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https://www.readbyqxmd.com/read/29022576/xueshuantong-injection-lyophilized-combined-with-salvianolate-lyophilized-injection-protects-against-focal-cerebral-ischemia-reperfusion-injury-in-rats-through-attenuation-of-oxidative-stress
#1
Fu-Jiang Wang, Shao-Xia Wang, Li-Juan Chai, Yue Zhang, Hong Guo, Li-Min Hu
Salvianolate lyophilized injection (SLI) and Xueshuantong injection (lyophilized) (XST) are two herbal standardized preparations that have been widely used in China for the treatment of acute cerebral infarction. In this study, we investigated the neuroprotective effects of SLI combined with XST in a rat model of middle cerebral artery occlusion-reperfusion (MCAO/R). Wistar rats were subjected to 1.5 h of MCAO followed by reperfusion for 3 h, then were treated with SLI or XST alone, or with their combinations via tail vein injection daily for 3 d...
October 12, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28990357/procedural-learning-across-the-lifespan-a-systematic-review-with-implications-for-atypical-development
#2
REVIEW
Fenny S Zwart, Constance Th W M Vissers, Roy P C Kessels, Joseph H R Maes
This systematic review aimed to investigate procedural learning across the lifespan in typical and atypical development. Procedural learning is essential for the development of everyday skills, including language and communication skills. Although procedural learning efficiency has been extensively studied, there is no consensus yet on potential procedural learning changes during development and ageing. Currently, three conflicting models regarding this trajectory exist: (1) a model of age invariance; (2a) a model with a peak in young adulthood; and (2b) a model with a plateau in childhood followed by a decline...
October 8, 2017: Journal of Neuropsychology
https://www.readbyqxmd.com/read/28984350/thinking-or-feeling-an-exploratory-study-of-maternal-scaffolding-child-mental-state-talk-and-emotion-understanding-in-language-impaired-and-typically-developing-school-aged-children
#3
Nicola Yuill, Sarah Little
BACKGROUND: Mother-child mental state talk (MST) supports children's developing social-emotional understanding. In typically developing (TD) children, family conversations about emotion, cognition, and causes have been linked to children's emotion understanding. Specific language impairment (SLI) may compromise developing emotion understanding and adjustment. AIMS: We investigated emotion understanding in children with SLI and TD, in relation to mother-child conversation...
October 6, 2017: British Journal of Educational Psychology
https://www.readbyqxmd.com/read/28965135/chronic-phase-improvements-in-electrocardiographic-and-echocardiographic-manifestations-of-left-ventricular-hypertrophy-after-alcohol-septal-ablation-for-drug-refractory-hypertrophic-obstructive-cardiomyopathy
#4
Junya Matsuda, Mitsunobu Kitamura, Morimasa Takayama, Yoichi Imori, Junsuke Shibuya, Yoshiaki Kubota, Hideto Sangen, Shunichi Nakamura, Hitoshi Takano, Kuniya Asai, Wataru Shimizu
After alcohol septal ablation (ASA), regression of left ventricular hypertrophy (LVH) has been observed in several studies using echocardiography or cardiac magnetic resonance, and favorable changes of myocardial excitation have been expected. However, no studies have focused on the alteration of electrocardiography (ECG) findings after ASA. Therefore, we evaluated serial changes in ECG parameters during the chronic phase after ASA for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). From 1998 to 2014, we performed 187 ASA procedures in 157 drug-refractory HOCM patients...
