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https://www.readbyqxmd.com/read/28748193/infliximab-therapy-leading-to-pulmonary-tuberculosis-in-a-patient-with-negative-interferon-%C3%AE-release-assay-igra-based-quantiferon-gold-test
#1
Soni Parita, Kumar Vivek, Kamholz Stephan, Pascal William, Kupfer Yizhak
Infliximab therapy is associated with higher rates of active tuberculosis (TB), particularly extrapulmonary and disseminated forms with unusual symptoms. We report the case of a 66-year-old man with Crohn's disease who developed TB mimicking lung cancer on imaging. He presented with cough and fever of 2 weeks' duration shortly after starting infliximab. Computed tomography of the chest revealed a 7.0 × 3.2 cm(2) pleural-based mass, highly suspicious for malignancy. Histopathological examination confirmed the diagnosis of TB...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28746533/frequency-of-indeterminate-results-from-an-interferon-gamma-release-assay-among-hiv-infected-individuals
#2
Sandra Maria do Valle Leone de Oliveira, Anete Trajman, Anamaria Mello Miranda Paniago, Ana Rita Coimbra Motta-Castro, Antonio Ruffino-Netto, Ethel Leonor Noia Maciel, Julio Croda, Maria da Gloria Bonecini-Almeida
Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records. The association of those variables with indeterminate results was analyzed by calculating the adjusted ORs in a multivariate logistic regression model...
May 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28743918/active-tuberculosis-incidence-and-characteristics-in-patients-treated-with-tumor-necrosis-factor-antagonists-according-to-latent-tuberculosis-infection
#3
Eun Hye Lee, Young Ae Kang, Ah Young Leem, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Song Yee Kim
This study aimed to determine the incidence and characteristics of active tuberculosis (TB) in patients treated with tumor necrosis factor (TNF) antagonists according to baseline latent tuberculosis infection (LTBI). Data were retrospectively obtained from 702 patients aged ≥20 years treated with TNF antagonists between November 2005 and June 2016 at Severance Hospital, a tertiary referral hospital in Seoul, South Korea. The interferon-gamma release assay (IGRA) with or without a tuberculin skin test (TST) was used to diagnose LTBI...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739436/efficacy-of-isoniazid-salvage-therapy-for-latent-tuberculosis-infection-in-patients-with-immune-mediated-inflammatory-disorders-a-retrospective-cohort-study-in-taiwan
#4
Shiang-Fen Huang, Ming-Han Chen, Fu-Der Wang, Chang-Youh Tsai, Chang-Phone Fung, Wei-Juin Su
BACKGROUND: Active tuberculosis (TB) in patients with latent tuberculosis infection (LTBI) was associated with use of biological agents for immune-mediated inflammatory disorders (IMIDs). For decreasing active TB, isoniazid prophylaxis therapy was administered before biologic therapy among IMID patients with LTBI. However, for patients who had been received biologics for a long time with unknown status of LTBI or exposure history of active TB, the prevalence of LTBI and efficacy of isoniazid therapy were unclear...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28732078/impact-of-diabetes-mellitus-on-indeterminate-results-of-the-quantiferon-tb-gold-in-tube-test-a-propensity-score-matching-analysis
#5
Hong-Joon Shin, Tae-Ok Kim, Hyung-Joo Oh, Ha-Young Park, Jin-Sun Chang, Seong Ahn, Yu-Il Kim, Sung-Chul Lim, Yong-Soo Kwon
BACKGROUND: The sensitivity of interferon-gamma release assays (IGRAs) in the detection of Mycobacterium tuberculosis infection could be affected by conditions of immune dysregulation. For this reason, diabetes mellitus (DM) may increase the frequency of indeterminate results of IGRAs. However, there have been inconsistent reports of role of DM on indeterminate IGRA results. METHODS: We retrospectively reviewed all patients who underwent QuantiFERON-TB Gold In-Tube testing (QFT-GIT) at Chonnam National University Hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28720611/prevalence-and-risk-factors-of-latent-tuberculosis-infection-in-africa-a-systematic-review-and-meta-analysis-protocol
#6
Tariro J Basera, Jabulani Ncayiyana, Mark E Engel
INTRODUCTION: Latent tuberculosis infection (LTBI) remains a major public health problem and one of the major contributors to the pool of active tuberculosis cases. The true burden of LTBI in Africa is not known. Early modelling studies estimate that over 33% of the world's population is infected with latent tuberculosis. We propose conducting a systematic review and a meta-analysis to evaluate the burden and risk factors of LTBI in Africa reported in studies from 2000 to 2017. METHODS AND ANALYSIS: We will include cross-sectional studies, cohort studies and case-control studies estimating either tuberculin skin test (TST) or interferon-gamma release assay (IGRA) confirmed prevalence of LTBI and associated risk factors among people in African countries...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28700283/update-on-immunological-test-quantiferon-tb-gold-contribution-in-the-management-of-tuberculosis-related-ocular-inflammation
#7
S Trad, B Bodaghi, D Saadoun
PURPOSE: To clarify interferon-gamma release assay (IGRA) contributions to intraocular tuberculosis management, according to related TB endemic prevalence. METHODS: Despite extensive investigations, including IGRA, the diagnosis of intraocular tuberculosis (TB) is still challenging and remains mostly presumptive. According to the literature, it appears that management of suspected ocular TB differs significantly based on whether patients are from areas of high TB prevalence or from non-TB-endemic countries...
