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https://www.readbyqxmd.com/read/28524897/transgender-patient-screening-breast-cancer-risk-assessment-and-screening-recommendations%C3%A2
#1
Deirdre Kiely
BACKGROUND: When a discrepancy exists between an individual's biologic sex and the deeply felt sense of being male or female, a transgender orientation may result. 
. OBJECTIVES: The purpose of this article is to summarize breast cancer risk assessment and screening recommendations for transgender individuals. 
. METHODS: A review of the literature was done to determine if evidence-based screening guidelines exist for transgender individuals and how they can be applied to clinical practice...
June 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28521182/should-nonsmokers-be-excluded-from-early-lung-cancer-screening-with-low-dose-spiral-computed-tomography-community-based-practice-in-shanghai
#2
Xiaoyang Luo, Shanbo Zheng, Quan Liu, Shengping Wang, Yuan Li, Lei Shen, Guodong Li, Wentao Li, Yanping Zhao, Huilin Xu, Jing Wang, Xiaohua Liu, Yunjian Pan, Hong Hu, Yihua Sun, Haiyan Yang, Su Xu, Haiquan Chen
OBJECTIVE: We investigated the efficacy of early lung cancer screening with low-dose spiral computed tomography(LDCT) in both smokers and nonsmokers based on the current situation of community health service, with integration of superior resources of medical institutions at all levels in Shanghai. METHODS: From August 2013 to August 2014, we screened 11,332 (male 7144; female 4188) high-risk individuals in selected communities of Minhang, Shanghai City, for early diagnosis of lung cancer with LDCT combined with multidisciplinary comprehensive treatment pattern including minimally invasive surgery, exploring the medical service network covering prevention, diagnosis, treatment, rehabilitation, and follow-up...
May 15, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28511393/utility-of-tru-cut-biopsy-of-breast-lesions-an-experience-in-a-regional-cancer-center-of-a-developing-country
#3
Sagarika Samantaray, Niharika Panda, Kusumabati Besra, Lucy Pattanayak, Subrat Samantara, Sashibhusan Dash
INTRODUCTION: Tru-cut Needle Biopsy (TCB) is an integral part of triple assessment of breast cancer, which includes clinical assessment, mammography and TCB or Core Needle Biopsy (CNB). The technique is reliable, simple, and reproducible, and inexpensive, which can be adapted even for low-income group of patients and in developing countries. AIM: This study was done to establish the efficacy of TCB of palpable breast lesions in a developing country where mammography is not possible in all cases...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511290/first-use-of-antidepressant-medication-in-male-partners-of-women-with-breast-cancer-in-denmark-1998-2011
#4
Pernille F Cromhout, Kristine M Latocha, Maja H Olsen, Nis P Suppli, Jane Christensen, Christoffer Johansen, Susanne O Dalton
BACKGROUND: A diagnosis of breast cancer disrupts the life of the patient, but also the partner may experience adverse psychological effects. We examined partners' risk for first use of antidepressant medication, as a proxy for pharmacologically treated depression. METHODS: By linkage of national registers, we identified 1,420,592 depression-free men living with a cancer-free female partner in 1998-2011. During follow-up, breast cancer was diagnosed in female partners of 26,256 men...
May 16, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28511243/-emotional-arousal-voice-stress-and-posttraumatic-growth-as-well-as-relationship-satisfaction-of-partners-of-women-with-breast-cancer-in-the-context-of-social-support
#5
Tanja Zimmermann, Jan H Krüger, Sarah Weusthoff
Introduction Breast cancer is associated with significant psychosocial strains for both patients and partners. Constructive social support and positive communication behavior have been shown to be protective against the burdens associated with breast cancer. Individual levels of emotional arousal during social support interactions with one's spouse are an important aspect of couples' support behaviors and can be assessed via vocal fundamental frequency (f0). Methods N=44 couples had standardized seven-minute long interactions asking the male partner to describe his thoughts and feelings with regard to their wives' breast cancer...
May 16, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28510469/outer-dense-fiber-proteins-bridging-between-male-infertility-and-cancer
#6
Faezeh Azizi, Soudeh Ghafouri-Fard
BACKGROUND: The similarities between gametogenic and carcinogenesis processes have been noted for more than decades. Among prominent similarities between these two processes is expression of a group of antigens, namely cancer-testis antigens in both the testes and various cancer tissues. Outer dense fiber (ODF) proteins are testis-specific proteins localized to sperm tails and involved in sperm motility. METHODS: We performed a computerized search of the MEDLINE/PUBMED databases with keywords "outer dense fiber, ODF, cancer, testis, gametogenesis and infertility"...
