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https://www.readbyqxmd.com/read/29454148/-68-ga-galmydar-biodistribution-and-radiation-dosimetry-studies-in-rodents
#1
Jothilingam Sivapackiam, Richard Laforest, Vijay Sharma
INTRODUCTION: 68 Ga-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells. 68 Ga-Galmydar excretes from blood pool quickly, and shows stable retention within rat myocardium in vivo for extended periods, therefore, the agent shows potential to enable myocardial perfusion imaging...
December 1, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29446744/delivery-of-peptidic-gonadotropin-releasing-hormone-antagonists
#2
Rawda Yaseen AlSheyyab, Bashar Mohammad Al-Taani, Rana Mohammad Obeidat, Motasem Mohammad Alsmadi, Rafeef Khalid Masaedeh, Raghda Nasry Sabat
GnRH antagonists have several clinical applications in prostate cancer, regulation of ovulation induction in females, breast cancer, male contraception and others. Antagonists differ from natural GnRH decapeptide in having five or more amino acid substitutions. Whereas most of antagonists are available as subcutaneous (SC) formula for injection, some are formulated as a depot formulation for sustained release (e.g. Cetrarelix, Degarelix). Systemic delivery of cetrorelix acetate by intratracheal route can be achieved using dry powder for inhalation of adhesive mixture when the powder deposition reaches stage four...
February 14, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29433453/male-brca-mutation-carriers-clinical-characteristics-and-cancer-spectrum
#3
Mohammed Ibrahim, Siddhartha Yadav, Foluso Ogunleye, Dana Zakalik
BACKGROUND: Mutations in BRCA1 and BRCA2 (BRCA1/2) genes are associated with an increased risk of breast and ovarian cancers in women. The cancer characteristics of men with BRCA1/2 mutations are less well studied. This study describes the unique cancer characteristics of male BRCA1/2 mutation carriers at our institution. METHODS: We performed a retrospective chart review on male patients who were seen between January 2004 and December 2014 and tested positive for a BRCA1/2 mutation...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29427783/gout-drugs-use-and-risk-of-cancer-a-case-control-study
#4
Hsuan-Chia Yang, Phung Anh Alex Nguyen, Md Mohaimenul Islam, Chih-Wei Huang, Tahmina Nasrin Poly, Usman Iqbal, Yu-Chuan Jack Li
OBJECTIVE: Firm conclusion about whether short and long-term gout medications use has an impact on cancer risk remain inconclusive. The aim of this study was to investigate the association between gout drugs use and risk of cancer. METHODS: We conducted a retrospective longitudinal population-based case-control study in Taiwan. Cases were identified all patients who were aged 20 years or above, and had a first time diagnosis of cancers for the period between 2001 and 2011...
February 7, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29426306/characteristics-of-people-living-in-italy-after-a-cancer-diagnosis-in-2010-and-projections-to-2020
#5
Stefano Guzzinati, Saverio Virdone, Roberta De Angelis, Chiara Panato, Carlotta Buzzoni, Riccardo Capocaccia, Silvia Francisci, Anna Gigli, Manuel Zorzi, Giovanna Tagliabue, Diego Serraino, Fabio Falcini, Claudia Casella, Antonio Giampiero Russo, Fabrizio Stracci, Bianca Caruso, Maria Michiara, Anna Luisa Caiazzo, Marine Castaing, Stefano Ferretti, Lucia Mangone, Giuseppa Rudisi, Flavio Sensi, Guido Mazzoleni, Fabio Pannozzo, Rosario Tumino, Mario Fusco, Paolo Ricci, Gemma Gola, Adriano Giacomin, Francesco Tisano, Giuseppa Candela, Anna Clara Fanetti, Filomena Pala, Antonella Sutera Sardo, Massimo Rugge, Laura Botta, Luigino Dal Maso
BACKGROUND: Estimates of cancer prevalence are widely based on limited duration, often including patients living after a cancer diagnosis made in the previous 5 years and less frequently on complete prevalence (i.e., including all patients regardless of the time elapsed since diagnosis). This study aims to provide estimates of complete cancer prevalence in Italy by sex, age, and time since diagnosis for all cancers combined, and for selected cancer types. Projections were made up to 2020, overall and by time since diagnosis...
