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https://www.readbyqxmd.com/read/27920626/evaluation-of-serum-vitamin-d-levels-in-adolescents-with-pubertal-gynecomastia
#1
Melis Pehlivantürk Kızılkan, Sinem Akgül, Filiz Akbıyık, Orhan Derman, Nuray Kanbur
BACKGROUND: Since vitamin D has an inhibitory function on ductal morphogenesis of the pubertal mammary gland, it may have a role in the development of gynecomastia. The aim of this study was to determine the effect of vitamin D deficiency on the development of pubertal gynecomastia. METHODS: Serum 25-hydroxyvitamin D (25D) levels in 50 adolescents with pubertal gynecomastia and 54 healthy controls between the ages of 11 and 17 years were compared. RESULTS: Mean 25D level was 14...
October 2016: Breast Care
https://www.readbyqxmd.com/read/27905877/mineralocorticoid-receptor-antagonists-for-heart-failure-systematic-review-and-meta-analysis
#2
Nicolas M Berbenetz, Marko Mrkobrada
BACKGROUND: Mineralocorticoid receptor antagonists (MRAs) have been associated with improved patient outcomes in patients with heart failure with reduced ejection fraction (HFrEF) but not preserved ejection fraction (HFpEF). We conducted a systematic review and meta-analysis of selective and nonselective MRAs in HFrEF and HFpEF. METHODS: We searched Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE. We included randomized controlled trials (RCT) of MRAs in adults with HFpEF or HFrEF if they reported data on major adverse cardiac events or drug safety...
December 1, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27879556/who-gets-severe-gynecomastia-among-hiv-infected-children-in-the-uk-and-ireland
#3
Julia Kenny, Katja Doerholt, Di M Gibb, Ali Judd
There are few data on gynecomastia in HIV-infected children. Within the UK/Ireland's national cohort, 56/1,873 (3%) HIV-infected children had gynecomastia, of which 10 (0.5%) were severe. All 10 had received antiretroviral therapy for a median of 27.5 [21,42] months; 4/10 had received efavirenz, 7/10 and 6/10 stavudine and/or didanosine respectively. Five were non-reversible, despite changing ART, and required breast reduction surgery.
November 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27873740/response-to-the-anastrozole-treatment-in-a-case-with-peutz-jeghers-syndrome-who-was-detected-to-have-large-cell-calcifying-sertoli-cell-tumor-and-developed-pre-pubertal-gynecomastia
#4
Merve Koç Yekedüz, Zeynep Şıklar, Berk Burgu, Zarife Kuloğlu, Pınar Kocaay, Emine Çamtosun, Mehmet İsakoca, Aydan Kansu, Tarkan Soygür, Merih Berberoğlu
Peutz-Jeghers Syndrome (PJS) is inherited as an autosomal dominant trait which is characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of neoplasm. Large Cell Calcifying Sertoli Cell Tumor (LCCSCT) is a kind of sex cord-stromal tumor, often bilateral and multifocal, accounting for 0.4 -1.5% of entire testicular tumors which may co-exist with PJS and is characterized radiologically by calcification foci within the testes. Surgical treatment options for this tumor range from testis-preserving surgery to radical orchiectomy...
November 22, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27853693/the-satisfaction-rate-among-patients-and-surgeons-after-periareolar-surgical-approach-to-gynecomastia-along-with-liposuction
#5
Ahmad Reza Taheri, Mohamad Reza Farahvash, Hamid Reza Fathi, Koorosh Ghanbarzadeh, Bijan Faridniya
BACKGROUND: Surgery, as the main approach in higher stages of gynecomastia, has different techniques regarding the staging of the disease. The more the grade of gynecomastia, the more complicated the used surgical techniques, conventionally. This study assessed the success rate of the simplest surgical technique in higher grades of gynecology as well as the satisfaction rate in patients and surgeon to offer using the technique for higher grades of the disease. METHODS: To evaluate the success and the satisfaction rates of periareolar incision and liposuction among patients with grade II and III gynecomastia, this cross-sectional study was conducted...
September 2016: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/27853073/feminizing-adrenocortical-carcinoma-with-distinct-histopathological-findings
#6
Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama
We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27829454/prolactin-related-symptoms-during-risperidone-maintenance-treatment-results-from-a-prospective-multicenter-study-of-schizophrenia
#7
Qijing Bo, Fang Dong, Xianbin Li, Zhimin Wang, Xin Ma, Chuanyue Wang
BACKGROUND: This study aimed to investigate prolactin related symptoms (PRS) in individuals with schizophrenia during risperidone maintenance treatment for one year, as well as to identify the risk factors for PRS. METHODS: In a multicenter, randomized, controlled, longitudinal study, clinically stabilized schizophrenia patients (N = 374) were randomized to a no-dose-reduction group (N = 129) and 4-week (N = 125) and 26-week (N = 120) reduction groups, in which the original dose was followed by a 50 % reduction over 8 weeks and subsequently maintained...
