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Katie Bardsley, Agnieska Kwarciak, Christine Freeman, Ian Brook, Paul Hatton, Aileen Crawford
The regeneration of large bone defects remains clinically challenging. The aim of our study was to use a rat model to use nasal chondrocytes to engineer a hypertrophic cartilage tissue which could be remodelled into bone in vivo by endochondral ossification. Primary adult rat nasal chondrocytes were isolated from the nasal septum, the cell numbers expanded in monolayer culture and the cells cultured in vitro on polyglycolic acid scaffolds in chondrogenic medium for culture periods of 5-10 weeks. Hypertrophic differentiation was assessed by determining the temporal expression of key marker genes and proteins involved in hypertrophic cartilage formation...
October 11, 2016: Biomaterials
Tracy Hatton, Eleanor Grimshaw, John Vargo, Erica Seville
Business Continuity Planning (BCP) is well established as a key plank in an organisation's risk management process. But how effective is BCP when disaster strikes? This paper examines the experiences of organisations following the 2010-11 Canterbury, New Zealand earthquakes. The study finds that BCP was helpful for all organisations interviewed but more attention is needed on the management of societal and personal impacts; development of employee resilience, identification of effective crisis leaders; right-sizing plans and planning to seize opportunities post-disaster...
2016: Journal of Business Continuity & Emergency Planning
Ankur Gupta, Vivek Narsimhan, T Alan Hatton, Patrick S Doyle
The evolution of droplet size during nanoemulsion formation is critical for the ra- tional design of nanoemulsions in areas such as drug delivery and materials synthesis. In this article, we discuss the relative importance of various time scales involved in nanoemulsion formation and propose a population balance model for droplet breakup that takes into account the droplet's internal viscosity. The proposed model gives a qualitative agreement with average droplet size and polydispersity data for nanoemul- sions prepared by high pressure homogenization and ultrasonication...
October 11, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Mélanie Faria da Cunha, Juliette Simonin, Ali Sassi, Romain Freund, Aurélie Hatton, Charles-Henry Cottart, Nadia Elganfoud, Rachid Zoubairi, Corina Dragu, Jean Philippe Jais, Alexandre Hinzpeter, Aleksander Edelman, Isabelle Sermet-Gaudelus
The nasal epithelium of the mouse closely mimics the bioelectrical phenotype of the human airways. Ion transport across the nasal epithelium induces a nasal transepithelial potential difference. Its measurement by a relatively non-invasive method adapted from humans allows in vivo longitudinal measurements of CFTR-dependent ionic transport in the murine nasal mucosa. This test offers a useful tool to assess CFTR function in preclinical studies for novel therapeutics modulating CFTR activity. Here we extensively review work done to assess transepithelial transport in the murine respiratory epithelium in the basal state and after administration of CFTR modulators...
October 4, 2016: International Journal of Biochemistry & Cell Biology
Xiao Su, T Alan Hatton
Redox-active materials hold great promise as platforms for selective liquid-phase separations. In contrast to capacitive electrodes that rely purely on double-layer charge for deionization, redox-modified electrodes can be used to control Faradaic reactions at the interface to selectively bind various charged and uncharged molecules, thus modulating surface interactions through electrochemical potential solely. These electrodes can be composed of a range of functional materials, from organic and organometallic polymers to inorganic crystalline compounds, each relying on its own distinct ion-exchange process...
September 9, 2016: Advances in Colloid and Interface Science
Demetra S Achilleos, T Alan Hatton
We report the development of a dual-electrode Pseudocapacitive Separation Technology (PSST) to capture quantitatively, remotely, and in a reversible manner, value-added carboxylate salts of environmental and industrial significance. The nanostructured pseudocapacitive cell exhibits elegant molecular selectivity towards ionic species: upon electrochemical oxidation, a poly(vinyl ferrocene) (PVF)-based anodic electrode shows high selectivity towards carboxylates based on their basicity and hydrophobicity. Simultaneously, on the other side of the electrochemical cell, a poly(anthraquinone) (PAQ)-based cathodic electrode undergoes electrochemical reduction and captures the counterions of these carboxylates...
