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https://www.readbyqxmd.com/read/28314943/predicting-hospital-stay-mortality-and-readmission-in-people-admitted-for-hypoglycaemia-prognostic-models-derivation-and-validation
#1
Francesco Zaccardi, David R Webb, Melanie J Davies, Nafeesa N Dhalwani, Laura J Gray, Sudesna Chatterjee, Gemma Housley, Dominick Shaw, James W Hatton, Kamlesh Khunti
AIMS/HYPOTHESIS: Hospital admissions for hypoglycaemia represent a significant burden on individuals with diabetes and have a substantial economic impact on healthcare systems. To date, no prognostic models have been developed to predict outcomes following admission for hypoglycaemia. We aimed to develop and validate prediction models to estimate risk of inpatient death, 24 h discharge and one month readmission in people admitted to hospital for hypoglycaemia. METHODS: We used the Hospital Episode Statistics database, which includes data on all hospital admission to National Health Service hospital trusts in England, to extract admissions for hypoglycaemia between 2010 and 2014...
March 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/28299922/fabrication-of-electrospun-mucoadhesive-membranes-for-therapeutic-applications-in-oral-medicine
#2
Martin E Santocildes-Romero, Lucie Hadley, Katharina H Clitherow, Jens Hansen, Craig Murdoch, Helen E Colley, Martin Thornhill, Paul V Hatton
Oral mucosal lesions are related to several etiologies including trauma, infection, and immunologic and neoplastic diseases. Their prevalence varies greatly depending on ethnicity, gender and exposure to risk factors. Currently, most oral mucosal lesions are treated with creams, mouthwashes or gels containing suitable drugs. However, topical medications may be relatively ineffective as they are removed rapidly from oral surfaces, limiting drug contact times. Systemic medications might be more effective, but are associated with unacceptable off-target side effects...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28295974/risk-factors-and-outcome-differences-in-hypoglycaemia-related-hospital-admissions-a-case-control-study-in-england
#3
Francesco Zaccardi, David R Webb, Melanie J Davies, Nafeesa N Dhalwani, Gemma Housley, Dominic Shaw, James W Hatton, Kamlesh Khunti
AIMS: To evaluate risk factors for hospital admissions for hypoglycaemia and compare length of hospitalisation, inpatient mortality, and hospital readmission between hypoglycaemia and non-hypoglycaemia-related admissions. MATERIALS AND METHODS: We used all admissions for hypoglycaemia in people with diabetes to English NHS hospital trusts between 2005 and 2014 (101,475 case admissions) and three random admissions per case in people with diabetes without hypoglycaemia (304,425 control admissions)...
March 14, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28287572/rapid-mix-preparation-of-bioinspired-nanoscale-hydroxyapatite-for-biomedical-applications
#4
Caroline J Wilcock, Piergiorgio Gentile, Paul V Hatton, Cheryl A Miller
Hydroxyapatite (HA) has been widely used as a medical ceramic due to its good biocompatibility and osteoconductivity. Recently there has been interest regarding the use of bioinspired nanoscale hydroxyapatite (nHA). However, biological apatite is known to be calcium-deficient and carbonate-substituted with a nanoscale platelet-like morphology. Bioinspired nHA has the potential to stimulate optimal bone tissue regeneration due to its similarity to bone and tooth enamel mineral. Many of the methods currently used to fabricate nHA both in the laboratory and commercially, involve lengthy processes and complex equipment...
February 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28286961/people-with-intellectual-disabilities-and-dysphagia
#5
Janet Robertson, Darren Chadwick, Susannah Baines, Eric Emerson, Chris Hatton
PURPOSE: Dysphagia (difficulties in eating, drinking or swallowing) is associated with serious health complications and psychosocial sequelae. This review aims to summarise the state of the evidence regarding dysphagia in people with intellectual disabilities (excluding prevalence), identify gaps in the evidence base and highlight future research priorities. METHOD: Studies published from 1 January 1990 to 19 July 2016 were identified using Medline, Cinahl, PsycINFO, Web of Science, email requests and cross citations...
