Read by QxMD icon Read


Brian P Hermanson, Grant C Burgdorf, John F Hatton, Darrin M Speegle, Karl F Woodmansey
INTRODUCTION: The visual search patterns of dentists and the areas that attract their attention when interpreting dental periapical radiographs are currently unknown. This research identifies areas and patterns of visual fixation when observing dental periapical radiographs. METHODS: In an observational study using eye tracking technology and a convenience sample of 44 observers, the interpretations of 4 dental periapical radiographs were recorded using Camtasia Software (TechSmith, Okemos, MI) with a gaze tracking "bubble" denoting where within the radiograph the observers' eyes gazed...
March 15, 2018: Journal of Endodontics
Lucas Hidalgo Pitaluga, Marina Trevelin Souza, Edgar Dutra Zanotto, Martin Eduardo Santocildes Romero, Paul V Hatton
Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their regenerative potential. Here, the manufacturing of composite electrospun membranes made of poly (ε-caprolactone) (PCL) and particles of a novel bioactive glass composition (F18) is described. The membranes were mechanically and biologically tested with tensile strength tests and tissue culture with MG-63 osteoblast-like cell line, respectively...
March 8, 2018: Materials
Tamara S Hannon, Lisa G Yazel-Smith, Amy S Hatton, Jennifer L Stanton, Elizabeth A S Moser, Xiaochun Li, Aaron E Carroll
BACKGROUND: As adolescents gain autonomy, it remains important for parents to be involved with diabetes management to avoid deterioration in glycemic control. Technologies for self-monitoring of blood glucose (SMBG) allow for remote monitoring in real-time by parents. This research compared 3 strategies for improving SMBG and diabetes self-care in the short-term. These strategies were: (1) health information technology (HIT)-enhanced blood glucose meter that shared blood glucose data among patients, their parent, and care providers, and allowed for text messaging; (2) family-centered goal setting; and (3) a combination of (1) and (2)...
March 4, 2018: Pediatric Diabetes
Neil J Stewart, Ho-Fung Chan, Paul J C Hughes, Felix C Horn, Graham Norquay, Madhwesha Rao, Denise P Yates, Rob H Ireland, Matthew Q Hatton, Bilal A Tahir, Paul Ford, Andrew J Swift, Rod Lawson, Helen Marshall, Guilhem J Collier, Jim M Wild
BACKGROUND: To support translational lung MRI research with hyperpolarized129 Xe gas, comprehensive evaluation of derived quantitative lung function measures against established measures from3 He MRI is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability of129 Xe functional metrics have not been reported. PURPOSE/HYPOTHESIS: To compare hyperpolarized129 Xe and3 He MRI-derived quantitative metrics of lung ventilation and microstructure, and their repeatability, at 1...
March 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
Iwona Pranke, Laure Bidou, Natacha Martin, Sandra Blanchet, Aurélie Hatton, Sabrina Karri, David Cornu, Bruno Costes, Benoit Chevalier, Danielle Tondelier, Emmanuelle Girodon, Matthieu Coupet, Aleksander Edelman, Pascale Fanen, Olivier Namy, Isabelle Sermet-Gaudelus, Alexandre Hinzpeter
Premature termination codons (PTCs) are generally associated with severe forms of genetic diseases. Readthrough of in-frame PTCs using small molecules is a promising therapeutic approach. Nonetheless, the outcome of preclinical studies has been low and variable. Treatment efficacy depends on: 1) the level of drug-induced readthrough, 2) the amount of target transcripts, and 3) the activity of the recoded protein. The aim of the present study was to identify, in the cystic fibrosis transmembrane conductance regulator (CFTR) model, recoded channels from readthrough therapy that may be enhanced using CFTR modulators...
January 2018: ERJ Open Research
Linda K McEvoy, Christine Fennema-Notestine, Jeremy A Elman, Lisa T Eyler, Carol E Franz, Donald J Hagler, Sean N Hatton, Michael J Lyons, Matthew S Panizzon, Anders M Dale, William S Kremen
Heavy alcohol consumption is associated with deleterious changes in the brain but associations of moderate alcohol intake are not well understood. We examined the association of alcohol consumption with brain white matter health in 377 middle-aged men (56-66 years old; mean 61.8 ± 2.6 years) who were participants in the Vietnam Era Twin Study of Aging (VETSA). T1-, T2-, proton density-, and diffusion-weighted magnetic resonance images were obtained. Diffusion measures were quantified from 12 major white matter tracts...