February 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29414637/first-data-from-a-population-based-cancer-registry-in-ethiopia
#6
Genebo Timotewos, Asmare Solomon, Assefa Mathewos, Adamu Addissie, Solomon Bogale, Tigeneh Wondemagegnehu, Abraha Aynalem, Bekele Ayalnesh, Hailemariam Dagnechew, Wondatir Bireda, Eric Sven Kroeber, Rafael Mikolajczyk, Freddie Bray, Ahmedin Jemal, Eva Johanna Kantelhardt
BACKGROUND: The Addis Ababa City Cancer Registry, established in September 2011, is the only population-based cancer registry in Ethiopia, covering a catchment population of just over three million habitants. Herein, we report incidence data based on the first two years of registration, 2012-2013. METHODS: Newly-diagnosed cancer cases in the capital city were actively collected from 22 hospitals, clinics, and diagnostic facilities. RESULTS: During 2012-2013, a total of 4139 newly diagnosed cases were recorded, with the majority (67%) occurring in females...
February 1, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29409476/germline-brca1-brca2-mutations-among-high-risk-breast-cancer-patients-in-jordan
#7
Hikmat Abdel-Razeq, Amal Al-Omari, Farah Zahran, Banu Arun
BACKGROUND: Breast cancer is the most common malignancy and the leading cause of cancer-related deaths among Jordanian women. With a median age of 50 years at diagnosis, a higher prevalence of hereditary breast cancer may be expected. The objective of this pilot study is to evaluate, for the first time, the contribution of germline mutations in BRCA1/2 to breast cancer among Jordanian patients. METHODS: Jordanian breast cancer women with a selected high risk profile were invited to participate...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29405242/occupational-exposure-to-organic-solvents-and-risk-of-male-breast-cancer-a-european-multicenter-case-control-study
#8
Nasser Laouali, Corinne Pilorget, Diane Cyr, Monica Neri, Linda Kaerlev, Svend Sabroe, Giuseppe Gorini, Lorenzo Richiardi, Maria Morales-Suárez-Varela, Agustin Llopis-Gonzalez, Wolfgang Ahrens, Karl-Heinz Jöckel, Noemia Afonso, Mikael Eriksson, Eriksson Merletti, Jørn Olsen, Elsebeth Lynge, Pascal Guénel
Objectives The etiology of male breast cancer (MBC) is largely unknown but a causal role of exposure to organic solvents has been suggested. Previous studies on occupational risk factors of breast cancer were often restricted to women who are frequently exposed to lower levels and at a lower frequency than men. We investigated the association between MBC and occupational exposure to petroleum and oxygenated and chlorinated solvents in a multicenter case-control study of rare cancers in Europe. Methods The study included 104 MBC cases and 1901 controls...
February 6, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29404823/-second-class-status-insight-into-communication-patterns-and-common-concerns-among-men-with-hereditary-breast-and-ovarian-cancer-syndrome
#9
Alexandra Suttman, Robert Pilarski, Doreen M Agnese, Leigha Senter
Hereditary breast and ovarian cancer syndrome (HBOC) is a cancer predisposition syndrome that affects both men and women, with more significant cancer risk elevations in women. Dissemination patterns regarding familial genetic risk information among females with HBOC are fairly well defined, but knowledge about how males share this information is limited. We interviewed 21 people primarily Ashkenazi Jewish men who were accrued via listserv email through Facing Our Risk of Cancer Empowered (FORCE). Interviews focused on family cancer history, experiences with cancer and genetic testing, motivations to pursue genetic testing and subsequently disclose genetic test results, information-sharing patterns, health care provider response, and participants' emotional support systems...
