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https://www.readbyqxmd.com/read/28911359/interferon-gamma-response-to-the-treatment-of-active-pulmonary-and-extra-pulmonary-tuberculosis
#1
L Liang, R Shi, X Liu, X Yuan, S Zheng, G Zhang, W Wang, J Wang, K England, L E Via, Y Cai, L C Goldfeder, L E Dodd, C E Barry, R Y Chen
BACKGROUND: Interferon-gamma (IFN-γ) release assays (IGRAs) are used to diagnose tuberculosis (TB) but not to measure treatment response. OBJECTIVE: To measure IFN-γ response to active anti-tuberculosis treatment. DESIGN: Patients from the Henan Provincial Chest Hospital, Henan, China, with TB symptoms and/or signs were enrolled into this prospective, observational cohort study and followed for 6 months of treatment, with blood and sputum samples collected at 0, 2, 4, 6, 8, 16 and 24 weeks...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28859694/usefulness-of-interferon-%C3%AE-release-assay-for-the-diagnosis-of-sputum-smear-negative-pulmonary-and-extra-pulmonary-tb-in-zhejiang-province-china
#2
Lei Ji, Yong-Liang Lou, Zhong-Xiu Wu, Jin-Qin Jiang, Xing-Li Fan, Li-Fang Wang, Xiao-Xiang Liu, Peng Du, Jie Yan, Ai-Hua Sun
BACKGROUND: Quick diagnosis of smear-negative pulmonary tuberculosis (TB) and extra-pulmonary TB are urgently needed in clinical diagnosis. Our research aims to investigate the usefulness of the interferon-γ release assay (IGRA) for the diagnosis of smear-negative pulmonary and extra-pulmonary TB. METHODS: We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients (including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients), 113 extra-pulmonary TB patients, 81 patients with other pulmonary diseases and 100 healthy controls...
September 1, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28841837/decreased-ex-vivo-production-of-interferon-gamma-is-associated-with-severity-and-poor-prognosis-in-patients-with-lupus
#3
Sung Soo Ahn, Eun Seong Park, Joo Sung Shim, Sang-Jun Ha, Beom Seok Kim, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
BACKGROUND: Lupus pathogenesis is closely associated with interferon gamma (IFN-γ), which plays a central role in innate and adaptive immunity. The aim of this study was to evaluate the ex vivo production of IFN-γ after stimulation of peripheral blood mononuclear cells with phytohemagglutinin (PHA) in patients with lupus, according to disease activity. METHODS: This study included 118 patients with lupus who had undergone IFN-γ-releasing assays (IGRAs) to screen for tuberculosis...
August 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28840843/interferon-gamma-release-assay-in-response-to-pe35-ppe68-proteins-a-promising-diagnostic-method-for-diagnosis-of-latent-tuberculosis
#4
Shima Mahmoudi, Babak Pourakbari, Setareh Mamishi
Tuberculosis control relies on the identification and preventive treatment of people who are latently infected with Mycobacterium tuberculosis (Mtb). PE/PPE proteins have been reported to elicit CD4 and/or CD8 responses either in the form of whole recombinant proteins or as individual peptides. Very few of the PE and PPE proteins have been previously tested for responses in patients with TB and healthy donors. This is the first study to evaluate the Interferon Gamma Release Assay (IGRA) after stimulation with PE35 and PPE68...
March 1, 2017: European Cytokine Network
https://www.readbyqxmd.com/read/28837654/immune-characterization-of-the-hbha-specific-response-in-mycobacterium-tuberculosis-infected-patients-with-or-without-hiv-infection
#5
Teresa Chiacchio, Giovanni Delogu, Valentina Vanini, Gilda Cuzzi, Flavio De Maio, Carmela Pinnetti, Alessandro Sampaolesi, Andrea Antinori, Delia Goletti
INTRODUCTION: RD1-based Interferon-γ Release Assays (IGRAs) cannot distinguish latent from active tuberculosis (TB) disease. Conversely, a positive response to heparin-binding haemagglutinin (HBHA)-based IGRAs, among TB-infected subjects, correlates with Mycobacterium tuberculosis (Mtb) containment and low risk of TB progression. The aim of this study was to characterize HBHA-immune responses in HIV-infected and uninfected subjects with active TB or latent TB infection (LTBI). METHODS: 49 subjects were prospectively enrolled: 22 HIV-uninfected (13 TB, 9 LTBI) and 27 HIV-infected (12 HIV-TB, 15 HIV-LTBI)...
