keyword
https://read.qxmd.com/read/38532729/serplulimab-monotherapy-in-extensive-stage%C3%A2-small-cell-lung-cancer-with-brain-metastasis-a-case-report
#21
JOURNAL ARTICLE
Xudong Xiang, Heng Li, Bao Lei, Benchao Chen, Gaofeng Li
Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with limited treatment options, especially for extensive-stage (ES) patients. We present a case of a 70-year-old male with ES-SCLC and asymptomatic brain metastasis who opted for immune monotherapy with serplulimab (an anti-PD-1 antibody). After four cycles, the patient achieved a confirmed partial response and a progression-free survival of over 1 year. Moreover, we observed a consistent decline in tumor biomarkers, and brain MRI indicated reduced metastatic activity...
March 27, 2024: Immunotherapy
https://read.qxmd.com/read/38531194/safety-of-local-anesthesia-in-endovascular-treatment-of-aneurysms-a-systematic-review-and-meta-analysis
#22
REVIEW
Sávio Batista, Marcio Yuri Ferreira, Jordana Borges, Leonardo de Barros Oliveira, Eric Slawka, Raphael Bertani, Raphael Muszkat Besborodco, Jhon E Bocanegra-Becerra, Dan Zimelewicz Oberman, José Alberto Almeida Filho
BACKGROUND: Endovascular treatment of intracranial aneurysms (EVTIAs) is increasingly popular due to its minimally invasive nature and high success rate. While general anesthesia (GA) has been the historical preference for EVTIAs, there's growing interest in local anesthesia (LA). However, concerns persist about LA safety for EVTIAs. Therefore, we conducted a systematic review and meta-analysis to assess LA safety for EVTIAs. METHODS: Following PRISMA guidelines, we searched PubMed, Embase, and Web of Science databases...
March 25, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38528171/jump-starting-life-balancing-transposable-element-co-option-and-genome-integrity-in-the-developing-mammalian-embryo
#23
REVIEW
Marlies E Oomen, Maria-Elena Torres-Padilla
Remnants of transposable elements (TEs) are widely expressed throughout mammalian embryo development. Originally infesting our genomes as selfish elements and acting as a source of genome instability, several of these elements have been co-opted as part of a complex system of genome regulation. Many TEs have lost transposition ability and their transcriptional potential has been tampered as a result of interactions with the host throughout evolutionary time. It has been proposed that TEs have been ultimately repurposed to function as gene regulatory hubs scattered throughout our genomes...
March 25, 2024: EMBO Reports
https://read.qxmd.com/read/38525974/influenza-and-covid-19-vaccination-in-2023-a-descriptive-analysis-in-two-italian-research-and-teaching-hospitals-is-the-on-site-strategy-effective
#24
JOURNAL ARTICLE
Pier Mario Perrone, Simone Villa, Giuseppina Maria Raciti, Laura Clementoni, Valentina Vegro, Francesco Scovenna, Augusto Altavilla, Adriana Monica Tomoiaga, Valentina Beltrami, Ilaria Bruno, Marcello Vaccargiu, Elisa Astorri, Navpreet Tiwana, Matteo Letzgus, Peter Johannes Schulz, Fabrizio Ernesto Pregliasco, Silvana Castaldi
INTRODUCTION: Vaccinations represent an extremely effective tool for the prevention of certain infectious diseases - such as influenza and COVID-19 -, particularly for those categories at risk due to both their frail condition or professional exposure, such as healthcare workers. The aim of this study is to describe the course of the anti-influenza and anti-COVID-19 vaccination campaign at two Research Hospitals in Milan, Italy. STUDY DESIGN: Multicentre, cross-sectional study...
