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https://www.readbyqxmd.com/read/29681580/cancer-incidence-and-mortality-patterns-in-luwan-district-of-shanghai-during-2002-2011
#1
Jue Wang, Shuna Gao, Yejing Wang, Jianjun Zhou, Jing Lin, Ling Wang, Yan Du
Cancer has become the leading cause of death and a major burden to public health in China. The current study analyzed the composition, incidence, mortality, and temporal trends for some major cancer types among permanent residents in Luwan district of Shanghai from 2002 to 2011, so as to provide data for cancer research. Data were collected from the database of cancer registration and management system in Shanghai. Number of new cases, number of deaths, incidence, and mortality of each cancer type were calculated...
April 22, 2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29662617/premature-ovarian-aging-in-brca-carriers-a-prototype-of-systemic-precocious-aging
#2
Irit Ben-Aharon, Mattan Levi, David Margel, Rinat Yerushalmi, Shulamith Rizel, Shlomit Perry, Eran Sharon, Noa Hasky, Ronit Abir, Benny Fisch, Ana Tobar, Ruth Shalgi, Salomon Marcello Stemmer
Purpose: Though former evidence implies a correlation of breast cancer susceptibility gene ( BRCA ) mutation with reduced ovarian reserve, the data is yet inconsistent. Our aim was to investigate biomarkers of ovarian aging in a cohort of young healthy carriers of the BRCA mutation. We hypothesized that the role played by BRCA genes in aging pathways is not exclusive to the ovary. Experimental Design: Healthy female BRCA carriers, 40 years or younger and healthy male BRCA carriers, 50 years or younger, were enrolled in the study...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29659187/bioequivalence-of-oral-formulations-of-anastrozole-in-healthy-chinese-male-volunteers-a-randomized-single-dose-two-period-two-sequence-crossover-study
#3
Jiangying Chen, Jialang Zhuang, Jingguo Wu, Xiaoyan Chen, Xueding Wang, Lihui Huang, Guixiong Zeng, Jie Chen, Xiaoxing Liao, Xiao Chen, Zhongfu Ma, Guoping Zhong, Min Huang, Dafang Zhong, Xianglan Zhao
Anastrozole is currently used as first-line treatment in locally advanced or metastatic breast cancer. A generic anastrozole tablet was developed to offer an alternative to the marketed tablet formulation. The aim of the current study was to evaluate the bioequivalence between the test and reference formulations of anastrozole in a single-dose, 2-period, 2-sequence crossover study with a 14-day washout interval. A total of 20 healthy male Chinese volunteers were enrolled and completed the study, after oral administration of a single dose of 1...
April 16, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29657890/pain-flare-after-stereotactic-radiosurgery-for-spine-metastases
#4
Ehsan H Balagamwala, Mihir Naik, Chandana A Reddy, Lilyana Angelov, John H Suh, Toufik Djemil, Anthony Magnelli, Samuel T Chao
Purpose: Understanding of pain flare (PF) following spine stereotactic radiosurgery (sSRS) is lacking. This study sought to determine the incidence and risk factors associated with PF following single fraction sSRS. Materials/methods: An IRB-approved database was compiled to include patients who underwent sSRS. Patient and disease characteristics as well as treatment and dosimetric details were collected retrospectively. Pain relief post-sSRS was prospectively collected using the Brief Pain Inventory (BPI)...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29650746/comprehensive-preventive-care-assessments-for-adults-with-intellectual-and-developmental-disabilities-part-1-how-do-we-know-if-it-is-happening
#5
Glenys Smith, Hélène Ouellette-Kuntz, Michael Green
OBJECTIVE: To determine how best to measure the provision of comprehensive preventive care assessment of adults with intellectual and developmental disabilities (IDD). DESIGN: Cross-sectional study. SETTING: Ontario. PARTICIPANTS: Adults with IDD between 40 and 64 years of age in 2013 and 2014. MAIN OUTCOME MEASURES: Health examination was defined using the Ontario Health Insurance Plan billing data fee code A003 (with diagnostic code 917 or 319) or fee code K131, and the Primary Care Quality Composite Score (PCQS), a measure combining 7 different screening maneuvers (lipid, glucose, breast cancer, cervical cancer, colorectal cancer, eye, and hemoglobin A1c screening), was identified using administrative health data...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29642726/donkey-milk-kefir-induces-apoptosis-and-suppresses-proliferation-of-ehrlich-ascites-carcinoma-by-decreasing-inos-in-mice
#6
Obb Esener, B M Balkan, E I Armutak, A Uvez, G Yildiz, M Hafizoglu, N Yilmazer, E Gurel-Gurevin
Donkey milk and donkey milk kefir exhibit antiproliferative, antimutagenic and antibacterial effects. We investigated the effects of donkey milk and donkey milk kefir on oxidative stress, apoptosis and proliferation in Ehrlich ascites carcinoma (EAC) in mice. Thirty-four adult male Swiss albino mice were divided into four groups as follows: group 1, administered 0.5 ml water; group 2, administered 0.5 ml water + EAC cells; group 3, administered 0.5 ml donkey milk + EAC cells; group 4, administered 0.5 ml donkey milk kefir + EAC cells...
