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https://www.readbyqxmd.com/read/29244607/a-survey-of-risk-factors-for-digit-injuries-among-dogs-training-and-competing-in-agility-events
#1
Debra C Sellon, Katherine Martucci, John R Wenz, Denis J Marcellin-Little, Michelle Powers, Kimberley L Cullen
OBJECTIVE To identify potential risk factors for digit injuries in dogs training and competing in agility events. DESIGN Internet-based, retrospective, cross-sectional survey. ANIMALS 1,081 dogs training or competing in agility events. PROCEDURES Data were collected for eligible animals via retrospective surveys distributed electronically to handlers of dogs participating in agility-related activities. Variables evaluated included demographic (handlers) and signalment (dogs) information, physical characteristics of dogs, and injury characteristics...
January 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29243659/comparative-study-of-the-serum-measurement-of-pth-on-roche-cobas-e411%C3%A2-versus-the-abbott-architect-ci8200%C3%A2
#2
Mohammed Bensalah, Ouardia Bouayadi, Nawal Rahmani, Amina Lyagoubi, Somiya Lamrabat, Mohammed Choukri
Parathormone (PTH) is the main hormone of phosphocalcic homeostasis. It is synthesized and secreted by the parathyroid glands. PTH has become a routine test in the medical biology laboratory. However, its measurement presents analytical difficulties with the various marketed kits. The aim of this work is to present the results of a comparative study between the PTH measurment on Abbott architect ci8200 and on Roche's Cobas e411 automaton. It is a prospective study carried out for 252 hospitalized patients in the various departments of the University Hospital Center Mohammed VI of Oujda...
December 15, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29243101/fractures-in-a-nationwide-population-based-cohort-of-users-of-breast-cancer-hormonal-therapy
#3
Joan M Neuner, Yushu Shi, Amanda L Kong, Sailaja Kamaraju, Elizabeth C Smith, Alicia J Smallwood, Purushottam W Laud, John A Charlson
PURPOSE: Although users of aromatase inhibitors have higher total fracture risk in some randomized trials, little is known about their risk outside of clinical trials or in older higher-risk cohorts. METHODS: In a population-based retrospective cohort study, we identified all older US Medicare D prescription drug insurance plan-enrolled women who had initial breast cancer surgery in 2006-2008 and began hormonal therapy (an aromatase inhibitor (AI) or tamoxifen) within the subsequent year...
December 15, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29242986/pre-and-postconditioning-the-heart-with-hydrogen-sulfide-h2s-against-ischemia-reperfusion-injury-in-vivo-a-systematic-review-and-meta-analysis
#4
REVIEW
Qutuba G Karwi, Justin S Bice, Gary F Baxter
Conditioning-like infarct limitation by enhanced level of hydrogen sulfide (H2S) has been demonstrated in many animal models of myocardial ischemia/reperfusion injury (MIRI) in vivo. We sought to evaluate the effect of H2S on myocardial infarction across in vivo pre-clinical studies of MIRI using a comprehensive systematic review followed by meta-analysis. Embase, Pubmed and Web of Science were searched for pre-clinical investigation of the effect of H2S on MIRI in vivo. Retained records (6031) were subjected to our pre-defined inclusion criteria then were objectively critiqued...
December 14, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29242070/anesthetic-type-and-hospital-outcomes-after-carotid-endarterectomy-from-the-vascular-quality-initiative-database
#5
Hanaa Dakour Aridi, Nawar Paracha, Besma Nejim, Satinderjit Locham, Mahmoud B Malas
OBJECTIVE: Studies on the safety of carotid endarterectomy (CEA) under different anesthetic techniques are sometimes contradictory. The aim of this study was to compare real-world outcomes of CEA under general anesthesia (GA) vs regional or local anesthesia (RA/LA). METHODS: A retrospective analysis of the Vascular Quality Initiative database (2003-2017) was performed. Primary outcomes included perioperative stroke, death, and myocardial infarction (MI) occurring during the hospital stay...
December 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29241902/scientific-evidence-in-health-technology-assessment-reports-an-in-depth-analysis-of-european-assessments-on-high-risk-medical-devices
#6
Britta Olberg, Sabine Fuchs, Dimitra Panteli, Matthias Perleth, Reinhard Busse
BACKGROUND: The aim of this study was to examine the scientific evidence on clinical effectiveness and safety used in health technology assessments (HTAs) of high-risk medical devices (MDs) in Europe. METHODS: We applied a systematic approach to identify European institutions involved in HTA and to select reports assessing MDs considered high-risk according to the definition in the new German health care regulation §137h. Reports published between 2010 and 2015 were considered in our subsequent analysis...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29240453/medical-students-implicit-bias-and-the-communication-of-norms-in-medical-education
#7
Rachael Hernandez
ISSUE: Medical educators should consider how institutional norms influence medical students' perceptions of implicit bias. Understanding normative structures in medical education can shed light on why this influence is associated with students' resistance to implicit bias. EVIDENCE: Extant research across diverse fields of study uncovers and theorizes layers of norms and normative systems and how they are related to ethical behavior. This review bridges the fields of communication, bioethics, and medical education, constructing an organized foundation and common language by which researchers can build effective educational interventions...
