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JOURNAL ARTICLE
Mathew Stewart, Eric Andrieux, James Blinkhorn, Maria Guagnin, Ricardo Fernandes, Nils Vanwezer, Amy Hatton, Mesfer Alqahtani, Iyad Zalmout, Richard Clark-Wilson, Yahya S A Al-Mufarreh, Mahmoud Al-Shanti, Badr Zahrani, Abdulaziz Al Omari, Faisal Al-Jibreen, Abdullah M Alsharekh, Eleanor M L Scerri, Nicole Boivin, Michael D Petraglia, Huw S Groucutt
Recent advances in interdisciplinary archaeological research in Arabia have focused on the evolution and historical development of regional human populations as well as the diverse patterns of cultural change, migration, and adaptations to environmental fluctuations. Obtaining a comprehensive understanding of cultural developments such as the emergence and lifeways of Neolithic groups has been hindered by the limited preservation of stratified archaeological assemblages and organic remains, a common challenge in arid environments...
2024: PloS One
#2
JOURNAL ARTICLE
Abby Dunn, Patrick Fenton, Sam Cartwright-Hatton
INTRODUCTION: When parents of dependent children are treated in psychiatric inpatient hospital, it typically involves separation of parent and child for the duration of treatment, which can be highly distressing to the dyad and can result in disruption to the parent-child relationship. Parents who have experienced hospitalisation have expressed a desire for their parenting identity to be recognized and appropriately engaged with during their treatment. This recognition includes provision of interventions which support them as parents to limit the impact of their mental health on their children...
2024: Frontiers in Psychiatry
#3
JOURNAL ARTICLE
Nonleaching Biocidal N-Halamine-Functionalized Polyamine-, Guanidine-, and Hydantoin-Based Coatings.
Lev Bromberg, Beatriz Magariños, Angel Concheiro, T Alan Hatton, Carmen Alvarez-Lorenzo
Fibrous materials with inherent antimicrobial properties can help in real-time deactivation of microorganisms, enabling multiple uses while reducing secondary infections. Coatings with antiviral polymers enhance the surface functionality for existing and potential future pandemics. Herein, we demonstrated a straightforward route toward biocidal surface creation using polymers with nucleophilic biguanide, guanidine, and hydantoin groups that are covalently attached onto a solid support. Biocidal poly( N -vinylguanidine) (PVG) and poly(allylamine- co -4-aminopyridine- co -5-(4-hydroxybenzylidene)hydantoin) (PAH) were introduced for coating applications along with commercially available polyvinylamine (PVAm) and poly(hexamethylene biguanide) (PHMB)...
April 10, 2024: Industrial & Engineering Chemistry Research
#4
JOURNAL ARTICLE
Leah Williams, Fiona L Hatton, Maria Cristina Righetti, Elisa Mele
Essential oils have been identified as effective natural compounds to prevent bacterial infections and thus are widely proposed as bioactive agents for biomedical applications. Across the literature, various essential oils have been incorporated into electrospun fibres to produce materials with, among others, antibacterial, anti-inflammatory and antioxidant activity. However, limited research has been conducted so far on the effect of these chemical products on the physical characteristics of the resulting composite fibres for extended periods of time...
April 7, 2024: Polymers
#5
JOURNAL ARTICLE
Anna L Hatton, Mark D Chatfield, Thomas Cattagni, Bill Vicenzino
BACKGROUND: Peripheral neuropathy is one of the most common complications of type 2 diabetes, which can lead to impaired balance and walking. Innovative footwear devices designed to stimulate foot sensory receptors, such as vibrating insoles, could offer a new route to improve motor impairments in people with diabetic peripheral neuropathy (DPN). RESEARCH QUESTION: Does wearing vibrating insoles for the first time alter measures of balance, walking, and ankle-foot muscle activity, in people with DPN? METHODS: A randomised cross-over study was conducted with 18 ambulant men and women with a diagnosis of DPN...