April 12, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29626721/curcumin-loaded-ultradeformable-nanovesicles-as-a-potential-delivery-system-for-breast-cancer-therapy
#7
Salma M Abdel-Hafez, Rania M Hathout, Omaima A Sammour
In the current study, the transdermal route has been investigated to deliver the poorly bioavailable drug; curcumin into the systemic circulation, aiming to target both superficial and subcutaneous tumors such as the breast tumors. Accordingly, different colloidal carriers viz. ultradeformable nanovesicles comprising various penetration enhancers were exploited. Curcumin-loaded deformable vesicles were prepared by the thin film hydration method followed by extrusion. Sodium cholate and Tween 80 were set as standard edge activators and Labrasol, Transcutol, limonene and oleic acid were the penetration enhancers that were evaluated for their efficacy in skin permeation...
March 30, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29623678/routine-histopathological-examination-after-female-to-male-gender-confirming-mastectomy
#8
S M J Van Renterghem, J Van Dorpe, S J Monstrey, J Defreyne, K E Y Claes, M Praet, S L J Verbeke, G G R T'Sjoen, M R Van Bockstal
BACKGROUND: The number of transmen seeking gender-confirming surgery has risen steadily throughout the last decade. Pathologists are increasingly confronted with transmale mastectomy specimens. It is not clear whether routine histopathological examination is useful. This study explored the possible benefit of routine investigation through detailed description of lesions encountered in mastectomy specimens after female-to-male gender-confirming surgery. METHODS: Breast tissue from a cohort of transmen was reviewed...
April 5, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29616377/male-secretory-breast-cancer-case-in-a-6-year-old-boy-with-a-peculiar-gene-duplication-and-review-of-the-literature
#9
REVIEW
M Ghilli, M D Mariniello, C Scatena, L Dosa, G Traficante, A Tamburini, C Caporalini, A M Buccoliero, F Facchini, L Colizzi, A Quattrini Li, E Landucci, G Manca, A G Naccarato, D Caramella, C Favre, M Roncella
PURPOSE: Secretory breast cancer (SBC) is one of the rarest breast cancer (BC), representing the majority of BC in childhood. Nevertheless, it elicits a lot of interest both for the peculiar morphology and the characteristic genetic features. Currently, there is no consensus on optimal treatment strategy. Therefore, it is useful to report every case in order to establish treatment algorithms. METHODS: We describe the case of a 6-year-old boy diagnosed with a SBC, with peculiar genomic and immunohistochemical features...
April 3, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29611755/experience-with-eribulin-in-hr-her2-metastatic-breast-cancer-including-a-male
#10
Maria Del Mar Muñoz Sánchez, Maria Del Carmen Soriano Rodríguez, Maria José Molina Garrido, Ana López-González, Andrés García-Palomo, Laura López-González, Maria Yéssica Plata Fernández, Natalia Luque Caro, Pedro Sánchez Rovira
Numerous patient- and disease-related factors must be considered when deciding a treatment approach for hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer. Hormone therapy (HT) is generally the first option in the absence of compelling reasons for chemotherapy (e.g., rapidly progressive visceral disease). After failure of first-choice HT, alternative HT options are usually attempted until hormone resistance occurs and chemotherapy becomes the treatment of choice...
