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https://www.readbyqxmd.com/read/29142046/quantitative-analysis-of-interferon-%C3%AE-release-assay-response-in-children-with-latent-and-active-tuberculosis
#1
Giulia Lombardi, Roberta Petrucci, Ilaria Corsini, Maria Letizia Bacchi Reggiani, Francesca Visciotti, Filippo Bernardi, Maria Paola Landini, Salvatore Cazzato, Paola Dal Monte
The use of interferon-γ (IFN-γ) release assays (IGRAs) for the diagnosis of tuberculosis (TB) infection in children is still under debate because of concerns about their immature immune response.The aim of this study was to investigate quantitative values of QuantiFERON®-TB Gold In-Tube (QFT-IT), a commercially available IGRA, in a large cohort of children screened for TB infection.A retrospective analysis was conducted on samples from 517 children aged 0-14 years old at the Pediatric Unit of S. Orsola-Malpighi University Hospital of Bologna (Italy); quantitative responses to QFT-IT stimuli were analyzed according to diagnosis and age...
November 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29140933/t-spot-tb%C3%A2-performance-in-routine-pediatric-practice-in-a-low-tb-burden-setting
#2
Anna M Mandalakas, Heather Y Highsmith, Nadine M Harris, Anna Pawlicka, H Lester Kirchner
BACKGROUND: The T-SPOT.TB, an interferon-γ release assay (IGRA), is an indirect test of Mycobacterium tuberculosis infection. Due to sparse and conflicting evidence, IGRA use is limited in young and HIV-infected children. We determined the prevalence of invalid, borderline, positive, and negative results and associations with key demographic variables during routine pediatric use in a TB low-burden setting. METHODS: For pediatric samples received at Oxford Diagnostic Laboratories from 2010-2015, the associations between initial test outcome and demographics were estimated by bivariate analysis and logistic regression...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29125874/pulmonary-immune-responses-to-mycobacterium-tuberculosis-in-exposed-individuals
#3
Christian Herzmann, Martin Ernst, Christoph Lange, Steffen Stenger, Stefan H E Kaufmann, Norbert Reiling, Tom Schaberg, Lize van der Merwe, Jeroen Maertzdorf
BACKGROUND: Blood based Interferon-(IFN)-γ release assays (IGRAs) have a poor predictive value for the development of tuberculosis. This study aimed to investigate the correlation between IGRAs and pulmonary immune responses in tuberculosis contacts in Germany. METHODS: IGRAs were performed on bronchoalveolar lavage (BAL) cells and peripheral blood from close healthy contacts of patients with culturally confirmed tuberculosis. Cellular BAL composition was determined by flow cytometry...
2017: PloS One
https://www.readbyqxmd.com/read/29108749/sensitivity-and-specificity-of-quantiferon-tb-gold-plus-compared-with-quantiferon-tb-gold-in-tube-and-t-spot-tb-on-active-tuberculosis-in-japan
#4
Jin Takasaki, Toshie Manabe, Eriko Morino, Yoshikazu Muto, Masao Hashimoto, Motoyasu Iikura, Shinyu Izumi, Haruhito Sugiyama, Koichiro Kudo
BACKGROUND: The QuantiFERON-TB Gold Plus (QFT-Plus) was introduced in 2015 as a new generation of interferon-gamma release assays (IGRAs) designed to detect Mycobacterium tuberculosis infection (TB). Examination of its diagnostic accuracy is crucial before it is launched in Japan. METHOD: We examined 99 patients with laboratory-confirmed active TB (patients) and 117 healthy volunteers with no risk of TB infection (controls) at a medical center in Tokyo, Japan. Blood samples were collected from both the patients and controls and tested using three types of IGRAs: the QFT-Plus, the QuantiFERON-TB Gold In-Tube (QFT-GIT), and the T-SPOT...
November 3, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29076252/tuberculosis-screening-prior-to-anti-tumor-necrosis-factor-therapy-among-patients-with-immune-mediated-inflammatory-diseases-in-japan-a-longitudinal-study-using-a-large-scale-health-insurance-claims-database
#5
Jun Tomio, Hayato Yamana, Hiroki Matsui, Hiroyuki Yamashita, Takashi Yoshiyama, Hideo Yasunaga
AIM: Tuberculosis screening is recommended for patients with immune-mediated inflammatory diseases (IMIDs) prior to anti-tumor necrosis factor (TNF) therapy. However, adherence to the recommended practice is unknown in the current clinical setting in Japan. METHODS: We used a large-scale health insurance claims database in Japan to conduct a longitudinal observational study. Of more than two million beneficiaries in the database between 2013 and 2014, we enrolled those with IMIDs aged 15-69 years who had initiated anti-TNF therapy...