October 4, 2016: ACS Applied Materials & Interfaces
B J Slotman, C Faivre-Finn, H van Tinteren, A Keijser, J O Praag, J Knegjens, M Hatton, I van Dam, A van der Leest, B Reymen, J Stigt, K Haslett, D Tripathi, E Smit, S Senan
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Myriam Mesbahi, Michal Shteinberg, Michael Wilschanski, Aurelie Hatton, Thao Nguyen-Khoa, Hannah Friedman, Michael Cohen, Virginie Escabasse, Muriel Le Bourgeois, Vicenzina Lucidi, Isabelle Sermet-Gaudelus, Laurence Bassinet, Galit Livnat
Ivacaftor, a CFTR potentiator, has been found to improve CFTR function and clinical outcomes in patients with cystic fibrosis (CF) gating mutations. We investigated the effects of ivacaftor on CFTR functional measurement in CF patients carrying gating mutations other than p.Gly551Asp. Two siblings aged 13 and 12 carrying the p.Ser549Asn mutation, two sisters (45 and 43years old) compound heterozygotes for p.Asp1152His and p.Gly1244Glu, a 37year old man homozygous for the p.Gly1244Glu mutation, and a 7year old girl with p...
September 19, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Anna L Hatton, François Hug, Sarah H Chen, Christine Reid, Nicole A Sorensen, Kylie Tucker
Middle-aged adults with painful hip conditions show balance impairments that are consistent with an increased risk of falls. Pathological changes at the hip, accompanied by pain, may accelerate pre-existing age-related balance deficits present in midlife. To consider the influence of pain alone, we investigated the effects of acute experimental hip muscle pain on dynamic single-limb balance in middle-aged adults. Thirty-four healthy adults aged 40-60 years formed two groups (Group-1: n=16; Group-2: n=18). Participants performed four tasks: Reactive Sideways Stepping (ReactSide); Star Excursion Balance Test (SEBT); Step Test; Single-Limb Squat; before and after an injection of hypertonic saline into the right gluteus medius muscle (Group-1) or ∼5min rest (Group-2)...
September 13, 2016: Gait & Posture
Barbara C Cahill, Nathan D Hatton, John J Ryan
No abstract text is available yet for this article.
August 17, 2016: Journal of Heart and Lung Transplantation
R H Ireland, B A Tahir, J M Wild, C E Lee, M Q Hatton
For patients with lung cancer undergoing curative intent radiotherapy, functional lung imaging can be incorporated into treatment planning to modify the dose distribution within non-target volume lung by differentiation of lung regions that are functionally defective or viable. This concept of functional image-guided lung avoidance treatment planning has been investigated with several imaging modalities, primarily single photon emission computed tomography (SPECT), but also hyperpolarised gas magnetic resonance (MR) imaging, positron emission tomography (PET) and computed tomography (CT)-based measures of lung biomechanics...
November 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
Hari Katepalli, Arijit Bose, T Alan Hatton, Daniel Blankschtein
We investigate the use of particle hydrophilicity as a tool for emulsion destabilization in Triton-X-100-stabilized hexadecane-in-water emulsions. The hydrophilicity of the particles added to the aqueous phase was found to have a pronounced effect on the stability of the emulsion. Specifically, the addition of hydrophilic fumed silica particles to the aqueous phase resulted in coarsening of the emulsion droplets, with droplet flocculation observed at higher particle concentrations. On the other hand, when partially hydrophobic fumed silica particles were added to the aqueous phase, coarsening of the emulsion droplets was observed at low particle concentrations and phase separation of oil and water was observed at higher particle concentrations...