April 9, 2024: Gait & Posture
#6
JOURNAL ARTICLE
Carlene L Zindl, C Garrett Wilson, Awalpreet S Chadha, Lennard W Duck, Baiyi Cai, Stacey N Harbour, Yoshiko Nagaoka-Kamata, Robin D Hatton, Min Gao, David A Figge, Casey T Weaver
Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier1-3 . T cells, but not innate lymphoid cells, have an indispensable role in sustaining the IL-22 signalling that is required for the protection of colonic crypts against invasion during infection by the enteropathogen Citrobacter rodentium4 (Cr). However, the intestinal epithelial cell (IEC) subsets targeted by T cell-derived IL-22, and how T cell-derived IL-22 sustains activation in IECs, remain undefined. Here we identify a subset of absorptive IECs in the mid-distal colon that are specifically targeted by Cr and are differentially responsive to IL-22 signalling...
April 10, 2024: Nature
#7
JOURNAL ARTICLE
David T Lubkin, Krislynn M Mueck, Gabrielle E Hatton, Jason B Brill, Mariela Sandoval, Jessica C Cardenas, Charles E Wade, Bryan A Cotton
OBJECTIVES: Some centers have recommended including concentrated fibrinogen replacement in massive transfusion protocols (MTPs). Given our center's policy of aggressive early balanced resuscitation (1:1:1), beginning prehospital, we hypothesized that our rates of hypofibrinogenemia may be lower than those previously reported. METHODS: In this retrospective cohort study, patients presenting to our trauma center November 2017 to April 2021 were reviewed. Patients were defined as hypofibrinogenemic (HYPOFIB) if admission fibrinogen <150 or rapid thrombelastography angle <60...
2024: Trauma Surgery & Acute Care Open
#8
JOURNAL ARTICLE
Daniel Hatton, Jaehoon Cha, Stephen Riggs, Peter J Harrison, Jeyan Thiyagalingam, Daniel K Clare, Kyle L Morris
The widespread adoption of cryoEM technologies for structural biology has pushed the discipline to new frontiers. A significant worldwide effort has refined the single-particle analysis (SPA) workflow into a reasonably standardized procedure. Significant investments of development time have been made, particularly in sample preparation, microscope data-collection efficiency, pipeline analyses and data archiving. The widespread adoption of specific commercial microscopes, software for controlling them and best practices developed at facilities worldwide has also begun to establish a degree of standardization to data structures coming from the SPA workflow...
April 1, 2024: Acta Crystallographica. Section D, Structural Biology
#9
JOURNAL ARTICLE
Dimitar Karadzhov, Joanne Lee, George Hatton, Ross G White, Laura Sharp, Abdul Jalloh, Julie Langan Martin
Concerned with sustainably alleviating mental distress and promoting the right to health worldwide, global mental health (GMH) is practised across various contexts spanning the humanitarian-development-peace nexus. The inherently intersectoral and multidisciplinary nature of GMH calls for competency frameworks and training programmes that embody diversity, decolonisation and multiprofessionalism. Existing competency frameworks have failed to capture the multi-sectoral, inter-professional nature of contemporary GMH practice...
2024: Global Mental Health
#10
JOURNAL ARTICLE
Rubin M Tuder, Aneta Gandjeva, Sarah Williams, Sushil Kumar, Vitaly O Kheyfets, Kyle Matthew Hatton-Jones, Jacqueline R Starr, Jeong Yun, Jason Hong, Nicholas P West, Kurt R Stenmark
RATIONALE: Idiopathic Pulmonary Arterial Hypertension (IPAH) is characterized by extensive pulmonary vascular remodeling due to plexiform and obliterative lesions, media hypertrophy, inflammatory cell infiltration, and alterations of the adventitia. OBJECTIVE: Test the hypothesis that microscopic IPAH vascular lesions express unique molecular profiles, which collectively are different from control pulmonary arteries. METHODS: We used digital spatial transcriptomics to profile the genome-wide differential transcriptomic signature of key pathological lesions (plexiform, obliterative, intima+media hypertrophy, and adventitia) in IPAH lungs (n= 11) and compared these data to the intima+media and adventitia of control pulmonary artery (n=5)...
