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https://www.readbyqxmd.com/read/28345847/five-year-survival-is-not-a-useful-measure-for-cancer-control-in-the-population-an-analysis-based-on-uk-data
#1
Si Qi Li, Xiong Fei Pan, Michael Saheb Kashaf, Qing Ping Xue, Hui Jing Luo, Yan Yan Wang, Ying Wen, Chun Xia Yang
Background: Five-year survival is an important metric for progress in cancer control broadly used both in the cancer literature and by the public. In order to assess its validity and relation to other common metrics, we analyzed the relationship between 5-year survival, incidence and mortality using publicly available cancer registry data from England and Wales. Methods: Five-year survival, incidence and mortality data were obtained from the online database of a registered charity, Cancer Research UK. We extracted sex-specific age-standardized mortality, incidence, and 5-year survivalfor16 types of cancer over the period from 1976 to 1995...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28338430/trends-of-second-primary-malignancy-in-patients-with-thyroid-cancer-a-population-based-cohort-study-in-israel
#2
Elena Izkhakov, Micha Barchana, Irena Liphshiz, Barbara Silverman, Naftali Stern, Lital Keinan-Boker
BACKGROUND: Thyroid cancer (TC) is the most common endocrine malignancy. TC patients have a good prognosis and a low disease-related mortality rate. Since the patients are often young, they may be at a higher risk for a second primary malignancy (SPM). We sought to determine the incidence, risk and types of SPM between 1980-2011, and to assess SPM trends over time among Israeli TC patients. METHODS: Data were derived from the Israel National Cancer Registry. Primary TC patients diagnosed during 1980-2009 were followed-up for SPM incidence until December 31, 2011...
March 24, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28334947/protocadherin-19-pcdh19-interacts-with-paraspeckle-protein-nono-to-co-regulate-gene-expression-with-estrogen-receptor-alpha-er%C3%AE
#3
Duyen H Pham, Chuan Tan, Claire C Homan, Kristy Kolc, Mark Corbett, Dale McAninch, Archa Fox, Paul Thomas, Raman Kumar, Jozef Gecz
De novo and inherited mutations of X-chromosome cell adhesion molecule protocadherin 19 (PCDH19) cause frequent, highly variable epilepsy, autism, cognitive decline and behavioural problems syndrome. Intriguingly, hemizygous null males are not affected while heterozygous females are, contradicting established X-chromosome inheritance. The disease mechanism is not known. Cellular mosaicism is the likely driver. We have identified p54nrb/NONO, a multifunctional nuclear paraspeckle protein with known roles in nuclear hormone receptor gene regulation, as a PCDH19 protein interacting partner...
March 17, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28334234/breast-cancer-risk-associated-variants-at-6q25-1-influence-risk-of-hepatocellular-carcinoma-in-a-chinese-population
#4
Jiaoyuan Li, Ying Wang, Ying Zhu, Yajie Gong, Yang Yang, Jianbo Tian, Yi Zhang, Danyi Zou, Xiating Peng, Juntao Ke, Jing Gong, Rong Zhong, Jiang Chang
The gender disparity observed in the incidence of hepatocellular carcinoma (HCC) suggests an important role of estrogens in HCC pathogenesis. In this study, we conducted a case-control study to investigate whether breast cancer risk-associated single nucleotide polymorphisms (SNPs) located at estrogens loci identified by genome-wide association studies (GWASs) also predispose to HCC in a Chinese population. Three candidate SNPs at 6q25.1 were genotyped in 2,025 HCC cases and 2,032 healthy controls. Differential expression analyses and expression quantitative trait loci (eQTL) analyses were conducted to further explore the role of significant SNPs and genes they reside in...