February 5, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29404286/male-breast-cancer-a-retrospective-review-of-clinical-profile-from-a-tertiary-cancer-care-center-of-india
#10
Dharma Ram, Suhas K Rajappa, Veda P Selvakumar, Himanshu Shukla, Ashish Goel, Rajeev Kumar, Kapil Kumar
Aim: Present study was done with an aim to analyse the clinicopathological and survival characteristics of male breast cancer patients. Methods: We did a retrospective review of our database and analysed total 27 patients who presented to breast oncology unit of Rajiv Gandhi cancer centre and research institute from January 2010 to April 2016. Results: Most common stage at presentation in our study was in stage II. The median follow up was 32...
October 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29400121/-guys-don-t-have-breasts-the-lived-experience-of-men-who-have-brca-gene-mutations-and-are-at-risk-for-male-breast-cancer
#11
Michelle Skop, Justin Lorentz, Mobin Jassi, Danny Vesprini, Gillian Einstein
Men with BRCA1 or BRCA2 gene mutations are at increased risk of developing breast cancer and may have an indication for breast cancer screening using mammography. Since breast cancer is often viewed as a woman's disease, visibilizing and understanding men's experience of having a BRCA mutation and specifically, of screening for breast cancer through mammography, were the objectives of this research study. The theoretical framework of interpretive phenomenology guided the process of data collection, coding, and analysis...
February 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29399850/three-dimensional-shear-wave-elastography-of-skeletal-muscle-preliminary-study
#12
Li Yin, Ruigang Lu, Wen Cao, Lingling Zhang, Wenjing Li, Hong Sun, Ruijun Guo
OBJECTIVES: Two-dimensional (2D) shear wave elastography (SWE) can measure the elasticity of skeletal muscle, tendons, and ligaments. Three-dimensional (3D) SWE has been used to detect breast cancer but has not been applied to the musculoskeletal system. This study aimed to investigate whether 3D SWE could be used in skeletal muscles in vivo. METHODS: The study enrolled 20 healthy volunteers at Beijing Chaoyang Hospital from August to October 2016. Two-dimensional and 3D SWE scans were used to measure the Young modulus of the flexor carpi radialis in the relaxed state...
February 5, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29396493/characterizing-steroid-hormone-receptor-chromatin-binding-landscapes-in-male-and-female-breast-cancer
#13
Tesa M Severson, Yongsoo Kim, Stacey E P Joosten, Karianne Schuurman, Petra van der Groep, Cathy B Moelans, Natalie D Ter Hoeve, Quirine F Manson, John W Martens, Carolien H M van Deurzen, Ellis Barbe, Ingrid Hedenfalk, Peter Bult, Vincent T H B M Smit, Sabine C Linn, Paul J van Diest, Lodewyk Wessels, Wilbert Zwart
Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment is also noted. The pan-hormonal action of steroid hormonal receptors, including estrogen receptor alpha (ERα), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) in this understudied tumor type remains wholly unexamined. This study reveals genomic cross-talk of steroid hormone receptor action and interplay in human tumors, here in the context of MBC, in relation to the female disease and patient outcome...
February 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29395956/furan-and-p-xylene-as-candidate-biomarkers-for-prostate-cancer
#14
Antonio Jiménez-Pacheco, María Salinero-Bachiller, María C Iribar, Alfonso López-Luque, José L Miján-Ortiz, Jose M Peinado
BACKGROUND: Prostate cancer (PCa) is the most frequently diagnosed noncutaneous malignant tumor among males in the Western world. Prostate-specific antigen has been considered the most important biomarker for PCa detection; however, it lacks specificity, leading to the search for alternative biomarkers. Volatile organic compounds (VOCs) are released during cell metabolism and can be found in exhaled breath, urine, and other fluids. VOCs have been used in the diagnosis of lung, breast, ovarian, and colorectal cancers, among others...