April 3, 2024: American Journal of Respiratory and Critical Care Medicine
#11
JOURNAL ARTICLE
Abigail L D Tadenev, Courtney L Hatton, Robert W Burgess
BACKGROUND: Inhibition of HDAC6 has been proposed as a broadly applicable therapeutic strategy for Charcot-Marie-Tooth disease (CMT). Inhibition of HDAC6 increases the acetylation of proteins important in axonal trafficking, such as α-tubulin and Miro, and has been shown to be efficacious in several preclinical studies using mouse models of CMT. AIMS: Here, we sought to expand on previous preclinical studies by testing the effect of genetic deletion of Hdac6 on mice carrying a humanized knockin allele of Gars1, a model of CMT-type 2D...
March 29, 2024: Journal of the Peripheral Nervous System: JPNS
#12
JOURNAL ARTICLE
Alesha A Hatton, Fei-Fei Cheng, Tian Lin, Ren-Juan Shen, Jie Chen, Zhili Zheng, Jia Qu, Fan Lyu, Sarah E Harris, Simon R Cox, Zi-Bing Jin, Nicholas G Martin, Dongsheng Fan, Grant W Montgomery, Jian Yang, Naomi R Wray, Riccardo E Marioni, Peter M Visscher, Allan F McRae
DNA methylation is an ideal trait to study the extent of the shared genetic control across ancestries, effectively providing hundreds of thousands of model molecular traits with large QTL effect sizes. We investigate cis DNAm QTLs in three European (n = 3701) and two East Asian (n = 2099) cohorts to quantify the similarities and differences in the genetic architecture across populations. We observe 80,394 associated mQTLs (62.2% of DNAm probes with significant mQTL) to be significant in both ancestries, while 28,925 mQTLs (22...
March 28, 2024: Nature Communications
#13
JOURNAL ARTICLE
Thomas L Williams, Irshad M Taily, Lewis Hatton, Andrey A Berezin, Yi-Lin Wu, Vicent Moliner, Katarzyna Świderek, Yu-Hsuan Tsai, Louis Y P Luk
Secondary amines, due to their reactivity, can transform protein templates into catalytically active entities, accelerating the development of artificial enzymes. However, existing methods, predominantly reliant on modified ligands or N-terminal prolines, impose significant limitations on template selection. Here, genetic code expansion was used to break this boundary, enabling secondary amines to be incorporated into alternative proteins and positions of choice. Pyrrolysine analogues carrying different secondary amines, namely unnatural amino acids 1-3, could be incorporated into superfolder green fluorescent protein (sfGFP), multidrug-binding LmrR and nucleotide-binding dihydrofolate reductase (DHFR)...
March 28, 2024: Angewandte Chemie
#14
JOURNAL ARTICLE
Caron A C Clark, Holly Hatton-Bowers, Kimia Akhavein, Sarah Rasby, Gilbert R Parra
INTRODUCTION: Early childhood educators (ECEs) play a critical role in supporting the development of young children's executive functions (EF). EF, in turn, underpins lifelong resilience and well-being. Unfortunately, many ECEs report adverse childhood experiences (ACEs) that may compound high stress levels associated with an emotionally and physically demanding profession. ACEs have well-established negative implications for adult well-being and may dampen ECEs' capacities to engage in emotionally responsive interactions with children...
2024: Frontiers in Psychology
#15
JOURNAL ARTICLE
Kelly E Sanders, Gabrielle E Hatton, Atharwa R Mankame, Addison C Allen, Sarah Cunningham, Jan Michael Van Gent, Erin E Fox, Xu Zhang, Charles E Wade, Bryan A Cotton, Jessica C Cardenas
INTRODUCTION: Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in trauma patients, despite chemoprophylaxis. Statins have been shown capable of acting upon the endothelium. We hypothesized that statin therapy in the pre- or in-hospital settings leads to a decreased incidence of VTE. METHODS: We conducted a retrospective cohort study of injured patients who received statin therapy pre- or in-hospital. Adult, highest-level trauma activation patients admitted January 2018 - June 2022 were included...