December 14, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/29237621/patient-characteristics-influence-the-choice-of-biological-drug-in-ra-and-will-make-non-tnfi-biologics-appear-more-harmful-than-tnfi-biologics
#8
Thomas Frisell, Eva Baecklund, Karin Bengtsson, Daniela Di Giuseppe, Helena Forsblad-d'Elia, Johan Askling
OBJECTIVES: With the wide range of biological disease-modifying anti-rheumatic drugs (bDMARDs) available for treating rheumatoid arthritis (RA), and limited evidence to guide the choice for individual patients, we wished to evaluate whether patient characteristics influence the choice of bDMARD in clinical practice, and to quantify the extent to which this would bias direct comparisons of treatment outcome. METHODS: Register-based study of all Swedish patients with RA initiating necrosis factor inhibitor (TNFi), rituximab, abatacept or tocilizumab in 2011-2015 as their first bDMARD (n=6481), or after switch from TNFi as first bDMARD (n=2829)...
December 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29237422/mdrd-vs-ckd-epi-in-comparison-to-51chromium-edta-a-cross-sectional-study-of-malaysian-ckd-cohort
#9
Maisarah Jalalonmuhali, Soo Kun Lim, Mohammad Nazri Md Shah, Kok Peng Ng
BACKGROUND: Accurate measurement of renal function is important: however, radiolabelled gold standard measurement of GFR is highly expensive and can only be used on a very limited scale. We aim to compare the performance of Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations in the multi-ethnic population attending University Malaya Medical Centre (UMMC). METHODS: This is a cross-sectional study recruiting patients, who attend UMMC Nephrology clinics on voluntary basis...
December 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29236562/from-narcotic-to-normalizer-the-misperception-of-methadone-treatment-and-the-persistence-of-prejudice-and-bias
#10
Joycelyn Sue Woods, Herman Joseph
This article concentrates on methadone maintenance as a normalizer for the impairments of opioid addiction, and the misunderstandings of it as a substitute for heroin that continues an opiate addiction. Methadone treatment was developed by Drs. Dole, Nyswander, and Kreek. Their cutting-edge theory transformed the way that opioid addiction is perceived and their work changed methadone from a narcotic to withdraw addicts to a medication that is a maintenance normalizer for a chronic condition. Their extensive research involved the physiological and sociological normalizing effects of methadone and medical safety of the medication (Dole & Nyswander, 1967)...
December 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29235174/big-data-and-medicine-a-big-deal
#11
Viktor Mayer-Schönberger, Erik Ingelsson
Big Data promises huge benefits for medical research. Looking beyond superficial increases in the amount of data collected, we identify three key areas where Big Data differs from conventional analyses of data samples: (1) data is captured more comprehensively relative to the phenomenon under study; this reduces some bias but surfaces important tradeoffs, such as between data quantity and data quality; (2) data is often analyzed using machine learning tools, such as neural networks rather than conventional statistical methods resulting in systems that over time capture insights implicit in data, but remain black boxes, rarely revealing causal connections; and (3) the purpose of the analyses of data is no longer simply answering existing questions, but hinting at novel ones and generating promising new hypotheses...
December 13, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29233094/short-and-long-term-outcomes-in-infective-endocarditis-patients-a-systematic-review-and-meta-analysis
#12
Tadesse Melaku Abegaz, Akshaya Srikanth Bahagavathula, Eyob Alemayehu Gebreyohannes, Alemayehu B Mekonnen, Tamrat Befekadu Abebe
BACKGROUND: Despite advances in medical knowledge, technology and antimicrobial therapy, infective endocarditis (IE) is still associated with devastating outcomes. No reviews have yet assessed the outcomes of IE patients undergoing short- and long-term outcome evaluation, such as all-cause mortality and IE-related complications. We conducted a systematic review and meta-analysis to examine the short- and long-term mortality, as well as IE-related complications in patients with definite IE...
December 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29231356/-acupuncture-for-diarrhea-predominant-irritable-bowel-syndrome-a-meta-analysis
#13
REVIEW
Duoxi Deng, Kuikui Guo, Jie Tan, Guilan Huang, Shuai Li, Quanrui Jiang, Jiao Xie, Hui Xie, Zhiqi Zhang, Ying Chen, Liang Peng
OBJECTIVE: To systematically evaluate the efficacy and safety of acupuncture on diarrhea-predominant irritable bowel syndrome (IBS) in the past five years. METHODS: Online databases, including CNKI, VIP, WANFANG, PubMed, CBM, ScienceDirect OnSite, Cochrane Library, etc. were searched for randomized controlled trials (RCTs) of acupuncture for diarrhea-predominant IBS. Retrieval time was from January of 2011 to January of 2016. According to modified Jadad standard, the bias risk and quality assessment of each RCT included were evaluated by two researchers...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231150/quality-of-reporting-and-risk-of-bias-in-therapeutic-otolaryngology-publications
#14
N M Kaper, K M A Swart, W Grolman, G J M G Van Der Heijden
BACKGROUND: High-quality trials have the potential to influence clinical practice. METHODS: Ten otolaryngology journals with the highest 2011 impact factors were selected and publications from 2010 were extracted. From all medical journals, the 20 highest impact factor journals were selected, and publications related to otolaryngology for 2010 and 2011 were extracted. For all publications, the reporting quality and risk of bias were assessed. RESULTS: The impact factor was 1...
