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https://www.readbyqxmd.com/read/29933385/testosterone-treatment-and-the-risk-of-aggressive-prostate-cancer-in-men-with-low-testosterone-levels
#1
Thomas J Walsh, Molly M Shores, Chloe A Krakauer, Christopher W Forsberg, Alexandra E Fox, Kathryn P Moore, Anna Korpak, Susan R Heckbert, Steven B Zeliadt, Chloe E Kinsey, Mary Lou Thompson, Nicholas L Smith, Alvin M Matsumoto
PURPOSE: Testosterone treatment of men with low testosterone is common and, although relatively short-term, has raised concern regarding an increased risk of prostate cancer (CaP). We investigated the association between modest-duration testosterone treatment and incident aggressive CaP. MATERIALS AND METHODS: Retrospective inception cohort study of male Veterans aged 40 to 89 years with a laboratory-defined low testosterone measurement from 2002 to 2011 and recent prostate specific antigen (PSA) testing; excluding those with recent testosterone treatment, prostate or breast cancer, high PSA or prior prostate biopsy...
2018: PloS One
https://www.readbyqxmd.com/read/29928469/high-frequency-of-pathogenic-non-founder-germline-mutations-in-brca1-and-brca2-in-families-with-breast-and-ovarian-cancer-in-a-founder-population
#2
J Maksimenko, A Irmejs, G Trofimovičs, D Bērziņa, E Skuja, G Purkalne, E Miklaševičs, J Gardovskis
Background: Pathogenic BRCA1 founder mutations (c.4035delA, c.5266dupC) contribute to 3.77% of all consecutive primary breast cancers and 9.9% of all consecutive primary ovarian cancers. Identifying germline pathogenic gene variants in patients with primary breast and ovarian cancer could significantly impact the medical management of patients. The aim of the study was to evaluate the rate of pathogenic mutations in the 26 breast and ovarian cancer susceptibility genes in patients who meet the criteria for BRCA1/2 testing and to compare the accuracy of different selection criteria for second-line testing in a founder population...
2018: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29926514/a-pharmacokinetics-phase-1-bioequivalence-study-of-the-trastuzumab-biosimilar-myl-1401o-vs-eu-trastuzumab-and-us-trastuzumab
#3
Cornelius F Waller, Apinya Vutikullird, Tracey E Lawrence, Andrew Shaw, Mark Shiyao Liu, Mark Baczkowski, Rajiv Sharma, Abhijit Barve, Parag Goyal, Charles Donnelly, Nilanjan Sengupta, Eduardo J Pennella
AIMS: Trastuzumab is a humanized monoclonal antibody that binds the human epidermal growth factor receptor 2 (HER2) oncoprotein and is an effective therapy for HER2-overexpressing breast cancer. MYL-1401O is a trastuzumab biosimilar. Here, we report results from a phase 1 study that investigated bioequivalence among MYL-1401O, reference EU-trastuzumab, and US-trastuzumab. METHODS: This single-center, randomized, double-blind, three-arm, parallel-group, phase 1 study was conducted in healthy adult male volunteers...
June 21, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29920139/cancer-among-women-treated-in-the-veterans-affairs-healthcare-system
#4
Leah L Zullig, Karen M Goldstein, Kellie J Sims, Christina D Williams, Michael Chang, Dawn Provenzale, Michael J Kelley
BACKGROUND: The Veterans Affairs (VA) healthcare system is a high-volume provider of cancer care. Women are the fastest growing patient population using VA healthcare services. Quantifying the types of cancers diagnosed among women in the VA is a critical step toward identifying needed healthcare resources for women Veterans with cancer. MATERIALS AND METHODS: We obtained data from the VA Central Cancer Registry for cancers newly diagnosed in calendar year 2010...
June 19, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29909568/association-between-chek2-1100delc-and-breast-cancer-a-systematic-review-and-meta-analysis
#5
REVIEW
Mingming Liang, Yun Zhang, Chenyu Sun, Feras Kamel Rizeq, Min Min, Tingting Shi, Yehuan Sun
INTRODUCTION: The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored. OBJECTIVE: In light of the recent publication of studies on these specific findings, particularly regarding male patients with breast cancer, we performed an updated meta-analysis to investigate a more reliable estimate. METHODS: This meta-analysis included 26 published studies selected in a search of electronic databases up to January 2018, including 118,735 breast cancer cases and 195,807 controls...
