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https://www.readbyqxmd.com/read/29778738/risk-adapted-therapy-for-young-children-with-medulloblastoma-sjyc07-therapeutic-and-molecular-outcomes-from-a-multicentre-phase-2-trial
#1
Giles W Robinson, Vasilisa A Rudneva, Ivo Buchhalter, Catherine A Billups, Sebastian M Waszak, Kyle S Smith, Daniel C Bowers, Anne Bendel, Paul G Fisher, Sonia Partap, John R Crawford, Tim Hassall, Daniel J Indelicato, Frederick Boop, Paul Klimo, Noah D Sabin, Zoltan Patay, Thomas E Merchant, Clinton F Stewart, Brent A Orr, Jan O Korbel, David T W Jones, Tanvi Sharma, Peter Lichter, Marcel Kool, Andrey Korshunov, Stefan M Pfister, Richard J Gilbertson, Robert P Sanders, Arzu Onar-Thomas, David W Ellison, Amar Gajjar, Paul A Northcott
BACKGROUND: Young children with medulloblastoma have a poor overall survival compared with older children, due to use of radiation-sparing therapy in young children. Radiotherapy is omitted or reduced in these young patients to spare them from debilitating long-term side-effects. We aimed to estimate event-free survival and define the molecular characteristics associated with progression-free survival in young patients with medulloblastoma using a risk-stratified treatment strategy designed to defer, reduce, or delay radiation exposure...
May 16, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29770223/profound-hearing-loss-following-surgery-in-pediatric-patients-with-posterior-fossa-low-grade-glioma
#2
Yahya Ghazwani, Ibrahim Qaddoumi, Johnnie K Bass, Shengjie Wu, Jason Chiang, Frederick Boop, Amar Gajjar, Zsila Sadighi
Background: Hearing loss may occur in patients with posterior fossa low-grade glioma who undergo surgery. Methods: We retrospectively reviewed 217 patients with posterior fossa low-grade glioma, including 115 for whom results of hearing tests performed after surgery and before chemotherapy or radiation therapy were available. We explored the association of UHL with age at diagnosis, sex, race, tumor location, extent of resection, posterior fossa syndrome, ventriculoperitoneal shunt placement, and histology...
May 2018: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29712533/introduction-neurosurgical-economics-and-cost-effectiveness
#3
Meic H Schmidt, Frederick A Boop, Neil A Martin, Jonathan R Slotkin
No abstract text is available yet for this article.
May 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29701548/global-neurosurgery-the-current-capacity-and-deficit-in-the-provision-of-essential-neurosurgical-care-executive-summary-of-the-global-neurosurgery-initiative-at-the-program-in-global-surgery-and-social-change
#4
Michael C Dewan, Abbas Rattani, Graham Fieggen, Miguel A Arraez, Franco Servadei, Frederick A Boop, Walter D Johnson, Benjamin C Warf, Kee B Park
OBJECTIVE Worldwide disparities in the provision of surgical care result in otherwise preventable disability and death. There is a growing need to quantify the global burden of neurosurgical disease specifically, and the workforce necessary to meet this demand. METHODS Results from a multinational collaborative effort to describe the global neurosurgical burden were aggregated and summarized. First, country registries, third-party modeled data, and meta-analyzed published data were combined to generate incidence and volume figures for 10 common neurosurgical conditions...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29660028/reoperation-for-medulloblastoma-prior-to-adjuvant-therapy
#5
Prayash Patel, David Wallace, Frederick A Boop, Brandy Vaughn, Giles W Robinson, Amar Gajjar, Paul Klimo
BACKGROUND: Surgery remains an integral part of the treatment of medulloblastoma. We present our experience with repeat surgery for this tumor before initiation of adjuvant therapy. OBJECTIVE: To report what was found intraoperatively and where at time of second-look surgery and detail any postoperative events or readmissions within 90 days of surgery. METHODS: Two separate institutional databases were queried to identify patients who underwent repeat resection of suspected residual medulloblastoma from January 2003 to January 2017...
April 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29600910/retrospective-single-surgeon-study-of-1123-consecutive-cases-of-anterior-cervical-discectomy-and-fusion-a-comparison-of-clinical-outcome-parameters-complication-rates-and-costs-between-outpatient-and-inpatient-surgery-groups-with-a-literature-review
#6
Jack Mullins, Mirza Pojskić, Frederick A Boop, Kenan I Arnautović
OBJECTIVE Outpatient anterior cervical discectomy and fusion (ACDF) is becoming more common and has been reported to offer advantages over inpatient procedures, including reducing nosocomial infections and costs, as well as improving patient satisfaction. The goal of this retrospective study was to evaluate and compare outcome parameters, complication rates, and costs between inpatient and outpatient ACDF cases performed by 1 surgeon at a single institution. METHODS In a retrospective study, the records of all patients who had undergone first-time ACDF performed by a single surgeon in the period from June 1, 2003, to January 31, 2016, were reviewed...