December 12, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29230890/effects-of-analgesics-on-bone-mineral-density-a-longitudinal-analysis-of-the-prospective-swan-cohort-with-three-group-matching-weights
#15
Kazuki Yoshida, Zhi Yu, Gail A Greendale, Kristine Ruppert, Yinjuan Lian, Sara K Tedeschi, Tzu-Chieh Lin, Sebastien Haneuse, Robert J Glynn, Sonia Hernández-Díaz, Daniel H Solomon
PURPOSE: To examine the effects of analgesics on bone mineral density (BMD), which have not been examined in a longitudinal study with multiple measurements. METHODS: We investigated changes in BMD associated with new use of analgesics in a prospective longitudinal cohort of mid-life women. BMD and medication use were measured annually. We compared BMD among new users of acetaminophen, NSAIDs, and opioids. Adjustment for baseline covariates was conducted through propensity score matching weights...
December 12, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29230023/pharmacogenetics-predictors-of-methylphenidate-efficacy-in-childhood-adhd
#16
N M Myer, J R Boland, S V Faraone
Stimulant medication has long been effective in treating attention-deficit/hyperactivity disorder (ADHD) and is currently the first-line pharmacological treatment for children. Both methylphenidate and amphetamine modulate extracellular catecholamine levels through interaction with dopaminergic, adrenergic and serotonergic system components; it is therefore likely that catecholaminergic molecular components influence the effects of ADHD treatment. Using meta-analysis, we sought to identify predictors of pharmacotherapy to further the clinical implementation of personalized medicine...
December 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29229223/genders-and-individual-treatment-progress-in-non-binary-trans-individuals
#17
Andreas Koehler, Jana Eyssel, Timo O Nieder
BACKGROUND: Health care for transgender and transsexual (ie, trans) individuals has long been based on a binary understanding of gender (ie, feminine vs masculine). However, the existence of non-binary or genderqueer (NBGQ) genders is increasingly recognized by academic and/or health care professionals. AIM: To gain insight into the individual health care experiences and needs of binary and NBGQ individuals to improve their health care outcomes and experience. METHODS: Data were collected using an online survey study on experiences with trans health care...
December 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29228914/methods-to-perform-systematic-reviews-of-patient-preferences-a-literature-survey
#18
Tsung Yu, Nomin Enkh-Amgalan, Ganchimeg Zorigt
BACKGROUND: Systematic reviews are a commonly used research design in the medical field to synthesize study findings. At present-although several systematic reviews of patient preference studies are published-there is no clear guidance available for researchers to conduct this type of systematic review. The aim of our study was to learn the most current practice of conducting these systematic reviews by conducting a survey of the literature regarding reviews of quantitative patient preference studies...
December 11, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29228373/medical-treatment-or-surgery-for-colorectal-endometriosis-results-of-a-shared-decision-making-approach
#19
Paolo Vercellini, Maria Pina Frattaruolo, Riccardo Rosati, Dhouha Dridi, Anna Roberto, Paola Mosconi, Olga De Giorgi, Fulvia Milena Cribiù, Edgardo Somigliana
STUDY QUESTION: What is the degree of patient satisfaction in women with symptomatic colorectal endometriosis who choose medical or surgical treatment after a shared decision-making (SDM) process? SUMMARY ANSWER: The degree of satisfaction with treatment was high both in women who chose medical treatment with a low-dose oral contraceptive (OCP) or a progestin, and in those who chose to undergo surgical resection of bowel endometriosis. WHAT IS KNOWN ALREADY: Hormonal therapies and surgery for colorectal endometriosis have been investigated in non-comparative studies with inconsistent results...
December 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29226949/thrombolysis-for-acute-upper-extremity-deep-vein-thrombosis
#20
REVIEW
Joshua Feinberg, Emil Eik Nielsen, Janus C Jakobsen
BACKGROUND: About 5% to 10% of all deep vein thromboses occur in the upper extremities. Serious complications of upper extremity deep vein thrombosis, such as post-thrombotic syndrome and pulmonary embolism, may in theory be avoided using thrombolysis. No systematic review has assessed the effects of thrombolysis for the treatment of individuals with acute upper extremity deep vein thrombosis. OBJECTIVES: To assess the beneficial and harmful effects of thrombolysis for the treatment of individuals with acute upper extremity deep vein thrombosis...
December 11, 2017: Cochrane Database of Systematic Reviews
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