March 25, 2024: Journal of Trauma and Acute Care Surgery
#16
JOURNAL ARTICLE
Kyle M Hatton-Jones, Nicholas P West, Mike W C Thang, Pin-Yen Chen, Peter Davoren, Allan W Cripps, Amanda J Cox
BACKGROUND: The contributions of the gut microbiota to obesity and metabolic disease represent a potentially modifiable factor that may explain variation in risk between individuals. This study aimed to explore relationships among microbial composition and imputed functional attributes, a range of soluble metabolic and immune indices, and gene expression markers in males with or without evidence of metabolic dysregulation (MetDys). METHODS: This case-control study included healthy males (n=15; 41...
March 21, 2024: Journal of obesity & metabolic syndrome
#17
Judy Chen, Alexander Ngo, Raúl Rodríguez-Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S Keller, Fernando Cendes, Clarissa L Yasuda, Marina K M Alvim, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K Focke, Barbara Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J O'Brien, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia M Desmond, Elaine Lui, Gian Marco Duma, Paolo Bonanni, Alice Ballerini, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P Doherty, Gianpiero L Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Tobias Bauer, Bernd Weber, Benoit Caldairou, Chantal Depondt, Julie Absil, Sarah J A Carr, Eugenio Abela, Mark P Richardson, Orrin Devinsky, Heath Pardoe, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N Hatton, Donatello Arienzo, Sjoerd B Vos, Mina Ryten, Peter N Taylor, John S Duncan, Christopher D Whelan, Marian Galovic, Gavin P Winston, Sophia I Thomopoulos, Paul M Thompson, Sanjay M Sisodiya, Angelo Labate, Carrie R McDonald, Lorenzo Caciagli, Neda Bernasconi, Andrea Bernasconi, Sara Larivière, Dewi Schrader, Boris C Bernhardt
OBJECTIVES: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey and white matter structures. Evidence supports a progressive condition although the temporal evolution of TLE is poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural alterations in TLE patients across the adult lifespan. We charted both grey and white matter changes and explored the covariance of age-related alterations in both compartments...
March 6, 2024: bioRxiv
#18
JOURNAL ARTICLE
Ian A Hatton, Onofrio Mazzarisi, Ada Altieri, Matteo Smerlak
The worldwide loss of species diversity brings urgency to understanding how diverse ecosystems maintain stability. Whereas early ecological ideas and classic observations suggested that stability increases with diversity, ecological theory makes the opposite prediction, leading to the long-standing "diversity-stability debate." Here, we show that this puzzle can be resolved if growth scales as a sublinear power law with biomass (exponent <1), exhibiting a form of population self-regulation analogous to models of individual ontogeny...
March 15, 2024: Science
#19
JOURNAL ARTICLE
Amanda A Herrmann, Bo B Podgorski, Sarah J Hatton, Ella A Chrenka, Leah R Hanson, Steven D Jackson
OBJECTIVE: To investigate whether racial, ethnic, and linguistic disparities exist upon discharge from an acute inpatient rehabilitation facility (IRF) by examining change in FIM score and discharge destination. DESIGN: This is a retrospective study using our IRF's data from the Uniform Data System of Medical Rehabilitation (UDSMR) from 2013 to 2019. Functional independence measure (FIM) and discharge destination were compared between race, language, and ethnic groups with adjustment for patient characteristics...
March 2, 2024: Archives of Physical Medicine and Rehabilitation
#20
JOURNAL ARTICLE
Jake G Edmans, Craig Murdoch, Paul V Hatton, Lars Siim Madsen, Martin E Santocildes-Romero, Sebastian G Spain, Helen E Colley
Protein-based biologics constitute a rapidly expanding category of therapeutic agents with high target specificity. Their clinical use has dramatically increased in recent years, but administration is largely via injection. Drug delivery across the oral mucosa is a promising alternative to injections, in order to avoid the gastrointestinal tract and first-pass metabolism. Current drug delivery formulations include liquid sprays, mucoadhesive tablets and films, which lack dose control in the presence of salivary flow...
2024: Biomed Mater Devices
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