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https://www.readbyqxmd.com/read/28415393/the-relationship-between-particle-morphology-and-rheological-properties-in-injectable-nano-hydroxyapatite-bone-graft-substitutes
#1
Y Ryabenkova, A Pinnock, P A Quadros, R L Goodchild, G Möbus, A Crawford, P V Hatton, C A Miller
Biomaterials composed of hydroxyapatite (HA) are currently used for the treatment of bone defects resulting from trauma or surgery. However, hydroxyapatite supplied in the form of a paste is considered a very convenient medical device compared to the materials where HA powder and liquid need to be mixed immediately prior to the bone treatment during surgery. In this study we have tested a series of hydroxyapatite (HA) pastes with varying microstructure and different rheological behaviour to evaluate their injectability and biocompatibility...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28391653/clinical-case-series-describes-a-contraindication-for-serenocem-granules-%C3%A2-in-mastoid-obliteration-our-experience-in-sixty-four-patients
#2
Laura Harrison, Sonia Kumar, Matthew Bull, Paul V Hatton, Ian Bottrill, Christopher Aldren
Mastoid obliteration has been performed with various materials including muscle, fat, cartilage, musculoperiosteal flaps, chips and pâté(1) . Biocompatible materials used since the 1960s, have a number of potential advantages over autologous tissue. They are sterile, available off the shelf without the need for harvest and have a low risk of implanting cholesteatoma.
April 9, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28369727/n-terminal-or-signal-peptide-sequence-engineering-prevents-truncation-of-human-monoclonal-antibody-light-chains
#3
S J Gibson, N J Bond, S Milne, A Lewis, A Sheriff, G Pettman, R Pradhan, D R Higazi, D Hatton
Monoclonal antibodies (mAbs) contain short N-terminal signal peptides on each individual polypeptide that comprises the mature antibody, targeting them for export from the cell in which they are produced. The signal peptide is cleaved from each heavy chain (Hc) and light chain (Lc) polypeptide after translocation to the ER and prior to secretion. This process is generally highly efficient, producing a high proportion of correctly cleaved Hc and Lc polypeptides. However, mis-cleavage of the signal peptide can occur, resulting in truncation or elongation at the N-terminus of the Hc or Lc...
March 28, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28368439/pembrolizumab-associated-hemophagocytic-lymphohistiocytosis
#4
D Shah, R Shrestha, R Ramlal, J Hatton, H Saeed
No abstract text is available yet for this article.
March 20, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28364595/hippocampal-development-in-youth-with-a-history-of-childhood-maltreatment
#5
Casey Paquola, Maxwell R Bennett, Sean N Hatton, Daniel F Hermens, Inge Groote, Jim Lagopoulos
Childhood maltreatment (CM) is associated with enhanced risk of psychiatric illness and reduced subcortical grey matter in adulthood. The hippocampus and amygdala, due to their involvement in stress and emotion circuitries, have been subject to extensive investigations regarding the effect of CM. However, the complex relationship between CM, subcortical grey matter and mental illness remains poorly understood partially due to a lack of longitudinal studies. Here we used segmentation and linear mixed effect modelling to examine the impact of CM on hippocampal and amygdala development in young people with emerging mental illness...
March 27, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28357562/in-vivo-imaging-of-oxidative-stress-and-fronto-limbic-white-matter-integrity-in-young-adults-with-mood-disorders
#6
Daniel F Hermens, Sean N Hatton, Rico S C Lee, Sharon L Naismith, Shantel L Duffy, G Paul Amminger, Manreena Kaur, Elizabeth M Scott, Jim Lagopoulos, Ian B Hickie
Fronto-limbic connectivity is compromised in mood disorders, as reflected by impairments in white matter (WM) integrity revealed by diffusion tensor imaging. Although the underlying mechanisms remain unclear, disruption to normal myelination due to oxidative stress is thought to play a key role. We aimed to determine whether fronto-limbic WM integrity is compromised, and associated with in vivo antioxidant levels (indexed by glutathione; GSH), in young adults with unipolar depression (DEP) and bipolar (BD) disorders...
March 29, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28346797/substituted-borosilicate-glasses-with-improved-osteogenic-capacity-for-bone-tissue-engineering
#7
João S Fernandes, Piergiorgio Gentile, Aileen Crawford, Ricardo A Pires, Paul V Hatton, Rui L Reis
Borosilicate bioactive glasses (BBGs) have shown the capacity to promote higher formation of new bone when compared with silicate bioactive glasses. Herein, we assessed the capacity of BBGs to induce osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) as a function of their substituted divalent cations (Mg(2+), Ca(2+), Sr(2+)). To this purpose, we synthesized BBG particles by melt quenching. The cell viability, proliferation, and morphology (i.e., PrestoBlue(®), PicoGreen(®), and DAPI and Phalloidin stainings, respectively), as well as protein expression (i...