November 9, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27806792/-analysis-of-clinical-features-and-related-genes-variation-in-five-patients-with-46-xx-male-syndrome
#8
X Y Qin, W K Dong, W Wang, Z Y Dong, Y Xiao, W L Lu, D F Wang
Objective: To explore the clinical manifestations and molecular features of 46, XX male syndrome. Method: The clinical and molecular data of five 46, XX male syndrome cases treated in the Department of Pediatrics of Shanghai Ruijin Hospital form August 2010 to August 2014 were retrospectively analyzed. Result: The five patients were all sociopsychologically males and came to hospital respectively for short stature, ambiguous genitalia or gynecomastia. They were all below the normal male's average height, and their karyotype was all 46, XX...
November 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27805927/management-of-gynecomastia-in-patients-with-different-body-types-considerations-on-312-consecutive-treated-cases
#9
Alessandro Innocenti, Dario Melita, Francesco Mori, Francesco Ciancio, Marco Innocenti
BACKGROUND: Gynecomastia is a common finding in male subjects which incidence varies widely in the world population. In adolescents, it is frequently temporary but, if it becomes persistent, it generates considerable embarrassment, inducing the patients to seek surgical consultation. Even in patients with good body contour, gynecomastia creates even greater distress considering the special attention given by these subjects to their physical appearance. The authors present their experience in the treatment of gynecomastia comparing different body types of patients with the aim to investigate dissimilar expectations, needs and surgical outcomes thus optimizing the management of the pathological condition, achieving high levels of agreement and reducing unsatisfied patients arising from cosmetic surgery...
November 1, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27784526/abdominal-elephantiasis-nostras-verrucosa-an-underrecognized-disorder
#10
Derek Ho, Eve J Lowenstein
Case 1 A 60-year-old African American man presented with a medical history of morbid obesity (weighing more than 550 lb), benign prostatic hyperplasia, hyperlipidemia, gynecomastia, atrial fibrillation, hypertension, chronic obstructive pulmonary disease, psoriasis, sleep apnea, and cardiomegaly. His size has limited his ability to clean himself properly. He experiences chronic and recurrent skin irritation and cellulitis possibly secondary to intertriginous superinfection, lymphedema, and venous stasis. On examination, his abdomen showed heavy skinfolding with hyperpigmentation, cobblestone and velvety changes, thickening and fibrotic induration of the skin, focal areas of redness, and tenderness on palpation (Figure 1A and 1B)...
2016: Skinmed
https://www.readbyqxmd.com/read/27753182/quality-of-life-outcomes-from-the-prostate-adenocarcinoma-transcutaneous-hormones-patch-trial-evaluating-luteinising-hormone-releasing-hormone-agonists-versus-transdermal-oestradiol-for-androgen-suppression-in-advanced-prostate-cancer
#11
Duncan C Gilbert, Trinh Duong, Howard G Kynaston, Abdulla A Alhasso, Fay H Cafferty, Stuart D Rosen, Subramanian Kanaga-Sundaram, Sanjay Dixit, Marc Laniado, Sanjeev Madaan, Gerald Collins, Alvan Pope, Andrew Welland, Matthew Nankivell, Richard Wassersug, Mahesh K B Parmar, Ruth E Langley, Paul D Abel
OBJECTIVES: To compare quality-of-life (QoL) outcomes at 6 months between men with advanced prostate cancer receiving either transdermal oestradiol (tE2) or luteinising hormone-releasing hormone agonists (LHRHa) for androgen-deprivation therapy (ADT). PATIENTS AND METHODS: Men with locally advanced or metastatic prostate cancer participating in an ongoing randomised, multicentre UK trial comparing tE2 versus LHRHa for ADT were enrolled into a QoL sub-study. tE2 was delivered via three or four transcutaneous patches containing oestradiol 100 μg/24 h...
October 18, 2016: BJU International
https://www.readbyqxmd.com/read/27734795/breast-us-as-primary-imaging-modality-for-diagnosing-gynecomastia
#12
M Telegrafo, T Introna, L Coi, I Cornacchia, L Rella, A A Stabile Ianora, G Angelelli, M Moschetta
AIM: To assess the role of breast US in diagnosing and classifying gynecomastia as the primary imaging modality and to compare US findings and classification system with the mammographic ones. PATIENTS AND METHODS: 48 patients suspected of having gynecomastia underwent mammography and US. Two radiologists in consensus retrospectively evaluated mammograms and sonograms. Both US and mammographic images were evaluated categorizing gynecomastia into non-mass, nodular and flame shaped patterns...
May 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/27721718/ductal-carcinoma-in-situ-of-the-male-breast
#13
Melissa Brents, John Hancock
BACKGROUND: Ductal carcinoma in situ of the male breast is an unusual lesion and most often associated with invasive carcinoma. On rare occasions when the in situ component is present in pure form, histological grade is almost always low to intermediate. Imaging for these patients is difficult as gynecomastia is often present and can mask underlying calcifications or carcinoma. CASE REPORT: We report a case of pure high-grade ductal carcinoma in situ of the male breast in a patient with clear nipple discharge...