May 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28509937/next-generation-sequencing-is-informing-phenotype-a-tp53-example
#7
R O'Shea, R Clarke, E Berkley, C Giffney, M Farrell, E O'Donovan, D J Gallagher
The increased availability of next generation sequencing (NGS) and multi gene panel testing has resulted in more frequent TP53 testing of families that do not meet classic testing criteria. We investigated testing criteria, family history and result outcome in a cohort of Irish probands undergoing TP53 full sequencing. All TP53 test requests processed through the national genetic testing laboratory between 2012 and 2014 were retrospectively reviewed. Personal and family cancer histories were collected, including tumour type and age at diagnosis, from two adult cancer genetic services in Ireland...
May 16, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28508827/multiple-primary-malignant-neoplasms-a-10-year-experience-at-a-single-institution-from-turkey
#8
Durmus Etiz, Evrim Metcalfe, Melek Akcay
PURPOSE: The development of improved diagnostic techniques, increased survival, and life expectancy of cancer patients have all contributed to the higher frequency of multiple primary malignant neoplasms (MPMN). MPMN can be divided into two main categories: Synchronous MPMN (sMPMN) and metachronous MPMN (mMPMN). MATERIALS AND METHODS: 122 patients with MPMN analyzed retrospectively who were admitted to the Radiation Oncology Department of Eskisehir Osmangazi University Medical Faculty from January 2004 to December 2013...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28500412/-hereditary-breast-and-ovarian-cancer
#9
REVIEW
S F Lax
Hereditary breast and ovarian carcinomas are frequently caused by germline mutations of the BRCA1 and BRCA2 genes (BRCA1/2 syndromes) and are often less associated with other hereditary syndromes such as Li-Fraumeni and Peutz-Jeghers. The BRCA1/2 proteins have a special role in DNA repair. Therefore, loss of function due to mutation causes an accumulation of mutations in other genes and subsequent tumorigenesis at an early age. BRCA1/2 mutations are irregularly distributed over the length of the genes without hot spots, although special mutations are known...
May 12, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28493609/second-cancer-risk-assessments-after-involved-site-radiotherapy-for-mediastinal-hodgkin-lymphoma
#10
Michalis Mazonakis, Efrossyni Lyraraki, John Damilakis
PURPOSE: This study was conducted to provide second cancer risk assessments attributable to involved-site radiotherapy (ISRT) of mediastinal Hodgkin lymphoma (HL) and to compare these risks with those from the conventional involved-field radiation therapy (IFRT). METHODS: Both ISRT and IFRT plans were made for 11 patients (6 females, 5 males) with HL in the region of mediastinum. All three-dimensional plans involved 6 MV photon beams and delivered 30 Gy to the target site...
May 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28489662/metastasis-of-a-renal-collecting-duct-adenocarcinoma-to-the-oral-cavity-after-tooth-extraction
#11
Suna Erkilic, Aydin Keskinruzgar, Zehra Bozdag, Omer Gunhan
Metastatic tumors rarely occur in the oral cavity. The most common of the oral metastases are lung cancers in males, and breast and genital cancers in females. The most common primary tumor metastasis to the oral cavity is from the lung, kidney, liver, prostate, and colorectal cancers. The metastatic lesions are similar to oral lesions such as pyogenic granuloma, giant cell lesions, gingival polyps, hemangioma, peripheral fibroma, and adenoid squamous cell carcinoma. Therefore, the diagnosis of primary tumors is challenging...
May 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28487467/overall-survival-and-clinical-characteristics-of-brca-associated-cholangiocarcinoma-a-multicenter-retrospective-study
#12
Talia Golan, Maria Raitses-Gurevich, Robin K Kelley, Andrea G Bocobo, Ayelet Borgida, Rachna T Shroff, Spring Holter, Steven Gallinger, Daniel H Ahn, Dan Aderka, Jain Apurva, Tanois Bekaii-Saab, Eitan Friedman, Milind Javle
BACKGROUND: Biliary tract malignancies, in particular cholangiocarcinomas (CCA), are rare tumors that carry a poor prognosis. BRCA2 mutation carriers have an increased risk of developing CCA with a reported relative risk of ∼5 according to the Breast Cancer Linkage Consortium. In addition to this risk, there are potential therapeutic implications in those harboring somatic and/or germline (GL) BRCA mutations. Therefore, it is important to define the clinical characteristics of GL/somatic BRCA1/2 variants in CCA patients...
May 9, 2017: Oncologist
https://www.readbyqxmd.com/read/28487463/male-breast-cancer-as-a-second-primary-cancer-increased-risk-following-lymphoma
#13
Deborah E Farr, Alexandra Thomas, Seema Ahsan Khan, Mary C Schroeder
BACKGROUND: Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with prior MBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported. MATERIALS AND METHODS: Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973-2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) of MBC as SPC were estimated, along with incidence rates and trends...