2017: PloS One
https://www.readbyqxmd.com/read/28837570/assessment-of-the-influence-of-direct-tobacco-smoke-on-infection-and-active-tb-management
#6
Neus Altet, Irene Latorre, María Ángeles Jiménez-Fuentes, José Maldonado, Israel Molina, Yoel González-Díaz, Celia Milà, Esther García-García, Beatriz Muriel, Raquel Villar-Hernández, Maisem Laabei, Andromeda-Celeste Gómez, Pere Godoy, Maria Luiza de Souza-Galvão, Segismundo Solano, Carlos A Jiménez-Ruiz, Jose Domínguez
BACKGROUND: Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. Consequently, an impaired immune response could affect performance of IFN-γ Release Assays (IGRAs). OBJECTIVE: In the present study, we assess the impact of direct tobacco smoking on radiological manifestations, sputum conversion and immune response to Mycobacterium tuberculosis, analyzing IFN-γ secretion by IGRAs...
2017: PloS One
https://www.readbyqxmd.com/read/28830137/clinical-applications-of-interferon-%C3%AE-releasing-assays-for-cytomegalovirus-to-differentiate-cytomegalovirus-disease-from-bystander-activation-a-pilot-proof-of-concept-study
#7
Sung-Han Kim, Ho-Su Lee, Hyun-Jung Lee, Sun-Mi Kim, Sung Shin, Sang-Hyoung Park, Kyung-Jo Kim, Young-Hoon Kim, Heungsup Sung, Sang-Oh Lee, Sang-Ho Choi, Suk-Kyun Yang, Yang Soo Kim, Jun Hee Woo, Duck-Jong Han
BACKGROUND/AIMS: We evaluated the proposed clinical application of the combined interpretation of host factors and viral factors in two different cytomegalovirus (CMV) co-infection models. METHODS: We prospectively enrolled all human immunodeficiency virus non-infected patients with confirmed Pneumocystitis jirovecii pneumonia (PCP) and those with suspected gastrointestinal CMV disease in a tertiary hospital. All patients underwent CMV interferon-γ releasing assay (IGRA) for CMV (T-track CMV, Lophius Biosciences)...
September 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28821234/incident-mycobacterium-tuberculosis-infection-in-household-contacts-of-infectious-tuberculosis-patients-in-brazil
#8
Edward C Jones-López, Carlos Acuña-Villaorduña, Geisa Fregona, Patricia Marques-Rodrigues, Laura F White, David Jamil Hadad, Lucilia Pereira Dutra-Molina, Solange Vinhas, Avery I McIntosh, Mary Gaeddert, Rodrigo Ribeiro-Rodrigues, Padmini Salgame, Moises Palaci, David Alland, Jerrold J Ellner, Reynaldo Dietze
BACKGROUND: In household contact investigations of tuberculosis (TB), a second tuberculin skin test (TST) obtained several weeks after a first negative result consistently identifies individuals that undergo TST conversion. It remains unclear whether this delay in M. tuberculosis infection is related to differences in the infectious exposure, TST boosting, partial host resistance, or some other factor. METHODS: We conducted a household contact study Vitória, Brazil...
August 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28754530/tuberculosis-in-children-from-diagnosis-to-decision-to-treat
#9
S Ramos, R Gaio, F Ferreira, J Paulo Leal, S Martins, J Vasco Santos, I Carvalho, R Duarte
SETTING: Confirmation of tuberculosis (TB) in children is difficult, so clinicians use different procedures when deciding to treat. OBJECTIVE: Identify criteria to initiate and maintain TB treatment in children younger than 5 years-old, without diagnosis confirmation. DESIGN: A web-based survey was distributed by email to the corresponding authors of journal articles on childhood TB. The observations were clustered into disjoint groups, and analyzed by Ward's method...
July 25, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28751171/use-of-ifn-%C3%AE-and-ip-10-detection-in-the-diagnosis-of-latent-tuberculosis-infection-in-patients-with-inflammatory-rheumatic-diseases
#10
Raquel Villar-Hernández, Irene Latorre, Sonia Mínguez, Jéssica Díaz, Esther García-García, Beatriz Muriel-Moreno, Alicia Lacoma, Cristina Prat, Alex Olivé, Morten Ruhwald, Lourdes Mateo, José Domínguez
OBJECTIVES: Biologic agents are used against rheumatic diseases, however, they increase the risk of developing severe infections and diseases such as tuberculosis. We aimed to determine the benefits of IP-10 detection to diagnose latent tuberculosis infection (LTBI) in patients with inflammatory rheumatic diseases on different immunosuppressive drug regimens, and compare these results with IFN-γ detection. MATERIALS AND METHODS: We included 64 patients with inflammatory rheumatic diseases...
