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https://www.readbyqxmd.com/read/29352748/use-of-e-learning-in-clinical-clerkships-effects-on-acquisition-of-dermatological-knowledge-and-learning-processes
#1
Frederike Fransen, Herm Martens, Ivo Nagtzaam, Sylvia Heeneman
Objectives: To obtain a deeper understanding of how the e-learning program, Education in Dermatology (ED), affects the acquisition of dermatological knowledge and the underlying learning processes of medical students in their clinical phase. Methods: The study used a mixed method design with a convergent parallel collection of data. Medical students (n=62) from Maastricht University (The Netherlands) were randomized to either a conventional teaching group (control group n=30) or conventional teaching plus the e-learning program (application on smartphone) group (e-learning group n=32)...
January 17, 2018: International Journal of Medical Education
https://www.readbyqxmd.com/read/29352695/truly-anatomic-coracoclavicular-ligament-reconstruction-with-2-endobutton-devices-for-acute-rockwood-type-v-acromioclavicular-joint-dislocations
#2
Cheng Xue, Li-Jun Song, Hao Zhang, Guo-Long Tang, Xiang Li, Jia-Hu Fang
BACKGROUND: Truly anatomic coracoclavicular ligament reconstruction (TACCR) according to the original insertions is a creative new method for the treatment of severe acromioclavicular separation. This research analyzed the clinical and radiologic results of TACCR in 25 patients with at least 2-year follow-up. METHODS: The study enrolled 25 patients with Rockwood type V acromioclavicular joint dislocations who underwent TACCR using 2 Endobutton (Smith & Nephew Inc...
January 15, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29352609/induction-of-mitophagy-in-the-hei-oc1-auditory-cell-line-and-activation-of-the-atg12-lc3-pathway-in-the-organ-of-corti
#3
Cristian Setz, Anne-Sophie Benischke, Anna Catharina Pinho Ferreira Bento, Yves Brand, Soledad Levano, Franziska Paech, Katharina Leitmeyer, Daniel Bodmer
Autophagy is a highly evolutionary conserved quality control defense mechanism within cells, which has also been implicated in cell death processes. In the mammalian inner ear, autophagy has been shown to play a role during early morphogenesis as well as in adult cochlear hair cells exposed to ototoxic insults. Mitophagy, a selective autophagic cell process targeting mitochondria, hasn't been studied in the inner ear so far. On this work, we searched for molecular indicators of mitophagy within House Ear Institute-Organ of Corti-1 (HEI-OC1) cells as well as in the organ of Corti (OC)...
January 11, 2018: Hearing Research
https://www.readbyqxmd.com/read/29352473/the-impact-of-mk-467-on-plasma-drug-concentrations-sedation-and-cardiopulmonary-changes-in-sheep-treated-with-intramuscular-medetomidine-and-atipamezole-for-reversal
#4
M Adam, M R Raekallio, T Keskitalo, J M Honkavaara, M Scheinin, M Kajula, S Mölsä, O M Vainio
The effect of MK-467, a peripheral α2 -adrenoceptor antagonist, on plasma drug concentrations, sedation and cardiopulmonary changes induced by intramuscular (IM) medetomidine was investigated in eight sheep. Additionally, the interactions with atipamezole (ATI) used for reversal were also evaluated. Each animal was treated four times in a randomized prospective crossover design with 2-week washout periods. Medetomidine (MED) 30 μg/kg alone or combined in the same syringe with MK-467 300 μg/kg (MMK) was injected intramuscular, followed by ATI 150 μg/kg (MED + ATI and MMK + ATI) or saline intramuscular 30 min later...
January 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29352472/the-bioequivalence-of-a-single-intravenous-administration-of-the-anesthetic-alfaxalone-in-cyclodextrin-versus-alfaxalone-in-cyclodextrin-plus-preservatives-in-cats
#5
K Pasloske, M G Ranasinghe, S Sauer, J Hare
To demonstrate the bioequivalence of alfaxalone in cyclodextrin (Reference Product) to a formulation of alfaxalone in cyclodextrin also containing the preservatives ethanol, chlorocresol, and benzethonium chloride (Test Product) when administered for the purpose of inducing anesthesia in the cat. Blinded, single-dose, randomized, two-period, two-sequence, cross-over bioequivalence study with a 7-day washout period between treatments. Twenty-four (12 neutered males and 12 intact females), healthy, adult cats weighing 4...
January 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29352454/decreased-opioid-consumption-and-enhance-recovery-with-the-addition-of-iv-acetaminophen-in-colorectal-patients-a-prospective-multi-institutional-randomized-double-blinded-placebo-controlled-study-dociva-study
#6
Amir H Aryaie, Sepehr Lalezari, Wallace K Sergent, Yana Puckett, Christopher Juergens, Craig Ratermann, Cari Ogg
BACKGROUND: We hypothesized that administration of IV acetaminophen alone would reduce the opioid consumption in post-operative colorectal surgery and reduce the side effects of narcotics. METHODS: Patients were randomized to receive either IV acetaminophen or placebo in addition to opioid PCA. Primary endpoints evaluated were opioid consumption and pain visual analogue scale score (PVASS) during first 48 h post-operatively. Secondary endpoints evaluated were time of return of GI function (ROGIF), time to diet ordered (TTDO), length of hospital stay (LOHS), and occurrence of ileus...