March 30, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29488422/species-composition-of-the-genus-scombrops-teleostei-scombropidae-in-the-waters-around-the-japanese-archipelago-detection-of-a-cryptic-species
#7
Shiro Itoi, Yukako Mochizuki, Minori Tanaka, Hikaru Oyama, Tadasuke Tsunashima, Riko Yamada, Hirotoshi Shishido, Yasuji Masuda, Shizuko Nakai, Noriyuki Takai, Hideto Fukushima, Koko Abe, Takahito Kojima, Haruo Sugita
Current literature states that family Scombropidae consists of a single genus Scombrops comprising three species worldwide, with two of them, Scombrops boops and Scombrops gilberti, distributed in the waters around the Japanese Archipelago. Although these two scombropids are commercially important species, little is known about the ecology of these fishes. It is difficult to discriminate between these two species based on external characteristics because of their morphological similarity. Here, we report two different morphotypes characterized by the relative growth between the otolith size and the standard length (SL) of the scombropid specimens caught in southern waters off Kyushu Island, Japan, and show the genetic relationship between the morphotypes by means of phylogenetic analyses using complete DNA sequences of the cytochrome b gene...
February 28, 2018: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29414401/predicting-postoperative-language-outcome-using-presurgical-fmri-meg-tms-and-high-gamma-ecog
#8
Abbas Babajani-Feremi, Christen M Holder, Shalini Narayana, Stephen P Fulton, Asim F Choudhri, Frederick A Boop, James W Wheless
OBJECTIVE: To predict the postoperative language outcome using the support vector regression (SVR) and results of multimodal presurgical language mapping. METHODS: Eleven patients with epilepsy received presurgical language mapping using functional MRI (fMRI), magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), and high-gamma electrocorticography (hgECoG), as well as pre- and postoperative neuropsychological evaluation of language. We constructed 15 (24 -1) SVR models by considering the extent of resected language areas identified by all subsets of four modalities as input feature vector and the postoperative language outcome as output...
March 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29348882/microrna203a-suppresses-glioma-tumorigenesis-through-an-atm-dependent-interferon-response-pathway
#9
Chuan He Yang, Yinan Wang, Michelle Sims, Chun Cai, Ping He, Hans Häcker, Junming Yue, Jinjun Cheng, Frederick A Boop, Lawrence M Pfeffer
Glioblastoma (GBM) is a deadly and incurable brain tumor. Although microRNAs (miRNAs) play critical roles in regulating the cancer cell phenotype, the underlying mechanisms of how they regulate tumorigenesis are incompletely understood. We previously showed that miR-203a is expressed at relatively low levels in GBM patients, and ectopic miR-203a expression in GBM cell lines inhibited cell proliferation and migration, increased sensitivity to apoptosis induced by interferon (IFN) or temozolomide in vitro , and inhibited GBM tumorigenesis in vivo ...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29307727/limited-possibilities-for-prezygotic-barriers-in-the-reproductive-behaviour-of-sympatric-ophthalmotilapia-species-teleostei-cichlidae
#10
Loïc Kéver, Eric Parmentier, Sofie Derycke, Erik Verheyen, Jos Snoeks, Maarten Van Steenberge, Pascal Poncin
Since prezygotic rather than postzygotic barriers are believed to maintain the diversity of closely related sympatric cichlids, differences in phenotypic traits and reproductive behaviours are likely involved in maintaining species boundaries. Here, we focused on the reproductive behaviour of three Ophthalmotilapia species with distributions that only overlap on a small stretch of the shore line of Lake Tanganyika. Repeated introgression of mitochondrial DNA between these species was previously reported, which suggested they can hybridise...
February 2018: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/29229339/hemangioblastomas-of-the-posterior-cranial-fossa-in-adults-demographics-clinical-morphologic-pathologic-surgical-features-and-outcomes-a-systematic-review
#11
Marin Kuharic, Dragan Jankovic, Bruno Splavski, Frederick A Boop, Kenan I Arnautovic
BACKGROUND: Posterior cranial fossa (PCF) hemangioblastomas are benign, highly vascularized, and well-differentiated tumors with well-described histopathologic features. Although relatively rare, this tumor is the most prevalent primary tumor of the cerebellum in adults. OBJECTIVE: Because the demographics of patients with such a tumor (as well as the clinical, morphologic, pathologic, surgical features, and outcomes) are not fully understood, we systematized characteristic patient and tumor features...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29229328/outcomes-after-reirradiation-for-recurrent-pediatric-intracranial-ependymoma
#12
Derek S Tsang, Elizabeth Burghen, Paul Klimo, Frederick A Boop, David W Ellison, Thomas E Merchant
PURPOSE: To determine the long-term outcomes and the optimal dose and volume for reirradiation of recurrent pediatric ependymoma. METHODS AND MATERIALS: Patients with recurrent ependymoma treated with a second course of fractionated radiation therapy (RT2) were reviewed retrospectively. Eligible patients had localized, intracranial ependymoma at initial diagnosis that was treated with focal radiation (RT1) without craniospinal irradiation (CSI) and were aged ≤21 years at the time of RT2...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29191125/the-2017-aans-presidential-address-a-world-of-innovation
#13
Frederick A Boop
The 2016 scientific meeting of the American Association of Neurological Surgeons (AANS) focused on the theme "A World of Innovation." In his presidential address, 2016 AANS President Frederick Boop compared the historical development of the specialty of neurological surgery with that of the development of global communications. In the early years, general surgeons training in the United States would spend post-residency time abroad learning from surgical masters in Europe and other places. Since Harvey Cushing's day, neurosurgeons from around the world continue to travel abroad, with many now coming to America for training at centers of excellence...