October 26, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29075255/il-17-production-from-t-helper-17-mucosal-associated-invariant-t-and-%C3%AE-%C3%AE-cells-in-tuberculosis-infection-and-disease
#6
Felicity Coulter, Amy Parrish, Declan Manning, Beate Kampmann, Joseph Mendy, Mathieu Garand, David M Lewinsohn, Eleanor M Riley, Jayne S Sutherland
IL-17-producing cells have been shown to be important in the early stages of Mycobacterium tuberculosis (Mtb) infection in animal models. However, there are very little data on the role of IL-17 in human studies of tuberculosis (TB). We recruited TB patients and their highly exposed contacts who were further categorized based on results from an IFN-γ-release assay (IGRA): (1) IGRA positive (IGRA(+)) at recruitment (latently TB infected), (2) IGRA negative (IGRA(-)) at recruitment and 6 months [non-converters (NC)], and (3) IGRA(-) at recruitment and IGRA(+) at 6 months (converters)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29054459/lymphocyte-subset-analysis-in-quantiferon-tb-gold-plus-and-t-spot-tb-for-latent-tuberculosis-infection-in-rheumatoid-arthritis
#7
Hidetoshi Igari, Satoru Ishikawa, Takuya Nakazawa, Yoshihiro Oya, Hidekazu Futami, Mizue Tsuyuzaki, Kiminori Suzuki, Ryutaro Matsumura
Rheumatoid arthritis (RA) is an immune mediated inflammatory disorder, and immune suppressive drugs are prescribed. RA patients receiving treatments are in a kind of immunosuppressive condition that presents increased risk of developing active tuberculosis. Accurate diagnosis of latent tuberculosis infection (LTBI) is recommended for RA. QuantiFERON(®)-TB Gold Plus (QFT-Plus), a novel IGRA, has two tubes (TB1 and TB2). TB2 is designed to elicit both CD4 and CD8 T-cell responses, with expected increased sensitivity...
October 18, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29051973/igra-testing-in-patients-with-immune-mediated-inflammatory-diseases-which-factors-influence-the-results
#8
Juan González-Moreno, Mercedes García-Gasalla, Inés Losada-López, Carmen Cifuentes Luna, Isabel Mir Viladrich, Victoria Fernández-Baca, Araceli Serrano, Antonio Juan Mas, Joan Riera-Oliver, Antoni Payeras Cifre
Diagnosis of latent tuberculosis infection in patients with immune-mediated inflammatory chronic diseases (IMIDs) can be challenged as diagnostic test reliability could be impaired by immunosuppression. We retrospectively analyzed the Quantiferon Gold-Test in-Tube (QFT-G-IT) results of all patients with IMIDs seen at the Department of Internal Medicine of Son Llàtzer Hospital, Palma de Mallorca (Spain), looking for the factors related to QFT-G-IT indeterminate results. During the study period (2008-2015), 520 patients met the inclusion criteria...
October 19, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29050777/multiplex-analysis-of-plasma-cytokines-chemokines-showing-different-immune-responses-in-active-tb-patients-latent-tb-infection-and-healthy-participants
#9
Xiangyang Yao, Yongliang Liu, Yang Liu, Wei Liu, Zhizhong Ye, Chao Zheng, Shengxiang Ge
Interferon gamma release assays (IGRAs) have been widely used to diagnose Mycobacterium tuberculosis (MTB) infection. However, IGRAs cannot discriminate between active TB patients and latent TB infection (LTBI), and the sensitivity of IGRAs for MTB infection is suboptimal. Here, we analyzed cytokines/chemokines in MTB antigen-stimulated and -unstimulated plasma samples to identify host biomarkers that are associated with active TB and MTB infection. Active TB patients, subjects with LTBI and healthy participants were recruited...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29049814/cost-effectiveness-of-testing-and-treatment-for-latent-tuberculosis-infection-in-residents-born-outside-the-united-states-with-and-without-medical-comorbidities-in-a-simulation-model
#10
Abriana Tasillo, Joshua A Salomon, Thomas A Trikalinos, C Robert Horsburgh, Suzanne M Marks, Benjamin P Linas
Importance: Testing for and treating latent tuberculosis infection (LTBI) is among the main strategies to achieve TB elimination in the United States. The best approach to testing among non-US born residents, particularly those with comorbid conditions, is uncertain. Objective: To estimate health outcomes, costs, and cost-effectiveness of LTBI testing and treatment among non-US born residents with and without medical comorbidities. Design, Setting, and Participants: Decision analytic tree and Markov cohort simulation model among non-US born residents with no comorbidities, with diabetes, with HIV infection, or with end-stage renal disease (ESRD) using a health care sector perspective with 3% annual discounting...
