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https://www.readbyqxmd.com/read/29223124/activation-of-mitochondrial-katp-channels-mediates-neuroprotection-induced-by-chronic-morphine-preconditioning-in-hippocampal-ca-1-neurons-following-cerebral-ischemia
#1
Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Hamidreza Pazoki-Toroudi
PURPOSE: Pharmacologic preconditioning, through activating several mechanisms and mediators, can increase the tolerance of different tissues against ischemia/reperfusion (I/R) injury. Recent studies have shown that morphine preconditioning has protective effects in different organs, especially in the heart. Nevertheless, its mechanisms are not well elucidated in the brain. The present study aimed to clarify whether the activation of mitochondrial KATP (mKATP) channels in chronic morphine (CM) preconditioning could decrease hippocampus damage following I/R injury...
December 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29223110/systemic-inflammatory-markers-associated-with-cardiovascular-disease-and-acute-and-chronic-exposure-to-fine-particulate-matter-air-pollution-pm2-5-among-us-nhanes-adults-with-metabolic-syndrome
#2
Arvind Dabass, Evelyn O Talbott, Judith R Rager, Gary M Marsh, Arvind Venkat, Fernando Holguin, Ravi K Sharma
BACKGROUND: There has been no investigation to date of adults with metabolic syndrome examining the association of short and long-term exposure to fine particulate matter (PM2.5) air pollution with cardiovascular-disease related inflammatory marker (WBC and CRP) levels in a nationally representative sample. The goal of this study is to assess the susceptibility of adults with metabolic syndrome to PM2.5 exposure as suggested by increased cardiovascular-disease related inflammatory marker levels...
December 6, 2017: Environmental Research
https://www.readbyqxmd.com/read/29223100/activation-of-anti-oxidant-nrf2-signaling-by-enone-analogues-of-curcumin
#3
Lorraine M Deck, Lucy A Hunsaker, Thomas A Vander Jagt, Lisa J Whalen, Robert E Royer, David L Vander Jagt
Inflammation and oxidative stress are common in many chronic diseases. Targeting signaling pathways that contribute to these conditions may have therapeutic potential. The transcription factor Nrf2 is a major regulator of phase II detoxification and anti-oxidant genes as well as anti-inflammatory and neuroprotective genes. Nrf2 is widespread in the CNS and is recognized as an important regulator of brain inflammation. The natural product curcumin exhibits numerous biological activities including ability to induce the expression of Nrf2-dependent phase II and anti-oxidant enzymes...
November 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29223018/targeting-oxidant-dependent-mechanisms-for-the-treatment-of-respiratory-diseases-and-their-comorbidities
#4
REVIEW
Neil C Thomson
Oxidative stress is implicated in the pathogenesis of respiratory diseases, such as COPD and its comorbidities, asthma, idiopathic pulmonary fibrosis and radiation pneumonitis. Antioxidants drugs, such as small molecule thiols, nuclear erythroid-2 related factor 2 activators and catalytic enzyme mimetics have been developed to target oxidant-dependent mechanisms. The therapeutic effects of antioxidants have been generally disappointing. A small number of antioxidants are approved for clinical use, such as the small molecule thiol N-acetyl-l-cysteine for chronic obstructive pulmonary disease, and in the United States, the superoxide dismutase mimetic AEOL 10150 for severe radiation pneumonitis...
December 6, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29222997/-that-wasn-t-really-a-place-to-worry-about-diabetes-housing-access-and-diabetes-self-management-among-low-income-adults
#5
Danya E Keene, Monica Guo, Sascha Murillo
Lack of affordable housing access represents a significant and growing problem for low-income households in the United States and these housing challenges may present barriers to the management of chronic diseases such as type 2 diabetes. In this qualitative study, we examined how both housing challenges and housing resources shaped diabetes self-management behaviors. We conducted semi-structured interviews with 40 low-income residents of one US city, New Haven, Connecticut, who had a diagnosis of type 2 diabetes and either resided in or qualified for subsidized housing...
December 2, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29222991/salivary-immune-proteins-monitoring-can-help-detection-of-binge-and-chronic-alcohol-drinkers-preliminary-findings
#6
Napoleon Waszkiewicz, Beata Galińska-Skok, Anna Zalewska, Sławomir Dariusz Szajda, Krzysztof Zwierz, Magdalena Więdłocha, Agata Szulc
BACKGROUND: We compared effects of binge and chronic alcohol drinking on oral health and salivary immunity proteins. METHODS: The study involved males: 13 healthy social-drinking (C), 10 alcohol-dependent after chronic alcohol-intoxication (A), and 8 binge-drinkers after a single binge-drinking session (B). We compared periodontal/dental state and salivary immune proteins (lactoferrin -Lf, lysozyme -Lz, oral peroxidase -OPO, immunoglobulin A -IgA) in all groups...