January 21, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29394792/-a-case-of-noninvasive-ductal-carcinoma-of-the-breast-in-a-male
#15
Yamato Yamashita, Toshiyuki Ishiba, Goshi Oda, Tsuyoshi Nakagawa, Tomoki Aburatani, Taiichi Ogo, Yutaka Nakashima, Hironobu Baba, Naoaki Hoshino, Yoshinobu Nishioka, Tatsuyuki Kawano, Takashi Itoh, Susumu Kirimura, Hirotoshi Kobayashi
Breast cancer in male is rare, accounting for 1%of all breast cancers.Among male breast cancers, noninvasive carcinoma is extremely rare.We experienced a case of noninvasive carcinoma of the breast in a male.A 72-year-old male was referred to our hospital with a chief complaint of the tumor and blood secretion from the left nipple.Mammography revealed a highdensity mass.Ultrasound examination revealed low echoic mass at the E area, and it measured 1.5 cm.Core needle biopsy failed to provide a definitive diagnosis, and we performed an excisional biopsy of the tumor...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390502/male-occult-breast-cancer-with-axillary-lymph-node-metastasis-as-the-first-manifestation-a-case-report-and-literature-review
#16
Ruixin Xu, Jianbin Li, Yingjie Zhang, Hongbiao Jing, Youzhe Zhu
RATIONALE: Occult breast cancer (OBC) is extremely rare in males with neither symptoms in the breast nor abnormalities upon imaging examination. PATIENT CONCERNS: This current case report presents a young male patient who was diagnosed with male OBC first manifesting as axillary lymph node metastasis. The physical and imaging examination showed no primary lesions in either breasts or in other organs. DIAGNOSES: The pathological results revealed infiltrating ductal carcinoma in the axillary lymph nodes...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382506/klinefelter-syndrome-more-than-hypogonadism
#17
REVIEW
George A Kanakis, Eberhard Nieschlag
Klinefelter syndrome (KS) is the most frequent chromosome disorder in males (1:650 newborn males), defined by 47,XXY karyotype. The classical phenotype is that of a tall male with relatively long legs, small, firm testes and gynecomastia. Azoospermia and infertility are almost inevitably present, but may be overcome by TESE and ICSI. Nevertheless, a broad spectrum of phenotypes has been described and >70% of the actually existing KS men may remain undiagnosed throughout their lifespan. Accordingly, hypogonadism is usually not evident until early adulthood and progresses with ageing...
January 27, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29380845/occurrence-of-malnutrition-and-associated-factors-in-community-dwelling-older-adults-those-with-a-recent-diagnosis-of-cancer-are-at-higher-risk
#18
C Van Den Broeke, T De Burghgraeve, M Ummels, N Gescher, L Deckx, V Tjan-Heijnen, F Buntinx, M van den Akker
OBJECTIVES: In older adults, nutritional health is essential for good quality of life and living independently at home. Especially in cancer patients, malnutrition is common and known to complicate treatment. This study aims to evaluate the nutritional status and its associated factors in community-dwelling older adults with and without cancer. DESIGN: This is an observational study. SETTING: This study focuses on older community-dwelling people...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29376219/selenium-for-preventing-cancer
#19
REVIEW
Marco Vinceti, Tommaso Filippini, Cinzia Del Giovane, Gabriele Dennert, Marcel Zwahlen, Maree Brinkman, Maurice Pa Zeegers, Markus Horneber, Roberto D'Amico, Catherine M Crespi
BACKGROUND: This review is the third update of the Cochrane review "Selenium for preventing cancer". Selenium is a naturally occurring element with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancer. OBJECTIVES: To gather and present evidence needed to address two research questions:1. What is the aetiological relationship between selenium exposure and cancer risk in humans?2...
January 29, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29374892/-trend-of-cancer-mortality-in-hebei-province-1973-2013
#20
D Liang, D J Li, J Shi, Y C Zhang, T T Guo, Y T He
Objective: To analyze the data of malignant tumor mortality and change in disease burden in Hebei province from 1973 to 2013. Methods: Cancer mortality rate, age-standardized mortality rate and the years of life lost due to premature mortality (YLLs) were calculated by using the data from three rounds of all death causes survey and database of cancer registry in Hebei during 1973-2013. Results: From 1973 to 2013, a linear upward of malignant tumor mortality was observed, with a 51.57% increase. The mortality rate during 1973-1975 was 98...
January 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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