July 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28670691/the-performance-of-t-cell-xtend-reagent-in-increasing-blood-storage-times-for-interferon-gamma-release-assays
#8
Junlian Li, Yan Liu, Liyamu Ma, Libike Gu, Quan Wang, Miao Xu, Ruiying Ma, Yali Zhang, Zhenping Yang, Junjie Deng, Xing Yi
BACKGROUND: T-cell Xtend (TCX) was introduced to extend the blood storage time for T-SPOT.TB test, a widely used commercial interferon gamma release assay (IGRA) for rapid in vitro tuberculosis. METHODS: A total of 99 Uyghur suspected tuberculosis patients were recruited in this study. T-SPOT.TB test was performed with fresh blood (controls), 36 hours delayed blood and delayed and TCX-treated (at 36 hours) blood from each patient, respectively. RESULTS: White blood cells and lymphocytes proportion in peripheral blood mononuclear cells s and spot-forming cells in positive control wells decreased significantly in delayed blood samples when compared with controls, while this decrease was not detected in TCX-treated group...
July 3, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28667275/tuberculosis-infection-in-rural-labor-migrants-in-shenzhen-china-emerging-challenge-to-tuberculosis-control-during-urbanization
#9
Xiangwei Li, Qianting Yang, Boxuan Feng, Henan Xin, MingXia Zhang, Qunyi Deng, Guofang Deng, Wanshui Shan, Jianrong Yue, Haoran Zhang, Mufei Li, Hengjing Li, Qi Jin, Xinchun Chen, Lei Gao
During China's urbanization process, rural labor migrants have been suggested to be one important bridge population to change urban-rural distribution on tuberculosis (TB) burden. Aiming to estimate the prevalence of TB infection and to track the active disease development in rural labor migrants, a prospective study was conducted in Shenzhen city, southern China. TB infection was detected using interferon-γ release assay (IGRA). Here we mainly report the characteristics of TB infection in the study population based on the baseline survey...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28665059/occupational-risk-of-latent-tuberculosis-infection-in-health-workers-of-14-military-hospitals
#10
Chang Gyo Yoon, Soo Yon Oh, Jin Beom Lee, Mi Hyun Kim, Younsuk Seo, Juyoun Yang, Kyu Jung Bae, Seoyean Hong, Eun Suk Yang, Hee Jin Kim
Tuberculosis (TB) is a known occupational risk to health workers. Identifying risk factors in health care settings is critical to the prevention of TB for health workers and patients. In 2014, we carried out a TB screening and survey for 902 health workers from 14 selected military hospitals to determine the prevalence rate of latent tuberculosis infection (LTBI) as well as occupational risk factors. Of all subjects, 19.5% reported having provided TB patient care for 1 year or more (176/902), and 26.9% (243/902) were positive for the tuberculin skin test (TST) (10 mm or more of induration)...
