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https://www.readbyqxmd.com/read/29150995/efficacy-and-safety-of-extracranial-vein-angioplasty-in-multiple-sclerosis-a-randomized-clinical-trial
#1
Paolo Zamboni, Luigi Tesio, Stefania Galimberti, Luca Massacesi, Fabrizio Salvi, Roberto D'Alessandro, Patrizia Cenni, Roberto Galeotti, Donato Papini, Roberto D'Amico, Silvana Simi, Maria Grazia Valsecchi, Graziella Filippini
Importance: Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by restricted venous outflow from the brain and spinal cord. Whether this condition is associated with multiple sclerosis (MS) and whether venous percutaneous transluminal angioplasty (PTA) is beneficial in persons with MS and CCSVI is controversial. Objective: To determine the efficacy and safety of venous PTA in patients with MS and CCSVI. Design, Setting, and Participants: We analyzed 177 patients with relapsing-remitting MS; 62 were ineligible, including 47 (26...
November 18, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29150982/visualization-within-the-ventricles-of-the-brain-a-micro-focus-x-ray-study
#2
Edwin John de Jager, André Francois du Plessis, Jakobus Willem Hoffman, Anna Catherina Oettlé, Marius Casparus Bosman
Conceptualization of the ventricular system of the brain by macroscopic studies is complicated by the lack of physical structure of these interconnected cavities. Dissection procedures designed to display the structures in the walls of the ventricles are destructive and not conducive for the appreciation of the ventricular system in its entirety. The application of Micro-focus X-ray tomography affords the possibility to appreciate hidden structures in a non-destructive manner. The aim of this study was to explore the possibility of using micro-focus X-ray tomography in the three-dimensional (3D) visualization of the ventricular system as well as the various neuroanatomical structures within its walls for educational purposes...
November 18, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29150814/detecting-multiple-random-changepoints-in-bayesian-piecewise-growth-mixture-models
#3
Eric F Lock, Nidhi Kohli, Maitreyee Bose
Piecewise growth mixture models are a flexible and useful class of methods for analyzing segmented trends in individual growth trajectory over time, where the individuals come from a mixture of two or more latent classes. These models allow each segment of the overall developmental process within each class to have a different functional form; examples include two linear phases of growth, or a quadratic phase followed by a linear phase. The changepoint (knot) is the time of transition from one developmental phase (segment) to another...
November 17, 2017: Psychometrika
https://www.readbyqxmd.com/read/29150685/visualizing-fate-changes
#4
Lei Lei
No abstract text is available yet for this article.
September 2017: Nature Plants
https://www.readbyqxmd.com/read/29150681/the-structure-function-relationship-measured-with-optical-coherence-tomography-and-a-microperimeter-with-auto-tracking-the-mp-3-in-patients-with-retinitis-pigmentosa
#5
Yuichi Asahina, Marie Kitano, Yohei Hashimoto, Mieko Yanagisawa, Hiroshi Murata, Tatsuya Inoue, Ryo Obata, Ryo Asaoka
The purpose of the current study was to investigate the structure-function relationship in patients with retinitis pigmentosa (RP) using optical coherence tomography and the MP-3 microperimeter. Visual field (VF) measurements were carried out using MP-3 microperimetry and the Humphrey Field Analyzer (HFA, Carl-Zeiss, CA), 22 eyes of 11 patients with a clinical diagnosis of RP, both with the 10-2 test grid pattern. Optical coherence tomography (OCT, Spectralis, Heidelberg, Germany) was also performed and the ellipsoid zone (EZ) was identified in the OCT image...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150640/early-endosome-motility-mediates-%C3%AE-amylase-production-and-cell-differentiation-in-aspergillus-oryzae
#6
Yusuke Togo, Yujiro Higuchi, Yoshinori Katakura, Kaoru Takegawa
Recent research in filamentous fungi has revealed that the motility of an endocytic organelle early endosome (EE) has a versatile role in many physiological functions. Here, to further examine the motility of EEs in the industrially important fungus Aspergillus oryzae, we visualized these organelles via the Rab5 homolog AoRab5 and identified AoHok1, a putative linker protein between an EE and a motor protein. The Aohok1 disruptant showed retarded mycelial growth and no EE motility, in addition to an apical accumulation of EEs and peroxisomes...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150624/semiquantative-visual-assessment-of-sub-solid-pulmonary-nodules-%C3%A2-3%C3%A2-cm-in-differentiation-of-lung-adenocarcinoma-spectrum
#7
Fu-Zong Wu, Po-An Chen, Carol C Wu, Pei-Lun Kuo, Shu-Ping Tsao, Chu-Chun Chien, En-Kuei Tang, Ming-Ting Wu
