keyword
MENU ▼
Read by QxMD icon Read
search

Chronic

keyword
https://www.readbyqxmd.com/read/29913483/the-associations-between-the-growth-hormone-insulin-like-growth-factor-1-axis-adiponectin-resistin-and-metabolic-profile-in-children-with-growth-hormone-deficiency-before-and-during-growth-hormone-treatment
#1
Ewelina Witkowska-Sędek, Małgorzata Rumińska, Anna Stelmaszczyk-Emmel, Anna Majcher, Beata Pyrżak
This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913451/progression-of-chronic-kidney-disease-affects-hdl-impact-on-lipoprotein-lipase-lpl-mediated-vldl-lipolysis-efficiency
#2
Agnieska Ćwiklińska, Monika Cackowska, Ewa Wieczorek, Ewa Król, Robert Kowalski, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwińska, Kamil Dąbkowski, Justyna Zielińska, Alicja Dębska-Ślizień, Maciej Jankowski
BACKGROUND/AIMS: Hypertriglyceridaemia (HTG) and reduction and dysfunction of high density lipoprotein (HDL) are common lipid disturbances in chronic kidney disease (CKD). HTG in CKD is caused mainly by the decreased efficiency of lipoprotein lipase (LPL)-mediated very low density lipoprotein triglyceride (VLDL-TG) lipolysis. It has not been clarified whether HDL dysfunction in CKD contributes directly to HTG development; thus, the aim of this study was to assess the impact of CKD progression on the ability of HDL to enhance LPL-mediated VLDL-TG lipolysis efficiency...
June 15, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29913442/associations-of-pulmonary-fibrosis-with-peripheral-blood-th1-th2-cell-imbalance-and-ebf3-gene-methylation-in-uygur-pigeon-breeder-s-lung-patients
#3
Chao Wu, Zujin Luo, Baosen Pang, Wenyi Wang, Mingqin Deng, Rong Jin, Xirennayi Muhataer, Yafang Li, Qifeng Li, Xiaohong Yang
Background/Aims Pigeon breeder's lung (PBL) results from Th1/Th2 cell imbalance. B cells inhibit the immune activity of Th1, and EBF3 is a key B cell factor. This study explored the relationship between EBF3 and Th1/Th2 imbalance in chronic PBL cases complicated with pulmonary fibrosis (PF). Methods Twenty Uygur PBL+PF patients, 20 pigeon breeders without PBL or PF, and 20 healthy individuals without pigeon breeding history constituted the patient I, negative control, and normal control groups, respectively...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913407/the-effect-of-dichloroacetate-in-mouse-models-of-epilepsy
#4
Dylan Durie, Tanya S McDonald, Karin Borges
A recent report has found that glucose oxidation and the activity of pyruvate dehydrogenase (PDH) are reduced in the chronic stage of the pilocarpine mouse epilepsy model. This is likely caused by increased phosphorylation by PDH kinase of the E1α subunit of PDH, downregulating its activity. Inhibition of this phosphorylation has not yet been explored as a possible approach to treat epilepsy. Chronic dichloroacetate (DCA, 50 and 100 mg/kg/day) treatment was tested in acute seizure and the chronic pilocarpine models...
June 15, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29913390/orexin-a-prevents-degradation-of-the-articular-matrixes-in-human-primary-chondrocyte-culture
#5
Dong Wang, Hui Ren, Chunlong Li, Fanghe Liu, Guangzhi Wang, Fengjun Shi, Yuanxin Sun
Excessive production of pro-inflammatory cytokines such as interleukin-1β (IL-1β) plays a key role in the pathophysiological development of osteoarthritis (OA). Orexin A is an important peptide of hypothalamic origin, which has displayed its multiple biological functions in several chronic diseases via activation of its specific G-protein coupled receptors, orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R). In this study, we aimed to characterize the protective effects of orexin A against IL-1β-induced degradation of articular cartilage matrixes in human chondrocytes...