May 9, 2017: Oncologist
https://www.readbyqxmd.com/read/28484492/relationships-between-global-dna-methylation-in-circulating-white-blood-cells-and-breast-cancer-risk-factors
#14
REVIEW
Nayha Chopra-Tandon, Haotian Wu, Kathleen F Arcaro, Susan R Sturgeon
It is not yet clear whether white blood cell DNA global methylation is associated with breast cancer risk. In this review we examine the relationships between multiple breast cancer risk factors and three markers of global DNA methylation: LINE-1, 5-mdC, and Alu. A literature search was conducted using Pubmed up to April 1, 2016, using combinations of relevant outcomes such as "WBC methylation," "blood methylation," "blood LINE-1 methylation," and a comprehensive list of known and suspected breast cancer risk factors...
2017: Journal of Cancer Epidemiology
https://www.readbyqxmd.com/read/28480506/county-level-cumulative-environmental-quality-associated-with-cancer-incidence
#15
Jyotsna S Jagai, Lynne C Messer, Kristen M Rappazzo, Christine L Gray, Shannon C Grabich, Danelle T Lobdell
BACKGROUND: Individual environmental exposures are associated with cancer development; however, environmental exposures occur simultaneously. The Environmental Quality Index (EQI) is a county-level measure of cumulative environmental exposures that occur in 5 domains. METHODS: The EQI was linked to county-level annual age-adjusted cancer incidence rates from the Surveillance, Epidemiology, and End Results (SEER) Program state cancer profiles. All-site cancer and the top 3 site-specific cancers for male and female subjects were considered...
May 8, 2017: Cancer
https://www.readbyqxmd.com/read/28476483/cancer-incidence-and-mortality-in-china-2013
#16
Wanqing Chen, Rongshou Zheng, Siwei Zhang, Hongmei Zeng, Changfa Xia, Tingting Zuo, Zhixun Yang, Xiaonong Zou, Jie He
OBJECTIVE: National Central Cancer Registry of China (NCCRC) updated nationwide statistics of cancer incidence and mortality in China using population-based cancer registration data in 2013 from all available cancer registries. METHODS: In 2016, 255 registries' data were qualified and included in this analysis. We estimated numbers of new cancer cases and deaths in China in 2013 using age-specific rates and corresponding national population stratified by area, sex, age group (0, 1-4, 5-9, 10-14…85+) and cancer type...
May 2, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28469855/a-case-of-her2-positive-male-occult-breast-carcinoma-with-skin-and-lymph-node-metastases-that-exhibited-complete-response-to-trastuzumab-monotherapy
#17
Kouichi Kuninaka, Ryo Takahashi, Yutaka Nakagawa, Tadashi Nishimaki
Metastatic male occult HER2-positive breast cancer can be successfully treated with trastuzumab monotherapy.
May 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28463158/postmastectomy-radiation-therapy-is-associated-with-improved-survival-in-node-positive-male-breast-cancer-a-population-analysis
#18
Matthew J Abrams, Paul P Koffer, David E Wazer, Jaroslaw T Hepel
PURPOSE: Because of its rarity, there are no randomized trials investigating postmastectomy radiation therapy (PMRT) in male breast cancer. This study retrospectively examines the impact of PMRT in male breast cancer patients in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database. METHODS AND MATERIALS: The SEER database 8.3.2 was queried for men ages 20+ with a diagnosis of localized or regional nonmetastatic invasive ductal/lobular carcinoma from 1998 to 2013...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28459460/magea1-interacts-with-fbxw7-and-regulates-ubiquitin-ligase-mediated-turnover-of-nicd1-in-breast-and-ovarian-cancer-cells
#19
J Zhao, Y Wang, C Mu, Y Xu, J Sang
Melanoma-associated antigen A1 (MAGEA1) is member of the MAGE gene family that is expressed in male germ line cells and placenta under normal physiological conditions. Although MAGEA1's expression levels have been evaluated as one of the cancer testis (CT) antigens for immunotherapy in melanoma and several other cancers, its functional role and signaling mechanisms are largely unknown. In this study, we examined the functional involvement and signaling mechanisms of MAGEA1 in breast and ovarian cancer cells...
May 1, 2017: Oncogene
https://www.readbyqxmd.com/read/28454502/prediction-of-cardiovascular-risk-in-cancer-patients-of-south-india-using-who-ish-risk-prediction-charts-and-framingham-score-a-prospective-study
#20
M G Rajanandh, S Suresh, K Manobala, R Nandhakumar, G Jaswanthi, S Neha
Objective Despite the fact that cancer and heart diseases are interconnected, there is lack of information about the prevalence of cardiovascular risk in cancer patients in the South Indian population. With this background, the present study sought to predict the cardiovascular disease in cancer patients. Methods A prospective, cross-sectional study was conducted in the Department of Medical Oncology, Sri Ramachandra University and Hospital, India. Patients' demographic details, medical information, height, weight, body mass index, blood pressure, total cholesterol and HDL-cholesterol were measured...
January 1, 2017: Journal of Oncology Pharmacy Practice
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