March 2018: Future Oncology
https://www.readbyqxmd.com/read/29601362/roles-of-family-caregivers-and-perceived-burden-when-caring-for-hospitalized-adult-cancer-patients-perspective-from-a-low-income-country
#11
Joshua K Muliira, Irene B Kizza, Gloria Nakitende
BACKGROUND: Family caregivers (FCGs) of adult cancer patients (ACPs) are typically involved in the entire trajectory of cancer disease, from diagnosis to survivorship or end of life. In developing countries, FCGs are more intensely involved in the process of providing care to the hospitalized ACPs because of lack of adequate cancer care resources. Active performance of tasks to meet the needs of ACPs in the hospital setting is likely to elicit significant caregiver burden. OBJECTIVE: The aim of this study was to explore the tasks performed and the caregiver burden experienced by FCGs of hospitalized ACPs in a sub-Saharan country...
March 30, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29593813/the-role-of-vitamin-e-in-the-prevention-of-zoledronic-acid-induced-nephrotoxicity-in-rats-a-light-and-electron-microscopy-study
#12
İbrahim Unal Sert, Ozcan Kilic, Murat Akand, Lutfi Saglik, Mustafa Cihat Avunduk, Esra Erdemli
Introduction: Bisphosphonates are widely used in metastatic cancer such as prostate and breast cancer, and their nephrotoxic effects have been established previously. In this study we aimed to evaluate both the nephrotoxic effects of zoledronic acid (ZA) and the protective effects of vitamin E (Vit-E) on this process under light and electron microscopy. Material and methods: A total of 30 male Sprague-Dawley rats were divided into 3 groups. The first group constituted the control group...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29590446/cancer-pain-management-education-rectifies-patients-misconceptions-of-cancer-pain-reduces-pain-and-improves-quality-of-life
#13
Su-Jin Koh, Bhumsuk Keam, Min Kyung Hyun, Jeong Ju Seo, Keon Uk Park, Sung Yong Oh, Jinseok Ahn, Ja Youn Lee, JinShil Kim
Objectives: More than half of the patients have reported improper management of breakthrough cancer pain. Empirical evidence is lacking concerning the effectiveness of cancer pain education on breakthrough pain control. This study aimed to examine the effects of individual pain education on pain control, use of short-acting analgesics for breakthrough pain, quality of life outcomes, and rectification of patients' misconceptions regarding cancer pain. Design: A quasi-experimental design was used...
March 26, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29587605/chondritis-of-the-ear-after-docetaxel-carboplatin-chemotherapy
#14
Tae Hoon Kong, Sung Min Han, Young Joon Seo
Docetaxel, derived from the yew tree, belongs to the taxane family of medications. It works by disrupting the normal function of microtubules, thereby stopping cell division. Docetaxel is used in the treatment of ovarian, breast, esophageal, gastric, prostate, lung, and head and neck cancers. Common side effects include hair loss, low blood cell counts, peripheral neuropathy, vomiting, and muscle pain. Auricular chondritis with ear deformity has not been reported previously as a side effect of docetaxel. In this paper, we present the case of a 64-year-old male patient with chondritis accompanied by ear deformity that developed due to docetaxel-carboplatin chemotherapy for non-small cell lung cancer...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29582632/accuracy-of-specimen-radiography-in-assessing-complete-local-excision-with-breast-conservation-surgery
#15
Saira Naz, Imrana Masroor, Shaista Afzal, Waseem Mirza, Sehrish Butt, Zafar Sajjad, Anwar Ahmad
Objective: The aim of this study was to evaluate the accuracy of “X- ray examination of surgically resected specimen‘‘ in assessing complete local excision (CLE). Materials and Methods: In this retrospective cross sectional study, data were collected for all female breast cancer cases who underwent breast-conserving surgery after needle localization of mammographically visible disease. Males, patients with mammographically invisible disease and cases with benign or inconclusive histopathology, those undergoing modified radical mastectomy and individuals with dense breast parenchyma were excluded...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29582162/low-adherence-to-the-western-and-high-adherence-to-the-mediterranean-dietary-patterns-could-prevent-colorectal-cancer
#16
Adela Castelló, Pilar Amiano, Nerea Fernández de Larrea, Vicente Martín, Maria Henar Alonso, Gemma Castaño-Vinyals, Beatriz Pérez-Gómez, Rocío Olmedo-Requena, Marcela Guevara, Guillermo Fernandez-Tardon, Trinidad Dierssen-Sotos, Cristobal Llorens-Ivorra, Jose María Huerta, Rocío Capelo, Tania Fernández-Villa, Anna Díez-Villanueva, Carmen Urtiaga, Jesús Castilla, Jose Juan Jiménez-Moleón, Víctor Moreno, Verónica Dávila-Batista, Manolis Kogevinas, Nuria Aragonés, Marina Pollán
PURPOSE: To assess if the associations found between three previously identified dietary patterns with breast, prostate and gastric cancer are also observed for colorectal cancer (CRC). METHODS: MCC-Spain is a multicase-control study that collected information of 1629 incident cases of CRC and 3509 population-based controls from 11 Spanish provinces. Western, Prudent and Mediterranean data-driven dietary patterns-derived in another Spanish case-control study-were reconstructed in MCC-Spain...
