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https://www.readbyqxmd.com/read/29064711/schizophrenic-diblock-copolymer-functionalized-nanoparticles-as-temperature-responsive-pickering-emulsifiers
#1
Mikhil Ranka, Hari Katepalli, Daniel Blankschtein, T Alan Hatton
Stimuli-responsive pickering emulsions have received considerable attention in recent years, and the utilization of temperature as a stimulus has been of particular interest. Previous efforts have led to responsive systems that enable the formation of stable emulsions at room temperature, which can subsequently be triggered to destabilize with an increase in temperature. The development of a thermoresponsive system that exhibits the opposite response, however, i.e., one that can be triggered to form stable emulsions at elevated temperatures and subsequently be induced to phase separate at lower temperatures, has so far been lacking...
November 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29061353/intraradicular-appearances-affect-radiographic-interpretation-of-the-periapical-area
#2
Ana C Biscontine, Adam J Diliberto, John F Hatton, Karl F Woodmansey
INTRODUCTION: No research exists evaluating the influences of specific variables such as obturation length, radiodensity, or the presence of voids on interpretation of periradicular area. The purpose of this study was to evaluate the effects of obturation length, radiodensity, and the presence of voids on the radiographic interpretations of periapical areas. METHODS: In a Web-based survey, 3 test image groups of variable obturation lengths, radiodensities, and numbers of voids were presented to observers for evaluation of the periapical areas...
October 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29038599/widespread-white-matter-microstructural-differences-in-schizophrenia-across-4322-individuals-results-from-the-enigma-schizophrenia-dti-working-group
#3
S Kelly, N Jahanshad, A Zalesky, P Kochunov, I Agartz, C Alloza, O A Andreassen, C Arango, N Banaj, S Bouix, C A Bousman, R M Brouwer, J Bruggemann, J Bustillo, W Cahn, V Calhoun, D Cannon, V Carr, S Catts, J Chen, J-X Chen, X Chen, C Chiapponi, Kl K Cho, V Ciullo, A S Corvin, B Crespo-Facorro, V Cropley, P De Rossi, C M Diaz-Caneja, E W Dickie, S Ehrlich, F-M Fan, J Faskowitz, H Fatouros-Bergman, L Flyckt, J M Ford, J-P Fouche, M Fukunaga, M Gill, D C Glahn, R Gollub, E D Goudzwaard, H Guo, R E Gur, R C Gur, T P Gurholt, R Hashimoto, S N Hatton, F A Henskens, D P Hibar, I B Hickie, L E Hong, J Horacek, F M Howells, H E Hulshoff Pol, C L Hyde, D Isaev, A Jablensky, P R Jansen, J Janssen, E G Jönsson, L A Jung, R S Kahn, Z Kikinis, K Liu, P Klauser, C Knöchel, M Kubicki, J Lagopoulos, C Langen, S Lawrie, R K Lenroot, K O Lim, C Lopez-Jaramillo, A Lyall, V Magnotta, R C W Mandl, D H Mathalon, R W McCarley, S McCarthy-Jones, C McDonald, S McEwen, A McIntosh, T Melicher, R I Mesholam-Gately, P T Michie, B Mowry, B A Mueller, D T Newell, P O'Donnell, V Oertel-Knöchel, L Oestreich, S A Paciga, C Pantelis, O Pasternak, G Pearlson, G R Pellicano, A Pereira, J Pineda Zapata, F Piras, S G Potkin, A Preda, P E Rasser, D R Roalf, R Roiz, A Roos, D Rotenberg, T D Satterthwaite, P Savadjiev, U Schall, R J Scott, M L Seal, L J Seidman, C Shannon Weickert, C D Whelan, M E Shenton, J S Kwon, G Spalletta, F Spaniel, E Sprooten, M Stäblein, D J Stein, S Sundram, Y Tan, S Tan, S Tang, H S Temmingh, L T Westlye, S Tønnesen, D Tordesillas-Gutierrez, N T Doan, J Vaidya, N E M van Haren, C D Vargas, D Vecchio, D Velakoulis, A Voineskos, J Q Voyvodic, Z Wang, P Wan, D Wei, T W Weickert, H Whalley, T White, T J Whitford, J D Wojcik, H Xiang, Z Xie, H Yamamori, F Yang, N Yao, G Zhang, J Zhao, T G M van Erp, J Turner, P M Thompson, G Donohoe
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies...