July 25, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28748193/infliximab-therapy-leading-to-pulmonary-tuberculosis-in-a-patient-with-negative-interferon-%C3%AE-release-assay-igra-based-quantiferon-gold-test
#11
Soni Parita, Kumar Vivek, Kamholz Stephan, Pascal William, Kupfer Yizhak
Infliximab therapy is associated with higher rates of active tuberculosis (TB), particularly extrapulmonary and disseminated forms with unusual symptoms. We report the case of a 66-year-old man with Crohn's disease who developed TB mimicking lung cancer on imaging. He presented with cough and fever of 2 weeks' duration shortly after starting infliximab. Computed tomography of the chest revealed a 7.0 × 3.2 cm(2) pleural-based mass, highly suspicious for malignancy. Histopathological examination confirmed the diagnosis of TB...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28746533/frequency-of-indeterminate-results-from-an-interferon-gamma-release-assay-among-hiv-infected-individuals
#12
Sandra Maria do Valle Leone de Oliveira, Anete Trajman, Anamaria Mello Miranda Paniago, Ana Rita Coimbra Motta-Castro, Antonio Ruffino-Netto, Ethel Leonor Noia Maciel, Julio Croda, Maria da Gloria Bonecini-Almeida
Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records. The association of those variables with indeterminate results was analyzed by calculating the adjusted ORs in a multivariate logistic regression model...
May 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28743918/active-tuberculosis-incidence-and-characteristics-in-patients-treated-with-tumor-necrosis-factor-antagonists-according-to-latent-tuberculosis-infection
#13
Eun Hye Lee, Young Ae Kang, Ah Young Leem, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Song Yee Kim
This study aimed to determine the incidence and characteristics of active tuberculosis (TB) in patients treated with tumor necrosis factor (TNF) antagonists according to baseline latent tuberculosis infection (LTBI). Data were retrospectively obtained from 702 patients aged ≥20 years treated with TNF antagonists between November 2005 and June 2016 at Severance Hospital, a tertiary referral hospital in Seoul, South Korea. The interferon-gamma release assay (IGRA) with or without a tuberculin skin test (TST) was used to diagnose LTBI...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739436/efficacy-of-isoniazid-salvage-therapy-for-latent-tuberculosis-infection-in-patients-with-immune-mediated-inflammatory-disorders-a-retrospective-cohort-study-in-taiwan
#14
Shiang-Fen Huang, Ming-Han Chen, Fu-Der Wang, Chang-Youh Tsai, Chang-Phone Fung, Wei-Juin Su
BACKGROUND: Active tuberculosis (TB) in patients with latent tuberculosis infection (LTBI) was associated with use of biological agents for immune-mediated inflammatory disorders (IMIDs). For decreasing active TB, isoniazid prophylaxis therapy was administered before biologic therapy among IMID patients with LTBI. However, for patients who had been received biologics for a long time with unknown status of LTBI or exposure history of active TB, the prevalence of LTBI and efficacy of isoniazid therapy were unclear...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28732078/impact-of-diabetes-mellitus-on-indeterminate-results-of-the-quantiferon-tb-gold-in-tube-test-a-propensity-score-matching-analysis
#15
Hong-Joon Shin, Tae-Ok Kim, Hyung-Joo Oh, Ha-Young Park, Jin-Sun Chang, Seong Ahn, Yu-Il Kim, Sung-Chul Lim, Yong-Soo Kwon
BACKGROUND: The sensitivity of interferon-gamma release assays (IGRAs) in the detection of Mycobacterium tuberculosis infection could be affected by conditions of immune dysregulation. For this reason, diabetes mellitus (DM) may increase the frequency of indeterminate results of IGRAs. However, there have been inconsistent reports of role of DM on indeterminate IGRA results. METHODS: We retrospectively reviewed all patients who underwent QuantiFERON-TB Gold In-Tube testing (QFT-GIT) at Chonnam National University Hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28720611/prevalence-and-risk-factors-of-latent-tuberculosis-infection-in-africa-a-systematic-review-and-meta-analysis-protocol
#16
Tariro J Basera, Jabulani Ncayiyana, Mark E Engel