September 30, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28918034/a-simple-and-cost-effective-approach-for-in%C3%A2-vitro-production-of-sliced-sirnas-as-potent-triggers-for-rnai
#5
Guihua Sun, Arthur D Riggs
We have studied the molecular properties of in-vitro-transcribed sliced small interfering RNAs (tsli-siRNAs) as an alternative RNAi agent for chemically synthesized siRNA. We describe here a simple and cost-effective procedure for high-purity production of tsli-siRNA using bacteriophage T7 RNA polymerases. tsli-siRNAs exhibit potent gene knockdown effects, with efficacy comparable with that of chemically synthesized sli-siRNAs and classical siRNAs. Furthermore, we found that it is very easy to prepare potent tsli-siRNAs with modified bases, such as 2'-fluorine- or biotin-16-modified tsli-siRNAs...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28887836/a-novel-method-for-quantification-of-beam-s-eye-view-tumor-tracking-performance
#6
Yue-Houng Hu, Marios Myronakis, Joerg Rottmann, Adam Wang, Daniel Morf, Daniel Shedlock, Paul Baturin, Josh Star-Lack, Ross Berbeco
PURPOSE: In-treatment imaging using an electronic portal imaging device (EPID) can be used to confirm patient and tumor positioning. Real-time tumor tracking performance using current digital megavolt (MV) imagers is hindered by poor image quality. Novel EPID designs may help to improve quantum noise response, while also preserving the high spatial resolution of the current clinical detector. Recently investigated EPID design improvements include but are not limited to multi-layer imager (MLI) architecture, thick crystalline and amorphous scintillators, and phosphor pixilation and focusing...
September 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/28886430/story-grammar-elements-and-causal-relations-in-the-narratives-of-russian-hebrew-bilingual-children-with-sli-and-typical-language-development
#7
Sveta Fichman, Carmit Altman, Anna Voloskovich, Sharon Armon-Lotem, Joel Walters
BACKGROUND: While there is general agreement regarding poor performance of children with Specific Language Impairment (SLI) on microstructure measures of narrative production, findings on macrostructure are inconsistent. PURPOSE: The present study analyzed narrative abilities of Russian-Hebrew bilingual preschool children with and without SLI, with a particular focus on story grammar (SG) elements and causal relations, in order to identify macrostructure features which distinguish bilingual children with SLI from those with typical development...
August 24, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28886424/emotional-and-behavioural-needs-in-children-with-specific-language-impairment-and-in-children-with-autism-spectrum-disorder-the-importance-of-pragmatic-language-impairment
#8
Wenche Andersen Helland, Turid Helland
BACKGROUND: Language problems may negatively affect children's behaviour and have detrimental effects on the development of peer-relations. AIMS: We investigated and compared emotional and behavioural profiles in children with SLI and in children with ASD aged 6-15 years and explored to what extent pragmatic language problems contributed to the emotional and behavioural needs (EBN) in these clinical groups. METHODS AND PROCEDURES: The ASD group consisted of 23 children (19 boys; 4 girls) and the SLI group consisted of 20 children (18 boys; 2 girls)...
September 4, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28863035/same-or-different-the-overlap-between-children-with-auditory-processing-disorders-and-children-with-other-developmental-disorders-a-systematic-review
#9
Ellen de Wit, Pim van Dijk, Sandra Hanekamp, Margot I Visser-Bochane, Bert Steenbergen, Cees P van der Schans, Margreet R Luinge
OBJECTIVES: Children diagnosed with auditory processing disorders (APD) experience difficulties in auditory functioning and with memory, attention, language, and reading tasks. However, it is not clear whether the behavioral characteristics of these children are distinctive from the behavioral characteristics of children diagnosed with a different developmental disorder, such as specific language impairment (SLI), dyslexia, attention-deficit hyperactivity disorder (ADHD), learning disorder (LD), or autism spectrum disorder...
August 31, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28854315/distributed-training-enhances-implicit-sequence-acquisition-in-children-with-specific-language-impairment
#10
Lise Desmottes, Thierry Meulemans, Marie-Aude Patinec, Christelle Maillart
Purpose: This study explored the effects of 2 different training structures on the implicit acquisition of a sequence in a serial reaction time (SRT) task in children with and without specific language impairment (SLI). Method: All of the children underwent 3 training sessions, followed by a retention session 2 weeks after the last session. In the massed-training condition, the 3 training sessions were in immediate succession on 1 day, whereas in the distributed-training condition, the 3 training sessions were spread over a 1-week period in an expanding schedule format...