June 16, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29907942/distribution-of-21-gene-recurrence-scores-in-male-breast-cancer-in-the-united-states
#6
Ariella M Altman, Scott Kizy, Jianling Yuan, Jason W Denbo, Eric H Jensen, Jane Y C Hui, Todd M Tuttle, Schelomo Marmor
BACKGROUND: The 21-gene recurrence score (RS) is a RT-PCR assay estimating risk of distant recurrence in estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2) breast cancer (BC). Studies validating RS are limited to women. Our objective was to assess RS distribution and factors associated with high-risk RS in male BC. METHODS: Using the Surveillance, Epidemiology, and End Results database, we identified men and women with ER+/HER2- BC from 2010 to 2013...
June 15, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29896282/aerosol-immunotherapy-with-or-without-cisplatin-for-metastatic-lung-cancer-non-small-cell-lung-cancer-disease-in-vivo-study-a-more-efficient-combination
#7
Konstantinos Sapalidis, Paul Zarogoulidis, Efstathios Pavlidis, Stella Laskou, Athanasios Katsaounis, Charilaos Koulouris, Dimitrios Giannakidis, Stylianos Mantalovas, Haidong Huang, Chong Bai, Yuting Wen, Li Wang, Chrysanthi Sardeli, Aikaterini Amaniti, Ilias Karapantzos, Chrysanthi Karapantzou, Wolfgang Hohenforst-Schmidt, Fotis Konstantinou, Isaak Kesisoglou, Naim Benhanseen
Lung cancer is the leading cause of cancer death after prostate cancer for males and breast cancer for females. There are novel therapies in the past five years such as; tyrosine kinase inhibitors and most recently in the last two years immunotherapy. Immunotherapy is currently being investigated if it can be administered alone or in combination. Previously we have investigated whether immunotherapy compounds can be produced as aerosols, and in the current study we investigated the safety and efficiency independently of the programmed death-ligand 1...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29891971/survival-comparisons-between-early-male-and-female-breast-cancer-patients
#8
Kang Wang, Qiu-Juan Wang, Yong-Fu Xiong, Yang Shi, Wen-Jing Yang, Xiang Zhang, Hong-Yuan Li
We aimed to compare the overall survival (OS) and standardized mortality rate (SMR) of the male breast cancer (MBC) with female breast cancer (FBC) after propensity score matching. Based on the Surveillance, Epidemiology, and End Results (SEER), the early breast cancer patients (T1-2 N0-2 M0 ) were extracted from 1998-2007. This study included 1,111 and 2,151 patients with early MBC and FBC, respectively, whose clinicopathological characteristics were well balanced. At a mean follow-up time of 97 months, 10-year OS rate was 58...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29891832/mediating-effects-of-patients-stigma-and-self-efficacy-on-relationships-between-doctors-empathy-abilities-and-patients-cellular-immunity-in-male-breast-cancer-patients
#9
Ningxi Yang, Yingnan Cao, Xiaoyan Li, Shiyue Li, Hong Yan, Qingshan Geng
BACKGROUND Doctors' empathy is closely related to patients' health. This study aimed to examine whether patients' stigma and self-efficacy play a mediating role in the relationship between doctors' empathy abilities and patients' cellular immunity in male patients with breast cancer. MATERIAL AND METHODS Doctors' empathy scores and patients' demographic data, disease condition, stigma, and self-efficacy were measured. Patient T cell subset was tested at admission and 3 months after the operation and was compared by paired t test...