August 2016: Breast Care
https://www.readbyqxmd.com/read/27679453/surgical-management-of-gynecomastia-subcutaneous-mastectomy-and-liposuction
#14
Dae Hwa Kim, Il Hwan Byun, Won Jai Lee, Dong Kyun Rah, Ji Ye Kim, Dong Won Lee
BACKGROUND: The treatment of gynecomastia depends on multiple factors, and the best modality is controversial. In this study, we aimed to determine the best management approach by comparing outcomes of two groups of patients with gynecomastia who received subcutaneous mastectomy combined with liposuction and liposuction only. METHODS: We conducted a retrospective analysis of 64 patients who underwent surgery for gynecomastia. We divided the patients into two groups: group A, patients who underwent liposuction only; and group B, patients who underwent liposuction and subcutaneous mastectomy...
December 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27629979/gynecomastia-as-a-paraneoplastic-symptom-of-choriocarcinoma
#15
Hiromichi Yamane, Nobuaki Ochi, Yoshihiro Honda, Nagio Takigawa
No abstract text is available yet for this article.
2016: Internal Medicine
https://www.readbyqxmd.com/read/27622122/anatomy-of-the-gynecomastia-tissue-and-its-clinical-significance
#16
Mordecai Blau, Ron Hazani, Daniel Hekmat
BACKGROUND: Gynecomastia is a very common entity in men, and several authors estimate that approximately 50% to 70% of the male population has palpable breast tissue. Much has been published with regard to the etiology, diagnosis, and treatment of gynecomastia. However, the anatomy of the gynecomastia tissue remains elusive to most surgeons. PURPOSE: The purpose of this article was to define the shape and consistency of the glandular tissue based on the vast experience of the senior author (MB)...
August 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27617217/inherited-xq13-2-q21-31-duplication-in-a-boy-with-recurrent-seizures-and-pubertal-gynecomastia-clinical-chromosomal-and-acgh-characterization
#17
Natália D Linhares, Eugênia R Valadares, Silvia S da Costa, Rodrigo R Arantes, Luiz Roberto de Oliveira, Carla Rosenberg, Angela M Vianna-Morgante, Marta Svartman
We report on a 16-year-old boy with a maternally inherited ~ 18.3 Mb Xq13.2-q21.31 duplication delimited by aCGH. As previously described in patients with similar duplications, his clinical features included intellectual disability, developmental delay, speech delay, generalized hypotonia, infantile feeding difficulties, self-injurious behavior, short stature and endocrine problems. As additional findings, he presented recurrent seizures and pubertal gynecomastia. His mother was phenotypically normal and had completely skewed inactivation of the duplicated X chromosome, as most female carriers of such duplications...
September 2016: Meta Gene
https://www.readbyqxmd.com/read/27612041/incidental-unilateral-and-bilateral-ductal-carcinoma-in-situ-encountered-in-the-surgical-management-of-young-male-gynecomastia
#18
Bader Hamza Shirah, Hamza Assad Shirah
BACKGROUND: The increased risk for malignant tumors associated with male gynecomastia has been well established and many authors have reported cases of concurrent gynecomastia and ductal carcinoma in situ (DCIS) in the same breast. Synchronous bilateral breast cancer in association with gynecomastia is exceptionally rare. We aim to report and evaluate the management outcome of 5 cases of gynecomastia associated with DCIS (1 bilateral and 4 unilateral). METHODS: A retrospective database analysis of the surgical treatment outcome of 74 male patients who had gynecomastia was done...
July 28, 2016: Breast Disease
https://www.readbyqxmd.com/read/27510681/sertoli-cell-tumor-arising-in-a-cryptorchid-testis-presenting-as-a-content-of-inguinal-hernial-sac
#19
Kusuma Venkatesh, Mahantappa Hemalata, S Sathyavathi, Satish Kumar
Sertoli cell tumors (SCTs) are rare tumors accounting for <1% of all testicular tumors. Here, we report a rare case of SCT in a 60-year-old man presenting as a painless swelling in the right groin since childhood. Clinically, he presented with right-sided inguinal hernia with absence of the right testis. He had normal left testis and had no gynecomastia or infertility. The specimen of hernial sac showed testis with a 1.6 cm × 1.5 cm nodular mass having gray tan-cut surface. Histopathologically, the testis showed atrophy and the nodular portion showed tumor cells arranged in tubular and microcystic pattern, with no solid pattern or necrosis...
July 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27502882/association-between-plasma-kisspeptin-levels-and-adolescent-gynecomastia
#20
Mustafa Arif Aluclu, Selcuk Sen, Muazez Cevik
BACKGROUND: Gynecomastia is defined as benign proliferation of male breast glandular tissue. To date, the pathophysiology of adolescent gynecomastia (AG) remains unclear. Kisspeptin is a polypeptide that plays an important role in the regulation of the hypothalamic-pituitary-gonadal hormonal axis. In this study, we investigated whether there is a relationship between kisspeptin and AG. MATERIALS AND METHODS: This study included 40 males between 9 and 18 years of age diagnosed with gynecomastia...
July 2016: African Journal of Paediatric Surgery: AJPS
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