August 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28610788/evaluation-of-antigen-specific-interleukin-1%C3%AE-as-a-biomarker-to-detect-cattle-infected-with-mycobacterium-bovis
#11
Mahmoud M Elnaggar, Gaber S Abdellrazeq, Alaa Elsisy, Asmaa H Mahmoud, Abdelrazeq Shyboub, Martina Sester, Samy A Khaliel, Mahavir Singh, Helmy A Torky, William C Davis
Bovine tuberculosis (bTB) is a major world-wide health problem that has been difficult to control, due to the lack of an effective vaccine and limited ability of the tuberculin skin test (TST) and the ancillary whole blood interferon-gamma (IFN-γ) release assay (IGRA) to detect all infected animals. A 6 h cytokine flow cytometric IFN-γ (CFC) assay was developed in effort to overcome these limitations and expand methods for studying the mechanisms of bTB immunopathogenesis. The present study was conducted to evaluate IL-1β as a biomarker to use in conjunction with the IFN-γ CFC assay to improve the diagnostic accuracy for bTB...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28578219/identification-of-new-antigen-candidates-for-the-early-diagnosis-of-mycobacterium-avium-subsp-paratuberculosis-infection-in-goats
#12
Armel Souriau, Sandrine Freret, Benjamin Foret, Peter T J Willemsen, Douwe Bakker, Laurence A Guilloteau
Currently Mycobacterium avium subsp. paratuberculosis (MAP) infection is diagnosed through indirect tests based on the immune response induced by the infection. The antigens commonly used in IFN-γ release assays (IGRA) are purified protein derivative tuberculins (PPD). However, PPDs, lack both specificity (Sp) and sensitivity (Se) in the early phase of infection. This study investigated the potential of 16 MAP recombinant proteins and five lipids to elicit the release of IFN-γ in goats from herds with or without a history of paratuberculosis...
May 26, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28576466/are-additive-effects-of-dietary-surfactants-on-intestinal-tight-junction-integrity-an-overlooked-human-health-risk-a-mixture-study-on-caco-2-monolayers
#13
Anders Glynn, Annachiara Malin Igra, Salomon Sand, Nils Gunnar Ilbäck, Karl Erik Hellenäs, Johan Rosén, Bitte Aspenström-Fagerlund
Surfactants may cause dysfunction of intestinal tight junctions (TJs), which is a common feature of intestinal autoimmune diseases. Effects of dietary surfactants on TJ integrity, measured as trans-epithelial resistance (TEER), were studied in Caco-2 cell monolayers. Cytotoxicity was assessed as apical LDH leakage. Monolayers were apically exposed for 60 min to the dietary surfactants solanine and chaconine (SC, potato glycoalkaloids, 0-0.25 mM), perfluorooctane sulfonic acid (PFOS, industrial contaminant, 0-0...
May 30, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28543876/application-of-molecular-microbiological-and-immunological-tests-for-the-diagnosis-of-bone-and-joint-tuberculosis
#14
Yinghua Tang, Lianli Yin, Shifu Tang, Hongyu Zhang, Jihui Lan
BACKGROUND: To evaluate the application of interferon gamma release assay (IGRA), rifampicin resistant real-time fluorescence quantitative PCR technique Xpert Mycobacterium tuberculosis/rifampicin (Xpert MTB/RIF), and the levels of TNF-α and TGF-β in the diagnosis of bone and joint tuberculosis. METHODS: Eighty-six patients with bone and joint tuberculosis, diagnosed by pathology or microbiology, were examined by Xpert MTB/RIF and IGRA (T-SPOT. TB) for Mycobacterium tuberculosis infection, and the TNF-α and TGF-β levels of the patients were measured...
May 22, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28531231/utility-of-th1-cell-immune-responses-for-distinguishing-active-tuberculosis-from-non-active-tuberculosis-a-case-control-study
#15
Lifan Zhang, Xinhe Cheng, Sainan Bian, Yanhua Song, Qiang Li, Mengqiu Gao, Yueqiu Zhang, Xiaochun Shi, Xiaoqing Liu
Currently available Interferon-γ release assay (IGRA) cannot reliably differentiate active TB (ATB) from non-active TB (non-ATB). A study was performed to evaluate the value of Mycobacterium tuberculosis (MTB) specific Th1 cell immune responses which test IFN-γ and IL-2 simultaneous for differentiating ATB from non-ATB. Forty-nine newly diagnosed inpatients with ATB (26 pulmonary TB and 23 extrapulmonary TB) were enrolled as the ATB group. Forty-five volunteers with latent tuberculosis infection (LTBI) and twenty with evidence of previous TB were enrolled during the same period as the non-ATB group...