March 3, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28332165/low-microchimeric-cell-density-in-tumors-suggests-alternative-antineoplastic-mechanism
#5
Timothy W Jolis, Brenna M Brucker, Christoph Schorl, James N Butera, Peter J Quesenberry
Microchimerism has generally been shown to protect against cancer (Gilmore et al. in Exp Hematol 36(9):1073-1077, 2008). The mechanism of how this occurs is an area of intense study, as it may lead to new cancer treatments. The leading theory is that microchimeric cells perform immune surveillance by directly fighting cancerous cells and that they also act as stem cells, repairing damaged tissue (Khosrotehrani et al. in JAMA 292:75-80, 2004). However, there is conflicting evidence to support this theory. Several small studies have found few microchimeric cells in tumor tissue (Gadi in Breast Cancer Res Treat 121(1):241-244, 2010; Cirello et al...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28331756/the-management-and-outcomes-of-male-breast-cancer
#6
Ömer Uslukaya, Metehan Gümüş, Hatice Gümüş, Zübeyir Bozdağ, Ahmet Türkoğlu
OBJECTIVE: Due to a lack of sufficient data, the treatment protocols for male breast cancer are usually the same as those used for female breast cancer. The aim of the current study was to present our clinical experience with male breast cancer. MATERIALS AND METHODS: The records of 37 patients who were treated for male breast cancer in our hospital between 2004 and 2014 were reviewed retrospectively. The data of patients were recorded and analyzed. RESULTS: The mean age of the patients was 63...
October 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28327158/the-clinicopathological-parameters-and-prognostic-significance-of-her2-expression-in-gastric-cancer-patients-a-meta-analysis-of-literature
#7
REVIEW
Yu-Ying Lei, Jin-Yu Huang, Qiong-Rui Zhao, Nan Jiang, Hui-Mian Xu, Zhen-Ning Wang, Hai-Qing Li, Shi-Bo Zhang, Zhe Sun
BACKGROUND: Human epidermal growth factor receptor-2 (HER2) is regarded as an important and promising target in the treatment of HER2-positive breast cancers. However, the correlation of clinicopathological characteristics and prognostic significance of HER2 overexpression in gastric cancer patients remains unclear. Our aim was to clarify this issue. METHODS: Embase, PubMed, and the Cochrane Library were searched for relevant articles published up to May 2016. Outcomes of interest contained sex, age, tumor size, tumor site, tumor node metastasis (TNM) stage, distant metastasis, lymph node metastasis, Lauren's classification, differentiation grade, lymphovascular invasion, neural invasion, and multivariate analysis data for overall survival...
March 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28301662/brain-metastases-in-newly-diagnosed-breast-cancer-a-population-based-study
#8
Allison M Martin, Daniel N Cagney, Paul J Catalano, Laura E Warren, Jennifer R Bellon, Rinaa S Punglia, Elizabeth B Claus, Eudocia Q Lee, Patrick Y Wen, Daphne A Haas-Kogan, Brian M Alexander, Nancy U Lin, Ayal A Aizer
Importance: Population-based estimates of the incidence and prognosis of brain metastases at diagnosis of breast cancer are lacking. Objective: To characterize the incidence proportions and median survivals of patients with breast cancer and brain metastases at the time of cancer diagnosis. Design, Setting, and Participants: Patients with breast cancer and brain metastases at the time of diagnosis were identified using the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute...
March 16, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28300967/burden-of-cancer-mortality-and-differences-attributable-to-demographic-aging-and-risk-factors-in-argentina-1986-2011
#9
Sonia Alejandra Pou, Natalia Tumas, Julia Becaria Coquet, Camila Niclis, María Dolores Román, María Del Pilar Díaz
The world faces an aging population that implies a large number of people affected with chronic diseases. Argentina has reached an advanced stage of demographic transition and presents a comparatively high rate of cancer mortality within Latin America. The objectives of this study were to examine cancer mortality trends in the province of Córdoba, Argentina, between 1986 and 2011, and to analyze the differences attributable to risk variations and demographic changes. Longitudinal series of age-standardized mortality rates for overall, breast and prostate cancers were modeled by Joinpoint regression to estimate the annual percent change...