October 17, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29032461/the-effect-of-ribose-pre-treatment-of-cortical-bone-on-%C3%AE-irradiation-sterilization-effectiveness
#4
Tarik Attia, Jindra Tupy, Dalal Asker, Benjamin Hatton, Marc Grynpas, Thomas Willett
Reconstruction of large skeletal defects is a significant and challenging issue. Tissue banks often use γ-irradiation (15-35 kGy) to sterilize bone allografts, which, however, drastically impairs the post-yield mechanical properties. In previous studies, we reported the development of a method that protects human bone collagen connectivity through ribose crosslinking while still undergoing γ-irradiation. Given these promising results, the next step was to determine if the presence of ribose within the bone tissue would interfere with the effectiveness of the γ-irradiation sterilization against bacteria...
October 14, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28977454/in-silico-design-of-context-responsive-mammalian-promoters-with-user-defined-functionality
#5
Adam J Brown, Suzanne J Gibson, Diane Hatton, David C James
Comprehensive de novo-design of complex mammalian promoters is restricted by unpredictable combinatorial interactions between constituent transcription factor regulatory elements (TFREs). In this study, we show that modular binding sites that do not function cooperatively can be identified by analyzing host cell transcription factor expression profiles, and subsequently testing cognate TFRE activities in varying homotypic and heterotypic promoter architectures. TFREs that displayed position-insensitive, additive function within a specific expression context could be rationally combined together in silico to create promoters with highly predictable activities...
October 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28961377/droplet-templated-antisolvent-spherical-crystallization-of-hydrophilic-and-hydrophobic-drugs-with-an-in-situ-formed-binder
#6
Tonghan Gu, Eunice W Q Yeap, Zheng Cao, Denise Z L Ng, Yinying Ren, Ran Chen, Saif A Khan, T Alan Hatton
This study presents a novel droplet-templated antisolvent spherical crystallization method applicable to both hydrophilic and hydrophobic drugs. In both cases, an alginate hydrogel binder forms in situ, concurrently with the crystallization process, effectively binding the drug crystals into monodisperse spheres. This study presents a detailed process description with mass transfer modeling, and with characterization of the obtained alginate/drug spheres in terms of morphology, composition, and drug loading...
September 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28940024/predictors-of-health-related-quality-of-life-in-patients-treated-with-neck-dissection-for-head-and-neck-cancer
#7
Elise M Gane, Steven M McPhail, Anna L Hatton, Benedict J Panizza, Shaun P O'Leary
Patients with head and neck cancer can report reduced health-related quality of life several years after treatment. The aim of this study was to identify risk factors for reduced quality of life in patients up to 5 years following neck dissection. This cross-sectional study was conducted at two hospitals in Brisbane, Australia. Patients completed two measures of quality of life: the Neck Dissection Impairment Index (NDII), a region- and disease-specific tool, and the Assessment of Quality of Life-4 Domains, a general tool...
December 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28937598/the-effect-of-rankl-opg-balance-on-reducing-implant-complications
#8
REVIEW
Elizabeth R Kapasa, Peter V Giannoudis, Xiaodong Jia, Paul V Hatton, Xuebin B Yang
Despite the phenomenal success of implants particularly in the realms of dentistry and orthopaedics, there are still challenges to overcome. The failure of implants resulting from infection, prosthetic loosening, and non-union continue to be the most notorious examples. The cascade of fracture healing and bone repair, especially with the presence of an implant, is complex because it involves a multifaceted immune response alongside the intricate process of bone formation and remodelling. Bone loss is a serious clinical problem that is frequently accompanied by chronic inflammation, illustrating that there is a convoluted relationship between inflammation and bone erosion...
September 22, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28844584/consistency-of-psychotropic-drug-drug-interactions-listed-in-drug-monographs
#9
REVIEW
Xinyue Liu, Randy C Hatton, Yanmin Zhu, Juan M Hincapie-Castillo, Regina Bussing, Marie Barnicoat, Almut G Winterstein
BACKGROUND: With an increasing prevalence of psychotropic polypharmacy, clinicians depend on drug-drug interaction (DDI) references to ensure safe regimens, but the consistency of such information is frequently questioned. OBJECTIVES: To evaluate the consistency of psychotropic DDIs documented in Clinical Pharmacology (CP), Micromedex (MM), and Lexicomp (LC) and summarize consistent psychotropic DDIs. METHODS: In May 2016, we extracted severe or major psychotropic DDIs for 102 psychotropic drugs, including central nervous system (CNS) stimulants, antidepressants, an antimanic agent (lithium), antipsychotics, anticonvulsants, and anxiolytics-sedatives-hypnotics from CP, MM, and LC...