January 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29352416/point-of-care-ultrasound-in-pediatric-anesthesiology-and-critical-care-medicine
#7
REVIEW
Erik Su, Nicholas Dalesio, Aliaksei Pustavoitau
Ultrasound has increasingly become a clinical asset in the hands of the anesthesiologist and intensivist who cares for children. Though many applications for ultrasound parallel adult modalities, children as always are not simply small adults and benefit from the application of ultrasound to their management in various ways. Body composition and size are important factors that affect ultrasound performance in the child, as are the pathologies that may uniquely afflict children and aspects of procedures unique to this patient population...
January 19, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29352322/qportal-a-platform-for-data-driven-biomedical-research
#8
Christopher Mohr, Andreas Friedrich, David Wojnar, Erhan Kenar, Aydin Can Polatkan, Marius Cosmin Codrea, Stefan Czemmel, Oliver Kohlbacher, Sven Nahnsen
Modern biomedical research aims at drawing biological conclusions from large, highly complex biological datasets. It has become common practice to make extensive use of high-throughput technologies that produce big amounts of heterogeneous data. In addition to the ever-improving accuracy, methods are getting faster and cheaper, resulting in a steadily increasing need for scalable data management and easily accessible means of analysis. We present qPortal, a platform providing users with an intuitive way to manage and analyze quantitative biological data...
2018: PloS One
https://www.readbyqxmd.com/read/29352317/optic-flow-detection-is-not-influenced-by-visual-vestibular-congruency
#9
Vivian Holten, Paul R MacNeilage
Optic flow patterns generated by self-motion relative to the stationary environment result in congruent visual-vestibular self-motion signals. Incongruent signals can arise due to object motion, vestibular dysfunction, or artificial stimulation, which are less common. Hence, we are predominantly exposed to congruent rather than incongruent visual-vestibular stimulation. If the brain takes advantage of this probabilistic association, we expect observers to be more sensitive to visual optic flow that is congruent with ongoing vestibular stimulation...
2018: PloS One
https://www.readbyqxmd.com/read/29352299/bunyavirus-requirement-for-endosomal-k-reveals-new-roles-of-cellular-ion-channels-during-infection
#10
Samantha Hover, Becky Foster, Juan Fontana, Alain Kohl, Steve A N Goldstein, John N Barr, Jamel Mankouri
In order to multiply and cause disease a virus must transport its genome from outside the cell into the cytosol, most commonly achieved through the endocytic network. Endosomes transport virus particles to specific cellular destinations and viruses exploit the changing environment of maturing endocytic vesicles as triggers to mediate genome release. Previously we demonstrated that several bunyaviruses, which comprise the largest family of negative sense RNA viruses, require the activity of cellular potassium (K+) channels to cause productive infection...
January 19, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29352209/evaluating-street-view-exposure-measures-of-visible-green-space-for-health-research
#11
Andrew Larkin, Perry Hystad
Urban green space, or natural environments, are associated with multiple physical and mental health outcomes. Several proposed pathways of action for these benefits (e.g., stress reduction and attention restoration) require visual perception of green space; however, existing green space exposure measures commonly used in epidemiological studies do not capture street-scale exposures. We downloaded 254 Google Street View (GSV) panorama images from Portland, Oregon and calculated percent of green in each image, called Green View Index (GVI)...