March 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28300426/soluplus%C3%A2-tpgs-mixed-micelles-for-dioscin-delivery-in-cancer-therapy
#10
Jing Zhao, Youwei Xv, Changyuan Wang, Yanfang Ding, Manyu Chen, Yifei Wang, Jinyong Peng, Lei Li, Li Lv
BACKGROUND: Dioscin has shown cytotoxicity against cancer cells, but its poor solubility and stability have limited its clinical application. In this study, we designed mixed micelles composed of TPGS and Soluplus(®) copolymers entrapping the poorly soluble anticancer drug dioscin. METHOD: In order to improve the aqueous solubility and bioactivity of dioscin, TPGS/Soluplus® mixed micelles with an optimal ratio were prepared using a thin-film hydration method, and their physicochemical properties were characterized...
March 16, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28292651/human-exposure-to-endocrine-disrupting-chemicals-effects-on-the-male-and-female-reproductive-systems
#11
REVIEW
Stavros Sifakis, Vasilis P Androutsopoulos, Aristeidis M Tsatsakis, Demetrios A Spandidos
Endocrine disrupting chemicals (EDCs) comprise a group of chemical compounds that have been examined extensively due to the potential harmful effects in the health of human populations. During the past decades, particular focus has been given to the harmful effects of EDCs to the reproductive system. The estimation of human exposure to EDCs can be broadly categorized into occupational and environmental exposure, and has been a major challenge due to the structural diversity of the chemicals that are derived by many different sources at doses below the limit of detection used by conventional methodologies...
March 6, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28292559/pathological-characterisation-of-male-breast-cancer-results-of-the-eortc-10085-tbcrc-big-nabcg-international-male-breast-cancer-program
#12
Marijn A Vermeulen, Leen Slaets, Fatima Cardoso, Sharon H Giordano, Konstantinos Tryfonidis, Paul J van Diest, Nizet H Dijkstra, Carolien P Schröder, Christi J van Asperen, Barbro Linderholm, Kim Benstead, Renee Foekens, John W M Martens, John M S Bartlett, Carolien H M van Deurzen
AIM: Several prognostic histological features have been established in female breast cancer (BC), but it is unknown whether these can be extrapolated to male BC patients. The aim of this study was to evaluate the prognostic value of several histological features in a large series of male BC. METHODS: Central pathology review was performed for 1483 male BCs collected through part 1 of the European Organisation for Research and Treatment of Cancer (EORTC) International Male BC Program...
March 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28290337/perceptions-of-australian-clients-towards-male-radiographers-working-in-breast-imaging-quantitative-results-from-a-pilot-study
#13
H M Warren-Forward, B Mackie, M Alchin, T Mooney, P Fitzpatrick
AIM: Breast cancer is the second most common cause of cancer-related death in Australian women, therefore early breast cancer detection is essential. Female radiographers currently conduct breast screening in Australia; however there is a projected shortage. With many women already feeling apprehensive about attending a breast examination, possible proposals to fill this shortage must be carefully considered. Training male radiographers is one proposal however, this raises some gender concerns...
February 2017: Radiography
https://www.readbyqxmd.com/read/28277339/clinical-dilemmas-in-the-management-of-transgender-men
#14
Michael S Irwig
PURPOSE OF REVIEW: To explore the medical and surgical clinical dilemmas in the management of trans (transgender) men, a growing population receiving more attention than in the past. RECENT FINDINGS: Testosterone therapy is commonly prescribed to trans men for masculinization. Nonetheless, the optimal formulations and doses of testosterone therapy for trans men have not been well established. Testosterone therapy has been associated with increased levels of hemoglobin and triglycerides, as well as diabetes...