September 18, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28832884/-whatdunit-sentence-comprehension-abilities-of-children-with-sli-sensitivity-to-word-order-in-canonical-and-noncanonical-structures
#11
James W Montgomery, Ronald B Gillam, Julia L Evans, Alexander V Sergeev
Purpose: With Aim 1, we compared the comprehension of and sensitivity to canonical and noncanonical word order structures in school-age children with specific language impairment (SLI) and same-age typically developing (TD) children. Aim 2 centered on the developmental improvement of sentence comprehension in the groups. With Aim 3, we compared the comprehension error patterns of the groups. Method: Using a "Whatdunit" agent selection task, 117 children with SLI and 117 TD children (ages 7:0-11:11, years:months) propensity matched on age, gender, mother's education, and family income pointed to the picture that best represented the agent in semantically implausible canonical structures (subject-verb-object, subject relative) and noncanonical structures (passive, object relative)...
August 22, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28820919/a-preliminary-comparison-of-reading-subtypes-in-a-clinical-sample-of-children-with-specific-language-impairment
#12
Krystal L Werfel, Hannah Krimm
Purpose: The purpose of this preliminary study was to (a) compare the pattern of reading subtypes among a clinical sample of children with specific language impairment (SLI) and children with typical language and (b) evaluate phonological and nonphonological language deficits within each reading impairment subtype. Method: Participants were 32 children with SLI and 39 children with typical language in Grades 2 through 4. Each child was classified as demonstrating 1 of 4 reading subtypes on the basis of word-level and text-level skills: typical reading, dyslexia, specific reading comprehension impairment, or garden variety reading impairment...
September 18, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28795220/achieving-and-maintaining-lung-volume-in-the-preterm-infant-from-the-first-breath-to-the-nicu
#13
REVIEW
Gianluca Lista, Andrés Maturana, Fernando R Moya
The main goal for the neonatologist is to facilitate the adaptation to extra-uterine life during initial transition, while minimizing lung injury opening and protecting the premature lung from the first breath onwards. An appropriate management from birth should lead to the achievement of an early functional residual capacity (FRC), and the following steps should aim at maintaining an adequate lung volume. To date, different strategies are available to optimize fetal-neonatal transition and promote lung recruitment...
August 10, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28764774/-sly-grog-and-homebrew-a-qualitative-examination-of-illicit-alcohol-and-some-of-its-impacts-on-indigenous-communities-with-alcohol-restrictions-in-regional-and-remote-queensland-australia
#14
Michelle S Fitts, Jan Robertson, Simon Towle, Chris M Doran, Robyn McDermott, Adrian Miller, Stephen Margolis, Valmae Ypinazar, Alan R Clough
BACKGROUND: Indigenous communities in Queensland (Australia) have been subject to Alcohol Management Plans since 2002/03, with significant penalties for breaching restrictions. 'Sly grog' and 'homebrew' provide access to alcohol despite restrictions. This paper describes how this alcohol is made available and the risks and impacts involved. In affected towns and communities across a large area of rural and remote Queensland, interviews and focus groups documented experiences and views of 255 long-standing community members and service providers...
August 1, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28754563/changes-in-gene-expression-variability-reveal-a-stable-synthetic-lethal-interaction-network-in-brca2-ovarian-cancers
#15
Raymund Bueno, Jessica C Mar
Synthetic lethal interactions (SLIs) are robust mechanisms that provide cells with the ability to remain viable despite having mutations in genes critical to the DNA damage response, a core cellular process. Studies in model organisms such as S. cerevisiae showed that thousands of genes important in maintaining DNA integrity cooperated in a SLI network. Two genes participate in a SLI when a mutation in one gene has no effect on the cell, but mutations in both interacting genes are lethal. Furthermore in C. elegans, a mutation in a critical gene that is important for development induced a change in expression variability in the synthetic lethal interactor...