August 22, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28836795/correction-to-co2-reactive-ionic-liquid-surfactants-for-the-control-of-colloidal-morphology
#10
Paul Brown, Vishnu Sresht, Burak H Eral, Andrew Fiore, César de la Fuente-Núñez, Marcus O'Mahony, Gabriel P Mendes, William T Heller, Patrick S Doyle, Daniel Blankschtein, T Alan Hatton
No abstract text is available yet for this article.
August 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28822258/photochemical-oxidation-of-dimethylsulphide-to-dimethylsulphoxide-in-estuarine-and-coastal-waters
#11
Günther Uher, J Julian Pillans, Angela D Hatton, Robert C Upstill-Goddard
Dimethylsulphide (DMS) photo-oxidation and dimethylsulphoxide (DMSO) photoproduction were estimated in 26 laboratory irradiations of coastal samples from NE England (Tyne estuary) and W Scotland (Loch Linnhe and River Nant at Taynuilt). Pseudo-first order rate constants of DMS photo-oxidation (0.038 h(-1) to 0.345 h(-1)) and DMSO photo-production (0.017 h(-1) to 0.283 h(-1)) varied by one order of magnitude and were lowest in the coastal North Sea. Estuarine samples (salinity S < 30) had a mean DMSO yield of 96 ± 16% (n = 14), consistent with 1:1 M conversion via photosensitised oxidation by singlet oxygen...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28821007/measurement-tools-for-mental-health-problems-and-mental-well-being-in-people-with-severe-or-profound-intellectual-disabilities-a-systematic-review
#12
REVIEW
Samantha Flynn, Leen Vereenooghe, Richard P Hastings, Dawn Adams, Sally-Ann Cooper, Nick Gore, Chris Hatton, Kerry Hood, Andrew Jahoda, Peter E Langdon, Rachel McNamara, Chris Oliver, Ashok Roy, Vasiliki Totsika, Jane Waite
Mental health problems affect people with intellectual disabilities (ID) at rates similar to or in excess of the non-ID population. People with severe ID are likely to have persistent mental health problems. In this systematic review (PROSPERO 2015:CRD42015024469), we identify and evaluate the methodological quality of available measures of mental health problems or well-being in individuals with severe or profound ID. Electronic searches of ten databases identified relevant publications. Two reviewers independently reviewed titles and abstracts of retrieved records (n=41,232) and full-text articles (n=573)...
November 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28815152/populating-physician-biographical-pages-based-on-emr-data
#13
Feichen Shen, Sunghwan Sohn, Majid Rastegar-Mojarad, Sijia Liu, Joshua J Pankratz, Michael A Hatton, Nancy Sowada, Om K Shrestha, Shawna L Shurson, Hongfang Liu
The physicians' biographical pages are essential in providing information about physicians' specialties. However, physicians may not have biographical pages or the current pages are not comprehensive. We hypothesize that physicians' specialty information can be mined from Electronic Medical Records (EMRs) of their patients. We proposed an automated physician specialty populating (PSP) system that analyzes physician-ascertained diagnoses in EMRs, aggregates them to an appropriate granularity based on the current biographical pages, and populates the biographical pages accordingly...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28800298/impact-of-field-number-and-beam-angle-on-functional-image-guided-lung-cancer-radiotherapy-planning
#14
Bilal A Tahir, Chris M Bragg, Jim M Wild, James A Swinscoe, Sarah E Lawless, Kerry A Hart, Matthew Q Hatton, Rob H Ireland
To investigate the effect of beam angles and field number on functionally-guided intensity modulated radiotherapy (IMRT) normal lung avoidance treatment plans that incorporate hyperpolarised helium-3 magnetic resonance imaging ((3)He MRI) ventilation data. Eight non-small cell lung cancer patients had pre-treatment (3)He MRI that was registered to inspiration breath-hold radiotherapy planning computed tomography. IMRT plans that minimised the volume of total lung receiving  ⩾20 Gy (V20) were compared with plans that minimised (3)He MRI defined functional lung receiving  ⩾20 Gy (fV20)...
