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https://www.readbyqxmd.com/read/27926655/maternal-morbidity-after-previable-prelabor-rupture-of-membranes
#1
Sarah K Dotters-Katz, Alexis Panzer, Matthew R Grace, Marcela C Smid, J Adeolu Keku, Catherine J Vladutiu, Kim A Boggess, Tracy A Manuck
OBJECTIVE: To identify risk factors for maternal morbidity after previable prelabor rupture of membranes (PROM). METHODS: We conducted a case-control study of singleton and twin pregnancies complicated by previable PROM (14.0-22.9 weeks of gestation) at a single tertiary care referral institution, 2000-2015. Pregnancies complicated by fetal anomalies, previable PROM within 2 weeks of chorionic villus sampling or amniocentesis, and those with contraindications to expectant management (eg, chorioamnionitis) were excluded...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926650/group-b-streptococci-screening-before-repeat-cesarean-delivery-a-cost-effectiveness-analysis
#2
Catherine M Albright, Caitlin MacGregor, Desmond Sutton, Meena Theva, Brenna L Hughes, Erika F Werner
OBJECTIVE: To estimate the cost-effectiveness of universal group B streptococci (GBS) screening in women with a singleton pregnancy planning a repeat cesarean delivery. METHODS: We conducted a decision analysis from a health care perspective to compare the cost-effectiveness of GBS screening for women planning a repeat cesarean delivery. With universal screening, all GBS-positive women who labored before a scheduled cesarean delivery received antibiotic prophylaxis...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27923328/modeling-stroma-induced-drug-resistance-in-a-tissue-engineered-tumor-model-of-ewing-sarcoma
#3
Marco Santoro, Brian A Menegaz, Salah-Eddine Lamhamedi-Cherradi, Eric R Molina, Danielle Wu, Waldemar Priebe, Joseph A Ludwig, Antonios G Mikos
Three-dimensional (3D) tumor models are gaining traction in the research community given their capacity to mimic aspects of the tumor microenvironment absent in monolayer systems. In particular, the ability to spatiotemporally control cell placement within ex vivo 3D systems has enabled the study of tumor-stroma interactions. Furthermore, by regulating biomechanical stimuli, one can reveal how biophysical cues affect stromal cell phenotype and how their phenotype impacts tumor drug sensitivity. Both tumor architecture and shear force have profound effects on Ewing sarcoma (ES) cell behavior and are known to elicit ligand-mediated activation of the insulin-like growth factor-1 receptor (IGF-1R), thereby mediating resistance of ES cells to IGF-1R inhibitors...
December 6, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27922795/breast-cancer-risk-reduction-decisions-of-the-brca-positive-patient-an-observational-study-at-a-single-institution
#4
Dana Johns, Jay Agarwal, Layla Anderson, Jian Ying, Wendy Kohlmann
BACKGROUND: BRCA1 and BRCA2 gene mutations carry with them a 50%-80% risk of developing breast cancer. The best choice for managing breast cancer risk in patients with a BRCA1/2 mutation is a highly personal decision. Options for risk management include surveillance with multiple modalities or prophylactic surgical intervention. The goal of this study was to gain a better understanding of contributing factors affecting the decision for managing breast cancer risk made by patients who are BRCA mutation positive and cancer free...
December 6, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27920872/anterior-and-posterior-suprasellar-extensions-of-a-symmetrical-trilobed-nonfunctional-giant-pituitary-adenoma-in-the-sagittal-plane-a-case-report-and-review-of-literature
#5
Rushabh M Vakharia, Roman Kremen, Ajit Vakharia, Obed Adarkwah, Gordon Anderson
INTRODUCTION: To the best of our knowledge, the presence of a trilobed nonfunctional giant pituitary adenoma has never been described before in the literature. These tumors present unique diagnostic and therapeutic challenges. Tumors of this etiology can be managed with pharmacologic treatment or aggressive surgical intervention. The following case illustrates an unique visual presentation of a giant pituitary adenoma. CASE PRESENTATION: We report the case of a 40-year-old Hispanic man who presented with new onset seizures...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920020/repeated-failed-non-invasive-prenatal-testing-in-a-woman-with-immune-thrombocytopenia-and-antiphospholipid-syndrome-lessons-learnt
#6
C Y Y Hui, W C Tan, E L Tan, L K Tan
We present a case of a 37-year-old Chinese woman (gravida 4 para 0) with a history of immune thrombocytopenia and type IIb antiphospholipid syndrome. She was started on 100 mg of aspirin, 20 mg of prednisolone and 20 mg of subcutaneous low-molecular-weight heparin daily for her fourth pregnancy. She opted for non-invasive prenatal testing for aneuploidy screening but had failed results three times consecutively from insufficient fetal cfDNA initially or high variance in cfDNA counts on redraws. She declined invasive karyotyping...