2017: PloS One
https://www.readbyqxmd.com/read/28521263/gamma-interferon-responses-to-proteome-determined-specific-recombinant-proteins-in-cattle-experimentally-and-naturally-infected-with-paratuberculosis
#16
Valerie Hughes, Jim McNair, Samuel Strain, Claire Barry, Joyce McLuckie, Mintu Nath, George Caldow, Karen Stevenson
Johne's disease (JD), is a fatal enteritis of animals caused by infection with Mycobacterium avium subspecies paratuberculosis (Map). Diagnosis of subclinical JD is problematic as test sensitivity is limited. Th1 responses to Map are activated early, thus detection of a cell-mediated response, indicated by measuring interferon gamma (IFN-γ) stimulated by mycobacterial antigens, may give the first indication of sub-clinical infection. Crude extracts of Map (PPDJ) have been used to detect the cell-mediated response in infected cattle...
April 29, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28498853/safety-and-immunogenicity-of-an-inactivated-whole-cell-tuberculosis-vaccine-booster-in-adults-primed-with-bcg-a-randomized-controlled-trial-of-dar-901
#17
C Fordham von Reyn, Timothy Lahey, Robert D Arbeit, Bernard Landry, Leway Kailani, Lisa V Adams, Brenda C Haynes, Todd Mackenzie, Wendy Wieland-Alter, Ruth I Connor, Sue Tvaroha, David A Hokey, Ann M Ginsberg, Richard Waddell
BACKGROUND: Development of a tuberculosis vaccine to boost BCG is a major international health priority. SRL172, an inactivated whole cell booster derived from a non-tuberculous mycobacterium, is the only new vaccine against tuberculosis to have demonstrated efficacy in a Phase 3 trial. In the present study we sought to determine if a three-dose series of DAR-901 manufactured from the SRL172 master cell bank by a new, scalable method was safe and immunogenic. METHODS: We performed a single site, randomized, double-blind, controlled, Phase 1 dose escalation trial of DAR-901 at Dartmouth-Hitchcock Medical Center in the United States...
2017: PloS One
https://www.readbyqxmd.com/read/28487230/assessment-of-antigenic-supplementation-of-bovine-purified-protein-derivative-for-diagnosis-of-subclinical-infection-with-mycobacterium-bovis-in-cattle
#18
A H Alvarez, A Gutiérrez-Ortega, V Gómez-Entzin, G Pérez-Mayorga, J Naranjo-Bastién, V González-Martínez, F Milián-Suazo, M Martínez-Velázquez, S Herrera-Rodríguez, E Hinojoza-Loza
Bovine tuberculosis (bTB) is usually diagnosed in vivo and ex vivo on the basis of delayed hypersensitivity reactions with a complex pool of antigens named bovine tuberculin (PPDB). The IFN-γ release assay (IGRA) for bTB is a blood-based assay that improves detection of infected cattle at early stages that escape skin testing. Improvements to IFN-γ testing with specific proteins have been performed to increase sensitivity. DosR regulon-related antigens are well known mycobacterial proteins expressed during the non-replicative phases of infection, this has been useful to improve the diagnosis of subclinical forms of TB in suspected individuals...
July 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28486818/tuberculosis-screening-among-hiv-infected-patients-tuberculin-skin-test-vs-interferon-gamma-release-assay
#19
J W Adams, C J Howe, A C Andrews, S L Allen, C Vinnard
National guidelines recommend screening for latent tuberculosis infection (LTBI) in all HIV-infected patients. Thus, the objective of this study was to measure protocol adherence to national guidelines regarding LTBI screening for HIV-infected patients entering care at an urban primary care clinic specializing in HIV care, identify clinical and other characteristics associated with adherence, and determine whether transitioning from the tuberculin skin test (TST) to the interferon-gamma release assay (IGRA) improved adherence...
May 9, 2017: AIDS Care
https://www.readbyqxmd.com/read/28482964/the-sensitivity-of-the-quantiferon-%C3%A2-tb-gold-plus-assay-in-zambian-adults-with-active-tuberculosis
#20
L Telisinghe, M Amofa-Sekyi, K Maluzi, D Kaluba-Milimo, M Cheeba-Lengwe, K Chiwele, B Kosloff, S Floyd, S-L Bailey, H Ayles
SETTING AND OBJECTIVE: To investigate the sensitivity of the new interferon-gamma release assay (IGRA), QuantiFERON®-TB Gold Plus (QFT-Plus), for active TB (used as a surrogate for latent tuberculous infection) in a Zambian TB clinic. DESIGN: Consecutive smear or Xpert® MTB/RIF-positive adult (age 18 years) pulmonary TB patients were recruited between June 2015 and March 2016. Venous blood was tested using QFT-Plus. The sensitivity was defined as the number positive divided by the total number tested...
June 1, 2017: International Journal of Tuberculosis and Lung Disease
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