March 12, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28256777/utility-of-the-cumulative-stress-and-mismatch-hypotheses-in-understanding-the-neurobiological-impacts-of-childhood-abuse-and-recent-stress-in-youth-with-emerging-mental-disorder
#6
Casey Paquola, Maxwell R Bennett, Sean N Hatton, Daniel F Hermens, Jim Lagopoulos
Childhood abuse has an enduring impact on the brain's stress system. Whether the effects of childhood abuse and adulthood stress are additive (cumulative stress hypothesis) or interactive (mismatch hypothesis) is widely disputed, however. The primary aim of this study was to test the utility of the cumulative stress and mismatch hypotheses in understanding brain and behaviour. We recruited 64 individuals (aged 14-26) from a specialised clinic for assessment and early intervention of mental health problems in young people...
March 3, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28253064/effects-of-two-diode-lasers-with-and-without-photosensitization-on-contaminated-implant-surfaces-an-ex-vivo-study
#7
Nicola Alberto Valente, Thomas Mang, Michael Hatton, Lynn Mikulski, Sebastiano Andreana
OBJECTIVE: The aim of this ex vivo study is to assess decontamination potential of two different diode laser wavelengths, with or without the aid of photodynamic therapy, on dental implant surfaces and to evaluate the harmful potential of temperature increase during laser irradiation. MATERIALS AND METHODS: One hundred thirty-two machined sterile implants were placed into sterile porcine bone blocks with standardized coronal angular bony defects and inoculated with Streptococcus sanguinis...
February 16, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28251799/diet-affects-arctic-ground-squirrel-gut-microbial-metatranscriptome-independent-of-community-structure
#8
Jasmine J Hatton, Timothy J Stevenson, C Loren Buck, Khrystyne N Duddleston
We examined the effect of diet on pre-hibernation fattening and the gut microbiota of captive arctic ground squirrels (Urocitellus parryii). We measured body composition across time and gut microbiota density, diversity, and function prior to and after five-weeks on control, high-fat, low-fat (18%, 40%, and 10% energy from fat, respectively), or restricted calorie (50% of control) diets. Squirrels fattened at the same rate and to the same degree on all diets. Additionally, we found no differences in gut microbiota diversity or short chain fatty acid production across time or with diet...
March 2, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28244732/post-synthetic-functionalization-of-mg-mof-74-with-tetraethylenepentamine-structural-characterization-and-enhanced-co2-adsorption
#9
Xiao Su, Lev Bromberg, Vladimir Martis, Fritz Simeon, Ashfia Huq, T Alan Hatton
Post-synthetic functionalization of magnesium 2,5-dihydroxyterephthalate (Mg-MOF-74) with tetraethylenepentamine (TEPA) resulted in improved CO2 adsorption performance under dry and humid conditions. XPS, elemental analysis and neutron powder diffraction studies indicated that TEPA was incorporated throughout the MOF particle, although it coordinated preferentially with the unsaturated metal sites located in the immediate proximity of the surface. Neutron and X-ray powder diffraction analyses showed that the MOF-structure was preserved after amine incorporation, with slight changes in the lattice parameters...
February 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28242876/rapid-adaptation-to-microgravity-in-mammalian-macrophage-cells
#10
Cora S Thiel, Diane de Zélicourt, Svantje Tauber, Astrid Adrian, Markus Franz, Dana M Simmet, Kathrin Schoppmann, Swantje Hauschild, Sonja Krammer, Miriam Christen, Gesine Bradacs, Katrin Paulsen, Susanne A Wolf, Markus Braun, Jason Hatton, Vartan Kurtcuoglu, Stefanie Franke, Samuel Tanner, Samantha Cristoforetti, Beate Sick, Bertold Hock, Oliver Ullrich
Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the cellular capacity for adaptation to a new gravitational environment. The International Space Station (ISS) experiment TRIPLE LUX A, performed in the BIOLAB laboratory of the ISS COLUMBUS module, allowed for the first time the direct measurement of a cellular function in real time and on orbit. We measured the oxidative burst reaction in mammalian macrophages (NR8383 rat alveolar macrophages) exposed to a centrifuge regime of internal 0 g and 1 g controls and step-wise increase or decrease of the gravitational force in four independent experiments...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210826/stranger-fear-and-early-risk-for-social-anxiety-in-preschoolers-with-fragile-x-syndrome-contrasted-to-autism-spectrum-disorder
#11
Jessica F Scherr, Abigail L Hogan, Deborah Hatton, Jane E Roberts
This study investigated behavioral indicators of social fear in preschool boys with fragile X syndrome (FXS) with a low degree of autism spectrum disorder (ASD) symptoms (FXS-Low; n = 29), FXS with elevated ASD symptoms (FXS-High; n = 25), idiopathic ASD (iASD; n = 11), and typical development (TD; n = 36). Gaze avoidance, escape behaviors, and facial fear during a stranger approach were coded. Boys with elevated ASD symptoms displayed more avoidant gaze, looking less at the stranger and parent than those with low ASD symptoms across etiologies...