June 15, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29913350/nt-probnp-is-a-potential-mediator-between-reduced-ejection-fraction-and-depression-in-patients-with-heart-failure
#6
Pedro Zuzarte, Gustavo Scola, Angela Duong, Kari Kostiw, Maria L Figueira, Atilio Costa-Vitali
Depression and anxiety are prevalent in patients with heart failure (HF). Reduced ejection fraction (EF) and increased N-terminal-prohormone B-type natriuretic peptide (NT-proBNP) have been shown to be independently associated with depressive symptoms and may therefore increase HF disease progression and mortality. This study evaluated whether NT-proBNP mediated the impact of reduced EF on depressive and anxiety symptoms in patients with HF. Participants (n = 124) were patients with a diagnosis of chronic HF enrolled in the Heart Failure Disease Management Program at Health Sciences North...
June 9, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29913272/sirna-lipopolymer-nanoparticles-to-arrest-growth-of-chronic-myeloid-leukemia-cells-in-vitro-and-in-vivo
#7
Juliana Valencia-Serna, Hamidreza M Aliabadi, Adam Manfrin, Mahsa Mohseni, Xiaoyan Jiang, Hasan Uludag
Therapies for the treatment of Chronic Myeloid Leukemia and other leukemias are still limited for patients at advanced stages, which allow development of point mutations in the BCR-ABL fusion gene that render CML cells insensitive to therapies. An effective non-viral delivery system based on lipopolymers is described in this study to deliver specific siRNAs to CML cells for therapeutic gene silencing. The lipopolymer, based on the lipid α-linolenic acid (αLA) substitution on low molecular weight polyethyleneimine (PEI), was used to deliver siRNA against the BCR-ABL gene and, the resultant therapeutic effect was evaluated in in vitro and in vivo CML models...
June 15, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29913243/spinal-inhibition-of-p2xr-or-p38-signaling-disrupts-hyperalgesic-priming-in-male-but-not-female-mice
#8
Candler Paige, Gayathri Batchalli Maruthy, Galo Mejia, Gregory Dussor, Theodore Price
Recent studies have demonstrated sexual dimorphisms in the mechanisms contributing to the development of chronic pain. Here we tested the hypothesis that microglia might preferentially regulate hyperalgesic priming in male mice. We based this hypothesis on evidence that microglia preferentially contribute to neuropathic pain in male mice via ionotropic purinergic receptor (P2XR) or p38 mitogen activated protein kinase (p38) signaling. Mice given a single priming injection of the soluble human interleukin-6 receptor (IL-6r) and then a second injection of prostaglandin E2 (PGE2 ), which unmasks hyperalgesic priming, show a significant increase in levels of activated microglia at 3h following the PGE2 injection in both male and female mice...
June 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29913232/genotoxic-alkenylbenzene-flavourings-a-contribution-to-risk-assessment
#9
Célia Martins, José Rueff, António S Rodrigues
Alkenylbenzenes, such as estragole, myristicin and eugenol, are present is several flavourings, functional foods, plant food supplements (PFS) and in complementary and alternative medicines (CAM) including herbal medicines. The increase in consumption in functional foods observed worldwide requires a strict analysis of the scientific validity of their benefits and risk-benefit ratio associated with their intake. Some instances of acute toxicity have been reported associated with the use of herbal medicines and PFS, in particular because quality control is poor, and this poses a risk especially in internet marketed products...
June 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29913204/phenotypic-identification-of-periodontal-prevotella-intermedia-nigrescens-group-isolates-validated-by-maldi-tof-mass-spectrometry
#10
Thomas E Rams, Jacqueline D Sautter, Chinhua Y Hsiao, Arie J van Winkelhoff
The accuracy of a phenotypic scheme to recognize periodontal Prevotella intermedia/nigrescens group clinical isolates on primary isolation culture plates was assessed with matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS). A total of 84 fresh subgingival isolates from 23 chronic periodontitis patients were presumptively recognized on anaerobically-incubated enriched Brucella blood agar primary isolation plates as P. intermedia/nigrescens based on their dark-pigmented colony morphology, brick-red autofluorescence under long-wave ultraviolet light, and a negative fluorescence test for lactose production...