August 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28790180/pseudomonas-aeruginosa-lasb-protease-impairs-innate-immunity-in-mice-and-humans-by-targeting-a-lung-epithelial-cystic-fibrosis-transmembrane-regulator-il-6-antimicrobial-repair-pathway
#15
Vinciane Saint-Criq, Bérengère Villeret, Fabien Bastaert, Saadé Kheir, Aurélie Hatton, Aurélie Cazes, Zhou Xing, Isabelle Sermet-Gaudelus, Ignacio Garcia-Verdugo, Aleksander Edelman, Jean-Michel Sallenave
BACKGROUND: Pseudomonas aeruginosa lung infections are a huge problem in ventilator-associated pneumonia, cystic fibrosis (CF) and in chronic obstructive pulmonary disease (COPD) exacerbations. This bacterium secretes virulence factors that may subvert host innate immunity. OBJECTIVE: We evaluated the effect of P. aeruginosa elastase LasB, an important virulence factor secreted by the type II secretion system, on ion transport, innate immune responses and epithelial repair, both in vitro and in vivo...
August 8, 2017: Thorax
https://www.readbyqxmd.com/read/28765402/monitoring-risk-factors-of-cardiovascular-disease-in-cancer-survivors
#16
Ambika Kapoor, Vineet Prakash, Mallika Sekhar, Diana M Greenfield, Matthew Hatton, Michael Ej Lean, Pankaj Sharma, Thang S Han
There exist published literature for cardiovascular disease (CVD) risk monitoring in cancer survivors but the extent of monitoring in clinical oncology practice is unknown. We performed an interactive survey at a Royal College of Physicians conference (11 November 2016) attended by practitioners with an interest in late effects of cancer treatment and supplemented the survey with an audit among 32 lung cancer survivors treated at St Peter's NHS Hospital in 2012-2016. Among the practitioners, 40% reported CVD risk monitoring performed at least annually, which is compatible with European Group for Blood and Marrow Transplantation Guidelines, but 31% indicated that monitoring was never performed...
July 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28764901/providers-perspectives-on-self-regulation-impact-their-use-of-responsive-feeding-practices-in-child-care
#17
Dipti A Dev, Katherine E Speirs, Natalie A Williams, Samantha Ramsay, Brent A McBride, Holly Hatton-Bowers
Supporting children's self-regulation in eating through caregivers' practice of responsive feeding is paramount to obesity prevention, and while much attention has been given to supporting children's self-regulation in eating through parents' responsive feeding practices in the home setting, little attention has been given to this issue in childcare settings. This qualitative study examines childcare providers' perspectives on using responsive feeding practices with young children (2-5years). Individual semi-structured interviews were conducted with providers until saturation was reached...
July 29, 2017: Appetite
https://www.readbyqxmd.com/read/28752866/alginate-based-hydrogels-functionalised-at-the-nanoscale-using-layer-by-layer-assembly-for-potential-cartilage-repair
#18
P Gentile, C Ghione, A M Ferreira, A Crawford, P V Hatton
Injuries to articular cartilage are frequently difficult to repair, in part because of the poor regenerative capacity of this tissue. To date, no successful system for complete regeneration of the most challenging cartilage defects has been demonstrated. The aim of this work was to develop functionalised hydrogels at the nanoscale by Layer-by-Layer (LbL) assembly to promote cartilage healing. Hydrogels, based on sodium alginate (NaAlg) and gelatin (G), were prepared by an external gelation method consisting of CaCl2 diffusion and genipin addition for G crosslinking...
August 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28742428/neck-and-upper-limb-dysfunction-in-patients-following-neck-dissection-looking-beyond-the-shoulder
#19
MULTICENTER STUDY
Elise M Gane, Shaun P O'Leary, Anna L Hatton, Benedict J Panizza, Steven M McPhail
Objective To measure patient-perceived upper limb and neck function following neck dissection and to investigate potential associations between clinical factors, symptoms, and function. Study Design Cross-sectional. Setting Two tertiary hospitals in Brisbane, Australia. Subjects and Methods Inclusion criteria: patients treated with neck dissection (2009-2014). EXCLUSION CRITERIA: aged <18 years, accessory nerve or sternocleidomastoid sacrifice, previous neck dissection, preexisting shoulder/neck injury, and inability to provide informed consent (cognition, insufficient English)...
October 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28731643/transcriptome-based-identification-of-the-optimal-reference-cho-genes-for-normalisation-of-qpcr-data
#20
Adam J Brown, Suzanne Gibson, Diane Hatton, David C James
Real-time quantitative PCR (qPCR) is the standard method for determination of relative changes in mRNA transcript abundance. Analytical accuracy, precision and reliability are critically dependent on the selection of internal control reference genes. In this study, the authors have identified optimal reference genes that can be utilised universally for qPCR analysis of CHO cell mRNAs. Initially, transcriptomic datasets were analysed to identify eight endogenous genes that exhibited high expression stability across four distinct CHO cell lines sampled in different culture phases...
July 21, 2017: Biotechnology Journal
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