INTRODUCTION: Latent tuberculosis infection (LTBI) remains a major public health problem and one of the major contributors to the pool of active tuberculosis cases. The true burden of LTBI in Africa is not known. Early modelling studies estimate that over 33% of the world's population is infected with latent tuberculosis. We propose conducting a systematic review and a meta-analysis to evaluate the burden and risk factors of LTBI in Africa reported in studies from 2000 to 2017. METHODS AND ANALYSIS: We will include cross-sectional studies, cohort studies and case-control studies estimating either tuberculin skin test (TST) or interferon-gamma release assay (IGRA) confirmed prevalence of LTBI and associated risk factors among people in African countries...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28700283/update-on-immunological-test-quantiferon-tb-gold-contribution-in-the-management-of-tuberculosis-related-ocular-inflammation
#17
S Trad, B Bodaghi, D Saadoun
PURPOSE: To clarify interferon-gamma release assay (IGRA) contributions to intraocular tuberculosis management, according to related TB endemic prevalence. METHODS: Despite extensive investigations, including IGRA, the diagnosis of intraocular tuberculosis (TB) is still challenging and remains mostly presumptive. According to the literature, it appears that management of suspected ocular TB differs significantly based on whether patients are from areas of high TB prevalence or from non-TB-endemic countries...
July 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28670691/the-performance-of-t-cell-xtend-reagent-in-increasing-blood-storage-times-for-interferon-gamma-release-assays
#18
Junlian Li, Yan Liu, Liyamu Ma, Libike Gu, Quan Wang, Miao Xu, Ruiying Ma, Yali Zhang, Zhenping Yang, Junjie Deng, Xing Yi
BACKGROUND: T-cell Xtend (TCX) was introduced to extend the blood storage time for T-SPOT.TB test, a widely used commercial interferon gamma release assay (IGRA) for rapid in vitro tuberculosis. METHODS: A total of 99 Uyghur suspected tuberculosis patients were recruited in this study. T-SPOT.TB test was performed with fresh blood (controls), 36 hours delayed blood and delayed and TCX-treated (at 36 hours) blood from each patient, respectively. RESULTS: White blood cells and lymphocytes proportion in peripheral blood mononuclear cells s and spot-forming cells in positive control wells decreased significantly in delayed blood samples when compared with controls, while this decrease was not detected in TCX-treated group...
July 3, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28667275/tuberculosis-infection-in-rural-labor-migrants-in-shenzhen-china-emerging-challenge-to-tuberculosis-control-during-urbanization
#19
Xiangwei Li, Qianting Yang, Boxuan Feng, Henan Xin, MingXia Zhang, Qunyi Deng, Guofang Deng, Wanshui Shan, Jianrong Yue, Haoran Zhang, Mufei Li, Hengjing Li, Qi Jin, Xinchun Chen, Lei Gao
During China's urbanization process, rural labor migrants have been suggested to be one important bridge population to change urban-rural distribution on tuberculosis (TB) burden. Aiming to estimate the prevalence of TB infection and to track the active disease development in rural labor migrants, a prospective study was conducted in Shenzhen city, southern China. TB infection was detected using interferon-γ release assay (IGRA). Here we mainly report the characteristics of TB infection in the study population based on the baseline survey...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28665059/occupational-risk-of-latent-tuberculosis-infection-in-health-workers-of-14-military-hospitals
#20
Chang Gyo Yoon, Soo Yon Oh, Jin Beom Lee, Mi Hyun Kim, Younsuk Seo, Juyoun Yang, Kyu Jung Bae, Seoyean Hong, Eun Suk Yang, Hee Jin Kim
Tuberculosis (TB) is a known occupational risk to health workers. Identifying risk factors in health care settings is critical to the prevention of TB for health workers and patients. In 2014, we carried out a TB screening and survey for 902 health workers from 14 selected military hospitals to determine the prevalence rate of latent tuberculosis infection (LTBI) as well as occupational risk factors. Of all subjects, 19.5% reported having provided TB patient care for 1 year or more (176/902), and 26.9% (243/902) were positive for the tuberculin skin test (TST) (10 mm or more of induration)...
August 2017: Journal of Korean Medical Science
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