We aimed to analyze CT features of persistent subsolid nodules (SSN) ≦3 cm diagnosed pathologically as adenocarcinoma spectrum to investigate whether parameters enable distinction between invasive pulmonary adenocarcinomas (IPAs) and pre-invasive lesions. A total of 129 patients with 141 SSNs confirmed with surgically pathologic proof were retrospectively reviewed. Of 141 SSNs, there were 57 pure ground-glass nodules (GGNs), 22 heterogeneous GGNs, and 62 part-solid nodules. SSN subclassification showed a significant linear trend with invasive degree of the adenocarcinoma spectrum (pure GGNs 7%; heterogeneous GGNs 36...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150462/comprehensive-analysis-of-vitreous-specimens-for-uveitis-classification-a-prospective-multicentre-observational-study
#8
Kazuichi Maruyama, Tohru Inaba, Sunao Sugita, Ryo Ichinohasama, Kenji Nagata, Shigeru Kinoshita, Manabu Mochizuki, Toru Nakazawa
PURPOSE: To determine the clinical relevance of vitreous biomarkers in patients with uveitis. DESIGN: Multicentre, prospective, observational study. SETTING: Uveitis outpatient clinics of two academic medical centres in Japan. PATIENT POPULATION: This study included 234 eyes of 191 patients with various uveitis aetiologies: definitive sarcoidosis (61 eyes of 46 patients), suspected sarcoidosis (60 eyes of 45 patients), intraocular tumour (34 eyes of 27 patients), viral infection (20 eyes of 18 patients), non-sarcoidosis (16 eyes of 16 patients) and unknown aetiology (43 eyes of 39 patients)...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29150418/immune-enhancing-formulas-for-patients-with-cancer-undergoing-esophagectomy-systematic-review-protocol
#9
Astrid Naranjo, Elizabeth Isenring, Laisa Teleni
BACKGROUND: Adult patients with an esophageal cancer can potentially be compromised with postoperative leaks or fistulae if patients' nutritional status is in a vulnerable stage. Currently in Australia, there is a growing need for clinicians to know whether use of immune-enhancing formulas (IEFs) containing Arg, omega-3, and RNA are a cost-effective approach compared with isonitrogenous-isocaloric formulas to reduce postoperative infectious complications in esophagectomy patients. Since IEFs may carry higher costs, this has led to inconsistencies in practice among clinicians and hospitals...
November 17, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29150414/constraints-on-statistical-learning-across-species
#10
REVIEW
Chiara Santolin, Jenny R Saffran
Both human and nonhuman organisms are sensitive to statistical regularities in sensory inputs that support functions including communication, visual processing, and sequence learning. One of the issues faced by comparative research in this field is the lack of a comprehensive theory to explain the relevance of statistical learning across distinct ecological niches. In the current review we interpret cross-species research on statistical learning based on the perceptual and cognitive mechanisms that characterize the human and nonhuman models under investigation...
November 14, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/29150399/a-plate-waste-evaluation-of-the-farm-to-school-program
#11
Jaclyn D Kropp, Saul J Abarca-Orozco, Glenn D Israel, David C Diehl, Sebastian Galindo-Gonzalez, Lauren B Headrick, Karla P Shelnutt
OBJECTIVE: To investigate the impacts of the Farm to School (FTS) program on the selection and consumption of fruits and vegetables. DESIGN: Plate waste data were recorded using the visual inspection method before and after implementation of the program. SETTING: Six elementary schools in Florida: 3 treatment and 3 control schools. PARTICIPANTS: A total of 11,262 meal observations of National School Lunch Program (NSLP) participants in grades 1-5...
November 14, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29150380/comparison-of-two-physiotherapy-programmes-for-rehabilitation-after-temporomandibular-joint-arthroscopy
#12
W A Abboud, N Yarom, R Yahalom, M Joachim, S Reiter, O Koren, H Elishoov
The purpose of this study was to compare two physiotherapy programmes for rehabilitation after temporomandibular joint (TMJ) arthroscopy. The medical files of 137 consecutive patients diagnosed with closed lock and treated by arthroscopic lysis and lavage were analyzed retrospectively. Sixty-eight patients were rehabilitated with gradually increasing range of motion self-exercises (gradual programme) and 69 patients were rehabilitated with immediate full range of motion self-exercises (immediate programme)...
November 14, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29150363/development-of-a-3-french-dual-frequency-intravascular-ultrasound-catheter
#13
Chelsea E Munding, Emmanuel Chérin, Isaac Jourard, Jill J Weyers, David E Goertz, Brian K Courtney, F Stuart Foster
Coronary plaque morphology, including plaque size and fibrous cap thickness, is thought to contribute to the risk of plaque rupture and future cardiac events. Dual-frequency intravascular ultrasound has been proposed as a possible technique to visualize both large-scale features and superficial detail of coronary plaque; however, it has not been found to be feasible within the constraints of a clinically functional intravascular ultrasound catheter. In this study, we describe the design and fabrication of a dual-frequency catheter using a bidirectional transducer stack with center frequencies of approximately 30 and 80 MHz...