March 27, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28343931/coronal-and-intraradicular-appearances-affect-radiographic-perception-of-the-periapical-region
#8
Julie W Strong, Karl F Woodmansey, John A Khademi, John F Hatton
INTRODUCTION: The influence of the radiographic appearances of the coronal and intraradicular areas on periapical radiographic interpretation has been minimally evaluated in dentistry and endodontics. The purpose of this study was to evaluate the effects that the coronal and intraradicular radiographic appearance has on endodontists' radiographic interpretations of periapical areas. METHODS: In a split-group study design using an online survey format, 2 pairs of digital periapical radiographic images were evaluated by 2 groups (A and B) of endodontist readers for the presence of a periapical finding...
March 23, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28314943/predicting-hospital-stay-mortality-and-readmission-in-people-admitted-for-hypoglycaemia-prognostic-models-derivation-and-validation
#9
Francesco Zaccardi, David R Webb, Melanie J Davies, Nafeesa N Dhalwani, Laura J Gray, Sudesna Chatterjee, Gemma Housley, Dominick Shaw, James W Hatton, Kamlesh Khunti
AIMS/HYPOTHESIS: Hospital admissions for hypoglycaemia represent a significant burden on individuals with diabetes and have a substantial economic impact on healthcare systems. To date, no prognostic models have been developed to predict outcomes following admission for hypoglycaemia. We aimed to develop and validate prediction models to estimate risk of inpatient death, 24 h discharge and one month readmission in people admitted to hospital for hypoglycaemia. METHODS: We used the Hospital Episode Statistics database, which includes data on all hospital admission to National Health Service hospital trusts in England, to extract admissions for hypoglycaemia between 2010 and 2014...
March 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/28299922/fabrication-of-electrospun-mucoadhesive-membranes-for-therapeutic-applications-in-oral-medicine
#10
Martin E Santocildes-Romero, Lucie Hadley, Katharina H Clitherow, Jens Hansen, Craig Murdoch, Helen E Colley, Martin H Thornhill, Paul V Hatton
Oral mucosal lesions are related to several etiologies, including trauma, infection, and immunologic and neoplastic diseases. Their prevalence varies greatly depending on ethnicity, gender, and exposure to risk factors. Currently, most oral mucosal lesions are treated with creams, mouthwashes, or gels containing suitable drugs. However, topical medications may be relatively ineffective as they are removed rapidly from oral surfaces, limiting drug contact times. Systemic medications might be more effective but are associated with unacceptable off-target side effects...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28295974/risk-factors-and-outcome-differences-in-hypoglycaemia-related-hospital-admissions-a-case-control-study-in-england
#11
Francesco Zaccardi, David R Webb, Melanie J Davies, Nafeesa N Dhalwani, Gemma Housley, Dominic Shaw, James W Hatton, Kamlesh Khunti
AIMS: To evaluate risk factors for hospital admissions for hypoglycaemia and compare length of hospitalisation, inpatient mortality, and hospital readmission between hypoglycaemia and non-hypoglycaemia-related admissions. MATERIALS AND METHODS: We used all admissions for hypoglycaemia in people with diabetes to English NHS hospital trusts between 2005 and 2014 (101,475 case admissions) and three random admissions per case in people with diabetes without hypoglycaemia (304,425 control admissions)...
March 14, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28287572/rapid-mix-preparation-of-bioinspired-nanoscale-hydroxyapatite-for-biomedical-applications
#12
Caroline J Wilcock, Piergiorgio Gentile, Paul V Hatton, Cheryl A Miller
Hydroxyapatite (HA) has been widely used as a medical ceramic due to its good biocompatibility and osteoconductivity. Recently there has been interest regarding the use of bioinspired nanoscale hydroxyapatite (nHA). However, biological apatite is known to be calcium-deficient and carbonate-substituted with a nanoscale platelet-like morphology. Bioinspired nHA has the potential to stimulate optimal bone tissue regeneration due to its similarity to bone and tooth enamel mineral. Many of the methods currently used to fabricate nHA both in the laboratory and commercially, involve lengthy processes and complex equipment...
February 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28286961/people-with-intellectual-disabilities-and-dysphagia
#13
Janet Robertson, Darren Chadwick, Susannah Baines, Eric Emerson, Chris Hatton
PURPOSE: Dysphagia (difficulties in eating, drinking or swallowing) is associated with serious health complications and psychosocial sequelae. This review aims to summarise the state of the evidence regarding dysphagia in people with intellectual disabilities (excluding prevalence), identify gaps in the evidence base and highlight future research priorities. METHOD: Studies published from 1 January 1990 to 19 July 2016 were identified using Medline, Cinahl, PsycINFO, Web of Science, email requests and cross citations...
March 12, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28256777/utility-of-the-cumulative-stress-and-mismatch-hypotheses-in-understanding-the-neurobiological-impacts-of-childhood-abuse-and-recent-stress-in-youth-with-emerging-mental-disorder
#14
Casey Paquola, Maxwell R Bennett, Sean N Hatton, Daniel F Hermens, Jim Lagopoulos
Childhood abuse has an enduring impact on the brain's stress system. Whether the effects of childhood abuse and adulthood stress are additive (cumulative stress hypothesis) or interactive (mismatch hypothesis) is widely disputed, however. The primary aim of this study was to test the utility of the cumulative stress and mismatch hypotheses in understanding brain and behaviour. We recruited 64 individuals (aged 14-26) from a specialised clinic for assessment and early intervention of mental health problems in young people...