December 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29222988/medically-unexplained-physical-symptoms-in-patients-attending-a-medical-outpatient-clinic-in-a-tertiary-hospital-in-north-india
#7
Mohit Sharma, Shubh Mohan Singh, Ajit Avasthi, Subhash C Varma, Aman Sharma, Vikas Suri
OBJECTIVE: Medically unexplained physical symptoms (MUPS) are commonly seen across health care settings. Earlier studies have focussed on prevalence, cost-utilization and burden. Data from India is scarce. Patients with persistent MUPS have more impairment and psychological distress. This study was designed to assess psychological morbidity, health anxiety (HA), somatic symptom load, disability, quality of life (QOL) in patients with persistent MUPS presenting to a general medical outpatient service and compare it with patients with medically explained physical symptoms (MEPS)...
December 2, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29222987/frequency-and-correlates-of-tardive-dyskinesia-in-indian-patients-with-type-i-bipolar-disorder
#8
Tess Maria Rajan, Balaji Bharadwaj, Ravi Philip Rajkumar, Prashant Shankarrao Adole
BACKGROUND: Patients with Bipolar Disorder (BD) may have higher risk of Tardive Dyskinesia (TD). Theories for TD include inflammatory or oxidative stress and altered iron metabolism. The current frequency and clinical and biochemical correlates of TD in BD needs exploration. OBJECTIVES: To assess: (1) the frequency of TD in BD; (2) clinical correlates of TD in BD; (3) oxidative stress markers, inflammatory markers and hepcidin in TD in BD. MATERIALS & METHODS: In this cross-sectional study, 170 patients with BD were assessed for clinical characteristics using structured assessments...
December 5, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29222982/association-between-mthfr-variant-and-diabetic-neuropathy
#9
Armita Kakavand Hamidi, Mania Radfar, Mahsa M Amoli
BACKGROUND: Methylene-tetrahydrofolate reductase (MTHFR) gene variant may play an important role in the pathophysiology of diabetes and its complications due to its influence on plasma homocysteine levels and also its effect on scavenging peroxynitrite radicals. Diabetic peripheral neuropathy (DPN) is one of the most common diabetic chronic complications. The aim of this study was to investigate the relationship between diabetic neuropathy and MTHFR gene C677T and 1298A ⁄C polymorphisms...
April 26, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29222944/cerebral-microbleeds-an-mri-review-of-common-and-less-common-causes
#10
REVIEW
Dimitri Renard
Cerebral microbleeds (CMB) are small foci of (acute, subacute, or chronic) blood products, best seen using MRI techniques sensitive to iron deposits (i.e. gradient-echo T2*-weighted and susceptibility-weighted imaging), frequently encountered in small vessel disease (SVD, with hypertensive vasculopathy and cerebral amyloid angiopathy as most frequent conditions) and also in other disorders. In this review, we will mainly discuss the MRI characteristics of CMB and the associated MRI abnormalities encountered in common and less common SVD and non-SVD conditions...
December 9, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29222936/role-of-central-oxytocin-and-dopamine-systems-in-nociception-and-their-possible-interactions-suggested-hypotheses
#11
Mohammed Gamal-Eltrabily, Alfredo Manzano-García
Central oxytocin and dopamine have an important role in the process of nociception at the spinal level as well as supraspinal structures, e.g. anterior cingulate cortex, insular cortex, amygdala, nucleus accumbens, and hypothalamus. Many studies have pointed out the importance of both systems in the pain descending modulatory system and in pain-related symptoms in some chronic disorders, e.g. Parkinson disease and fibromyalgia. The interaction between oxytocin and dopamine systems has been addressed in some motivational behaviors, e...
December 9, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29222926/depressive-personality-vulnerability-in-chronic-physical-pain-centrality-of-sociotropy
#12
Golan Shahar, Sheera F Lerman, Maayan Topaz, Silviu Brill, Hadar Shalev, Zvia Rudich
BACKGROUND: Chronic physical pain is one of modern medicine's principal challenges. Recently, there has been a keen research interest in the role of Depressive Personality Vulnerability (DPV) in the course of chronic pain. OBJECTIVE: This is the first attempt to examine the role of three leading DPV dimensions - sociotropy, autonomy, and self-criticism - in chronic pain. METHOD: Chronic pain patients (N = 428) were assessed four times as to their pain, disability, anxious-depression, and pain-based catastrophizing...