November 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29150357/caregiver-burden-of-parents-of-young-children-with-cystic-fibrosis
#14
C Fitzgerald, S George, R Somerville, B Linnane, P Fitzpatrick
BACKGROUND: There is a paucity of research examining the impact of informal caregiving on parents of young children with cystic fibrosis (CF). The aim of this study was to examine caregiver burden and identify risk factors associated with high caregiver burden in mothers and fathers of young children with CF. METHODS: This was a cross-sectional study of parents of young children with CF. A total of 213 families were invited to complete the CarerQoL questionnaire, a validated tool composed of two parts: (i) the CarerQol-7D which describes the care situation in terms of the negative and positive effects of caregiving and (ii) the visual analogue scale (VAS) which measures happiness on a scale from 0 to 10 (0=completely unhappy and 10=completely happy)...
November 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29150326/concomitant-mitral-valve-procedures-in-patients-undergoing-implantation-of-continuous-flow-left-ventricular-assist-devices-an-intermacs-database-analysis
#15
Jason O Robertson, David C Naftel, Susan L Myers, Ryan J Tedford, Susan M Joseph, James K Kirklin, Scott C Silvestry
BACKGROUND: Management of existing mitral valve (MV) disease in patients undergoing left ventricular assist device (LVAD) implantation remains controversial. METHODS: Among continuous-flow LVAD patients with moderate to severe mitral regurgitation entered into the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database between April 2008 and March 2014 (n = 4,930), outcomes were compared between patients who underwent MV repair (MVr, n = 252), MV replacement (MVR, n = 11) and no MV procedure (no MVP, n = 4,667)...
October 10, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29150217/idiopathic-macular-telangiectasia-type-2-prevalence-and-a-morphometric-and-phenotypic-study
#16
R M Bayón-Porras, I Pascual-Camps, C Plaza-Laguardia, R Gallego-Pinazo
OBJECTIVE: Type 2 idiopathic macular telangiectasia (MacTel2) is a rare retinal disease that has still not been well-defined. The aim of the present manuscript is to describe the clinical features by multimodal retinal imaging, to present the functional characteristics, and to estimate the prevalence of the disease. METHODS: A retrospective study was conducted on the 12 eyes of 6 patients with MacTel2. Fundus colour photographs, fundus autofluorescence, fluorescein angiography, optical coherence tomography (OCT), and OCT-angiography were performed and subsequently analysed...
November 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29150214/multifocal-best-s-disease-the-importance-of-genetic-tests
#17
C Alba Linero, M Rodríguez Calvo de Mora, M España Contreras, C Hernando Ayala
OBJECTIVES AND METHODS: Our objective is to describe a multifocal vitelliform presentation of Best's disease. The lesions in this disease may vary in size and shape, some may be a disc diameter in size, and often have some irregularity in their contour. The case is described of a 21-year-old male patient referred to our ophthalmology department due to a progressive loss of vision. His poor visual acuity was confirmed, and a complete examination was performed, in which macular flecks were observed, with yellow pigment arranged in oval distribution near their periphery...
November 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29150183/genetic-analysis-of-29-y-str-loci-in-the-chinese-han-population-from-shanghai
#18
Yuxiang Zhou, Chengchen Shao, Liming Li, Yaqi Zhang, Baonian Liu, Qinrui Yang, Qiqun Tang, Shilin Li, Jianhui Xie
The analysis of Y chromosomal short tandem repeats (Y-STRs) provides important information that can be used to forensic investigation and population studies. In this study, typing of 29 Y-STRs included in the PowerPlex(®) Y23 system (PPY23) and Yfiler™ Plus system (Yfiler plus) was performed on 843 unrelated male samples from Han population in Shanghai. Besides null, duplicate, and intermediate alleles reported in previous studies, an allele of 10 at DYS643 with a 2-base deletion in the flanking region was initially observed...
November 11, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29150140/visual-pathways-from-the-perspective-of-cost-functions-and-multi-task-deep-neural-networks
#19
REVIEW
H Steven Scholte, Max M Losch, Kandan Ramakrishnan, Edward H F de Haan, Sander M Bohte
Vision research has been shaped by the seminal insight that we can understand the higher-tier visual cortex from the perspective of multiple functional pathways with different goals. In this paper, we try to give a computational account of the functional organization of this system by reasoning from the perspective of multi-task deep neural networks. Machine learning has shown that tasks become easier to solve when they are decomposed into subtasks with their own cost function. We hypothesize that the visual system optimizes multiple cost functions of unrelated tasks and this causes the emergence of a ventral pathway dedicated to vision for perception, and a dorsal pathway dedicated to vision for action...
October 7, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29150139/visual-working-memory-performance-in-aphantasia
#20
Christianne Jacobs, Dietrich S Schwarzkopf, Juha Silvanto
Aphantasia, i.e., the congenital inability to experience voluntary mental imagery, offers a new model for studying the functional role of mental imagery in (visual) cognition. However, until now, there have been no studies investigating whether aphantasia can be linked to specific impairments in cognitive functioning. Here, we assess visual working memory performance in an aphantasic individual. We find that she performs significantly worse than controls on the most difficult (i.e., requiring the highest degree of precision) visual working memory trials...
November 8, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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