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Denise H Rhoney, Kathryn Morbitzer, Jimmi Hatton-Kolpek
Drug dosing in neurocritically ill patients presents enormous challenges for clinicians due to the complex pathophysiological alterations. These alterations are dynamic both between and within patients. Unpredictable exposure from standard dosing regimens, which were extrapolated to intensive care unit patients from healthy volunteer studies, may influence medication outcomes. Knowledge of potential alterations in pharmacokinetics/pharmacodynamics in these patients could be applied to maximize the clinical response and minimize adverse effects...
December 2016: Seminars in Neurology
Brian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, Paul Labhart, Gulfem D Guler, David Arnott, Tobias M Maile, Jennifer Busby, Chisato Henry, Theresa K Kelly, Charles A Tindell, Suchit Jhunjhunwala, Feng Zhao, Charlie Hatton, Barbara M Bryant, Marie Classon, Patrick Trojer
Chromatin immunoprecipitation and DNA sequencing (ChIP-seq) has been instrumental in inferring the roles of histone post-translational modifications in the regulation of transcription, chromatin compaction and other cellular processes that require modulation of chromatin structure. However, analysis of ChIP-seq data is challenging when the manipulation of a chromatin-modifying enzyme significantly affects global levels of histone post-translational modifications. For example, small molecule inhibition of the methyltransferase EZH2 reduces global levels of histone H3 lysine 27 trimethylation (H3K27me3)...
2016: PloS One
Maxwell R Bennett, Jonathon Arnold, Sean N Hatton, Jim Lagopoulos
The extinction of a conditioned fear response is of great interest in the search for a means of ameliorating adverse neurobiological changes resulting from stress. The discovery that endocannibinoid (EC) levels are inversely related to the extent of such stress, and that the amygdala is a primary site mediating stress, suggests that ECs in this brain region might play a major role in extinction. Supporting this are the observations that the basolateral complex of the amygdala shows an increase in ECs only during extinction and that early clinical trials indicate that cannabinoid-like agents, when taken orally by patients suffering from post traumatic stress disorder (PTSD), reduce insomnia and nightmares...
November 17, 2016: Behavioural Brain Research
Anna L Hatton, Kay M Crossley, Ross A Clark, Timothy S Whitehead, Hayden G Morris, Adam G Culvenor
Following anterior cruciate ligament (ACL) rupture, reconstructive surgery (ALCR) is often performed to mechanically stabilise the knee, however functional deficits often persist long after surgery. Impaired single-limb standing balance has been observed in the ACLR limb compared to healthy individuals. However, it remains inconclusive as to whether these same balance deficits exist between the injured and contralateral uninjured limbs, during challenging balance tasks, and at a time when patients are permitted to return to sport...
November 11, 2016: Gait & Posture
Jeremy Flynn, Alexander Flannery, Kevin Hatton
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Richard Riker, David Gagnon, Colman Hatton, Katie Stokem, Gilles Fraser
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Joanne S Carpenter, Amy C Abelmann, Sean N Hatton, Rébecca Robillard, Daniel F Hermens, Maxwell R Bennett, Jim Lagopoulos, Ian B Hickie
Affective disorders in young people have been associated with disruptions in circadian rhythms, including abnormalities in secretion of the pineal hormone melatonin. Previous research reports relationships between pineal gland volumes, melatonin secretion, and sleep-wake cycles, but the relationship between these factors has not been explored in affective disorders. This study aimed to characterize these factors and explore associations with mood symptoms and functioning in a sample of young people with affective disorders...
November 3, 2016: Brain Imaging and Behavior
Katie Bardsley, Agnieska Kwarciak, Christine Freeman, Ian Brook, Paul Hatton, Aileen Crawford
The regeneration of large bone defects remains clinically challenging. The aim of our study was to use a rat model to use nasal chondrocytes to engineer a hypertrophic cartilage tissue which could be remodelled into bone in vivo by endochondral ossification. Primary adult rat nasal chondrocytes were isolated from the nasal septum, the cell numbers expanded in monolayer culture and the cells cultured in vitro on polyglycolic acid scaffolds in chondrogenic medium for culture periods of 5-10 weeks. Hypertrophic differentiation was assessed by determining the temporal expression of key marker genes and proteins involved in hypertrophic cartilage formation...
