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https://www.readbyqxmd.com/read/28806185/graft-quality-verification-in-coronary-artery-bypass-graft-surgery-how-when-and-why
#1
Teresa M Kieser
PURPOSE OF REVIEW: The coronary artery bypass graft (CABG) operation is one of the few remaining operations/interventions on diseased arteries that are not routinely verified during or immediately after the procedure. This review answers the 'how', 'when' and 'why' of intraoperative CABG assessment. RECENT FINDINGS: More recent than new literature on this topic, is the increased interest in quality assurance of CABG. This is most likely due to reports in the last 5 years suggesting CABG superiority to percutaneous coronary intervention (PCI) for improved mid-term and long-term outcomes; for example, for patients with diabetes mellitus (Freedom Trial by Farkouh in 2012), and for patients with SYNTAX score ≥ 33 (SYNTAX Trial by Mohr in 2013)...
August 12, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28803212/data-driven-classification-of-patients-with-primary-progressive-aphasia
#2
Paul Hoffman, Seyed Ahmad Sajjadi, Karalyn Patterson, Peter J Nestor
Current diagnostic criteria classify primary progressive aphasia into three variants-semantic (sv), nonfluent (nfv) and logopenic (lv) PPA-though the adequacy of this scheme is debated. This study took a data-driven approach, applying k-means clustering to data from 43 PPA patients. The algorithm grouped patients based on similarities in language, semantic and non-linguistic cognitive scores. The optimum solution consisted of three groups. One group, almost exclusively those diagnosed as svPPA, displayed a selective semantic impairment...
August 10, 2017: Brain and Language
https://www.readbyqxmd.com/read/28798996/operative-results-and-oncologic-outcomes-of-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-versus-two-stage-hepatectomy-tsh-in-patients-with-unresectable-colorectal-liver-metastases-a-systematic-review-and-meta-analysis
#3
REVIEW
Dimitrios Moris, Sean Ronnekleiv-Kelly, Ioannis D Kostakis, Diamantis I Tsilimigras, Eliza W Beal, Alexandros Papalampros, Dimitrios Dimitroulis, Evangelos Felekouras, Timothy M Pawlik
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has recently emerged as a treatment choice for patients with colorectal liver metastases (CLM) and inadequate future liver remnant (FLR). The aim of this study was to define the results of ALPPS compared with two-stage hepatectomy (TSH) for patients with CLM. MATERIALS AND METHODS: A meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analysis guidelines...
August 10, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28792963/unzipping-zipf-s-law
#4
Sander Lestrade
In spite of decades of theorizing, the origins of Zipf's law remain elusive. I propose that a Zipfian distribution straightforwardly follows from the interaction of syntax (word classes differing in class size) and semantics (words having to be sufficiently specific to be distinctive and sufficiently general to be reusable). These factors are independently motivated and well-established ingredients of a natural-language system. Using a computational model, it is shown that neither of these ingredients suffices to produce a Zipfian distribution on its own and that the results deviate from the Zipfian ideal only in the same way as natural language itself does...
2017: PloS One
https://www.readbyqxmd.com/read/28790953/functionally-equivalent-variants-in-a-non-standard-variety-and-their-implications-for-universal-grammar-a-spontaneous-speech-corpus
#5
Evelina Leivada, Elena Papadopoulou, Natalia Pavlou
Findings from the field of experimental linguistics have shown that a native speaker may judge a variant that is part of her grammar as unacceptable, but still use it productively in spontaneous speech. The process of eliciting acceptability judgments from speakers of non-standard languages is sometimes clouded by factors akin to prescriptive notions of grammatical correctness. It has been argued that standardization enhances the ability to make clear-cut judgments, while non-standardization may result to grammatical hybridity, often manifested in the form of functionally equivalent variants in the repertoire of a single speaker...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28789845/discrepancy-between-fractional-flow-reserve-and-instantaneous-wave-free-ratio-clinical-and-angiographic-characteristics
#6
Joo Myung Lee, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Doyeon Hwang, Jonghanne Park, Kyung-Jin Kim, Jinlong Zhang, Bon-Kwon Koo
BACKGROUND: The invasive physiologic index such as fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) is used in clinical practice to identify ischemia-causing stenosis and to guide treatment strategy. We investigated clinical and angiographic characteristics of lesions with discrepancy between FFR and iFR. METHODS: From the 3V FFR-FRIENDS study, 975 vessels (393 patients) with available pre-intervention FFR and iFR were included in this study...