March 21, 2024: Annali di Igiene: Medicina Preventiva e di Comunità
https://read.qxmd.com/read/38524656/spot-scanning-proton-therapy-for-unresectable-bulky-retroperitoneal-dedifferentiated-liposarcoma-a-case-report
#25
JOURNAL ARTICLE
Koichiro Nakajima, Hiromitsu Iwata, Shuo Sudo, Toshiyuki Toshito, Kensuke Hayashi, Masaki Sunagawa, Yukihiro Yokoyama, Hiroyuki Ogino
The development of effective treatment strategies for unresectable retroperitoneal sarcoma is desirable. Herein, we suggest that definitive proton therapy (PT) could be a promising treatment option, regardless of the large size of the tumor. A 52-year-old man presented with a discomfort of the lower abdomen. Computed tomography revealed a retroperitoneal tumor, measuring over 20 cm in the largest dimensions, which was surrounded by the gastrointestinal (GI) tract. Biopsy revealed dedifferentiated liposarcoma...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524650/coexistence-of-ovarian-cancer-and-peritoneal-tuberculosis-a-case-report
#26
JOURNAL ARTICLE
Akitoshi Yamamura, Kentaro Sekiyama, Miki Otsuki, Akiko Abe, Yuki Kashihara, Yuki Kozono, Akiko Okuda, Yumiko Yoshioka, Toshihiro Higuchi
Peritoneal tuberculosis (TB) is known to mimic advanced ovarian cancer. In this case report, we describe a unique case of ovarian cancer (endometrioid carcinoma grade 3) at the International Federation of Gynecology and Obstetrics (FIGO) stage IC1 with pulmonary and peritoneal TB, which was suspected preoperatively to be a coexistence of advanced ovarian cancer and pulmonary TB. A 68-year-old woman presented with a prominent abdominal mass and fever. Laboratory investigations, imaging, and sputum analysis indicated a probable diagnosis of ovarian cancer at FIGO stage IIIC, characterized by peritoneal dissemination and para-aortic lymph node metastasis, which was further complicated by coexisting pulmonary TB...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524557/smallholders-vulnerability-in-the-maize-market-an-analysis-of-marketing-channels-to-improve-the-role-of-cooperatives-in-benin
#27
JOURNAL ARTICLE
Godfrid Erasme Ibikoule, Jaehyeon Lee, Lise Audrey Godonou
Smallholder households in developing countries often face challenges related to market access. Despite being proposed as a potential solution, cooperatives in the north of Benin have reportedly failed to effectively address this issue. The alternatives channels used by smallholder famers and the factors that influence their choices remain unclear. This paper adopts a mixed approach, combining qualitative analysis with quantitative methods, particularly the multivariate probit model, to investigate the distribution channels of maize used by farmers in the Kandi district of Benin...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524382/trigeminal-neuralgia-revealing-an-epidermoid-cyst-impinging-on-the-vth-cranial-nerve-a-case-report
#28
Messaoud Ola, Guelzim Yousra, Sqalli Houssaini Abdelkader, Fikri Meriem, Jiddane Mohamed, Touarsa Firdaous
Intracranial epidermoid cysts, also referred to as intracranial primary cholesteatomas, are uncommon, benign tumors characterized by slow, linear growth patterns akin to normal epidermal tissue. They typically become symptomatic around age 43, with a slight female predominance, and are most frequently located in the cerebellopontine angle. This summary presents the case of a 62-year-old woman suffering from paroxysmal excruciating pain of the right hemiface, indicative of trigeminal neuralgia, linked to an intracranial epidermoid cyst in the cerebellopontine angle...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38524207/should-i-opt-for-intracytoplasmic-sperm-injection-or-should-i-not-high-tech-no-matter-what
#29
EDITORIAL
Lusine Aghajanova
No abstract text is available yet for this article.
March 2024: F&S reports
https://read.qxmd.com/read/38523435/impact-of-headache-frequency-and-preventive-treatment-failure-on-quality-of-life-disability-and-direct-and-indirect-costs-among-individuals-with-episodic-migraine-in-the-united-states
#30
JOURNAL ARTICLE
David W Dodick, Michael L Reed, Lulu Lee, Bridget L Balkaran, Kandavadivu Umashankar, Mousam Parikh, Pranav Gandhi, Dawn C Buse
OBJECTIVE: To evaluate unmet needs among individuals with episodic migraine (EM) in the United States (US). BACKGROUND: Data are limited on the impact of headache frequency (HF) and preventive treatment failure (TF) on the burden of migraine in the US. METHODS: A retrospective, cross-sectional analysis of 2019 National Health and Wellness Survey (NHWS) data was conducted from an opt-in online survey that identified respondents (aged ≥18 years) in the US with self-reported physician-diagnosed migraine...