October 16, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29016903/screening-for-latent-tuberculosis-in-uk-health-care-workers
#11
M Henderson, S J Howard
Background: Active tuberculosis (TB) infection was diagnosed in two health care workers (HCWs) originally from high-incidence countries at a National Health Service (NHS) hospital trust in Northern England. In response, the trust screened current clinical employees from countries with a high TB prevalence for active and latent TB infection (LTBI). Aims: To identify the number of HCWs, within the organization, who are at risk of TB infection. Methods: Clinical employees from countries with a high TB prevalence (those described by the World Health Organization as having an incidence of >40 cases per 100000 populations) were reviewed...
August 9, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28969786/use-of-an-interferon-gamma-release-assay-igra-to-test-t-cell-responsiveness-to-soluble-leishmania-infantum-antigen-in-whole-blood-of-dogs-from-endemic-areas
#12
Lilia Zribi, Amel F El-Goulli, Meriem Ben-Abid, Mohamed Gharbi, Ines Ben-Sghaier, Imed Boufaden, Karim Aoun, Aïda Bouratbine
Interferon-Gamma (IFN-γ) Release Assays (IGRAs) are easy tests that allow rapid screening of primed memory T-cells immunity in response to antigen. The aim of this study was to use IGRA to assess IFN-γ release in response to Soluble Leishmania infantum antigen (SLA) in whole blood of dogs living in endemic area of visceral leishmaniasis and to interpret IGRA results according to clinical examination, specific anti-Leishmania humoral response and presence of L. infantum DNA in blood. The study was carried out on 56 dogs living in greater Tunis area...
November 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28911359/interferon-gamma-response-to-the-treatment-of-active-pulmonary-and-extra-pulmonary-tuberculosis
#13
L Liang, R Shi, X Liu, X Yuan, S Zheng, G Zhang, W Wang, J Wang, K England, L E Via, Y Cai, L C Goldfeder, L E Dodd, C E Barry, R Y Chen
BACKGROUND: Interferon-gamma (IFN-γ) release assays (IGRAs) are used to diagnose tuberculosis (TB) but not to measure treatment response. OBJECTIVE: To measure IFN-γ response to active anti-tuberculosis treatment. DESIGN: Patients from the Henan Provincial Chest Hospital, Henan, China, with TB symptoms and/or signs were enrolled into this prospective, observational cohort study and followed for 6 months of treatment, with blood and sputum samples collected at 0, 2, 4, 6, 8, 16 and 24 weeks...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28859694/usefulness-of-interferon-%C3%AE-release-assay-for-the-diagnosis-of-sputum-smear-negative-pulmonary-and-extra-pulmonary-tb-in-zhejiang-province-china
#14
Lei Ji, Yong-Liang Lou, Zhong-Xiu Wu, Jin-Qin Jiang, Xing-Li Fan, Li-Fang Wang, Xiao-Xiang Liu, Peng Du, Jie Yan, Ai-Hua Sun
BACKGROUND: Quick diagnosis of smear-negative pulmonary tuberculosis (TB) and extra-pulmonary TB are urgently needed in clinical diagnosis. Our research aims to investigate the usefulness of the interferon-γ release assay (IGRA) for the diagnosis of smear-negative pulmonary and extra-pulmonary TB. METHODS: We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients (including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients), 113 extra-pulmonary TB patients, 81 patients with other pulmonary diseases and 100 healthy controls...
September 1, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28841837/decreased-ex-vivo-production-of-interferon-gamma-is-associated-with-severity-and-poor-prognosis-in-patients-with-lupus
#15
Sung Soo Ahn, Eun Seong Park, Joo Sung Shim, Sang-Jun Ha, Beom Seok Kim, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
BACKGROUND: Lupus pathogenesis is closely associated with interferon gamma (IFN-γ), which plays a central role in innate and adaptive immunity. The aim of this study was to evaluate the ex vivo production of IFN-γ after stimulation of peripheral blood mononuclear cells with phytohemagglutinin (PHA) in patients with lupus, according to disease activity. METHODS: This study included 118 patients with lupus who had undergone IFN-γ-releasing assays (IGRAs) to screen for tuberculosis...
August 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28840843/interferon-gamma-release-assay-in-response-to-pe35-ppe68-proteins-a-promising-diagnostic-method-for-diagnosis-of-latent-tuberculosis
#16
Shima Mahmoudi, Babak Pourakbari, Setareh Mamishi
Tuberculosis control relies on the identification and preventive treatment of people who are latently infected with Mycobacterium tuberculosis (Mtb). PE/PPE proteins have been reported to elicit CD4 and/or CD8 responses either in the form of whole recombinant proteins or as individual peptides. Very few of the PE and PPE proteins have been previously tested for responses in patients with TB and healthy donors. This is the first study to evaluate the Interferon Gamma Release Assay (IGRA) after stimulation with PE35 and PPE68...