December 5, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27916775/a-case-report-of-adenosquamous-cell-carcinoma-of-the-duodenal-papilla
#7
Yuki Segi, Akira Hashimoto, Hiroki Yukimoto, Naohiko Yoshizawa, Masatoshi Aoki, Hiroyuki Fuke, Hiroyuki Kawabata, Atsuya Shimizu, Ken Ichikawa, Hiroshi Nakano
Adenosquamous carcinoma of the duodenal papilla is rare. A 73-year-old man was referred to the Saiseikai-Matsusaka General Hospital with upper abdominal pain and liver dysfunction. Computed tomography (CT) revealed dilatation of the common bile duct (CBD) and intrahepatic bile duct along with a tumor in the distal CBD. The tumor showed enhancement in the arterial phase on contrast-enhanced CT. We performed endoscopic retrograde cholangiopancreatography and noted a red, erosive, bleeding mass in the duodenal papilla with obstruction of the distal CBD, and dilatation of the CBD...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27915288/modification-of-orthogonal-trnas-unexpected-consequences-for-sense-codon-reassignment
#8
Wil Biddle, Margaret A Schmitt, John D Fisk
Breaking the degeneracy of the genetic code via sense codon reassignment has emerged as a way to incorporate multiple copies of multiple non-canonical amino acids into a protein of interest. Here, we report the modification of a normally orthogonal tRNA by a host enzyme and show that this adventitious modification has a direct impact on the activity of the orthogonal tRNA in translation. We observed nearly equal decoding of both histidine codons, CAU and CAC, by an engineered orthogonal M. jannaschii tRNA with an AUG anticodon: tRNA(Opt) We suspected a modification of the tRNA(Opt)AUG anticodon was responsible for the anomalous lack of codon discrimination and demonstrate that adenosine 34 of tRNA(Opt)AUG is converted to inosine...
December 1, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27913050/congenital-high-airway-obstruction-syndrome-chaos-a-perinatal-autopsy-case-report
#9
Manasi Gosavi, Lalit Kumar, Ashwini Ratnakar, Hema Bannur
INTRODUCTION: Congenital High Airway Obstruction Syndrome (CHAOS) is a rare anomaly where a partial or complete obstruction of upper airway is seen. As a consequence, the foetus develops enlarged lungs, inverted or flattened diaphragm and ascites. The pathological findings in a case of CHAOS is presented. CASE REPORT: A 28-year-old primigravida presented with a history of 5 months of amenorrhoea. Ultrasonography revealed enlarged echogenic lungs, cardiac mid-position, inverted diaphragm, foetal ascites and talipes of left foot...
October 26, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27911487/external-inspection-of-compliance-with-standards-for-improved-healthcare-outcomes
#10
REVIEW
Gerd Flodgren, Daniela C Gonçalves-Bradley, Marie-Pascale Pomey
BACKGROUND: Inspection systems are used in healthcare to promote quality improvements (i.e. to achieve changes in organisational structures or processes, healthcare provider behaviour and patient outcomes). These systems are based on the assumption that externally promoted adherence to evidence-based standards (through inspection/assessment) will result in higher quality of healthcare. However, the benefits of external inspection in terms of organisational-, provider- and patient-level outcomes are not clear...
December 2, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27910471/the-national-ignition-facility-modular-kirkpatrick-baez-microscope
#11
L A Pickworth, J Ayers, P Bell, N F Brejnholt, J G Buscho, D Bradley, T Decker, S Hau-Riege, J Kilkenny, T McCarville, T Pardini, J Vogel, C Walton
Current two-dimensional X-ray imaging at the National Ignition Facility (NIF) uses time resolved pinhole cameras with ∼10-25 μm pinholes. This method has limitations in the smallest resolvable features that can be imaged with reasonable photon statistics for inertial confinement fusion (ICF) applications. ICF sources have a broadband self-emission spectrum that causes the pinhole images obtained, through thin foil filters, to contain a similarly broadband spectrum complicating the interpretation of structure in the source...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909688/the-danger-signal-extracellular-atp-is-an-inducer-of-fusobacterium-nucleatum-biofilm-dispersal
#12
Qinfeng Ding, Kai Soo Tan
Plaque biofilm is the primary etiological agent of periodontal disease. Biofilm formation progresses through multiple developmental stages beginning with bacterial attachment to a surface, followed by development of microcolonies and finally detachment and dispersal from a mature biofilm as free planktonic bacteria. Tissue damage arising from inflammatory response to biofilm is one of the hallmark features of periodontal disease. A consequence of tissue damage is the release of ATP from within the cell into the extracellular space...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27909212/black-carbon-emission-reduction-strategies-in-healthcare-industry-for-effective-global-climate-change-management
#13
Emilia Mmbando Raila, David O Anderson
Climate change remains one of the biggest threats to life on earth to date with black carbon (BC) emissions or smoke being the strongest cause after carbon dioxide (CO2). Surprisingly, scientific evidence about black carbon emissions reduction in healthcare settings is sparse. This paper presents new research findings on the reduction of black carbon emissions from an observational study conducted at the UN Peacekeeping Operations (MINUSTAH) in Haiti in 2014. Researchers observed 20 incineration cycles, 30 minutes for each cycle of plastic and cardboard sharps healthcare waste (HCW) containers ranged from 3 to 14...