February 16, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28173638/valproate-protein-binding-is-highly-variable-in-icu-patients-and-not-predicted-by-total-serum-concentrations-a-case-series-and-literature-review
#12
Richard R Riker, David J Gagnon, Colman Hatton, Teresa May, David B Seder, Katie Stokem, Gilles L Fraser
STUDY OBJECTIVE: The free fraction of valproate (the pharmacologically active moiety, normally 5-10%) may vary significantly in critically ill patients, but this topic is understudied, with only 4 prior ICU case reports. The objective of this study was to evaluate the range of valproate plasma protein binding in ICU patients. DESIGN: Observational study of consecutive ICU patients. SETTING: Neurocritical and medical critical care services in a non-university academic medical center...
February 7, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28169513/multilayer-nanoscale-encapsulation-of-biofunctional-peptides-to-enhance-bone-tissue-regeneration-in-vivo
#13
Piergiorgio Gentile, Ana Marina Ferreira, Jill T Callaghan, Cheryl A Miller, Joss Atkinson, Christine Freeman, Paul V Hatton
Bone tissue healing is a dynamic process that is initiated by the recruitment of osteoprogenitor cells followed by their migration, proliferation, differentiation, and development of a mineralizing extracellular matrix. The work aims to manufacture a functionalized porous membrane that stimulates early events in bone healing for initiating a regenerative cascade. Layer-by-layer (LbL) assembly is proposed to modify the surface of osteoconductive electrospun meshes, based on poly(lactic-co-glycolic acid) and nanohydroxyapatite, by using poly(allylamine hydrochloride) and poly(sodium 4-styrenesulfonate) as polyelectrolytes...
February 7, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28161562/hindrance-of-1-4-dioxane-biodegradation-in-microcosms-biostimulated-with-inducing-or-non-inducing-auxiliary-substrates
#14
Mengyan Li, Yuanyuan Liu, Ya He, Jacques Mathieu, James Hatton, William DiGuiseppi, Pedro J J Alvarez
A microcosm study was conducted to assess two biostimulation strategies (relative to natural attenuation) to bioremediate 1,4-dioxane contamination at a site in west Texas. Dioxane concentrations were relatively low (<300 μg/L), which represents a potential challenge to sustain and induce specific degraders. Thus, biostimulation was attempted with an auxiliary substrate known to induce dioxane-degrading monooxygenases (i.e., tetrahydrohyran [THF]) or with a non-inducing growth substrate (1-butanol [1-BuOH])...
January 26, 2017: Water Research
https://www.readbyqxmd.com/read/28130326/engineering-the-expression-of-an-anti-interleukin-13-antibody-through-rational-design-and-mutagenesis
#15
Bojana Popovic, Suzanne Gibson, Tarik Senussi, Sara Carmen, Sara Kidd, Tim Slidel, Ian Strickland, Xu Jianqing, Jennifer Spooner, Amanda Lewis, Nathan Hudson, Lorna Mackenzie, Jennifer Keen, Ben Kemp, Colin Hardman, Diane Hatton, Trevor Wilkinson, Tristan Vaughan, David Lowe
High levels of protein expression are key to the successful development and manufacture of a therapeutic antibody. Here, we describe two related antibodies, Ab001 and Ab008, where Ab001 shows a markedly lower level of expression relative to Ab008 when stably expressed in Chinese hamster ovary cells. We use single-gene expression vectors and structural analysis to show that the reduced titer is associated with the VL CDR2 of Ab001. We adopted two approaches to improve the expression of Ab001. First, we used mutagenesis to change single amino-acid residues in the Ab001 VL back to the equivalent Ab008 residues but this resulted in limited improvements in expression...