March 1, 2017: European Cytokine Network
https://www.readbyqxmd.com/read/28837654/immune-characterization-of-the-hbha-specific-response-in-mycobacterium-tuberculosis-infected-patients-with-or-without-hiv-infection
#17
Teresa Chiacchio, Giovanni Delogu, Valentina Vanini, Gilda Cuzzi, Flavio De Maio, Carmela Pinnetti, Alessandro Sampaolesi, Andrea Antinori, Delia Goletti
INTRODUCTION: RD1-based Interferon-γ Release Assays (IGRAs) cannot distinguish latent from active tuberculosis (TB) disease. Conversely, a positive response to heparin-binding haemagglutinin (HBHA)-based IGRAs, among TB-infected subjects, correlates with Mycobacterium tuberculosis (Mtb) containment and low risk of TB progression. The aim of this study was to characterize HBHA-immune responses in HIV-infected and uninfected subjects with active TB or latent TB infection (LTBI). METHODS: 49 subjects were prospectively enrolled: 22 HIV-uninfected (13 TB, 9 LTBI) and 27 HIV-infected (12 HIV-TB, 15 HIV-LTBI)...
2017: PloS One
https://www.readbyqxmd.com/read/28837570/assessment-of-the-influence-of-direct-tobacco-smoke-on-infection-and-active-tb-management
#18
Neus Altet, Irene Latorre, María Ángeles Jiménez-Fuentes, José Maldonado, Israel Molina, Yoel González-Díaz, Celia Milà, Esther García-García, Beatriz Muriel, Raquel Villar-Hernández, Maisem Laabei, Andromeda-Celeste Gómez, Pere Godoy, Maria Luiza de Souza-Galvão, Segismundo Solano, Carlos A Jiménez-Ruiz, Jose Domínguez
BACKGROUND: Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. Consequently, an impaired immune response could affect performance of IFN-γ Release Assays (IGRAs). OBJECTIVE: In the present study, we assess the impact of direct tobacco smoking on radiological manifestations, sputum conversion and immune response to Mycobacterium tuberculosis, analyzing IFN-γ secretion by IGRAs...
2017: PloS One
https://www.readbyqxmd.com/read/28830137/clinical-applications-of-interferon-%C3%AE-releasing-assays-for-cytomegalovirus-to-differentiate-cytomegalovirus-disease-from-bystander-activation-a-pilot-proof-of-concept-study
#19
Sung-Han Kim, Ho-Su Lee, Hyun-Jung Lee, Sun-Mi Kim, Sung Shin, Sang-Hyoung Park, Kyung-Jo Kim, Young-Hoon Kim, Heungsup Sung, Sang-Oh Lee, Sang-Ho Choi, Suk-Kyun Yang, Yang Soo Kim, Jun Hee Woo, Duck-Jong Han
BACKGROUND/AIMS: We evaluated the proposed clinical application of the combined interpretation of host factors and viral factors in two different cytomegalovirus (CMV) co-infection models. METHODS: We prospectively enrolled all human immunodeficiency virus non-infected patients with confirmed Pneumocystitis jirovecii pneumonia (PCP) and those with suspected gastrointestinal CMV disease in a tertiary hospital. All patients underwent CMV interferon-γ releasing assay (IGRA) for CMV (T-track CMV, Lophius Biosciences)...
September 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28821234/incident-mycobacterium-tuberculosis-infection-in-household-contacts-of-infectious-tuberculosis-patients-in-brazil
#20
COMPARATIVE STUDY
Edward C Jones-López, Carlos Acuña-Villaorduña, Geisa Fregona, Patricia Marques-Rodrigues, Laura F White, David Jamil Hadad, Lucilia Pereira Dutra-Molina, Solange Vinhas, Avery I McIntosh, Mary Gaeddert, Rodrigo Ribeiro-Rodrigues, Padmini Salgame, Moises Palaci, David Alland, Jerrold J Ellner, Reynaldo Dietze
BACKGROUND: In household contact investigations of tuberculosis (TB), a second tuberculin skin test (TST) obtained several weeks after a first negative result consistently identifies individuals that undergo TST conversion. It remains unclear whether this delay in M. tuberculosis infection is related to differences in the infectious exposure, TST boosting, partial host resistance, or some other factor. METHODS: We conducted a household contact study Vitória, Brazil...
August 18, 2017: BMC Infectious Diseases
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