June 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29891518/integrated-histogenetic-analysis-reveals-bap1-mutated-epithelioid-mesothelioma-in-a-patient-with-cancer-of-unknown-primary
#10
Tilmann Bochtler, Volker Endris, Anna Reiling, Jonas Leichsenring, Michal R Schweiger, Sebastian Klein, Fabian Stögbauer, Benjamin Goeppert, Peter Schirmacher, Alwin Krämer, Albrecht Stenzinger
This case report presents a male patient with epithelioid mesothelioma that was initially misdiagnosed as cancer of unknown primary (CUP) and correctly identified using molecular panel sequencing. The patient had a prior history of colon and breast cancer. To assess the enlarged mediastinal lymph nodes, retrosternal lymphadenectomy was performed in 2016. The lymph nodes were histologically deemed unrelated to the known breast cancer by the reference pathologist, thus leading to the diagnosis of a CUP syndrome...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29889616/physician-characteristics-and-decisions-regarding-cancer-screening-a-systematic-review
#11
Alfred I Neugut, Sarah A MacLean, Wei F Dai, Judith S Jacobson
The guidelines provided by experts regarding various cancer screening tests are not universally accepted by physicians or patients. This systematic review describes the literature regarding the associations of physician characteristics with the implementation of and referral of patients for selected cancer screening tests. In October 2016, the authors conducted a thorough search of articles found in 4 databases, using keywords describing physician characteristics and cancer screening. English-language articles reporting on patient surveys or records of patients' screening history, and surveys of physicians' practices or opinions, in the United States were included...
June 11, 2018: Population Health Management
https://www.readbyqxmd.com/read/29889460/evaluation-of-ischemic-stroke-patients-with-systemic-cancer
#12
Ufuk Emre, Taskin Gunes, Irem Pinar, Furuzan Kokturk, Esengul Liman, Orhan Yağiz
Background and purpose: In cancer patients, an ischemic stroke can be seen as both a direct effect of cancer and a complication of treatment. This condition can negatively affect the follow-up and treatment of these patients. For this research, we aimed to evaluate the clinical features, stroke types and etiological features of ischemic stroke patients with histories of cancer or found to have cancer during the aetiological investigation. Methods: We retrospectively evaluated 100 patients (57 males, 43 females) who were hospitalized with acute stroke and determined to have the presence of cancer or a cancer history during the aetiological investigation between 2011 and 2016...
May 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29886676/-incidence-trend-and-change-in-the-age-distribution-of-female-breast-cancer-in-cancer-registration-areas-of-china-from-2000-to-2014
#13
K X Sun, R S Zheng, X Y Gu, S W Zhang, H M Zeng, X N Zou, C F Xia, Z X Yang, H Li, W Q Chen, J He
Objective: To estimate the incidence trend and change in the age distribution of female breast cancer in cancer registry areas in China from 2000 to 2014. Methods: 22 cancer registries in China with continuous monitoring data from 2000 to 2014 were selected. All datasets were checked and evaluated based on data quality control criteria and were included in the analysis. The cancer registries covered 675 954 193 person-years, including 342 010 930 person-years of male and 333 943 263 person-years of female. Female breast cancer cases (International Classification of Diseases-10(th) Revision: C50) were extracted...
June 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29886235/implication-of-dietary-phthalates-in-breast-cancer-a-systematic-review
#14
Pietro Zuccarello, Gea Oliveri Conti, Federico Cavallaro, Chiara Copat, Antonio Cristaldi, Maria Fiore, Margherita Ferrante
Phthalates are endocrine-disrupting for their ability to change the normal function of human endocrine system. Their action on the reproductive system, both on male and female, is the most one investigated by international scientific community. The aim of this systematic review was to gather the available information regarding the role of phthalates on breast carcinogenesis focusing our research in their intake through the diet. Research was performed according the PRISMA methodology and 25 scientific articles published between 2000 and 2018 were selected...