June 15, 2018: Anaerobe
https://www.readbyqxmd.com/read/29913190/neurochemical-changes-underlying-schizophrenia-related-behavior-in-a-modified-forced-swim-test-in-mice
#11
Monika Wożniak, Paulina Cieślik, Marcin Marciniak, Tomasz Lenda, Andrzej Pilc, Joanna M Wieronska
The modified forced swim test (MFST) has excellent predictive validity for investigating the antipsychotic activity of drugs, with particular emphasis on their activity toward negative symptoms of schizophrenia. However, its face and construct validity are less understood. Therefore, in the present study, some biochemical changes within GABAergic and serotonergic neurotransmission that could be related to observed MK-801-induced disturbances and the activity of compounds active at those neurotransmitters were investigated...
June 15, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29913183/predictive-metabolic-signatures-of-end-stage-renal-disease-a-multivariate-analysis-of-population-based-data
#12
Robson E Silva, João L Baldim, Daniela A Chagas-Paula, Marisi G Soares, João H G Lago, Reggiani V Gonçalves, Rômulo D Novaes
The variability of molecular signatures and predictive low molecular weight markers of chronic kidney disease (CKD) in different populations are poorly understood. Thus, in a large sample with 4763 people we compare the molecular signatures and metabolites with diagnostic relevance in plasma and urine of CKD patients of different geographical origins. From an integrated model based on dynamic networks and multivariate statistics, metabolites with predictive value obtained from targeted and untargeted molecular analysis, interactions between metabolic pathways affected by CKD, and the methodological quality of metabolomic studies were analyzed...
June 15, 2018: Biochimie
https://www.readbyqxmd.com/read/29913178/deficiency-of-adenosine-deaminase-2-special-focus-on-central-nervous-system-imaging
#13
Elif Bulut, Abdulsamet Erden, Omer Karadag, Kader Karli Oguz, Seza Ozen
PURPOSE: To increase the knowledge of central nervous system (CNS) imaging features in deficiency of adenosine deaminase 2 (DADA2) by examining magnetic resonance imaging (MRI) studies of a relatively large number of patients. METHODS: We retrospectively examined neuroimages of 12 patients (7 male, 5 female) diagnosed with DADA2. The mean age of the patients at the time of initial brain MRI was 16.7±10.2 years. Seven patients (58.3%) fulfilled the classification criteria of polyarteritis nodosa...
June 15, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29913135/chronic-abdominal-pain-in-a-47-year-old-woman
#14
Bradley Anderson, Seth Sweetser
No abstract text is available yet for this article.
June 15, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29913125/effect-of-co-administration-of-two-different-phosphodiesterase-inhibitors-and-a-%C3%AE-3-adrenoceptor-agonist-in-an-experimental-model-of-detrusor-overactivity
#15
Bruno Lima Linhares, Nilberto Robson Falcão Nascimento, Lúcio Flávio Gonzaga-Silva, Cláudia Ferreira Santos, Manoel Odorico Moraes, Lucas Bernardo Marinho, Ana Patrícia Gonçalves Silva, Manassés Claudino Fonteles, Ricardo Reges
The purpose of this study was to evaluate in vitro the effect of the combination of BRL 37344 (ß3 -adrenoceptor agonist) with tadalafil (phosphodiesterase type 5 inhibitor) or rolipram (phosphodiesterase type 4 inhibitor) in an experimental model of detrusor overactivity. The experiments were carried out in two phases using bladder strips of mice. In the first phase, on the top of 40mM potassium-induced contraction, strips isolated from control mice were exposed to increasing concentrations of each study drug...