January 19, 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29352163/word-mode-a-crowding-free-reading-protocol-for-individuals-with-macular-disease
#12
Stuart Wallis, Yit Yang, Stephen J Anderson
Central retinal loss through macular disease markedly reduces the ability to read largely because identification of a word using peripheral vision is negatively influenced by nearby text, a phenomenon termed visual crowding. Here, we present a novel peripheral reading protocol, termed Word Mode, that eliminates crowding by presenting each word in isolation but in a position that mimics its natural position in the line of text being read, with each new word elicited using a self-paced button press. We used a gaze-contingent paradigm to simulate a central scotoma in four normally-sighted observers, and measured oral reading speed for text positioned 7...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352155/conflict-sensitive-neurons-gate-interocular-suppression-in-human-visual-cortex
#13
Sucharit Katyal, Mark Vergeer, Sheng He, Bin He, Stephen A Engel
Neural suppression plays an important role in cortical function, including sensory, memory, and motor systems. It remains, however, relatively poorly understood. A paradigmatic case arises when conflicting images are presented to the two eyes. These images can compete for awareness, and one is usually strongly suppressed. The mechanisms that resolve such interocular conflict remain unclear. Suppression could arise solely from "winner-take-all" competition between neurons responsive to each eye. Alternatively, suppression could also depend upon neurons detecting interocular conflict...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352145/integrating-modality-specific-expectancies-for-the-deployment-of-spatial-attention
#14
Paola Mengotti, Frank Boers, Pascasie L Dombert, Gereon R Fink, Simone Vossel
The deployment of spatial attention is highly sensitive to stimulus predictability. Despite evidence for strong crossmodal links in spatial attentional systems, it remains to be elucidated how concurrent but divergent predictions for targets in different sensory modalities are integrated. In a series of behavioral studies, we investigated the processing of modality-specific expectancies using a multimodal cueing paradigm in which auditory cues predicted the location of visual or tactile targets with modality-specific cue predictability...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352131/early-impoverished-environment-delays-the-maturation-of-cerebral-cortex
#15
Roberta Narducci, Laura Baroncelli, Gabriele Sansevero, Tatjana Begenisic, Concetta Prontera, Alessandro Sale, Maria Cristina Cenni, Nicoletta Berardi, Lamberto Maffei
The influence of exposure to impoverished environments on brain development is unexplored since most studies investigated how environmental impoverishment affects adult brain. To shed light on the impact of early impoverishment on developmental trajectories of the nervous system, we developed a protocol of environmental impoverishment in which dams and pups lived from birth in a condition of reduced sensory-motor stimulation. Focusing on visual system, we measured two indexes of functional development, that is visual acuity, assessed by using Visual Evoked Potentials (VEPs), and VEP latency...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352107/mycolyltransferase-from-mycobacterium-tuberculosis-in-covalent-complex-with-tetrahydrolipstatin-provides-insights-into-antigen-85-catalysis
#16
Christopher M Goins, Steven Dajnowicz, Micholas D Smith, Jerry M Parks, Donald R Ronning
Mycobacterium tuberculosis Antigen 85 enzymes (Ag85s) catalyze the transfer of mycolic acid (MA) from trehalose monomycolate to produce the mycolyl arabinogalactan (mAG) or trehalose dimycolate (TDM). These lipids define the protective mycomembrane of Mycobacteria. The current model of substrate binding within the active sites of Ag85s for the production of TDM is not sterically and geometrically feasible; additionally, this model does not account for the production of mAG. Furthermore, this model does not address how Ag85s limit the hydrolysis of the acyl-enzyme intermediate while catalyzing acyl transfer...
January 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29352045/eliminating-glutamatergic-input-onto-horizontal-cells-changes-the-dynamic-range-and-receptive-field-organization-of-mouse-retinal-ganglion-cells
#17
Sebastian Ströh, Christian Puller, Sebastian Swirski, Maj-Britt Hölzel, Lea I S van der Linde, Jasmin Segelken, Konrad Schultz, Christoph Block, Hannah Monyer, Klaus Willecke, Reto Weiler, Martin Greschner, Ulrike Janssen-Bienhold, Karin Dedek
In the mammalian retina, horizontal cells receive glutamatergic inputs from many rod and cone photoreceptors and return feedback signals to them, thereby changing photoreceptor glutamate release in a light-dependent manner. Horizontal cells also provide feedforward signals to bipolar cells. It is unclear, however, how horizontal cell signals also affect the temporal, spatial and contrast tuning in retinal output neurons, the ganglion cells. To study this, we generated a genetically modified mouse line in which we eliminated the light dependency of feedback by deleting glutamate receptors from mouse horizontal cells...
January 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29351936/intravitreal-bevacizumab-for-postviral-fever-retinitis-a-novel-approach-for-early-resolution-of-macular-oedema
#18
Rohan Chawla, Dheepak M Sundar, Prasad Gupta, Kanhaiya Mittal
Severe macular oedema causing marked loss of vision is seen in cases of retinitis developing postviral fever. The use of antivascular endothelial growth factor agents for macular oedema and submacular fluid secondary to viral retinitis has not been studied or well established in the past. We report a case series of two patients of postviral retinitis with severe macular oedema resistant to steroid therapy, treated with intravitreal bevacizumab. The patients showed significant symptomatic improvement in the visual acuity...
January 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29351910/visual-literacy-in-bloom-using-bloom-s-taxonomy-to-support-visual-learning-skills
#19
Jessie B Arneson, Erika G Offerdahl
Vision and Change identifies science communication as one of the core competencies in undergraduate biology. Visual representations are an integral part of science communication, allowing ideas to be shared among and between scientists and the public. As such, development of scientific visual literacy should be a desired outcome of undergraduate instruction. We developed the Visualization Blooming Tool (VBT), an adaptation of Bloom's taxonomy specifically focused on visual representations, to aid instructors in designing instruction and assessments to target scientific visual literacy in undergraduate instruction...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29351863/size-congruity-influences-visual-search-via-the-target-template
#20
Kenith V Sobel, Amrita M Puri
In numerical comparison experiments, participants are presented with two digits that vary in numerical and physical size, and they select the numerically (or physically) larger (or smaller) of the two digits. Response times are typically faster when numerical and physical size are congruent than when they are incongruent, which is called the size congruity effect (SCE). Although numerical size is unlikely to be a guiding feature in visual search, recent studies have nevertheless observed the SCE in the visual search paradigm...
January 16, 2018: Acta Psychologica
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