October 11, 2016: Biomaterials
Tracy Hatton, Eleanor Grimshaw, John Vargo, Erica Seville
Business Continuity Planning (BCP) is well established as a key plank in an organisation's risk management process. But how effective is BCP when disaster strikes? This paper examines the experiences of organisations following the 2010-11 Canterbury, New Zealand earthquakes. The study finds that BCP was helpful for all organisations interviewed but more attention is needed on the management of societal and personal impacts; development of employee resilience, identification of effective crisis leaders; right-sizing plans and planning to seize opportunities post-disaster...
2016: Journal of Business Continuity & Emergency Planning
Ankur Gupta, Vivek Narsimhan, T Alan Hatton, Patrick S Doyle
The evolution of droplet size during nanoemulsion formation is critical for the ra- tional design of nanoemulsions in areas such as drug delivery and materials synthesis. In this article, we discuss the relative importance of various time scales involved in nanoemulsion formation and propose a population balance model for droplet breakup that takes into account the droplet's internal viscosity. The proposed model gives a qualitative agreement with average droplet size and polydispersity data for nanoemul- sions prepared by high pressure homogenization and ultrasonication...
October 11, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Mélanie Faria da Cunha, Juliette Simonin, Ali Sassi, Romain Freund, Aurélie Hatton, Charles-Henry Cottart, Nadia Elganfoud, Rachid Zoubairi, Corina Dragu, Jean Philippe Jais, Alexandre Hinzpeter, Aleksander Edelman, Isabelle Sermet-Gaudelus
The nasal epithelium of the mouse closely mimics the bioelectrical phenotype of the human airways. Ion transport across the nasal epithelium induces a nasal transepithelial potential difference. Its measurement by a relatively non-invasive method adapted from humans allows in vivo longitudinal measurements of CFTR-dependent ionic transport in the murine nasal mucosa. This test offers a useful tool to assess CFTR function in preclinical studies for novel therapeutics modulating CFTR activity. Here we extensively review work done to assess transepithelial transport in the murine respiratory epithelium in the basal state and after administration of CFTR modulators...
November 2016: International Journal of Biochemistry & Cell Biology
Xiao Su, T Alan Hatton
Redox-active materials hold great promise as platforms for selective liquid-phase separations. In contrast to capacitive electrodes that rely purely on double-layer charge for deionization, redox-modified electrodes can be used to control Faradaic reactions at the interface to selectively bind various charged and uncharged molecules, thus modulating surface interactions through electrochemical potential solely. These electrodes can be composed of a range of functional materials, from organic and organometallic polymers to inorganic crystalline compounds, each relying on its own distinct ion-exchange process...
September 9, 2016: Advances in Colloid and Interface Science
Demetra S Achilleos, T Alan Hatton
We report the development of a dual-electrode Pseudocapacitive Separation Technology (PSST) to capture quantitatively, remotely, and in a reversible manner, value-added carboxylate salts of environmental and industrial significance. The nanostructured pseudocapacitive cell exhibits elegant molecular selectivity towards ionic species: upon electrochemical oxidation, a poly(vinyl ferrocene) (PVF)-based anodic electrode shows high selectivity towards carboxylates based on their basicity and hydrophobicity. Simultaneously, on the other side of the electrochemical cell, a poly(anthraquinone) (PAQ)-based cathodic electrode undergoes electrochemical reduction and captures the counterions of these carboxylates...