March 3, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28253064/effects-of-two-diode-lasers-with-and-without-photosensitization-on-contaminated-implant-surfaces-an-ex-vivo-study
#15
Nicola Alberto Valente, Thomas Mang, Michael Hatton, Lynn Mikulski, Sebastiano Andreana
OBJECTIVE: The aim of this ex vivo study is to assess decontamination potential of two different diode laser wavelengths, with or without the aid of photodynamic therapy, on dental implant surfaces and to evaluate the harmful potential of temperature increase during laser irradiation. MATERIALS AND METHODS: One hundred thirty-two machined sterile implants were placed into sterile porcine bone blocks with standardized coronal angular bony defects and inoculated with Streptococcus sanguinis...
February 16, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28251799/diet-affects-arctic-ground-squirrel-gut-microbial-metatranscriptome-independent-of-community-structure
#16
Jasmine J Hatton, Timothy J Stevenson, C Loren Buck, Khrystyne N Duddleston
We examined the effect of diet on pre-hibernation fattening and the gut microbiota of captive arctic ground squirrels (Urocitellus parryii). We measured body composition across time and gut microbiota density, diversity and function prior to and after five-weeks on control, high-fat, low-fat (18%, 40% and 10% energy from fat, respectively), or restricted calorie (50% of control) diets. Squirrels fattened at the same rate and to the same degree on all diets. Additionally, we found no differences in gut microbiota diversity or short chain fatty acid production across time or with diet...
April 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28244732/postsynthetic-functionalization-of-mg-mof-74-with-tetraethylenepentamine-structural-characterization-and-enhanced-co2-adsorption
#17
Xiao Su, Lev Bromberg, Vladimir Martis, Fritz Simeon, Ashfia Huq, T Alan Hatton
Postsynthetic functionalization of magnesium 2,5-dihydroxyterephthalate (Mg-MOF-74) with tetraethylenepentamine (TEPA) resulted in improved CO2 adsorption performance under dry and humid conditions. XPS, elemental analysis, and neutron powder diffraction studies indicated that TEPA was incorporated throughout the MOF particle, although it coordinated preferentially with the unsaturated metal sites located in the immediate proximity to the surface. Neutron and X-ray powder diffraction analyses showed that the MOF structure was preserved after amine incorporation, with slight changes in the lattice parameters...
March 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28242876/rapid-adaptation-to-microgravity-in-mammalian-macrophage-cells
#18
Cora S Thiel, Diane de Zélicourt, Svantje Tauber, Astrid Adrian, Markus Franz, Dana M Simmet, Kathrin Schoppmann, Swantje Hauschild, Sonja Krammer, Miriam Christen, Gesine Bradacs, Katrin Paulsen, Susanne A Wolf, Markus Braun, Jason Hatton, Vartan Kurtcuoglu, Stefanie Franke, Samuel Tanner, Samantha Cristoforetti, Beate Sick, Bertold Hock, Oliver Ullrich
Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the cellular capacity for adaptation to a new gravitational environment. The International Space Station (ISS) experiment TRIPLE LUX A, performed in the BIOLAB laboratory of the ISS COLUMBUS module, allowed for the first time the direct measurement of a cellular function in real time and on orbit. We measured the oxidative burst reaction in mammalian macrophages (NR8383 rat alveolar macrophages) exposed to a centrifuge regime of internal 0 g and 1 g controls and step-wise increase or decrease of the gravitational force in four independent experiments...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210826/stranger-fear-and-early-risk-for-social-anxiety-in-preschoolers-with-fragile-x-syndrome-contrasted-to-autism-spectrum-disorder
#19
Jessica F Scherr, Abigail L Hogan, Deborah Hatton, Jane E Roberts
This study investigated behavioral indicators of social fear in preschool boys with fragile X syndrome (FXS) with a low degree of autism spectrum disorder (ASD) symptoms (FXS-Low; n = 29), FXS with elevated ASD symptoms (FXS-High; n = 25), idiopathic ASD (iASD; n = 11), and typical development (TD; n = 36). Gaze avoidance, escape behaviors, and facial fear during a stranger approach were coded. Boys with elevated ASD symptoms displayed more avoidant gaze, looking less at the stranger and parent than those with low ASD symptoms across etiologies...
February 16, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28173638/valproate-protein-binding-is-highly-variable-in-icu-patients-and-not-predicted-by-total-serum-concentrations-a-case-series-and-literature-review
#20
Richard R Riker, David J Gagnon, Colman Hatton, Teresa May, David B Seder, Katie Stokem, Gilles L Fraser
STUDY OBJECTIVE: The free fraction of valproate (the pharmacologically active moiety, normally 5-10%) may vary significantly in critically ill patients, but this topic is understudied, with only four prior intensive care unit (ICU) case reports. The objective of this study was to evaluate the range of valproate plasma protein binding in ICU patients. DESIGN: Observational study of consecutive ICU patients. SETTING: Neurocritical and medical critical care services in a nonuniversity academic medical center...
April 2017: Pharmacotherapy
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