2018: NeuroImage: Clinical
Mark W Logue, Matthew S Panizzon, Jeremy A Elman, Nathan A Gillespie, Sean N Hatton, Daniel E Gustavson, Ole A Andreassen, Anders M Dale, Carol E Franz, Michael J Lyons, Michael C Neale, Chandra A Reynolds, Xin Tu, William S Kremen
Early identification of younger, non-demented adults at elevated risk for Alzheimer's disease (AD) is crucial because the pathological process begins decades before dementia onset. Toward that end, we showed that an AD polygenic risk score (PRS) could identify mild cognitive impairment (MCI) in adults who were only in their 50s. Participants were 1176 white, non-Hispanic community-dwelling men of European ancestry in the Vietnam Era Twin Study of Aging (VETSA): 7% with amnestic MCI (aMCI); 4% with non-amnestic MCI (naMCI)...
February 27, 2018: Molecular Psychiatry
Rosalind E M Hatton, Maria Gardani
OBJECTIVES: Parental knowledge on sleep hygiene in children may be a contributing factor for sleep difficulties in preschoolers. As sleep is crucial for healthy development, it is important to understand how parental knowledge can be improved. The aim of this qualitative study was to develop an understanding of advice available in the United Kingdom (UK) on sleep in young children. DESIGN: This study employed constructivist grounded theory methodology. METHODS: Participants were recruited via social media and a previously constructed participant database...
February 27, 2018: British Journal of Health Psychology
Marissa Robinson, Jessica Klusek, Michele D Poe, Deborah D Hatton, Jane E Roberts
Effortful control, or the ability to suppress a dominant response to perform a subdominant response, is an early-emerging temperament trait that is linked with positive social-emotional development. Fragile X syndrome (FXS) is a single-gene disorder characterized by hallmark regulatory impairments, suggesting diminished effortful control. This study compared the development of effortful control in preschool boys with FXS ( n = 97) and typical development ( n = 32). Unlike their typical peers, the boys with FXS did not exhibit growth in effortful control over time, which could not be accounted for by adaptive impairments, FMR1 molecular measures, or autism symptoms...
March 2018: American Journal on Intellectual and Developmental Disabilities
Eric Emerson, Chris Hatton, Janet Robertson, Susannah Baines
We sought to investigate the association between employment conditions and health among working age British adults with and without intellectual impairments. Using data from the 1970 British Cohort Study, we undertook a series of cross sectional analyses of the association between employment conditions and health (self-reported general health, mental health) among British adults with and without intellectual impairments at ages 30, 34 and 42. Our results indicated that: (1) British adults with intellectual impairments were more likely than their peers to be exposed to non-standard employment conditions and experience job insecurity; (2) in both groups exposure was typically associated with poorer health; (3) British adults with intellectual impairments in non-standard employment conditions were more likely than their peers to transition to economic inactivity; (4) among both groups, transitioning into employment was associated with positive health status and transitioning out of employment was associated with poorer health status...
April 2018: SSM—Population Health
Sean N Hatton, Matthew S Panizzon, Eero Vuoksimaa, Donald J Hagler, Christine Fennema-Notestine, Daniel Rinker, Lisa T Eyler, Carol E Franz, Michael J Lyons, Michael C Neale, Ming T Tsuang, Anders M Dale, William S Kremen
Two basic neuroimaging-based characterizations of white matter tracts are the magnitude of water diffusion along the principal tract orientation (axial diffusivity, AD) and water diffusion perpendicular to the principal orientation (radial diffusivity, RD). It is generally accepted that decreases in AD reflect disorganization, damage, or loss of axons, whereas increases in RD are indicative of disruptions to the myelin sheath. Previous reports have detailed the heritability of individual AD and RD measures, but have not examined the extent to which the same or different genetic or environmental factors influence these two phenotypes (except for corpus callosum)...
February 9, 2018: Human Brain Mapping
Ramesh S Krishnamurthy, Jason Hatton
No abstract text is available yet for this article.
January 1, 2018: Bulletin of the World Health Organization
Yue Wang, Hari Katepalli, Tonghan Gu, T Alan Hatton, Yundong Wang
Separation of Sm3+ from a dilute solution via conventional solvent extraction is often plagued by emulsion and third phase formation. These problems can be overcome with functionalized magnetic nanoparticles that can capture the target species and be separated from the raffinae phase rapidly and efficiently on application of a magnetic field. Magentic silica nanoparticles (Fe2O3/SiO2) were synthesized by a modified Stöber method and functionalized with carboxylate (Fe2O3/SiO2/RCOONa) and phosphonate (Fe2O3/SiO2/R1R2PO3Na) groups to achieve high adsorption capacity and fast adsorption kinetics...