October 4, 2016: ACS Applied Materials & Interfaces
B J Slotman, C Faivre-Finn, H van Tinteren, A Keijser, J O Praag, J Knegjens, M Hatton, I van Dam, A van der Leest, B Reymen, J Stigt, K Haslett, D Tripathi, E Smit, S Senan
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Myriam Mesbahi, Michal Shteinberg, Michael Wilschanski, Aurelie Hatton, Thao Nguyen-Khoa, Hannah Friedman, Michael Cohen, Virginie Escabasse, Muriel Le Bourgeois, Vicenzina Lucidi, Isabelle Sermet-Gaudelus, Laurence Bassinet, Galit Livnat
Ivacaftor, a CFTR potentiator, has been found to improve CFTR function and clinical outcomes in patients with cystic fibrosis (CF) gating mutations. We investigated the effects of ivacaftor on CFTR functional measurement in CF patients carrying gating mutations other than p.Gly551Asp. Two siblings aged 13 and 12 carrying the p.Ser549Asn mutation, two sisters (45 and 43years old) compound heterozygotes for p.Asp1152His and p.Gly1244Glu, a 37year old man homozygous for the p.Gly1244Glu mutation, and a 7year old girl with p...
September 19, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Anna L Hatton, François Hug, Sarah H Chen, Christine Reid, Nicole A Sorensen, Kylie Tucker
Middle-aged adults with painful hip conditions show balance impairments that are consistent with an increased risk of falls. Pathological changes at the hip, accompanied by pain, may accelerate pre-existing age-related balance deficits present in midlife. To consider the influence of pain alone, we investigated the effects of acute experimental hip muscle pain on dynamic single-limb balance in middle-aged adults. Thirty-four healthy adults aged 40-60 years formed two groups (Group-1: n=16; Group-2: n=18). Participants performed four tasks: Reactive Sideways Stepping (ReactSide); Star Excursion Balance Test (SEBT); Step Test; Single-Limb Squat; before and after an injection of hypertonic saline into the right gluteus medius muscle (Group-1) or ∼5min rest (Group-2)...
October 2016: Gait & Posture
Barbara C Cahill, Nathan D Hatton, John J Ryan
No abstract text is available yet for this article.
August 17, 2016: Journal of Heart and Lung Transplantation
R H Ireland, B A Tahir, J M Wild, C E Lee, M Q Hatton
For patients with lung cancer undergoing curative intent radiotherapy, functional lung imaging can be incorporated into treatment planning to modify the dose distribution within non-target volume lung by differentiation of lung regions that are functionally defective or viable. This concept of functional image-guided lung avoidance treatment planning has been investigated with several imaging modalities, primarily single photon emission computed tomography (SPECT), but also hyperpolarised gas magnetic resonance (MR) imaging, positron emission tomography (PET) and computed tomography (CT)-based measures of lung biomechanics...
November 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
Hari Katepalli, Arijit Bose, T Alan Hatton, Daniel Blankschtein
We investigate the use of particle hydrophilicity as a tool for emulsion destabilization in Triton-X-100-stabilized hexadecane-in-water emulsions. The hydrophilicity of the particles added to the aqueous phase was found to have a pronounced effect on the stability of the emulsion. Specifically, the addition of hydrophilic fumed silica particles to the aqueous phase resulted in coarsening of the emulsion droplets, with droplet flocculation observed at higher particle concentrations. On the other hand, when partially hydrophobic fumed silica particles were added to the aqueous phase, coarsening of the emulsion droplets was observed at low particle concentrations and phase separation of oil and water was observed at higher particle concentrations...
October 5, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
E Emerson, J Robertson, S Baines, C Hatton
BACKGROUND: Reducing harmful levels of alcohol consumption among children is an important public health concern internationally and in many high income countries. Little is known about levels and predictors of alcohol use among children with intellectual disability (ID). METHOD: Secondary analysis of child self-report data at age 11 years collected in the UK's Millennium Cohort Study. RESULTS: Children with ID were significantly more likely to: have used alcohol in the last 4 weeks; to have had five or more alcoholic drinks on one occasion; to have had five or more alcoholic drinks or been intoxicated on one occasion; to have more positive attitudes about the psychological and social benefits of drinking; and to have less negative attitudes about the social and physical costs of drinking...
September 1, 2016: Journal of Intellectual Disability Research: JIDR
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