December 9, 2017: Journal of Personality
https://www.readbyqxmd.com/read/29222885/chronic-low-grade-inflammation-measured-by-dietary-inflammatory-index-and-its-association-with-obesity-among-school-teachers-in-yangon-myanmar
#13
Khin Mittar Moe San, Umi Fahmida, Fiastuti Wijaksono, Htin Lin, Ko Ko Zaw, Min Kyaw Htet
BACKGROUND AND OBJECTIVES: This study was aimed to investigate the association between obesity and chronic low grade inflammation (CLGI) measured by Dietary Inflammatory Index (DII) as a proxy indicator of CLGI among obese and non-obese teachers. METHODS AND STUDY DESIGN: We conducted a cross sectional study among 128 non-obese (BMI <25) and 116 obese (BMI >=25) female teachers aged 25-60 years from six urban schools in Yangon, Myanmar between January and March 2015...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222878/non-communicable-diseases-food-and-nutrition-in-vietnam-from-1975-to-2015-the-burden-and-national-response
#14
Tuan T Nguyen, Minh V Hoang
BACKGROUND AND OBJECTIVES: This review manuscript examines the burden and national response to non-communicable diseases (NCDs), food and nutrition security in Vietnam from 1975 to 2015. METHODS AND STUDY DESIGN: We extracted data from peer-reviewed manuscripts and reports of nationally representative surveys and related policies in Vietnam. RESULTS: In 2010, NCDs accounted for 318,000 deaths (72% of total deaths), 6.7 million years of life lost, and 14 million disability-adjusted life years in Vietnam...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222851/convergent-validity-of-the-dutch-central-sensitization-inventory-associations-with-psychophysical-pain-measures-quality-of-life-disability-and-pain-cognitions-in-patients-with-chronic-spinal-pain
#15
Jeroen Kregel, Charline Schumacher, Mieke Dolphens, Anneleen Malfliet, Dorien Goubert, Dorine Lenoir, Barbara Cagnie, Mira Meeus, I Coppieters
OBJECTIVE: Symptoms of Central Sensitization (CS) have been described in patients with chronic spinal pain (CSP). Although a gold standard to diagnose CS is lacking, psychophysical pain measures are often used. The Central Sensitization Inventory (CSI) is proposed as an alternative method and indirect tool for evaluation of CS symptomatology. The aim of the current study was to evaluate the convergent validity of the CSI by investigating the association with psychophysical pain measures and self-reported measures of current pain intensity, quality of life, disability, and catastrophizing in CSP patients...
December 8, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29222812/spheroid-type-of-al-amyloid-deposition-associated-with-colonic-adenocarcinoma-a-case-report-with-literature-review
#16
Moon Joo Kim, Zulfia McCroskey, Yingchao Piao, Anna Belcheva, Luan Truong, Paul J Kurtin, Jae Y Ro
We report a colonic adenocarcinoma associated with diffuse submucosal deposition of a peculiar spheroid-type amyloid identified in the colon, terminal ileum, and appendix. A 65-year-old woman with past medical histories of hypertension, and chronic obstructive pulmonary disease, presented to the emergency room with cramping abdominal pain and nausea. A computed tomography (CT) scan of abdomen showed right colonic volvulus. Emergency right hemicolectomy was performed. The specimen showed colonic adenocarcinoma with focal submucosal invasion (pT1) arising from a villotubular adenoma...
December 8, 2017: Pathology International
https://www.readbyqxmd.com/read/29222794/active-induction-of-experimental-autoimmune-encephalomyelitis-in-c57bl-6-mice
#17
Gabriella Contarini, Pietro Giusti, Stephen D Skaper
The protocol in this chapter presents a method to actively induce experimental autoimmune encephalomyelitis (EAE), one of the most widely used animal models to study efficacy of potential drugs for treatment of multiple sclerosis. Multiple sclerosis is an inflammatory, demyelinating disease of the central nervous system and the most common cause of chronic neurological impairment in young people. In this model EAE is induced in female C57BL/6 mice by immunization with an emulsion of myelin oligodendrocyte glycoprotein (fragment 35-55) in complete Freund's adjuvant, followed by administration of pertussis toxin in phosphate-buffered saline...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222781/cell-enumeration-assays-application-of-the-mtt-and-sulforhodamine-b-assays-to-lipopolysaccharide-stimulated-neonatal-rodent-microglia
#18
Laura Facci, Stephen D Skaper
Glial cell activation, in particular microglia, plays an important role in the pathogenesis of various neurodegenerative disorders as well as in chronic and neuropathic pain. This chapter compares two established cell enumeration assays, namely, the colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay and the protein-binding sulforhodamine B assay for microglia as a function of culture condition and activation state. The pros and cons of each are then described.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222778/astrocyte-microglia-cocultures-as-a-model-to-study-neuroinflammation
#19
Laura Facci, Massimo Barbierato, Stephen D Skaper
Glial cell activation plays an important role in the pathogenesis of various neurodegenerative disorders as well as in chronic and neuropathic pain. This chapter describes a model which allows one to assess the individual and combined contributions of astrocytes and microglia in response to a pro-inflammatory stimulus, with emphasis on ionotropic purinergic receptors.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222767/platelet-counts-and-liver-enzymes-after-gastric-bypass-surgery
#20
Hans-Erik Johansson, Anna Wåhlén, Erica Aldenbäck, Arvo Haenni
BACKGROUND: Obesity is associated with chronic inflammation, liver steatosis and increased liver enzymes such as gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for non-alcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are a biomarker reflecting inflammation and the degree of fibrosis in NAFLD. We investigated alterations in PCs, GGT, ALT, C-reactive protein (CRP) and ferritin after Roux-en-Y gastric bypass (RYGBP)...
December 8, 2017: Obesity Surgery
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