February 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Gargi Roy, Tom Martin, Arnita Barnes, Jihong Wang, Rod Brian Jimenez, Megan Rice, Lina Li, Hui Feng, Shu Zhang, Raghothama Chaerkady, Herren Wu, Marcello Marelli, Diane Hatton, Jie Zhu, Michael A Bowen
The conserved glycosylation site Asn297 of a monoclonal antibody (mAb) can be decorated with a variety of sugars that can alter mAb pharmacokinetics and recruitment of effector proteins. Antibodies lacking the core fucose at Asn297 (afucosylated mAbs) show enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) and increased efficacy. Here, we describe the development of a robust platform for the manufacture of afucosylated therapeutic mAbs by engineering a Chinese hamster ovary (CHO) host cell line to co-express a mAb with GDP-6-deoxy-D-lyxo-4-hexulose reductase (RMD), a prokaryotic enzyme that deflects an intermediate in the de novo synthesis of fucose to a dead-end product, resulting in the production of afucosylated mAb (GlymaxX™ Technology, ProBioGen)...
February 5, 2018: MAbs
Natalie Wolkow, Frederick A Jakobiec, Mark P Hatton
Local corticosteroid injections are frequently employed by ophthalmologists to treat a variety of ocular, periocular, and orbital inflammatory conditions. Triamcinolone acetonide is a slowly dissolving crystalline corticosteroid that is often used for this purpose because of its prolonged anti-inflammatory effect. On occasion, previously injected corticosteroid material persists in tissues longer than anticipated, creating nodules that may masquerade as other disease conditions, or appearing incidentally in excised lesions on histopathologic examination...
January 17, 2018: Ophthalmic Plastic and Reconstructive Surgery
Cameron A Stewart, Yoav Finer, Benjamin D Hatton
Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control...
January 17, 2018: Scientific Reports
D Monks, A Neill, D Barton, A Moughty, A McFeely, A Timmons, S Hatton, D McMorrow
D-Dimer (DD) will increase with age and recent studies have shown the upper limit of normal can be raised in those who are low risk and over 50. We studied age adjusted D-dimer (AADD) levels to assess whether pulmonary embolism (PE) could be safely excluded. This study analysed the Emergency Department (ED) Computed Tomographic Pulmonary Angiography (CTPA) requests. There were 756 requests. The parameters studied were; age, DD value, calculated AADD, CT result and Simplified Geneva Score (SGS). The primary outcome was the diagnostic performance of AADD...
August 8, 2017: Irish Medical Journal
P Sanganalmath, J E Lester, A G Bradshaw, T Das, C Esler, A E F Roy, E Toy, J F Lester, M Button, P Wilson, C Comins, P Atherton, R Pickles, K Foweraker, G A Walker, M Keni, M Q Hatton
AIM: Continuous hyperfractionated accelerated radiotherapy (CHART) remains an option to treat non-small cell lung cancer (NSCLC; NICE, 2011). We have previously published treatment outcomes from 1998-2003 across five UK centres. Here we update the UK CHART experience, reporting outcomes and toxicities for patients treated between 2003 and 2009. MATERIALS AND METHODS: UK CHART centres were invited to participate in a retrospective data analysis of NSCLC patients treated with CHART from 2003 to 2009...
January 11, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
Fan He, P M Biesheuvel, Martin Z Bazant, T Alan Hatton
Capacitive deionization (CDI) for water treatment, which relies on the capture of charged species to sustain the electrical double layers (EDLs) established within porous electrodes under an applied electrical potential, can be enhanced by the chemical attachment of fixed charged groups to the porous electrode electrodes (ECDI). It has recently been demonstrated that further improvements in capacity and energy storage can be gained by functionalization of the electrode surfaces with redox polymers in which the charge on the electrodes can be modulated through Faradaic reactions under different cell voltages in a capacitive process that can be called "Faradaic CDI" (FaCDI)...
January 3, 2018: Water Research
Timothy J Hatton, Robert Sparrow, Daniel Suryadarma, Pierre van der Eng
We analyse the heights of children aged 2 to 12 in the Indonesian Family Life Survey (IFLS) focusing on the effect of the number of children in the family. Previous studies of the trade-off between the quantity of children and some measure of their quality have been much concerned with the endogeneity of fertility choices. Here we use the IFLS for 1993, 1997 and 2000 to exploit some unique institutional features that have influenced fertility. We find evidence that family size is influenced both from the supply side, as represented by components of the Indonesian family planning programme, and on the demand side, as represented by exposure to modern media...
December 13, 2017: Economics and Human Biology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"