March 8, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28274189/intracerebroventricular-administration-of-the-1%C3%A2-6-%C3%AE-d-glucan-lasiodiplodan-in-male-rats-prevents-d-penicillamine-induced-behavioral-alterations-and-lipoperoxidation-in-the-cortex
#15
Carlos Ricardo Maneck Malfatti, Fabio Seidel Dos Santos, Jéssica Wouk, Luiz Augusto da Silva, Renan Garcia Michel, André Luiz Snak, Tiago Czervinski, Mário A Alves da Cunha, Aneli M Barbosa, Robert F H Dekker
CONTEXT: Lasiodiplodan, an exocellular (1→6)-β-d-glucan of molecular weight >1.4 × 10(6) Da produced by MMPI strain of Lasiodiplodia theobromae (Pat.) Griffon & Maubl. (Brotyosphaeriaceae) is known to exhibit anti-proliferative activity on breast cancer cells (MCF-7), anticoagulant activity when sulfonylated, and reduction in transaminase activity when administered in rats. OBJECTIVE: The effect of intracerebroventricular (I.C.V) injection of lasiodiplodan on neurotoxicity and behavioural changes induced by d-penicillamine was investigated...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28272287/risk-factors-and-outcomes-of-de-novo-cancers-excluding-nonmelanoma-skin-cancer-after-liver-transplantation-for-primary-sclerosing-cholangitis
#16
Mohamad A Mouchli, Siddharth Singh, Edward V Loftus, Lisa Boardman, Jayant Talwalkar, Charles B Rosen, Julie K Heimbach, Russell H Wiesner, Bashar Hasan, John J Poterucha, Kymberly D Watt
BACKGROUND: Patients with primary sclerosing cholangitis (PSC) may be at higher of risk of malignancy after liver transplantation (LT) compared to other LT recipients. We aimed to determine the cumulative incidence of/risk factors for and long-term cancer-related mortality in patients with PSC after LT. METHODS: All adult patients who underwent LT for PSC without cholangiocarcinoma from 1984-2012, with follow-up through June 2015. We estimated cumulative incidence, risk factors and mortality from de novo malignancies after LT RESULTS: 293 patients were identified (mean age, 47±12 years; 63...
March 8, 2017: Transplantation
https://www.readbyqxmd.com/read/28268206/profile-of-cancer-in-the-eastern-mediterranean-region-the-need-for-action
#17
Ivana Kulhánová, Freddie Bray, Ibtihal Fadhil, Ali Saeed Al-Zahrani, Amani El-Basmy, Wagida A Anwar, Amal Al-Omari, Ali Shamseddine, Ariana Znaor, Isabelle Soerjomataram
BACKGROUND: Many countries in the Eastern Mediterranean region (EMR) are undergoing marked demographic and socioeconomic transitions that are increasing the cancer burden in region. We sought to examine the national cancer incidence and mortality profiles as a support to regional cancer control planning in the EMR. METHODS: GLOBOCAN 2012 data were used to estimate cancer incidence and mortality by country, cancer type, sex and age in 22 EMR countries. We calculated age-standardized incidence and mortality rates (per 100,000) using direct method of standardization...
March 4, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28262108/male-breast-cancer-mimicking-melanoma
#18
T Kueder Pajares, A J García Malinis, P Manchado López
No abstract text is available yet for this article.
March 2, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28257827/recent-advances-on-bisphenol-a-and-endocrine-disruptor-effects-on-human-prostate-cancer
#19
Marzia Di Donato, Gustavo Cernera, Pia Giovannelli, Giovanni Galasso, Antonio Bilancio, Antimo Migliaccio, Gabriella Castoria
Endocrine disrupting chemicals (EDCs) are man-made substances widespread in the environment that include, among many others, bisphenol A (BPA), organochlorinated pesticides and hormone derivatives detectable in meat from animals raised in concentrated animal feeding operations. Increasing evidence indicates that EDCs have a negative impact on human health as well as on male and female fertility. They may also be associated with some endocrine diseases and increased incidence of breast and prostate cancer. This review aims to summarize available data on the (potential) impact of some common EDCs, focusing particularly on BPA, prostate cancer and their mechanisms of action...
February 28, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28248528/women-s-health-care-the-experiences-and-behaviors-of-rural-and-urban-lesbians-in-the-usa
#20
K Nikki Barefoot, Jacob C Warren, K Bryant Smalley
INTRODUCTION: Previous research has consistently demonstrated that, in comparison to their cisgender heterosexual counterparts, lesbians face a multitude of women's healthcare-related disparities. However, very little research has been conducted that takes an intersectionality approach to examining the potential influences of rural-urban location on the health-related needs and experiences of lesbians. The purpose of this study was to quantitatively compare rural and urban lesbians' access to women's health care, experiences with women's healthcare providers (WHCPs), and preventive behavior using a large, diverse sample of lesbians from across the USA...
January 2017: Rural and Remote Health
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