July 25, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28735298/foxp1-related-intellectual-disability-syndrome-a-recognisable-entity
#16
Ilse Meerschaut, Daniel Rochefort, Nicole Revençu, Justine Pètre, Christina Corsello, Guy A Rouleau, Fadi F Hamdan, Jacques L Michaud, Jenny Morton, Jessica Radley, Nicola Ragge, Sixto García-Miñaúr, Pablo Lapunzina, Maria Palomares Bralo, Maria Ángeles Mori, Stéphanie Moortgat, Valérie Benoit, Sandrine Mary, Nele Bockaert, Ann Oostra, Olivier Vanakker, Milen Velinov, Thomy Jl de Ravel, Djalila Mekahli, Jonathan Sebat, Keith K Vaux, Nataliya DiDonato, Andrea K Hanson-Kahn, Louanne Hudgins, Bruno Dallapiccola, Antonio Novelli, Luigi Tarani, Joris Andrieux, Michael J Parker, Katherine Neas, Berten Ceulemans, An-Sofie Schoonjans, Darina Prchalova, Marketa Havlovicova, Miroslava Hancarova, Magdalena Budisteanu, Annelies Dheedene, Björn Menten, Patrick A Dion, Damien Lederer, Bert Callewaert
BACKGROUND: Mutations in forkhead box protein P1 (FOXP1) cause intellectual disability (ID) and specific language impairment (SLI), with or without autistic features (MIM: 613670). Despite multiple case reports no specific phenotype emerged so far. METHODS: We correlate clinical and molecular data of 25 novel and 23 previously reported patients with FOXP1 defects. We evaluated FOXP1 activity by an in vitro luciferase model and assessed protein stability in vitro by western blotting...
July 22, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28727489/third-person-singular-s-in-typical-development-and-specific-language-impairment-input-and-neighbourhood-density
#17
Justin B Kueser, Laurence B Leonard, Patricia Deevy
The purpose of this study was to examine factors promoting the use of third person singular -s by 23 children with specific language impairment (SLI) and 21 children with typical development (TD). Relative proportions of third person singular -s forms in the input (input proportion) were calculated for 25 verbs based on data from an American English corpus of child-directed speech. Neighbourhood density values were also collected for these verbs. With previously collected probes of third person singular -s use for each of these verbs, we found with logistic regression that input proportion was positively associated with the likelihood of third person singular -s use for both groups...
July 20, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28724132/applying-an-integrative-framework-of-executive-function-to-preschoolers-with-specific-language-impairment
#18
Leah L Kapa, Elena Plante, Kevin Doubleday
Purpose: The first goal of this research was to compare verbal and nonverbal executive function abilities between preschoolers with and without specific language impairment (SLI). The second goal was to assess the group differences on 4 executive function components in order to determine if the components may be hierarchically related as suggested within a developmental integrative framework of executive function. Method: This study included 26 4- and 5-year-olds diagnosed with SLI and 26 typically developing age- and sex-matched peers...
August 16, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28716287/kidney-dysfunction-and-silent-brain-infarction-in-generally-healthy-adults
#19
Sang Hyuck Kim, Dong Wook Shin, Jae Moon Yun, Ji Eun Lee, Jae-Sung Lim, Be Long Cho, Hyung-Min Kwon, Jin-Ho Park
BACKGROUND: The association between silent brain infarction (SBI) and estimated glomerular filtration rate (eGFR)-based kidney dysfunction has not yet been definitively confirmed. This study aimed to investigate the association in generally healthy adults without a previous history of stroke or overt kidney disease. METHODS: The data from the screening health check-up program in the Seoul National University Hospital Health Promotion Center from January 1, 2009 to December 31, 2013 were used...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28715546/sensitivity-to-audiovisual-temporal-asynchrony-in-children-with-a-history-of-specific-language-impairment-and-their-peers-with-typical-development-a-replication-and-follow-up-study
#20
Natalya Kaganovich
Purpose: Earlier, my colleagues and I showed that children with a history of specific language impairment (H-SLI) are significantly less able to detect audiovisual asynchrony compared with children with typical development (TD; Kaganovich & Schumaker, 2014). Here, I first replicate this finding in a new group of children with H-SLI and TD and then examine a relationship among audiovisual function, attention skills, and language in a combined pool of children. Method: The stimuli were a pure tone and an explosion-shaped figure...
August 16, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
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