March 24, 2024: Headache
https://read.qxmd.com/read/38522333/omission-of-breast-surgery-in-selected-breast-cancer-patients-with-excellent-response-to-neoadjuvant-systemic-therapy
#31
JOURNAL ARTICLE
Marios-Konstantinos Tasoulis, Samantha Muktar, Ian Smith, Nicola Roche, Fiona MacNeill
Modern neoadjuvant systemic therapy (NST) can result in high pathologic complete response rates (pCR) in triple negative (TN) and human epidermal growth factor receptor 2 positive (HER2+) breast cancer. The role of surgery is, therefore, being reconsidered in this rapidly evolving field. This report presents oncological outcomes of seven patients with TN or HER2+ breast cancer, with exceptional response to NST, and a post-NST image-guided vacuum assisted biopsy showing no residual disease (ypT0), who opted not to have breast surgery...
March 19, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38522070/a-bacterial-toxin-co-opts-caspase-3-to-disable-active-gasdermin-d-and-limit-macrophage-pyroptosis
#32
JOURNAL ARTICLE
Skylar S Wright, Chengliang Wang, Atri Ta, Morena S Havira, Jianbin Ruan, Vijay A Rathinam, Sivapriya Kailasan Vanaja
During infections, host cells are exposed to pathogen-associated molecular patterns (PAMPs) and virulence factors that stimulate multiple signaling pathways that interact additively, synergistically, or antagonistically. The net effect of such higher-order interactions is a vital determinant of the outcome of host-pathogen interactions. Here, we demonstrate one such complex interplay between bacterial exotoxin- and PAMP-induced innate immune pathways. We show that two caspases activated during enterohemorrhagic Escherichia coli (EHEC) infection by lipopolysaccharide (LPS) and Shiga toxin (Stx) interact in a functionally antagonistic manner; cytosolic LPS-activated caspase-11 cleaves full-length gasdermin D (GSDMD), generating an active pore-forming N-terminal fragment (NT-GSDMD); subsequently, caspase-3 activated by EHEC Stx cleaves the caspase-11-generated NT-GSDMD to render it nonfunctional, thereby inhibiting pyroptosis and interleukin-1β maturation...
March 22, 2024: Cell Reports
https://read.qxmd.com/read/38520589/inorganic-arsenic-in-seaweed-a-fast-hplc-icp-ms-method-without-coelution-of-arsenosugars
#33
JOURNAL ARTICLE
Rebecca Sim, Marta Weyer, Ásta H Pétursdóttir
Seaweed is becoming increasingly popular in the Western diet as consumers opt for more sustainable food sources. However, seaweed is known to accumulate high levels of arsenic-which may be in the form of carcinogenic inorganic arsenic (iAs). Here we propose a fast method for the routine measurement of iAs in seaweed using HPLC-ICP-MS without coelution of arsenosugars that may complicate quantification. The developed method was optimised using design of experiments (DOE) and tested on a range of reference materials including TORT-3 (0...
March 23, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38519950/the-evaluation-of-synchronous-and-asynchronous-online-learning-student-experience-learning-outcomes-and-cognitive-load
#34
JOURNAL ARTICLE
Chih-Tsung Hung, Shou-En Wu, Yi-Hsien Chen, Chen-Yeu Soong, Chien-Ping Chiang, Wei-Ming Wang
BACKGROUND: The abrupt onset of the COVID-19 pandemic compelled universities to swiftly establish online teaching and learning environments that were not only immediately deployable but also conducive to high-quality education. This study aimed to compare the effectiveness of the online synchronous and asynchronous teaching formats in the dermatology lecture for undergraduate medical students, including academic performance, self-efficacy, and cognitive load. METHODS: A total of 170 fourth-year undergraduate medical students attending the dermatology lecture were included...
March 22, 2024: BMC Medical Education
https://read.qxmd.com/read/38519372/using-a-survey-analyzing-the-current-situation-of-allergic-march-in-elementary-and-junior-high-school-students-of-oyama-and-tochigi-cities-japan
#35
JOURNAL ARTICLE
Hamid Abid, Yusuke Ando, Manabu Miyamoto, Shigemi Yoshihara
BACKGROUND: Over the past few decades, allergic diseases have become more prevalent and impact around 20% of the global population. There is clinical significance of allergic march as it places a burden on the quality of life of children and their families. OBJECTIVES: To assess the current situation of allergy conditions experienced by children attending elementary and junior high schools in Oyama and Tochigi cities, Japan. METHODS: A letter was sent to parents informing them about an opt-in online survey concerning children's allergies along with a weblink and a QR code...