December 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29187787/ancient-diversity-of-afrotropical-microborus-three-endemic-species-not-one-widespread
#14
Bjarte H Jordal
The primarily Neotropical genus Microborus Blandford is represented with three species in Africa and Madagascar. The previously recorded species from this region, M. boops Blandford, is a Neotropical species restricted to Central America and is likely not found in the Afrotropics. The previously recognised species in western parts of Africa is M. camerunus (Eggers) and is resurrected from synonymy under M. boops. Molecular and morphological data revealed a second species of this complex in Madagascar, M. brevisetosus Jordal...
2017: ZooKeys
https://www.readbyqxmd.com/read/29021352/successful-motor-mapping-with-transcranial-magnetic-stimulation-in-an-infant-a-case-report
#15
Shalini Narayana, Basanagoud Mudigoudar, Abbas Babajani-Feremi, Asim F Choudhri, Frederick A Boop
No abstract text is available yet for this article.
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/28986227/anterior-cervical-discectomy-with-instrumented-allograft-fusion-lordosis-restoration-and-comparison-of-functional-outcomes-among-patients-of-different-age-groups
#16
COMPARATIVE STUDY
Dario Muzević, Bruno Splavski, Frederick A Boop, Kenan I Arnautović
OBJECTIVE: To investigate clinical parameters of anterior cervical discectomy and fusion (ACDF) treatment and outcomes using osseous allografts in different age groups, study the postoperative results of restoration of lordosis, and evaluate the utility of bone allografts for ACDF, including graft subsidence. METHODS: We reviewed data from 154 patients with clinical symptoms and radiologic signs of disc herniation and/or cervical spondylosis. Decompression was achieved through discectomy, osteophyte ablation, endplate drilling, and foraminotomy...
January 2018: World Neurosurgery
https://www.readbyqxmd.com/read/28931256/the-posterior-transcallosal-approach-to-the-pineal-region-and-posterior-third-ventricle-intervenous-and-paravenous-variants
#17
Prayash G Patel, Aaron A Cohen-Gadol, Philippe Mercier, Frederick A Boop, Paul Klimo
BACKGROUND: There are a number of surgical approaches to the posterior third ventricle and pineal region, each with its associated advantages and disadvantages. OBJECTIVE: To present our experience with the posterior interhemispheric transcallosal approach and to analyze the indications, technique, and outcomes. METHODS: A retrospective study was conducted to identify and analyze all children and young adults who underwent the posterior transcallosal approach from July 2010 to March 2015...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28763944/determination-of-steroid-hormones-in-fish-tissues-by-microwave-assisted-extraction-coupled-to-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#18
Rayco Guedes-Alonso, Zoraida Sosa-Ferrera, José Juan Santana-Rodríguez
Steroid hormones produce adverse effects on biota as well as bioaccumulation in fish and seafood, making it necessary to develop methodologies to evaluate these compounds in samples related to the food chain. This work presents an analytical method for evaluating 15 steroid hormones in fish tissue. It is based on microwave-assisted extraction and solid-phase extraction coupled to ultra-high-performance liquid chromatography tandem mass spectrometry (MAE-SPE-UHPLC-MS/MS). The proposed method shows appropriate detection limits (0...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28728846/the-effects-of-type-i-interferon-on-glioblastoma-cancer-stem-cells
#19
Ziyun Du, Chun Cai, Michelle Sims, Frederick A Boop, Andrew M Davidoff, Lawrence M Pfeffer
Glioblastomas (GBMs) are highly invasive brain tumors that are extremely deadly. The highly aggressive nature of GBM as well as its heterogeneity at the molecular and cellular levels has been attributed to a rare subpopulation of GBM stem-like cells (GSCs). Interferons (IFNs) are a family of endogenous antiviral proteins that have anticancer activity in vitro, and have been used clinically to treat GBM. IFN inhibits the proliferation of various established GBM cell lines, but the effects of IFNs on GSCs remain relatively unknown...
September 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28716297/on-the-relative-merits-of-invasive-and-non-invasive-pre-surgical-brain-mapping-new-tools-in-ablative-epilepsy-surgery
#20
Andrew C Papanicolaou, Roozbeh Rezaie, Shalini Narayana, Asim F Choudhri, Abbas-Babajani-Feremi, Frederick A Boop, James W Wheless
Cortical Stimulation Mapping (CSM) and the Wada procedure have long been considered the gold standard for localizing motor and language-related cortical areas and for determining the language and memory-dominant hemisphere, respectively. In recent years, however, non-invasive methods such as magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), and transcranial magnetic stimulation (TMS) have emerged as promising alternatives to the aforementioned procedures, particularly in cases where the invasive localization of eloquent cortex has proven to be challenging...
July 3, 2017: Epilepsy Research
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