March 26, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29581763/cancer-survival-in-patients-from-a-hospital-based-cancer-registry-china
#17
Jian-Guo Chen, Hai-Zhen Chen, Jian Zhu, Yan-Lei Yang, Yong-Hui Zhang, Pei-Xin Huang, Yong-Sheng Chen, Chao-Yong Zhu, Li-Ping Yang, Kang Shen, Fu-Lin Qiang, Gao-Ren Wang
Purpose: There are few reports on survival rate analysis from hospital-based cancer registries (HBCR) in China, although the National Center of Cancer Registry of China has launched such an effort with the mission to expand the scope of registration and follow-up. Our study aimed to evaluate survival and outcomes of cancer patients from a HBCR in eastern China. Methods: Active and passive follow-up methods were used to obtain information on survival status for all patients from Qidong City and Haimen City in the databases of our hospital-based registrations from 2002 to 2014...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581629/long-term-follow-up-of-male-breast-cancer
#18
N McKinley, S McCain, S Kirk
Introduction: Male breast cancer accounts for less than 1% of breast cancers with published overall and disease free survival being lower than in females. Aims: To determine treatment and long term outcomes for male breast cancer patients in our unit. Methods: A database has been maintained for all breast cancer patients diagnosed in our unit since 1993. Patients were identified using the database and information was collated on patient demographics, tumour pathology, treatment and outcomes using the database and retrospective chart review...
September 2017: Ulster Medical Journal
https://www.readbyqxmd.com/read/29580045/thirty-years-cancer-incidence-data-for-lahore-pakistan-trends-and-patterns-1984-2014
#19
Andleeb Masood, Khalid Masood, Mazhar Hussain, Waqar Ali, Masooma Riaz, Zafar Alauddin, Munir Ahmad, Misbah Masood, Abubaker Shahid
This research was conducted to generate trends and patterns of most common male and female cancers from 1984-2014 for the city population of Lahore Pakistan. Cancer incidence data gathered for different organs were processed through cleaning, integration, transformation, reduction and mining for ultimate representation. Risk of cancer appeared to be continuously increasing among both males and females. Overall, lymphomas and breast cancer are the most common neoplasm in males and females, respectively, in Lahore with almost the highest rates in the Asian Pacific region...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29579884/prevalence-and-survival-of-cancer-after-pancreas-kidney-transplantation
#20
M V Pendón-Ruiz de Mier, M L Agüera, M D Navarro, A Rodriguez-Benot, P Aljama
BACKGROUND: Malignancy is an important cause of mortality in solid organ transplantation. There have been few studies of de novo solid organ malignancy (NSOM) after pancreas-kidney transplantation (PKT). The aim of this study was analyze the prevalence of NSOM and transplant outcomes. METHODS: We studied the development of NSOM after PKT in our center from May 1990 to February 2017. We analyzed demographic characteristics, prevalence of cancer, and survival after cancer diagnosis...
March 2018: Transplantation Proceedings
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