fused into a dream world that in some instances can be indiscernable from the world of waking life. Two dreams are presented which challenge the composition theory of dream formation. An alternative unified theory of world appearance in both waking and dreaming is proposed, which makes use of developments in quantum brain dynamics...
November 8, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29123072/fighting-for-my-dream
#9
Evelyn Valdez-Ward
No abstract text is available yet for this article.
November 10, 2017: Science
https://www.readbyqxmd.com/read/29117888/the-rem-sleep-behavior-disorder-screening-questionnaire-validation-study-of-the-korean-version-rbdq-kr
#10
Sooyeoun You, Hye-Jin Moon, So Young Do, Yun-Kwok Wing, Jun-Sang Sunwoo, Ki-Young Jung, Yong Won Cho
STUDY OBJECTIVES: REM sleep behavior disorder (RBD) is a parasomnia that is commonly associated with neurodegenerative disorders. We aimed to validate the Hong Kong version of the self-reported RBD questionnaire (RBDQ-HK) with the Korean version (RBDQ-KR) and to investigate its clinical usefulness. METHODS: One-hundred five patients with RBD and 105 age- and sex-matched controls were enrolled. Thirty were randomly selected for a retest with the questionnaire after 2 to 4 weeks without any treatment...
November 1, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29113811/incorporating-gene-ontology-into-fuzzy-relational-clustering-of-microarray-gene-expression-data
#11
Animesh Kumar Paul, Pintu Chandra Shill
The product of gene expression works together in the cell for each living organism in order to achieve different biological processes. Many proteins are involved in different roles depending on the environment of the organism for the functioning of the cell. In this paper, we propose gene ontology (GO) annotations based semi-supervised clustering algorithm called GO fuzzy relational clustering (GO-FRC) where one gene is allowed to be assigned to multiple clusters which are the most biologically relevant behavior of genes...
November 4, 2017: Bio Systems
https://www.readbyqxmd.com/read/29113310/inference-of-time-delayed-gene-regulatory-networks-based-on-dynamic-bayesian-network-hybrid-learning-method
#12
Bin Yu, Jia-Meng Xu, Shan Li, Cheng Chen, Rui-Xin Chen, Lei Wang, Yan Zhang, Ming-Hui Wang
Gene regulatory networks (GRNs) research reveals complex life phenomena from the perspective of gene interaction, which is an important research field in systems biology. Traditional Bayesian networks have a high computational complexity, and the network structure scoring model has a single feature. Information-based approaches cannot identify the direction of regulation. In order to make up for the shortcomings of the above methods, this paper presents a novel hybrid learning method (DBNCS) based on dynamic Bayesian network (DBN) to construct the multiple time-delayed GRNs for the first time, combining the comprehensive score (CS) with the DBN model...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112515/in-response-to-measles-can-destroy-a-dream-the-case-of-the-settebello
#13
Silvio Tafuri, Leonardo Ascatigno, Maria Serena Gallone
No abstract text is available yet for this article.
October 27, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29110621/functional-germ-cells-from-non-testicular-adult-stem-cells-a-dream-or-reality
#14
Mohammad Ghasemzadeh-Hasankolaei, Mohammadreza Baghaban Eslaminejad, Maryam Ghasemzadeh-Hasankolaei
BACKGROUND: Some research studies provided evidence for the differentiation capacity of adult stem cells (ASCs) into germ cells (GCs). Since the generation of GCs from stem cells (SCs) has been proposed as a potential way for treatment of infertility, many research groups, have begun their creative studies on generation of new GCs both in vitro and in vivo, and utilized different ASC types such as bone marrow mesenchymal stem cells (BM-MSCs), skin stem cells, pancreatic stem cells, and adipose tissue MSCs...
November 6, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29109104/advocating-for-the-dream-act-why-pediatricians-should-care-and-what-they-can-do
#15
Mark Kuczewski, John D Lantos, Zarna Patel
No abstract text is available yet for this article.
November 6, 2017: Pediatrics
https://www.readbyqxmd.com/read/29108303/anesthetic-dreaming-anesthesia-awareness-and-patient-satisfaction-after-deep-sedation-with-propofol-target-controlled-infusion-a-prospective-cohort-study-of-patients-undergoing-day-case-breast-surgery
#16
Marco Cascella, Roberta Fusco, Domenico Caliendo, Vincenza Granata, Domenico Carbone, Maria Rosaria Muzio, Giuseppe Laurelli, Stefano Greggi, Francesca Falcone, Cira Antonietta Forte, Arturo Cuomo
Background: Anesthetic dreaming and anesthesia awareness are well distinct phenomena. Although the incidence of intraoperative awareness is more common among patients who reported a dream after surgery, the exact correlation between the two phenomena remains an unsolved rebus. The main purpose of this study was to investigate anesthetic dreaming, anesthesia awareness and psychological consequences eventually occurred under deep sedation. Intraoperative dreaming experiences were correlated with dream features in natural sleep...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104550/editorial-do-both-psychopathology-and-creativity-result-from-a-labile-wake-sleep-dream-cycle
#17
EDITORIAL
Sue Llewellyn, Martin Desseilles
No abstract text is available yet for this article.
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29102236/rem-sleep-behavior-disorder-portends-poor-prognosis-in-parkinson-s-disease-a-systematic-review
#18
REVIEW
Yoon Kim, Young Eun Kim, Eun Ok Park, Chae Won Shin, Han-Joon Kim, Beomseok Jeon
REM sleep behavior disorder (RBD) is a parasomnia wherein a loss of REM sleep atonia manifests as dream-enactment, often violent. Aside from its significance as a predictor of PD, RBD in PD may imply more than merely screaming at night and experiencing sleep fragmentation. To probe its significance as a prognostic factor in PD, we performed a systematic literature review. Analysis of prospective studies reveals baseline RBD confers a higher risk of developing dementia and hallucinations. In cross-sectional studies, RBD is associated with the non-tremor predominant motor phenotype and autonomic dysfunction...
October 25, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29101940/rem-sleep-behavior-disorder-diagnosis-clinical-implications-and-future-directions
#19
REVIEW
Erik K St Louis, Bradley F Boeve
Rapid eye movement sleep behavior disorder (RBD) is diagnosed by a clinical history of dream enactment accompanied by polysomnographic rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia). Rapid eye movement sleep behavior disorder is strongly associated with neurodegenerative disease, especially synucleinopathies such as Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. A history of RBD may begin several years to decades before onset of any clear daytime symptoms of motor, cognitive, or autonomic impairments, suggesting that RBD is the presenting manifestation of a neurodegenerative process...
November 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29098861/silicon-and-oxygen-s-bond-of-affection-an-acyclic-three-coordinate-silanone-and-its-transformation-to-an-iminosiloxysilylene
#20
Daniel Wendel, Dominik Reiter, Amelie Porzelt, Philipp J Altmann, Shigeyoshi Inoue, Bernhard Rieger
A long-term dream comes true: An acyclic, neutrally charged silanone at last! Here, we report on the first examples of isolable acyclic, neutral, three-coordinate silanones 2 with indefinite stability as solids and lifetimes in solution of up to two days. The electronic properties of the Si=O bond were investigated via DFT calculations and revealed the π‑donating N‑heterocyclic imino (NHI) and σ‑donating silyl groups as key factors for their enhanced stability. Besides initial reactivity studies of 2 towards CO2 and methanol, different isomerization pathways depending on the silyl substitution pattern were found...
November 3, 2017: Journal of the American Chemical Society
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