June 7, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29881286/clinicopathologic-features-and-radiation-therapy-utilization-in-patients-with-male-breast-cancer-a-national-cancer-database-study
#15
REVIEW
Joshua Weir, Yan Daniel Zhao, Terence Herman, Özer Algan
Male breast cancer (MBC) accounts for approximately 1% of all breast cancers, limiting the data characterizing clinicopathologic features and treatment outcomes in patients with MBC. This paucity of data has led to most of our treatment guidance being extrapolated from patients with female breast cancer (FBC). From 1998 to 2012, data were captured using the National Cancer Database to identify patients with nonmetastatic MBC (n = 23 305) and FBC (n = 2 678 061). Tumor and clinicopathologic features were obtained and compared...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29876051/pure-low-grade-dcis-in-a-male-patient-a-case-report
#16
Araya Zaesim, Viva Nguyen, Charles S Scarborough
Breast cancer in males represents a small proportion of all cancers diagnosed. Pure ductal carcinoma in situ (DCIS), a low-grade form of breast cancer, is even more rare in male patients. We present a case of a 47-year-old male patient with a tender breast lump that was noted for 6 months. He was subsequently found to have a low grade, pure micropapillary and cribriform type DCIS with no evidence of invasive disease. Current literature does not provide distinct guidelines regarding management of male breast cancer, and it is currently managed in a similar fashion to female breast cancer...
May 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29875029/effect-of-daytime-blue-enriched-led-light-on-the-nighttime-circadian-melatonin-inhibition-of-hepatoma-7288ctc-warburg-effect-and-progression
#17
Robert T Dauchy, Melissa A Wren-Dail, Lynell M Dupepe, Steven M Hill, Shulin Xiang, Muralidharan Anbalagan, Victoria P Belancio, Erin M Dauchy, David E Blask
Liver cancer is the second leading cause of cancer death worldwide. Metabolic pathways within the liver and liver cancersare highly regulated by the central circadian clock in the suprachiasmatic nuclei (SCN). Daily light and dark cycles regulate the SCN-driven pineal production of the circadian anticancer hormone melatonin and temporally coordinate circadianrhythms of metabolism and physiology in mammals. In previous studies, we demonstrated that melatonin suppresses linoleicacid metabolism and the Warburg effect (aerobic glycolysis)in human breast cancer xenografts and that blue-enriched light(465-485 nm) from light-emitting diode lighting at daytime (bLAD) amplifies nighttime circadian melatonin levels in ratsby 7-fold over cool white fluorescent (CWF) lighting...
June 6, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29872347/lifetime-risks-loss-of-life-expectancy-and-health-care-expenditures-for-19-types-of-cancer-in-taiwan
#18
Tzu-Yi Wu, Chia-Hua Chung, Chia-Ni Lin, Jing-Shiang Hwang, Jung-Der Wang
Background: The mortality rates for different cancers are no longer an efficient tool for making national policy. The purpose of this study were to quantify the lifetime risks, life expectancies (LEs) after diagnosis, expected years of life lost (EYLL), and lifetime health care expenditures for 19 major cancers in Taiwan. Methods: A total of 831,314 patients with 19 pathologically proven cancers were abstracted from the Taiwan Cancer Registry from 1998 to 2012. They were linked to the National Mortality Registry (1998-2014) and National Health Insurance reimbursement database (1998-2013) for survival and health care costs...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29870283/use-of-inpatient-palliative-care-by-type-of-malignancy
#19
Jessica M Ruck, Joseph K Canner, Thomas J Smith, Fabian M Johnston
BACKGROUND: Although mounting evidence supports the use of palliative care (PC) to improve care experiences and quality of life for oncology patients, the frequency of and factors associated with PC use during oncology-related hospitalizations remain unknown. MATERIALS AND METHODS: Using the National Inpatient Sample dataset, hospitalizations during 2012-2014 for a primary diagnosis of cancer with high risk of in-hospital mortality were identified. PC use was identified using the V66...
June 5, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29868330/anterior-clinoid-metastasis-removed-extradurally-first-case-report
#20
Mirza Pojskić, Blazej Zbytek, Kenan I Arnautović
Background  We report a case of isolated metastasis on the anterior clinoid process (ACP) mimicking meningioma. Clinical Presentation  A 58-year-old male presented with headaches, right-sided visual disturbances, and blurred and double vision. The cause of double vision was partial weakness of the right III nerve, resulting from compression of the nerve by "hypertrophied" tumor-involved right anterior clinoid. Medical history revealed two primary malignant tumors-male breast cancer and prostate cancer (diagnosed 6 and 18 months prior, respectively)...
April 2018: Journal of Neurological Surgery Reports
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