August 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28789844/impact-of-coronary-artery-disease-in-patients-undergoing-transfemoral-transcatheter-aortic-valve-implantation
#7
Jasmin Shamekhi, Anja Stundl, Marcel Weber, Fritz Mellert, Armin Welz, Eberhard Grube, Georg Nickenig, Nikos Werner, Jan-Malte Sinning
BACKGROUND: The impact of coronary artery disease (CAD) and revascularization on outcome in patients undergoing transcatheter aortic valve implantation (TAVI) has not been fully elucidated so far. OBJECTIVES: To assess whether the degree of CAD influences the prognosis of patients undergoing TAVI. METHODS: Before TAVI, all patients underwent revascularization of the proximal vessels or the left main stem if indicated (stenosis ≥70% or 50%, respectively)...
July 25, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28780509/rehospitalizations-following-primary-percutaneous-coronary-intervention-in-patients-with-st-elevation-myocardial-infarction-results-from-a-multi-center-randomized-trial
#8
Ernest Spitzer, Martina Frei, Serge Zaugg, Susanne Hadorn, Henning Kelbaek, Miodrag Ostojic, Andreas Baumbach, David Tüller, Marco Roffi, Thomas Engstrom, Giovanni Pedrazzini, Vladan Vukcevic, Michael Magro, Ran Kornowski, Thomas F Lüscher, Clemens von Birgelen, Dik Heg, Stephan Windecker, Lorenz Räber
BACKGROUND: Rehospitalizations (RHs) after ST-elevation myocardial infarction carry a high economic burden and may deteriorate quality of life. Characterizing patients at higher risk may allow the design of preventive measures. We studied the frequency, reasons, and predictors for unplanned cardiac and noncardiac RHs in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. METHODS AND RESULTS: In this post-hoc analysis of the COMFORTABLE AMI (Comparison of Biolimus Eluted From an Erodible Stent Coating With Bare Metal Stents in Acute ST-Elevation Myocardial Infarction; NCT00962416) trial including 1137 patients, unplanned cardiac and noncardiac RHs occurred in 133 (11...
August 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28780312/losing-ground-frontostriatal-atrophy-disrupts-language-embodiment-in-parkinson-s-and-huntington-s-disease
#9
REVIEW
Agustina Birba, Indira García-Cordero, Giselle Kozono, Agustina Legaz, Agustín Ibáñez, Lucas Sedeño, Adolfo M García
Within the language domain, movement disorders triggered by frontostriatal damage are characterized by deficits in action verbs, motor-language coupling, and syntax. However, these impairments have not been jointly interpreted under a unifying rationale or integratively assessed in terms of possible clinical implications. To bridge these gaps, here we introduce the "disrupted motor grounding hypothesis", a new framework to conceive such impairments as disturbances of embodied mechanisms (high-order domains based on the recycling of functionally germane sensorimotor circuits)...
August 2, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28779872/embodied-cognition-and-the-cerebellum-perspectives-from-the-dysmetria-of-thought-and-the-universal-cerebellar-transform-theories
#10
Xavier Guell, John D E Gabrieli, Jeremy D Schmahmann
In this report, we analyze the relationship between embodied cognition and current theories of the cerebellum, particularly the Dysmetria of Thought theory and the concept of the Universal Cerebellar Transform (UCT). First, we describe the UCT and the Dysmetria of Thought theories, highlight evidence supporting these hypotheses and discuss their mechanisms, functions and relevance. We then propose the following relationships. (i) The UCT strengthens embodied cognition because it provides an example of embodiment where the nature and intensity of the dependence between cognitive, affective and sensorimotor processes are defined...
