Melissa Klug, Verena Enneking, Tiana Borgers, Charlotte M Jacobs, Katharina Dohm, Anna Kraus, Dominik Grotegerd, Nils Opel, Jonathan Repple, Thomas Suslow, Susanne Meinert, Hannah Lemke, Elisabeth J Leehr, Jochen Bauer, Udo Dannlowski, Ronny Redlich
Biased emotion processing has been suggested to underlie the etiology and maintenance of depression. Neuroimaging studies have shown mood-congruent alterations in amygdala activity in patients with acute depression, even during early, automatic stages of emotion processing. However, due to a lack of prospective studies over periods longer than 8 weeks, it is unclear whether these neurofunctional abnormalities represent a persistent correlate of depression even in remission. In this prospective case-control study, we aimed to examine brain functional correlates of automatic emotion processing in the long-term course of depression...
January 26, 2024: Molecular Psychiatry