November 30, 2016: Waste Management & Research
https://www.readbyqxmd.com/read/27906314/biophysical-modelling-of-phytoplankton-communities-from-first-principles-using-two-layered-spheres-equivalent-algal-populations-eap-model-erratum
#14
Lisl Robertson Lain, Stewart Bernard, Mark W Matthews
We regret that the Rrs spectra shown for the EAP modelled high biomass validation in Fig. 7 [Opt. Express, 22, 16745 (2014)] are incorrect. They are corrected here. The closest match of modelled to measured effective diameter is for a generalised 16 μm dinoflagellate population and not a 12 μm one as previously stated. These corrections do not affect the discussion or the conclusions of the paper.
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906256/method-to-determine-the-degrees-of-consistency-in-experimental-datasets-of-perceptual-color-differences
#15
Samuel Morillas, Luis Gómez-Robledo, Rafael Huertas, Manuel Melgosa
We propose a fuzzy method to analyze datasets of perceptual color differences with two main objectives: to detect inconsistencies between couples of color pairs and to assign a degree of consistency to each color pair in a dataset. This method can be thought as the outcome of a previous one developed for a similar purpose [J. Mod. Opt.56, 1447 (2009)JMOPEW0950-034010.1080/09500340902944038], whose performance is compared with the proposed one. In this work, we present the results achieved using the dataset employed to develop the current CIE/ISO color-difference formula, CIEDE2000, but the method could be applied to any dataset...
December 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/27906242/printed-optics-phantoms-for-quantitative-deep-tissue-fluorescence-imaging-publisher-s-note
#16
Brian Z Bentz, Anna G Bowen, Dergan Lin, Daniel Ysselstein, Davin H Huston, Jean-Christophe Rochet, Kevin J Webb
This note points out a number of corrections that were omitted from the published version of the article [Opt. Lett.41, 5230 (2016)OPLEDP0146-959210.1364/OL.41.005230].
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27906221/highly-sensitive-fiber-laser-ultrasound-hydrophones-for-sensing-and-imaging-applications-publisher-s-note
#17
Di Liu, Yizhi Liang, Long Jin, Huojiao Sun, Linghao Cheng, Baoi-Ou Guan
This note corrects the range of acoustic frequencies mentioned in the opening paragraph of Opt. Lett.41, 4530 (2016)OPLEDP0146-959210.1364/OL.41.004530 as having rarely been investigated.
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27906129/the-evolutionary-origin-of-bilaterian-smooth-and-striated-myocytes
#18
Thibaut Brunet, Antje Hl Fischer, Patrick Rh Steinmetz, Antonella Lauri, Paola Bertucci, Detlev Arendt
The dichotomy between smooth and striated myocytes is fundamental for bilaterian musculature, but its evolutionary origin is unsolved. In particular, interrelationships of visceral smooth muscles remain unclear. Absent in fly and nematode, they have not yet been characterized molecularly outside vertebrates. Here, we characterize expression profile, ultrastructure, contractility and innervation of the musculature in the marine annelid Platynereis dumerilii and identify smooth muscles around the midgut, hindgut and heart that resemble their vertebrate counterparts in molecular fingerprint, contraction speed, and nervous control...
December 1, 2016: ELife
https://www.readbyqxmd.com/read/27904170/twenty-five-year-old-woman-with-bilateral-borderline-ovarian-tumour-desiring-to-preserve-fertility-case-report-and-literature-review-on-the-current-state-of-fertility-preservation-in-women-with-borderline-ovarian-tumours
#19
S Findeklee, L Lotz, K Heusinger, I Hoffmann, R Dittrich, M W Beckmann
Borderline ovarian tumours are semimalignant tumours occurring unilaterally or bilaterally with a peak incidence among women of reproductive age. Since the affected women often wish to preserve fertility, particular precautions must be taken when counselling the patient and obtaining consent prior to planning an individual treatment. Options for preserving fertility include an organ-sparing surgical procedure and cryopreservation of oocytes and/or ovarian tissue. In this article, we report on a 25-year-old patient with a bilateral seromucinous borderline tumour who desired all fertility-preserving options...
November 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/27903078/why-prevention-of-repeat-abortion-is-so-challenging-psychosocial-characteristics-of-women-at-risk
#20
Brigitte Leeners, Simone Bieli, Dorothy Huang, Sibil Tschudin
OBJECTIVES: Abortion rates have declined in recent decades; however, the rate of repeat abortion remains high. In order to identify keys to making efficient interventions against repeat abortion, our objectives were: to assess the percentage of repeat abortions in women opting for termination of pregnancy over a period of 1 year; to identify the risk factors for repeat abortion; and to assess the characteristics of women who opted for a further pregnancy termination despite having received standard post-abortion care...
November 30, 2016: European Journal of Contraception & Reproductive Health Care
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