July 14, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28774187/mean-platelet-volume-to-lymphocyte-ratio-as-a-novel-marker-for-severity-and-complexity-of-coronary-atherosclerosis-in-patients-with-acute-coronary-syndrome
#11
Alparslan Kilic, Alparslan Kurtul
The thromboinflammatory process plays an important role in the pathophysiology of acute coronary syndrome (ACS). Recently, the mean platelet volume-to-lymphocyte ratio (MPVLR) has been suggested as a prognostic marker in patients with ACS. We assessed the association of MPVLR with the severity and complexity of coronary atherosclerosis in patients with ACS. A total of 1782 patients undergoing urgent coronary angiography were enrolled. The SYNTAX score (SXscore) was calculated for each patient. Patients were divided into 2 groups: low SXscore (<23) and intermediate-to-high SXscore (≥23)...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28772245/the-relationship-between-executive-functioning-and-language-examining-vocabulary-syntax-and-language-learning-in-preschoolers-attending-head-start
#12
Lisa J White, Alexandra Alexander, Daryl B Greenfield
Early childhood marks a time of dynamic development within language and cognitive domains. Specifically, a body of research focuses on the development of language as related to executive functions, which are foundational cognitive skills that relate to both academic achievement and social-emotional development during early childhood and beyond. Although there is evidence to support the relationship between language and executive functions, existing studies focus mostly on vocabulary and fail to examine other components of language such as syntax and language learning skills...
July 31, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28771550/gdf-15-predicts-cardiovascular-events-in-acute-chest-pain-patients
#13
Stergios Tzikas, Lars Palapies, Constantinos Bakogiannis, Tanja Zeller, Christoph Sinning, Stephan Baldus, Christoph Bickel, Vassilios Vassilikos, Karl J Lackner, Andreas Zeiher, Thomas Münzel, Stefan Blankenberg, Till Keller
BACKGROUND: Treatment of patients presenting with possible acute myocardial infarction (AMI) is based on timely diagnosis and proper risk stratification aided by biomarkers. We aimed at evaluating the predictive value of GDF-15 in patients presenting with symptoms suggestive of AMI. METHODS: Consecutive patients presenting with suspected AMI were enrolled in three study centers. Cardiovascular events were assessed during a follow-up period of 6 months with a combined endpoint of death or MI...
2017: PloS One
https://www.readbyqxmd.com/read/28770620/oxidative-stress-and-syntax-score-in-patients-with-stable-coronary-artery-disease
#14
Selami Soylemez
Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016).
August 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28770617/oxidative-stress-biomarkers-and-burden-of-coronary-atherosclerosis-assessed-based-on-syntax-score
#15
Mehmet Kadri Akboga, Samet Yilmaz
Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 10(4), 375-383 (2016). In response to: Soylemez S.Oxidative stress and SYNTAX score in patients with stable coronary artery disease. Biomark. Med. 11(8), doi:10.2217/bmm-2016-0326 (2017) (Epub ahead of print).
August 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28769020/activation-changes-of-the-left-inferior-frontal-gyrus-for-the-factors-of-construction-and-scrambling-in-a-sentence
#16
Kyohei Tanaka, Shinri Ohta, Ryuta Kinno, Kuniyoshi L Sakai
Our previous functional magnetic resonance imaging (fMRI) studies have indicated that the left dorsal inferior frontal gyrus (L. dF3op/F3t) and left lateral premotor cortex (L. LPMC) are crucial regions for syntactic processing among the syntax-related networks. In the present study, we further examined how activations in these regions were modified by the factors of construction and scrambling (object-initial type). Using various sentence types, we clarified three major points. First, we found that the main effects of construction and scrambling consistently activated the L...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/28760723/impact-of-residual-syntax-score-on-clinical-outcomes-after-incomplete-revascularization-percutaneous-coronary-intervention-a-large-single-centre-study
#17
Ying Song, Zhan Gao, Xiaofang Tang, Ping Jiang, Jingjing Xu, Yi Yao, Jianxin Li, Xueyan Zhao, Shubin Qiao, Yuejin Yang, Runlin Gao, Bo Xu, Jinqing Yuan
AIMS: This study assessed the prognostic capacity of residual SYNTAX score (rSS) in a large cohort of patients undergoing percutaneous coronary intervention(PCI) in clinical practice. METHODS AND RESULTS: 10,344 consecutive patients were prospectively enrolled. Complete revascularization (CR; rSS=0), reasonable incomplete revascularization (RICR; 0 < rSS ≤ 8), and ICR (rSS > 8) were achieved in 5375 (51.9%), 3401 (32.9%), and 1568 (15.2%) patients. During 2-year follow-up, ICR patients had the highest incidences of major adverse cardiovascular and cerebrovascular events (MACCE; 20...