March 15, 2024: Pediatrics and Neonatology
https://read.qxmd.com/read/38517453/been-there-done-that-the-impact-of-the-novelty-of-penile-vaginal-intercourse-pvi-and-participants-sex-on-delay-and-probability-discounting-of-pvi
#36
JOURNAL ARTICLE
Wayne R Hawley, Gregory D Morrow
Delay and probability discounting tasks are useful for understanding aspects of decision making. The current study, which employed a mixed-model design to assess discounting of penile-vaginal intercourse (PVI), was conducted online with male and female participants recruited from Prolific ( N  = 300; mean age = 34.1 years). Results of the novel delay and probability discounting tasks indicated that as the delay to PVI increased, or as PVI became less certain to occur, participants were instead more likely to choose to receive oral sex, the reward initially indicated as less desirable...
March 22, 2024: Journal of Sex Research
https://read.qxmd.com/read/38516916/coincidence-measurements-of-photodouble-ionization-of-benzene-and-thiophene
#37
JOURNAL ARTICLE
Nicholas L Wong, Jason Howard, Ben Delaney, Emma Sokell, Paola Bolognesi, Lorenzo Avaldi
Photodouble ionization (PDI) triple-differential cross sections (TDCSs) of benzene and thiophene have been measured in electron-electron coincidence experiments under 10-10 eV and 20-20 eV equal energy sharing conditions. A multi-Gaussian fit method has been employed to characterize the TDCSs. The trends and features observed for benzene and thiophene do highlight differences with helium most likely from molecular PDI contributions to the TDCS. A comparison with the well-known helium PDI TDCS for equal energy sharing conditions [Avaldi and Huetz J...
March 22, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38516473/visual-field-improvement-and-electrode-extrusion-prevention-by-extended-endaural-incision-with-cavity-obliteration-for-cochlear-implantation-in-ears-after-canal-wall-down-mastoidectomy-experience-of-four-cases
#38
JOURNAL ARTICLE
Kohei Fukuda, Keiji Tabuchi, Yuki Hirose, Shin Matsumoto, Masahiro Adachi
There is no global consensus on the surgical technique of cochlear implantation (CI) in ears with an open cavity after canal wall-down (CWD) mastoidectomy. Here, we report CI surgery with an endaural incision for the ears after CWD mastoidectomy. The endaural incision was extended upward to obliterate the open cavity of the temporal fascial flap. The endaural incision was extended downward to close the open cavity inlet. After inserting the implanted electrode, the open cavity was obliterated using a temporal fascial flap, and the cavity was closed at the inlet...
February 2024: Curēus
https://read.qxmd.com/read/38515601/evaluating-the-metropolitan-public-health-preparedness-for-pandemics-using-entropy-topsis-if
#39
JOURNAL ARTICLE
Jin Liu, Allen Wood Liu, Xingye Li, Hui Li, Wenwei Luo, Wei Chen
INTRODUCTION: Metropolitan governance's efficacy is regularly gauged by its capability for public health preparedness, a critical component, particularly in the post-pandemic climate, as global cities reassess their mitigation abilities. This process has broader implications, curbing mortality rates and amplifying sustainability. Current methodologies for preparedness assessment lean primarily on either Subjective Evaluation-Based Assessment (SBA), predicated on experts' input on various capacity indicators, or they opt for Data-Based quantitative Assessments (DBA), chiefly utilizing public statistic data...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38515533/resource-selection-by-sarda-cattle-in-a-mediterranean-silvopastoral-system
#40
JOURNAL ARTICLE
Marco Acciaro, Marco Pittarello, Mauro Decandia, Maria Sitzia, Valeria Giovanetti, Giampiero Lombardi, Patrick E Clark
Knowledge of how grazing cattle utilize heterogeneous landscapes in Mediterranean silvopastoral areas is scarce. Global positioning systems (GPS) to track animals, together with geographic information systems (GIS), can relate animal distribution to landscape features. With the aim to develop a general spatial model that provides accurate prediction of cattle resource selection patterns within a Mediterranean mountainous silvopastoral area, free-roaming Sarda cows were fitted with GPS collars to track their spatial behaviors...
2024: Frontiers in Veterinary Science
keyword
keyword
24566
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.