June 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29913079/long-term-management-of-parkinson-s-disease-using-levodopa-combinations
#16
Thomas Müller, Jan-Dominique Möhr
Parkinson's disease is a chronic, neurodegenerative disease. Its symptoms and course are heterogeneous. After several years of investigative drug studies, levodopa remains the most efficacious drug despite its long-term limitations. Consequently, research into new drug delivery modes is ongoing. Areas covered: This review summarizes past and current advances of levodopa therapy with a focus on long-term patient management. Current research aims to increase drug bioavailability and to deliver it to the brain continuously...
June 18, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29913077/higher-exosomal-tau-amyloid-beta-42-and-il-10-are-associated-with-mild-tbis-and-chronic-symptoms-in-military-personnel
#17
Jessica Gill, Maja Mustapic, Ramon Diaz-Arrastia, Rael Lange, Seema Gulyani, Tom Diehl, Vida Motamedi, Nicole Osier, Robert A Stern, Dimitrios Kapogiannis
OBJECTIVE: Identify biomarkers in peripheral blood that relate to chronic post-concussive and behavioural symptoms following traumatic brain injuries (TBIs) to ultimately improve clinical management. RESEARCH DESIGN: We compared military personnel with mild TBIs (mTBIs) (n = 42) to those without TBIs (n = 22) in concentrations of tau, amyloid-beta (Aβ42) and cytokines (tumour necrosis factor alpha (TNFα, interleukin (IL)-6 and -10) in neuronal-derived exosomes from the peripheral blood...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29912967/patients-perceptions-of-their-experiences-with-nurse-patient-communication-in-oncology-settings-a-focused-ethnographic-study
#18
Engle Angela Chan, Fiona Wong, Man Yin Cheung, Winsome Lam
BACKGROUND: The nursing shortage and its impact on patient care are well-documented global issues. Patients living with cancer as a chronic illness have many psychosocial problems and often lack adequate support as a result of ineffective nurse-patient communication. A review of the literature on factors influencing the delivery of psychosocial care to cancer patients indicates that the delivery of psychosocial care in routine cancer nursing within a biomedical healthcare system has not been widely explored...
2018: PloS One
https://www.readbyqxmd.com/read/29912880/investigating-the-association-of-ventral-and-dorsal-striatal-dysfunction-during-reward-anticipation-with-negative-symptoms-in-patients-with-schizophrenia-and-healthy-individuals
#19
Marta Stepien, Andrei Manoliu, Roman Kubli, Karoline Schneider, Philippe N Tobler, Erich Seifritz, Marcus Herdener, Stefan Kaiser, Matthias Kirschner
BACKGROUND: Negative symptoms are a core feature of schizophrenia and also found in healthy individuals in subclinical forms. According to the current literature the two negative symptom domains, apathy and diminished expression may have different underlying neural mechanisms. Previous observations suggest that striatal dysfunction is associated with apathy in schizophrenia. However, it is unclear whether apathy is specifically related to ventral or dorsal striatal alterations. Here, we investigated striatal dysfunction during reward anticipation in patients with schizophrenia and a non-clinical population, to determine whether it is associated with apathy...
2018: PloS One
https://www.readbyqxmd.com/read/29912860/chronic-stress-associated-visceral-hyperalgesia-correlates-with-severity-of-intestinal-barrier-dysfunction
#20
Amy L Creekmore, Shuangsong Hong, Shengtao Zhu, Jing Xue, John W Wiley
In humans, chronic psychological stress is associated with increased intestinal paracellular permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent water avoidance stress (WAS) rat model. However, it is unknown whether enhanced visceral pain and permeability are intrinsically linked and correlate. Treatment of rats with lubiprostone during WAS significantly reduced WAS-induced changes in intestinal epithelial paracellular permeability and visceral hyperalgesia in a subpopulation of rats...
April 30, 2018: Pain
keyword
keyword
2460
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"