August 1, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28760214/clinical-outcomes-with-percutaneous-coronary-revascularization-vs-coronary-artery-bypass-grafting-surgery-in-patients-with-unprotected-left-main-coronary-artery-disease-a-meta-analysis-of-6-randomized-trials-and-4-686-patients
#18
Tullio Palmerini, Patrick Serruys, Arie Pieter Kappetein, Philippe Genereux, Diego Della Riva, Letizia Bacchi Reggiani, Evald Christiansen, Niels R Holm, Leif Thuesen, Timo Makikallio, Marie Claude Morice, Jung-Min Ahn, Seung-Jung Park, Holger Thiele, Enno Boudriot, Mario Sabatino, Mattia Romanello, Giuseppe Biondi-Zoccai, Raphael Cavalcante, Joseph F Sabik, Gregg W Stone
Some but not all randomized controlled trials (RCT) have suggested that percutaneous coronary intervention (PCI) with drug-eluting stents may be an acceptable alternative to coronary artery bypass grafting (CABG) surgery for the treatment of unprotected left main coronary artery disease (ULMCAD). We therefore aimed to compare the risk of all-cause mortality between PCI and CABG in patients with ULMCAD in a pairwise meta-analysis of RCT. METHODS: Randomized controlled trials comparing PCI vs CABG for the treatment of ULMCAD were searched through MEDLINE, EMBASE, Cochrane databases, and proceedings of international meetings...
August 2017: American Heart Journal
https://www.readbyqxmd.com/read/28752728/evaluation-of-on-clopidogrel-platelet-reactivity-overtime-syntax-score-genetic-polymorphisms-and-their-relationship-to-one-year-clinical-outcomes-in-stemi-patients-undergoing-pci
#19
Harsha V Erathi, Rajasekhar Durgaprasad, Vanajakshamma Velam, P V Sarma, Madhavi Rodda, C Kapil, Sreedhar N Kanavath
OBJECTIVES: To investigate the variability of On-clopidogrel platelet reactivity overtime, the association between HTPR, gene polymorphism and Syntax Score (SS) for risk prediction of MACE in patients with ST-Elevation Myocardial Infarction (STEMI) undergoing percutaneous coronary intervention (PCI). BACKGROUND: Platelet function testing may be used to optimize antiplatelet therapy in high risk patients, but identification of this subset of patients remains a challenge...
July 27, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28750824/syntax-score-and-pre-and-poststent-optical-coherence-tomography-findings-in-the-left-anterior-descending-coronary-artery-in-patients-with-stable-angina-pectoris
#20
Krzysztof L Bryniarski, Darren L Walters, Chong-Jin Kim, Tsunenari Soeda, Takumi Higuma, Erika Yamamoto, Lei Xing, Tomoyo Sugiyama, Thomas Zanchin, Leszek Bryniarski, Dariusz Dudek, Hang Lee, Ik-Kyung Jang
SYNTAX score (SS) has been reported to be an independent predictor of future cardiac events including target lesion revascularization. The aim of this study was to assess the relation between SS and plaque characteristics and poststent vascular response using optical coherence tomography in coronary artery tree and left anterior descending artery (LAD) in patients with stable angina. A total of 179 lesions among 165 patients, including 100 lesions in LAD, were analyzed. Patients were stratified into tertiles...
June 28, 2017: American Journal of Cardiology
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