October 5, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
E Emerson, J Robertson, S Baines, C Hatton
BACKGROUND: Reducing harmful levels of alcohol consumption among children is an important public health concern internationally and in many high income countries. Little is known about levels and predictors of alcohol use among children with intellectual disability (ID). METHOD: Secondary analysis of child self-report data at age 11 years collected in the UK's Millennium Cohort Study. RESULTS: Children with ID were significantly more likely to: have used alcohol in the last 4 weeks; to have had five or more alcoholic drinks on one occasion; to have had five or more alcoholic drinks or been intoxicated on one occasion; to have more positive attitudes about the psychological and social benefits of drinking; and to have less negative attitudes about the social and physical costs of drinking...
September 1, 2016: Journal of Intellectual Disability Research: JIDR
Heng-Jui Liu, Jheng-Cyuan Lin, Yue-Wen Fang, Jing-Ching Wang, Bo-Chao Huang, Xiang Gao, Rong Huang, Philip R Dean, Peter D Hatton, Yi-Ying Chin, Hong-Ji Lin, Chien-Te Chen, Yuichi Ikuhara, Ya-Ping Chiu, Chia-Seng Chang, Chun-Gang Duan, Qing He, Ying-Hao Chu
A novel artificially created MnO2 monolayer system has been demonstrated in atomically controlled epitaxial perovskite heterostructures. With careful design of different electrostatic boundary conditions, a magnetic transition as well as a metal-insulator transition of the MnO2 monolayer has been unveiled, providing a fundamental understanding of the dimensionality-confined strongly correlated electron systems and a direction to design new electronic devices.
August 29, 2016: Advanced Materials
M Snee, M Q Hatton
No abstract text is available yet for this article.
November 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
João S Fernandes, Piergiorgio Gentile, Margarida Martins, Nuno M Neves, Cheryl Miller, Aileen Crawford, Ricardo A Pires, Paul Hatton, Rui L Reis
UNLABELLED: Herein, for the first time, we combined poly-l-lactic acid (PLLA) with a strontium borosilicate bioactive glass (BBG-Sr) using electrospinning to fabricate a composite bioactive PLLA membrane loaded with 10% (w/w) of BBG-Sr glass particles (PLLA-BBG-Sr). The composites were characterised by scanning electron microscopy (SEM) and microcomputer tomography (μ-CT), and the results showed that we successfully fabricated smooth and uniform fibres (1-3μm in width) with a homogeneous distribution of BBG-Sr microparticles (<45μm)...
October 15, 2016: Acta Biomaterialia
Sabrina R Cohen-Hatton, R C Honey
No abstract text is available yet for this article.
August 17, 2016: Learning & Behavior
Eric Emerson, Janet Robertson, Susannah Baines, Chris Hatton
BACKGROUND: Reducing the prevalence of and inequities in the distribution of child obesity will require developing interventions that are sensitive to the situation of 'high risk' groups of children. Children with intellectual disability appear to be one such group. We aimed to estimate the prevalence of obesity in children with and without intellectual disability in a longitudinal representative sample of British children and identify risk factors associated with obesity at age 11. METHODS: Information was collected on a nationally representative sample of over 18,000 at ages 9 months, 3, 5, 7 and 11 years...
2016: BMC Public Health
Andrew R Conery, Richard C Centore, Adrianne Neiss, Patricia J Keller, Shivangi Joshi, Kerry L Spillane, Peter Sandy, Charlie Hatton, Eneida Pardo, Laura Zawadzke, Archana Bommi-Reddy, Karen E Gascoigne, Barbara M Bryant, Jennifer A Mertz, Robert J Sims
No abstract text is available yet for this article.
2016: ELife
Maxwell R Bennett, Sean Hatton, Daniel F Hermens, Jim Lagopoulos
Cognitive neuroscientists in the late 20th century began the task of identifying the part(s) of the brain concerned with normal behavior as manifest in the psychological capacities as affective powers, reasoning, behaving purposively and the pursuit of goals, following introduction of the 'functional magnetic resonance imaging' (fMRI) method for identifying brain activity. For this research program to be successful two questions require satisfactory answers. First, as the fMRI method can currently only be used on stationary subjects, to what extent can neuropsychological tests applicable to such stationary subjects be correlated with normal behavior...
July 5, 2016: Progress in Neurobiology
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