January 26, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/28126393/cross-linked-pluronic-g-polyacrylic-acid-microgel-system-for-the-controlled-release-of-doxorubicin-in-pharmaceutical-formulations
#16
Y Tian, N Grishkewich, L Bromberg, T Alan Hatton, Kam C Tam
The binding of doxorubicin (DOX) to cross-linked Pluronic F127-g-PAA-EGDMA and L92-g-PAA-EGDMA microgels at different alpha (α) and salt concentrations was investigated using isothermal titration calorimetric (ITC), optical and scanning electron microscopic techniques (SEM). We seek to elucidate the mechanisms of interaction and the release of DOX from cross-linked microgels composed of Pluronic and poly(acrylic acid). The ITC results indicated a high binding affinity of DOX to the microgel, which is a function of salt concentrations due to the impact of electrostatic shielding on the DOX-binding process...
January 23, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28098502/united-kingdom-national-paediatric-bilateral-project-results-of-professional-rating-scales-and-parent-questionnaires
#17
H E Cullington, D Bele, J C Brinton, S Cooper, M Daft, J Harding, N Hatton, J Humphries, M E Lutman, J Maddocks, J Maggs, K Millward, G O'Donoghue, S Patel, K Rajput, V Salmon, T Sear, A Speers, A Wheeler, K Wilson
OBJECTIVES: This fourteen-centre project used professional rating scales and parent questionnaires to assess longitudinal outcomes in a large non-selected population of children receiving simultaneous and sequential bilateral cochlear implants. METHODS: This was an observational non-randomized service evaluation. Data were collected at four time points: before bilateral cochlear implants or before the sequential implant, one year, two years, and three years after...
January 18, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28047236/we-ab-202-07-ventilation-ct-voxel-level-comparison-with-hyperpolarized-helium-3-xenon-129-mri
#18
B Tahir, H Marshall, P Hughes, N Stewart, F Horn, G Collier, G Norquay, K Hart, J Swinscoe, M Hatton, J Wild, R Ireland
PURPOSE: To compare the spatial correlation of ventilation surrogates computed from inspiratory and expiratory breath-hold CT with hyperpolarized Helium-3 & Xenon-129 MRI in a cohort of lung cancer patients. METHODS: 5 patients underwent expiration & inspiration breath-hold CT. Xenon-129 & (1) H MRI were also acquired at the same inflation state as inspiratory CT. This was followed immediately by acquisition of Helium-3 & (1) H MRI in the same breath and at the same inflation state as inspiratory CT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032374/heritability-of-white-matter-microstructure-in-late-middle-age-a-twin-study-of-tract-based-fractional-anisotropy-and-absolute-diffusivity-indices
#19
Eero Vuoksimaa, Matthew S Panizzon, Donald J Hagler, Sean N Hatton, Christine Fennema-Notestine, Daniel Rinker, Lisa T Eyler, Carol E Franz, Michael J Lyons, Michael C Neale, Ming T Tsuang, Anders M Dale, William S Kremen
There is evidence that differences among individuals in white matter microstructure, as measured with diffusion tensor imaging (DTI), are under genetic control. However, little is known about the relative contribution of genetic and environmental effects on different diffusivity indices among late middle-aged adults. Here, we examined the magnitude of genetic influences for fractional anisotropy (FA), and mean (MD), axial (AD), and radial (RD) diffusivities in male twins aged 56-66 years old. Using an atlas-based registration approach to delineate individual white matter tracts, we investigated mean DTI-based indices within the corpus callosum, 12 bilateral tracts and all these regions of interest combined...
April 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28025302/micromechanics-of-sea-ice-frictional-slip-from-test-basin-scale-experiments
#20
Peter R Sammonds, Daniel C Hatton, Daniel L Feltham
We have conducted a series of high-resolution friction experiments on large floating saline ice floes in an environmental test basin. In these experiments, a central ice floe was pushed between two other floes, sliding along two interfacial faults. The frictional motion was predominantly stick-slip. Shear stresses, normal stresses, local strains and slip displacement were measured along the sliding faults, and acoustic emissions were monitored. High-resolution measurements during a single stick-slip cycle at several positions along the fault allowed us to identify two phases of frictional slip: a nucleation phase, where a nucleation zone begins to slip before the rest of the fault, and a propagation phase when the entire fault is slipping...
February 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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